GB2284760B - A method of preparing pharmaceutical compositions by melt pelletisation - Google Patents

A method of preparing pharmaceutical compositions by melt pelletisation

Info

Publication number
GB2284760B
GB2284760B GB9324045A GB9324045A GB2284760B GB 2284760 B GB2284760 B GB 2284760B GB 9324045 A GB9324045 A GB 9324045A GB 9324045 A GB9324045 A GB 9324045A GB 2284760 B GB2284760 B GB 2284760B
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical compositions
preparing pharmaceutical
pelletisation
melt
melt pelletisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9324045A
Other languages
English (en)
Other versions
GB2284760A (en
GB9324045D0 (en
Inventor
Ronald Brown Miller
Stewart Thomas Leslie
Sandra Therese Antoi Malkowska
Derek Allan Prater
Trevor John Knott
Joanne Heafield
Deborah Challis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Priority to GB9324045A priority Critical patent/GB2284760B/en
Publication of GB9324045D0 publication Critical patent/GB9324045D0/en
Priority to NZ260408A priority patent/NZ260408A/en
Priority to IL109460A priority patent/IL109460A/en
Priority to IL11966094A priority patent/IL119660A/en
Priority to AT04014719T priority patent/ATE303140T1/de
Priority to PT95114527T priority patent/PT699436E/pt
Priority to DK95114527.5T priority patent/DK0699436T4/da
Priority to ES09004973T priority patent/ES2331046T1/es
Priority to DK04014719T priority patent/DK1468679T3/da
Priority to DE69427472T priority patent/DE69427472T3/de
Priority to ES04030658T priority patent/ES2346651T3/es
Priority to EP96101147A priority patent/EP0729751A1/en
Priority to AT04030658T priority patent/ATE468850T1/de
Priority to DE0729751T priority patent/DE729751T1/de
Priority to EP04014719A priority patent/EP1468679B1/en
Priority to ES94303128T priority patent/ES2088312T3/es
Priority to PT04030658T priority patent/PT1527775E/pt
Priority to AT95114527T priority patent/ATE201989T1/de
Priority to EP04030658A priority patent/EP1527775B1/en
Priority to AT94303128T priority patent/ATE138566T1/de
Priority to DE09004973T priority patent/DE09004973T8/de
Priority to DE0699436T priority patent/DE699436T1/de
Priority to EP94303128A priority patent/EP0624366B1/en
Priority to PT04014719T priority patent/PT1468679E/pt
Priority to SG1996008705A priority patent/SG67347A1/en
Priority to DE69400215T priority patent/DE69400215T2/de
Priority to EP95114527A priority patent/EP0699436B2/en
Priority to DE9422335U priority patent/DE9422335U1/de
Priority to EP09004973.5A priority patent/EP2103303B1/en
Priority to DK94303128.6T priority patent/DK0624366T3/da
Priority to DE69435295T priority patent/DE69435295D1/de
Priority to ES04014719T priority patent/ES2247574T3/es
Priority to ES95114527T priority patent/ES2159591T5/es
Priority to DK04030658.1T priority patent/DK1527775T3/da
Priority to DE69434479T priority patent/DE69434479T2/de
Priority to CZ19941093A priority patent/CZ288517B6/cs
Priority to FI942092A priority patent/FI942092L/fi
Priority to HU9401478A priority patent/HU228177B1/hu
Priority to EG26394A priority patent/EG20577A/xx
Priority to CA002123160A priority patent/CA2123160C/en
Priority to AU61963/94A priority patent/AU6196394A/en
Priority to NO941719A priority patent/NO306446B1/no
Priority to SK541-94A priority patent/SK279971B6/sk
Priority to IDP991104D priority patent/ID25988A/id
Priority to JP6096671A priority patent/JP3045924B2/ja
Priority to SK1437-98A priority patent/SK283143B6/sk
Priority to CN94105356A priority patent/CN1094755C/zh
Priority to US08/241,129 priority patent/US5591452A/en
Priority to TW085103273A priority patent/TW496736B/zh
Priority to IL10994494A priority patent/IL109944A/en
Priority to SG1996009186A priority patent/SG50706A1/en
Priority to AT94304144T priority patent/ATE172376T1/de
Priority to DK94304144T priority patent/DK0636370T4/da
Priority to ES94304144T priority patent/ES2124372T5/es
Priority to EP94304144A priority patent/EP0636370B2/en
Priority to DE69414046T priority patent/DE69414046T3/de
Priority to SK763-94A priority patent/SK280534B6/sk
Priority to CZ19941550A priority patent/CZ287918B6/cs
Priority to NZ260883A priority patent/NZ260883A/en
Priority to AU66105/94A priority patent/AU6610594A/en
Priority to FI943141A priority patent/FI114285B/fi
