HUE064609T2 - Tetrahidronaftalin és tetrahidroizokinolin származékok mint ösztrogénreceptor-lebontó anyagok - Google Patents

Tetrahidronaftalin és tetrahidroizokinolin származékok mint ösztrogénreceptor-lebontó anyagok

Info

Publication number
HUE064609T2
HUE064609T2 HUE20150584A HUE20150584A HUE064609T2 HU E064609 T2 HUE064609 T2 HU E064609T2 HU E20150584 A HUE20150584 A HU E20150584A HU E20150584 A HUE20150584 A HU E20150584A HU E064609 T2 HUE064609 T2 HU E064609T2
Authority
HU
Hungary
Prior art keywords
tetrahydronaphthalene
receptor antagonists
estrogen receptor
tetrahydroisoquinoline derivatives
tetrahydroisoquinoline
Prior art date
Application number
HUE20150584A
Other languages
English (en)
Hungarian (hu)
Inventor
Andrew P Crew
Yimin Qian
Hanqing Dong
Jing Wang
Keith R Hornberger
Original Assignee
Arvinas Operations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arvinas Operations Inc filed Critical Arvinas Operations Inc
Publication of HUE064609T2 publication Critical patent/HUE064609T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Other In-Based Heterocyclic Compounds (AREA)
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HUE20150584A 2016-12-01 2017-12-01 Tetrahidronaftalin és tetrahidroizokinolin származékok mint ösztrogénreceptor-lebontó anyagok HUE064609T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662429041P 2016-12-01 2016-12-01
US201762540049P 2017-08-01 2017-08-01

Publications (1)

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HUE064609T2 true HUE064609T2 (hu) 2024-04-28

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US (7) US10647698B2 (enExample)
EP (2) EP3689868B1 (enExample)
JP (7) JP6957620B2 (enExample)
KR (3) KR20240063185A (enExample)
CN (4) CN110291087B (enExample)
AU (5) AU2017366693B2 (enExample)
BR (1) BR112019011200B1 (enExample)
CA (1) CA3042968C (enExample)
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ES (1) ES2967404T3 (enExample)
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KR20200020988A (ko) 2020-02-26
KR102674902B1 (ko) 2024-06-14
IL272527B (en) 2021-07-29
US20220274955A1 (en) 2022-09-01
AU2024201437A1 (en) 2024-03-21
US20250320195A1 (en) 2025-10-16
US20180155322A1 (en) 2018-06-07
PT3689868T (pt) 2024-01-02
US20240076281A1 (en) 2024-03-07
IL297717A (en) 2022-12-01
LT3689868T (lt) 2023-12-27
JP2021169479A (ja) 2021-10-28
IL284424B2 (en) 2023-04-01
RU2019120120A (ru) 2020-12-28

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