HK1010993A1 - Needleless injector - Google Patents

Needleless injector

Info

Publication number
HK1010993A1
HK1010993A1 HK98111869A HK98111869A HK1010993A1 HK 1010993 A1 HK1010993 A1 HK 1010993A1 HK 98111869 A HK98111869 A HK 98111869A HK 98111869 A HK98111869 A HK 98111869A HK 1010993 A1 HK1010993 A1 HK 1010993A1
Authority
HK
Hong Kong
Prior art keywords
pct
injector
piston
outlet orifice
cam
Prior art date
Application number
HK98111869A
Other languages
English (en)
Inventor
Terence Edward Weston
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of HK1010993A1 publication Critical patent/HK1010993A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G7/00—Botany in general
    • A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
HK98111869A 1991-08-23 1998-11-09 Needleless injector HK1010993A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118204A GB9118204D0 (en) 1991-08-23 1991-08-23 Needle-less injector
PCT/GB1992/001539 WO1993003779A1 (fr) 1991-08-23 1992-08-21 Injecteur sans aiguille

Publications (1)

Publication Number Publication Date
HK1010993A1 true HK1010993A1 (en) 1999-07-02

Family

ID=10700421

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98111869A HK1010993A1 (en) 1991-08-23 1998-11-09 Needleless injector

Country Status (15)

Country Link
US (1) US5480381A (fr)
EP (1) EP0599940B1 (fr)
JP (2) JP3257794B2 (fr)
KR (1) KR100233339B1 (fr)
AT (1) ATE161427T1 (fr)
AU (1) AU2444592A (fr)
BR (1) BR9206407A (fr)
CA (1) CA2116341C (fr)
DE (1) DE69223793T2 (fr)
ES (1) ES2110513T3 (fr)
GB (1) GB9118204D0 (fr)
HK (1) HK1010993A1 (fr)
NO (1) NO307817B1 (fr)
RU (1) RU2129445C1 (fr)
WO (1) WO1993003779A1 (fr)

Families Citing this family (429)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US5569190A (en) * 1987-06-08 1996-10-29 D'antonio; Nicholas F. Hypodermic fluid dispenser
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
ATE254939T1 (de) * 1993-07-31 2003-12-15 Aradigm Corp Nadelloser injektor
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
DE29507987U1 (de) * 1995-05-15 1996-09-19 Ferton Holding, Delemont Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit
US5730723A (en) * 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6223786B1 (en) 1998-11-14 2001-05-01 Pen Jet Corporation Apparatus and method for mixing medication and filling an ampule of a needle-less injector
US6080130A (en) * 1998-11-14 2000-06-27 Castellano; Thomas P. Gas power source for a needle-less injector
US5697917A (en) 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5800388A (en) 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5722953A (en) 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5921967A (en) 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5865795A (en) 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
GB9607549D0 (en) * 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
JP3624543B2 (ja) * 1996-05-02 2005-03-02 東ソー株式会社 免疫反応試薬及びその製造方法
BR9710025A (pt) 1996-07-01 1999-08-10 Pharmacia & Upjohn Ab Dispositivo de distribuição de preparação processo para operar o mesmo sistema de recipientes de medicamento receipiente do tipo de cartucho de seringa sistema de marcação de leitura por máquina e dispositivo para análise de um objeto
FR2751228B1 (fr) * 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
AU4705797A (en) * 1996-09-26 1998-04-17 Akzo Nobel N.V. Needle-less injector
AU4391497A (en) 1996-09-27 1998-04-17 Weston Medical Limited Needleless injector accessory
US5875976A (en) 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US5911703A (en) * 1997-05-22 1999-06-15 Avant Drug Delivery Systems, Inc. Two-stage fluid medicament jet injector
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6156008A (en) * 1998-05-04 2000-12-05 Castellano; Thomas P. Device for avoiding subdermal hematomas from an injection
WO2000006227A1 (fr) * 1998-07-27 2000-02-10 Medi-Ject Corporation Mecanisme de chargement pour ensemble injecteur medical
EP1102606B1 (fr) 1998-07-27 2006-10-11 Antares Pharma, Inc. Sonde d'aide a l'injection pour ensemble injecteur medical
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
WO2000064514A1 (fr) * 1999-04-22 2000-11-02 Gilbert Garitano Dispositif sans aiguille pour maquillages permanents et tatouages
WO2000067825A1 (fr) * 1999-05-07 2000-11-16 Microheart, Inc. Appareil et procede d"administration d"agents therapeutiques et diagnostiques
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
ATE342089T1 (de) 1999-06-02 2006-11-15 Boston Scient Ltd Arzneimittelabgabevorrichtungen
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
WO2001051109A1 (fr) * 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Dispositif d"injection
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
DE10010123A1 (de) 2000-03-03 2001-09-20 Boehringer Ingelheim Int Nadelloser Injektor in Miniaturausführung
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US7150409B2 (en) * 2000-11-30 2006-12-19 Biovalve Technologies, Inc. Injection systems
US6758837B2 (en) 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
US20040071734A1 (en) 2001-02-23 2004-04-15 Nathalie Garcon Novel vaccine
CA2440983A1 (fr) 2001-03-14 2002-09-26 Penjet Corporation Systemes et procedes d'extraction de gaz dissous dans des liquides
ZA200200808B (en) * 2001-03-22 2002-08-12 Roche Diagnostics Gmbh Needleless hypodermic injection system, application device and medication cartridge therefor.
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
WO2002096311A1 (fr) * 2001-05-30 2002-12-05 Tomoyuki Takahashi Systeme d'epilation au laser sur avec mecanisme de protraction -retraction
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
WO2003002069A2 (fr) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Distribution intradermique de vaccins et d'agents therapeutiques geniques via une microcannule
US8061006B2 (en) 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
US6669664B2 (en) 2001-09-07 2003-12-30 Avant Drug Delivery Systems, Inc. Vacuum control cycle for jet injector
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US6939323B2 (en) 2001-10-26 2005-09-06 Massachusetts Institute Of Technology Needleless injector
CA2371466C (fr) * 2002-02-12 2010-02-09 Medical International Technology (Mit) Inc. Injecteur sans aiguille
ES2368040T3 (es) * 2002-06-10 2011-11-11 Intervet International Bv Inyector sin aguja.
