HUE031051T2 - Synthetic glycopyranosyl lipid adjuvant and vaccine compositions containing it - Google Patents

Info

Publication number

HUE031051T2

HUE031051T2 HUE10784178A HUE10784178A HUE031051T2 HU E031051 T2 HUE031051 T2 HU E031051T2 HU E10784178 A HUE10784178 A HU E10784178A HU E10784178 A HUE10784178 A HU E10784178A HU E031051 T2 HUE031051 T2 HU E031051T2

Authority

HU

Hungary

Prior art keywords

gla

mmol

antigen

compound

vaccine

Prior art date

2009-06-05

Links

• Espacenet
• Global Dossier
• Discuss

• 229960005486 vaccine Drugs 0.000 title claims description 89
• 239000000203 mixture Substances 0.000 title description 196
• 239000002671 adjuvant Substances 0.000 title description 63
• -1 glucopyranosyl lipid Chemical class 0.000 title description 54
• 108090000623 proteins and genes Proteins 0.000 claims description 34
• 239000013598 vector Substances 0.000 claims description 18
• 241000700605 Viruses Species 0.000 claims description 17
• 239000000126 substance Substances 0.000 claims description 9
• 239000000463 material Substances 0.000 claims description 7
• 241000701161 unidentified adenovirus Species 0.000 claims description 6
• 230000007480 spreading Effects 0.000 claims description 3
• 238000003892 spreading Methods 0.000 claims description 3
• 239000004927 clay Substances 0.000 claims 2
• 241000237858 Gastropoda Species 0.000 claims 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
• 210000001367 artery Anatomy 0.000 claims 1
• 235000013399 edible fruits Nutrition 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 239000011593 sulfur Substances 0.000 claims 1
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 159
• 239000000427 antigen Substances 0.000 description 151
• 108091007433 antigens Proteins 0.000 description 150
• 102000036639 antigens Human genes 0.000 description 150
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 114
• YGPZYYDTPXVBRA-RTDBHSBRSA-N [(2r,3s,4r,5r,6s)-2-[[(2r,3r,4r,5s,6r)-3-[[(3r)-3-dodecanoyloxytetradecanoyl]amino]-6-(hydroxymethyl)-5-phosphonooxy-4-[(3r)-3-tetradecanoyloxytetradecanoyl]oxyoxan-2-yl]oxymethyl]-3,6-dihydroxy-5-[[(3r)-3-hydroxytetradecanoyl]amino]oxan-4-yl] (3r)-3-hydr Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](O)O1 YGPZYYDTPXVBRA-RTDBHSBRSA-N 0.000 description 104
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 94
• 150000001875 compounds Chemical class 0.000 description 68
• 238000000034 method Methods 0.000 description 65
• 230000028993 immune response Effects 0.000 description 52
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 51
• 239000003921 oil Substances 0.000 description 45
• 235000019198 oils Nutrition 0.000 description 44
• 239000000243 solution Substances 0.000 description 44
• 210000004027 cell Anatomy 0.000 description 43
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 42
• 238000005160 1H NMR spectroscopy Methods 0.000 description 38
• 239000000839 emulsion Substances 0.000 description 35
• 208000015181 infectious disease Diseases 0.000 description 33
• 239000000047 product Substances 0.000 description 33
• 206010028980 Neoplasm Diseases 0.000 description 32
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
• 125000000217 alkyl group Chemical group 0.000 description 31
• 102000004169 proteins and genes Human genes 0.000 description 31
• 235000018102 proteins Nutrition 0.000 description 30
• 108090000765 processed proteins & peptides Proteins 0.000 description 27
• 239000007787 solid Substances 0.000 description 27
• 102000002689 Toll-like receptor Human genes 0.000 description 25
• 108020000411 Toll-like receptor Proteins 0.000 description 25
• 239000008194 pharmaceutical composition Substances 0.000 description 25
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 24
• 238000010898 silica gel chromatography Methods 0.000 description 22
• 201000011510 cancer Diseases 0.000 description 21
• 230000004044 response Effects 0.000 description 21
• 201000008827 tuberculosis Diseases 0.000 description 21
• 208000023275 Autoimmune disease Diseases 0.000 description 20
• 241000282414 Homo sapiens Species 0.000 description 20
• 230000003308 immunostimulating effect Effects 0.000 description 20
• 201000004792 malaria Diseases 0.000 description 20
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
• 230000000694 effects Effects 0.000 description 19
• 239000000706 filtrate Substances 0.000 description 19
• 102000004196 processed proteins & peptides Human genes 0.000 description 19
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 18
• 239000000556 agonist Substances 0.000 description 18
• 239000011541 reaction mixture Substances 0.000 description 18
• 102000004127 Cytokines Human genes 0.000 description 17
• 108090000695 Cytokines Proteins 0.000 description 17
• 241000701806 Human papillomavirus Species 0.000 description 17
• 239000002253 acid Substances 0.000 description 17
• 201000010099 disease Diseases 0.000 description 17
• 238000009472 formulation Methods 0.000 description 17
• 210000000987 immune system Anatomy 0.000 description 17
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
• 238000006243 chemical reaction Methods 0.000 description 16
• 238000001914 filtration Methods 0.000 description 16
• 239000007788 liquid Substances 0.000 description 16
• 229920001184 polypeptide Polymers 0.000 description 16
• 238000002360 preparation method Methods 0.000 description 16
• 210000001744 T-lymphocyte Anatomy 0.000 description 15
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
• 230000014509 gene expression Effects 0.000 description 15
• 229930182490 saponin Natural products 0.000 description 15
• 235000017709 saponins Nutrition 0.000 description 15
• 150000007949 saponins Chemical class 0.000 description 15
• 229920006395 saturated elastomer Polymers 0.000 description 15
• 108010074328 Interferon-gamma Proteins 0.000 description 14
• 238000004587 chromatography analysis Methods 0.000 description 14
• 230000003053 immunization Effects 0.000 description 14
• 238000002649 immunization Methods 0.000 description 14
• 239000003607 modifier Substances 0.000 description 14
• 244000052769 pathogen Species 0.000 description 14
• 150000003839 salts Chemical class 0.000 description 14
• 239000002904 solvent Substances 0.000 description 14
• 210000001519 tissue Anatomy 0.000 description 14
• 241001465754 Metazoa Species 0.000 description 13
• 108091034117 Oligonucleotide Proteins 0.000 description 13
• 239000012267 brine Substances 0.000 description 13
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 13
• 239000000568 immunological adjuvant Substances 0.000 description 13
• 230000006698 induction Effects 0.000 description 13
• 239000000546 pharmaceutical excipient Substances 0.000 description 13
• 238000003259 recombinant expression Methods 0.000 description 13
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 13
• 241000725303 Human immunodeficiency virus Species 0.000 description 12
• 238000003556 assay Methods 0.000 description 12
• CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 description 12
• 238000004519 manufacturing process Methods 0.000 description 12
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 12
• 230000015572 biosynthetic process Effects 0.000 description 11
• 239000003153 chemical reaction reagent Substances 0.000 description 11
• 150000007523 nucleic acids Chemical group 0.000 description 11
• 238000011282 treatment Methods 0.000 description 11
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 10
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 10
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 10
• 239000002158 endotoxin Substances 0.000 description 10
• 125000000524 functional group Chemical group 0.000 description 10
• 108020001507 fusion proteins Proteins 0.000 description 10
• 102000037865 fusion proteins Human genes 0.000 description 10
• 150000002632 lipids Chemical class 0.000 description 10
• 230000001717 pathogenic effect Effects 0.000 description 10
• 239000000741 silica gel Substances 0.000 description 10
• 229910002027 silica gel Inorganic materials 0.000 description 10
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 10
• 239000000725 suspension Substances 0.000 description 10
• 238000003786 synthesis reaction Methods 0.000 description 10
• 241000699670 Mus sp. Species 0.000 description 9
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 9
• 230000000890 antigenic effect Effects 0.000 description 9
• 238000001514 detection method Methods 0.000 description 9
• 238000000338 in vitro Methods 0.000 description 9
• 238000001727 in vivo Methods 0.000 description 9
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 9
• 244000045947 parasite Species 0.000 description 9
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 9
• 229940031439 squalene Drugs 0.000 description 9
• 208000030507 AIDS Diseases 0.000 description 8
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
• 229940046168 CpG oligodeoxynucleotide Drugs 0.000 description 8
• 102100037850 Interferon gamma Human genes 0.000 description 8
• 108700006640 OspA Proteins 0.000 description 8
• 241000223960 Plasmodium falciparum Species 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• 150000001412 amines Chemical class 0.000 description 8
• 239000002585 base Substances 0.000 description 8
• 239000003795 chemical substances by application Substances 0.000 description 8
• 239000003937 drug carrier Substances 0.000 description 8
• 230000001965 increasing effect Effects 0.000 description 8
• 230000002458 infectious effect Effects 0.000 description 8
• 229920006008 lipopolysaccharide Polymers 0.000 description 8
• 108020004707 nucleic acids Proteins 0.000 description 8
• 102000039446 nucleic acids Human genes 0.000 description 8
• 239000012074 organic phase Substances 0.000 description 8
• 239000012071 phase Substances 0.000 description 8
• 125000006239 protecting group Chemical group 0.000 description 8
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 8
• 230000002829 reductive effect Effects 0.000 description 8
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 8
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 7
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 7
• 102100039360 Toll-like receptor 4 Human genes 0.000 description 7
• 238000007792 addition Methods 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 description 7
