FI79554B - Foerfarande foer framstaellning av hyaluronsyrafraktioner med farmaceutisk aktivitet. - Google Patents
Foerfarande foer framstaellning av hyaluronsyrafraktioner med farmaceutisk aktivitet. Download PDFInfo
- Publication number
- FI79554B FI79554B FI843990A FI843990A FI79554B FI 79554 B FI79554 B FI 79554B FI 843990 A FI843990 A FI 843990A FI 843990 A FI843990 A FI 843990A FI 79554 B FI79554 B FI 79554B
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- FI
- Finland
- Prior art keywords
- hyaluronic acid
- molecular weight
- fraction
- membrane
- mixture
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Förfarande för framställning av en väsentligen ren, icke-inflammatorisk hyaluronsyrafraktion, k a n n e -tecknat av att - en blandning av hyaluronsyror med olika molekylvikter extraheras frän vävnadsutgängsämne som innehäller hyaluronsyra och - den erhällna blandningen underkastas molekylfiltrering för att erhälla en hyaluronsyrafraktion, vars molekyl-viktsmedelvärde Mr ca 50.000 - 100.000, ca 250.000 - 350.000 eller ca 500.000 - 730.000, varvid nämnda fraktion är väsentligen fri frän hyaluronsyra, vars molelkylvikt understiger 30.000.
2. Förfarande enligt patentkrav 1, kännetecknat av att hyaluronsyrablandningen underkastas molekylfiltrering med ett membran, vars molekylviktsexklusionsgräns är 30.000 för att avskilja de molekyler vars molekylvikt är över 30.000 och därgenom kvarhälla pä membranet en första hyal-uronsyrafraktion, som är väsentligen fri frän hyaluronsyra, vars molekylvikt understiger 30.000.
3. Förfarande enligt patentkrav 2, kännetecknat av att den erhällna första hyaluronsyrafraktionen har ett molekylviktsmedelvärde pä 250.000 - 350.000.
4. Förfarande enligt patentkrav 3, kännetecknat av att - den första hyaluronsyrafraktionen underkastas en ytterligare molekylultrafiltrering med ett membran, vars molekylviktsexklusionsgräns är 200.000 för att utesluta molekyler med en molekylvikt över 200.000, - ultrafiltreringen fortsätts tills volymen av den blandning som underkastas ultrafiltrering är reducerad tili 10 % av den ursprungliga volymen, och - den blandning som passerat genom membranet samlas för att därgenom erhälla en andra hyaluronsyrafraktions- 40 79554 produkt vars molekylviktsmedelvärde är 50.000 - 100.000.
5. Förfarande enligt patentkrav 4, kännetecknat av att den blandning som kvarhällits pä membranet samlas efter ultrafiltreringssteget med ett membran, vars molekylvikts-exklusionsgräns är ca 200.000 1 krav 4, varvld en tredje hyaluronsyrafraktionsprodukt erhälles, vars molekylviktsmedelvärde är 500.000 - 730.000.
6. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att hyaluronsyrablandningen erhälles genom att underkasta utgängsvävnadsmaterialet lösningsmedelsextraktion, tili exempel lösningsmedels-extraktion utförd med aceton.
7. Förfarande enligt patentkrav 6, kännetecknat av att den erhällna hyaluronsyrablandningen underkastas därefter enzymatisk sönderdelning.
8. Förfarande enligt patentkrav 7, kännetecknat av att den enzymatiska sönderdelningen utförs med papain.
9. Förfarande för rening av en hyaluronsyrablandning frän inflammatoriska ämnen, kännetecknat av att - en hyaluronsyrablandning underkastas molekylfiltrering för att erhälla en hyaluronsyrafraktion, vars molekylviktsmedelvärde är ca 50.000 - 100.000, ca 250.000 - 350.000 eller ca 500.000 - 730.000, varvid nämnda fraktion är väsentligen fri frän hyaluronsyror, vars molelkylvikt understiger 30.000, och som bildar en väsentligen icke-inflammatorisk hyaluronsyrafraktion.
