DZ799A1 - Composés bicycliques substitués. - Google Patents

Composés bicycliques substitués.

Info

Publication number
DZ799A1
DZ799A1 DZ850130A DZ850130A DZ799A1 DZ 799 A1 DZ799 A1 DZ 799A1 DZ 850130 A DZ850130 A DZ 850130A DZ 850130 A DZ850130 A DZ 850130A DZ 799 A1 DZ799 A1 DZ 799A1
Authority
DZ
Algeria
Prior art keywords
alkyl
formula
compounds
substituted bicyclic
stereoisomers
Prior art date
Application number
DZ850130A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Application granted granted Critical
Publication of DZ799A1 publication Critical patent/DZ799A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DZ850130A 1984-06-20 1985-06-18 Composés bicycliques substitués. DZ799A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors

Publications (1)

Publication Number Publication Date
DZ799A1 true DZ799A1 (fr) 2004-09-13

Family

ID=24494112

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ850130A DZ799A1 (fr) 1984-06-20 1985-06-18 Composés bicycliques substitués.

Country Status (31)

Country Link
US (1) US4617307A (fr)
EP (1) EP0165904B1 (fr)
JP (1) JPS6112688A (fr)
KR (1) KR900008566B1 (fr)
AT (1) ATE62415T1 (fr)
AU (1) AU589565B2 (fr)
BG (7) BG60262B1 (fr)
CA (1) CA1276633C (fr)
CS (1) CS268672B2 (fr)
CY (1) CY1750A (fr)
DD (1) DD237510A5 (fr)
DE (1) DE3582452D1 (fr)
DK (1) DK170302B1 (fr)
DZ (1) DZ799A1 (fr)
ES (6) ES8702406A1 (fr)
FI (1) FI80694C (fr)
GR (1) GR851487B (fr)
HK (1) HK23494A (fr)
HU (1) HU202529B (fr)
IE (1) IE58070B1 (fr)
IL (1) IL75546A (fr)
MA (1) MA20459A1 (fr)
MX (1) MX9203369A (fr)
NO (1) NO162467C (fr)
NZ (1) NZ212483A (fr)
PH (1) PH23390A (fr)
PL (6) PL145814B1 (fr)
PT (1) PT80661B (fr)
RO (1) RO92583A (fr)
SU (6) SU1433413A3 (fr)
ZA (1) ZA854615B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US5428160A (en) * 1982-12-21 1995-06-27 Ciba-Geigy Corporation Substituted imidazo[5-a]pyridine derviatives and other substituted bicyclic derivatives
GB8510541D0 (en) * 1985-04-25 1985-05-30 Wyeth John & Brother Ltd Heterocyclic compounds
US5171858A (en) * 1985-06-05 1992-12-15 Schering A.G. Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4797411A (en) * 1986-07-18 1989-01-10 Farmitalia Carlo Erba S.P.A. Cycloalkyl-substituted 4-pyridyl derivatives and use as aromatase inhibitors
GB8820730D0 (en) * 1988-09-02 1988-10-05 Erba Carlo Spa Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
US5057521A (en) * 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
CA2026792A1 (fr) * 1989-11-01 1991-05-02 Michael N. Greco Derives de substitution (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl) et (5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-5-yl) du 1h-benzotriazole
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
EP0514015A1 (fr) * 1991-04-19 1992-11-19 Merck & Co. Inc. Contrôle de la différentiation du sexe chez le poisson
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
JPH05176659A (ja) * 1991-04-26 1993-07-20 Merck & Co Inc 家禽における雌性表現型を転換するために抗ミュラー管ホルモンを単独またはアロマターゼ阻害剤と組合せて使用する方法
WO1995028156A1 (fr) * 1994-04-14 1995-10-26 Sepracor, Inc. Traitement de maladies provoquees par les ×strogenes au moyen de (-)-fadrozole
EP0684235A1 (fr) * 1994-05-27 1995-11-29 Mochida Pharmaceutical Co., Ltd. Dérivés d'azolylméthyl-phényle présentant une activé inhibitant l'aromatase
DE4432106A1 (de) * 1994-09-09 1996-03-14 Hoechst Ag Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
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EP1749006A2 (fr) * 2004-05-28 2007-02-07 Speedel Experimenta AG Composes organiques
