FR2390159A1 - Liposomes et procedes pour les produire - Google Patents

Liposomes et procedes pour les produire

Info

Publication number
FR2390159A1
FR2390159A1 FR7813632A FR7813632A FR2390159A1 FR 2390159 A1 FR2390159 A1 FR 2390159A1 FR 7813632 A FR7813632 A FR 7813632A FR 7813632 A FR7813632 A FR 7813632A FR 2390159 A1 FR2390159 A1 FR 2390159A1
Authority
FR
France
Prior art keywords
liposomes
lyophilized
active compound
biologically active
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7813632A
Other languages
English (en)
Other versions
FR2390159B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2390159A1 publication Critical patent/FR2390159A1/fr
Application granted granted Critical
Publication of FR2390159B1 publication Critical patent/FR2390159B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne l'industrie pharmaceutique. Elle a pour objet un procédé pour préparer un mélange lyophilisé de liposomes potentiels, suivant lequel soit a on dissout au moins un lipide amphipathique formant des liposomes, au moins un composé biologiquement actif et éventuellement un ou plusieurs adjuvants dans un solvant convenable et on lyophilise la solution, soit b on prépare de manière classique une composition aqueuse de liposomes contenant au moins un composé biologiquement actif et on lyophilise la composition aqueuse, ainsi qu'un procédé pour préparer une préparation aqueuse de liposomes par dispersion du mélange lyophilisé obtenu ci-dessus dans un milieu aqueux convenable. Le procédé est préféré pour la production de liposomes contenant un composé biologiquement actif hydrosoluble qui ne s'associe pas aux lipides ainsi que pour des composés solubles dans les lipides ou s'associant à ceux-ci.
FR7813632A 1977-05-10 1978-05-09 Liposomes et procedes pour les produire Granted FR2390159A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19510/77A GB1575343A (en) 1977-05-10 1977-05-10 Method for preparing liposome compositions containing biologically active compounds

Publications (2)

Publication Number Publication Date
FR2390159A1 true FR2390159A1 (fr) 1978-12-08
FR2390159B1 FR2390159B1 (fr) 1983-01-14

Family

ID=10130587

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7813632A Granted FR2390159A1 (fr) 1977-05-10 1978-05-09 Liposomes et procedes pour les produire

Country Status (19)

Country Link
US (2) US4311712A (fr)
JP (1) JPS53142514A (fr)
AU (1) AU514644B2 (fr)
BE (1) BE866697A (fr)
CA (1) CA1114758A (fr)
CH (2) CH650944A5 (fr)
DE (1) DE2818655C2 (fr)
DK (2) DK156765C (fr)
FI (1) FI63856C (fr)
FR (1) FR2390159A1 (fr)
GB (1) GB1575343A (fr)
IE (1) IE46571B1 (fr)
IL (2) IL54270A (fr)
IT (1) IT1094811B (fr)
NL (1) NL7805005A (fr)
NO (3) NO150184C (fr)
NZ (1) NZ186696A (fr)
SE (3) SE440725B (fr)
ZA (1) ZA781416B (fr)

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FR2441385A1 (fr) * 1978-11-17 1980-06-13 Serono Ist Farm Procede de preparation extemporanee de liposomes et liposomes ainsi obtenus
FR2446635A1 (fr) * 1979-01-19 1980-08-14 Erba Farmitalia Compositions pharmaceutiques consistant en liposomes et procede pour les preparer
FR2455458A1 (fr) * 1979-05-02 1980-11-28 Kureha Chemical Ind Co Ltd Liposomes contenant une substance active, notamment un principe actif de medicament
EP0028917A2 (fr) * 1979-11-08 1981-05-20 Merck & Co. Inc. Vésicules lipidiques porteuses de surfaces carbohydratées et utilisées comme véhicules à action directe sur la lymphe pour des substances thérapeutiques et de diagnostic, leur utilisation et procédé pour leur préparation
FR2472386A1 (fr) * 1979-12-27 1981-07-03 Human Oltoanyagtermelo
EP0161445A1 (fr) * 1984-03-31 1985-11-21 Green Cross Corporation Complexe hydrosoluble d'un médicament et procédé pour sa préparation
DE3713493A1 (de) * 1986-04-22 1987-10-29 Oreal Kosmetisches oder pharmazeutisches mittel auf basis einer waessrigen dispersion von lipidkuegelchen
WO1989003208A1 (fr) * 1987-10-16 1989-04-20 Board Of Regents, The University Of Texas System Poudres pre-liposomiques de macrolide de polyene
WO1990000389A1 (fr) * 1988-07-07 1990-01-25 Regents Of The University Of Minnesota Compositions de liposomes lyophilises contenant une cyclosporine
EP0472225A3 (en) * 1985-12-11 1992-06-10 L V M H Recherche Hydrated lammelar lipidic phases or liposomes containing tretinoid
EP0534823A1 (fr) * 1991-09-30 1993-03-31 L'oreal Composition cosmétique anhydre de maquillage comprenant une phase grasse et procédé de traitement cosmétique utilisant cette composition

