GB1526331A - Phthalanes - Google Patents

Phthalanes

Info

Publication number
GB1526331A
GB1526331A GB1486/76A GB148676A GB1526331A GB 1526331 A GB1526331 A GB 1526331A GB 1486/76 A GB1486/76 A GB 1486/76A GB 148676 A GB148676 A GB 148676A GB 1526331 A GB1526331 A GB 1526331A
Authority
GB
United Kingdom
Prior art keywords
jan
phthalanes
kefalas
alkanoyl
heading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1486/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
Kefalas AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9722860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1526331(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB1486/76A priority Critical patent/GB1526331A/en
Application filed by Kefalas AS filed Critical Kefalas AS
Priority to DE2657013A priority patent/DE2657013C2/de
Priority to SE7614201A priority patent/SE429551B/xx
Priority to AT947276A priority patent/AT359488B/de
Priority to IE5/77A priority patent/IE44055B1/en
Priority to ZA770057A priority patent/ZA7757B/xx
Priority to AU21073/77A priority patent/AU509445B2/en
Priority to NZ183001A priority patent/NZ183001A/en
Priority to US05/757,619 priority patent/US4136193A/en
Priority to FI770073A priority patent/FI63754C/fi
Priority to ES454980A priority patent/ES454980A1/es
Priority to NL7700244A priority patent/NL192451C/nl
Priority to CH42377A priority patent/CH626886A5/de
Priority to JP199777A priority patent/JPS52105162A/ja
Priority to CA000269610A priority patent/CA1094087A/en
Priority to NO770109A priority patent/NO147243C/no
Priority to BE174098A priority patent/BE850401A/xx
Priority to DK13177A priority patent/DK143275C/da
Priority to FR7701079A priority patent/FR2338271A1/fr
Publication of GB1526331A publication Critical patent/GB1526331A/en
Priority to AT571979A priority patent/AT360001B/de
Priority to AT572079A priority patent/AT360002B/de
Priority to CH357481A priority patent/CH632258A5/de
Priority to CH357581A priority patent/CH632259A5/de
Priority to NO1996001C priority patent/NO1996001I1/no
Priority to NL970031C priority patent/NL970031I2/nl
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB1486/76A 1976-01-14 1976-01-14 Phthalanes Expired GB1526331A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes
DE2657013A DE2657013C2 (de) 1976-01-14 1976-12-16 1-(3-Dimethylaminopropyl)-phthalane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE7614201A SE429551B (sv) 1976-01-14 1976-12-17 Sett att framstella 1-(3-dimetylamino-propyl)-ftalanderivat
AT947276A AT359488B (de) 1976-01-14 1976-12-21 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch annehm- baren saeureadditionssalzen
IE5/77A IE44055B1 (en) 1976-01-14 1977-01-04 Phthalanes
ZA770057A ZA7757B (en) 1976-01-14 1977-01-05 Organic compounds
AU21073/77A AU509445B2 (en) 1976-01-14 1977-01-05 Phathalanes
NZ183001A NZ183001A (en) 1976-01-14 1977-01-06 3-dimethylamin opropyl-3-phenyl-benzo(c)furans,and pharmaceutical compositions
US05/757,619 US4136193A (en) 1976-01-14 1977-01-07 Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
FI770073A FI63754C (fi) 1976-01-14 1977-01-11 Foerfarande foer framstaellning av en terapeutiskt anvaendbar ftalan
ES454980A ES454980A1 (es) 1976-01-14 1977-01-12 Metodo para preparar un ftalano.
NL7700244A NL192451C (nl) 1976-01-14 1977-01-12 Werkwijze voor de bereiding van ftalanderivaten en werkwijze voor de bereiding van farmaceutische preparaten die een ftalanderivaat bevatten.
CA000269610A CA1094087A (en) 1976-01-14 1977-01-13 Phthalane derivatives, compositions thereof and a method of preparation thereof
CH42377A CH626886A5 (https=) 1976-01-14 1977-01-13
NO770109A NO147243C (no) 1976-01-14 1977-01-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalanderivater
JP199777A JPS52105162A (en) 1976-01-14 1977-01-13 Phthleic derivatives and preparation thereof
BE174098A BE850401A (fr) 1976-01-14 1977-01-14 Derives de phtalane et procede de preparation
DK13177A DK143275C (da) 1976-01-14 1977-01-14 Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
FR7701079A FR2338271A1 (fr) 1976-01-14 1977-01-14 Derives du phtalane, procede pour leur preparation, et compositions pharmaceutiques contenant de tels derives
AT572079A AT360002B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
AT571979A AT360001B (de) 1976-01-14 1979-08-27 Verfahren zur herstellung von neuen phthalan- -derivaten und ihren pharmazeutisch ver- traeglichen saeureadditionssalzen
CH357581A CH632259A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
CH357481A CH632258A5 (de) 1976-01-14 1981-06-01 Verfahren zur herstellung von neuen phthalanen.
NO1996001C NO1996001I1 (no) 1976-01-14 1996-01-05 Citalopram
NL970031C NL970031I2 (nl) 1976-01-14 1997-08-04 Werkwijze voor de bereiding van ftalanderivaten enwerkwijze voor de bereiding van farmaceutische pr eparaten die een ftalanderivaat bevatten.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Publications (1)

