ATE518874T1 - Synthetische lipid-a analogen und verwendungen davon - Google Patents

Synthetische lipid-a analogen und verwendungen davon

Info

Publication number
ATE518874T1
ATE518874T1 AT00980380T AT00980380T ATE518874T1 AT E518874 T1 ATE518874 T1 AT E518874T1 AT 00980380 T AT00980380 T AT 00980380T AT 00980380 T AT00980380 T AT 00980380T AT E518874 T1 ATE518874 T1 AT E518874T1
Authority
AT
Austria
Prior art keywords
lipid
synthetic
structures
novel
disaccharide
Prior art date
Application number
AT00980380T
Other languages
English (en)
Inventor
Zi-Hua Jiang
Mimi Bach
Damayanthi Yalamati
Rao Koganty
Michael Longenecker
Original Assignee
Oncothyreon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncothyreon Inc filed Critical Oncothyreon Inc
Application granted granted Critical
Publication of ATE518874T1 publication Critical patent/ATE518874T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
AT00980380T 1999-11-15 2000-11-15 Synthetische lipid-a analogen und verwendungen davon ATE518874T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16492899P 1999-11-15 1999-11-15
PCT/US2000/031281 WO2001036433A2 (en) 1999-11-15 2000-11-15 Synthetic lipid-a analogs and uses thereof

Publications (1)

Publication Number Publication Date
ATE518874T1 true ATE518874T1 (de) 2011-08-15

Family

ID=22596692

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00980380T ATE518874T1 (de) 1999-11-15 2000-11-15 Synthetische lipid-a analogen und verwendungen davon

Country Status (8)