Priority to PL94304062A priority patent/PL179282B1/pl
Priority to NO942470A priority patent/NO306449B1/no
Priority to CA002127166A priority patent/CA2127166C/en
Priority to JP15121994A priority patent/JP3647897B2/ja
Priority to KR1019940015740A priority patent/KR100365572B1/ko
Priority to HU9402007A priority patent/HU220075B/hu
Priority to BG99077A priority patent/BG62316B1/bg
Priority to BG99078A priority patent/BG62473B1/bg
Priority to EG61694A priority patent/EG20600A/xx
Priority to ES94308493T priority patent/ES2168290T3/es
Priority to AT94308493T priority patent/ATE212224T1/de
Priority to DE69429710T priority patent/DE69429710T2/de
Priority to DK94308493T priority patent/DK0654263T3/da
Priority to PT94308493T priority patent/PT654263E/pt
Priority to EP94308493A priority patent/EP0654263B1/en
Priority to NZ264953A priority patent/NZ264953A/en
Priority to IN1134MA1994 priority patent/IN179010B/en
Priority to IL11170994A priority patent/IL111709A/en
Priority to BG99198A priority patent/BG62429B1/bg
Priority to CZ19942866A priority patent/CZ289650B6/cs
Priority to SK1406-94A priority patent/SK280496B6/sk
Priority to FI945476A priority patent/FI113335B/fi
Priority to HU9403353A priority patent/HU217205B/hu
Priority to NO19944473A priority patent/NO314124B1/no
Priority to EG74294A priority patent/EG20910A/xx
Priority to PL94305939A priority patent/PL178883B1/pl
Priority to CN94118503A priority patent/CN1121213C/zh
Priority to ZA949296A priority patent/ZA949296B/xx
Priority to KR1019940031398A priority patent/KR100354702B1/ko
Priority to AU79015/94A priority patent/AU682223C/en
Priority to JP28993694A priority patent/JP3411114B2/ja
Priority to US08/449,772 priority patent/US6326027B1/en
Publication of GB2284760A publication Critical patent/GB2284760A/en
Priority to US08/607,852 priority patent/US5849240A/en
Priority to US08/607,851 priority patent/US5891471A/en
Priority to IN747MA1996 priority patent/IN182557B/en
Priority to GR960401422T priority patent/GR3020084T3/el
Priority to US08/677,798 priority patent/US6254887B1/en
Priority to IL11966096A priority patent/IL119660A0/xx
Priority to US08/843,571 priority patent/US5879705A/en
Priority to US08/944,106 priority patent/US5965163A/en
Priority to AU39957/97A priority patent/AU3995797A/en
Priority to AU52995/98A priority patent/AU722358B2/en
Application granted granted Critical
Publication of GB2284760B publication Critical patent/GB2284760B/en
Priority to JP22971898A priority patent/JP3267561B2/ja
Priority to US09/264,399 priority patent/US6143328A/en
Priority to CNB991066421A priority patent/CN1146410C/zh
Priority to NO19993484A priority patent/NO313124B1/no
Priority to US09/370,270 priority patent/US6162467A/en
Priority to AT0081699U priority patent/AT3413U3/de
Priority to US09/740,732 priority patent/US20010019725A1/en
Priority to US09/800,204 priority patent/US7074430B2/en
Priority to NO20013566A priority patent/NO331650B1/no
Priority to GR20010401419T priority patent/GR3036565T3/el
Priority to JP2001297270A priority patent/JP3443574B2/ja
Priority to JP2002271157A priority patent/JP2003113075A/ja
Priority to FI20030560A priority patent/FI121565B/fi
Priority to US11/435,015 priority patent/US20060269603A1/en
Priority to US12/152,474 priority patent/US20090117191A1/en
Priority to FI20105856A priority patent/FI122717B/fi
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB9324045A 1991-12-24 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation Expired - Lifetime GB2284760B (en)

Priority Applications (119)

Application Number Priority Date Filing Date Title
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation
NZ260408A NZ260408A (en) 1993-05-10 1994-04-27 Controlled release preparation comprising tramadol
IL109460A IL109460A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
IL11966094A IL119660A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
AT04014719T ATE303140T1 (de) 1993-05-10 1994-04-29 Tramadolhaltiges arzneimittel mit gesteuerter wirkstoffabgabe
PT95114527T PT699436E (pt) 1993-05-10 1994-04-29 Formulacao de libertacao controlada
DK95114527.5T DK0699436T4 (da) 1993-05-10 1994-04-29 Præparat med reguleret frigivelse
ES09004973T ES2331046T1 (es) 1993-05-10 1994-04-29 Formulacion de liberacion controlada.
