AU2002222740A1 - Fusion protein having the enhanced in vivo activity of erythropoietin - Google Patents

Fusion protein having the enhanced in vivo activity of erythropoietin

Info

Publication number
AU2002222740A1
AU2002222740A1 AU2002222740A AU2274002A AU2002222740A1 AU 2002222740 A1 AU2002222740 A1 AU 2002222740A1 AU 2002222740 A AU2002222740 A AU 2002222740A AU 2274002 A AU2274002 A AU 2274002A AU 2002222740 A1 AU2002222740 A1 AU 2002222740A1
Authority
AU
Australia
Prior art keywords
fusion protein
erythropoietin
enhanced
vivo activity
carboxy terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002222740A
Inventor
Bo-Sup Chung
Byung-Jhip Ha
Ki-Wan Kim
Dong-Eok Lee
Myung-Suk Oh
Ji-Sook Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ Corp
Original Assignee
CJ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020010072713A external-priority patent/KR101229995B1/en
Application filed by CJ Corp filed Critical CJ Corp
Publication of AU2002222740A1 publication Critical patent/AU2002222740A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a fusion protein in which a carboxy terminal of human erythropoietin (EPO) is fused with a carboxy terminal peptide fragment of beta subunit of human chorionic gonadotropin (HCG), to DNA encoding the fusion protein, and to a method for preparation of the fusion protein. The fusion protein has the enhanced in vivo activity of erythropoietin. <IMAGE>
AU2002222740A 2000-12-11 2001-12-10 Fusion protein having the enhanced in vivo activity of erythropoietin Abandoned AU2002222740A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20000075230 2000-12-11
KR0075230 2000-12-11
KR0172713 2001-11-21
KR1020010072713A KR101229995B1 (en) 2000-12-11 2001-11-21 Fusion protein having the enhanced in vivo activity of erythropoietin
PCT/KR2001/002137 WO2002048194A1 (en) 2000-12-11 2001-12-10 Fusion protein having the enhanced in vivo activity of erythropoietin

Publications (1)

Publication Number Publication Date
AU2002222740A1 true AU2002222740A1 (en) 2002-06-24

Family

ID=36178279

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002222740A Abandoned AU2002222740A1 (en) 2000-12-11 2001-12-10 Fusion protein having the enhanced in vivo activity of erythropoietin

Country Status (6)

Country Link
EP (1) EP1342730B1 (en)
JP (1) JP3946638B2 (en)
AT (1) ATE320449T1 (en)
AU (1) AU2002222740A1 (en)
DE (1) DE60117919T2 (en)
WO (1) WO2002048194A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100467751B1 (en) * 2001-12-03 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo erythropoietin activity
CA2485365A1 (en) * 2002-05-13 2003-11-20 Modigenetech Ltd. Ctp-extended erythropoietin
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2007092252A2 (en) 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
CA2720628A1 (en) 2007-07-26 2009-01-29 Novagen Holding Corporation Fusion proteins having mutated immunoglobulin hinge region
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
BR112014025951A2 (en) 2012-04-19 2017-07-11 Opko Biologics Ltd long-acting oxyntomodulin variants and production methods
CN112661863A (en) 2012-11-20 2021-04-16 奥普科生物制品有限公司 Method for increasing the hydrodynamic volume of a polypeptide by attachment to a gonadotrophin carboxy terminal peptide
CN103864913A (en) 2012-12-18 2014-06-18 联亚生技开发股份有限公司 Recombinant protein
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
EP3310347B1 (en) 2015-06-19 2021-08-04 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
KR20240006077A (en) 2016-07-11 2024-01-12 옵코 바이오로직스 리미티드 Long-acting coagulation factor vii and methods of producing same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3045539B2 (en) * 1989-02-21 2000-05-29 ワシントン ユニバーシティ Modified reproductive hormone
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
WO1993011244A1 (en) * 1991-11-29 1993-06-10 Weyerhaeuser Company Cyclic di-guanylate metabolic enzymes
DE69422169D1 (en) * 1993-04-20 2000-01-20 Univ St Louis MODIFIED PROTEINS AND PEPTIDES CONTAINING PHARMACEUTICAL AGENTS
IL110669A (en) * 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
JO2291B1 (en) * 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives

Also Published As

Publication number Publication date
JP3946638B2 (en) 2007-07-18
DE60117919D1 (en) 2006-05-11
EP1342730B1 (en) 2006-03-15
EP1342730A1 (en) 2003-09-10
EP1342730A4 (en) 2004-06-23
ATE320449T1 (en) 2006-04-15
DE60117919T2 (en) 2006-12-14
JP2004515246A (en) 2004-05-27
WO2002048194A1 (en) 2002-06-20

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