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FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
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DE2914788A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
DE2914789A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Injizierbare arzneimittel mit entzuendungshemmender wirkung
CA1173360A (fr) * 1979-06-22 1984-08-28 Jurg Schrank Produits pharmaceutiques
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FR2441385A1 (fr) * 1978-11-17 1980-06-13 Serono Ist Farm Procede de preparation extemporanee de liposomes et liposomes ainsi obtenus
FR2446635A1 (fr) * 1979-01-19 1980-08-14 Erba Farmitalia Compositions pharmaceutiques consistant en liposomes et procede pour les preparer
FR2455458A1 (fr) * 1979-05-02 1980-11-28 Kureha Chemical Ind Co Ltd Liposomes contenant une substance active, notamment un principe actif de medicament
EP0028917A2 (fr) * 1979-11-08 1981-05-20 Merck & Co. Inc. Vésicules lipidiques porteuses de surfaces carbohydratées et utilisées comme véhicules à action directe sur la lymphe pour des substances thérapeutiques et de diagnostic, leur utilisation et procédé pour leur préparation
EP0028917A3 (en) * 1979-11-08 1981-07-15 Merck & Co. Inc. Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them
FR2472386A1 (fr) * 1979-12-27 1981-07-03 Human Oltoanyagtermelo
EP0161445A1 (fr) * 1984-03-31 1985-11-21 Green Cross Corporation Complexe hydrosoluble d'un médicament et procédé pour sa préparation
US4687762A (en) * 1984-03-31 1987-08-18 Green Cross Corporation Water soluble drug complex and method for production of same
EP0472225A3 (en) * 1985-12-11 1992-06-10 L V M H Recherche Hydrated lammelar lipidic phases or liposomes containing tretinoid
DE3713493A1 (de) * 1986-04-22 1987-10-29 Oreal Kosmetisches oder pharmazeutisches mittel auf basis einer waessrigen dispersion von lipidkuegelchen
WO1989003208A1 (fr) * 1987-10-16 1989-04-20 Board Of Regents, The University Of Texas System Poudres pre-liposomiques de macrolide de polyene
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
WO1990000389A1 (fr) * 1988-07-07 1990-01-25 Regents Of The University Of Minnesota Compositions de liposomes lyophilises contenant une cyclosporine
EP0534823A1 (fr) * 1991-09-30 1993-03-31 L'oreal Composition cosmétique anhydre de maquillage comprenant une phase grasse et procédé de traitement cosmétique utilisant cette composition
FR2681781A1 (fr) * 1991-09-30 1993-04-02 Oreal Composition cosmetique anhydre de maquillage comprenant une phase grasse et procede de traitement cosmetique utilisant cette composition.
US6319508B1 (en) 1991-09-30 2001-11-20 L'oreal Anhydrous cosmetic composition containing a fatty phase and pro-liposomes
US6572870B2 (en) 1991-09-30 2003-06-03 L'oreal Anhydrous cosmetic makeup composition containing a fatty phase

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DE2818655A1 (de) 1978-11-23
JPS53142514A (en) 1978-12-12
SE454049B (sv) 1988-03-28
BE866697A (fr) 1978-11-03
FI63856B (fi) 1983-05-31
NO150184C (no) 1984-09-05
IT7823207A0 (it) 1978-05-10
NO153121C (no) 1986-01-22
NO150184B (no) 1984-05-28
SE453962B (sv) 1988-03-21
CH652615A5 (de) 1985-11-29
IT1094811B (it) 1985-08-10
SE8201350L (sv) 1982-03-04
IE780464L (en) 1978-11-10
JPS6252724B2 (fr) 1987-11-06
SE7805276L (sv) 1978-11-11
DK156765C (da) 1990-02-19
US4311712A (en) 1982-01-19
DK206578A (da) 1978-11-11
NO840064L (no) 1978-11-13
DK156765B (da) 1989-10-02
IL54270A (en) 1981-06-29
IL54270A0 (en) 1978-06-15
SE8201351L (sv) 1982-03-04
DK122388A (da) 1988-03-07
AU3423578A (en) 1979-09-20
NO153121B (no) 1985-10-14
DE2818655C2 (de) 1987-05-14
ZA781416B (en) 1979-03-28
IL61475A0 (en) 1980-12-31
CH650944A5 (de) 1985-08-30
AU514644B2 (en) 1981-02-19
FR2390159B1 (fr) 1983-01-14
IE46571B1 (en) 1983-07-27
CA1114758A (fr) 1981-12-22
DK122388D0 (da) 1988-03-07
GB1575343A (en) 1980-09-17
NL7805005A (nl) 1978-11-14
NO834219L (no) 1978-11-13
US4370349A (en) 1983-01-25
SE440725B (sv) 1985-08-19
FI781012A (fi) 1978-11-11
NO780838L (no) 1978-11-13
NZ186696A (en) 1980-10-08
FI63856C (fi) 1983-09-12

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