YU63003A - Acilirani indanilamini i njihova upotreba kao farmaceutika - Google Patents

Acilirani indanilamini i njihova upotreba kao farmaceutika

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Publication number
YU63003A
YU63003A YU63003A YUP63003A YU63003A YU 63003 A YU63003 A YU 63003A YU 63003 A YU63003 A YU 63003A YU P63003 A YUP63003 A YU P63003A YU 63003 A YU63003 A YU 63003A
Authority
YU
Yugoslavia
Prior art keywords
hypertension
alkyl
useful
diabetes
description
Prior art date
Application number
YU63003A
Other languages
English (en)
Inventor
Hartmut Strobel
Paulus Wohlfart
Alena Safarova
Armin Walser
Teri Suzuki
Ramalinga M. Dharanipragada
Karl Schoenafinger
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU63003A publication Critical patent/YU63003A/sh

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

Ovaj pronalazak se odnosi na acilirane indanilamine na osnovu opste formule (I) gde R1-R4 imaju znacenja data u opisu, A je CH2, CHOH ili CH-(C1-C3-alkil), B je CH2 ili CH-(C1-C3-alkil) i R5 je aril ili heteroaril grupa, moguce supstituisana sa supstituentima navedenim u opisu. Ova jedinjenja su korisna u ushodnoj regulaciji endotelijalne azotoksid sintaze (eNOS) i prema tome su korisna u prizvodnji lekova za lecenje kardiovaskularnih bolesti, stabilne ili nestabilne angine pectoris, koronarne bolesti srca, Prinzmetal angine, akutnog koronarnog sindroma, otkazivanja srca, infarkta miokarda, sloga, tromboze, bolesti zacepljenja perifernih arterija, endotelijalne disfunkcije ateroskleroze, restenoze, ostecenja endotelijuma posle PTCA, hipertenzije, esencijalne hipertenzije, plucne hipertenzije, sekundarne hipertenzije, renovaskularne hipertenzije, hronicnog glomerulonefritisa, disfunkcije erekcije, ventrikularnih aritmija, dijabetesa ili komplikacija dijabetesa, nefropatije ili retinopatije, angiogeneze, bronhijalne astme, hronicnog otkazivanja bubrega, ciroze jetre, osteoporoze, ogranicene mogucnosti pamcenja, ogranicenog kapaciteta za ucenje, ili za snizavanje kardiovaskularnog rizika kod zena u postmenopauzi ili posle uzimanja kontraceptiva.
YU63003A 2001-02-13 2002-02-12 Acilirani indanilamini i njihova upotreba kao farmaceutika YU63003A (sh)

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