DE69401204T2 - Gonadotropin enthaltende gefriergetrocknete troepfen - Google Patents

Gonadotropin enthaltende gefriergetrocknete troepfen

Info

Publication number
DE69401204T2
DE69401204T2 DE69401204T DE69401204T DE69401204T2 DE 69401204 T2 DE69401204 T2 DE 69401204T2 DE 69401204 T DE69401204 T DE 69401204T DE 69401204 T DE69401204 T DE 69401204T DE 69401204 T2 DE69401204 T2 DE 69401204T2
Authority
DE
Germany
Prior art keywords
gonadotropine
pct
dried drops
freezer dried
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69401204T
Other languages
English (en)
Other versions
DE69401204D1 (de
Inventor
Arnold Skrabanja
Herman Vromans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69401204D1 publication Critical patent/DE69401204D1/de
Publication of DE69401204T2 publication Critical patent/DE69401204T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
DE69401204T 1993-04-28 1994-04-25 Gonadotropin enthaltende gefriergetrocknete troepfen Expired - Lifetime DE69401204T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201215 1993-04-28
PCT/EP1994/001303 WO1994025005A1 (en) 1993-04-28 1994-04-25 Lyospheres comprising gonadotropin

Publications (2)

Publication Number Publication Date
DE69401204D1 DE69401204D1 (de) 1997-01-30
DE69401204T2 true DE69401204T2 (de) 1997-06-05

Family

ID=8213798

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69401204T Expired - Lifetime DE69401204T2 (de) 1993-04-28 1994-04-25 Gonadotropin enthaltende gefriergetrocknete troepfen

Country Status (16)

Country Link
US (1) US5656597A (de)
EP (1) EP0695171B1 (de)
JP (1) JPH08509483A (de)
KR (1) KR100334856B1 (de)
AT (1) ATE146360T1 (de)
AU (1) AU679986B2 (de)
CA (1) CA2150251C (de)
DE (1) DE69401204T2 (de)
DK (1) DK0695171T3 (de)
ES (1) ES2098140T3 (de)
FI (1) FI112324B (de)
GR (1) GR3022510T3 (de)
HK (1) HK1002017A1 (de)
NO (1) NO311168B1 (de)
NZ (1) NZ265956A (de)
WO (1) WO1994025005A1 (de)

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IL120202A (en) * 1996-03-07 2001-03-19 Akzo Nobel Nv Container with freeze-dried vaccine components
GB2329124B (en) * 1997-09-12 2002-05-08 Hiran Asoka Malinga Ratwatte Method of forming dose units of active agents
EP1658840A1 (de) * 1999-04-05 2006-05-24 Mannkind Corporation Verfahren zur Bildung von feinem Pulver
US6440463B1 (en) 1999-04-05 2002-08-27 Pharmaceutical Discovery Corporation Methods for fine powder formation
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US20040248784A1 (en) 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
TWI436789B (zh) 2008-01-21 2014-05-11 Intervet Int Bv 含有藥學化合物的顆粒之冷凍乾燥方法及含有此顆粒的藥學包
BRPI0909820A2 (pt) 2008-03-05 2015-08-11 Sanofi Pasteur Processo para estabilização de composição de vacina contra gripe, para estabilização de composição de vacina contendo adjuvante e para preparação de vacina, composições de vacina, kit de vacina e método de estocagem de uma matéria prima
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
EP2440184B1 (de) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazin-mikropartikel mit definierten spefiischen oberflächenbereichen
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (de) 2013-03-15 2022-07-13 MannKind Corporation Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2017066134A1 (en) * 2015-10-16 2017-04-20 Merck Sharp & Dohme Corp. Processes for preparing formulations for gastrointestinal-targeted therapies

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932943A (en) * 1970-08-14 1976-01-20 E. I. Du Pont De Nemours And Company Method of preparation of lyophilized biological products
EP0081913B1 (de) * 1981-12-11 1985-06-26 JOHN WYETH & BROTHER LIMITED Verfahren und Vorrichtung zum Gefrieren einer Flüssigkeit
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
DK0432232T3 (da) * 1989-05-01 1994-01-31 Alkermes Inc Fremgangsmåde til fremstilling af små partikler af biologisk aktive molekyler
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations

Also Published As

Publication number Publication date
NO954320D0 (no) 1995-10-27
EP0695171A1 (de) 1996-02-07
FI953442A0 (fi) 1995-07-14
NO954320L (no) 1995-10-27
AU679986B2 (en) 1997-07-17
FI112324B (fi) 2003-11-28
CA2150251C (en) 2005-02-22
US5656597A (en) 1997-08-12
KR950703934A (ko) 1995-11-17
FI953442A (fi) 1995-07-14
AU6648894A (en) 1994-11-21
JPH08509483A (ja) 1996-10-08
ES2098140T3 (es) 1997-04-16
ATE146360T1 (de) 1997-01-15
EP0695171B1 (de) 1996-12-18
DK0695171T3 (da) 1997-06-02
NZ265956A (en) 1996-09-25
NO311168B1 (no) 2001-10-22
GR3022510T3 (en) 1997-05-31
KR100334856B1 (ko) 2002-11-07
DE69401204D1 (de) 1997-01-30
HK1002017A1 (en) 1998-07-24
CA2150251A1 (en) 1994-11-10
WO1994025005A1 (en) 1994-11-10

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