10. Reningsförfarande enligt patentkrav 9, kännetecknat av att hyaluronsyrablandningen underkastas molekylfiltrering med ett membran, vars molekylvikts-exklusionsgräns är 30.000, för att avskilja de molekyler vars molekylvikt är över 30.000 och därgenom kvarhälla pä li
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8349143A IT1212892B (it) | 1983-10-11 | 1983-10-11 | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
| IT4914383 | 1983-10-11 | ||
| IT4897984 | 1984-10-09 | ||
| IT48979/84A IT1178041B (it) | 1984-10-09 | 1984-10-09 | Uso dell'acido ialuronico come veicolo per farmaci oftalmici e composizioni farmaceutiche contenenti questa sostanza |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI843990A0 FI843990A0 (fi) | 1984-10-11 |
| FI843990L FI843990L (fi) | 1985-04-12 |
| FI79554B true FI79554B (fi) | 1989-09-29 |
| FI79554C FI79554C (sv) | 1990-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| FI843990A FI79554C (sv) | 1983-10-11 | 1984-10-11 | Förfarande för framställning av hyaluronsyrafraktioner med farmaceutis k aktivitet |
Country Status (20)
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|---|---|
| EP (1) | EP0138572B1 (sv) |
| KR (1) | KR860001148B1 (sv) |
| AR (1) | AR231992A1 (sv) |
| AU (1) | AU575861B2 (sv) |
| BE (1) | BE900810A (sv) |
| CA (1) | CA1205031A (sv) |
| CH (1) | CH666897A5 (sv) |
| DE (1) | DE3482812D1 (sv) |
| DK (1) | DK171029B1 (sv) |
| ES (1) | ES8507573A1 (sv) |
| FI (1) | FI79554C (sv) |
| FR (1) | FR2553099B1 (sv) |
| HK (1) | HK66091A (sv) |
| HU (1) | HU195523B (sv) |
| IE (1) | IE57931B1 (sv) |
| IN (1) | IN163192B (sv) |
| LU (1) | LU85582A1 (sv) |
| NO (1) | NO169637C (sv) |
| PT (1) | PT79339B (sv) |
| SG (1) | SG59491G (sv) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
| SE442820B (sv) * | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
| SE8501723L (sv) * | 1985-04-09 | 1986-10-10 | Pharmacia Ab | Preparation att anvendas vid behandling av ledinflammation |
| IL78720A (en) * | 1985-05-09 | 1990-01-18 | Hill David Cullis | Preparation of high-purity hyaluronic acid from synovial fluid |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5202431A (en) * | 1985-07-08 | 1993-04-13 | Fidia, S.P.A. | Partial esters of hyaluronic acid |
| FR2584606A1 (fr) * | 1985-07-12 | 1987-01-16 | Dropic | Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif |
| AU600257B2 (en) * | 1986-03-21 | 1990-08-09 | International Pharmaceutical Products, Inc. | Non-inflammatory hyaluronic acid fraction and process for preparing it |
| EP0244178A3 (en) * | 1986-04-28 | 1989-02-08 | Iolab, Inc | Intraocular dosage compositions and method of use |
| AU610512B2 (en) * | 1986-12-11 | 1991-05-23 | Biomatrix Incorporated | Improved hyaluronate-poly (ethylene oxide) mixtures |
| US5079236A (en) * | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
| EP0323522A4 (en) * | 1987-07-07 | 1989-08-30 | Santen Pharmaceutical Co Ltd | ARTIFICIAL TEAR. |
| US5916880A (en) * | 1987-12-21 | 1999-06-29 | Bukh Meditec A/S | Reduction of skin wrinkling using sulphated sugars |
| US5510329A (en) * | 1988-04-26 | 1996-04-23 | Ramot University For Applied Research And Industrial Development Ltd. | Preparations for the treatment of eyes |
| GB2228736A (en) * | 1989-02-10 | 1990-09-05 | Sterivet Lab Ltd | Cosmetic formulation |