• 239000012230 colorless oil Substances 0.000 description 7
• 239000003085 diluting agent Substances 0.000 description 7
• 229940124669 imidazoquinoline Drugs 0.000 description 7
• 230000036039 immunity Effects 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 7
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 7
• 239000002245 particle Substances 0.000 description 7
• 230000003389 potentiating effect Effects 0.000 description 7
• 230000004936 stimulating effect Effects 0.000 description 7
• 235000000346 sugar Nutrition 0.000 description 7
• 238000002560 therapeutic procedure Methods 0.000 description 7
• 238000002255 vaccination Methods 0.000 description 7
• HUGDBOLAOLFPKW-KFMIKNBQSA-N (2R)-3-decanoyloxy-2-phenacyltetradecanoic acid Chemical compound CCCCCCCCCCCC([C@@H](CC(=O)C1=CC=CC=C1)C(=O)O)OC(=O)CCCCCCCCC HUGDBOLAOLFPKW-KFMIKNBQSA-N 0.000 description 6
• HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 description 6
• NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 6
• KPVQNXLUPNWQHM-RBEMOOQDSA-N 3-acetylpyridine adenine dinucleotide Chemical compound CC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 KPVQNXLUPNWQHM-RBEMOOQDSA-N 0.000 description 6
• FQKGSCOHCDSKAC-UHFFFAOYSA-N 4-[3-cyanopropyl(dimethoxy)silyl]butanenitrile Chemical compound N#CCCC[Si](OC)(CCCC#N)OC FQKGSCOHCDSKAC-UHFFFAOYSA-N 0.000 description 6
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
• 108010012236 Chemokines Proteins 0.000 description 6
• 102000019034 Chemokines Human genes 0.000 description 6
• 108020004414 DNA Proteins 0.000 description 6
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 6
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
• 238000010511 deprotection reaction Methods 0.000 description 6
• 230000002708 enhancing effect Effects 0.000 description 6
• 230000001900 immune effect Effects 0.000 description 6
• 239000010410 layer Substances 0.000 description 6
• 210000002540 macrophage Anatomy 0.000 description 6
• 230000001404 mediated effect Effects 0.000 description 6
• UOZZAMWODZQSOA-CQSZACIVSA-N methyl (3r)-3-hydroxytetradecanoate Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)OC UOZZAMWODZQSOA-CQSZACIVSA-N 0.000 description 6
• 239000012044 organic layer Substances 0.000 description 6
• 229940002612 prodrug Drugs 0.000 description 6
• 239000000651 prodrug Substances 0.000 description 6
• 230000000638 stimulation Effects 0.000 description 6
• 239000006188 syrup Substances 0.000 description 6
• 235000020357 syrup Nutrition 0.000 description 6
• 238000012360 testing method Methods 0.000 description 6
• 239000003053 toxin Substances 0.000 description 6
• 231100000765 toxin Toxicity 0.000 description 6
• 108700012359 toxins Proteins 0.000 description 6
• 239000013603 viral vector Substances 0.000 description 6
• NDCDVTWILZGAIG-HXUWFJFHSA-N (3r)-3-phenylmethoxytetradecanoic acid Chemical compound CCCCCCCCCCC[C@H](CC(O)=O)OCC1=CC=CC=C1 NDCDVTWILZGAIG-HXUWFJFHSA-N 0.000 description 5
• ATRNZOYKSNPPBF-CYBMUJFWSA-N (R)-3-hydroxytetradecanoic acid Chemical compound CCCCCCCCCCC[C@@H](O)CC(O)=O ATRNZOYKSNPPBF-CYBMUJFWSA-N 0.000 description 5
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 5
• 241000894006 Bacteria Species 0.000 description 5
• 101100454807 Caenorhabditis elegans lgg-1 gene Proteins 0.000 description 5
• 238000002965 ELISA Methods 0.000 description 5
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 5
• 206010020751 Hypersensitivity Diseases 0.000 description 5
• 102000013462 Interleukin-12 Human genes 0.000 description 5
• 108010065805 Interleukin-12 Proteins 0.000 description 5
• 208000004554 Leishmaniasis Diseases 0.000 description 5
• 241000223810 Plasmodium vivax Species 0.000 description 5
• 102100024333 Toll-like receptor 2 Human genes 0.000 description 5
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 5
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 5
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
• 230000004913 activation Effects 0.000 description 5
• 230000007815 allergy Effects 0.000 description 5
• 229940037003 alum Drugs 0.000 description 5
• 101150078331 ama-1 gene Proteins 0.000 description 5
• 238000004458 analytical method Methods 0.000 description 5
• 239000000872 buffer Substances 0.000 description 5
• 239000000969 carrier Substances 0.000 description 5
• 230000001413 cellular effect Effects 0.000 description 5
• 239000002274 desiccant Substances 0.000 description 5
• 239000003599 detergent Substances 0.000 description 5
• 239000003814 drug Substances 0.000 description 5
• 150000002148 esters Chemical class 0.000 description 5
• 239000011521 glass Substances 0.000 description 5
• 210000005260 human cell Anatomy 0.000 description 5
• 230000016784 immunoglobulin production Effects 0.000 description 5
• 230000015788 innate immune response Effects 0.000 description 5
• XSLAPWFITBDFTF-JOCHJYFZSA-N methyl (3r)-3-[(4-methoxyphenyl)methoxy]tetradecanoate Chemical compound CCCCCCCCCCC[C@H](CC(=O)OC)OCC1=CC=C(OC)C=C1 XSLAPWFITBDFTF-JOCHJYFZSA-N 0.000 description 5
• DSQRYVDYSWWRDB-OAQYLSRUSA-N methyl (3r)-3-phenylmethoxytetradecanoate Chemical compound CCCCCCCCCCC[C@H](CC(=O)OC)OCC1=CC=CC=C1 DSQRYVDYSWWRDB-OAQYLSRUSA-N 0.000 description 5
• 239000002480 mineral oil Substances 0.000 description 5
• 229940042472 mineral oil Drugs 0.000 description 5
• 235000010446 mineral oil Nutrition 0.000 description 5
• GWNIPPQZLLOJTO-HXUWFJFHSA-N phenacyl (3r)-3-hydroxytetradecanoate Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)OCC(=O)C1=CC=CC=C1 GWNIPPQZLLOJTO-HXUWFJFHSA-N 0.000 description 5
• 238000000746 purification Methods 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 239000003381 stabilizer Substances 0.000 description 5
• 239000004094 surface-active agent Substances 0.000 description 5
• 229940086542 triethylamine Drugs 0.000 description 5
• 239000003981 vehicle Substances 0.000 description 5
• AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 4
• OBECRJHRCDNGOR-OAQYLSRUSA-N (3r)-3-[(4-methoxyphenyl)methoxy]tetradecanoic acid Chemical compound CCCCCCCCCCC[C@H](CC(O)=O)OCC1=CC=C(OC)C=C1 OBECRJHRCDNGOR-OAQYLSRUSA-N 0.000 description 4
• HDNMEFKWYRFSJN-OAQYLSRUSA-N (3r)-3-[(4-methoxyphenyl)methoxy]tetradecanoyl chloride Chemical compound CCCCCCCCCCC[C@H](CC(Cl)=O)OCC1=CC=C(OC)C=C1 HDNMEFKWYRFSJN-OAQYLSRUSA-N 0.000 description 4
• WLNJGOIHOQOCJP-JOCHJYFZSA-N (3r)-3-decanoyloxytetradecanoic acid Chemical compound CCCCCCCCCCC[C@H](CC(O)=O)OC(=O)CCCCCCCCC WLNJGOIHOQOCJP-JOCHJYFZSA-N 0.000 description 4
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• 241000606161 Chlamydia Species 0.000 description 4
• OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
• 208000031886 HIV Infections Diseases 0.000 description 4
• 102000008070 Interferon-gamma Human genes 0.000 description 4
• 108010002350 Interleukin-2 Proteins 0.000 description 4
• 102000000588 Interleukin-2 Human genes 0.000 description 4
• 241000222722 Leishmania <genus> Species 0.000 description 4
• 102000008072 Lymphokines Human genes 0.000 description 4
• 108010074338 Lymphokines Proteins 0.000 description 4
• 241000186359 Mycobacterium Species 0.000 description 4
• 241001467552 Mycobacterium bovis BCG Species 0.000 description 4
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 4
• 108010057466 NF-kappa B Proteins 0.000 description 4
• 102000003945 NF-kappa B Human genes 0.000 description 4
• 108700023315 OspC Proteins 0.000 description 4
• 101100431670 Rattus norvegicus Ybx3 gene Proteins 0.000 description 4
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
• 229930006000 Sucrose Natural products 0.000 description 4
• 230000005867 T cell response Effects 0.000 description 4
• 206010047505 Visceral leishmaniasis Diseases 0.000 description 4
• 125000002252 acyl group Chemical group 0.000 description 4
• 208000026935 allergic disease Diseases 0.000 description 4
• 150000001413 amino acids Chemical class 0.000 description 4
• 230000005875 antibody response Effects 0.000 description 4
• 239000003963 antioxidant agent Substances 0.000 description 4
• 235000006708 antioxidants Nutrition 0.000 description 4
• 239000007864 aqueous solution Substances 0.000 description 4
• 230000001363 autoimmune Effects 0.000 description 4
• 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 4
• 125000004432 carbon atom Chemical group C* 0.000 description 4
• 150000002016 disaccharides Chemical group 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 239000000284 extract Substances 0.000 description 4
• 238000003818 flash chromatography Methods 0.000 description 4
• 230000004927 fusion Effects 0.000 description 4
• 230000001976 improved effect Effects 0.000 description 4
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
• 231100000252 nontoxic Toxicity 0.000 description 4
• 230000003000 nontoxic effect Effects 0.000 description 4
• NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 4
• 239000002953 phosphate buffered saline Substances 0.000 description 4
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
• 229920000053 polysorbate 80 Polymers 0.000 description 4
• 239000003755 preservative agent Substances 0.000 description 4
• 230000001681 protective effect Effects 0.000 description 4
• 239000000523 sample Substances 0.000 description 4
• 229910052938 sodium sulfate Inorganic materials 0.000 description 4
• 235000011152 sodium sulphate Nutrition 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• 230000009885 systemic effect Effects 0.000 description 4
• 229960000984 tocofersolan Drugs 0.000 description 4
• 231100000331 toxic Toxicity 0.000 description 4
• 230000002588 toxic effect Effects 0.000 description 4
• 241001529453 unidentified herpesvirus Species 0.000 description 4
• 241001430294 unidentified retrovirus Species 0.000 description 4
• IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 description 3
• ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
• 241000701022 Cytomegalovirus Species 0.000 description 3
• ATRNZOYKSNPPBF-UHFFFAOYSA-N D-beta-hydroxymyristic acid Natural products CCCCCCCCCCCC(O)CC(O)=O ATRNZOYKSNPPBF-UHFFFAOYSA-N 0.000 description 3
• 230000006820 DNA synthesis Effects 0.000 description 3
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 3
• 241000702421 Dependoparvovirus Species 0.000 description 3
• 241000224432 Entamoeba histolytica Species 0.000 description 3
• 241000588724 Escherichia coli Species 0.000 description 3
• BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 3
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 3
• 241000713666 Lentivirus Species 0.000 description 3
• 102000004895 Lipoproteins Human genes 0.000 description 3
• 108090001030 Lipoproteins Proteins 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• 241000224016 Plasmodium Species 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 101710188053 Protein D Proteins 0.000 description 3
• 101710132893 Resolvase Proteins 0.000 description 3
• 241000242683 Schistosoma haematobium Species 0.000 description 3
• 241000242677 Schistosoma japonicum Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 3
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
• 241000256856 Vespidae Species 0.000 description 3
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 3
• 229940087168 alpha tocopherol Drugs 0.000 description 3
• 229940024606 amino acid Drugs 0.000 description 3
• 235000001014 amino acid Nutrition 0.000 description 3
• 229910021529 ammonia Inorganic materials 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 239000012298 atmosphere Substances 0.000 description 3
• 230000005784 autoimmunity Effects 0.000 description 3
• 230000001580 bacterial effect Effects 0.000 description 3
• 230000006399 behavior Effects 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
• 210000000601 blood cell Anatomy 0.000 description 3
• HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 3
• 150000001720 carbohydrates Chemical class 0.000 description 3
• 235000014633 carbohydrates Nutrition 0.000 description 3
• 235000012000 cholesterol Nutrition 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 231100000517 death Toxicity 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical group [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 3
• 230000006334 disulfide bridging Effects 0.000 description 3
• 239000000975 dye Substances 0.000 description 3
• 229940011399 escin Drugs 0.000 description 3
• 229930186222 escin Natural products 0.000 description 3
• PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 description 3
• 239000013604 expression vector Substances 0.000 description 3
• 239000012634 fragment Substances 0.000 description 3
• 239000007789 gas Substances 0.000 description 3
• 150000004676 glycans Chemical class 0.000 description 3
• 239000001963 growth medium Substances 0.000 description 3
• 238000010438 heat treatment Methods 0.000 description 3
• 208000002672 hepatitis B Diseases 0.000 description 3
• 229940088597 hormone Drugs 0.000 description 3
• 239000005556 hormone Substances 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 150000007529 inorganic bases Chemical class 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 229940040692 lithium hydroxide monohydrate Drugs 0.000 description 3
• GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 3
• 238000012737 microarray-based gene expression Methods 0.000 description 3
• 239000004005 microsphere Substances 0.000 description 3
• 150000007522 mineralic acids Chemical class 0.000 description 3
• 201000006417 multiple sclerosis Diseases 0.000 description 3
• 238000012243 multiplex automated genomic engineering Methods 0.000 description 3
• 229930014626 natural product Natural products 0.000 description 3
• 239000002773 nucleotide Substances 0.000 description 3
• 125000003729 nucleotide group Chemical group 0.000 description 3
• 239000007764 o/w emulsion Substances 0.000 description 3
• 150000007524 organic acids Chemical class 0.000 description 3
• 150000007530 organic bases Chemical class 0.000 description 3
• 235000021317 phosphate Nutrition 0.000 description 3
• 210000002381 plasma Anatomy 0.000 description 3
• 239000004033 plastic Substances 0.000 description 3
• 229920003023 plastic Polymers 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
• 229920001282 polysaccharide Polymers 0.000 description 3
• 239000005017 polysaccharide Substances 0.000 description 3
• 238000011321 prophylaxis Methods 0.000 description 3
• 210000002307 prostate Anatomy 0.000 description 3
• 239000012047 saturated solution Substances 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 239000002002 slurry Substances 0.000 description 3
• 229910000104 sodium hydride Inorganic materials 0.000 description 3
• 208000024891 symptom Diseases 0.000 description 3
• 230000001225 therapeutic effect Effects 0.000 description 3
• 230000003612 virological effect Effects 0.000 description 3
• 239000011701 zinc Substances 0.000 description 3
• 229910052725 zinc Inorganic materials 0.000 description 3
• 235000004835 α-tocopherol Nutrition 0.000 description 3
• 239000002076 α-tocopherol Substances 0.000 description 3
• XOLCPJGQMDBKQJ-GAWVXTGCSA-N (2R)-2-phenacyl-3-tetradecanoyloxytetradecanoic acid Chemical compound CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)[C@@H](CC(=O)C1=CC=CC=C1)C(=O)O XOLCPJGQMDBKQJ-GAWVXTGCSA-N 0.000 description 2
• IYESSKQVAKTOQB-AREMUKBSSA-N (3r)-3-tetradecanoyloxytetradecanoic acid Chemical compound CCCCCCCCCCCCCC(=O)O[C@@H](CC(O)=O)CCCCCCCCCCC IYESSKQVAKTOQB-AREMUKBSSA-N 0.000 description 2
• HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 description 2
• MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 2
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
• GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 description 2
• IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 2
• WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 description 2
• KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 description 2
• UPQQXPKAYZYUKO-UHFFFAOYSA-N 2,2,2-trichloroacetamide Chemical compound OC(=N)C(Cl)(Cl)Cl UPQQXPKAYZYUKO-UHFFFAOYSA-N 0.000 description 2
• UNSAJINGUOTTRA-UHFFFAOYSA-N 3-(3-bromophenyl)prop-2-yn-1-ol Chemical compound OCC#CC1=CC=CC(Br)=C1 UNSAJINGUOTTRA-UHFFFAOYSA-N 0.000 description 2
• PBVZQAXFSQKDKK-UHFFFAOYSA-N 3-Methoxy-3-oxopropanoic acid Chemical compound COC(=O)CC(O)=O PBVZQAXFSQKDKK-UHFFFAOYSA-N 0.000 description 2
• FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
• 206010059313 Anogenital warts Diseases 0.000 description 2
• 208000023328 Basedow disease Diseases 0.000 description 2
• 108030001720 Bontoxilysin Proteins 0.000 description 2
• 241000588807 Bordetella Species 0.000 description 2
• 241000589968 Borrelia Species 0.000 description 2
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
• 241000222122 Candida albicans Species 0.000 description 2
• 241000193403 Clostridium Species 0.000 description 2
• 208000000907 Condylomata Acuminata Diseases 0.000 description 2
• 239000004375 Dextrin Substances 0.000 description 2
• 229920001353 Dextrin Polymers 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• 238000012286 ELISA Assay Methods 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• 241000713800 Feline immunodeficiency virus Species 0.000 description 2
• 241000233866 Fungi Species 0.000 description 2
• 241000224466 Giardia Species 0.000 description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
• 208000015023 Graves' disease Diseases 0.000 description 2
• 208000037357 HIV infectious disease Diseases 0.000 description 2
• 241000606768 Haemophilus influenzae Species 0.000 description 2
• 241000700721 Hepatitis B virus Species 0.000 description 2
• 241000238631 Hexapoda Species 0.000 description 2
• 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 description 2
• 241000701085 Human alphaherpesvirus 3 Species 0.000 description 2
• 241000701828 Human papillomavirus type 11 Species 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
• 241000257303 Hymenoptera Species 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 102000015696 Interleukins Human genes 0.000 description 2
• 108010063738 Interleukins Proteins 0.000 description 2
• 239000004166 Lanolin Substances 0.000 description 2
• 208000016604 Lyme disease Diseases 0.000 description 2
• 101710105759 Major outer membrane porin Proteins 0.000 description 2
• 101710164702 Major outer membrane protein Proteins 0.000 description 2
• 101710085938 Matrix protein Proteins 0.000 description 2
• 101710127721 Membrane protein Proteins 0.000 description 2
• 241001092142 Molina Species 0.000 description 2
• 208000031998 Mycobacterium Infections Diseases 0.000 description 2
• 241000186366 Mycobacterium bovis Species 0.000 description 2
• 241000186362 Mycobacterium leprae Species 0.000 description 2
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
• KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 241000588653 Neisseria Species 0.000 description 2
• 241000721454 Pemphigus Species 0.000 description 2
• 102100035181 Plastin-1 Human genes 0.000 description 2
• 241000233870 Pneumocystis Species 0.000 description 2
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 2
• 102100038358 Prostate-specific antigen Human genes 0.000 description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
• 241001454523 Quillaja saponaria Species 0.000 description 2
• 235000009001 Quillaja saponaria Nutrition 0.000 description 2
• 241000725643 Respiratory syncytial virus Species 0.000 description 2
• 208000036284 Rhinitis seasonal Diseases 0.000 description 2
• 241001134684 Rubrivivax gelatinosus Species 0.000 description 2
• 241000607142 Salmonella Species 0.000 description 2
• 241000242678 Schistosoma Species 0.000 description 2
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
• PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 2
• 229920002472 Starch Polymers 0.000 description 2
• 230000006052 T cell proliferation Effects 0.000 description 2
• 206010043561 Thrombocytopenic purpura Diseases 0.000 description 2
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 2
• 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 description 2
• 102100039387 Toll-like receptor 6 Human genes 0.000 description 2
• 102100033117 Toll-like receptor 9 Human genes 0.000 description 2
• 241000607479 Yersinia pestis Species 0.000 description 2
• LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 2
• LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 2
• SMNRFWMNPDABKZ-WVALLCKVSA-N [[(2R,3S,4R,5S)-5-(2,6-dioxo-3H-pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)C2C=CC(=O)NC2=O)[C@H](O)[C@@H](F)[C@@H]1O SMNRFWMNPDABKZ-WVALLCKVSA-N 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 125000003342 alkenyl group Chemical group 0.000 description 2
