|
US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
|
KR100286412B1
(ko)
*
|
1993-12-29 |
2001-04-16 |
더블유. 지. 콜 |
치환된 모르폴린 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
|
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
|
US5747491A
(en)
*
|
1994-05-05 |
1998-05-05 |
Merck Sharp & Dohme Ltd. |
Morpholine derivatives and their use as antagonists of tachikinins
|
|
GB9505491D0
(en)
*
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9523244D0
(en)
*
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6117855A
(en)
*
|
1996-10-07 |
2000-09-12 |
Merck Sharp & Dohme Ltd. |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
|
|
US5750549A
(en)
*
|
1996-10-15 |
1998-05-12 |
Merck & Co., Inc. |
Cycloalkyl tachykinin receptor antagonists
|
|
CA2273856A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating bipolar disorders
|
|
JP2001508412A
(ja)
*
|
1996-12-02 |
2001-06-26 |
メルク シヤープ エンド ドーム リミテツド |
認識障害の治療のためのnk−1受容体拮抗薬の使用
|
|
US5977104A
(en)
*
|
1996-12-02 |
1999-11-02 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating bipolar disorders
|
|
JP2001507678A
(ja)
*
|
1996-12-02 |
2001-06-12 |
メルク シヤープ エンド ドーム リミテツド |
運動障害の治療のためのnk−1受容体拮抗薬の使用
|
|
JP2001504851A
(ja)
*
|
1996-12-02 |
2001-04-10 |
メルク シヤープ エンド ドーム リミテツド |
性的機能不全の治療のためのnk−1受容体拮抗薬の使用
|
|
US6114315A
(en)
*
|
1996-12-02 |
2000-09-05 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
|
|
US6613765B1
(en)
*
|
1996-12-02 |
2003-09-02 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating major depressive disorders
|
|
US6100256A
(en)
*
|
1996-12-02 |
2000-08-08 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
|
|
EP0977572A1
(en)
*
|
1997-04-24 |
2000-02-09 |
Merck Sharp & Dohme Ltd. |
Use of nk-1 receptor antagonists for treating eating disorders
|
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO1999007375A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU738047B2
(en)
*
|
1997-08-04 |
2001-09-06 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating mania
|
|
US6087348A
(en)
*
|
1997-12-01 |
2000-07-11 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating stress disorders
|
|
GB9813025D0
(en)
*
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Chemical synthesis
|
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
|
WO2000050398A2
(en)
|
1999-02-24 |
2000-08-31 |
F. Hoffmann-La Roche Ag |
Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists
|
|
BR0008494A
(pt)
|
1999-02-24 |
2002-02-05 |
Hoffmann La Roche |
Derivados de 3-fenilpiridina e seu uso como antagonista do receptor de nk-1
|
|
ES2226622T3
(es)
|
1999-02-24 |
2005-04-01 |
F. Hoffmann-La Roche Ag |
Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1.
