HK1047597B - 促紅細胞生成素與聚乙二醇的偶聯物 - Google Patents

促紅細胞生成素與聚乙二醇的偶聯物

Info

Publication number
HK1047597B
HK1047597B HK02109179.2A HK02109179A HK1047597B HK 1047597 B HK1047597 B HK 1047597B HK 02109179 A HK02109179 A HK 02109179A HK 1047597 B HK1047597 B HK 1047597B
Authority
HK
Hong Kong
Prior art keywords
polyethylenglycol
erythropoietin conjugates
erythropoietin
conjugates
Prior art date
Application number
HK02109179.2A
Other languages
English (en)
Other versions
HK1047597A1 (en
Inventor
約瑟夫‧布爾格
貝恩德‧希爾格
漢斯-彼得‧約澤爾
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1047597A1 publication Critical patent/HK1047597A1/xx
Publication of HK1047597B publication Critical patent/HK1047597B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK02109179.2A 1999-07-02 2002-12-18 促紅細胞生成素與聚乙二醇的偶聯物 HK1047597B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14224399P 1999-07-02 1999-07-02
US14745299P 1999-08-05 1999-08-05
US15145499P 1999-08-30 1999-08-30
PCT/EP2000/006009 WO2001002017A2 (en) 1999-07-02 2000-06-28 Erythropoietin conjugates with polyethylenglycol

Publications (2)

Publication Number Publication Date
HK1047597A1 HK1047597A1 (en) 2003-02-28
HK1047597B true HK1047597B (zh) 2005-08-12

Family

ID=27385779

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02109179.2A HK1047597B (zh) 1999-07-02 2002-12-18 促紅細胞生成素與聚乙二醇的偶聯物

Country Status (33)

Country Link
US (1) US6340742B1 (zh)
EP (1) EP1196443B1 (zh)
JP (1) JP4190184B2 (zh)
KR (1) KR100510624B1 (zh)
CN (1) CN1194014C (zh)
AR (1) AR024879A1 (zh)
AT (1) ATE267840T1 (zh)
AU (1) AU768452B2 (zh)
BR (1) BRPI0012138B8 (zh)
CA (1) CA2378533C (zh)
CO (1) CO5180621A1 (zh)
CZ (1) CZ301833B6 (zh)
DE (1) DE60011087T2 (zh)
DK (1) DK1196443T3 (zh)
ES (1) ES2220501T3 (zh)
GC (1) GC0000196A (zh)
HK (1) HK1047597B (zh)
HR (1) HRP20010966B1 (zh)
HU (1) HU228478B1 (zh)
IL (2) IL146956A0 (zh)
JO (1) JO2291B1 (zh)
MA (1) MA26806A1 (zh)
MX (1) MXPA01012974A (zh)
MY (1) MY126776A (zh)
NO (1) NO20016304L (zh)
NZ (1) NZ516170A (zh)
PE (1) PE20010288A1 (zh)
PL (1) PL201754B1 (zh)
PT (1) PT1196443E (zh)
RS (1) RS50117B (zh)
TR (1) TR200103782T2 (zh)
TW (1) TWI266637B (zh)
WO (1) WO2001002017A2 (zh)

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