|
US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
|
DE69428913T2
(de)
*
|
1993-12-29 |
2002-05-29 |
Merck Sharp & Dohme Ltd., Hoddesdon |
Substituierte morpholinderivate und ihre verwendung als arzneimittel
|
|
TW385308B
(en)
*
|
1994-03-04 |
2000-03-21 |
Merck & Co Inc |
Prodrugs of morpholine tachykinin receptor antagonists
|
|
JPH10500944A
(ja)
*
|
1994-05-05 |
1998-01-27 |
メルク シヤープ エンド ドーム リミテツド |
モルホリン誘導体及びタキキニンのアンタゴニストとしてのそれらの使用
|
|
GB9505491D0
(en)
*
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9523244D0
(en)
*
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6117855A
(en)
*
|
1996-10-07 |
2000-09-12 |
Merck Sharp & Dohme Ltd. |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
|
|
US5750549A
(en)
*
|
1996-10-15 |
1998-05-12 |
Merck & Co., Inc. |
Cycloalkyl tachykinin receptor antagonists
|
|
JP2001504851A
(ja)
*
|
1996-12-02 |
2001-04-10 |
メルク シヤープ エンド ドーム リミテツド |
性的機能不全の治療のためのnk−1受容体拮抗薬の使用
|
|
US6114315A
(en)
*
|
1996-12-02 |
2000-09-05 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
|
|
EP0942732B1
(en)
*
|
1996-12-02 |
2004-11-17 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating movement disorders
|
|
US6100256A
(en)
*
|
1996-12-02 |
2000-08-08 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
|
|
CA2273856A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating bipolar disorders
|
|
US6613765B1
(en)
*
|
1996-12-02 |
2003-09-02 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating major depressive disorders
|
|
AU734860B2
(en)
*
|
1996-12-02 |
2001-06-21 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating cognitive disorders
|
|
US5977104A
(en)
*
|
1996-12-02 |
1999-11-02 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating bipolar disorders
|
|
JP2001524960A
(ja)
*
|
1997-04-24 |
2001-12-04 |
メルク シヤープ エンド ドーム リミテツド |
摂食障害を治療するためのnk−1受容体拮抗薬の使用
|
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO1999007376A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating mania
|
|
WO1999007375A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
|
US6087348A
(en)
*
|
1997-12-01 |
2000-07-11 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating stress disorders
|
|
GB9813025D0
(en)
*
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Chemical synthesis
|
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
|
DE60045564D1
(de)
|
1999-02-24 |
2011-03-03 |
Hoffmann La Roche |
4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
|
|
CN1134417C
(zh)
|
1999-02-24 |
2004-01-14 |
弗·哈夫曼-拉罗切有限公司 |
3-苯基吡啶衍生物及其作为nk-1受体拮抗剂的应用
|
|
CN1131212C
(zh)
|
1999-02-24 |
2003-12-17 |
弗·哈夫曼-拉罗切有限公司 |
苯基-和吡啶基衍生物
|
|
US6291465B1
(en)
|
1999-03-09 |
2001-09-18 |
Hoffmann-La Roche Inc. |
Biphenyl derivatives
|
|
FR2792835B3
(fr)
*
|
1999-04-27 |
2001-05-25 |
Sanofi Sa |
Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
|
|
USRE39921E1
(en)
|
1999-10-07 |
2007-11-13 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
GB9923748D0
(en)
|
1999-10-07 |
1999-12-08 |
Glaxo Group Ltd |
Chemical compounds
|
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
|
KR100885986B1
(ko)
|
1999-11-03 |
2009-03-03 |
에이엠알 테크놀로지, 인크. |
노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
|
|
US6552025B1
(en)
*
|
1999-11-24 |
2003-04-22 |
Emory University |
Diimino-piperazine derivatives for use as modulators of cell regulation
|
|
ES2208205T3
(es)
*
|
1999-11-29 |
2004-06-16 |
F. Hoffmann-La Roche Ag |
2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il-4-otolil-piridin-3-il)-isobutiramida.
