FI61479C - Foerfarande foer framstaellning av spasmolytiska nya d,l-tyrosinderivat - Google Patents

Foerfarande foer framstaellning av spasmolytiska nya d,l-tyrosinderivat Download PDF

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Publication number
FI61479C
FI61479C FI750255A FI750255A FI61479C FI 61479 C FI61479 C FI 61479C FI 750255 A FI750255 A FI 750255A FI 750255 A FI750255 A FI 750255A FI 61479 C FI61479 C FI 61479C
Authority
FI
Finland
Prior art keywords
group
formula
yield
tyrosyl
alk
Prior art date
Application number
FI750255A
Other languages
English (en)
Finnish (fi)
Other versions
FI750255A (fr
FI61479B (fi
Inventor
Francesco Makovec
Luigi Rovati
Paolo Senin
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of FI750255A publication Critical patent/FI750255A/fi
Publication of FI61479B publication Critical patent/FI61479B/fi
Application granted granted Critical
Publication of FI61479C publication Critical patent/FI61479C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI750255A 1974-02-01 1975-01-30 Foerfarande foer framstaellning av spasmolytiska nya d,l-tyrosinderivat FI61479C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT67286/74A IT1062206B (it) 1974-02-01 1974-02-01 Derivati della tirosina attivi sulla muscolatura liscia
IT6728674 1974-02-01

Publications (3)

Publication Number Publication Date
FI750255A FI750255A (fr) 1975-08-02
FI61479B FI61479B (fi) 1982-04-30
FI61479C true FI61479C (fi) 1982-08-10

Family

ID=11301149

Family Applications (2)

Application Number Title Priority Date Filing Date
FI750256A FI63744C (fi) 1974-02-01 1975-01-30 Foerfarande foer framstaellning av nya spasmolytiska tyrosinderivat
FI750255A FI61479C (fi) 1974-02-01 1975-01-30 Foerfarande foer framstaellning av spasmolytiska nya d,l-tyrosinderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI750256A FI63744C (fi) 1974-02-01 1975-01-30 Foerfarande foer framstaellning av nya spasmolytiska tyrosinderivat

Country Status (19)