DK04014719T DK1468679T3 (da) 1993-05-10 1994-04-29 Tramadolholdig formulering med styret frigivelse
DE69427472T DE69427472T3 (de) 1993-05-10 1994-04-29 Arzneimittel mit kontrollierter Wirkstoffabgabe
ES04030658T ES2346651T3 (es) 1993-05-10 1994-04-29 Formulacion de liberacion controlada que tramadol formulacion de liberacion controlada que contiene tramadol.
EP96101147A EP0729751A1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
AT04030658T ATE468850T1 (de) 1993-05-10 1994-04-29 Tramadolhaltiges arzneimittel mit gesteuerter wirkstoffabgabe
DE0729751T DE729751T1 (de) 1993-05-10 1994-04-29 Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe
EP04014719A EP1468679B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
ES94303128T ES2088312T3 (es) 1993-05-10 1994-04-29 Formulacion de liberacion controlada que contiene tramadol.
PT04030658T PT1527775E (pt) 1993-05-10 1994-04-29 FORMULAÆO DE LIBERTAÆO CONTROLADA QUE CONTéM TRAMADOL
AT95114527T ATE201989T1 (de) 1993-05-10 1994-04-29 Arzneimittel mit kontrollierter wirkstoffabgabe
EP04030658A EP1527775B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
AT94303128T ATE138566T1 (de) 1993-05-10 1994-04-29 Tramadol enthaltendes arzneimittel mit verzögerter wirkstoffabgabe
DE09004973T DE09004973T8 (de) 1993-05-10 1994-04-29 Formulierung mit gesteuerter Freisetzung
DE0699436T DE699436T1 (de) 1993-05-10 1994-04-29 Arzneimittel mit kontrollierter Wirkstoffabgabe
EP94303128A EP0624366B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
PT04014719T PT1468679E (pt) 1993-05-10 1994-04-29 Formulacao de libertacao controlada que contem tramadol
SG1996008705A SG67347A1 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE69400215T DE69400215T2 (de) 1993-05-10 1994-04-29 Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe
EP95114527A EP0699436B2 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE9422335U DE9422335U1 (de) 1993-05-10 1994-04-29 Formulierung mit kontrollierter Freisetzung
EP09004973.5A EP2103303B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DK94303128.6T DK0624366T3 (da) 1993-05-10 1994-04-29 Præparat indeholdende tramadol med reguleret frigivelse
DE69435295T DE69435295D1 (de) 1993-05-10 1994-04-29 Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe
ES04014719T ES2247574T3 (es) 1993-05-10 1994-04-29 Formulacion de liberacion controlada que comprende tramadol.
