AR024879A1 - Derivados de eritropoyetina - Google Patents

Derivados de eritropoyetina

Info

Publication number
AR024879A1
AR024879A1 ARP000103319A ARP000103319A AR024879A1 AR 024879 A1 AR024879 A1 AR 024879A1 AR P000103319 A ARP000103319 A AR P000103319A AR P000103319 A ARP000103319 A AR P000103319A AR 024879 A1 AR024879 A1 AR 024879A1
Authority
AR
Argentina
Prior art keywords
kilodaltons
erythropoietin
glycoprotein
ethylene glycol
poly
Prior art date
Application number
ARP000103319A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR024879A1 publication Critical patent/AR024879A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se revelan conjugado de la glucoproteína eritropoyetina, dichos conjugados comprende una glocuproteína eritropoyetina que presenta al menos un grupo aminolibre, que presenta una actividad biologica in vivo con la que consigue que las células de lamé dula osea incrementen la produccion de reticulocitos y globulosrojos y que se selecciona del grupo de la eritropoyetina humana y análogos de la misma, que presentan la estructura primaria de la eritropoyetina humana modificada mediante la adicionde e ntre 1 y 6 sitios de glucosilacion o mediante la nueva disposicion de al menos un sitio de glucosilacion; dichaglucoproteína se encuentra unida de forma covalente a de uno a tres grupos alcoxi-inferior poli(etilen glicol), cada grupopoli(etilen glic ol) se encuentraunido covalentemente a la glucoproteína mediante un conector con la formula -C(O)-X-S-Y-, con el C(O) del conector formando un enlace amida con uno de dichosgrupos amino, en donde X e Y son tal como se han definidoen la descripcion y reivindicaciones, el valor medio del peso molecular de cada porcion de poli(etilen glicol) se encuentra entre alrededor de 20 kilodaltons y alrededor de 40 kilodaltons, y el peso molecular del conjugado se encuentra entrealrededor de51 kilodaltons y alrededor de 175 kilodaltons.
ARP000103319A 1999-07-02 2000-06-29 Derivados de eritropoyetina AR024879A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14224399P 1999-07-02 1999-07-02
US14745299P 1999-08-05 1999-08-05
US15145499P 1999-08-30 1999-08-30

Publications (1)

Publication Number Publication Date
AR024879A1 true AR024879A1 (es) 2002-10-30

Family

ID=27385779

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103319A AR024879A1 (es) 1999-07-02 2000-06-29 Derivados de eritropoyetina

Country Status (33)

Country Link
US (1) US6340742B1 (es)
EP (1) EP1196443B1 (es)
JP (1) JP4190184B2 (es)
KR (1) KR100510624B1 (es)
CN (1) CN1194014C (es)
AR (1) AR024879A1 (es)
AT (1) ATE267840T1 (es)
AU (1) AU768452B2 (es)
BR (1) BRPI0012138B8 (es)
CA (1) CA2378533C (es)
CO (1) CO5180621A1 (es)
CZ (1) CZ301833B6 (es)
DE (1) DE60011087T2 (es)
DK (1) DK1196443T3 (es)
ES (1) ES2220501T3 (es)
GC (1) GC0000196A (es)
HK (1) HK1047597B (es)
HR (1) HRP20010966B1 (es)
HU (1) HU228478B1 (es)
IL (2) IL146956A0 (es)
JO (1) JO2291B1 (es)
MA (1) MA26806A1 (es)
MX (1) MXPA01012974A (es)
MY (1) MY126776A (es)
NO (1) NO20016304L (es)
NZ (1) NZ516170A (es)
PE (1) PE20010288A1 (es)
PL (1) PL201754B1 (es)
PT (1) PT1196443E (es)
RS (1) RS50117B (es)
TR (1) TR200103782T2 (es)
TW (1) TWI266637B (es)
WO (1) WO2001002017A2 (es)

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