HRP20210979T1 - Konjugati pirolobenzodiazepin-protutijelo - Google Patents

Konjugati pirolobenzodiazepin-protutijelo Download PDF

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HRP20210979T1
HRP20210979T1 HRP20210979TT HRP20210979T HRP20210979T1 HR P20210979 T1 HRP20210979 T1 HR P20210979T1 HR P20210979T T HRP20210979T T HR P20210979TT HR P20210979 T HRP20210979 T HR P20210979T HR P20210979 T1 HRP20210979 T1 HR P20210979T1
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group
alkyl
image
methyl
saturated
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HRP20210979TT
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Patricius Hendrikus Cornelis VAN BERKEL
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Adc Therapeutics Sa
Medimmune Limited
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Priority claimed from GBGB1702031.4A external-priority patent/GB201702031D0/en
Priority claimed from GBGB1702029.8A external-priority patent/GB201702029D0/en
Priority claimed from GBGB1719906.8A external-priority patent/GB201719906D0/en
Application filed by Adc Therapeutics Sa, Medimmune Limited filed Critical Adc Therapeutics Sa
Publication of HRP20210979T1 publication Critical patent/HRP20210979T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (26)

1. Konjugat, naznačen time, da je predstavljen formulom (I): Ab – (DL)p (I) u kojoj: Ab je protutijelo koje se veže na AXL; DL je [image] gdje: X se bira iz skupine koja sadrži: jednostruku vezu, -CH2- i -C2H4-; n iznosi od 1 do 8; m iznosi 0 ili 1; R7 je ili metil ili fenil; kada postoji dvostruka veza koja se nalazi između C2 i C3, tada se R2 bira iz skupine koja se sastoji od: (ia) C5-10 arilne skupine, opcionalno supstituirane s jednim ili više supstituenata koji se biraju iz skupine koju čine: halogen, nitro, cijano, eter, karboksi, ester, C1-7 alkil, C3-7 heterociklil i bis-oksi-C1-3 alkilen; (ib) C1-5 zasićenog alifatskog alkila; (ic) C3-6 zasićenog cikloalkila; (id) [image] gdje se svaki od R21, R22 i R23 neovisno bira od H, C1-3 zasićenog alkila, C2-3 alkenila, C2-3 alkinila i ciklopropila, pri čemu ukupni broj ugljikovih atoma u R2 skupini nije veći od 5; (ie) [image] gdje jedan od R25a i R25b jest H, a drugi se bira od: fenila, dok je fenil opcionalno supstituiran sa skupinom odabranom od halogena, metila, metoksi; piridila; i tiofenila; i (if) [image] gdje se R24 bira od: H; C1-3 zasićenog alkila; C2-3 alkenila; C2-3 alkinila; ciklopropila; fenila, pri čemu je fenil opcionalno supstituiran sa skupinom odabranom od halogena, metila, metoksi; piridila; i tiofenila; kada postoji jednostruka veza koja se nalazi između C2 i C3, tada R2 jest [image] gdje se R26a i R26b neovisno biraju od H, F, C1-4 zasićenog alkila, C2-3 alkenila, dok su skupine alkila i alkenila opcionalno supstituirane sa skupinom odabranom od C1-4 alkil amido i C1-4 alkil estera; ili, kada jedan od R26a i R26b predstavlja H, tada se drugi bira od nitrila i C1-4 alkil estera; kada postoji dvostruka veza koja se nalazi između C2' i C3', tada se R12 bira iz skupine koja se sastoji od: (iia) C5-10 arilne skupine, opcionalno supstituirane s jednim ili više supstituenata odabranih iz skupine koja sadrži: halogen, nitro, cijano, eter, karboksi, ester, C1-7alkil, C3-7heterociklil i bis-oksi-C1-3 alkilen; (iib) C1-5 zasićenog alifatskog alkila; (iic) C3-6 zasićenog cikloalkila; (iid) [image] pri čemu se svaki od R31, R32 i R33 neovisno bira od H, C1-3 zasićenog alkila, C2-3 alkenila, C2-3 alkinila i ciklopropila, dok ukupni broj ugljikovih atoma u skupini R12 nije veći od 5; (iie) [image] gdje jedan od R35a i R35b jest H, a drugi se bira od: fenila, dok je fenil opcionalno supstituiran sa skupinom odabranom od