|
|
US6291465B1
(en)
|
1999-03-09 |
2001-09-18 |
Hoffmann-La Roche Inc. |
Biphenyl derivatives
|
|
FR2792835B3
(fr)
*
|
1999-04-27 |
2001-05-25 |
Sanofi Sa |
Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
|
|
GB9923748D0
(en)
|
1999-10-07 |
1999-12-08 |
Glaxo Group Ltd |
Chemical compounds
|
|
USRE39921E1
(en)
|
1999-10-07 |
2007-11-13 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
ATE387429T1
(de)
|
1999-11-03 |
2008-03-15 |
Amr Technology Inc |
Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin
|
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
|
US6552025B1
(en)
*
|
1999-11-24 |
2003-04-22 |
Emory University |
Diimino-piperazine derivatives for use as modulators of cell regulation
|
|
PT1103545E
(pt)
*
|
1999-11-29 |
2004-03-31 |
Hoffmann La Roche |
2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-totil-piridin-3-il)-isobutiramida
|
|
US6452001B2
(en)
|
2000-05-25 |
2002-09-17 |
Hoffmann-La Roche Inc. |
Diazapane derivatives useful as antagonists of neurokinin 1 receptor and methods for their formation
|
|
US6482829B2
(en)
|
2000-06-08 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
|
|
CN100430401C
(zh)
|
2000-07-11 |
2008-11-05 |
Amr科技公司 |
新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
|
|
RS50932B
(sr)
|
2000-07-14 |
2010-08-31 |
F. Hoffmann-La Roche Ag. |
N-oksidi kao prolekovi 4-fenil-piridinskih derivata koji su antagonisti nk1 receptora
|
|
TWI287003B
(en)
|
2000-07-24 |
2007-09-21 |
Hoffmann La Roche |
4-phenyl-pyridine derivatives
|
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
|
GB0025354D0
(en)
*
|
2000-10-17 |
2000-11-29 |
Glaxo Group Ltd |
Chemical compounds
|
|
YU39503A
(sh)
|
2000-11-22 |
2006-05-25 |
F. Hoffmann-La Roche Ag. |
Derivati pirimidina
|
|
US6642226B2
(en)
|
2001-02-06 |
2003-11-04 |
Hoffman-La Roche Inc. |
Substituted phenyl-piperidine methanone compounds
|
|
GB0108594D0
(en)
*
|
2001-04-05 |
2001-05-23 |
Glaxo Group Ltd |
Chemical compounds
|
|
US20030055026A1
(en)
*
|
2001-04-17 |
2003-03-20 |
Dey L.P. |
Formoterol/steroid bronchodilating compositions and methods of use thereof
|
|
US6667344B2
(en)
|
2001-04-17 |
2003-12-23 |
Dey, L.P. |
Bronchodilating compositions and methods
|
|
US6849624B2
(en)
|
2001-07-31 |
2005-02-01 |
Hoffmann-La Roche Inc. |
Aromatic and heteroaromatic substituted amides
|
|
US6638981B2
(en)
|
2001-08-17 |
2003-10-28 |
Epicept Corporation |
Topical compositions and methods for treating pain
|
|
MY130373A
(en)
*
|
2001-10-29 |
2007-06-29 |
Malesci Sas |
Linear basic compounds having nk-2 antagonist activity and formulations thereof
|
|
US6903129B2
(en)
*
|
2001-12-14 |
2005-06-07 |
Hoffman-La Roche Inc. |
D-proline prodrugs
|
|
GB0203022D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0203020D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
|
WO2003066589A1
(en)
*
|
2002-02-08 |
2003-08-14 |
Glaxo Group Limited |
Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
|
|
AR039625A1
(es)
*
|
2002-04-18 |
2005-03-02 |
Merck & Co Inc |
Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
|
|
EP1556054A4
(en)
*
|
2002-05-29 |
2007-09-05 |
Univ California |
ANTAGONIZING NK1 RECEPTORS RESTRICT DRUG ABUSE
|
|
NZ537206A
(en)
*
|
2002-06-27 |
2007-06-29 |
Astellas Pharma Inc |
Aminoalcohol derivatives
|
|
US20040023935A1
(en)
*
|
2002-08-02 |
2004-02-05 |
Dey, L.P. |
Inhalation compositions, methods of use thereof, and process for preparation of same
|
|