Publication Number Publication Date
GB1526331A true GB1526331A (en) 1978-09-27

Family

ID=9722860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1486/76A Expired GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Country Status (19)

Country Link
US (1) US4136193A (https=)
JP (1) JPS52105162A (https=)
AT (1) AT359488B (https=)
AU (1) AU509445B2 (https=)
BE (1) BE850401A (https=)
CA (1) CA1094087A (https=)
CH (3) CH626886A5 (https=)
DE (1) DE2657013C2 (https=)
DK (1) DK143275C (https=)
ES (1) ES454980A1 (https=)
FI (1) FI63754C (https=)
FR (1) FR2338271A1 (https=)
GB (1) GB1526331A (https=)
IE (1) IE44055B1 (https=)
NL (2) NL192451C (https=)
NO (2) NO147243C (https=)
NZ (1) NZ183001A (https=)
SE (1) SE429551B (https=)
ZA (1) ZA7757B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
WO2001002383A3 (en) * 1999-07-06 2001-05-03 Vis Farmaceutici S P A Process for the synthesis of citalopram
WO2002070501A1 (en) * 2001-03-07 2002-09-12 Cipla Ltd. Preparation of phthalanes
EP1265883A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
WO2003072563A1 (en) * 2002-02-27 2003-09-04 Cipla Ltd. Amorphous citalopram salts
US7002025B2 (en) 2000-03-07 2006-02-21 Resolution Chemicals Limited Process for the preparation of citalopram