JP2008500997A (ja) * 2004-05-28 2008-01-17 シュペーデル・エクスペリメンタ・アーゲー アロマターゼ阻害剤としての二環式の窒素含有複素環
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AU2007267793A1 (en) * 2006-05-26 2007-12-06 Novartis Ag Aldosterone synthase and/or 11beta-hydroxylase inhibitors
PL2049517T3 (pl) 2006-07-20 2014-06-30 Novartis Ag Pochodne amino-piperydyny jako inhibitory CETP
BRPI0715938A2 (pt) * 2006-08-25 2014-05-20 Novartis Ag Derivados de imidazol fundidos para o tratamento de distúrbios mediados por aldosterona sintase e/ou 11-beta-hidroxilase e/ou aromatase
EP2120938A4 (fr) * 2006-12-20 2010-12-08 Merck Sharp & Dohme Analogues de l'imidazopyridine en tant que modulateurs du récepteur de cb2, utilisables pour le traitement de la douleur et des maladies respiratoires et non respiratoires
PT2207775E (pt) 2007-11-05 2012-05-11 Novartis Ag Derivados de 4-benzilamino-1-carboxiacil-piperidina como inibidores de cetp úteis para o tratamento de doenças tais como hiperlipidemia ou arteriosclerose
ES2425776T3 (es) 2007-12-03 2013-10-17 Novartis Ag Derivados 1,2-disustituidos de 4-bencilamino-pirrolidina como inhibidores CETP útiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis
EP2095819A1 (fr) * 2008-02-28 2009-09-02 Maastricht University Dérivés de N-benzyle imidazole et leur utilisation comme inhibiteurs de l'aldosterone synthase
KR20120041702A (ko) 2009-05-28 2012-05-02 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체
KR101442897B1 (ko) 2009-05-28 2014-09-23 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
TWI518073B (zh) * 2011-06-14 2016-01-21 美國禮來大藥廠 醛固酮合成酶抑制劑
ES2683350T3 (es) 2011-07-08 2018-09-26 Novartis Ag Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos
BR112014017260A8 (pt) 2012-01-17 2017-07-04 Novartis Ag formas e sais de um inibidor de di-hidropirrolo[1,2-c]imidazolil aldosterona sintase ou aromatase
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
PT2956464T (pt) 2013-02-14 2018-07-04 Novartis Ag Derivados de ácido bisfenil butanóico fosfónico substituído como inibidores de nep (endopeptidase neutra
AU2014293386B2 (en) 2013-07-25 2016-11-17 Novartis Ag Cyclic polypeptides for the treatment of heart failure
EP3024492A2 (fr) 2013-07-25 2016-06-01 Novartis AG Bioconjugués de polypeptides d'apeline synthétiques
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
RS61908B1 (sr) * 2015-01-29 2021-06-30 Recordati Ag Postupak za proizvodnju kondenzovanih imidazolo derivata
GB201511790D0 (en) * 2015-07-06 2015-08-19 Iomet Pharma Ltd Pharmaceutical compound
JP2016074729A (ja) * 2015-12-31 2016-05-12 国立大学法人 千葉大学 イミダゾリウム塩及びそれを用いた不斉合成触媒並びにイミダゾリウム塩の製造方法
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
WO2018078049A1 (fr) 2016-10-27 2018-05-03 Damian Pharma Ag Inhibiteur de l'aldostérone synthase
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
AU2019262310A1 (en) 2018-05-03 2020-11-12 Damian Pharma Ag R-fadrozole for use in the treatment of aldostonerism
EP3887363A1 (fr) 2018-11-27 2021-10-06 Novartis AG Composés pentamères cycliques servant d'inhibiteurs de proprotéine convertase subtilisine/kexine de type 9 (pcsk9) pour le traitement d'un trouble métabolique
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
EP3887388A1 (fr) 2018-11-27 2021-10-06 Novartis AG Peptides cycliques servant d'inhibiteurs de proprotéine convertase subtilisine/kexine de type 9 (pcsk9) pour le traitement de troubles métaboliques
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物

