HK23494A - Substituted bicycle compounds - Google Patents

Substituted bicycle compounds Download PDF

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Publication number
HK23494A
HK23494A HK234/94A HK23494A HK23494A HK 23494 A HK23494 A HK 23494A HK 234/94 A HK234/94 A HK 234/94A HK 23494 A HK23494 A HK 23494A HK 23494 A HK23494 A HK 23494A
Authority
HK
Hong Kong
Prior art keywords
formula
compound
carboxy
alkyl
lower alkyl
Prior art date
Application number
HK234/94A
Other languages
German (de)
English (en)
French (fr)
Inventor
Leslie J. Dr. Browne
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK23494A publication Critical patent/HK23494A/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HK234/94A 1984-06-20 1994-03-17 Substituted bicycle compounds HK23494A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (1)

Publication Number Publication Date
HK23494A true HK23494A (en) 1994-03-25

Family

ID=24494112

Family Applications (1)

Application Number Title Priority Date Filing Date
HK234/94A HK23494A (en) 1984-06-20 1994-03-17 Substituted bicycle compounds

Country Status (31)

Country Link
US (1) US4617307A (forum.php)
EP (1) EP0165904B1 (forum.php)
JP (1) JPS6112688A (forum.php)
KR (1) KR900008566B1 (forum.php)
AT (1) ATE62415T1 (forum.php)
AU (1) AU589565B2 (forum.php)
BG (7) BG60262B2 (forum.php)
CA (1) CA1276633C (forum.php)
CS (1) CS268672B2 (forum.php)
CY (1) CY1750A (forum.php)
DD (1) DD237510A5 (forum.php)
DE (1) DE3582452D1 (forum.php)
DK (1) DK170302B1 (forum.php)
DZ (1) DZ799A1 (forum.php)
ES (6) ES8702406A1 (forum.php)
FI (1) FI80694C (forum.php)
GR (1) GR851487B (forum.php)
HK (1) HK23494A (forum.php)
HU (1) HU202529B (forum.php)
IE (1) IE58070B1 (forum.php)
IL (1) IL75546A (forum.php)
MA (1) MA20459A1 (forum.php)
MX (1) MX9203369A (forum.php)
NO (1) NO162467C (forum.php)
NZ (1) NZ212483A (forum.php)
PH (1) PH23390A (forum.php)
PL (6) PL145087B1 (forum.php)
PT (1) PT80661B (forum.php)
RO (1) RO92583A (forum.php)
SU (6) SU1433413A3 (forum.php)
ZA (1) ZA854615B (forum.php)

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BR112015019369A2 (pt) 2013-02-14 2017-07-18 Novartis Ag derivados de ácido bisfenil butanóico substituídos como inibidores de nep (endopeptidase neutra)
HK1218298A1 (zh) 2013-07-25 2017-02-10 Novartis Ag 用於治疗心力衰竭的环状多肽
AP2016009019A0 (en) 2013-07-25 2016-02-29 Novartis Ag Bioconjugates of synthetic apelin polypeptides
JP2018507187A (ja) 2015-01-23 2018-03-15 ノバルティス アーゲー 改善された半減期を有する合成アペリン脂肪酸コンジュゲート
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JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
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JP7130636B2 (ja) * 2016-10-27 2022-09-05 ダミアン ファーマ アーゲー アルドステロンシンターゼ阻害剤
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
SG11202010906XA (en) 2018-05-03 2020-12-30 Damian Pharma Ag R-fadrozole for use in the treatment of aldostonerism
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
WO2020110011A1 (en) 2018-11-27 2020-06-04 Novartis Ag Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
JP2022507958A (ja) 2018-11-27 2022-01-18 ノバルティス アーゲー 代謝障害の治療用のプロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）阻害薬としての環状四量体化合物
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物

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Also Published As

Publication number Publication date
EP0165904B1 (de) 1991-04-10
ES8801262A1 (es) 1987-12-16
FI80694C (fi) 1990-07-10
MX9203369A (es) 1992-09-01
PL145087B1 (en) 1988-08-31
DD237510A5 (de) 1986-07-16
BG60307B2 (en) 1994-07-25
IL75546A (en) 1990-01-18
NO162467B (no) 1989-09-25
FI80694B (fi) 1990-03-30
ES8800681A1 (es) 1987-11-16
ES8802049A1 (es) 1988-03-16
RO92583A (ro) 1987-11-30
BG60262B1 (bg) 1994-03-31
HUT37936A (en) 1986-03-28
IE851520L (en) 1985-12-20
EP0165904A2 (de) 1985-12-27
ATE62415T1 (de) 1991-04-15
BG60352B2 (bg) 1994-11-30
DE3582452D1 (de) 1991-05-16
CY1750A (en) 1994-06-03
DK170302B1 (da) 1995-07-31
ES544344A0 (es) 1987-01-01
ES555541A0 (es) 1987-11-16
ES8702406A1 (es) 1987-01-01
CS268672B2 (en) 1990-04-11
IL75546A0 (en) 1985-10-31
KR860000299A (ko) 1986-01-27
NO162467C (no) 1990-01-10
ZA854615B (en) 1986-02-26
ES8802155A1 (es) 1988-04-01
ES555538A0 (es) 1988-03-16
FI852399A0 (fi) 1985-06-17
PL145104B1 (en) 1988-08-31
CA1276633C (en) 1990-11-20
BG60305B2 (bg) 1994-07-25
PL145348B1 (en) 1988-09-30
NO852474L (no) 1985-12-23
ES555539A0 (es) 1988-04-01
PH23390A (en) 1989-07-26
JPS6112688A (ja) 1986-01-21
DZ799A1 (fr) 2004-09-13
BG60262B2 (en) 1994-03-31
MA20459A1 (fr) 1985-12-31
SU1436879A3 (ru) 1988-11-07
NZ212483A (en) 1988-10-28
DK277685A (da) 1985-12-21
CS444985A2 (en) 1989-07-12
BG60402B2 (bg) 1995-02-28
PT80661A (en) 1985-07-01
ES555542A0 (es) 1988-03-16
GR851487B (forum.php) 1985-11-25
ES555540A0 (es) 1987-12-16
SU1436880A3 (ru) 1988-11-07
PL254099A1 (en) 1986-09-09
AU4385785A (en) 1986-01-02
PT80661B (en) 1987-05-04
KR900008566B1 (ko) 1990-11-24
IE58070B1 (en) 1993-06-30
PL145105B1 (en) 1988-08-31
PL145103B1 (en) 1988-08-31
SU1482530A3 (ru) 1989-05-23
HU202529B (en) 1991-03-28
ES8802048A1 (es) 1988-03-16
BG60306B2 (bg) 1994-07-25
BG60353B2 (bg) 1994-11-30
US4617307A (en) 1986-10-14
DK277685D0 (da) 1985-06-19
PL145814B1 (en) 1988-11-30
AU589565B2 (en) 1989-10-19
JPH047746B2 (forum.php) 1992-02-12
SU1443802A3 (ru) 1988-12-07
FI852399L (fi) 1985-12-21
SU1436878A3 (ru) 1988-11-07
EP0165904A3 (en) 1987-09-09
SU1433413A3 (ru) 1988-10-23

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