• 125000000304 alkynyl group Chemical group 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
• 229910052782 aluminium Inorganic materials 0.000 description 2
• 239000003708 ampul Substances 0.000 description 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
• 238000003782 apoptosis assay Methods 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 235000010323 ascorbic acid Nutrition 0.000 description 2
• 229960005070 ascorbic acid Drugs 0.000 description 2
• 239000011668 ascorbic acid Substances 0.000 description 2
• 208000006673 asthma Diseases 0.000 description 2
• 230000002238 attenuated effect Effects 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 244000052616 bacterial pathogen Species 0.000 description 2
• 229960001212 bacterial vaccine Drugs 0.000 description 2
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
• 229920002988 biodegradable polymer Polymers 0.000 description 2
• 239000004621 biodegradable polymer Substances 0.000 description 2
• 239000013060 biological fluid Substances 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 229920001400 block copolymer Polymers 0.000 description 2
• 229940053031 botulinum toxin Drugs 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 229960005084 calcitriol Drugs 0.000 description 2
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 2
• 239000003054 catalyst Substances 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 230000036755 cellular response Effects 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• QUWFSKKBMDKAHK-SBOJBMMISA-A chembl2103793 Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)CO)[C@@H](O)C1 QUWFSKKBMDKAHK-SBOJBMMISA-A 0.000 description 2
• 239000003086 colorant Substances 0.000 description 2
• 239000000356 contaminant Substances 0.000 description 2
• 230000016396 cytokine production Effects 0.000 description 2
• 230000001461 cytolytic effect Effects 0.000 description 2
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
• IPIVAXLHTVNRBS-UHFFFAOYSA-N decanoyl chloride Chemical compound CCCCCCCCCC(Cl)=O IPIVAXLHTVNRBS-UHFFFAOYSA-N 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 235000019425 dextrin Nutrition 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 238000010790 dilution Methods 0.000 description 2
• 239000012895 dilution Substances 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
• 229940007078 entamoeba histolytica Drugs 0.000 description 2
• 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 2
• 210000003743 erythrocyte Anatomy 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• IRXSLJNXXZKURP-UHFFFAOYSA-N fluorenylmethyloxycarbonyl chloride Chemical compound C1=CC=C2C(COC(=O)Cl)C3=CC=CC=C3C2=C1 IRXSLJNXXZKURP-UHFFFAOYSA-N 0.000 description 2
• 235000013355 food flavoring agent Nutrition 0.000 description 2
• 235000019253 formic acid Nutrition 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• 229940044627 gamma-interferon Drugs 0.000 description 2
• 229960002442 glucosamine Drugs 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 235000011187 glycerol Nutrition 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 229940029575 guanosine Drugs 0.000 description 2
• 230000002949 hemolytic effect Effects 0.000 description 2
• 102000022382 heparin binding proteins Human genes 0.000 description 2
• 108091012216 heparin binding proteins Proteins 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 231100000283 hepatitis Toxicity 0.000 description 2
• 238000004128 high performance liquid chromatography Methods 0.000 description 2
• 235000010181 horse chestnut Nutrition 0.000 description 2
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 230000002163 immunogen Effects 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 239000002955 immunomodulating agent Substances 0.000 description 2
• 229940121354 immunomodulator Drugs 0.000 description 2
• 229960001438 immunostimulant agent Drugs 0.000 description 2
• 239000003022 immunostimulating agent Substances 0.000 description 2
• 239000012535 impurity Substances 0.000 description 2
• 210000005007 innate immune system Anatomy 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 229960003130 interferon gamma Drugs 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 239000004310 lactic acid Substances 0.000 description 2
• 235000014655 lactic acid Nutrition 0.000 description 2
• 229940039717 lanolin Drugs 0.000 description 2
• 235000019388 lanolin Nutrition 0.000 description 2
• 238000011031 large-scale manufacturing process Methods 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 210000004698 lymphocyte Anatomy 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 229940124735 malaria vaccine Drugs 0.000 description 2
• 239000002609 medium Substances 0.000 description 2
• 201000001441 melanoma Diseases 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 230000004060 metabolic process Effects 0.000 description 2
• LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
• 230000000813 microbial effect Effects 0.000 description 2
• 235000010755 mineral Nutrition 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• 239000002808 molecular sieve Substances 0.000 description 2
• 230000004899 motility Effects 0.000 description 2
• 208000027531 mycobacterial infectious disease Diseases 0.000 description 2
• JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
• 239000004006 olive oil Substances 0.000 description 2
• 235000008390 olive oil Nutrition 0.000 description 2
• CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 2
• 230000008506 pathogenesis Effects 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 2
• 108010049148 plastin Proteins 0.000 description 2
• 201000000317 pneumocystosis Diseases 0.000 description 2
• 229920000747 poly(lactic acid) Polymers 0.000 description 2
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
• 229940068917 polyethylene glycols Drugs 0.000 description 2
• 229920000136 polysorbate Polymers 0.000 description 2
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 230000005522 programmed cell death Effects 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• GRJJQCWNZGRKAU-UHFFFAOYSA-N pyridin-1-ium;fluoride Chemical compound F.C1=CC=NC=C1 GRJJQCWNZGRKAU-UHFFFAOYSA-N 0.000 description 2
• 238000003127 radioimmunoassay Methods 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 230000009467 reduction Effects 0.000 description 2
• 238000010992 reflux Methods 0.000 description 2
• 206010039073 rheumatoid arthritis Diseases 0.000 description 2
• 230000003248 secreting effect Effects 0.000 description 2
• 230000035945 sensitivity Effects 0.000 description 2
• 238000013207 serial dilution Methods 0.000 description 2
• 230000019491 signal transduction Effects 0.000 description 2
• 239000000377 silicon dioxide Substances 0.000 description 2
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
• 235000017557 sodium bicarbonate Nutrition 0.000 description 2
• 239000012312 sodium hydride Substances 0.000 description 2
• 239000007790 solid phase Substances 0.000 description 2
• 239000012453 solvate Substances 0.000 description 2
• 210000004988 splenocyte Anatomy 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 229940032094 squalane Drugs 0.000 description 2
• 239000008107 starch Substances 0.000 description 2
• 235000019698 starch Nutrition 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 239000007929 subcutaneous injection Substances 0.000 description 2
• 239000000375 suspending agent Substances 0.000 description 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
• 125000003396 thiol group Chemical group [H]S* 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 2
• 241000712461 unidentified influenza virus Species 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• ABJSOROVZZKJGI-OCYUSGCXSA-N (1r,2r,4r)-2-(4-bromophenyl)-n-[(4-chlorophenyl)-(2-fluoropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide Chemical compound C1=NC(F)=CC(C(NC(=O)[C@H]2[C@@H](C[C@@H](CC2)N2CCOCC2)C=2C=CC(Br)=CC=2)C=2C=CC(Cl)=CC=2)=C1 ABJSOROVZZKJGI-OCYUSGCXSA-N 0.000 description 1
• YSTCVEONORJQDG-KWRHIPAJSA-N (2r)-2-benzyl-3-tetradecanoyloxytetradecanoic acid Chemical compound CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)[C@H](C(O)=O)CC1=CC=CC=C1 YSTCVEONORJQDG-KWRHIPAJSA-N 0.000 description 1
• ITOFPJRDSCGOSA-KZLRUDJFSA-N (2s)-2-[[(4r)-4-[(3r,5r,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H](CC[C@]13C)[C@@H]2[C@@H]3CC[C@@H]1[C@H](C)CCC(=O)N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12 ITOFPJRDSCGOSA-KZLRUDJFSA-N 0.000 description 1
• WWTBZEKOSBFBEM-SPWPXUSOSA-N (2s)-2-[[2-benzyl-3-[hydroxy-[(1r)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)O)C(=O)C(CP(O)(=O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1 WWTBZEKOSBFBEM-SPWPXUSOSA-N 0.000 description 1
• YFESOSRPNPYODN-RSMWSHJLSA-N (2s,3s,4s,5r,6r)-6-[[(4s,6ar,6bs,8r,8ar,9r,10r,14br)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2s,3r,4s, Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YFESOSRPNPYODN-RSMWSHJLSA-N 0.000 description 1
• CUZUQBXUDNWBRB-HXUWFJFHSA-N (3r)-3-phenylmethoxytetradecanoyl chloride Chemical compound CCCCCCCCCCC[C@H](CC(Cl)=O)OCC1=CC=CC=C1 CUZUQBXUDNWBRB-HXUWFJFHSA-N 0.000 description 1
• JXXQHXVCIPCYSW-XMMPIXPASA-N (3r)-4-oxo-3-undecylpentadecanoic acid Chemical compound CCCCCCCCCCC[C@H](CC(O)=O)C(=O)CCCCCCCCCCC JXXQHXVCIPCYSW-XMMPIXPASA-N 0.000 description 1
• LCTORNIWLGOBPB-GASJEMHNSA-N (3r,4s,5s,6r)-2-amino-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound NC1(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O LCTORNIWLGOBPB-GASJEMHNSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• TYHGKLBJBHACOI-UHFFFAOYSA-N (4-methoxyphenyl)methyl 2,2,2-trichloroethanimidate Chemical compound COC1=CC=C(COC(=N)C(Cl)(Cl)Cl)C=C1 TYHGKLBJBHACOI-UHFFFAOYSA-N 0.000 description 1
• HEVMDQBCAHEHDY-UHFFFAOYSA-N (Dimethoxymethyl)benzene Chemical compound COC(OC)C1=CC=CC=C1 HEVMDQBCAHEHDY-UHFFFAOYSA-N 0.000 description 1
• UVNPEUJXKZFWSJ-LMTQTHQJSA-N (R)-N-[(4S)-8-[6-amino-5-[(3,3-difluoro-2-oxo-1H-pyrrolo[2,3-b]pyridin-4-yl)sulfanyl]pyrazin-2-yl]-2-oxa-8-azaspiro[4.5]decan-4-yl]-2-methylpropane-2-sulfinamide Chemical compound CC(C)(C)[S@@](=O)N[C@@H]1COCC11CCN(CC1)c1cnc(Sc2ccnc3NC(=O)C(F)(F)c23)c(N)n1 UVNPEUJXKZFWSJ-LMTQTHQJSA-N 0.000 description 1
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
• XFQPQSJDMJVOBN-UHFFFAOYSA-N 1-[4-amino-2-(ethylaminomethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.C1=CC=CC2=C(N(C(CNCC)=N3)CC(C)(C)O)C3=C(N)N=C21 XFQPQSJDMJVOBN-UHFFFAOYSA-N 0.000 description 1