|
|
US6452001B2
(en)
|
2000-05-25 |
2002-09-17 |
Hoffmann-La Roche Inc. |
Diazapane derivatives useful as antagonists of neurokinin 1 receptor and methods for their formation
|
|
US6482829B2
(en)
|
2000-06-08 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
|
|
CA2415532C
(en)
|
2000-07-11 |
2010-05-11 |
Albany Molecular Research, Inc. |
Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
|
|
CA2415890C
(en)
|
2000-07-14 |
2009-04-07 |
F. Hoffmann-La Roche Ag |
N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
|
|
TWI287003B
(en)
|
2000-07-24 |
2007-09-21 |
Hoffmann La Roche |
4-phenyl-pyridine derivatives
|
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
|
GB0025354D0
(en)
*
|
2000-10-17 |
2000-11-29 |
Glaxo Group Ltd |
Chemical compounds
|
|
YU39503A
(sh)
|
2000-11-22 |
2006-05-25 |
F. Hoffmann-La Roche Ag. |
Derivati pirimidina
|
|
US6642226B2
(en)
|
2001-02-06 |
2003-11-04 |
Hoffman-La Roche Inc. |
Substituted phenyl-piperidine methanone compounds
|
|
GB0108594D0
(en)
*
|
2001-04-05 |
2001-05-23 |
Glaxo Group Ltd |
Chemical compounds
|
|
US6667344B2
(en)
|
2001-04-17 |
2003-12-23 |
Dey, L.P. |
Bronchodilating compositions and methods
|
|
US20030055026A1
(en)
*
|
2001-04-17 |
2003-03-20 |
Dey L.P. |
Formoterol/steroid bronchodilating compositions and methods of use thereof
|
|
US6849624B2
(en)
|
2001-07-31 |
2005-02-01 |
Hoffmann-La Roche Inc. |
Aromatic and heteroaromatic substituted amides
|
|
US6638981B2
(en)
|
2001-08-17 |
2003-10-28 |
Epicept Corporation |
Topical compositions and methods for treating pain
|
|
MY130373A
(en)
*
|
2001-10-29 |
2007-06-29 |
Malesci Sas |
Linear basic compounds having nk-2 antagonist activity and formulations thereof
|
|
US6903129B2
(en)
*
|
2001-12-14 |
2005-06-07 |
Hoffman-La Roche Inc. |
D-proline prodrugs
|
|
GB0203020D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0203022D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
|
WO2003066589A1
(en)
*
|
2002-02-08 |
2003-08-14 |
Glaxo Group Limited |
Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
|
|
AR039625A1
(es)
*
|
2002-04-18 |
2005-03-02 |
Merck & Co Inc |
Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
|
|
WO2003101459A1
(en)
*
|
2002-05-29 |
2003-12-11 |
The Regents Of The University Of California |
Antagonizing nk1 receptors inhibits consumption of substances of abuse
|
|
NZ537206A
(en)
*
|
2002-06-27 |
2007-06-29 |
Astellas Pharma Inc |
Aminoalcohol derivatives
|
|
US20040023935A1
(en)
*
|
2002-08-02 |
2004-02-05 |
Dey, L.P. |
Inhalation compositions, methods of use thereof, and process for preparation of same
|
|
US20040109826A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Dey, L.P. |
Stabilized albuterol compositions and method of preparation thereof
|
|
CN100562320C
(zh)
|
2003-01-31 |
2009-11-25 |
弗·哈夫曼-拉罗切有限公司 |
2-(3,5-二-三氟甲基-苯基)-N-[6-(1,1-二氧代-1λ6-硫代吗啉-4-基)-4-(4-氟-2-甲基-苯基)-吡啶-3-基]-N-甲基-异丁酰胺的新晶体变体
|
|
JP4490421B2
(ja)
|
2003-07-03 |
2010-06-23 |
エフ.ホフマン−ラ ロシュ アーゲー |
統合失調症を処置するデュアルnk1/nk3アンタゴニスト
|
|
TWI359675B
(en)
*
|
2003-07-10 |
2012-03-11 |
