FR2470132A1 - 1-oxo-1h-thiazolo-(3,2-a)-pyrimidine-2-carboxamides, anti-allergiques et anti-ulcereux, medicament les contenant et composes intermediaires permettant de les obtenir - Google Patents

1-oxo-1h-thiazolo-(3,2-a)-pyrimidine-2-carboxamides, anti-allergiques et anti-ulcereux, medicament les contenant et composes intermediaires permettant de les obtenir Download PDF

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Publication number
FR2470132A1
FR2470132A1 FR8024822A FR8024822A FR2470132A1 FR 2470132 A1 FR2470132 A1 FR 2470132A1 FR 8024822 A FR8024822 A FR 8024822A FR 8024822 A FR8024822 A FR 8024822A FR 2470132 A1 FR2470132 A1 FR 2470132A1
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FR
France
Prior art keywords
oxo
pyrimidine
ethyl
group
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8024822A
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English (en)
French (fr)
Other versions
FR2470132B1 (sv
Inventor
Saul Bernard Kadin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2470132A1 publication Critical patent/FR2470132A1/fr
Application granted granted Critical
Publication of FR2470132B1 publication Critical patent/FR2470132B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
FR8024822A 1979-11-23 1980-11-21 1-oxo-1h-thiazolo-(3,2-a)-pyrimidine-2-carboxamides, anti-allergiques et anti-ulcereux, medicament les contenant et composes intermediaires permettant de les obtenir Granted FR2470132A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9663179A 1979-11-23 1979-11-23

Publications (2)

Publication Number Publication Date
FR2470132A1 true FR2470132A1 (fr) 1981-05-29
FR2470132B1 FR2470132B1 (sv) 1983-07-29

Family

ID=22258306

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8024822A Granted FR2470132A1 (fr) 1979-11-23 1980-11-21 1-oxo-1h-thiazolo-(3,2-a)-pyrimidine-2-carboxamides, anti-allergiques et anti-ulcereux, medicament les contenant et composes intermediaires permettant de les obtenir

Country Status (35)

Country Link
JP (1) JPS5687586A (sv)
KR (1) KR830004322A (sv)
AR (2) AR228859A1 (sv)
AT (1) AT380883B (sv)
AU (1) AU520995B2 (sv)
BE (1) BE886319A (sv)
CA (1) CA1143731A (sv)
CH (1) CH649299A5 (sv)
CS (1) CS241476B2 (sv)
DD (1) DD154608A5 (sv)
DE (2) DE3050491C2 (sv)
DK (1) DK151811C (sv)
EG (1) EG14929A (sv)
ES (1) ES8203363A1 (sv)
FI (1) FI67706C (sv)
FR (1) FR2470132A1 (sv)
GB (1) GB2063862B (sv)
GR (1) GR72132B (sv)
GT (1) GT198066458A (sv)
HU (1) HU179091B (sv)
IE (1) IE50404B1 (sv)
IL (1) IL61535A (sv)
IN (1) IN154926B (sv)
IT (1) IT1209373B (sv)
LU (1) LU82950A1 (sv)
NL (1) NL182565C (sv)
NO (1) NO803521L (sv)
NZ (1) NZ195596A (sv)
PH (1) PH16666A (sv)
PL (1) PL132354B1 (sv)
PT (1) PT72090B (sv)
SE (1) SE448732B (sv)
SU (1) SU1042620A3 (sv)
YU (1) YU41953B (sv)
ZA (1) ZA807293B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
GB8422916D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
JP2690742B2 (ja) * 1987-03-30 1997-12-17 第一製薬株式会社 複素環アミン誘導体
ES2087072T3 (es) * 1988-03-28 1996-07-16 Janssen Pharmaceutica Nv Agentes para conservar o restablecer la salud de la piel.
TWI500623B (zh) * 2009-10-13 2015-09-21 Torrent Pharmaceuticals Ltd 新穎稠合噻唑及噁唑嘧啶酮

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1331059A (en) 1971-04-19 1973-09-19 Lilly Industries Ltd Pyrimidotriazinone compounds
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
DE2810863A1 (de) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-oxo-1h-pyrimido eckige klammer auf 6,1-b eckige klammer zu benzthiazol-derivate und verfahren zu ihrer herstellung
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones

Also Published As

Publication number Publication date
JPS5687586A (en) 1981-07-16
GB2063862B (en) 1983-06-22
DE3043979A1 (de) 1981-09-03
PL228008A1 (sv) 1981-12-11
HU179091B (en) 1982-08-28
NL182565C (nl) 1988-04-05
SE448732B (sv) 1987-03-16
DK151811B (da) 1988-01-04
NL8006362A (nl) 1981-06-16
AR228859A1 (es) 1983-04-29
ATA570780A (de) 1985-12-15
CH649299A5 (fr) 1985-05-15
ES497066A0 (es) 1982-04-01
CS782080A2 (en) 1985-06-13
YU295080A (en) 1983-06-30
IL61535A0 (en) 1980-12-31
FI803628L (fi) 1981-05-24
SE8008189L (sv) 1981-05-24
FI67706B (fi) 1985-01-31
FR2470132B1 (sv) 1983-07-29
GB2063862A (en) 1981-06-10
AR231296A1 (es) 1984-10-31
BE886319A (fr) 1981-05-25
NO803521L (no) 1981-05-25
PT72090A (en) 1980-12-01
DD154608A5 (de) 1982-04-07
GT198066458A (es) 1982-05-15
PL132354B1 (en) 1985-02-28
JPS617432B2 (sv) 1986-03-06
IL61535A (en) 1984-06-29
EG14929A (en) 1989-01-30
NL182565B (nl) 1987-11-02
IN154926B (sv) 1984-12-22
DK151811C (da) 1988-06-06
AT380883B (de) 1986-07-25
CS241476B2 (en) 1986-03-13
PT72090B (en) 1981-09-29
SU1042620A3 (ru) 1983-09-15
KR830004322A (ko) 1983-07-09
IE802418L (en) 1981-05-23
DK413180A (da) 1981-05-24
DE3043979C2 (de) 1986-08-21
FI67706C (fi) 1985-05-10
ES8203363A1 (es) 1982-04-01
IT1209373B (it) 1989-07-16
CA1143731A (en) 1983-03-29
GR72132B (sv) 1983-09-19
IT8026176A0 (it) 1980-11-21
DE3050491C2 (de) 1985-10-10
NZ195596A (en) 1984-05-31
AU520995B2 (en) 1982-03-11
IE50404B1 (en) 1986-04-16
PH16666A (en) 1983-12-13
LU82950A1 (fr) 1981-06-04
AU6459580A (en) 1981-05-28
ZA807293B (en) 1981-12-30
YU41953B (en) 1988-02-29

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