• 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 description 1
• 125000004972 1-butynyl group Chemical group [H]C([H])([H])C([H])([H])C#C* 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• 125000006023 1-pentenyl group Chemical group 0.000 description 1
• 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
• GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 1
• 125000006069 2,3-dimethyl-2-butenyl group Chemical group 0.000 description 1
• MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
• YSUIQYOGTINQIN-UZFYAQMZSA-N 2-amino-9-[(1S,6R,8R,9S,10R,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-difluoro-3,12-dihydroxy-3,12-bis(sulfanylidene)-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one Chemical compound NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(S)(=O)O[C@@H]4[C@@H](COP(S)(=O)O[C@@H]2[C@@H]3F)O[C@H]([C@H]4F)N2C=NC3=C2N=CN=C3N)C(=O)N1 YSUIQYOGTINQIN-UZFYAQMZSA-N 0.000 description 1
• 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
• 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
• 125000006029 2-methyl-2-butenyl group Chemical group 0.000 description 1
• 125000006024 2-pentenyl group Chemical group 0.000 description 1
• ASCFNMCAHFUBCO-UHFFFAOYSA-N 2-phosphoglycolic acid Chemical compound OC(=O)COP(O)(O)=O ASCFNMCAHFUBCO-UHFFFAOYSA-N 0.000 description 1
• FTZIQBGFCYJWKA-UHFFFAOYSA-N 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Chemical compound S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 FTZIQBGFCYJWKA-UHFFFAOYSA-N 0.000 description 1
• 125000006027 3-methyl-1-butenyl group Chemical group 0.000 description 1
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
• 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
• 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 description 1
• RVDLHGSZWAELAU-UHFFFAOYSA-N 5-tert-butylthiophene-2-carbonyl chloride Chemical compound CC(C)(C)C1=CC=C(C(Cl)=O)S1 RVDLHGSZWAELAU-UHFFFAOYSA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• 241000224422 Acanthamoeba Species 0.000 description 1
• 241000238876 Acari Species 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 description 1
• 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 description 1
• 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 description 1
• 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 description 1
• 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 description 1
• 241000456624 Actinobacteria bacterium Species 0.000 description 1
• AXNVHPCVMSNXNP-GKTCLTPXSA-N Aescin Natural products O=C(O[C@H]1[C@@H](OC(=O)C)[C@]2(CO)[C@@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O7)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC1(C)C)/C(=C/C)/C AXNVHPCVMSNXNP-GKTCLTPXSA-N 0.000 description 1
• 241000157282 Aesculus Species 0.000 description 1
• 241000157280 Aesculus hippocastanum Species 0.000 description 1
• 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 description 1
• 208000000884 Airway Obstruction Diseases 0.000 description 1
• 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 description 1
• 206010027654 Allergic conditions Diseases 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 206010001935 American trypanosomiasis Diseases 0.000 description 1
• 241001147657 Ancylostoma Species 0.000 description 1
• 241000498253 Ancylostoma duodenale Species 0.000 description 1
• 241000243791 Angiostrongylus Species 0.000 description 1
• 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 description 1
• 241000256186 Anopheles <genus> Species 0.000 description 1
• 101100162403 Arabidopsis thaliana ALEU gene Proteins 0.000 description 1
• 240000005528 Arctium lappa Species 0.000 description 1
• 241000244185 Ascaris lumbricoides Species 0.000 description 1
• 241000228212 Aspergillus Species 0.000 description 1
• 206010050245 Autoimmune thrombocytopenia Diseases 0.000 description 1
• 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 description 1
• 102100035526 B melanoma antigen 1 Human genes 0.000 description 1
• 241000223836 Babesia Species 0.000 description 1
• 241000193830 Bacillus <bacterium> Species 0.000 description 1
• 241000193738 Bacillus anthracis Species 0.000 description 1
• 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 description 1
• 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 description 1
• 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 description 1
• 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 description 1
• 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 description 1
• 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 description 1
• 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 description 1
• 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 description 1
• 108020000946 Bacterial DNA Proteins 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 241000335423 Blastomyces Species 0.000 description 1
• 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 description 1
• 241000588779 Bordetella bronchiseptica Species 0.000 description 1
• 241000588780 Bordetella parapertussis Species 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 241000589978 Borrelia hermsii Species 0.000 description 1
• 241000495356 Borrelia microti Species 0.000 description 1
• 241000589972 Borrelia sp. Species 0.000 description 1
• 241001148604 Borreliella afzelii Species 0.000 description 1
• 241000142472 Borreliella andersonii Species 0.000 description 1
• 241000589969 Borreliella burgdorferi Species 0.000 description 1
• 241001148605 Borreliella garinii Species 0.000 description 1
• 241000589893 Brachyspira hyodysenteriae Species 0.000 description 1
• 206010006187 Breast cancer Diseases 0.000 description 1
• 208000026310 Breast neoplasm Diseases 0.000 description 1
• 206010006458 Bronchitis chronic Diseases 0.000 description 1
• 241000244038 Brugia malayi Species 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 238000011740 C57BL/6 mouse Methods 0.000 description 1
• KCBAMQOKOLXLOX-BSZYMOERSA-N CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNCCCONC(=O)C4=C(C(=C(C=C4)F)F)NC5=C(C=C(C=C5)I)F)O Chemical compound CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNCCCONC(=O)C4=C(C(=C(C=C4)F)F)NC5=C(C=C(C=C5)I)F)O KCBAMQOKOLXLOX-BSZYMOERSA-N 0.000 description 1
• 101100131403 Caenorhabditis elegans msp-142 gene Proteins 0.000 description 1
• 244000197813 Camelina sativa Species 0.000 description 1
• 241000589876 Campylobacter Species 0.000 description 1
• 241000589877 Campylobacter coli Species 0.000 description 1
• 241000589875 Campylobacter jejuni Species 0.000 description 1
• 241000222173 Candida parapsilosis Species 0.000 description 1
• 241000222178 Candida tropicalis Species 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 102100035882 Catalase Human genes 0.000 description 1
• 108010053835 Catalase Proteins 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 208000026368 Cestode infections Diseases 0.000 description 1
• 208000022636 Cestode infectious disease Diseases 0.000 description 1
• 102000001326 Chemokine CCL4 Human genes 0.000 description 1
• 108010055165 Chemokine CCL4 Proteins 0.000 description 1
• 108010055166 Chemokine CCL5 Proteins 0.000 description 1
• 102000001327 Chemokine CCL5 Human genes 0.000 description 1
• 241001647372 Chlamydia pneumoniae Species 0.000 description 1
• 241001647378 Chlamydia psittaci Species 0.000 description 1
• 241000606153 Chlamydia trachomatis Species 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 description 1
• 241001508813 Clavispora lusitaniae Species 0.000 description 1
• 241000193163 Clostridioides difficile Species 0.000 description 1
• 241000193155 Clostridium botulinum Species 0.000 description 1
• 241000193449 Clostridium tetani Species 0.000 description 1
• 241000223203 Coccidioides Species 0.000 description 1
• 206010010071 Coma Diseases 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 229940126657 Compound 17 Drugs 0.000 description 1
• 229940126639 Compound 33 Drugs 0.000 description 1
• 206010010305 Confusional state Diseases 0.000 description 1
• 206010010904 Convulsion Diseases 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• 241000186216 Corynebacterium Species 0.000 description 1
• 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 206010011224 Cough Diseases 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
• 241000221204 Cryptococcus neoformans Species 0.000 description 1
• 241000223935 Cryptosporidium Species 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 101710088194 Dehydrogenase Proteins 0.000 description 1
• 102100031262 Deleted in malignant brain tumors 1 protein Human genes 0.000 description 1
• 241000725619 Dengue virus Species 0.000 description 1
• 238000009007 Diagnostic Kit Methods 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 240000001879 Digitalis lutea Species 0.000 description 1
• QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 description 1
• 108010053187 Diphtheria Toxin Proteins 0.000 description 1
• 102000016607 Diphtheria Toxin Human genes 0.000 description 1
• 241000255925 Diptera Species 0.000 description 1
• SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
• 206010059866 Drug resistance Diseases 0.000 description 1
• 241000605314 Ehrlichia Species 0.000 description 1
• 206010014561 Emphysema Diseases 0.000 description 1
• 241000224431 Entamoeba Species 0.000 description 1
• 241000146407 Entamoeba coli Species 0.000 description 1
• 241000204733 Entamoeba dispar Species 0.000 description 1
• 241001133638 Entamoeba equi Species 0.000 description 1
• 241000146401 Entamoeba hartmanni Species 0.000 description 1
• 241000146402 Entamoeba polecki Species 0.000 description 1
• 241000305071 Enterobacterales Species 0.000 description 1
• 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 description 1
• 241000498255 Enterobius vermicularis Species 0.000 description 1
• 241000194033 Enterococcus Species 0.000 description 1
• 241000194032 Enterococcus faecalis Species 0.000 description 1
• 241000194031 Enterococcus faecium Species 0.000 description 1
• 241000991587 Enterovirus C Species 0.000 description 1
• 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 description 1
• 241000588722 Escherichia Species 0.000 description 1
• 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 description 1