EP1531889A1 (fr) 2002-08-26 2005-05-25 PenJet Corporation Dispositif d'injection sans aiguille a fluide degaze
CA2497815C (fr) 2002-09-06 2013-06-11 Massachusetts Institute Of Technology Mesure de proprietes d'un element anatomique
DE10252917A1 (de) * 2002-11-12 2004-05-27 Lothar Bode Druckinjektions-Handgerät zum Einbringen von Substanzen unter Druck eines gasförmigen oder flüssigen Druckmittels in eine zu behandelnde Hautstelle
US6939319B1 (en) * 2002-11-20 2005-09-06 Conrad Anstead Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
JP2006507061A (ja) * 2002-11-25 2006-03-02 テクファーマ・ライセンシング・アクチェンゲゼルシャフト リセット可能な解放安全装置を有する自動注射装置
CA2526720C (fr) 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Molecule support recombinee pour l'expression, l'administration et la purification de polypeptides cibles
WO2005034949A1 (fr) * 2003-09-09 2005-04-21 University Of Florida Derives de desferrithiocine et leur utilisation en tant que chelateurs du fer
KR20060120153A (ko) * 2003-11-27 2006-11-24 노보 노르디스크 에이/에스 분사 전달 장치를 위한 충격 챔버
WO2005070482A1 (fr) * 2004-01-26 2005-08-04 Novo Nordisk A/S Chambre a impulsions pour dispositif de distribution de jets
EP2514458B1 (fr) * 2004-06-09 2022-12-21 Mark Anderson and Associates, Incorporated Système d'injection hypodermique
NZ553776A (en) 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
WO2006058426A1 (fr) 2004-12-01 2006-06-08 Wlt Distributors Inc. Injecteur sans aiguille
JP5364110B2 (ja) * 2005-01-07 2013-12-11 柴田科学株式会社 透過光量測定装置及び相対吸光度測定装置、並びにこれらの測定方法
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
CA2601022C (fr) 2005-03-23 2023-03-07 Glaxosmithkline Biologicals S.A. Utilisation d'un virus de la grippe et d'un adjuvant de type emulsion huile dans l'eau pour induire une cellule t cd-4 et/ou ameliorer la reponse de la cellule a memoire b
ES2614086T3 (es) 2005-04-04 2017-05-29 University Of Florida Research Foundation, Inc. Análogos de poliéter de desferritiocina
EP1919504B1 (fr) * 2005-08-03 2013-10-16 iBio, Inc. Anticorps diriges contre l'antigene protecteur de bacillus anthracis
US8591457B2 (en) * 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
ES2437581T3 (es) 2005-11-17 2014-01-13 Zogenix, Inc. Suministro de formulaciones viscosas por inyección sin aguja
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007070682A2 (fr) * 2005-12-15 2007-06-21 Massachusetts Institute Of Technology Systeme de criblage de particules
EP3020411A1 (fr) 2005-12-22 2016-05-18 GlaxoSmithKline Biologicals s.a. Vaccin
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2637209A1 (fr) * 2006-01-17 2007-07-26 Zogenix, Inc. Administration sans aiguille de dose unique de medicaments antithrombotiques
US20070264130A1 (en) * 2006-01-27 2007-11-15 Phluid, Inc. Infusion Pumps and Methods for Use
JP2009526526A (ja) * 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
BRPI0707779B8 (pt) * 2006-02-13 2021-05-25 Fraunhofer Usa Inc antígeno isolado, composição de vacina e método para produção de uma proteína antígeno
WO2008048344A2 (fr) * 2006-02-13 2008-04-24 Fraunhofer Usa, Inc. Antigènes de bacillus anthracis, compositions pour vaccins et procédés connexes
CA2644694C (fr) * 2006-03-10 2014-05-13 Sangeeta N. Bhatia Conjugues a auto-assemblage declenche et nanosystemes
CA2681668C (fr) 2006-03-23 2014-04-01 Michael S. Singer Compositions comprenant des analogues de la prostaglandine f2-alpha et procedes pour reduire la graisse corporelle
EP1998802A2 (fr) 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Composition immunogène
JP2009534309A (ja) 2006-03-31 2009-09-24 マサチューセッツ インスティテュート オブ テクノロジー 治療剤の標的化送達のためのシステム
US20090325944A1 (en) * 2006-04-12 2009-12-31 Suzanne Walker Kahne Methods and Compositions for Modulating Glycosylation
US20090105685A1 (en) * 2006-04-21 2009-04-23 Novo Nordisk A/S Two Stage Jet Injection Device
JP5630998B2 (ja) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
AU2007256780B2 (en) 2006-06-02 2013-08-29 President And Fellows Of Harvard College Protein surface remodeling
WO2007150030A2 (fr) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Synthèse microfluidique de nanoparticules organiques
ES2469568T3 (es) 2006-07-17 2014-06-18 Glaxosmithkline Biologicals S.A. Vacuna contra la gripe
US9115358B2 (en) * 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
JP2010501074A (ja) * 2006-08-14 2010-01-14 マサチューセッツ・インスティテュート・オブ・テクノロジー グリカンのデータマイニングシステム
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
KR20090051246A (ko) 2006-09-01 2009-05-21 메사추세츠 인스티튜트 오브 테크놀로지 자동 장입 성능을 갖는 무침 주사기 장치
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP2433648A3 (fr) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccin comprenant une émulsion adjuvante huile en l'eau
CA2664619C (fr) 2006-10-12 2012-12-11 Glaxosmithkline Biologicals S.A. Compositions immunogenes contenant un adjuvant d'emulsion d'huile dans l'eau renfermant une quantite reduite de squalene, de tocol et un agent emulsifiant
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
CA2671447A1 (fr) 2006-12-01 2008-06-12 Anterios, Inc. Nanoparticules a entites amphiphiles
AU2007333225B2 (en) * 2006-12-08 2014-06-12 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
RU2506256C2 (ru) 2006-12-26 2014-02-10 Лантеус Медикал Имэджинг, Инк. Лиганды для визуализации иннервации сердца
CA2677045C (fr) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Peptides p53 stabilises et utilisations de ceux-ci
WO2008098165A2 (fr) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Bioréacteur oscillant pour la culture de cellules
US7744563B2 (en) * 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
AU2008229472B2 (en) 2007-03-15 2013-03-14 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
WO2008124634A1 (fr) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Micelles inverses encapsulées par un polymère
WO2008124632A1 (fr) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Nanoparticules assistées par des composés amphiphiles pour délivrance ciblée
BRPI0810865A2 (pt) * 2007-04-28 2017-05-09 Fraunhofer Usa Inc antígenos de tripanossoma, composições vacinais, e métodos relacionados
MX2009013118A (es) * 2007-06-14 2010-03-04 Crucell Switzerland Ag Vacuna intradermica contra la influenza.
