AU2002233230A1 - Erythropoietin conjugates - Google Patents
Erythropoietin conjugatesInfo
- Publication number
- AU2002233230A1 AU2002233230A1 AU2002233230A AU2002233230A AU2002233230A1 AU 2002233230 A1 AU2002233230 A1 AU 2002233230A1 AU 2002233230 A AU2002233230 A AU 2002233230A AU 2002233230 A AU2002233230 A AU 2002233230A AU 2002233230 A1 AU2002233230 A1 AU 2002233230A1
- Authority
- AU
- Australia
- Prior art keywords
- erythropoietin conjugates
- erythropoietin
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003951 Erythropoietin Human genes 0.000 title 1
- 108090000394 Erythropoietin Proteins 0.000 title 1
- 229940105423 erythropoietin Drugs 0.000 title 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00127891.0 | 2000-12-20 | ||
EP00127891 | 2000-12-20 | ||
PCT/EP2001/014434 WO2002049673A2 (en) | 2000-12-20 | 2001-12-08 | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002233230A1 true AU2002233230A1 (en) | 2002-09-05 |
AU2002233230B2 AU2002233230B2 (en) | 2007-02-01 |
Family
ID=8170728
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002233230A Ceased AU2002233230B2 (en) | 2000-12-20 | 2001-12-08 | Erythropoietin conjugates |
AU3323002A Pending AU3323002A (en) | 2000-12-20 | 2001-12-08 | Erythropoietin conjugates |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU3323002A Pending AU3323002A (en) | 2000-12-20 | 2001-12-08 | Erythropoietin conjugates |
Country Status (11)
Country | Link |
---|---|
US (1) | US7128913B2 (en) |
JP (2) | JP4656814B2 (en) |
KR (1) | KR100645843B1 (en) |
CN (1) | CN100528235C (en) |
AR (1) | AR035407A1 (en) |
AU (2) | AU2002233230B2 (en) |
BR (1) | BR0116381A (en) |
CA (1) | CA2431964C (en) |
ES (1) | ES2361824T3 (en) |
MX (1) | MXPA03005406A (en) |
ZA (1) | ZA200304647B (en) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998041226A1 (en) * | 1997-03-18 | 1998-09-24 | Roche Diagnostics Gmbh | Pharmaceutical combined preparations containing erythropoietin and iron preparations |
US7304150B1 (en) * | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
ATE291436T2 (en) | 2000-05-15 | 2005-04-15 | Hoffmann La Roche | LIQUID MEDICINAL PREPARATION CONTAINING AN ERYTHROPOIETIN DERIVATIVE |
CA2431964C (en) * | 2000-12-20 | 2013-09-10 | F. Hoffmann-La Roche Ag | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
CA2437342C (en) * | 2001-02-01 | 2013-08-06 | F. Hoffmann-La Roche Ag | Method for producing recombinant trypsin |
EP1234583A1 (en) * | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
DE60336555D1 (en) | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | PEGYLATED GLYCO FORMS OF FACTOR VII |
US7459435B2 (en) * | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
NZ519011A (en) * | 2002-09-01 | 2005-01-28 | Univ Waikato | Reaction process |
US7459436B2 (en) * | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
KR20060003862A (en) | 2003-03-14 | 2006-01-11 | 네오스 테크놀로지스, 인크. | Branched water-soluble polymers and their eonjugates |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
MXPA05010773A (en) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods. |
EP1624847B1 (en) | 2003-05-09 | 2012-01-04 | BioGeneriX AG | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
WO2004101611A2 (en) * | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Peptides that bind to the erythropoietin receptor |
EP1626983B8 (en) * | 2003-05-12 | 2010-12-22 | Affymax, Inc. | Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof |
PT1629007E (en) * | 2003-05-12 | 2009-05-06 | Affymax Inc | Novel peptides that bind to the erythropoietin receptor |
CA2525399A1 (en) | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based co mpounds |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
AU2004293103C1 (en) * | 2003-11-24 | 2010-12-02 | Ratiopharm Gmbh | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
BRPI0506741A (en) | 2004-01-08 | 2007-05-15 | Neose Technologies Inc | glycosylation of peptides linked to the |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
JP5948627B2 (en) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | Fibroblast growth factor (FGF) remodeling and carbohydrate pegylation |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