US20040109826A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Dey, L.P. |
Stabilized albuterol compositions and method of preparation thereof
|
|
WO2004067007A1
(en)
*
|
2003-01-31 |
2004-08-12 |
F. Hoffmann-La Roche Ag |
NEW CRYSTALLINE MODIFICATION OF 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4(4-FLUORO-2-METHYL-PHENYL)-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE
|
|
JP4490421B2
(ja)
|
2003-07-03 |
2010-06-23 |
エフ.ホフマン−ラ ロシュ アーゲー |
統合失調症を処置するデュアルnk1/nk3アンタゴニスト
|
|
TWI359675B
(en)
*
|
2003-07-10 |
2012-03-11 |
Dey L P |
Bronchodilating β-agonist compositions
|
|
US7288658B2
(en)
|
2003-07-15 |
2007-10-30 |
Hoffmann-La Roche Inc. |
Process for preparation of pyridine derivatives
|
|
EP1669348A4
(en)
*
|
2003-09-30 |
2009-03-11 |
Eisai R&D Man Co Ltd |
NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND
|
|
JP2007517069A
(ja)
|
2003-12-31 |
2007-06-28 |
サイデックス・インコーポレイテッド |
スルホアルキルエーテルγ−シクロデキストリンおよびコルチコステロイドを含む吸入製剤
|
|
US20070020298A1
(en)
*
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
|
|
US20070020299A1
(en)
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
|
|
ES2246687B2
(es)
|
2004-02-11 |
2006-11-16 |
Miguel Muñoz Saez |
Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
|
|
ATE446581T1
(de)
*
|
2004-03-12 |
2009-11-15 |
Trinity College Dublin |
Magnetoresistives medium
|
|
ES2909080T3
(es)
|
2004-04-23 |
2022-05-05 |
Cydex Pharmaceuticals Inc |
Formulación de DPI que contiene sulfoalquil éter ciclodextrina
|
|
CN101119969B
(zh)
|
2004-07-15 |
2014-04-09 |
阿尔巴尼分子研究公司 |
芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
|
|
US20090227799A1
(en)
*
|
2004-08-09 |
2009-09-10 |
Kazutaka Nakamoto |
Novel Antimalarial Agent Containing Heterocyclic Compound
|
|
AU2005273961A1
(en)
*
|
2004-08-11 |
2006-02-23 |
Williamsburg Holdings Llc |
Noncardiotoxic pharmaceutical compounds
|
|
US7223737B1
(en)
|
2004-08-13 |
2007-05-29 |
Alcon, Inc. |
Method of treating dry eye disorders using glycosides
|
|
AR051475A1
(es)
*
|
2004-11-05 |
2007-01-17 |
Merck & Co Inc |
Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
|
|
US7176205B2
(en)
|
2005-02-22 |
2007-02-13 |
Hoffmann-La Roche Inc. |
Bi-pyridinyl derivatives as NK-1 antagonists
|
|
BRPI0609699A2
(pt)
|
2005-03-23 |
2010-04-20 |
Hoffmann La Roche |
metabolitos para antatonistas de nk-1 para êmese
|
|
JP4874958B2
(ja)
*
|
2005-03-30 |
2012-02-15 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ピリジン誘導体を含有する抗真菌剤
|
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
|
EA019115B1
(ru)
|
2005-07-15 |
2014-01-30 |
Олбани Молекьюлар Рисерч, Инк. |
Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
|
|
WO2007039420A1
(en)
|
2005-09-23 |
2007-04-12 |
F. Hoffmann-La Roche Ag |
Novel dosage formulation
|
|
KR20080048502A
(ko)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
|
WO2007039883A2
(en)
*
|
2005-10-05 |
2007-04-12 |
Ranbaxy Laboratories Limited |
Process for preparation of aprepitant
|
|
US7629331B2
(en)
|
2005-10-26 |
2009-12-08 |
Cydex Pharmaceuticals, Inc. |
Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
|
|
TWI385169B
(zh)
*
|
2005-10-31 |
2013-02-11 |
Eisai R&D Man Co Ltd |
經雜環取代之吡啶衍生物及含有彼之抗真菌劑
|
|
US20070160542A1
(en)
*
|
2005-12-20 |
2007-07-12 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
|
US20070185066A1
(en)
*
|
2005-12-20 |
2007-08-09 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
|
US20070178049A1
(en)
*
|
2005-12-20 |
2007-08-02 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