ES95114527T ES2159591T5 (es) 1993-05-10 1994-04-29 Formulación de liberación controlada
DK04030658.1T DK1527775T3 (da) 1993-05-10 1994-04-29 Tramadolholdig sammensætning med kontrolleret frigivelse
DE69434479T DE69434479T2 (de) 1993-05-10 1994-04-29 Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe
CZ19941093A CZ288517B6 (cs) 1993-05-10 1994-05-04 Farmaceutický prostředek v jednotkové dávkovací formě a způsob jeho přípravy
FI942092A FI942092L (fi) 1993-05-10 1994-05-06 Hallitusti vapauttava valmiste
HU9401478A HU228177B1 (en) 1993-05-10 1994-05-06 Controlled release formulation containing tramadol
EG26394A EG20577A (en) 1993-05-10 1994-05-08 Controlled release formulation contaning tramadol
CA002123160A CA2123160C (en) 1993-05-10 1994-05-09 Controlled release formulation
AU61963/94A AU6196394A (en) 1993-05-10 1994-05-09 Controlled release formulation
NO941719A NO306446B1 (no) 1993-05-10 1994-05-09 Oralt farmasöytisk preparat omfattende tramadol med regulert frigjöringsvirkning
SK541-94A SK279971B6 (sk) 1993-05-10 1994-05-10 Farmaceutický prostriedok v jednotkovej dávkovej f
IDP991104D ID25988A (id) 1993-05-10 1994-05-10 FORMULASI OBAT YANG LARUTNYA BISA DIATUR (Pecahan dari P-940726)
JP6096671A JP3045924B2 (ja) 1993-05-10 1994-05-10 放出が調整された経口薬剤調合物
SK1437-98A SK283143B6 (sk) 1993-05-10 1994-05-10 Farmaceutický prostriedok v jednotkovej dávkovej forme a spôsob jeho prípravy
CN94105356A CN1094755C (zh) 1993-05-10 1994-05-10 含反胺苯环醇或其盐的控制释放制剂
US08/241,129 US5591452A (en) 1993-05-10 1994-05-10 Controlled release formulation
TW085103273A TW496736B (en) 1993-05-10 1994-05-12 Controlled release formulation
IL10994494A IL109944A (en) 1993-07-01 1994-06-08 Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
SG1996009186A SG50706A1 (en) 1993-07-01 1994-06-09 Sustained release compositions and a method of preparing pharmaceutical compositions
AT94304144T ATE172376T1 (de) 1993-07-01 1994-06-09 Morphinenthaltende arzneizusammensetzungen mit verzögerter wirkstoffabgabe
DK94304144T DK0636370T4 (da) 1993-07-01 1994-06-09 Depotpræparater indeholdende morfin
ES94304144T ES2124372T5 (es) 1993-07-01 1994-06-09 Composiciones de liberacion sostenida que contienen morfina.
EP94304144A EP0636370B2 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine
DE69414046T DE69414046T3 (de) 1993-07-01 1994-06-09 Morphinenthaltende Arzneizusammensetzungen mit verzögerter Wirkstoffabgabe
SK763-94A SK280534B6 (sk) 1993-07-01 1994-06-23 Prostriedok s udržiavaným uvoľňovaním a spôsob jeh
CZ19941550A CZ287918B6 (cs) 1993-07-01 1994-06-23 Orálně podávaná jednotková dávková forma s řízeným uvolňováním a způsob její výroby
NZ260883A NZ260883A (en) 1993-07-01 1994-06-29 Oral sustained-release medicaments containing morphine
AU66105/94A AU6610594A (en) 1991-12-24 1994-06-30 Sustained release compositions and a method of preparing pharmaceutical compositions
FI943141A FI114285B (fi) 1993-07-01 1994-06-30 Menetelmä hitaasti vapauttavan farmaseuttisen annosyksikkömuodon valmistamiseksi
PL94304062A PL179282B1 (pl) 1993-07-01 1994-06-30 Doustny preparat do spowolnionego uwalniania morfinyi sposób wytwarzania multiczastek o spowolnionym uwalnianiu morfiny PL PL PL PL
NO942470A NO306449B1 (no) 1993-07-01 1994-06-30 Oralt administrerbart morfinpreparat for vedvarende frigiving samt fremstilling av multipartikler for bruk i preparatet
CA002127166A CA2127166C (en) 1993-07-01 1994-06-30 Sustained release morphine compositions and a method of preparation
JP15121994A JP3647897B2 (ja) 1993-07-01 1994-07-01 徐放性単位剤形
KR1019940015740A KR100365572B1 (ko) 1993-07-01 1994-07-01 서방성조성물및약학조성물의제조방법
HU9402007A HU220075B (hu) 1993-07-01 1994-07-01 Hosszan tartó hatóanyag-leadású morfintartalmú gyógyszerkészítmények és eljárás ezek előállítására
BG99077A BG62316B1 (bg) 1993-10-07 1994-09-29 фармацевтични форми с постоянно освобождаване и метод за получаването им
BG99078A BG62473B1 (bg) 1993-11-23 1994-09-29 фармацевтичен препарат с контролирано освобождаване
EG61694A EG20600A (en) 1993-10-07 1994-10-03 Sustained release compositions and a method of preparing pharmaceutical compositions
ES94308493T ES2168290T3 (es) 1993-11-23 1994-11-17 Metodo para preparar una composicion de liberacion sostenida.