Dey L P |
Bronchodilating β-agonist compositions
|
|
US7288658B2
(en)
|
2003-07-15 |
2007-10-30 |
Hoffmann-La Roche Inc. |
Process for preparation of pyridine derivatives
|
|
US7932272B2
(en)
*
|
2003-09-30 |
2011-04-26 |
Eisai R&D Management Co., Ltd. |
Antifungal agent containing heterocyclic compound
|
|
US20070020299A1
(en)
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
|
|
CA2552641A1
(en)
|
2003-12-31 |
2005-07-21 |
Cydex, Inc. |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
|
|
US20070020298A1
(en)
*
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
|
|
ES2246687B2
(es)
|
2004-02-11 |
2006-11-16 |
Miguel Muñoz Saez |
Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
|
|
WO2005088655A1
(en)
*
|
2004-03-12 |
2005-09-22 |
The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin |
A magnetoresistive medium
|
|
HUE058227T2
(hu)
|
2004-04-23 |
2022-07-28 |
Cydex Pharmaceuticals Inc |
DPI készítmény, amely szulfoalkil-éter-ciklodextrint tartalmaz
|
|
KR101389246B1
(ko)
|
2004-07-15 |
2014-04-24 |
브리스톨-마이어스스퀴브컴파니 |
아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
|
|
US20090227799A1
(en)
*
|
2004-08-09 |
2009-09-10 |
Kazutaka Nakamoto |
Novel Antimalarial Agent Containing Heterocyclic Compound
|
|
SG169238A1
(en)
*
|
2004-08-11 |
2011-03-30 |
Williamsburg Holdings Llc |
Noncardiotoxic pharmaceutical compounds
|
|
US7223737B1
(en)
|
2004-08-13 |
2007-05-29 |
Alcon, Inc. |
Method of treating dry eye disorders using glycosides
|
|
AR051475A1
(es)
*
|
2004-11-05 |
2007-01-17 |
Merck & Co Inc |
Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
|
|
CA2601935C
(en)
|
2005-02-22 |
2013-04-09 |
F. Hoffmann-La Roche Ag |
Nk1 antagonists
|
|
US20100047338A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
|
RU2404969C2
(ru)
|
2005-03-23 |
2010-11-27 |
Ф. Хоффманн-Ля Рош Аг |
Метаболиты антагонистов nk-1 против рвоты
|
|
WO2006106711A1
(ja)
*
|
2005-03-30 |
2006-10-12 |
Eisai R & D Management Co., Ltd. |
ピリジン誘導体を含有する抗真菌剤
|
|
EP1888050B1
(en)
|
2005-05-17 |
2012-03-21 |
Merck Sharp & Dohme Ltd. |
cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
|
|
ZA200800440B
(en)
|
2005-07-15 |
2009-12-30 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
|
SI1928427T1
(sl)
|
2005-09-23 |
2010-03-31 |
Hoffmann La Roche |
Nove formulacije za doziranje
|
|
US8293900B2
(en)
|
2005-09-29 |
2012-10-23 |
Merck Sharp & Dohme Corp |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
EP1934204A2
(en)
*
|
2005-10-05 |
2008-06-25 |
Ranbaxy Laboratories, Ltd. |
Process for preparation of aprepitant
|
|
US7629331B2
(en)
|
2005-10-26 |
2009-12-08 |
Cydex Pharmaceuticals, Inc. |
Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
|
|
TWI385169B
(zh)
*
|
2005-10-31 |
2013-02-11 |
Eisai R&D Man Co Ltd |
經雜環取代之吡啶衍生物及含有彼之抗真菌劑
|
|
US20070178049A1
(en)
*
|
2005-12-20 |
2007-08-02 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
|
US20070249572A1
(en)
*
|
2005-12-20 |
2007-10-25 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
|
US20070185066A1
(en)
*
|
2005-12-20 |