WO2008156676A1 (fr) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Procédés et compositions de détection et de modulation de o-glycosylation
PT2167121E (pt) 2007-06-26 2015-12-02 Glaxosmithkline Biolog Sa Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae
CA2692933C (fr) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Antigenes yersinia pestis, compositions de vaccins, et methodes associees
WO2009026397A2 (fr) * 2007-08-20 2009-02-26 Fraunhofer Usa, Inc. Vaccins antigrippaux prophylactiques et thérapeutiques, antigènes, compositions et procédés
EP2205074A4 (fr) * 2007-10-04 2013-07-31 Harvard College Analogues de la moénomycine, procédés de synthèse et utilisations de ceux-ci
AU2008314647B2 (en) 2007-10-12 2013-03-21 Massachusetts Institute Of Technology Vaccine nanotechnology
KR20100111275A (ko) * 2008-01-03 2010-10-14 메사츄세츠 인스티튜트 어브 테크놀로지 유인 인플루엔자 치료제
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8986253B2 (en) * 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
JP5637982B2 (ja) * 2008-04-09 2014-12-10 インフィニティー ファーマシューティカルズ， インコーポレイテッド 脂肪酸アミド加水分解酵素の阻害剤
PT2271360E (pt) 2008-04-16 2015-12-07 Glaxosmithkline Biolog Sa Vacina
CA2725601A1 (fr) * 2008-04-28 2009-11-05 President And Fellows Of Harvard College Proteines fortement chargees utilisees pour la penetration cellulaire
EP2756756B1 (fr) * 2008-04-28 2016-01-06 Zogenix, Inc. Compositions inédites destinées au traitement de la migraine
WO2009143188A2 (fr) * 2008-05-19 2009-11-26 Diperna Paul M Réservoir à pompe jetable et procédés associés
KR100888831B1 (ko) 2008-06-02 2009-03-19 (주)클래시스 무바늘 분출 주사장치
BRPI0914630A2 (pt) 2008-06-26 2019-09-24 Anterios Inc liberação dérmica
US8680020B2 (en) 2008-07-15 2014-03-25 Academia Sinica Glycan arrays on PTFE-like aluminum coated glass slides and related methods
US20100075926A1 (en) * 2008-07-23 2010-03-25 Li-Huei Tsai Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
US20110144306A1 (en) * 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
US8408421B2 (en) * 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (fr) * 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Dispositif de mesure de la concentration d'un soluté et procédés associés
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) * 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
WO2010057197A1 (fr) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Compositions de vaccins contre le cancer et leurs méthodes d’utilisation
EP2376619A4 (fr) 2008-12-15 2012-07-04 Greenlight Biosciences Inc Procédés de commande de flux dans des voies métaboliques
WO2010074760A1 (fr) * 2008-12-22 2010-07-01 Greenlight Biosciences Compositions et procédés pour la production d'un composé
GB0900930D0 (en) * 2009-01-20 2009-03-04 Future Injection Technologies Ltd Injection device
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
CA2753214C (fr) 2009-02-27 2017-07-25 Tandem Diabetes Care, Inc. Procedes et dispositifs pour la determination d'un volume de reservoir d'ecoulement
US8546564B2 (en) 2009-04-07 2013-10-01 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
JP2012525146A (ja) 2009-04-28 2012-10-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 細胞透過のための過剰に荷電されたタンパク質
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
JP2012528858A (ja) 2009-06-01 2012-11-15 プレジデント アンド フェロウズ オブ ハーバード カレッジ Ｏ−ＧｌｃＮＡｃ転移酵素阻害剤およびその使用
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
EP2932994B1 (fr) 2009-07-30 2017-11-08 Tandem Diabetes Care, Inc. Nouveau joint torique, mécanisme de distribution et système de pompe de perfusion portable qui lui sont associés
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
WO2011028716A1 (fr) * 2009-09-01 2011-03-10 Massachusetts Institute Of Technology Procédé d'identification à système non linéaire pour tester l'efficacité de produits de soins de la peau
WO2011028719A2 (fr) 2009-09-01 2011-03-10 Massachusetts Institute Of Technology Techniques d'identification de systèmes non linéaires et dispositifs pour découvrir des propriétés de tissu dynamiques et statiques
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
WO2011041391A1 (fr) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Anticorps dirigés contre l'hémagglutinine du virus de la grippe, compositions, et procédés associés
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US20120003601A1 (en) 2009-12-15 2012-01-05 Massachusetts Institute Of Technology Jet Injector Use In Oral Evaluation
AU2010343102B2 (en) 2009-12-29 2016-03-24 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
CN102178990B (zh) * 2010-01-08 2013-10-09 江苏丞宇米特医疗科技有限公司 无针注射器
CA2787940C (fr) 2010-01-27 2020-01-07 Massachusetts Institute Of Technology Agents polypeptidiques techniques pour la neutralisation de la grippe a large spectre ciblee
EP2531511A1 (fr) * 2010-02-03 2012-12-12 Infinity Pharmaceuticals, Inc. Inhibiteurs de l'hydrolase d'amides d'acides gras
EP3338770B1 (fr) 2010-03-08 2023-06-07 Sloan-Kettering Institute For Cancer Research Inhibiteurs de la cdc7 kinase et leurs utilisations
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
WO2011119549A1 (fr) 2010-03-22 2011-09-29 President And Fellows Of Harvard College Trioxacarcines et utilisations de celles-ci
WO2011130332A1 (fr) 2010-04-12 2011-10-20 Academia Sinica Puces au glycane pour la recherche par criblage haut débit de virus