CA2587382A1 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
EP1848461A2 (en) * | 2005-02-16 | 2007-10-31 | Nektar Therapeutics Al, Corporation | Conjugates of an epo moiety and a polymer |
US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
JP5216580B2 (en) * | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー/エス | Glycopegylated factor IX |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
KR20170027868A (en) * | 2005-08-05 | 2017-03-10 | 아라임 파마슈티칼즈, 인크. | Tissue protective peptides and uses thereof |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20080171696A1 (en) * | 2005-10-21 | 2008-07-17 | Avigenics, Inc. | Pharmacodynamically enhanced therapeutic proteins |
US20070092486A1 (en) * | 2005-10-21 | 2007-04-26 | Avigenics, Inc. | Glycolated and glycosylated poultry derived therapeutic proteins |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
CN101516388B (en) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | Glycosylation of peptides via O-linked glycosylation sequences |
CN103169984B (en) | 2006-07-25 | 2016-08-03 | 利普生技术有限公司 | N-terminal is either polysialylated |
GB0615067D0 (en) * | 2006-07-28 | 2006-09-06 | Ttp Communications Ltd | Reconfigurable signal processing scheme |
ES2529234T3 (en) * | 2006-08-04 | 2015-02-18 | Prolong Pharmaceuticals, LLC | Modified erythropoietin |
EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Methods for the purification of polypeptide conjugates |
US20080083154A1 (en) * | 2006-10-05 | 2008-04-10 | Timothy M Gregory | Bait retention fish hook |
WO2008057537A2 (en) * | 2006-11-08 | 2008-05-15 | Maine Medical Center Research | System and method for identifying erythropoietin-responsive genes |
TW201627320A (en) * | 2007-02-02 | 2016-08-01 | 艾瑟勒朗法瑪公司 | Variants derived from ActRIIB and uses therefor |
RS52845B (en) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
JP5591691B2 (en) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | Compositions and methods for making biologically active fusion proteins |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
US7968811B2 (en) * | 2007-06-29 | 2011-06-28 | Harley-Davidson Motor Company Group, Inc. | Integrated ignition and key switch |
AR067536A1 (en) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | METHOD FOR OBTAINING A MONO-PEGILATED ERYTHROPOYETIN IN A SUBSTANTIALLY HOMOGENOUS FORM |
CL2008002053A1 (en) * | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Method for the purification of a monopeglated erythropoietin (epompeg) which consists of providing a solution containing mono, poly and non-peglated erythropoietin and passing it through two steps of cation exchange chromatography and a method to produce epo mpeg that includes a purification method. |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
EP2669313B1 (en) | 2008-01-11 | 2016-03-23 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
US8101706B2 (en) * | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
EP2257311B1 (en) | 2008-02-27 | 2014-04-16 | Novo Nordisk A/S | Conjugated factor viii molecules |
WO2015032973A1 (en) * | 2013-09-09 | 2015-03-12 | Lek Pharmaceuticals D.D. | Erythropoietin compositions for oral administration |
US10188739B2 (en) | 2014-02-27 | 2019-01-29 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
AU2016324119B2 (en) | 2015-09-18 | 2019-11-14 | Himuka AM Australia Pty Ltd. | Long-acting adrenomedullin derivative |
US20200179524A1 (en) | 2017-04-25 | 2020-06-11 | Lipoxen Technologies Limited | Methods of treating multiple myeloma cancers expressing high levels of epo-receptor using psa-epo |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR850004274A (en) | 1983-12-13 | 1985-07-11 | 원본미기재 | Method for preparing erythropoietin |
NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
US4677195A (en) | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
DE3785086T2 (en) | 1986-06-04 | 1993-07-08 | Agency Ind Science Techn | PREPARATION FOR CELL CULTURE AND THEIR USE. |
EP0318487B1 (en) | 1986-08-04 | 1993-10-13 | The University Of New South Wales | Serum free tissue culture medium containing polymeric cell-protective agent |