2007-08-09 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
|
US20070160542A1
(en)
*
|
2005-12-20 |
2007-07-12 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
|
US20070197486A1
(en)
*
|
2005-12-20 |
2007-08-23 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids
|
|
US9227958B2
(en)
*
|
2006-02-03 |
2016-01-05 |
Glenmark Pharmaceuticals Limited |
Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
|
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US20070191323A1
(en)
*
|
2006-02-15 |
2007-08-16 |
Verus Pharmaceuticals, Inc. |
Stable corticosteroid mixtures
|
|
WO2008035726A1
(en)
*
|
2006-09-21 |
2008-03-27 |
Eisai R & D Management Co., Ltd. |
Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
|
|
EP2698157B1
(en)
|
2006-09-22 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
|
EP2805945B1
(en)
|
2007-01-10 |
2019-04-03 |
MSD Italia S.r.l. |
Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
|
|
JP2010516734A
(ja)
|
2007-01-24 |
2010-05-20 |
グラクソ グループ リミテッド |
3,5−ジアミノ−6−(2,3−ジクロロフェニル)−1,2,4−トリアジンまたはr(−)−2,4−ジアミノ−5−(2,3−ジクロロフェニル)−6−フルオロメチルピリミジンを含む医薬組成物
|
|
US8106086B2
(en)
|
2007-04-02 |
2012-01-31 |
Msd K.K. |
Indoledione derivative
|
|
CN101657418B
(zh)
|
2007-04-20 |
2012-05-30 |
弗·哈夫曼-拉罗切有限公司 |
作为nk1/nk3受体双重拮抗剂的吡咯烷衍生物
|
|
TW200841879A
(en)
|
2007-04-27 |
2008-11-01 |
Eisai R&D Man Co Ltd |
Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
|
|
EP2143723A4
(en)
*
|
2007-04-27 |
2011-05-18 |
Eisai R&D Man Co Ltd |
SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME
|
|
EP1994930A1
(en)
*
|
2007-05-22 |
2008-11-26 |
Novartis AG |
Triazol compounds for treating biofilm formation
|
|
US8389553B2
(en)
|
2007-06-27 |
2013-03-05 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
US12370352B2
(en)
|
2007-06-28 |
2025-07-29 |
Cydex Pharmaceuticals, Inc. |
Nasal and ophthalmic delivery of aqueous corticosteroid solutions
|
|
CN101778837A
(zh)
|
2007-08-07 |
2010-07-14 |
弗·哈夫曼-拉罗切有限公司 |
作为nk3受体拮抗剂的吡咯烷芳基-醚
|
|
US20090076007A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched aprepitant
|
|
US20090076008A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched fosaprepitant
|
|
US8513287B2
(en)
|
2007-12-27 |
2013-08-20 |
Eisai R&D Management Co., Ltd. |
Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
|
|
CA2716080C
(en)
|
2008-02-20 |
2016-12-13 |
Targia Pharmaceuticals |
Cns pharmaceutical compositions and methods of use
|
|
KR20100126467A
(ko)
|
2008-03-03 |
2010-12-01 |
타이거 파마테크 |
티로신 키나아제 억제제
|
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
|
WO2010018595A2
(en)
|
2008-07-17 |
2010-02-18 |
Glenmark Generics Limited |
Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
|
|
US8188119B2
(en)
*
|
2008-10-24 |
2012-05-29 |
Eisai R&D Management Co., Ltd |
Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
|
|
AU2010210422A1
(en)
|
2009-02-05 |
2011-08-18 |
Tokai Pharmaceuticals, Inc. |
Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
|
|
MX2011009700A
(es)
|
2009-03-17 |
2011-12-08 |
Daiichi Sankyo Co Ltd |
Derivado de amida.