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (fr) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tretrazolones utilisées comme inhibiteurs de synthase d'acide gras
KR20130071433A (ko) 2010-05-07 2013-06-28 그린라이트 바이오사이언시스, 아이엔씨. 효소의 재배치를 통한 대사 경로에서의 흐름의 제어 방법
BR122020018191B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc. Uso de agentes de imagiologia na preparação de uma composição para imagiologia e método para imagiologia
EP2582836B1 (fr) 2010-06-18 2018-03-07 Taiho Pharmaceutical Co., Ltd. Modulateurs de prpk-tprkb et leurs utilisations
WO2012019168A2 (fr) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Acides nucléiques modifiés et leurs procédés d'utilisation
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
KR101988063B1 (ko) 2010-08-31 2019-09-30 그린라이트 바이오사이언시스, 아이엔씨. 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법
EP2616123A4 (fr) 2010-09-15 2014-11-26 Zogenix Inc Injecteurs sans aiguille et paramètres de conception associés optimisant les performances d'injection
WO2012040406A2 (fr) 2010-09-21 2012-03-29 Massachusetts Institute Of Technology Traitement et/ou caractérisation de la grippe ; polypeptides ha adaptés à l'homme
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
CA2821992A1 (fr) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Synthese d'acides nucleiques et methodes d'utilisation associees
BR112013007946B1 (pt) 2010-10-04 2022-07-12 Massachusetts Institute Of Technology Composições farmacêuticas e imunogênicas compreendendo polipeptídeos de hemaglutinina
EP2637669A4 (fr) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Composés hétérocycliques et utilisations de ceux-ci
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
WO2012099942A2 (fr) 2011-01-19 2012-07-26 Terakine Therapeutics, Inc. Méthodes et compositions pour traitement de syndrome métabolique
KR20190014125A (ko) 2011-01-24 2019-02-11 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
EP2667945A1 (fr) 2011-01-24 2013-12-04 Anterios, Inc. Compositions d'huile
WO2012103035A1 (fr) 2011-01-24 2012-08-02 Anterios, Inc. Compositions de nanoparticules
MX2013010076A (es) 2011-03-03 2014-04-07 Tersus Pharmaceuticals Llc Composiciones y metodos que comprenden c16:1n7 palmitoleato.
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
WO2012135615A2 (fr) 2011-03-30 2012-10-04 Brown University Enopeptines, utilisations de celles-ci, et procédés de synthèse de celles-ci
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
SG194733A1 (en) 2011-05-17 2013-12-30 Glaxosmithkline Biolog Sa Vaccine against streptococcus pneumoniae
JP6061922B2 (ja) 2011-06-22 2017-01-18 ザ ジェネラル ホスピタル コーポレイション プロテイノパチーの処置方法
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
TWI565709B (zh) 2011-07-19 2017-01-11 英菲尼提製藥股份有限公司 雜環化合物及其用途
RS58438B1 (sr) 2011-07-22 2019-04-30 Massachusetts Inst Technology Aktivatori klase i histonskih deacetilaza (hdacs) i njihova primena
WO2013032591A1 (fr) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Composés hétérocycliques et leurs utilisations
WO2013036787A2 (fr) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Préparation de carbapénèmes effectuée sans cellules
KR20210033558A (ko) 2011-09-09 2021-03-26 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
EP3384938A1 (fr) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Acides nucléiques techniques et leurs procédés d'utilisation
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
EP3492109B1 (fr) 2011-10-03 2020-03-04 ModernaTX, Inc. Nucléosides, nucléotides et acides nucléiques modifiés et leurs utilisations
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
AU2012340200B2 (en) 2011-11-17 2017-10-12 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-Terminal Kinase (JNK)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
ES2761200T3 (es) 2011-12-16 2020-05-19 Univ Florida Usos de análogos de 4'-desferritiocina
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
CN104159627A (zh) * 2012-01-06 2014-11-19 Svw科技私人有限公司 用于动物阉割的方法和装置
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US10106833B2 (en) 2012-04-06 2018-10-23 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US9902985B2 (en) 2012-04-06 2018-02-27 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2841128A4 (fr) 2012-04-23 2015-11-25 Zogenix Inc Fermetures à piston pour capsules d'administration de médicament
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
CN109265541A (zh) 2012-05-10 2019-01-25 麻省理工学院 流感中和药剂
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2014031498A1 (fr) 2012-08-18 2014-02-27 Academia Sinica Sondes perméables aux cellules pour l'identification et l'imagerie de sialidases
RS61957B1 (sr) 2012-09-26 2021-07-30 Harvard College Uvezani peptidi blokirani prolinom i njihove upotrebe
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
EP2909204B1 (fr) 2012-10-12 2018-12-05 The Broad Institute, Inc. Inhibiteurs de gsk3 et leurs procédés d'utilisation
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
WO2014063061A1 (fr) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Petites molécules marquées de façon hydrophobe en tant qu'inducteurs de la dégradation de protéine
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
MX2020009849A (es) 2012-11-01 2021-09-13 Infinity Pharmaceuticals Inc Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa.