|
US20070249572A1
(en)
*
|
2005-12-20 |
2007-10-25 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
|
US20070197486A1
(en)
*
|
2005-12-20 |
2007-08-23 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids
|
|
KR20080089659A
(ko)
*
|
2006-02-03 |
2008-10-07 |
그렌마크 파머수티칼스 엘티디. |
아프레피탄트의 비정질 및 결정 형태 및 그것의 제조 방법
|
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
JP2009526619A
(ja)
*
|
2006-02-15 |
2009-07-23 |
ティカ レーケメデル アーベー |
質量減量を伴うコルチコステロイドの滅菌
|
|
US8183264B2
(en)
*
|
2006-09-21 |
2012-05-22 |
Eisai R&D Managment Co., Ltd. |
Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
|
|
AU2007300627B2
(en)
|
2006-09-22 |
2012-02-16 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
|
GEP20115337B
(en)
|
2007-01-10 |
2011-11-25 |
St Di Ricerche Di Biologia Molecolare P Angeletti Spa |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
|
WO2008090114A1
(en)
|
2007-01-24 |
2008-07-31 |
Glaxo Group Limited |
Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
|
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Msd株式会社 |
インドールジオン誘導体
|
|
KR101163847B1
(ko)
|
2007-04-20 |
2012-07-09 |
에프. 호프만-라 로슈 아게 |
이중 nk1/nk3 수용체 길항제로서의 피롤리딘 유도체
|
|
AU2008246798A1
(en)
*
|
2007-04-27 |
2008-11-13 |
Eisai R&D Management Co., Ltd. |
Salt of heterocycle-substituted pyridine derivative or crystal thereof
|
|
TW200841879A
(en)
|
2007-04-27 |
2008-11-01 |
Eisai R&D Man Co Ltd |
Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
|
|
EP1994930A1
(en)
*
|
2007-05-22 |
2008-11-26 |
Novartis AG |
Triazol compounds for treating biofilm formation
|
|
AU2008269154B2
(en)
|
2007-06-27 |
2014-06-12 |
Merck Sharp & Dohme Llc |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
US12370352B2
(en)
|
2007-06-28 |
2025-07-29 |
Cydex Pharmaceuticals, Inc. |
Nasal and ophthalmic delivery of aqueous corticosteroid solutions
|
|
ATE517100T1
(de)
|
2007-08-07 |
2011-08-15 |
Hoffmann La Roche |
Pyrrolidinarylether als nk3-rezeptorantagonisten
|
|
US20090076007A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched aprepitant
|
|
US20090076008A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched fosaprepitant
|
|
US8513287B2
(en)
|
2007-12-27 |
2013-08-20 |
Eisai R&D Management Co., Ltd. |
Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
|
|
EP2254420A4
(en)
|
2008-02-20 |
2012-02-15 |
Targia Pharmaceuticals |
CNS PHARMACEUTICALS AND METHOD FOR THEIR USE
|
|
US8598184B2
(en)
|
2008-03-03 |
2013-12-03 |
Tiger Pharmatech |
Protein kinase inhibitors
|
|
US20100048914A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
|
WO2010018595A2
(en)
|
2008-07-17 |
2010-02-18 |
Glenmark Generics Limited |
Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
|
|
US8188119B2
(en)
*
|
2008-10-24 |
2012-05-29 |
Eisai R&D Management Co., Ltd |
Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
|
|
EP3023433A1
(en)
|
2009-02-05 |
2016-05-25 |
Tokai Pharmaceuticals, Inc. |
Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
|
|
KR20110136813A
(ko)
|
2009-03-17 |
2011-12-21 |
다이이찌 산쿄 가부시키가이샤 |
아미드 유도체
|
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
|
CN102595902B
(zh)
|
2009-05-12 |
2015-04-29 |
阿尔巴尼分子研究公司 |
7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
|
|
MX2011011900A
(es)
|
2009-05-12 |
2012-01-20 |
Squibb Bristol Myers Co |
Formas cristalinas de (s)-7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4 -(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y usos de las misma.