|
|
US8691825B2
(en)
|
2009-04-01 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of AKT activity
|
|
EP2429295B1
(en)
|
2009-05-12 |
2013-12-25 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
|
CN102638982B
(zh)
|
2009-05-12 |
2015-07-08 |
百时美施贵宝公司 |
(S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
|
|
KR101830447B1
(ko)
|
2009-05-12 |
2018-02-20 |
알바니 몰레큘라 리써치, 인크. |
7-([1,2,4]트리아졸로[1,5-α]피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
|
|
UY32799A
(es)
|
2009-07-24 |
2011-02-28 |
Novartis Ag |
Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos
|
|
US8188079B2
(en)
*
|
2009-08-19 |
2012-05-29 |
Hoffman-La Roche Inc. |
3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
|
|
EP2488028B1
(en)
|
2009-10-14 |
2020-08-19 |
Merck Sharp & Dohme Corp. |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
WO2011045817A2
(en)
|
2009-10-15 |
2011-04-21 |
Sandoz Private Limited |
Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
|
|
US20130245253A1
(en)
*
|
2010-03-26 |
2013-09-19 |
Department Of Veterans Affairs |
Conjugated Neuroactive Steroid Compositions And Methods Of Use
|
|
US8487102B2
(en)
|
2010-04-20 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
|
|
WO2011163330A1
(en)
|
2010-06-24 |
2011-12-29 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
|
BR112012004154A2
(pt)
*
|
2010-07-13 |
2017-05-30 |
Novartis Ag |
"derivados de oxazina e seu uso no tratamento de distúrbios neurológicos"
|
|
US9446029B2
(en)
|
2010-07-27 |
2016-09-20 |
Colorado State University Research Foundation |
Use of NK-1 receptor antagonists in management of visceral pain
|
|
CN107090456B
(zh)
|
2010-08-02 |
2022-01-18 |
瑟纳治疗公司 |
使用短干扰核酸的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1基因表达的抑制
|
|
ES2376564B1
(es)
|
2010-08-12 |
2013-01-24 |
Manuel Vicente Salinas Martín |
Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
|
|
JP2013537423A
(ja)
|
2010-08-17 |
2013-10-03 |
メルク・シャープ・エンド・ドーム・コーポレイション |
低分子干渉核酸(siNA)を用いたB型肝炎ウイルス(HBV)遺伝子発現のRNA干渉媒介性阻害
|
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
|
EP2615916B1
(en)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel erk inhibitors
|
|
DK2632472T3
(en)
|
2010-10-29 |
2018-03-19 |
Sirna Therapeutics Inc |
RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
|
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
|
US8524897B2
(en)
|
2011-01-12 |
2013-09-03 |
Novartis Ag |
Crystalline oxazine derivative
|
|
DK2663561T3
(en)
|
2011-01-13 |
2016-06-06 |
Novartis Ag |
New heterocyclic derivatives and their use in treating neurological disorders
|
|
CN102127031B
(zh)
*
|
2011-01-17 |
2012-10-17 |
江苏江神药物化学有限公司 |
一种麻黄碱类化合物季胺盐及其合成方法和应用
|
|
US9067924B2
(en)
*
|
2011-03-04 |
2015-06-30 |
Hoffmann-La Roche Inc. |
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
|
|
FR2973031B1
(fr)
*
|
2011-03-23 |
2013-11-29 |
Univ Strasbourg |
Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique
|
|
CA2830984C
(en)
*
|
2011-03-25 |
2020-02-11 |
Universite Laval |
Inhibitors of 17.beta.-hsd1, 17.beta.-hsd3 and 17.beta.-hsd10.
|
|
EP2699568A1
(en)
|
2011-04-21 |
2014-02-26 |
Piramal Enterprises Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
|
WO2012146692A1
(en)
|
2011-04-29 |
2012-11-01 |
Sandoz Ag |
Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
|
|
MX2013014007A
(es)
*
|
2011-06-07 |
2014-03-12 |
Hoffmann La Roche |
[1,3] oxazinas.