US9567301B2 (en) 2012-11-02 2017-02-14 Dana-Farber Cancer Institute, Inc. Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
EP2922542A4 (fr) 2012-11-21 2016-10-05 Topokine Therapeutics Inc Méthodes et compositions pour augmenter localement la graisse corporelle
US9775915B2 (en) 2012-11-26 2017-10-03 President And Fellows Of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
LT2922554T (lt) 2012-11-26 2022-06-27 Modernatx, Inc. Terminaliai modifikuota rnr
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
CA2899363A1 (fr) 2012-12-21 2014-06-26 Epizyme, Inc. Inhibiteurs de prmt5 et leurs utilisations
DK2935222T3 (en) 2012-12-21 2019-01-07 Epizyme Inc PRMT5 INHIBITORS AND APPLICATIONS THEREOF
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
WO2014113089A2 (fr) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Polynucléotides capteurs de signal servant à modifier les phénotypes cellulaires
BR112015018503A2 (pt) 2013-02-07 2017-07-18 Massachusetts Inst Technology adaptação humana do influenza h5
WO2014124228A1 (fr) 2013-02-07 2014-08-14 Children's Medical Center Corporation Antigènes de protéine qui confèrent une protection contre une colonisation et/ou une maladie pneumococcique
EP2986278A1 (fr) 2013-03-11 2016-02-24 DURECT Corporation Composition injectable à libération contrôlée comprenant un véhicule liquide à haute viscosité
AU2014244232B2 (en) 2013-03-13 2019-05-02 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
EP2970194A1 (fr) 2013-03-15 2016-01-20 Infinity Pharmaceuticals, Inc. Sels et formes solides d'isoquinolinones et compositions les comprenant et procédés pour les utiliser
WO2014165679A1 (fr) 2013-04-03 2014-10-09 Allertein Therapeutics, Llc Nouvelles compositions de nanoparticules
KR102528984B1 (ko) 2013-04-04 2023-05-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 매크롤라이드 그리고 그의 제조방법 및 용도
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US10301359B2 (en) 2013-04-30 2019-05-28 Massachusetts Institute Of Technology Human adaptation of H3 influenza
WO2014179562A1 (fr) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology Dérivés de 1,3,5-triazinane-2,4,6-trione et leurs utilisations
NO2753788T3 (fr) 2013-05-10 2018-06-16
US20140377258A1 (en) 2013-05-30 2014-12-25 Infinity Pharmaceuticals, Inc. Treatment Of Cancers Using PI3 Kinase Isoform Modulators
WO2014197723A2 (fr) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Adaptation humaine de h7 ha
EP3030239A4 (fr) 2013-06-11 2017-03-08 Kala Pharmaceuticals, Inc. Dérivés de l'urée et leurs utilisations
EP3008081B1 (fr) 2013-06-14 2017-08-30 President and Fellows of Harvard College Modulateurs stabilisés du récepteur de l'insuline polypeptidique
WO2014210397A1 (fr) 2013-06-26 2014-12-31 Academia Sinica Antigènes rm2 et leur utilisation
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
RU2016105108A (ru) 2013-07-25 2017-08-30 Дана-Фарбер Кэнсер Инститьют, Инк. Ингибиторы факторов транскрипции и их применение
CN105555304A (zh) 2013-08-05 2016-05-04 葛兰素史密丝克莱恩生物有限公司 联合免疫原性组合物
EP3460069B1 (fr) 2013-08-05 2021-10-20 Greenlight Biosciences, Inc. Composés thérapeutiquement actifs et leurs procédés d'utilisation
CA2923579C (fr) 2013-09-06 2023-09-05 Academia Sinica Activation des cellules humaines inkt a l'aide de glycolipides ayant des groupes glycolsyles modifies
ES2900806T3 (es) 2013-10-04 2022-03-18 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos
WO2015051241A1 (fr) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
WO2015057894A1 (fr) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Méthodes de traitement d'une maladie polykystique rénale et d'une maladie polykystique du foie
WO2015057958A2 (fr) 2013-10-16 2015-04-23 Massachusetts Institute Of Technology Conjugués d'entérobactine et leurs utilisations
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
CA2927917C (fr) 2013-10-18 2022-08-09 Syros Pharmaceuticals, Inc. Composes heteroaromatiques utiles pour le traitement des maladies proliferatives
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX355330B (es) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapeuticos y sus usos.
EA201891279A1 (ru) 2013-12-24 2019-01-31 Президент Энд Феллоус Оф Гарвард Колледж Аналоги кортистатина, их синтез и применения
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017507118A (ja) 2014-01-16 2017-03-16 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ がんの処置および検出のための組成物および方法
MX2016008549A (es) 2014-01-27 2016-09-26 Te Pari Products Ltd Dispensador de fluido.
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
MX2016011517A (es) 2014-03-07 2017-04-13 Univ Arizona Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico.
JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
CN106415244B (zh) 2014-03-27 2020-04-24 中央研究院 反应性标记化合物及其用途
WO2015149016A2 (fr) 2014-03-28 2015-10-01 University Of Washington Through Its Center For Commercialization Vaccins contre le cancer du sein et des ovaires
WO2015164604A1 (fr) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Inhibiteurs de janus kinase marqués de manière hydrophobe et utilisations associées
WO2015164614A1 (fr) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Inhibiteurs de janus kinase et leurs utilisations
WO2015168079A1 (fr) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k
WO2015168380A1 (fr) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Immunisation à base de sidérophores contre les bactéries gram-négatives
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP3149045B1 (fr) 2014-05-27 2023-01-18 Academia Sinica Compositions et procédés concernant des glycoformes universelles pour une efficacité d'anticorps améliorée
JP7062361B2 (ja) 2014-05-27 2022-05-06 アカデミア シニカ 抗ｈｅｒ２糖操作抗体群およびその使用
WO2015184004A1 (fr) 2014-05-27 2015-12-03 Academia Sinica Glycoanticorps anti-cd20 et leurs utilisations
CA2950433A1 (fr) 2014-05-28 2015-12-03 Academia Sinica Glycoanticorps anti-thf-alpha et leurs utilisations
EP3154576A1 (fr) 2014-06-13 2017-04-19 GlaxoSmithKline Biologicals S.A. Combinaisons immunogènes
US10227342B2 (en) 2014-06-19 2019-03-12 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
WO2015200425A1 (fr) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Forme posologique à usage topique
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
CN106715458A (zh) 2014-07-18 2017-05-24 华盛顿大学 癌症疫苗组合物及其使用方法
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
EP3191500A4 (fr) 2014-09-08 2018-04-11 Academia Sinica Activation des cellules inkt humaines par des glycolipides
WO2016049359A1 (fr) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2015335950B2 (en) 2014-10-21 2018-01-25 Takeda Pharmaceutical Company Limited Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl}pyrimidine-2,4-diamine