|
|
WO2010132437A1
(en)
|
2009-05-12 |
2010-11-18 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
|
UY32799A
(es)
*
|
2009-07-24 |
2011-02-28 |
Novartis Ag |
Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos
|
|
US8188079B2
(en)
*
|
2009-08-19 |
2012-05-29 |
Hoffman-La Roche Inc. |
3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
|
|
MY174452A
(en)
|
2009-10-14 |
2020-04-19 |
Schering Corp |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
WO2011045817A2
(en)
*
|
2009-10-15 |
2011-04-21 |
Sandoz Private Limited |
Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
|
|
US20130245253A1
(en)
*
|
2010-03-26 |
2013-09-19 |
Department Of Veterans Affairs |
Conjugated Neuroactive Steroid Compositions And Methods Of Use
|
|
US8487102B2
(en)
|
2010-04-20 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
|
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
|
PL2483255T3
(pl)
|
2010-07-13 |
2014-03-31 |
Novartis Ag |
Pochodne oksazyny i ich zastosowanie w leczeniu zaburzeń neurologicznych
|
|
US9446029B2
(en)
|
2010-07-27 |
2016-09-20 |
Colorado State University Research Foundation |
Use of NK-1 receptor antagonists in management of visceral pain
|
|
US8518907B2
(en)
|
2010-08-02 |
2013-08-27 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
|
ES2376564B1
(es)
|
2010-08-12 |
2013-01-24 |
Manuel Vicente Salinas Martín |
Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
|
|
EP3587574B1
(en)
|
2010-08-17 |
2022-03-16 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
|
US8946216B2
(en)
|
2010-09-01 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
|
US8524897B2
(en)
|
2011-01-12 |
2013-09-03 |
Novartis Ag |
Crystalline oxazine derivative
|
|
PH12013501480A1
(en)
|
2011-01-13 |
2022-10-26 |
Novartis Ag |
Novel heterocyclic derivatives and their use in the treatment of neurological disorders
|
|
CN102127031B
(zh)
*
|
2011-01-17 |
2012-10-17 |
江苏江神药物化学有限公司 |
一种麻黄碱类化合物季胺盐及其合成方法和应用
|
|
US9067924B2
(en)
*
|
2011-03-04 |
2015-06-30 |
Hoffmann-La Roche Inc. |
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
|
|
FR2973031B1
(fr)
*
|
2011-03-23 |
2013-11-29 |
Univ Strasbourg |
Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique
|
|
CA2830984C
(en)
*
|
2011-03-25 |
2020-02-11 |
Universite Laval |
Inhibitors of 17.beta.-hsd1, 17.beta.-hsd3 and 17.beta.-hsd10.