• 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 description 1
• 239000001856 Ethyl cellulose Substances 0.000 description 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
• 241000204939 Fasciola gigantica Species 0.000 description 1
• 241000242711 Fasciola hepatica Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 101710154643 Filamentous hemagglutinin Proteins 0.000 description 1
• 108010040721 Flagellin Proteins 0.000 description 1
• 241000710831 Flavivirus Species 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 description 1
• 108091006027 G proteins Proteins 0.000 description 1
• 102000030782 GTP binding Human genes 0.000 description 1
• 108091000058 GTP-Binding Proteins 0.000 description 1
• 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 description 1
• 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 description 1
• 241000224467 Giardia intestinalis Species 0.000 description 1
• 229920001503 Glucan Polymers 0.000 description 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 229930186217 Glycolipid Natural products 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 229920002683 Glycosaminoglycan Polymers 0.000 description 1
• NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 description 1
• 241001316290 Gypsophila Species 0.000 description 1
• 229940033330 HIV vaccine Drugs 0.000 description 1
• 241000606790 Haemophilus Species 0.000 description 1
• 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 description 1
• 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 description 1
• 101100406392 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) omp26 gene Proteins 0.000 description 1
• 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 description 1
• 208000001204 Hashimoto Disease Diseases 0.000 description 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
• 206010019233 Headaches Diseases 0.000 description 1
• 241000589989 Helicobacter Species 0.000 description 1
• 108010034145 Helminth Proteins Proteins 0.000 description 1
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 241000711549 Hepacivirus C Species 0.000 description 1
• 229940124872 Hepatitis B virus vaccine Drugs 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 241000724675 Hepatitis E virus Species 0.000 description 1
• 241000709721 Hepatovirus A Species 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 description 1
• 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
• 101000844721 Homo sapiens Deleted in malignant brain tumors 1 protein Proteins 0.000 description 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 1
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
• 101000874141 Homo sapiens Probable ATP-dependent RNA helicase DDX43 Proteins 0.000 description 1
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 1
• 101001130441 Homo sapiens Ras-related protein Rap-2a Proteins 0.000 description 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
• 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 description 1
• 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 description 1
• 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
• 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
• 206010071038 Human anaplasmosis Diseases 0.000 description 1
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
• 241000341655 Human papillomavirus type 16 Species 0.000 description 1
• 206010022004 Influenza like illness Diseases 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 108090000174 Interleukin-10 Proteins 0.000 description 1
• 108090000176 Interleukin-13 Proteins 0.000 description 1
• 101800003050 Interleukin-16 Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 108090000978 Interleukin-4 Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 102000000704 Interleukin-7 Human genes 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 206010022998 Irritability Diseases 0.000 description 1
• 241000710842 Japanese encephalitis virus Species 0.000 description 1
• 206010023126 Jaundice Diseases 0.000 description 1
• 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 description 1
• 102100034872 Kallikrein-4 Human genes 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 102100032241 Lactotransferrin Human genes 0.000 description 1
• 239000005639 Lauric acid Substances 0.000 description 1
• 241000589248 Legionella Species 0.000 description 1
• 241000589242 Legionella pneumophila Species 0.000 description 1
• 208000007764 Legionnaires' Disease Diseases 0.000 description 1
• 206010057168 Leishmania infections Diseases 0.000 description 1
• 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 description 1
• 241000589902 Leptospira Species 0.000 description 1
• 241000589929 Leptospira interrogans Species 0.000 description 1
• 241000186781 Listeria Species 0.000 description 1
• 241000186779 Listeria monocytogenes Species 0.000 description 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 241000712079 Measles morbillivirus Species 0.000 description 1
• 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 1
• 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 description 1
• 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 description 1
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
• 241000588621 Moraxella Species 0.000 description 1
• 241000588655 Moraxella catarrhalis Species 0.000 description 1
• 241000711386 Mumps virus Species 0.000 description 1
• 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 description 1
• 241000501454 Mutillidae Species 0.000 description 1
• 208000000112 Myalgia Diseases 0.000 description 1
• 241000186367 Mycobacterium avium Species 0.000 description 1
• 241000187482 Mycobacterium avium subsp. paratuberculosis Species 0.000 description 1
• 241000187480 Mycobacterium smegmatis Species 0.000 description 1
• 241000694696 Mycobacterium tuberculosis CAS Species 0.000 description 1
• 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 description 1
• OPFJDXRVMFKJJO-ZHHKINOHSA-N N-{[3-(2-benzamido-4-methyl-1,3-thiazol-5-yl)-pyrazol-5-yl]carbonyl}-G-dR-G-dD-dD-dD-NH2 Chemical compound S1C(C=2NN=C(C=2)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(N)=O)=C(C)N=C1NC(=O)C1=CC=CC=C1 OPFJDXRVMFKJJO-ZHHKINOHSA-N 0.000 description 1
• 241001644525 Nastus productus Species 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• 241000498270 Necator americanus Species 0.000 description 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
• 241000588650 Neisseria meningitidis Species 0.000 description 1
• 208000000291 Nematode infections Diseases 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• HCUVEUVIUAJXRB-UHFFFAOYSA-N OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC Chemical compound OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC HCUVEUVIUAJXRB-UHFFFAOYSA-N 0.000 description 1
• 241000243985 Onchocerca volvulus Species 0.000 description 1
• 241000133504 Opisthorchis sinensis Species 0.000 description 1
• 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 description 1
• 101710116435 Outer membrane protein Proteins 0.000 description 1
• 108060006580 PRAME Proteins 0.000 description 1
• 102000036673 PRAME Human genes 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 1
• 241001480233 Paragonimus Species 0.000 description 1
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
• 208000030852 Parasitic disease Diseases 0.000 description 1
• 101150111072 Pars2 gene Proteins 0.000 description 1
• 206010034133 Pathogen resistance Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 208000031845 Pernicious anaemia Diseases 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• 239000004264 Petrolatum Substances 0.000 description 1
• 241000255129 Phlebotominae Species 0.000 description 1
• 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 description 1
• 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 description 1
• 235000014676 Phragmites communis Nutrition 0.000 description 1
• 241000235645 Pichia kudriavzevii Species 0.000 description 1
• 101000983333 Plasmodium falciparum (isolate NF54) 25 kDa ookinete surface antigen Proteins 0.000 description 1
• 241000223821 Plasmodium malariae Species 0.000 description 1
• 206010035501 Plasmodium malariae infection Diseases 0.000 description 1
• 241001505293 Plasmodium ovale Species 0.000 description 1
• 206010035502 Plasmodium ovale infection Diseases 0.000 description 1
• 241000233872 Pneumocystis carinii Species 0.000 description 1
• 101710183389 Pneumolysin Proteins 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 102100035724 Probable ATP-dependent RNA helicase DDX43 Human genes 0.000 description 1
• 102100036735 Prostate stem cell antigen Human genes 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 102000016611 Proteoglycans Human genes 0.000 description 1
• 108010067787 Proteoglycans Proteins 0.000 description 1
• 108010010974 Proteolipids Proteins 0.000 description 1
• 102000016202 Proteolipids Human genes 0.000 description 1
• 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 description 1
• 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 description 1
• 101710201576 Putative membrane protein Proteins 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• 102100022851 Rab5 GDP/GTP exchange factor Human genes 0.000 description 1
• 102100031420 Ras-related protein Rap-2a Human genes 0.000 description 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 208000001647 Renal Insufficiency Diseases 0.000 description 1
• 101710203837 Replication-associated protein Proteins 0.000 description 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
• 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 description 1
• 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 description 1
• 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 description 1
• 235000019774 Rice Bran oil Nutrition 0.000 description 1
• 241000606701 Rickettsia Species 0.000 description 1
• 241000606695 Rickettsia rickettsii Species 0.000 description 1
• 241000702670 Rotavirus Species 0.000 description 1
• 101000999689 Saimiriine herpesvirus 2 (strain 11) Transcriptional regulator ICP22 homolog Proteins 0.000 description 1
• 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 description 1
• 241001138501 Salmonella enterica Species 0.000 description 1
• 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