|
|
DK2729147T3
(en)
|
2011-07-04 |
2017-12-18 |
Irbm - Science Park S P A |
NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
|
|
CN102977142B
(zh)
*
|
2011-09-02 |
2017-03-29 |
江苏豪森药业集团有限公司 |
福沙匹坦二甲葡胺的制备方法
|
|
US20150158903A1
(en)
|
2011-09-08 |
2015-06-11 |
Sage Therapeutics, Inc. |
Neuroactive steroids, compositions, and uses thereof
|
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
|
WO2013087964A1
(es)
|
2011-12-13 |
2013-06-20 |
Servicio Andaluz De Salud |
Uso de agentes modificadores del ambiente peritumoral para el tratamiento del cáncer
|
|
US8338413B1
(en)
|
2012-03-07 |
2012-12-25 |
Novartis Ag |
Oxazine derivatives and their use in the treatment of neurological disorders
|
|
WO2013168176A2
(en)
*
|
2012-03-30 |
2013-11-14 |
Glenmark Generics Limited |
Process for preparation of fosaprepitant and salt thereof
|
|
CZ304982B6
(cs)
*
|
2012-04-30 |
2015-03-11 |
Zentiva, K.S. |
Způsob přípravy a čištění nových polymorfů intermediátu fosaprepitantu
|
|
EP2844261B1
(en)
|
2012-05-02 |
2018-10-17 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
CN102675369B
(zh)
*
|
2012-05-16 |
2017-07-11 |
北京华众思康医药技术有限公司 |
一种制备[3‑[(2r)‑[(1r)‑1‑[3,5‑二(三氟甲基)苯基]乙氧基]‑3(s)‑(4‑氟苯基)吗啉‑4‑基]甲基]‑5‑氧代‑4,5‑二氢‑[1,2,4]‑三唑‑1‑基]膦酸一苄酯的新方法
|
|
JP6341910B2
(ja)
*
|
2012-05-31 |
2018-06-13 |
レプロス セラピューティクス インコーポレイティド |
抗プロゲスチンの経膣送達用製剤およびその送達方法
|
|
EP2866797B1
(en)
|
2012-07-06 |
2020-04-29 |
Pharmathen S.A. |
Stable injectable pharmaceutical composition of neurokinin 1 receptor antagonist and process for preparation thereof
|
|
CN105050598B
(zh)
|
2012-09-28 |
2018-04-27 |
默沙东公司 |
作为erk抑制剂的新型化合物
|
|
CA2889977A1
(en)
*
|
2012-10-29 |
2014-05-08 |
Allergan, Inc. |
Phosphate esters of bimatoprost and the prostamides
|
|
US8796305B2
(en)
|
2012-11-05 |
2014-08-05 |
Bayer Pharma Aktiengesellschaft |
Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
US8778964B2
(en)
|
2012-11-05 |
2014-07-15 |
Bayer Pharma Aktiengesellschaft |
Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
|
|
US9126998B2
(en)
|
2012-11-05 |
2015-09-08 |
Bayer Pharma AG |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
US9624214B2
(en)
|
2012-11-05 |
2017-04-18 |
Bayer Pharma Aktiengesellschaft |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
|
RS56680B1
(sr)
|
2012-11-28 |
2018-03-30 |
Merck Sharp & Dohme |
Kompozicije i postupci za lečenje kancera
|
|
US8846657B2
(en)
|
2012-12-20 |
2014-09-30 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as HDM2 inhibitors
|
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
|
ES2493693B1
(es)
|
2013-02-11 |
2015-07-07 |
Servicio Andaluz De Salud |
Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1
|
|
US20160009755A1
(en)
*
|
2013-03-01 |
2016-01-14 |
Revlon Consumer Products Corporation |
Cyrrhetinic alkyl esters and protected derivatives thereof
|
|
LT2968369T
(lt)
|
2013-03-13 |
2018-12-27 |
Sage Therapeutics, Inc. |
Neuroaktyvūs steroidai ir jų panaudojimo būdai
|
|
KR20150127720A
(ko)
|
2013-03-14 |
2015-11-17 |
유니버시티 오브 매릴랜드, 발티모어 |