AT94308493T ATE212224T1 (de) 1993-11-23 1994-11-17 Verfahren zur herstellung einer arzneizusammensetzung mit verzögerter wirkstoffabgabe
DE69429710T DE69429710T2 (de) 1993-11-23 1994-11-17 Verfahren zur Herstellung einer Arzneizusammensetzung mit verzögerter Wirkstoffabgabe
DK94308493T DK0654263T3 (da) 1993-11-23 1994-11-17 Fremgangsmåde til fremstilling af et præparat med langvarig frigivelse
PT94308493T PT654263E (pt) 1993-11-23 1994-11-17 Metodo para a preparacao de uma composicao de libertyacao prolongada
EP94308493A EP0654263B1 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition
NZ264953A NZ264953A (en) 1993-11-23 1994-11-18 Manufacture of drug-containing particles from a mixture of particulate drug and a particulate hydrophobic and/or hydrophilic fusible carrier or diluent in a high speed mixer such that the carrier/diluent melts and breaking up the agglomerates thus formed; sustained release forms
IN1134MA1994 IN179010B (en, 2012) 1993-11-23 1994-11-21
IL11170994A IL111709A (en) 1993-11-23 1994-11-21 Process for the manufacture of sustained release particles and dosage forms comprising particles obtained by the process
BG99198A BG62429B1 (bg) 1993-11-23 1994-11-21 Метод за получаване на фармацевтични състави
CZ19942866A CZ289650B6 (cs) 1993-11-23 1994-11-21 Způsob výroby léčiva, uvolňujícího kontrolovatelně jeho účinnou látku
SK1406-94A SK280496B6 (sk) 1993-11-23 1994-11-22 Spôsob výroby častíc s trvalým uvoľňovaním účinnej
FI945476A FI113335B (fi) 1993-11-23 1994-11-22 Menetelmä farmaseuttisissa koostumuksissa käyttökelpoisten hiukkasten valmistamiseksi
HU9403353A HU217205B (hu) 1993-11-23 1994-11-22 Késleltetett hatóanyag-felszabadítású készítmények és eljárás gyógyszerkészítmények előállítására
NO19944473A NO314124B1 (no) 1993-11-23 1994-11-22 Fremgangsmåte for fremstilling av partikler
EG74294A EG20910A (en) 1993-11-23 1994-11-22 Sustained release compositions and a method of preparing pharmaceutical compositions
PL94305939A PL178883B1 (pl) 1993-11-23 1994-11-22 Sposób wytwarzania cząstek o przedłużonym uwalnianiu,sposób wytwarzania tabletek o przedłużonym uwalnianiu v i sposób wytwarzania twardych kapsułek żelatynowych o przedłużonym uwalnianiu
CN94118503A CN1121213C (zh) 1993-11-23 1994-11-23 缓释组合物的制备方法
ZA949296A ZA949296B (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions.
KR1019940031398A KR100354702B1 (ko) 1993-11-23 1994-11-23 약학조성물의제조방법및서방형조성물
AU79015/94A AU682223C (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions
JP28993694A JP3411114B2 (ja) 1993-11-23 1994-11-24 持効性組成物および薬学的組成物の製造方法
US08/449,772 US6326027B1 (en) 1993-05-10 1995-05-24 Controlled release formulation
US08/607,852 US5849240A (en) 1993-11-23 1996-02-27 Method of preparing sustained release pharmaceutical compositions
US08/607,851 US5891471A (en) 1993-11-23 1996-02-27 Pharmaceutical multiparticulates
IN747MA1996 IN182557B (en, 2012) 1993-11-23 1996-05-06
GR960401422T GR3020084T3 (en) 1993-05-10 1996-05-30 Controlled release formulation containing tramadol.