halogena, metila, metoksi; piridila; i tiofenila; i (iif) [image] gdje se R34 bira od: H; C1-3 zasićenog alkila; C2-3 alkenila; C2-3 alkinila; ciklopropila; fenila, pri čemu je fenil opcionalno supstituiran sa skupinom odabranom od halogena, metila, metoksi; piridila; i tiofenila; kada postoji jednostruka veza koja se nalazi između C2' i C3', tada R12 jest [image] gdje se R36a i R36b neovisno biraju od H, F, C1-4 zasićenog alkila, C2-3 alkenila, dok su skupine alkila i alkenila opcionalno supstituirane sa skupinom odabranom od C1-4 alkil amido i C1-4 alkil estera; ili, kada jedan od R36a i R36b predstavlja H, tada se drugi bira od nitrila i C1-4 alkil estera; pri čemu se u (ia) i (iia), C1-7 alkil odnosi na monovalentni ostatak koji se dobiva putem odstranjivanja vodikovog atoma od ugljikovog atoma u ugljikovodičnom spoju koji ima od jednoga do sedam ugljikovih atoma, koji može biti alifatski ili aliciklički, te koji može biti zasićen ili nezasićen; i u (if) i (iif), C1-4 alkil se odnosi na monovalentni ostatak koji se dobiva putem odstranjivanja vodikovog atoma od ugljikovog atoma u ugljikovodičnom spoju koji ima od jednoga do četiri ugljikovih atoma, koji može biti alifatski ili aliciklički, te koji može biti zasićen ili nezasićen; i p iznosi od 1 do 8.
2. Konjugat prema patentnom zahtjevu 1, naznačen time, da X jest -CH2-.
3. Konjugat prema patentnim zahtjevima 1 ili 2, naznačen time, da n iznosi od 1 do 4.
4. Konjugat prema patentnom zahtjevu 3, naznačen time, da n iznosi 2.
5. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da postoji dvostruka veza između C2 i C3, i R2 jest C1-5 zasićena alifatska alkilna skupina.
6. Spoj prema patentnom zahtjevu 5, naznačen time, da R2 je metil, etil ili propil.
7. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da postoji dvostruka veza između C2 i C3, i R2 je: (a) fenil koji nosi jednu do tri supstituentske skupine, pri čemu se supstituenti mogu birati od metoksi, etoksi, fluoro, kloro, cijano, bis-oksi-metilena, metil-piperazinila, morfolino i metil-tiofenila; ili (b) ciklopropil; ili (c) skupina formule: [image] gdje ukupni broj ugljikovih atoma u skupini R2 nije veći od 3; ili (d) skupina: [image] ili (e) skupina formule: [image] gdje se R24 se bira od H i metila.
8. Spoj prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time, da postoji jednostruka veza između C2 i C3, R2 je: [image] i (a) oba R26a i R26b su H; ili (b) oba R26a i R26b su metil; ili (c) jedan od R26a i R26b je H, a drugi se bira od C1-4 zasićenog alkila, C2-3 alkenila, gdje su skupine alkila i alkenila opcionalno supstituirane.
9. Spoj prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time, da postoji dvostruka veza između C2' i C3', i R12 jest C1-5 zasićena alifatska alkilna skupina.
10. Spoj prema patentnom zahtjevu 9, naznačen time, da R12 je metil, etil ili propil.
11. Spoj prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time, da postoji dvostruka veza između C2' i C3', i R12 je: (a) fenil koji nosi jednu do tri supstituentske skupine, pri čemu se supstituenti mogu birati od metoksi, etoksi, fluoro, kloro, cijano, bis-oksi-metilena, metil-piperazinila, morfolino i metil-tiofenila; ili (b) ciklopropil; ili (c) skupina formule: [image] gdje ukupni broj ugljikovih atoma u skupini R12 nije veći od 3; ili (d) skupina: [image] ili (e) skupina formule: [image] gdje se R34 bira od H i metila.
12. Spoj prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time, da postoji jednostruka veza između C2 i C3, R2 je: [image] i (a) oba R36a i R36b su H; ili (b) oba R36a i R36b su metil; ili (c) jedan od R36a i R36b jest H, a drugi se bira od C1-4 zasićenog alkila, C2-3 alkenila, gdje su skupine alkila i alkenila opcionalno supstituirane.
13. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 12, naznačen time, da protutijelo sadrži VH domenu koja sadrži VH CDR3 s aminokiselinskim slijedom SEQ ID NO. 7, VH CDR2 s aminokiselinskim slijedom SEQ ID NO. 6, i VH CDR1 s aminokiselinskim slijedom SEQ ID NO. 5.
14. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 13, naznačen time, da protutijelo sadrži VH domenu koja ima slijed SEQ ID NO. 1.
15. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 14, naznačen time, da protutijelo sadrži VL domenu koja sadrži VL CDR3 s aminokiselinskim slijedom SEQ ID NO. 10, VL CDR2 s aminokiselinskim slijedom SEQ ID NO. 9, i VL CDR1 s aminokiselinskim slijedom SEQ ID NO. 8.
16. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 15, naznačen time, da protutijelo sadrži VL domenu koja ima slijed SEQ ID NO. 2.
17. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 16, naznačen time, da protutijelo sadrži teški lanac koji ima slijed SEQ ID NO. 3 ili SEQ ID NO: 24.
18. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 17, naznačen time, da protutijelo sadrži teški lanac koji ima slijed SEQ ID NO. 3, sparen s lakim lancem koji ima slijed SEQ ID NO: 4.
19. Pripravak, naznačen time, da sadrži mješavinu spojeva konjugata protutijelo-lijek kako je definirano u skladu s bilo kojim od patentnih zahtjeva 1 do 18, pri čemu prosječna opterećenost lijekom prema protutijelu u mješavini spojeva konjugata protutijelo-lijek, iznosi od 1 do 4.
20. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 18, naznačen time, da je za uporabu u liječenju.
21. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 18, naznačen time, da je za uporabu u liječenju proliferativne bolesti kod pojedinca.
22. Konjugat za uporabu prema patentnom zahtjevu 21, naznačen time, da bolest jest rak.
23. Konjugat za uporabu prema bilo kojem od patentnih zahtjeva 21 ili 22, gdje je bolest ili rak naznačen/a time, da je prisutna neoplazma koja sadrži i AXL+ve i AXL-ve stanice.
24. Konjugat prema bilo kojem od patentnih zahtjeva 1 do 18, naznačen time, da je za uporabu u postupku liječenja proliferativne bolesti, pri čemu navedeni postupak obuhvaća: (i) identifikaciju prisutnosti neoplazme, kod pojedinca,koja sadrži i AXL+ve i AXL-ve stanice; (ii) davanje pojedincu konjugata protutijelo-lijek.
25. Farmaceutski pripravak, naznačen time, da sadrži konjugat u skladu s bilo kojim od patentnih zahtjeva 1 do 18, i farmaceutski prihvatljiv razrjeđivač, nosač ili pomoćno sredstvo.
26. Farmaceutski pripravak prema patentnom zahtjevu 25, naznačen time, da nadalje sadrži terapijski učinkovitu količinu kemoterapeutskog sredstva.
HRP20210979TT 2017-02-08 2021-06-21 Konjugati pirolobenzodiazepin-protutijelo HRP20210979T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1702031.4A GB201702031D0 (en) 2017-02-08 2017-02-08 Pyrrolobenzodiazepine-antibody conjugates
GBGB1702029.8A GB201702029D0 (en) 2017-02-08 2017-02-08 Pyrrolobenzodiazepine-antibody conjugates
GBGB1719906.8A GB201719906D0 (en) 2017-11-30 2017-11-30 Pyrrolobenzodiazepine-antibody conjugates
EP18704956.4A EP3544636B1 (en) 2017-02-08 2018-02-08 Pyrrolobenzodiazepine-antibody conjugates
PCT/EP2018/053163 WO2018146189A1 (en) 2017-02-08 2018-02-08 Pyrrolobenzodiazepine-antibody conjugates

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EP (1) EP3544636B1 (hr)
JP (1) JP6671555B2 (hr)
KR (2) KR102181375B1 (hr)
CN (1) CN110267686B (hr)
AU (1) AU2018217926B2 (hr)
BR (1) BR112019016373B1 (hr)
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