• 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
• 241000607149 Salmonella sp. Species 0.000 description 1
• 241000219287 Saponaria Species 0.000 description 1
• 241000242680 Schistosoma mansoni Species 0.000 description 1
• 241001520868 Schistosoma mekongi Species 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 208000034189 Sclerosis Diseases 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 241000607764 Shigella dysenteriae Species 0.000 description 1
• 241000607760 Shigella sonnei Species 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• PNUZDKCDAWUEGK-CYZMBNFOSA-N Sitafloxacin Chemical compound C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 PNUZDKCDAWUEGK-CYZMBNFOSA-N 0.000 description 1
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 241000191963 Staphylococcus epidermidis Species 0.000 description 1
• 229930182558 Sterol Natural products 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 241000193985 Streptococcus agalactiae Species 0.000 description 1
• 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 description 1
• 241000194019 Streptococcus mutans Species 0.000 description 1
• 241000193996 Streptococcus pyogenes Species 0.000 description 1
• 108010011834 Streptolysins Proteins 0.000 description 1
• 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 description 1
• 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 description 1
• 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 description 1
• 241000244177 Strongyloides stercoralis Species 0.000 description 1
• 101710172711 Structural protein Proteins 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
• 101710137302 Surface antigen S Proteins 0.000 description 1
• 108010002687 Survivin Proteins 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 229940124614 TLR 8 agonist Drugs 0.000 description 1
• 108700012920 TNF Proteins 0.000 description 1
• 241000244159 Taenia saginata Species 0.000 description 1
• 241000244157 Taenia solium Species 0.000 description 1
• 206010043376 Tetanus Diseases 0.000 description 1
• 108010055044 Tetanus Toxin Proteins 0.000 description 1
• 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 description 1
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 208000024799 Thyroid disease Diseases 0.000 description 1
• 241000710771 Tick-borne encephalitis virus Species 0.000 description 1
• 102100024324 Toll-like receptor 3 Human genes 0.000 description 1
• 102100039357 Toll-like receptor 5 Human genes 0.000 description 1
• 102100039390 Toll-like receptor 7 Human genes 0.000 description 1
• QMGSCYSTMWRURP-UHFFFAOYSA-N Tomatine Natural products CC1CCC2(NC1)OC3CC4C5CCC6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(O)C%10O)C8O)C(O)C7O QMGSCYSTMWRURP-UHFFFAOYSA-N 0.000 description 1
• 241000223996 Toxoplasma Species 0.000 description 1
• 241000223997 Toxoplasma gondii Species 0.000 description 1
• 101710134694 Transcriptional regulator ICP22 homolog Proteins 0.000 description 1
• 102000010912 Transferrin-Binding Proteins Human genes 0.000 description 1
• 108010062476 Transferrin-Binding Proteins Proteins 0.000 description 1
• 241000242541 Trematoda Species 0.000 description 1
• 208000004938 Trematode Infections Diseases 0.000 description 1
• 241000589886 Treponema Species 0.000 description 1
• 241000589892 Treponema denticola Species 0.000 description 1
• 241000589884 Treponema pallidum Species 0.000 description 1
• 241000243777 Trichinella spiralis Species 0.000 description 1
• DRUIESSIVFYOMK-UHFFFAOYSA-N Trichloroacetonitrile Chemical compound ClC(Cl)(Cl)C#N DRUIESSIVFYOMK-UHFFFAOYSA-N 0.000 description 1
• 241000224526 Trichomonas Species 0.000 description 1
• 241000224527 Trichomonas vaginalis Species 0.000 description 1
• 241001489151 Trichuris Species 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 244000098338 Triticum aestivum Species 0.000 description 1
• 241000223104 Trypanosoma Species 0.000 description 1
• 241000223109 Trypanosoma cruzi Species 0.000 description 1
• 102000003425 Tyrosinase Human genes 0.000 description 1
• 108060008724 Tyrosinase Proteins 0.000 description 1
• 108010046334 Urease Proteins 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 241000607598 Vibrio Species 0.000 description 1
• 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 description 1
• 229930003427 Vitamin E Natural products 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 241000244005 Wuchereria bancrofti Species 0.000 description 1
• 241000710772 Yellow fever virus Species 0.000 description 1
• 241000607734 Yersinia <bacteria> Species 0.000 description 1
• 241000607447 Yersinia enterocolitica Species 0.000 description 1
• 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
• 241000606834 [Haemophilus] ducreyi Species 0.000 description 1
• WREOTYWODABZMH-DTZQCDIJSA-N [[(2r,3s,4r,5r)-3,4-dihydroxy-5-[2-oxo-4-(2-phenylethoxyamino)pyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N(C=C\1)C(=O)NC/1=N\OCCC1=CC=CC=C1 WREOTYWODABZMH-DTZQCDIJSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 150000001241 acetals Chemical class 0.000 description 1
• 150000001242 acetic acid derivatives Chemical class 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 102000030621 adenylate cyclase Human genes 0.000 description 1
• 108060000200 adenylate cyclase Proteins 0.000 description 1
• 230000000240 adjuvant effect Effects 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000008484 agonism Effects 0.000 description 1
• 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
• 229930013930 alkaloid Natural products 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 239000010775 animal oil Substances 0.000 description 1
• 208000025009 anogenital human papillomavirus infection Diseases 0.000 description 1
• 201000004201 anogenital venereal wart Diseases 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 230000036436 anti-hiv Effects 0.000 description 1
• 230000001355 anti-mycobacterial effect Effects 0.000 description 1
• 208000037908 antibody-mediated disorder Diseases 0.000 description 1
• 210000000612 antigen-presenting cell Anatomy 0.000 description 1
• 230000008350 antigen-specific antibody response Effects 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 239000013011 aqueous formulation Substances 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 150000001540 azides Chemical class 0.000 description 1
• 210000002769 b effector cell Anatomy 0.000 description 1
• 201000008680 babesiosis Diseases 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 235000013871 bee wax Nutrition 0.000 description 1
• 239000012166 beeswax Substances 0.000 description 1
• 229940092738 beeswax Drugs 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
• 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• HUZCTWYDQIQZPM-UHFFFAOYSA-N benzyl 2,2,2-trichloroethanimidate Chemical compound ClC(Cl)(Cl)C(=N)OCC1=CC=CC=C1 HUZCTWYDQIQZPM-UHFFFAOYSA-N 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000012472 biological sample Substances 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 238000001815 biotherapy Methods 0.000 description 1
• 239000012455 biphasic mixture Substances 0.000 description 1
• 201000001531 bladder carcinoma Diseases 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 244000309464 bull Species 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 230000003185 calcium uptake Effects 0.000 description 1
• 125000000837 carbohydrate group Chemical group 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 150000007942 carboxylates Chemical class 0.000 description 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
• 238000000423 cell based assay Methods 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 235000013339 cereals Nutrition 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• 108091016312 choline binding proteins Proteins 0.000 description 1
• 208000007451 chronic bronchitis Diseases 0.000 description 1
• 208000037976 chronic inflammation Diseases 0.000 description 1
• 230000006020 chronic inflammation Effects 0.000 description 1
• 150000001860 citric acid derivatives Chemical class 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 238000004737 colorimetric analysis Methods 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 229940000425 combination drug Drugs 0.000 description 1
• 229940125758 compound 15 Drugs 0.000 description 1
• 229940126142 compound 16 Drugs 0.000 description 1
• 229940125782 compound 2 Drugs 0.000 description 1
• 229940125810 compound 20 Drugs 0.000 description 1
• 229940126086 compound 21 Drugs 0.000 description 1
• 229940126208 compound 22 Drugs 0.000 description 1
• 229940125833 compound 23 Drugs 0.000 description 1
• 229940126214 compound 3 Drugs 0.000 description 1
• 229940125898 compound 5 Drugs 0.000 description 1
• 239000003636 conditioned culture medium Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 201000003278 cryoglobulinemia Diseases 0.000 description 1
• WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
• 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 230000000254 damaging effect Effects 0.000 description 1
• 230000003413 degradative effect Effects 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 238000000586 desensitisation Methods 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
• MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical class C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 description 1
• FAVAVMFXAKZTMV-UHFFFAOYSA-N dibutylboranyl trifluoromethanesulfonate Chemical compound CCCCB(CCCC)OS(=O)(=O)C(F)(F)F FAVAVMFXAKZTMV-UHFFFAOYSA-N 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 1
• UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 208000008576 dracunculiasis Diseases 0.000 description 1
• 238000002296 dynamic light scattering Methods 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 210000003162 effector t lymphocyte Anatomy 0.000 description 1
• 235000013601 eggs Nutrition 0.000 description 1
• 229920001971 elastomer Polymers 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 238000004945 emulsification Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 230000000369 enteropathogenic effect Effects 0.000 description 1
• 231100000249 enterotoxic Toxicity 0.000 description 1
• 230000002242 enterotoxic effect Effects 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 235000019325 ethyl cellulose Nutrition 0.000 description 1