JP2017533238A (ja) 2014-10-28 2017-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗原特異的寛容のための組成物及び方法
WO2016077125A1 (fr) 2014-11-10 2016-05-19 Moderna Therapeutics, Inc. Molécules d'acide nucléique de remplacement contenant une quantité réduite d'uracile et utilisations associées
WO2016086026A1 (fr) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Formes cristallines d'un composé thérapeutique et utilisations associées
CA2969467A1 (fr) 2014-12-10 2016-06-16 Kala Pharmaceuticals, Inc. Derive d'uree a substitution 1-amino-triazolo(1,5-a)pyridine et utilisations de celui-ci
EP3037119A1 (fr) * 2014-12-23 2016-06-29 Hipra Scientific, S.L.U. Dispositif pour l'administration de produits médicaux
JP6854762B2 (ja) 2014-12-23 2021-04-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
AU2015369707B2 (en) 2014-12-23 2020-07-23 Sloan-Kettering Institute For Cancer Research Polymorph of granaticin B
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
EP3248005B1 (fr) 2015-01-24 2020-12-09 Academia Sinica Nouveaux composés conjugués de glycane et leurs méthodes d'utilisation
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
EP3273966B1 (fr) 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Inhibiteurs de kinases cycline-dépendantes
KR20180002636A (ko) 2015-03-30 2018-01-08 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
WO2016176343A1 (fr) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Agents chélateurs métalliques programmés métaboliquement et leurs utilisations
WO2016178591A2 (fr) 2015-05-05 2016-11-10 Gene Predit, Sa Marqueurs génétiques et traitement de l'obésité masculine
EP3307728A4 (fr) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases
FI3310764T3 (fi) 2015-06-19 2023-07-18 Massachusetts Inst Technology Alkenyylillä substituoidut 2,5-piperatsiinidionit ja niiden käyttö koostumuksissa agenssin kuljettamiseksi subjektille tai soluun
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
JP7028766B2 (ja) 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
HUE057613T2 (hu) 2015-09-17 2022-05-28 Modernatx Inc Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására
AU2016324463B2 (en) 2015-09-17 2022-10-27 Modernatx, Inc. Polynucleotides containing a stabilizing tail region
EP3355882A1 (fr) 2015-10-01 2018-08-08 Kythera Biopharmaceuticals, Inc. Compositions comprenant une statine pour une utilisation dans des procédés d'adipolyse
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
DK3394030T3 (da) 2015-12-22 2022-03-28 Modernatx Inc Forbindelser og sammensætninger til intracellulær afgivelse af midler
CA3016170A1 (fr) 2016-03-08 2017-09-14 Academia Sinica Procedes de synthese modulaire de n-glycanes et de puces a n-glycanes
WO2017161116A1 (fr) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k
KR20230079463A (ko) 2016-04-06 2023-06-07 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
IL312520A (en) 2016-06-03 2024-07-01 Sanofi Pasteur Inc Modification of transgenic influenza hemagglutinin polypeptides
WO2017214337A1 (fr) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Polymères d'administration de médicament et leurs utilisations
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2017286606A1 (en) 2016-06-14 2018-12-13 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
TWI789357B (zh) 2016-08-05 2023-01-11 南韓商Ｓｋ生物科技股份有限公司 多價肺炎球菌多醣-蛋白質共軛物組成物(二)
CA3031797A1 (fr) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Composition d'un conjugue polysaccharide-proteine pneumococcique multivalent
KR102588027B1 (ko) 2016-08-22 2023-10-12 초 파마 인크. 항체, 결합 단편 및 사용 방법
CN106345010B (zh) * 2016-08-24 2019-08-23 吉林省农业科学院 一种具有存储功能的动物用注射装置
SG10201609111WA (en) 2016-10-31 2018-05-30 Miracle Man Pte Ltd Safety-Enhanced Needle-Free Injector And System For Use Through Both Porous And Non-Porous Materials
JP6801381B2 (ja) * 2016-11-07 2020-12-16 東ソー株式会社 凍結乾燥状態の検体前処理試薬
EP3538067A1 (fr) 2016-11-08 2019-09-18 Modernatx, Inc. Formulations stabilisées de nanoparticules lipidiques
WO2018106738A1 (fr) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Polymères en étoile à bras en brosse, conjugués et particules, et leurs utilisations
DE102017102765A1 (de) 2017-02-13 2018-08-16 Rudolf Götz Kit-of-Parts
US11969506B2 (en) 2017-03-15 2024-04-30 Modernatx, Inc. Lipid nanoparticle formulation
FI3596041T3 (fi) 2017-03-15 2023-01-31 Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään
EP3601326A4 (fr) 2017-03-20 2020-12-16 The Broad Institute, Inc. Composés et méthodes de régulation de sécrétion d'insuline
US11203601B2 (en) 2017-04-05 2021-12-21 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
WO2018232120A1 (fr) 2017-06-14 2018-12-20 Modernatx, Inc. Composés et compositions pour l'administration intracellulaire d'agents
CN107252512B (zh) * 2017-06-16 2018-03-13 南阳市中心医院 一种气动无针注射器
SG11201912601RA (en) 2017-06-23 2020-01-30 Nosocomial Vaccine Corp Immunogenic compositions
WO2019013790A1 (fr) 2017-07-12 2019-01-17 Curza Global, Llc Composés antimicrobiens et leurs utilisations
WO2019013789A1 (fr) 2017-07-12 2019-01-17 Curza Global, Llc Composés antimicrobiens
WO2019046809A1 (fr) 2017-08-31 2019-03-07 Modernatx, Inc. Procédés de fabrication de nanoparticules lipidiques
KR102571743B1 (ko) 2017-10-11 2023-08-29 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물
WO2019109079A1 (fr) 2017-12-01 2019-06-06 North Carolina State University Particules de fibrine et leurs méthodes de production
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
DE102018107103A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102018107102A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102018107101A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
US20220409536A1 (en) 2018-09-19 2022-12-29 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
EP3852728B1 (fr) 2018-09-20 2024-09-18 ModernaTX, Inc. Préparation de nanoparticules lipidiques et leurs méthodes d'administration
US10953213B2 (en) * 2018-10-22 2021-03-23 Carson B. Vester Tattoo device
WO2020150385A1 (fr) 2019-01-16 2020-07-23 Curza Global, Llc Composés antimicrobiens et procédés
EP3911643A1 (fr) 2019-01-16 2021-11-24 Curza Global LLC Composés antimicrobiens et procédés
EP4427739A3 (fr) 2019-01-31 2024-10-16 ModernaTX, Inc. Procédés de préparation de nanoparticules lipidiques
WO2020168466A1 (fr) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Nucléoside modifié et procédés de synthèse associés
WO2020205615A1 (fr) * 2019-03-29 2020-10-08 Aijex Pharma International, Inc. Injecteur sans aiguille et procédés associés