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
ATE192042T1 (de) * 1995-08-16 2000-05-15 Lilly Co Eli Potenzierung von serotonin-wirkstoffresponz
WO1998019513A2 (en) 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (en) 1997-11-11 2002-07-31 H. Lundbeck A/S Method for the preparation of citalopram
CA2291134C (en) 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
AR021509A1 (es) * 1998-12-08 2002-07-24 Lundbeck & Co As H Derivados de benzofurano, su preparacion y uso
HRP20010418A2 (en) 1998-12-08 2002-06-30 Lundbeck & Co As H Benzofuran derivatives, their preparation and use
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) * 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
EA004742B1 (ru) * 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
BR9917604A (pt) * 1999-12-30 2002-12-31 Lundbeck & Co As H Método para preparação de citalopram
HUP0300343A2 (hu) * 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
KR100821912B1 (ko) * 2000-05-12 2008-04-16 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CZ2002832A3 (cs) * 2000-07-06 2002-05-15 H. Lundbeck A/S Způsob výroby citalopramu
WO2002008216A1 (en) * 2000-07-21 2002-01-31 H. Lundbeck A/S Novel compounds and their use as glycine transport inhibitors
IES20010693A2 (en) * 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
CA2354877C (en) * 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
NL1017525C1 (nl) * 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
DE10164725B4 (de) * 2000-12-28 2004-08-26 H. Lundbeck A/S Verfahren zur Herstellung von gereinigtem Citalopram
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
ATE222899T1 (de) * 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
EP1355897A1 (en) * 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
WO2002066453A1 (en) * 2001-02-22 2002-08-29 Natco Pharma Limited Process for the preparation of citalopram
WO2002072565A1 (en) * 2001-03-09 2002-09-19 Ranbaxy Laboratories Limited Process for the preparation of citalopram
EA200301195A1 (ru) * 2001-05-01 2004-04-29 Х. Лундбекк А/С Применение энантиомерно чистого эсциталопрама
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IN192057B (https=) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
BR0206164A (pt) 2001-07-31 2003-10-28 Lundbeck & Co As H Partìculas cristalinas de oxalato de escitalopram, método para a produção de partìculas cristalinas de oxalato de escitalopram, e, forma de dosagem unitária sólida
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
ES2666188T3 (es) * 2001-10-12 2018-05-03 Azevan Pharmaceuticals, Inc. Antagonistas del v1a de vasopresina beta-lactámicos
IN192863B (https=) * 2001-11-13 2004-05-22 Ranbaxy Lab Ltd
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
WO2003080558A1 (en) * 2002-03-27 2003-10-02 Bando Chemical Industries, Ltd. Novel 1,3,5-tris(arylamino)benzene
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
AU2002330730A1 (en) * 2002-08-14 2004-03-03 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
UA80170C2 (en) * 2002-12-23 2007-08-27 Lundbeck & Co As H Escitalopram hydrobromide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
KR20060040676A (ko) * 2003-07-11 2006-05-10 미리어드 제네틱스, 인크. 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
ITFI20030202A1 (it) * 2003-07-28 2005-01-29 Synteco Spa Processo per la preparazione di derivati del
SI1668014T1 (sl) * 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
ES2240931T3 (es) * 2003-10-28 2005-10-16 Adorkem Technology Spa Procedimiento para la preparacion de citalopram.
WO2005042473A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CA2547639A1 (en) * 2003-12-02 2005-06-16 B&B Beheer Nv Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists
US20050176680A1 (en) 2003-12-11 2005-08-11 Sepracor, Inc. Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2005077927A1 (en) * 2004-02-16 2005-08-25 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
WO2005102366A2 (en) * 2004-04-19 2005-11-03 Philip Maxwell Satow Lithium combinations, and uses related thereto