| EP0443043B1 (en) * | 1989-09-12 | 1995-04-05 | Shiseido Company Limited | Process of production of low-molecular weight hyaluronic acid |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| US5141928B1 (en) * | 1989-12-20 | 1995-11-14 | Brujo Inc | Ophthalmic medication |
| NL8903155A (nl) * | 1989-12-23 | 1991-07-16 | Stamicarbon | Harssamenstelling op basis van een polyesterhars, een aminohars en een epoxyhars. |
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- 1984-10-10 IN IN711/CAL/84A patent/IN163192B/en unknown
- 1984-10-10 DK DK485384A patent/DK171029B1/da not_active IP Right Cessation
- 1984-10-10 NO NO844054A patent/NO169637C/no not_active IP Right Cessation
- 1984-10-10 LU LU85582A patent/LU85582A1/fr unknown
- 1984-10-10 CH CH4866/84A patent/CH666897A5/fr not_active IP Right Cessation
- 1984-10-10 EP EP84306914A patent/EP0138572B1/en not_active Expired - Lifetime
- 1984-10-10 DE DE8484306914T patent/DE3482812D1/de not_active Expired - Lifetime
- 1984-10-10 IE IE2596/84A patent/IE57931B1/en not_active IP Right Cessation
- 1984-10-10 FR FR848415547A patent/FR2553099B1/fr not_active Expired
- 1984-10-11 ES ES536675A patent/ES8507573A1/es not_active Expired
- 1984-10-11 AR AR298247A patent/AR231992A1/es active
- 1984-10-11 PT PT79339A patent/PT79339B/pt not_active IP Right Cessation
- 1984-10-11 HU HU843811A patent/HU195523B/hu unknown
- 1984-10-11 AU AU34148/84A patent/AU575861B2/en not_active Expired
- 1984-10-11 BE BE0/213822A patent/BE900810A/nl not_active IP Right Cessation
- 1984-10-11 CA CA000465231A patent/CA1205031A/en not_active Expired
- 1984-10-11 KR KR1019840006280A patent/KR860001148B1/ko not_active Expired
- 1984-10-11 FI FI843990A patent/FI79554C/sv not_active IP Right Cessation
-
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- 1991-07-25 SG SG594/91A patent/SG59491G/en unknown
- 1991-08-22 HK HK660/91A patent/HK66091A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0138572B1 (en) | 1990-07-25 |
| NO844054L (no) | 1985-04-12 |
| LU85582A1 (fr) | 1985-06-04 |
| DK485384A (da) | 1985-04-12 |
| KR860001148B1 (ko) | 1986-08-18 |
| IE57931B1 (en) | 1993-05-19 |
| BE900810A (nl) | 1985-04-11 |
| FR2553099B1 (fr) | 1989-09-08 |
| FI843990L (fi) | 1985-04-12 |
| FI843990A0 (fi) | 1984-10-11 |
| CA1205031A (en) | 1986-05-27 |
| ES536675A0 (es) | 1985-09-01 |
| NO169637C (no) | 1992-07-22 |
| IE842596L (en) | 1985-04-11 |
| PT79339A (en) | 1984-11-01 |
| HU195523B (en) | 1988-05-30 |
| HUT36834A (en) | 1985-10-28 |
| SG59491G (en) | 1991-08-23 |
| FR2553099A1 (fr) | 1985-04-12 |
| ES8507573A1 (es) | 1985-09-01 |
| AU575861B2 (en) | 1988-08-11 |
| CH666897A5 (fr) | 1988-08-31 |
| DE3482812D1 (de) | 1990-08-30 |
| EP0138572A2 (en) | 1985-04-24 |
| DK171029B1 (da) | 1996-04-22 |
| AU3414884A (en) | 1985-04-18 |
| DK485384D0 (da) | 1984-10-10 |
| AR231992A1 (es) | 1985-04-30 |
| IN163192B (sv) | 1988-08-20 |
| NO169637B (no) | 1992-04-13 |
| PT79339B (en) | 1988-06-16 |
| EP0138572A3 (en) | 1986-02-05 |
| HK66091A (en) | 1991-08-30 |
| KR850002957A (ko) | 1985-05-28 |
| FI79554C (sv) | 1990-01-10 |
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Owner name: FIDIA FARMACEUTICI S.P.A. |
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| MA | Patent expired |