안드로겐 수용체 하향 조절제 및 그의 용도
|
|
CA2909418A1
(en)
*
|
2013-04-18 |
2014-10-23 |
Xi'an Libang Pharmaceutical Technology Co., Ltd. |
Ester derivative of 7-.alpha.-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)n onyl]-estra-1,3,5(10)-triene-3,17.beta.-diol having anticancer activity and preparation method thereof
|
|
CN105339368B
(zh)
|
2013-06-04 |
2017-08-15 |
拜耳制药股份公司 |
3‑芳基‑取代的咪唑并[1,2‑a]吡啶及其用途
|
|
WO2015023710A1
(en)
|
2013-08-12 |
2015-02-19 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
|
EP3041938A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
WO2015065919A1
(en)
|
2013-10-28 |
2015-05-07 |
The Regents Of The University Of California |
Treatment of metastatic prostate cancer
|
|
CN104650142B
(zh)
*
|
2013-11-25 |
2018-06-22 |
山东新时代药业有限公司 |
一种福沙匹坦二甲葡胺的制备方法
|
|
CN103694146B
(zh)
*
|
2013-12-04 |
2015-10-28 |
深圳万乐药业有限公司 |
2-(2-氯-1-亚乙基)酰肼甲酸甲酯的制备方法
|
|
ES2541870B1
(es)
|
2013-12-27 |
2016-05-12 |
Servicio Andaluz De Salud |
Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer
|
|
WO2015101596A2
(en)
|
2013-12-30 |
2015-07-09 |
Oncoprevent Gmbh |
Neurokinin-1 receptor antagonists for use in a method of prevention of cancer
|
|
CN106459090A
(zh)
|
2014-02-19 |
2017-02-22 |
拜耳制药股份公司 |
3‑(嘧啶‑2‑基)咪唑并[1,2‑a]吡啶
|
|
EP3119777A1
(de)
|
2014-03-21 |
2017-01-25 |
Bayer Pharma Aktiengesellschaft |
Cyano-substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
|
|
ES2970222T3
(es)
|
2014-06-18 |
2024-05-27 |
Sage Therapeutics Inc |
Oxiesteroles y procedimientos de uso de los mismos
|
|
TW201613888A
(en)
|
2014-09-26 |
2016-04-16 |
Helsinn Healthcare Sa |
Crystalline forms of an NK-1 antagonist
|
|
CA2969268A1
(en)
|
2014-12-02 |
2016-06-09 |
Bayer Pharma Aktiengesellschaft |
Heteroaryl-substituted imidazo[1,2-a]pyridines and their use
|
|
MX376833B
(es)
|
2015-07-06 |
2025-03-07 |
Sage Therapeutics Inc |
Oxiesteroles y metodos de uso de los mismos.
|
|
RS62220B1
(sr)
|
2015-07-06 |
2021-09-30 |
Sage Therapeutics Inc |
Oksisteroli i postupci njihovog korišćenja
|
|
WO2017021880A1
(en)
|
2015-08-03 |
2017-02-09 |
Leiutis Pharmaceuticals Pvt Ltd |
Liquid formulations of fosaprepitant
|
|
US10005803B2
(en)
|
2015-10-06 |
2018-06-26 |
Helsinn Healthcare Sa |
Crystalline forms of fosnetupitant
|
|
US9913853B2
(en)
|
2015-11-03 |
2018-03-13 |
Cipla Limited |
Stabilized liquid fosaprepitant formulations
|
|
US10428097B2
(en)
|
2015-12-01 |
2019-10-01 |
Piramal Enterprises Limited |
Process for preparation of fosaprepitant dimeglumine and an intermediate thereof
|
|
CN105837526B
(zh)
*
|
2016-01-22 |
2018-02-27 |
浙江工业大学 |
一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
|
|
CN114272249A
(zh)
|
2016-04-01 |
2022-04-05 |
萨奇治疗股份有限公司 |
氧甾醇及其使用方法
|
|
US10752653B2
(en)
|
2016-05-06 |
2020-08-25 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
|
CN107353303B
(zh)
|
2016-05-09 |
2020-09-01 |
上海奥博生物医药技术有限公司 |
一种福沙匹坦磷酸酯中间体的制备方法
|
|
MX376118B
(es)
|
2016-06-06 |
2025-03-07 |
Helsinn Healthcare Sa |
Formulaciones inyectables fisiológicamente balanceadas de fosnetupitant.