US4954437A (en) | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
EP0343635B1 (en) | 1988-05-25 | 1994-08-24 | Teijin Limited | Process for continuously culturing adherent animal cells |
FR2646438B1 (en) | 1989-03-20 | 2007-11-02 | Pasteur Institut | A METHOD FOR SPECIFIC REPLACEMENT OF A COPY OF A GENE PRESENT IN THE RECEIVER GENOME BY INTEGRATION OF A GENE DIFFERENT FROM THAT OR INTEGRATION |
DK0747485T3 (en) | 1989-11-06 | 1999-08-16 | Cell Genesys Inc | Preparation of proteins using homologous recombination |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
DE4115722A1 (en) | 1991-05-14 | 1992-11-19 | Boehringer Mannheim Gmbh | SERUM-FREE MEDIUM FOR CULTIVATING SUGAR CELLS |
US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
ATE225801T1 (en) | 1992-07-13 | 2002-10-15 | Bionebraska Inc | METHOD FOR MODIFYING RECOMBINANT POLYPEPTIDES |
NZ250375A (en) | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
IL110669A (en) * | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
JPH07165789A (en) * | 1993-12-15 | 1995-06-27 | Toray Res Center:Kk | Method for separating amino-terminal peptide of protein |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
CA2204726A1 (en) | 1994-11-09 | 1996-12-27 | Robin E. Offord | Functionalized polymers for site-specific attachment |
IL118201A (en) | 1995-05-11 | 2004-12-15 | Roche Diagnostics Gmbh | Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
DE19535571A1 (en) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Combined pharmaceutical preparations and their use for the treatment of hemodialysis patients |
TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
KR20000029673A (en) | 1996-08-02 | 2000-05-25 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
EP0921817B1 (en) | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
EP0885613A1 (en) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Use of modified hemoglobins for treatment of anemias and erythropoietin and modified hemoglobin containing combined preparations |
GB9716790D0 (en) * | 1997-08-07 | 1997-10-15 | Creative Peptides Sweden Ab | Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof |
DE19734293A1 (en) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Use of pharmaceutical combination preparations containing erythropoietin and iron preparations for the treatment of rheumatic diseases |
EP1135493A2 (en) * | 1998-11-30 | 2001-09-26 | Eli Lilly And Company | Erythropoietic compounds |
JP2002534119A (en) * | 1999-01-14 | 2002-10-15 | ボルダー バイオテクノロジー, インコーポレイテッド | Method for producing a protein having a free cysteine residue |
PE20010288A1 (en) | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | ERYTHROPOYETIN DERIVATIVES |
CZ299516B6 (en) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof |
ATE291436T2 (en) | 2000-05-15 | 2005-04-15 | Hoffmann La Roche | LIQUID MEDICINAL PREPARATION CONTAINING AN ERYTHROPOIETIN DERIVATIVE |
CA2431964C (en) * | 2000-12-20 | 2013-09-10 | F. Hoffmann-La Roche Ag | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
-
2001
- 2001-12-08 CA CA2431964A patent/CA2431964C/en not_active Expired - Lifetime
- 2001-12-08 JP JP2002551010A patent/JP4656814B2/en not_active Expired - Lifetime
- 2001-12-08 MX MXPA03005406A patent/MXPA03005406A/en active IP Right Grant
- 2001-12-08 CN CNB018206093A patent/CN100528235C/en not_active Expired - Lifetime
- 2001-12-08 BR BR0116381-7A patent/BR0116381A/en not_active IP Right Cessation
- 2001-12-08 KR KR1020037008299A patent/KR100645843B1/en not_active IP Right Cessation
- 2001-12-08 AU AU2002233230A patent/AU2002233230B2/en not_active Ceased
- 2001-12-08 AU AU3323002A patent/AU3323002A/en active Pending
- 2001-12-08 ES ES01984811T patent/ES2361824T3/en not_active Expired - Lifetime
- 2001-12-11 US US10/014,363 patent/US7128913B2/en not_active Expired - Lifetime
- 2001-12-18 AR ARP010105862A patent/AR035407A1/en unknown
-
2003
- 2003-06-13 ZA ZA200304647A patent/ZA200304647B/en unknown
-
2007
- 2007-09-18 JP JP2007241171A patent/JP4563434B2/en not_active Expired - Lifetime
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