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FR2449689A1 (fr) * 1979-02-20 1980-09-19 Logeais Labor Jacques Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
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CA1250844A (fr) * 1981-06-22 1989-03-07 Neville Ford Derives de substitution de ¬1,5-a|pyridines; methode de preparation; compositions pharmaceutiques renfermant ces derives et leur utilisation comme medicaments
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US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors

Also Published As

Publication number Publication date
CS268672B2 (en) 1990-04-11
AU589565B2 (en) 1989-10-19
ES8802048A1 (es) 1988-03-16
PL145103B1 (en) 1988-08-31
JPH047746B2 (fr) 1992-02-12
ES8800681A1 (es) 1987-11-16
MX9203369A (es) 1992-09-01
BG60402B2 (bg) 1995-02-28
IE851520L (en) 1985-12-20
KR860000299A (ko) 1986-01-27
ES8801262A1 (es) 1987-12-16
BG60262B2 (en) 1994-03-31
EP0165904A2 (fr) 1985-12-27
FI852399A0 (fi) 1985-06-17
SU1433413A3 (ru) 1988-10-23
DK277685A (da) 1985-12-21
PT80661A (en) 1985-07-01
BG60262B1 (bg) 1994-03-31
ES555539A0 (es) 1988-04-01
ES544344A0 (es) 1987-01-01
PH23390A (en) 1989-07-26
BG60307B2 (en) 1994-05-27
SU1436878A3 (ru) 1988-11-07
SU1443802A3 (ru) 1988-12-07
ES8802155A1 (es) 1988-04-01
ES555542A0 (es) 1988-03-16
GR851487B (fr) 1985-11-25
DK170302B1 (da) 1995-07-31
ATE62415T1 (de) 1991-04-15
MA20459A1 (fr) 1985-12-31
PL145814B1 (en) 1988-11-30
FI80694B (fi) 1990-03-30
HUT37936A (en) 1986-03-28
AU4385785A (en) 1986-01-02
HU202529B (en) 1991-03-28
ES555540A0 (es) 1987-12-16
DE3582452D1 (de) 1991-05-16
NO162467B (no) 1989-09-25
PT80661B (en) 1987-05-04
IE58070B1 (en) 1993-06-30
BG60306B2 (bg) 1994-05-27
ES555538A0 (es) 1988-03-16
EP0165904B1 (fr) 1991-04-10
SU1436879A3 (ru) 1988-11-07
NZ212483A (en) 1988-10-28
PL145087B1 (en) 1988-08-31
ES8802049A1 (es) 1988-03-16
JPS6112688A (ja) 1986-01-21
HK23494A (en) 1994-03-25
PL254099A1 (en) 1986-09-09
RO92583A (fr) 1987-11-30
PL145105B1 (en) 1988-08-31
IL75546A0 (en) 1985-10-31
CS444985A2 (en) 1989-07-12
DK277685D0 (da) 1985-06-19
ES555541A0 (es) 1987-11-16
ES8702406A1 (es) 1987-01-01
EP0165904A3 (en) 1987-09-09
ZA854615B (en) 1986-02-26
FI852399L (fi) 1985-12-21
BG60352B2 (bg) 1994-08-15
US4617307A (en) 1986-10-14
SU1436880A3 (ru) 1988-11-07
NO162467C (no) 1990-01-10
KR900008566B1 (ko) 1990-11-24
IL75546A (en) 1990-01-18
NO852474L (no) 1985-12-23
PL145104B1 (en) 1988-08-31
CA1276633C (fr) 1990-11-20
DD237510A5 (de) 1986-07-16
BG60402B1 (bg) 1995-02-28
BG60305B2 (bg) 1994-05-27
FI80694C (fi) 1990-07-10
BG60353B2 (bg) 1994-08-15
CY1750A (en) 1994-06-03
SU1482530A3 (ru) 1989-05-23
PL145348B1 (en) 1988-09-30

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