|
|
CA2833009A1
(en)
|
2011-04-21 |
2012-10-26 |
Merck Sharp & Dohme Corp. |
Insulin-like growth factor-1 receptor inhibitors
|
|
WO2012146692A1
(en)
|
2011-04-29 |
2012-11-01 |
Sandoz Ag |
Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
|
|
CN103608344B
(zh)
*
|
2011-06-07 |
2016-11-23 |
霍夫曼-拉罗奇有限公司 |
[1,3]噁嗪类
|
|
EP2729147B1
(en)
|
2011-07-04 |
2017-09-06 |
IRBM - Science Park S.p.A. |
Nk-1 receptor antagonists for treating corneal neovascularisation
|
|
CN102977142B
(zh)
*
|
2011-09-02 |
2017-03-29 |
江苏豪森药业集团有限公司 |
福沙匹坦二甲葡胺的制备方法
|
|
WO2013036835A1
(en)
|
2011-09-08 |
2013-03-14 |
Sage Therapeutics, Inc. |
Neuroactive steroids, compositions, and uses thereof
|
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
|
US20150297613A1
(en)
|
2011-12-13 |
2015-10-22 |
Servicio Andaluz De Salud |
Use of agents that alter the peritumoral environment for the treatment of cancer
|
|
US8338413B1
(en)
|
2012-03-07 |
2012-12-25 |
Novartis Ag |
Oxazine derivatives and their use in the treatment of neurological disorders
|
|
WO2013168176A2
(en)
*
|
2012-03-30 |
2013-11-14 |
Glenmark Generics Limited |
Process for preparation of fosaprepitant and salt thereof
|
|
CZ304982B6
(cs)
*
|
2012-04-30 |
2015-03-11 |
Zentiva, K.S. |
Způsob přípravy a čištění nových polymorfů intermediátu fosaprepitantu
|
|
EP3919620A1
(en)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
|
CN102675369B
(zh)
*
|
2012-05-16 |
2017-07-11 |
北京华众思康医药技术有限公司 |
一种制备[3‑[(2r)‑[(1r)‑1‑[3,5‑二(三氟甲基)苯基]乙氧基]‑3(s)‑(4‑氟苯基)吗啉‑4‑基]甲基]‑5‑氧代‑4,5‑二氢‑[1,2,4]‑三唑‑1‑基]膦酸一苄酯的新方法
|
|
SG10201704858PA
(en)
*
|
2012-05-31 |
2017-07-28 |
Repros Therapeutics Inc |
Formulations and methods for vaginal delivery of antiprogestins
|
|
EP2866797B1
(en)
|
2012-07-06 |
2020-04-29 |
Pharmathen S.A. |
Stable injectable pharmaceutical composition of neurokinin 1 receptor antagonist and process for preparation thereof
|
|
JP6280554B2
(ja)
|
2012-09-28 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
Erk阻害剤である新規化合物
|
|
US20150119367A1
(en)
*
|
2012-10-29 |
2015-04-30 |
Allergan, Inc. |
Phosphate Esters of Bimatoprost and the Prostamides
|
|
US8796305B2
(en)
|
2012-11-05 |
2014-08-05 |
Bayer Pharma Aktiengesellschaft |
Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
US9126998B2
(en)
|
2012-11-05 |
2015-09-08 |
Bayer Pharma AG |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
US9624214B2
(en)
|
2012-11-05 |
2017-04-18 |
Bayer Pharma Aktiengesellschaft |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
US8778964B2
(en)
|
2012-11-05 |
2014-07-15 |
Bayer Pharma Aktiengesellschaft |
Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
|
|
DK2925888T3
(en)
|
2012-11-28 |
2017-12-18 |
Merck Sharp & Dohme |
COMPOSITIONS AND METHODS OF CANCER TREATMENT
|
|
AR094116A1
(es)
|
2012-12-20 |
2015-07-08 |
Merck Sharp & Dohme |
Imidazopiridinas sustituidas como inhibidores de hdm2
|
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
|
ES2493693B1
(es)
|
2013-02-11 |
2015-07-07 |
Servicio Andaluz De Salud |
Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1
|
|
US20160009755A1
(en)
*
|
2013-03-01 |
2016-01-14 |