• 229920001249 ethyl cellulose Polymers 0.000 description 1
• 125000004494 ethyl ester group Chemical group 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• 125000005469 ethylenyl group Chemical group 0.000 description 1
• 230000005713 exacerbation Effects 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 235000021323 fish oil Nutrition 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 235000019264 food flavour enhancer Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
• 150000002270 gangliosides Chemical class 0.000 description 1
• 229940124670 gardiquimod Drugs 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• 150000002307 glutamic acids Chemical class 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 239000004519 grease Substances 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 231100000869 headache Toxicity 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 244000000013 helminth Species 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 208000005252 hepatitis A Diseases 0.000 description 1
• 238000004896 high resolution mass spectrometry Methods 0.000 description 1
• 238000012766 histopathologic analysis Methods 0.000 description 1
• 238000000265 homogenisation Methods 0.000 description 1
• 201000009163 human granulocytic anaplasmosis Diseases 0.000 description 1
• 208000022340 human granulocytic ehrlichiosis Diseases 0.000 description 1
• 230000008348 humoral response Effects 0.000 description 1
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
• FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 description 1
• 229960002751 imiquimod Drugs 0.000 description 1
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
• 230000005965 immune activity Effects 0.000 description 1
• 230000008105 immune reaction Effects 0.000 description 1
• 230000008073 immune recognition Effects 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 229940072221 immunoglobulins Drugs 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 238000010324 immunological assay Methods 0.000 description 1
• 230000001024 immunotherapeutic effect Effects 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000001524 infective effect Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 239000002198 insoluble material Substances 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000007915 intraurethral administration Methods 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 230000002427 irreversible effect Effects 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 125000005468 isobutylenyl group Chemical group 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• 108010024383 kallikrein 4 Proteins 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 125000000468 ketone group Chemical group 0.000 description 1
• 201000006370 kidney failure Diseases 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 150000003893 lactate salts Chemical class 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 201000005296 lung carcinoma Diseases 0.000 description 1
• 201000003866 lung sarcoma Diseases 0.000 description 1
• 206010025135 lupus erythematosus Diseases 0.000 description 1
• 239000002932 luster Substances 0.000 description 1
• 101710130522 mRNA export factor Proteins 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 210000001806 memory b lymphocyte Anatomy 0.000 description 1
• 210000003071 memory t lymphocyte Anatomy 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 150000004702 methyl esters Chemical class 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• 239000012569 microbial contaminant Substances 0.000 description 1
• 239000003094 microcapsule Substances 0.000 description 1
• 239000003226 mitogen Substances 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 210000005087 mononuclear cell Anatomy 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 210000004498 neuroglial cell Anatomy 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
• 231100000344 non-irritating Toxicity 0.000 description 1
• 230000002126 nonhaemolytic effect Effects 0.000 description 1
• 239000000346 nonvolatile oil Substances 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 150000003833 nucleoside derivatives Chemical class 0.000 description 1
• 235000014571 nuts Nutrition 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 229940046166 oligodeoxynucleotide Drugs 0.000 description 1
• 229920001542 oligosaccharide Polymers 0.000 description 1
• 150000002482 oligosaccharides Chemical class 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 229940099789 ospa protein Drugs 0.000 description 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
• 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000000813 peptide hormone Substances 0.000 description 1
• 210000005259 peripheral blood Anatomy 0.000 description 1
• 239000011886 peripheral blood Substances 0.000 description 1
• 108010021711 pertactin Proteins 0.000 description 1
• 229940066842 petrolatum Drugs 0.000 description 1
• 235000019271 petrolatum Nutrition 0.000 description 1
• LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 description 1
• 150000004713 phosphodiesters Chemical class 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 101150106828 pmpD gene Proteins 0.000 description 1
• 229940124733 pneumococcal vaccine Drugs 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 229950008882 polysorbate Drugs 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 229910000027 potassium carbonate Inorganic materials 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• CAEWJEXPFKNBQL-UHFFFAOYSA-N prop-2-enyl carbonochloridate Chemical compound ClC(=O)OCC=C CAEWJEXPFKNBQL-UHFFFAOYSA-N 0.000 description 1
• 125000005470 propylenyl group Chemical group 0.000 description 1
• 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
• 150000003180 prostaglandins Chemical class 0.000 description 1
• 244000000040 protozoan parasite Species 0.000 description 1
• 230000005180 public health Effects 0.000 description 1
• 238000003908 quality control method Methods 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 239000003488 releasing hormone Substances 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 description 1
• 208000023504 respiratory system disease Diseases 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 239000008165 rice bran oil Substances 0.000 description 1
• 229910052707 ruthenium Inorganic materials 0.000 description 1
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
• 235000002020 sage Nutrition 0.000 description 1
• 238000007127 saponification reaction Methods 0.000 description 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 230000000405 serological effect Effects 0.000 description 1
• 238000009589 serological test Methods 0.000 description 1
• 239000010686 shark liver oil Substances 0.000 description 1
• 229940069764 shark liver oil Drugs 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 238000007390 skin biopsy Methods 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 108091029842 small nuclear ribonucleic acid Proteins 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 230000003595 spectral effect Effects 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 150000003432 sterols Chemical class 0.000 description 1
• 235000003702 sterols Nutrition 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 229940031626 subunit vaccine Drugs 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• KUNICNFETYAKKO-UHFFFAOYSA-N sulfuric acid;pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O KUNICNFETYAKKO-UHFFFAOYSA-N 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 208000032922 susceptibility to mycobacterium tuberculosis Diseases 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 229940118376 tetanus toxin Drugs 0.000 description 1
• TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
• 229940021747 therapeutic vaccine Drugs 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 108040006218 thyroid-stimulating hormone receptor activity proteins Proteins 0.000 description 1
• 102000015486 thyroid-stimulating hormone receptor activity proteins Human genes 0.000 description 1
• 230000003867 tiredness Effects 0.000 description 1
• 208000016255 tiredness Diseases 0.000 description 1
• 230000024664 tolerance induction Effects 0.000 description 1
• 239000003970 toll like receptor agonist Substances 0.000 description 1
• 229940044616 toll-like receptor 7 agonist Drugs 0.000 description 1
• REJLGAUYTKNVJM-SGXCCWNXSA-N tomatine Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@@]1(NC[C@@H](C)CC1)O5)C)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O REJLGAUYTKNVJM-SGXCCWNXSA-N 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 239000012049 topical pharmaceutical composition Substances 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 231100000440 toxicity profile Toxicity 0.000 description 1
• 238000006276 transfer reaction Methods 0.000 description 1
• 102000027257 transmembrane receptors Human genes 0.000 description 1
• 108091008578 transmembrane receptors Proteins 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• 229940093609 tricaprylin Drugs 0.000 description 1
• 229940096911 trichinella spiralis Drugs 0.000 description 1
• 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
• NQPHMXWPDCSHTE-UHFFFAOYSA-N trifluoromethanesulfonyl azide Chemical compound FC(F)(F)S(=O)(=O)N=[N+]=[N-] NQPHMXWPDCSHTE-UHFFFAOYSA-N 0.000 description 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
• FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
• VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
• 229960001005 tuberculin Drugs 0.000 description 1
• 229960002109 tuberculosis vaccine Drugs 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
• 230000002477 vacuolizing effect Effects 0.000 description 1
• 244000052613 viral pathogen Species 0.000 description 1
• 239000000277 virosome Substances 0.000 description 1
• 239000000304 virulence factor Substances 0.000 description 1
• 230000007923 virulence factor Effects 0.000 description 1
• 210000001835 viscera Anatomy 0.000 description 1
• 230000009278 visceral effect Effects 0.000 description 1
• 239000011709 vitamin E Substances 0.000 description 1
• 235000019165 vitamin E Nutrition 0.000 description 1
• 229940046009 vitamin E Drugs 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 229940051021 yellow-fever virus Drugs 0.000 description 1