EP4003410A1 (fr) 2019-07-31 2022-06-01 Sanofi Pasteur, Inc. Compositions de conjugués de polysaccharide-protéine pneumococcique multivalents leurs méthodes d'utilisation
US20220280639A1 (en) 2019-07-31 2022-09-08 Modernatx, Inc. Compositions and methods for delivery of rna interference agents to immune cells
DE102019123733A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123732A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123737A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123734A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123731A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
WO2021097061A1 (fr) 2019-11-13 2021-05-20 Curza Global, Llc Composés antimicrobiens et procédés
KR102518758B1 (ko) * 2020-01-21 2023-04-06 미라클스코프(주) 무침주사기
BR112022014970A2 (pt) 2020-01-31 2022-09-20 Modernatx Inc Métodos para preparar nanopartículas lipídicas
US11642407B2 (en) 2020-02-28 2023-05-09 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
RU200703U1 (ru) * 2020-03-20 2020-11-06 Общество с ограниченной ответственностью "АТ-ЛИРТ" Жидкостный насос для хемилюминесцентных измерений с борта летательных аппаратов
WO2021231729A1 (fr) 2020-05-13 2021-11-18 Sanofi Nanoparticules d'hémagglutinine de souche stabilisée avec adjuvant et méthodes d'utilisation de celles-ci pour induction d'anticorps antigrippaux largement neutralisants
KR102427261B1 (ko) * 2020-06-15 2022-08-02 유수옥 주사기
DE102020119751A1 (de) 2020-07-27 2022-01-27 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CN116710116A (zh) 2020-10-30 2023-09-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 β折叠股桥肽
JPWO2022092294A1 (fr) 2020-10-30 2022-05-05
TW202237068A (zh) 2020-12-09 2022-10-01 美商建南德克公司 製備脂質奈米顆粒的高通量方法及其用途
KR102669122B1 (ko) * 2020-12-22 2024-05-27 조민수 자동 무침 주사기
EP4305088A1 (fr) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Poly (aminoesters) ramifiés pour l'administration d'acides nucléiques
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
JP2024532763A (ja) 2021-08-11 2024-09-10 サノフィ パスツール インコーポレイテッド 切断型インフルエンザノイラミニダーゼおよびこれを使用する方法
WO2023039108A1 (fr) 2021-09-08 2023-03-16 Affinivax, Inc. Vaccin anti-coronavirus
KR20240076825A (ko) 2021-10-08 2024-05-30 사노피 파스퇴르 인크 다가 인플루엔자 백신
WO2023081798A1 (fr) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Vaccins contre la grippe multivalents comprenant de l'hémagglutinine et de la neuraminidase recombinantes et leurs méthodes d'utilisation
WO2023079113A1 (fr) 2021-11-05 2023-05-11 Sanofi Vaccins contre la grippe multivalents hybrides comprenant de l'hémagglutinine et de la neuraminidase et leurs procédés d'utilisation
EP4447943A1 (fr) 2021-12-16 2024-10-23 ModernaTX, Inc. Procédés de préparation de nanoparticules lipidiques
CA3240195A1 (fr) 2021-12-30 2023-07-06 Paul R. Sebahar Composes antimicrobiens et procedes
WO2023145735A1 (fr) 2022-01-25 2023-08-03 元詞 早野 Thérapie et prévention innovantes pour supprimer les troubles liés au vieillissement, notamment la sarcopénie
CN118591621A (zh) 2022-01-27 2024-09-03 赛诺菲巴斯德有限公司 修饰的Vero细胞及其用于病毒生产的方法
WO2023177579A1 (fr) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Techniques d'apprentissage automatique dans la conception de protéines pour la génération de vaccins
WO2023193002A1 (fr) 2022-04-01 2023-10-05 Modernatx, Inc. Mélangeurs en croix pour la production de nanoparticules lipidiques, et procédés de fonctionnement y relatifs
WO2023235380A1 (fr) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides pour le traitement de maladies génétiques
WO2023250513A1 (fr) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. Composés macrolides à 13 chaînons pour le traitement de maladies médiées par une traduction de protéine anormale
WO2024026487A1 (fr) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions de nanoparticules lipidiques comprenant des dérivés phospholipidiques et utilisations associées
WO2024026475A1 (fr) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions pour administration à des cellules souches et progénitrices hématopoïétiques (hspc) et utilisations associées
WO2024026482A1 (fr) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions de nanoparticules lipidiques comprenant des dérivés lipidiques de surface et utilisations associées
WO2024049994A1 (fr) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Traitement de la polypose adénomateuse familiale à l'aide d'un macrolide à 13 chaînons
WO2024091918A2 (fr) 2022-10-25 2024-05-02 Modernatx, Inc. Procédés de production de nanoparticules lipidiques dans des mélangeurs croisés
WO2024121380A1 (fr) 2022-12-08 2024-06-13 Pierre Fabre Medicament Composition vaccinale et adjuvant

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2398544A (en) * 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
FR1049564A (fr) * 1951-11-22 1953-12-30 Normeca Seringue à injection perfectionnée
US2762369A (en) * 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector with adjustable impact plunger
GB789029A (en) * 1954-10-27 1958-01-15 Astra Apotekarnes Kem Fab Improvements in hypodermic syringes
GB805184A (en) * 1957-01-29 1958-12-03 Becton Dickinson Co Hypodermic assembly
US2928390A (en) * 1957-07-15 1960-03-15 Scherer Corp R P Multi-dose hypodermic injector
GB915262A (en) * 1957-11-01 1963-01-09 Secr Aviation Improvements in/or relating to hypodermic injection apparatus
CH393640A (de) * 1960-06-10 1965-06-15 Int Treuhand Ag Spritzampulle
GB993309A (en) * 1961-04-11 1965-05-26 Express Injector Company Ltd Improved hypodermic injector
GB971162A (en) * 1961-11-21 1964-09-30 British Oxygen Co Ltd Injection inoculation instruments
GB1052043A (en) * 1962-10-02 1966-12-21 Benger Lab Ltd Hypodermic injection device
US3330276A (en) * 1963-10-07 1967-07-11 Scherer Corp R P Hypodermic jet injector
US3526225A (en) * 1967-03-31 1970-09-01 Tokyo Sokuhan Kk Jet-type hypodermic injection device
BE755224A (fr) * 1969-08-25 1971-02-24 Philips Nv Seringue d'injection
BE795162A (fr) * 1972-02-10 1973-08-08 Philips Nv Injektie-inrichting
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US3859996A (en) * 1973-07-18 1975-01-14 Mizzy Inc Multi-dose injector
US3882863A (en) * 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4031893A (en) * 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
SU718111A1 (ru) * 1978-07-12 1980-02-29 Предприятие П/Я А-3556 Безыгольный инъектор
DE3069253D1 (en) * 1980-02-19 1984-10-31 Wardlaw Stephen C Hypodermic syringes
US4329988A (en) * 1980-12-23 1982-05-18 Survival Technology, Inc. Plural injection assembly
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
DE3278101D1 (en) * 1981-08-10 1988-03-17 Duphar Int Res Automatic injection syringe
ATE23802T1 (de) * 1982-10-27 1986-12-15 Duphar Int Res Automatische injektionsvorrichtung.