Revlon Consumer Products Corporation |
Cyrrhetinic alkyl esters and protected derivatives thereof
|
|
RS67266B1
(sr)
|
2013-03-13 |
2025-10-31 |
Sage Therapeutics Inc |
Neuroaktivni steroidi i postupci za njihovu upotrebu
|
|
KR20150127720A
(ko)
|
2013-03-14 |
2015-11-17 |
유니버시티 오브 매릴랜드, 발티모어 |
안드로겐 수용체 하향 조절제 및 그의 용도
|
|
WO2014169462A1
(zh)
*
|
2013-04-18 |
2014-10-23 |
西安力邦医药科技有限责任公司 |
具有抗癌活性的7-α-[9-(4,4,5,5,-五氟戊基亚硫酰基)壬基]-雌甾-1,3,5(10)-三烯-3,17β-二醇的酯类衍生物及其制备方法
|
|
ES2625744T3
(es)
|
2013-06-04 |
2017-07-20 |
Bayer Pharma Aktiengesellschaft |
Imidazo[1,2-a]piridinas sustituidas con 3-arilo y su uso
|
|
WO2015023710A1
(en)
|
2013-08-12 |
2015-02-19 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
EP3062808B1
(en)
|
2013-10-28 |
2021-09-29 |
The Regents of the University of California |
Treatment of metastatic prostate cancer
|
|
CN104650142B
(zh)
*
|
2013-11-25 |
2018-06-22 |
山东新时代药业有限公司 |
一种福沙匹坦二甲葡胺的制备方法
|
|
CN103694146B
(zh)
*
|
2013-12-04 |
2015-10-28 |
深圳万乐药业有限公司 |
2-(2-氯-1-亚乙基)酰肼甲酸甲酯的制备方法
|
|
ES2541870B1
(es)
|
2013-12-27 |
2016-05-12 |
Servicio Andaluz De Salud |
Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer
|
|
WO2015101596A2
(en)
|
2013-12-30 |
2015-07-09 |
Oncoprevent Gmbh |
Neurokinin-1 receptor antagonists for use in a method of prevention of cancer
|
|
CA2939793A1
(en)
|
2014-02-19 |
2015-08-27 |
Bayer Pharma Aktiengesellschaft |
3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
|
|
WO2015140199A1
(de)
|
2014-03-21 |
2015-09-24 |
Bayer Pharma Aktiengesellschaft |
Cyano-substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
|
|
WO2015195967A1
(en)
|
2014-06-18 |
2015-12-23 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
|
TW201613888A
(en)
|
2014-09-26 |
2016-04-16 |
Helsinn Healthcare Sa |
Crystalline forms of an NK-1 antagonist
|
|
EP3227287B1
(de)
|
2014-12-02 |
2019-08-07 |
Bayer Pharma Aktiengesellschaft |
Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
|
|
SMT202100476T1
(it)
|
2015-07-06 |
2021-09-14 |
Sage Therapeutics Inc |
Ossisteroli e metodi di uso degli stessi
|
|
BR112018000129B1
(pt)
|
2015-07-06 |
2024-01-09 |
Sage Therapeutics, Inc |
Compostos oxiesteróis, seus usos e composição farmacêutica
|
|
WO2017021880A1
(en)
|
2015-08-03 |
2017-02-09 |
Leiutis Pharmaceuticals Pvt Ltd |
Liquid formulations of fosaprepitant
|
|
US10005803B2
(en)
|
2015-10-06 |
2018-06-26 |
Helsinn Healthcare Sa |
Crystalline forms of fosnetupitant
|
|
US9913853B2
(en)
|
2015-11-03 |
2018-03-13 |
Cipla Limited |
Stabilized liquid fosaprepitant formulations
|
|
WO2017093899A1
(en)
|
2015-12-01 |
2017-06-08 |
Piramal Enterprises Limited |
A process for preparation of fosaprepitant dimeglumine and an intermediate thereof
|
|
CN105837526B
(zh)
*
|
2016-01-22 |
2018-02-27 |
浙江工业大学 |
一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
|
|
SI3436022T1
(sl)
|
2016-04-01 |
2022-08-31 |
Sage Therapeutics, Inc. |
Oksisteroli in postopki za uporabo le-teh
|
|
WO2017193046A1
(en)
|
2016-05-06 |
2017-11-09 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
|
CN107353303B
(zh)
|
2016-05-09 |
2020-09-01 |
上海奥博生物医药技术有限公司 |
一种福沙匹坦磷酸酯中间体的制备方法
|
|
