FI63856C - Foerfarande foer framstaellning av liposom-precursorer - Google Patents

Foerfarande foer framstaellning av liposom-precursorer Download PDF

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Publication number
FI63856C
FI63856C FI781012A FI781012A FI63856C FI 63856 C FI63856 C FI 63856C FI 781012 A FI781012 A FI 781012A FI 781012 A FI781012 A FI 781012A FI 63856 C FI63856 C FI 63856C
Authority
FI
Finland
Prior art keywords
lipid
liposome
process according
biologically active
solution
Prior art date
Application number
FI781012A
Other languages
English (en)
Finnish (fi)
Other versions
FI781012A (fi
FI63856B (fi
Inventor
John Raymond Evans
Francis James Thomas Fildes
Jean Elizabeth Oliver
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of FI781012A publication Critical patent/FI781012A/fi
Priority to FI800120A priority Critical patent/FI800120A/fi
Priority to FI800119A priority patent/FI63857C/fi
Application granted granted Critical
Publication of FI63856B publication Critical patent/FI63856B/fi
Publication of FI63856C publication Critical patent/FI63856C/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Claims (9)

1. Förfarande för framställning av en frystorkad, potential liposom innehällande blandning, kännetecknat därav, att man upplöser (a) minst en liposom bildande amfipatisk lipid, (b) minst en i lipid löslig eller vid lipid sig bildande biologiskt aktiv förening och (c) eventuellt minst ett hjälpämne, sora är ett en negativ laddning ästadkommande ämne eller ett en positiv laddning ästadkommande ämne eller kolesterol, i ett lösningsmedel, som förblir fast under frystorkning utan användning av yttre kylning, för framställning av en lösning, och därefter frystorkar nämnda lösning för erhällande av en frystorkad, potential liposom innenällande blandning.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att lipiden är fosfolipid.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att fosfolipiden är naturligt eller syntetiskt lecitin.
4. Förfarande enligt patentkravet 3, kännetecknat därav, att lecitinet är ägglecitin eller dipalmitoyl-fosfatidylkolin.
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att den biologiskt aktiva föreningen är en medioin.
6. Förfarande enligt patentkravet 1, kännetecknat därav, att lösningsmedlet är t-butanol, dioxan, ättiksvra, pyridin eller piperidin.
7. Förfarande enligt nägot av patentkraven 1-6, kännetecknat därav, att vatten eller kloroform är närvarande i lösningen, som utsätts för frystorkning.
8. Förfarande för framställning av ett vattenhaltigt liposompreparat, vilket innehäller vatten, ätminstone en liposom-bildande amfipatisk lipid, ätminstone en i lipid löslig eller i lipid sig bindande biologiskt aktiv förening och eventuellt ätminstone ett hjälpmedel, vilket utgörs av ett ämne, vilket ger en negativ laddning eller ett ämne, vilket ger en positiv laddning, eller kolesterol, kännetecknat därav, att man dispergerar en frystorkad blandning innehallande potentiell
FI781012A 1977-05-10 1978-04-03 Foerfarande foer framstaellning av liposom-precursorer FI63856C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI800120A FI800120A (fi) 1977-05-10 1980-01-15 Foerfarande foer framstaellning av liposom-preparat
FI800119A FI63857C (fi) 1977-05-10 1980-01-15 Foerfarande foer framstaellning av frystorkade liposom-preparat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB19510/77A GB1575343A (en) 1977-05-10 1977-05-10 Method for preparing liposome compositions containing biologically active compounds
GB1951077 1977-05-10

Publications (3)

Publication Number Publication Date
FI781012A FI781012A (fi) 1978-11-11
FI63856B FI63856B (fi) 1983-05-31
FI63856C true FI63856C (fi) 1983-09-12

Family

ID=10130587

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781012A FI63856C (fi) 1977-05-10 1978-04-03 Foerfarande foer framstaellning av liposom-precursorer

Country Status (19)

Country Link
US (2) US4311712A (sv)
JP (1) JPS53142514A (sv)
AU (1) AU514644B2 (sv)
BE (1) BE866697A (sv)
CA (1) CA1114758A (sv)
CH (2) CH652615A5 (sv)
DE (1) DE2818655A1 (sv)
DK (2) DK156765C (sv)
FI (1) FI63856C (sv)
FR (1) FR2390159A1 (sv)
GB (1) GB1575343A (sv)
IE (1) IE46571B1 (sv)
IL (2) IL54270A (sv)
IT (1) IT1094811B (sv)
NL (1) NL7805005A (sv)
NO (3) NO150184C (sv)
NZ (1) NZ186696A (sv)
SE (3) SE440725B (sv)
ZA (1) ZA781416B (sv)

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NL7805005A (nl) 1978-11-14
GB1575343A (en) 1980-09-17
AU514644B2 (en) 1981-02-19
IT7823207A0 (it) 1978-05-10
SE7805276L (sv) 1978-11-11
DK156765C (da) 1990-02-19
BE866697A (fr) 1978-11-03
IE780464L (en) 1978-11-10
JPS6252724B2 (sv) 1987-11-06
CH652615A5 (de) 1985-11-29
FI781012A (fi) 1978-11-11
IE46571B1 (en) 1983-07-27
US4311712A (en) 1982-01-19
IL54270A0 (en) 1978-06-15
NO150184B (no) 1984-05-28
NO780838L (no) 1978-11-13
NO834219L (no) 1978-11-13
CA1114758A (en) 1981-12-22
DE2818655A1 (de) 1978-11-23
SE453962B (sv) 1988-03-21
SE454049B (sv) 1988-03-28
DK122388A (da) 1988-03-07
FI63856B (fi) 1983-05-31
DE2818655C2 (sv) 1987-05-14
FR2390159A1 (fr) 1978-12-08
ZA781416B (en) 1979-03-28
JPS53142514A (en) 1978-12-12
DK206578A (da) 1978-11-11
SE8201350L (sv) 1982-03-04
IL54270A (en) 1981-06-29
SE8201351L (sv) 1982-03-04
NZ186696A (en) 1980-10-08
NO153121B (no) 1985-10-14
IT1094811B (it) 1985-08-10
FR2390159B1 (sv) 1983-01-14
IL61475A0 (en) 1980-12-31
SE440725B (sv) 1985-08-19
NO153121C (no) 1986-01-22
AU3423578A (en) 1979-09-20
NO840064L (no) 1978-11-13
US4370349A (en) 1983-01-25
NO150184C (no) 1984-09-05
DK156765B (da) 1989-10-02
DK122388D0 (da) 1988-03-07
CH650944A5 (de) 1985-08-30

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