FR2539302B1 (fr) * 1983-01-17 1986-03-14 Brunet Jean Louis Seringue a usage medical
DE3342407A1 (de) * 1983-11-24 1985-06-05 Erwin 6950 Mosbach Maurer Injektionsgeraet
US4484910A (en) * 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
US4578064A (en) * 1983-12-21 1986-03-25 Survival Technology Inc. Plural dosage automatic injector with improved safety
FR2567760A1 (fr) * 1984-07-18 1986-01-24 Hibon Joseph Appareil pour executer des series d'injections medicamenteuses
DE3427189A1 (de) * 1984-07-24 1986-02-20 Hoechst Ag, 6230 Frankfurt Verriegelung fuer die abnehmbare impfstoffpumpe eines nadellosen injektionsgeraetes
BR8404286A (pt) * 1984-08-28 1986-04-08 Sergio Landau Seringa hipodermica a pressao
DE3566866D1 (en) * 1984-11-02 1989-01-26 Duphar Int Res Automatic injection device
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
ES2017924B3 (es) * 1985-10-11 1991-03-16 Duphar Int Res B V Inyector automatico.
DE3773048D1 (de) * 1986-05-15 1991-10-24 Duphar Int Res Automatische injektionsspritze.
FR2609400A2 (fr) * 1986-06-16 1988-07-15 Michel Pistor Dispositif therapeutique, portable, totalement autonome, transdermique, pourvu de moyens d'introduction d'un agent a activite therapeutique dans un reservoir du dispositif a un moment quelconque
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US4850968A (en) * 1987-07-27 1989-07-25 Ar.Ma.S.R.L. Self-blocking hypodermic syringe for once-only use, comprising a needle protection cap
JPH01198561A (ja) * 1987-11-16 1989-08-10 Medhi Tek Internatl Ltd 液体注入装置
US4874367A (en) * 1988-02-05 1989-10-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
BR8801952A (pt) * 1988-04-22 1989-11-14 Sergio Landau Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
JPH0284962A (ja) * 1988-06-14 1990-03-26 Vci Corp 負圧圧着無針注射器
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
GB8819977D0 (en) * 1988-08-23 1988-09-21 Medimech Ltd Automatic injectors
DE8813905U1 (de) * 1988-11-07 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
DE8813938U1 (de) * 1988-11-08 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
EP0405320A3 (en) * 1989-06-27 1991-04-03 Elkom - Tovarna Stikalnih Naprav Multipurpose automatic injector
US5085641A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
FR2651314A1 (fr) * 1989-08-25 1991-03-01 Taddei Andre Dispositif portatif pour effectuer des dosages multiples d'un produit liquide ou pateux.
AU6550990A (en) * 1989-11-09 1991-05-16 Bioject, Inc. Needleless hypodermic injection device
WO1991012839A1 (fr) * 1990-03-02 1991-09-05 Igor Alexandrovich Khanin Injecteur a aiguille-jet destine a l'introduction de preparations medicales dans un organe interne d'un patient
DE4008068A1 (de) * 1990-03-14 1991-09-19 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
US5092843A (en) * 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
DE9005419U1 (de) * 1990-05-12 1990-07-19 Nothdurft, Klaus, 7000 Stuttgart Betätigungsvorrichtung für eine Einmalspritze
CA2095858A1 (fr) * 1990-11-09 1992-05-10 Peter Elliott Rosenzweig Pistolet a injection sous-cutanee sans aiguille
GB9100819D0 (en) * 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
FR2671729A1 (fr) * 1991-01-17 1992-07-24 Micro Dose Pharma Dispositif de delivrance de doses controlees, en particulier du genre seringue a insuline jetable.
US5176643A (en) * 1991-04-29 1993-01-05 George C. Kramer System and method for rapid vascular drug delivery
EP0584207A1 (fr) * 1991-05-13 1994-03-02 Sti International Limited Injecteurs automatiques
GB9111600D0 (en) * 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
EP0518416A1 (fr) * 1991-06-13 1992-12-16 Duphar International Research B.V Dispositif d'injection
DE4120267A1 (de) * 1991-06-19 1992-12-24 Bader & Partner Medizintechnik Verfahren zum betrieb einer vorrichtung zur abgabe eines fluessigen medizinischen behandlungsstoffes an einen zu behandelnden koerper und vorrichtung zur durchfuehrung des verfahrens
DE59202070D1 (de) * 1991-07-24 1995-06-08 Medico Dev Investment Co Injektor.
JP3785186B2 (ja) * 1992-01-07 2006-06-14 エスティーアイ インターナショナル リミテッド 自動式注射器
EP0562671B1 (fr) * 1992-03-27 1996-05-29 Duphar International Research B.V Seringue automatique
IL105706A (en) * 1992-05-15 1996-10-16 Safe T Ltd Dispensing device for hollow needles
US5334144A (en) * 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector

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NO940606L (no) 1994-04-21
EP0599940A1 (fr) 1994-06-08
DE69223793T2 (de) 1998-04-23
ES2110513T3 (es) 1998-02-16
NO307817B1 (no) 2000-06-05
CA2116341A1 (fr) 1993-03-04
JP3257794B2 (ja) 2002-02-18
KR100233339B1 (ko) 1999-12-01
JP3257795B2 (ja) 2002-02-18
GB9118204D0 (en) 1991-10-09
NO940606D0 (no) 1994-02-22
JPH07500417A (ja) 1995-01-12
RU2129445C1 (ru) 1999-04-27
RU94028893A (ru) 1996-06-10
CA2116341C (fr) 1999-12-14
EP0599940B1 (fr) 1997-12-29
US5480381A (en) 1996-01-02
ATE161427T1 (de) 1998-01-15
JPH06509954A (ja) 1994-11-10
BR9206407A (pt) 1994-12-13
DE69223793D1 (de) 1998-02-05
AU2444592A (en) 1993-03-16
WO1993003779A1 (fr) 1993-03-04

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