HRP20031075B1 - Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram - Google Patents
Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopramInfo
- Publication number
- HRP20031075B1 HRP20031075B1 HR20031075A HRP20031075A HRP20031075B1 HR P20031075 B1 HRP20031075 B1 HR P20031075B1 HR 20031075 A HR20031075 A HR 20031075A HR P20031075 A HRP20031075 A HR P20031075A HR P20031075 B1 HRP20031075 B1 HR P20031075B1
- Authority
- HR
- Croatia
- Prior art keywords
- citalopram
- acid salt
- racemic
- optionally
- precipitate
- Prior art date
Links
- 229960001653 citalopram Drugs 0.000 title abstract 12
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 239000002244 precipitate Substances 0.000 abstract 5
- 239000012458 free base Substances 0.000 abstract 3
- 239000012452 mother liquor Substances 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100991 | 2001-06-25 | ||
| PCT/DK2002/000426 WO2003000672A1 (en) | 2001-06-25 | 2002-06-25 | Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20031075A2 HRP20031075A2 (en) | 2004-04-30 |
| HRP20031075B1 true HRP20031075B1 (en) | 2011-12-31 |
Family
ID=8160584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20031075A HRP20031075B1 (en) | 2001-06-25 | 2003-12-23 | Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US7112686B2 (ja) |
| EP (1) | EP1412341B1 (ja) |
| JP (2) | JP4377219B2 (ja) |
| KR (4) | KR20100052550A (ja) |
| CN (2) | CN101440079B (ja) |
| AR (2) | AR034612A1 (ja) |
| AT (1) | ATE284395T1 (ja) |
| BG (1) | BG66372B1 (ja) |
| BR (1) | BRPI0210574B8 (ja) |
| CA (2) | CA2450890C (ja) |
| CO (1) | CO5550420A2 (ja) |
| CZ (1) | CZ305034B6 (ja) |
| DE (1) | DE60202216T2 (ja) |
| DK (1) | DK1412341T3 (ja) |
| EA (1) | EA006446B1 (ja) |
| ES (1) | ES2233834T3 (ja) |
| HK (2) | HK1068627A1 (ja) |
| HR (1) | HRP20031075B1 (ja) |
| HU (1) | HU228476B1 (ja) |
| IL (1) | IL159229A0 (ja) |
| IS (1) | IS2426B (ja) |
| JO (1) | JO2389B1 (ja) |
| MA (1) | MA26260A1 (ja) |
| ME (2) | MEP1508A (ja) |
| MX (1) | MXPA03011770A (ja) |
| MY (1) | MY133471A (ja) |
| NO (2) | NO329873B1 (ja) |
| NZ (1) | NZ530104A (ja) |
| PE (1) | PE20030122A1 (ja) |
| PL (1) | PL366560A1 (ja) |
| PT (1) | PT1412341E (ja) |
| RS (1) | RS50673B (ja) |
| SI (1) | SI1412341T1 (ja) |
| SK (1) | SK287696B6 (ja) |
| TN (1) | TNSN02062A1 (ja) |
| TW (1) | TWI236473B (ja) |
| UA (1) | UA75147C2 (ja) |
| UY (2) | UY27356A1 (ja) |
| WO (1) | WO2003000672A1 (ja) |
| ZA (1) | ZA200309633B (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR040970A1 (es) * | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
| ES2385975T3 (es) * | 2002-12-23 | 2012-08-06 | H. Lundbeck A/S | Procedimiento para la preparación de citalopram diol racémico y/o S- O R-citalopram dioles y el uso de tales dioles para la preparación de citalopram racémico, R-citalopram y/o S-citalopram |
| AU2003291960B2 (en) | 2002-12-23 | 2009-11-19 | H. Lundbeck A/S | A process for the preparation of racemic citalopram diol and/or S- or R- citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
| CA2511142A1 (en) | 2002-12-23 | 2004-07-08 | H. Lundbeck A/S | Escitalopram hydrobromide and a method for the preparation thereof |
| WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| CN100569765C (zh) * | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| EP1732514A1 (en) * | 2004-03-05 | 2006-12-20 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| ES2285972T1 (es) * | 2004-08-23 | 2007-12-01 | Sun Pharmaceutical Industries Limited | Procedimiento de fabricacion de citalopram y enantiomeros. |
| EP1901714A2 (en) * | 2005-05-20 | 2008-03-26 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| TWI358407B (en) * | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| JP2009511606A (ja) | 2005-10-14 | 2009-03-19 | ハー・ルンドベック・アクチエゼルスカベット | エスシタロプラムおよびブプロピオンの低用量の併用を用いる中枢神経系障害の治療方法 |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| US8022232B2 (en) * | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| NZ570884A (en) | 2007-09-11 | 2010-03-26 | Lundbeck & Co As H | Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom |
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN101560199B (zh) * | 2008-04-16 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种依地普仑的制备方法 |
