HU9603269D0 - New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs - Google Patents

New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Info

Publication number
HU9603269D0
HU9603269D0 HU9603269A HU9603269A HU9603269D0 HU 9603269 D0 HU9603269 D0 HU 9603269D0 HU 9603269 A HU9603269 A HU 9603269A HU 9603269 A HU9603269 A HU 9603269A HU 9603269 D0 HU9603269 D0 HU 9603269D0
Authority
HU
Hungary
Prior art keywords
desoxy
chain
immunosuppressive drugs
branched
saturated
Prior art date
Application number
HU9603269A
Other languages
English (en)
Other versions
HU220336B (hu
HUT75340A (en
Inventor
Dieter Herrmann
Alfred Mertens
Hans-Georg Opitz
Harald Zilch
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of HU9603269D0 publication Critical patent/HU9603269D0/hu
Publication of HUT75340A publication Critical patent/HUT75340A/hu
Publication of HU220336B publication Critical patent/HU220336B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HU9603269A 1994-05-28 1995-05-23 Nukleozid-monofoszfátok új lipidészterei, eljárás előállításukra és alkalmazásuk immunszuppresszív gyógyszerekben HU220336B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Publications (3)

Publication Number Publication Date
HU9603269D0 true HU9603269D0 (en) 1997-01-28
HUT75340A HUT75340A (en) 1997-05-28
HU220336B HU220336B (hu) 2001-12-28

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9603269A HU220336B (hu) 1994-05-28 1995-05-23 Nukleozid-monofoszfátok új lipidészterei, eljárás előállításukra és alkalmazásuk immunszuppresszív gyógyszerekben

Country Status (27)

Country Link
US (1) US6025343A (hu)
EP (2) EP0763049B1 (hu)
JP (1) JP3802057B2 (hu)
KR (1) KR100279087B1 (hu)
CN (1) CN1168735C (hu)
AT (2) ATE236189T1 (hu)
AU (1) AU688516B2 (hu)
BR (1) BR9507785A (hu)
CA (1) CA2190983C (hu)
CZ (1) CZ291846B6 (hu)
DE (3) DE4418690A1 (hu)
DK (2) DK0763049T3 (hu)
ES (2) ES2199250T3 (hu)
FI (1) FI117673B (hu)
HU (1) HU220336B (hu)
IL (1) IL113865A (hu)
MX (1) MX9605809A (hu)
NO (1) NO308998B1 (hu)
NZ (1) NZ287434A (hu)
PL (1) PL185290B1 (hu)
PT (2) PT763049E (hu)
RU (1) RU2165429C2 (hu)
SK (1) SK284207B6 (hu)
TW (1) TW420686B (hu)
UA (1) UA45339C2 (hu)
WO (1) WO1995032984A1 (hu)
ZA (1) ZA954374B (hu)

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US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
WO2006066074A2 (en) 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
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CA2647391C (en) 2006-04-04 2015-12-29 The Regents Of The University Of California Kinase antagonists
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EP2175863B1 (en) 2007-07-09 2018-03-21 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
CN102124009B (zh) 2008-07-08 2014-07-23 因特利凯公司 激酶抑制剂及其使用方法
WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
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US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
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JP6027611B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
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US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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Also Published As

Publication number Publication date
RU2165429C2 (ru) 2001-04-20
NO965054D0 (no) 1996-11-27
HU220336B (hu) 2001-12-28
AU2615495A (en) 1995-12-21
EP0763049A1 (en) 1997-03-19
FI964727A (fi) 1996-11-27
DK0763049T3 (da) 2003-07-28
PT763049E (pt) 2003-08-29
PL317380A1 (en) 1997-04-01
ATE249472T1 (de) 2003-09-15
NO965054L (no) 1997-01-28
KR970703354A (ko) 1997-07-03
CZ347796A3 (en) 1997-04-16
EP1229040B8 (en) 2003-11-05
BR9507785A (pt) 1997-09-23
DE69530197T2 (de) 2004-01-29
ZA954374B (en) 1996-11-29
CZ291846B6 (cs) 2003-06-18
CN1154111A (zh) 1997-07-09
FI964727A0 (fi) 1996-11-27
JP3802057B2 (ja) 2006-07-26
EP1229040A2 (en) 2002-08-07
CA2190983A1 (en) 1995-12-07
DE4418690A1 (de) 1996-01-11
JPH10500964A (ja) 1998-01-27
EP1229040B1 (en) 2003-09-10
IL113865A (en) 2008-12-29
PT1229040E (pt) 2003-12-31
TW420686B (en) 2001-02-01
CN1168735C (zh) 2004-09-29
FI117673B (fi) 2007-01-15
PL185290B1 (pl) 2003-04-30
NZ287434A (en) 1998-01-26
NO308998B1 (no) 2000-11-27
MX9605809A (es) 1997-12-31
KR100279087B1 (ko) 2001-01-15
EP0763049B1 (en) 2003-04-02
SK151896A3 (en) 1997-06-04
DK1229040T3 (da) 2003-12-22
ATE236189T1 (de) 2003-04-15
EP1229040A3 (en) 2002-08-21
WO1995032984A8 (en) 2003-01-16
CA2190983C (en) 2006-08-15
ES2206429T3 (es) 2004-05-16
DE69531749T2 (de) 2004-07-29
UA45339C2 (uk) 2002-04-15
ES2199250T3 (es) 2004-02-16
AU688516B2 (en) 1998-03-12
IL113865A0 (en) 1995-08-31
US6025343A (en) 2000-02-15
SK284207B6 (en) 2004-11-03
HUT75340A (en) 1997-05-28
WO1995032984A1 (en) 1995-12-07
DE69530197D1 (de) 2003-05-08
DE69531749D1 (de) 2003-10-16

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