AU2005241023A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020853A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
US7790935B2 (en) 2004-08-23 2010-09-07 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
AU2006227199A1 (en) 2005-03-22 2006-09-28 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
WO2006103550A1 (en) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processes for the preparation of citalopram and its intermediate 5-aminophthalide
CN101203218A (zh) 2005-04-22 2008-06-18 惠氏公司 苯并呋喃基链烷胺衍生物和其作为5－ht2c激动剂的用途
MX2007012883A (es) 2005-04-22 2007-12-10 Wyeth Corp Derivados de dihidrobenzofurano y usos de los mismos.
AR055054A1 (es) * 2005-04-22 2007-08-01 Wyeth Corp Cristales formados de clorhidrato de (((2r)-7-(2,6-diclorofenil)-5-fluoro-2,3- dihidro-1-benzofurano-2-il) metil ) amina
AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
AU2006269231A1 (en) 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
US20070015832A1 (en) * 2005-07-14 2007-01-18 Myriad Genetics, Incorporated Methods of treating overactive bladder and urinary incontinence
KR101523776B1 (ko) * 2005-07-19 2015-05-28 아제반 파마슈티칼스, 인코퍼레이티드 베타-락타민 페닐알라닌, 시스테인 그리고 세린 바소프레신길항물질
KR20080039876A (ko) * 2005-07-22 2008-05-07 미리어드 제네틱스, 인크. 높은 약물 충진 제형 및 투여형
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CN101309924A (zh) * 2005-11-14 2008-11-19 H.隆德贝克有限公司 依地普仑的制备方法
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
FR2912057B1 (fr) * 2007-02-07 2009-04-17 Sanofi Aventis Sa Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
KR20080105104A (ko) * 2006-03-24 2008-12-03 와이어쓰 우울증 치료를 위한 신규한 치료학적 병용제
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2046119A2 (en) * 2006-07-07 2009-04-15 Myriad Genetics, Inc. Treatment of psychiatric disorders
TW200817003A (en) * 2006-07-31 2008-04-16 Sanofi Aventis Pharmaceutical composition comprising, in combination, saredutant and a selective serotonin peuptake inhibitor or a serotonin/norepinephrine reuptake inhibitor
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2008034032A2 (en) * 2006-09-14 2008-03-20 Azevan Pharmaceuticals, Inc. Beta-lactam cannabinoid receptor modulators
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
JP4927497B2 (ja) * 2006-10-25 2012-05-09 株式会社シスコ 無湿乾燥用ホッパー装置
CN100457747C (zh) * 2006-11-21 2009-02-04 浙江大学 抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
US20080171750A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation Of Neurogenesis With Use of Modafinil
PT1988086E (pt) 2007-04-23 2012-02-28 Synthon Bv Processo para a resolução de citalopram via o seu composto tartarato de citalopram enriquecido em (s)
NZ580738A (en) * 2007-05-18 2012-02-24 Cipla Ltd Process for the preparation of escitalopram
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
KR101103118B1 (ko) * 2007-11-02 2012-01-04 동아제약주식회사 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물
WO2009128058A1 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
EP2116231A1 (en) 2008-05-07 2009-11-11 Hexal Ag Granulate comprising escitalopram oxalate
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
GR20080100696A (el) 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
WO2012003436A1 (en) 2010-07-01 2012-01-05 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
WO2013081567A1 (en) 2011-12-02 2013-06-06 Mahmut Bilgic Effervescent antipsychotic formulations
WO2013100870A1 (en) 2011-12-02 2013-07-04 Mahmut Bilgic New antipsychotic compositions
WO2013110313A1 (en) * 2012-01-23 2013-08-01 H. Lundbeck A/S Selective allosteric modulators of the serotonin transporter
NZ724718A (en) 2014-03-28 2023-04-28 Azevan Pharmaceuticals Inc Compositions and methods for treating neurodegenerative diseases
US10828302B2 (en) 2016-03-10 2020-11-10 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
WO2019055913A1 (en) 2017-09-15 2019-03-21 Azevan Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF BRAIN INJURY
EP3999058A4 (en) 2019-07-19 2023-05-03 Bioxcel Therapeutics, Inc. NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (https=) * 1965-03-18