US08/677,798 US6254887B1 (en) 1993-05-10 1996-07-10 Controlled release tramadol
IL11966096A IL119660A0 (en) 1993-05-10 1996-11-20 Controlled release formulation
US08/843,571 US5879705A (en) 1993-07-27 1997-04-18 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US08/944,106 US5965163A (en) 1993-11-23 1997-09-30 Substained release compositions and a method of preparing pharmaceutical compositions
AU39957/97A AU3995797A (en) 1993-05-10 1997-10-07 Controlled release formulation
AU52995/98A AU722358B2 (en) 1991-12-24 1998-02-06 Sustained release compositions and a method of preparing pharmaceutical compositions
JP22971898A JP3267561B2 (ja) 1993-05-10 1998-08-14 トラマドール又はその薬剤学上許容される塩の使用方法および鎮痛薬剤
US09/264,399 US6143328A (en) 1993-07-27 1999-03-08 Sustained release compositions and a method of preparing pharmaceutical compositions
CNB991066421A CN1146410C (zh) 1993-05-10 1999-05-17 控制释放制剂
NO19993484A NO313124B1 (no) 1993-05-10 1999-07-15 Anvendelse av tramadol i fremstillingen av et medikament for behandling av smerte
US09/370,270 US6162467A (en) 1993-11-23 1999-08-09 Sustained release compositions and a method of preparing pharmaceutical compositions
AT0081699U AT3413U3 (de) 1993-05-10 1999-11-25 Arzneimittel mit kontrollierter freisetzung von tramadol
US09/740,732 US20010019725A1 (en) 1993-11-23 2000-12-19 Sustained release compositions and a method of preparing pharmaceutical compositions
US09/800,204 US7074430B2 (en) 1993-05-10 2001-03-06 Controlled release tramadol tramadol formulation
NO20013566A NO331650B1 (no) 1993-05-10 2001-07-19 Oralt preparat av tramadol eller et farmasoytisk akseptabelt salt derav med regulert frigjoringsvirkning
GR20010401419T GR3036565T3 (en) 1993-05-10 2001-09-06 Controlled release formulation
JP2001297270A JP3443574B2 (ja) 1993-05-10 2001-09-27 トラマドール又はその塩を含む鎮痛剤
JP2002271157A JP2003113075A (ja) 1993-11-23 2002-09-18 持効性組成物
FI20030560A FI121565B (fi) 1993-05-10 2003-04-14 Menetelmä hallitusti tramadolia vapauttavan valmisteen valmistamiseksi
US11/435,015 US20060269603A1 (en) 1993-05-10 2006-05-16 Controlled release tramadol formulations
US12/152,474 US20090117191A1 (en) 1993-05-10 2008-05-14 Controlled release tramadol formulations
FI20105856A FI122717B (fi) 1993-05-10 2010-08-17 Menetelmä valmistaa tramadolihydrokloridia hallitusti vapauttava valmiste

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US5849240A (en) 1993-11-23 1998-12-15 Euro-Celtique, S.A. Method of preparing sustained release pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5958452A (en) 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US6068855A (en) 1994-11-03 2000-05-30 Euro-Celtique S. A. Pharmaceutical composition containing a fusible carrier and method for producing the same
US7829120B2 (en) 2005-09-09 2010-11-09 Labopharm Inc. Trazodone composition for once a day administration
US7988998B2 (en) 2002-10-25 2011-08-02 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
US8414919B2 (en) 2005-09-09 2013-04-09 Angelini Labopharm, Llc Sustained drug release composition
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions

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US5849240A (en) 1993-11-23 1998-12-15 Euro-Celtique, S.A. Method of preparing sustained release pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US6162467A (en) 1993-11-23 2000-12-19 Euro-Celtique, S.A. Sustained release compositions and a method of preparing pharmaceutical compositions
US5965163A (en) 1993-11-23 1999-10-12 Euro-Celtique, S.A. Substained release compositions and a method of preparing pharmaceutical compositions
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
US6068855A (en) 1994-11-03 2000-05-30 Euro-Celtique S. A. Pharmaceutical composition containing a fusible carrier and method for producing the same
US6261599B1 (en) 1994-11-04 2001-07-17 Euro-Celtique, S.A. Melt-extruded orally administrable opioid formulations
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5958452A (en) 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US6335033B2 (en) 1994-11-04 2002-01-01 Euro-Celtique, S.A. Melt-extrusion multiparticulates
US6706281B2 (en) 1994-11-04 2004-03-16 Euro-Celtique, S.A. Melt-extrusion multiparticulates
US7988998B2 (en) 2002-10-25 2011-08-02 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US7829120B2 (en) 2005-09-09 2010-11-09 Labopharm Inc. Trazodone composition for once a day administration
US8414919B2 (en) 2005-09-09 2013-04-09 Angelini Labopharm, Llc Sustained drug release composition
US8795723B2 (en) 2005-09-09 2014-08-05 Angelini Pharma Inc. Sustained drug release compositions
US8962019B2 (en) 2005-09-09 2015-02-24 Angelini Pharma, Inc. Sustained drug release composition
US9439866B2 (en) 2005-09-09 2016-09-13 Angelini Pharma, Inc. Trazodone composition for once a day administration

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