|
|
AU2017292870B2
(en)
|
2016-07-07 |
2021-10-07 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
|
EP3519422B1
(en)
|
2016-09-30 |
2022-08-31 |
Sage Therapeutics, Inc. |
C7 substituted oxysterols and these compounds for use as nmda modulators
|
|
US10975084B2
(en)
|
2016-10-12 |
2021-04-13 |
Merck Sharp & Dohme Corp. |
KDM5 inhibitors
|
|
ES2952106T3
(es)
|
2016-10-18 |
2023-10-27 |
Sage Therapeutics Inc |
Oxisteroles y procedimientos de utilización de los mismos
|
|
KR20250054838A
(ko)
|
2016-10-18 |
2025-04-23 |
세이지 테라퓨틱스, 인크. |
옥시스테롤 및 그의 사용 방법
|
|
IL312486B2
(en)
|
2017-04-10 |
2025-05-01 |
Chase Therapeutics Corp |
NK1 antagonist combination and method for treating synucleinopathies
|
|
JP7158425B2
(ja)
|
2017-06-30 |
2022-10-21 |
チェイス セラピューティクス コーポレイション |
Nk-1アンタゴニスト組成物およびうつ病の処置における使用法
|
|
WO2019038656A1
(en)
|
2017-08-21 |
2019-02-28 |
Leiutis Pharmaceuticals Pvt, Ltd |
NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY
|
|
CN109694390A
(zh)
*
|
2017-10-24 |
2019-04-30 |
齐鲁制药有限公司 |
一种福沙匹坦氮氧化物
|
|
US11098059B2
(en)
|
2017-11-08 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
|
EP3706742B1
(en)
|
2017-11-08 |
2023-03-15 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
US20210015834A1
(en)
*
|
2018-02-26 |
2021-01-21 |
Ospedale San Raffaele S.R.L. |
Nk-1 antagonists for use in the treatment of ocular pain
|
|
EP3833668B1
(en)
|
2018-08-07 |
2025-03-19 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
CA3108388A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
EP4117673A1
(en)
|
2020-03-11 |
2023-01-18 |
Ospedale San Raffaele S.r.l. |
Treatment of stem cell deficiency
|
|
KR20220165251A
(ko)
|
2020-04-03 |
2022-12-14 |
네르 쎄라퓨틱스 리미티드 |
패혈증, 패혈성 쇼크, 급성 호흡 곤란 증후군 (ards) 또는 다발성 기관 기능장애 증후군 (mods)으로부터 선택된 질환을 치료하기 위한 nk-1 수용체 길항제
|
|
MX2022014901A
(es)
|
2020-06-02 |
2023-01-18 |
Nerre Therapeutics Ltd |
Antagonistas del receptor de neuroquinina (nk)-1 para su uso en el tratamiento de condiciones de fibrosis pulmonar promovidas por lesion mecanica a los pulmones.
|
|
KR20230110283A
(ko)
|
2020-11-19 |
2023-07-21 |
니폰 카야쿠 가부시키가이샤 |
혈관 장애를 유발하는 수용성 의약 함유 조성물, 혈관 장애를 유발하는 수용성 의약 함유 투여액 조제용 용액, 키트, 혈관 장애 억제제 및 비이온계 계면활성제 함유 용액
|
|
US11541066B2
(en)
|
2021-03-04 |
2023-01-03 |
Extrovis Ag |
Stable ready-to-use parenteral compositions of fosaprepitant
|
|
CN113582982B
(zh)
*
|
2021-06-15 |
2023-06-16 |
山东罗欣药业集团股份有限公司 |
一种nk1受体拮抗剂的制备方法
|
|
WO2025008409A2
(en)
|
2023-07-03 |
2025-01-09 |
Preeti Jha |
Substituted 2-phenylpiperidine compounds for use in the diagnosis, treatment and/or prevention of cancer
|
|
WO2025085662A1
(en)
|
2023-10-17 |
2025-04-24 |
Vanderbilt University |
Compounds for tocolytic use
|