SG11201809708PA
(en)
|
2016-06-06 |
2018-11-29 |
Helsinn Healthcare Sa |
Physiologically balanced injectable formulations of fosnetupitant
|
|
ES2884071T3
(es)
|
2016-07-07 |
2021-12-10 |
Sage Therapeutics Inc |
24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
|
|
MX392270B
(es)
|
2016-09-30 |
2025-03-24 |
Sage Therapeutics Inc |
Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
|
|
EP3525785B1
(en)
|
2016-10-12 |
2025-08-27 |
Merck Sharp & Dohme LLC |
Kdm5 inhibitors
|
|
EP4105223B1
(en)
|
2016-10-18 |
2025-04-30 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
|
CN110267966B
(zh)
|
2016-10-18 |
2022-07-08 |
萨奇治疗股份有限公司 |
氧甾醇及其使用方法
|
|
IL312486B2
(en)
|
2017-04-10 |
2025-05-01 |
Chase Therapeutics Corp |
NK1 antagonist combination and method for treating synucleinopathies
|
|
EA202090180A1
(ru)
|
2017-06-30 |
2020-05-26 |
Чейс Терапьютикс Корпорейшн |
Композиции nk1-антагониста и способы лечения депрессии
|
|
WO2019038656A1
(en)
|
2017-08-21 |
2019-02-28 |
Leiutis Pharmaceuticals Pvt, Ltd |
NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY
|
|
CN109694390A
(zh)
*
|
2017-10-24 |
2019-04-30 |
齐鲁制药有限公司 |
一种福沙匹坦氮氧化物
|
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
|
EP3706747B1
(en)
|
2017-11-08 |
2025-09-03 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
WO2019162519A1
(en)
|
2018-02-26 |
2019-08-29 |
Ospedale San Raffaele S.R.L. |
Nk-1 antagonists for use in the treatment of ocular pain
|
|
EP3833355A4
(en)
|
2018-08-07 |
2022-05-11 |
Merck Sharp & Dohme Corp. |
PRMT5 INHIBITORS
|
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
|
WO2020033284A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
US20230134843A1
(en)
|
2020-03-11 |
2023-05-04 |
Ospedale San Raffaele S.R.L. |
Treatment of stem cell deficiency
|
|
IL296635A
(en)
|
2020-04-03 |
2022-11-01 |
Nerre Therapeutics Ltd |
An nk-1 receptor antagonist for the treatment of a disease selected from sepsis, septic shock, acute respiratory distress syndrome (ARDS), or multiple organ dysfunction syndrome (MODS)
|
|
MX2022014901A
(es)
|
2020-06-02 |
2023-01-18 |
Nerre Therapeutics Ltd |
Antagonistas del receptor de neuroquinina (nk)-1 para su uso en el tratamiento de condiciones de fibrosis pulmonar promovidas por lesion mecanica a los pulmones.
|
|
US20240024339A1
(en)
|
2020-11-19 |
2024-01-25 |
Nippon Kayaku Kabushiki Kaisha |
Composition containing water-soluble drug causing vascular disorder, solution for use in preparation of administration solution containing water-soluble drug causing vascular disorder, kit, agent for suppressing vascular disorder, and solution containing nonionic surfactant
|
|
US11541066B2
(en)
|
2021-03-04 |
2023-01-03 |
Extrovis Ag |
Stable ready-to-use parenteral compositions of fosaprepitant
|
|
CN113582982B
(zh)
*
|
2021-06-15 |
2023-06-16 |
山东罗欣药业集团股份有限公司 |
一种nk1受体拮抗剂的制备方法
|
|
WO2025008409A2
(en)
|
2023-07-03 |
2025-01-09 |
Preeti Jha |
Substituted 2-phenylpiperidine compounds for use in the diagnosis, treatment and/or prevention of cancer
|
|
WO2025085662A1
(en)
|
2023-10-17 |
2025-04-24 |
Vanderbilt University |
Compounds for tocolytic use
|