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
WO2001002383A3 (en) * 1999-07-06 2001-05-03 Vis Farmaceutici S P A Process for the synthesis of citalopram
US7002025B2 (en) 2000-03-07 2006-02-21 Resolution Chemicals Limited Process for the preparation of citalopram
EP1265883A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
WO2002070501A1 (en) * 2001-03-07 2002-09-12 Cipla Ltd. Preparation of phthalanes
LT5167B (lt) 2001-03-07 2004-10-25 Cipla Ltd. Ftalanų gavimas
US6903228B2 (en) * 2001-03-07 2005-06-07 Cipla Limited Preparation of phthalanes
RU2276148C2 (ru) * 2001-03-07 2006-05-10 Сипла Лтд. Способ получения фталанов
WO2003072563A1 (en) * 2002-02-27 2003-09-04 Cipla Ltd. Amorphous citalopram salts

Also Published As

Publication number Publication date
BE850401A (fr) 1977-07-14
DE2657013A1 (de) 1977-07-28
IE44055B1 (en) 1981-07-29
DK143275B (da) 1981-08-03
NO1996001I1 (no) 1996-01-05
NZ183001A (en) 1978-06-02
US4136193A (en) 1979-01-23
AT359488B (de) 1980-11-10
FI770073A7 (https=) 1977-07-15
ES454980A1 (es) 1978-04-01
ZA7757B (en) 1977-11-30
NO147243B (no) 1982-11-22
CH626886A5 (https=) 1981-12-15
ATA947276A (de) 1980-04-15
JPS6135986B2 (https=) 1986-08-15
FI63754C (fi) 1983-08-10
NL192451C (nl) 1997-08-04
NO770109L (no) 1977-07-15
CH632259A5 (de) 1982-09-30
FR2338271A1 (fr) 1977-08-12
DK143275C (da) 1982-01-18
FI63754B (fi) 1983-04-29
DK13177A (da) 1977-07-15
SE7614201L (sv) 1977-07-15
NL7700244A (nl) 1977-07-18
FR2338271B1 (https=) 1982-11-05
JPS52105162A (en) 1977-09-03
DE2657013C2 (de) 1985-11-14
AU2107377A (en) 1978-07-13
AU509445B2 (en) 1980-05-15
NL192451B (nl) 1997-04-01
NL970031I1 (nl) 1997-10-01
CH632258A5 (de) 1982-09-30
NO147243C (no) 1983-03-02
CA1094087A (en) 1981-01-20
NL970031I2 (nl) 1997-10-01
SE429551B (sv) 1983-09-12
IE44055L (en) 1977-07-14

Similar Documents

Publication Publication Date Title
GB1526331A (en) Phthalanes
GB1527562A (en) Substituted-methyl-11-cyano-9,10-dihydroethanoanthracene-11-carboxylates useful as intermediates
GB1496766A (en) 5-substituted-alkyl-8-hydroxycarbostyril derivatives and production thereof
ES8609204A1 (es) Procedimiento de preparar derivados aminicos
GB1435573A (en) Indoloquinolizines
GB1513320A (en) N-propargyl-2-phenylamino-2-imidazolines
GB1443503A (en) Salt of 5-substituted-2-furamidines and their preparation
GB1325386A (en) Quinazoline derivatives processes for producing them and compositions containing them
GB1492718A (en) Benzothiazine 1,1-dioxide derivatives
GB1409648A (en) Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof
GB1490486A (en) 4-imino-1,3-diazobicyclo-(3.1.0)hexan-2-one
GB1457038A (en) Amino derivatives of 1,4-benzodioxan
GB1436307A (en) Diaromatic o-aminoalkyl-oximes
GB1394619A (en) Imides
GB1443692A (en) 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof
GB1448781A (en) N- omega-amino- alkylaniline compounds
GB1449387A (en) Benzylpyrimidine derivatives
GB1503447A (en) Dl-and 8r-9-fluoro-prostadienoic acid derivatives and process
GB1473971A (en) 3-hydroxy-5,6-benzomorphinan derivatives
GB1325770A (en) Pyrimidopyridazine derivatives
GB1531041A (en) Substituted haloacetophenone oximes
GB1412932A (en) Pharmaceutically active leurosine derivatives and preparation thereof
GB1472344A (en) Methylene dibenzocycloheptanes
SE7408868L (https=)
GB1471902A (en) Styrylsulphonylamidines

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB95/024, 950731

CTFG Supplementary protection certificate granted

Free format text: SPC/GB95/024, 960131, EXPIRES:20020105

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB95/024, 970106, EXPIRES:20020105

PE20 Patent expired after termination of 20 years

Effective date: 19970105

SPCE Supplementary protection certificate expired

Free format text: SPC/GB95/024: 20020105