| TWI381813B (zh) | 2010-01-12 | 2013-01-11 | Taiwan Paiho Ltd | A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0347066A1 (en) * | 1988-06-14 | 1989-12-20 | H. Lundbeck A/S | New enantiomers and their isolation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| CA2291133C (en) * | 1999-10-25 | 2003-06-17 | H. Lundbeck A/S | Method for the preparation of citalopram |
-
2002
- 2002-06-21 AR ARP020102350A patent/AR034612A1/es active IP Right Grant
- 2002-06-23 JO JO200265A patent/JO2389B1/en active
- 2002-06-24 TN TNTNSN02062A patent/TNSN02062A1/en unknown
- 2002-06-24 PE PE2002000551A patent/PE20030122A1/es active IP Right Grant
- 2002-06-25 DE DE60202216T patent/DE60202216T2/de not_active Expired - Lifetime
- 2002-06-25 CA CA2450890A patent/CA2450890C/en not_active Expired - Fee Related
- 2002-06-25 TW TW091113845A patent/TWI236473B/zh not_active IP Right Cessation
- 2002-06-25 MY MYPI20022382A patent/MY133471A/en unknown
- 2002-06-25 EA EA200400082A patent/EA006446B1/ru not_active IP Right Cessation
- 2002-06-25 UA UA20031211986A patent/UA75147C2/uk unknown
- 2002-06-25 EP EP02742848A patent/EP1412341B1/en not_active Expired - Lifetime
- 2002-06-25 MA MA26713A patent/MA26260A1/fr unknown
- 2002-06-25 MX MXPA03011770A patent/MXPA03011770A/es active IP Right Grant
- 2002-06-25 BR BRPI0210574A patent/BRPI0210574B8/pt not_active IP Right Cessation
- 2002-06-25 JP JP2003507077A patent/JP4377219B2/ja not_active Expired - Lifetime
- 2002-06-25 ME MEP-15/08A patent/MEP1508A/xx unknown
- 2002-06-25 CZ CZ2004-131A patent/CZ305034B6/cs not_active IP Right Cessation
- 2002-06-25 RS YUP-1014/03A patent/RS50673B/sr unknown
- 2002-06-25 SI SI200230078T patent/SI1412341T1/xx unknown
- 2002-06-25 SK SK51-2004A patent/SK287696B6/sk unknown
- 2002-06-25 ME MEP-2008-15A patent/ME00027B/me unknown
- 2002-06-25 NZ NZ530104A patent/NZ530104A/en not_active IP Right Cessation
- 2002-06-25 US US10/482,000 patent/US7112686B2/en not_active Expired - Lifetime
- 2002-06-25 KR KR1020107006751A patent/KR20100052550A/ko not_active Application Discontinuation
- 2002-06-25 PT PT02742848T patent/PT1412341E/pt unknown
- 2002-06-25 AT AT02742848T patent/ATE284395T1/de active
- 2002-06-25 KR KR1020097004586A patent/KR100939945B1/ko active IP Right Grant
- 2002-06-25 KR KR1020037016853A patent/KR100902530B1/ko active IP Right Grant
- 2002-06-25 WO PCT/DK2002/000426 patent/WO2003000672A1/en active Application Filing
- 2002-06-25 PL PL02366560A patent/PL366560A1/xx not_active Application Discontinuation
- 2002-06-25 DK DK02742848T patent/DK1412341T3/da active
- 2002-06-25 IL IL15922902A patent/IL159229A0/xx active IP Right Grant
- 2002-06-25 ES ES02742848T patent/ES2233834T3/es not_active Expired - Lifetime
- 2002-06-25 CN CN2008102158851A patent/CN101440079B/zh not_active Expired - Lifetime
- 2002-06-25 CA CA2691149A patent/CA2691149C/en not_active Expired - Fee Related
- 2002-06-25 UY UY27356A patent/UY27356A1/es not_active IP Right Cessation
- 2002-06-25 HU HU0400293A patent/HU228476B1/hu unknown
- 2002-06-25 KR KR1020087026708A patent/KR20080100498A/ko active Application Filing
- 2002-06-25 CN CNB028126688A patent/CN100429208C/zh not_active Expired - Lifetime
-
2003
- 2003-12-08 IS IS7068A patent/IS2426B/is unknown
- 2003-12-11 ZA ZA2003/09633A patent/ZA200309633B/en unknown
- 2003-12-18 NO NO20035671A patent/NO329873B1/no not_active IP Right Cessation
- 2003-12-23 HR HR20031075A patent/HRP20031075B1/xx not_active IP Right Cessation
-
2004
- 2004-01-14 BG BG108532A patent/BG66372B1/bg unknown
- 2004-01-22 CO CO04004620A patent/CO5550420A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 HK HK05101034.1A patent/HK1068627A1/xx not_active IP Right Cessation
-
2009
- 2009-04-17 JP JP2009101188A patent/JP5064436B2/ja not_active Expired - Lifetime
- 2009-11-12 HK HK09110569.1A patent/HK1132729A1/xx not_active IP Right Cessation
-
2010
- 2010-10-13 NO NO20101420A patent/NO335106B1/no not_active IP Right Cessation
-
2011
- 2011-10-19 AR ARP110103869A patent/AR083483A2/es active IP Right Grant
-
2014
- 2014-11-21 UY UY0001035850A patent/UY35850A/es not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0347066A1 (en) * | 1988-06-14 | 1989-12-20 | H. Lundbeck A/S | New enantiomers and their isolation |
Also Published As
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