Country Link
US (1) US7491707B1 (de)
EP (1) EP1232168B1 (de)
JP (1) JP2003514824A (de)
AT (1) ATE518874T1 (de)
AU (1) AU780577B2 (de)
CA (1) CA2396744C (de)
ES (1) ES2370262T3 (de)
WO (1) WO2001036433A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2424131T3 (es) 2001-03-27 2013-09-27 Oncothyreon Inc. Vacuna para modular respuestas inmunitarias entre T1 y T2
ATE529123T1 (de) * 2002-04-15 2011-11-15 Oncothyreon Inc Synthetische glykolipopeptide als impfstoffe
DE60331330D1 (de) 2002-05-09 2010-04-01 Oncothyreon Inc Lipid-a- und andere kohlenhydrat-liganden-analoga
AU2003242470A1 (en) * 2002-06-18 2003-12-31 Sankyo Company, Limited 1-carboxymethyl analogues of glucosyl lipid a
AU2002950657A0 (en) * 2002-08-08 2002-09-12 Alchemia Limited Derivatives of monosaccharides for drug discovery
AU2002951995A0 (en) 2002-10-11 2002-10-31 Alchemia Limited Classes of compounds that interact with gpcrs
US7960522B2 (en) * 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
JP4838706B2 (ja) * 2003-01-06 2011-12-14 コリクサ コーポレイション 所定のアミノアルキルグルコサミニドフォスフェート化合物及びそれらの使用
EP1547581A1 (de) * 2003-12-23 2005-06-29 Vectron Therapeutics AG Liposomaler Impstoff für die Behandlung von menschlichen hematologischen mlignen Erkrankungen
TWI395591B (zh) 2004-04-01 2013-05-11 Oncothyreon Inc 黏液性糖蛋白（ｍｕｃ-１）疫苗
ES2558131T3 (es) 2005-06-28 2016-02-02 Oncothyreon Inc. Método para el tratamiento de pacientes con una vacuna de glicoproteína mucinosa (MUC-1)
EP1803814A1 (de) 2005-12-27 2007-07-04 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Methode zur Verbesserung der Antikörperselektionskapazität in einer Phagen-Display-Bibliothek
EP3795173A1 (de) 2006-09-26 2021-03-24 Infectious Disease Research Institute Impfstoffzusammensetzung mit einem synthetischen adjuvans
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
WO2008059307A2 (en) * 2006-11-16 2008-05-22 Om Pharma Functionalized beta 1,6 glucosamine disaccharides and process for their preparation
EA020604B1 (ru) * 2008-12-17 2014-12-30 Онкотиреон, Инк. Композиция, содержащая липосомы малого размера, и способ ее получения
AU2010256461B2 (en) 2009-06-05 2016-03-17 Access To Advanced Health Institute Synthetic glucopyranosyl lipid adjuvants
CA2800911A1 (en) * 2010-06-11 2011-12-15 University Of Georgia Research Foundation, Inc. Immunogenic vaccine
EP2678005A4 (de) 2011-02-24 2015-06-10 Oncothyreon Inc Glycolipopeptid-impfstoff auf muc1-basis mit einem adjuvans
EP3632463A1 (de) 2011-04-08 2020-04-08 Immune Design Corp. Immunogene zusammensetzungen und verfahren zur verwendung der zusammensetzungen zur induzierung humoraler und zellulärer immunreaktionen
US20140328876A1 (en) 2011-11-18 2014-11-06 Variation Biotechnologies Inc. Synthetic derivatives of mpl and uses thereof
US9518078B2 (en) 2012-04-12 2016-12-13 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
US9241988B2 (en) 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
RS57420B1 (sr) 2012-05-16 2018-09-28 Immune Design Corp Vakcine za hsv-2
BR112015025709A2 (pt) 2013-04-18 2017-07-18 Immune Design Corp monoterapia com gla para uso em tratamento de câncer
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
WO2016109880A1 (en) 2015-01-06 2016-07-14 Immunovaccine Technologies Inc. Lipid a mimics, methods of preparation, and uses thereof
CN109125250B (zh) * 2018-08-30 2022-07-19 陕西中医药大学 一种小分子凝胶剂及制备方法和妇科用固-液互变型凝胶制剂
WO2021050778A1 (en) * 2019-09-10 2021-03-18 The Penn State Research Foundation Lipopolysaccharide molecules for enhancing immune responses
CN113214329A (zh) * 2020-01-21 2021-08-06 上海医药工业研究院 Lipid X及其中间体的制备方法、其中间体
JPWO2021261444A1 (de) 2020-06-22 2021-12-30

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5134230A (en) * 1988-03-02 1992-07-28 Daiichi Pharmaceutical Co., Ltd. 2-Deoxy-2-aminoglucopyranoside derivatives
ZA881430B (de) 1988-03-02 1988-10-28
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
WO1992015607A2 (en) * 1991-03-06 1992-09-17 G.D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
AU660325B2 (en) 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
DK0729473T3 (da) * 1993-11-17 2000-10-30 Deutsche Om Arzneimittel Gmbh Glucosamin-disaccharider, fremgangsmåde til deres fremstilling farmaceutisk sammensætning deraf og deres anvendelse
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
CA2189356A1 (en) 1994-05-02 1995-11-09 Ting Chi Wong Process for preparation of glycosides of tumor-associated carbohydrate antigens
US6887483B2 (en) * 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
EP0966480A2 (de) 1997-01-30 1999-12-29 The University Of Virginia Patent Foundation Cystein-reduzierte peptide, welche durch a3-limitierte zytotoxische lymphozyten erkannt werden, sowie anwendungen

Also Published As

Publication number Publication date
CA2396744A1 (en) 2001-05-25
AU780577B2 (en) 2005-04-07
JP2003514824A (ja) 2003-04-22
EP1232168A2 (de) 2002-08-21
ES2370262T3 (es) 2011-12-14
US7491707B1 (en) 2009-02-17
WO2001036433A2 (en) 2001-05-25
AU1764701A (en) 2001-05-30
CA2396744C (en) 2011-07-12
EP1232168B1 (de) 2011-08-03
WO2001036433A3 (en) 2002-05-10

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