Country Link
US (1) US4004008A (fr)
JP (2) JPS5417729B2 (fr)
AT (2) AT342026B (fr)
BE (1) BE824995A (fr)
CA (2) CA1047498A (fr)
CH (2) CH605658A5 (fr)
DE (1) DE2503992C2 (fr)
ES (1) ES434323A1 (fr)
FI (2) FI63744C (fr)
FR (1) FR2259592B1 (fr)
GB (1) GB1467927A (fr)
HK (1) HK38979A (fr)
HU (2) HU174825B (fr)
IN (1) IN139364B (fr)
IT (1) IT1062206B (fr)
NL (1) NL167683C (fr)
NO (2) NO144210C (fr)
SE (2) SE413094B (fr)
ZA (1) ZA75530B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5225243A (en) * 1975-08-20 1977-02-25 Toshiba Electric Equip Corp Distributing panel
US4579866A (en) * 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
CA1320734C (fr) * 1986-02-04 1993-07-27 Suntory Limited Derive pyrrolidineamide d'acide acylamine; composition pharmaceutique a base de ce derive
US5198458A (en) * 1986-02-04 1993-03-30 Suntory Limited Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5258407A (en) * 1991-12-31 1993-11-02 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents
US5206373A (en) * 1992-02-28 1993-04-27 Merck & Co., Inc. Process for preparing fibrinogen receptor antagonists
DE10204951A1 (de) * 2002-02-06 2003-08-14 Basf Ag Phenylalaninderivate als Herbizide
CN1894202A (zh) * 2003-12-19 2007-01-10 巴斯福股份公司 苯甲酰基取代的苯基丙氨酸酰胺
NZ565141A (en) 2005-07-19 2010-12-24 Daiichi Sankyo Co Ltd Substituted propanamide derivative and pharmaceutical composition containing the same
WO2011094890A1 (fr) * 2010-02-02 2011-08-11 Argusina Inc. Dérivés phénylalanines et leur utilisation comme modulateurs non peptidiques du récepteur de glp-1
JP2013530963A (ja) 2010-06-09 2013-08-01 レセプトス インコーポレイテッド 新規のｇｌｐ−１受容体安定化薬および調節薬
US9278910B2 (en) 2011-05-31 2016-03-08 Receptos, Inc. GLP-1 receptor stabilizers and modulators
MX365923B (es) 2011-12-12 2019-06-20 Celgene Int Ii Sarl Derivados de acido carboxilico que comprenden cuatro ciclos, que actuan como moduladores del receptor del peptido 1 similar al glucagon (glp-1) para terapia de enfermedades como la diabetes.
CN102659619A (zh) * 2012-04-18 2012-09-12 上海骏捷生化科技有限公司 一种合成酪氨酸衍生物的方法
CN103508920B (zh) * 2012-06-21 2016-03-02 贵州百灵企业集团制药股份有限公司 一种苯丙氨醇化合物的光学异构体的制备方法及其用途
CN103508921B (zh) * 2012-06-21 2015-09-30 贵州百灵企业集团制药股份有限公司 一种苯丙氨醇化合物的制备方法
BR112015031040A8 (pt) 2013-06-11 2018-01-02 Receptos Inc Novos moduladores do receptor de glp-1
ES2819534T3 (es) 2014-07-25 2021-04-16 Receptos Llc Derivados de pirimidina como moduladores del receptor GLP-1
JP2017538711A (ja) 2014-12-10 2017-12-28 セルジーン インターナショナル ツー エスエーアールエル Ｇｌｐ−１レセプターモジュレーター
CN107417560B (zh) * 2017-03-30 2020-05-22 上海常丰生物医药科技有限公司 一种合成盐酸替罗酰胺的方法
CN110015978B (zh) * 2019-04-29 2021-03-19 康化（上海）新药研发有限公司 O-[2-[[叔丁氧羰基]氨基]乙基]-n-[芴甲氧羰基]-l-酪氨酸的合成方法
CN115850107A (zh) * 2022-11-30 2023-03-28 苏州诚和医药化学有限公司 一种工业化合成盐酸替罗酰胺的方法

Also Published As

Publication number Publication date
NL7501193A (nl) 1975-08-05
ZA75530B (en) 1976-01-28
NO750288L (fr) 1975-08-25
FI63744B (fi) 1983-04-29
NO144211C (no) 1981-07-15
HU175156B (hu) 1980-05-28
SE7501115L (sv) 1975-08-04
SE7501114L (sv) 1975-08-04
JPS5417728B2 (fr) 1979-07-02
NL167683B (nl) 1981-08-17
FI750255A (fr) 1975-08-02
FI61479B (fi) 1982-04-30
CA1047498A (fr) 1979-01-30
AT342026B (de) 1978-03-10
ATA74675A (de) 1977-10-15
JPS50116442A (fr) 1975-09-11
CH605658A5 (fr) 1978-10-13
HK38979A (en) 1979-06-22
NO144210C (no) 1981-07-15
CH605657A5 (fr) 1978-10-13
BE824995A (fr) 1975-05-15
ATA74575A (de) 1977-07-15
JPS5417729B2 (fr) 1979-07-02
NO750287L (fr) 1975-08-25
JPS50116441A (fr) 1975-09-11
FR2259592A1 (fr) 1975-08-29
FR2259592B1 (fr) 1978-07-21
IT1062206B (it) 1983-09-20
DE2503992A1 (de) 1975-08-14
IN139364B (fr) 1976-06-12
NO144210B (no) 1981-04-06
SE410850B (sv) 1979-11-12
NO144211B (no) 1981-04-06
CA1048503A (fr) 1979-02-13
FI750256A (fr) 1975-08-02
ES434323A1 (es) 1976-12-16
SE413094B (sv) 1980-04-14
AU7775075A (en) 1976-08-05
FI63744C (fi) 1983-08-10
GB1467927A (en) 1977-03-23
HU174825B (hu) 1980-03-28
US4004008A (en) 1977-01-18
NL167683C (nl) 1982-01-18
AT343632B (de) 1978-06-12
DE2503992C2 (de) 1982-01-21

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Owner name: ROTTA RESEARCH LABORATORIUM S.P.A.