HRP20020344B1 - Način priprave citaloprama - Google Patents

Način priprave citaloprama

Info

Publication number
HRP20020344B1
HRP20020344B1 HR20020344A HRP20020344A HRP20020344B1 HR P20020344 B1 HRP20020344 B1 HR P20020344B1 HR 20020344 A HR20020344 A HR 20020344A HR P20020344 A HRP20020344 A HR P20020344A HR P20020344 B1 HRP20020344 B1 HR P20020344B1
Authority
HR
Croatia
Prior art keywords
citalopram
preparation
dimethylamino
acyl
reacting
Prior art date
Application number
HR20020344A
Other languages
English (en)
Inventor
Harold Rock Michael
Petersen Hans
Ellegaard Peter
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20020344A2 publication Critical patent/HRP20020344A2/hr
Publication of HRP20020344B1 publication Critical patent/HRP20020344B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Postupak pripreme citaloprama, naznačen time, da sadrži reakciju spoja formule IVpri čemu R označava acil, s 3 - (N,N - dimetilamino) propil magnezijevim halidom, kako bi se dobio citalopramkoji se izolira kao baza ili njezina farmaceutski prihvatljiva sol. Patent sadrži još 9 patentnih zahtjeva.
HR20020344A 1999-10-25 2002-04-19 Način priprave citaloprama HRP20020344B1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
HRP20020344A2 HRP20020344A2 (en) 2004-02-29
HRP20020344B1 true HRP20020344B1 (hr) 2010-10-31

Family

ID=8157164

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020344A HRP20020344B1 (hr) 1999-10-25 2002-04-19 Način priprave citaloprama

Country Status (25)

Country Link
US (1) US6566540B2 (hr)
EP (1) EP1298124B1 (hr)
KR (1) KR100505820B1 (hr)
AR (1) AR024518A1 (hr)
AT (2) ATE355268T1 (hr)
CA (1) CA2291133C (hr)
CY (1) CY1107635T1 (hr)
CZ (1) CZ292894B6 (hr)
DE (3) DE69935355T2 (hr)
DK (2) DK1228056T3 (hr)
EA (1) EA002801B1 (hr)
ES (1) ES2282365T3 (hr)
HK (1) HK1043129B (hr)
HR (1) HRP20020344B1 (hr)
HU (1) HUP0200169A3 (hr)
IL (3) IL143875A0 (hr)
IS (1) IS2260B (hr)
NO (1) NO20071311L (hr)
NZ (1) NZ512406A (hr)
PL (1) PL201056B1 (hr)
PT (2) PT1228056E (hr)
SI (2) SI1298124T1 (hr)
SK (1) SK287140B6 (hr)
TR (1) TR200401456T1 (hr)
UA (1) UA72238C2 (hr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
CN100349885C (zh) * 2002-12-23 2007-11-21 H·隆德贝克有限公司 依他普仑氢溴酸盐及其制备方法
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2009511607A (ja) * 2005-10-14 2009-03-19 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムおよびブプロピオンを含有する安定な医薬製剤
EP1954257A4 (en) * 2005-10-14 2009-05-20 Lundbeck & Co As H METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION
NO2185155T3 (hr) * 2007-08-03 2018-03-03

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (hr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE69801764T2 (de) 1997-07-08 2002-07-04 Lundbeck & Co As H Verfahren zur herstellung von citalopram
DE69714480T2 (de) * 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
JP2002533450A (ja) 1998-12-23 2002-10-08 ハー・ルンドベック・アクチエゼルスカベット ５−シアノフタリドの製造方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
DE19983836C1 (de) 2003-10-23
DK1298124T3 (da) 2007-07-09
SI1298124T1 (sl) 2007-08-31
SK287140B6 (sk) 2010-01-07
US6566540B2 (en) 2003-05-20
PL349440A1 (en) 2002-07-29
IL176943A0 (en) 2006-12-10
EP1298124B1 (en) 2007-02-28
CA2291133A1 (en) 2001-04-25
UA72238C2 (en) 2005-02-15
NZ512406A (en) 2004-01-30
ES2282365T3 (es) 2007-10-16
HRP20020344A2 (en) 2004-02-29
IL143875A0 (en) 2002-04-21
HK1043129B (zh) 2004-10-21
DE69920526D1 (de) 2004-10-28
PT1298124E (pt) 2007-05-31
EA200100593A1 (ru) 2001-10-22
US20020177722A1 (en) 2002-11-28
PT1228056E (pt) 2005-02-28
EA002801B1 (ru) 2002-10-31
TR200401456T1 (tr) 2005-04-21
CY1107635T1 (el) 2013-04-18
IL143875A (en) 2008-03-20
AR024518A1 (es) 2002-10-16
NO20071311L (no) 2001-08-24
ATE277032T1 (de) 2004-10-15
HUP0200169A3 (en) 2002-11-28
HK1043129A1 (en) 2002-09-06
KR20010092799A (ko) 2001-10-27
CZ292894B6 (cs) 2003-12-17
DE69935355T2 (de) 2007-11-08
KR100505820B1 (ko) 2005-08-03
HUP0200169A2 (en) 2002-06-29
IS2260B (is) 2007-06-15
ATE355268T1 (de) 2006-03-15
IS5970A (is) 2001-06-15
DE69920526T2 (de) 2006-02-23
CA2291133C (en) 2003-06-17
EP1298124A1 (en) 2003-04-02
DE69935355D1 (de) 2007-04-12
DK1228056T3 (da) 2005-01-24
PL201056B1 (pl) 2009-03-31
SI1228056T1 (en) 2005-02-28

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Payment date: 20111022

Year of fee payment: 13

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Effective date: 20121026