FI3720483T3 - Streptococcus pneumoniaen polysakkaridi-proteiinikonjugaatteja käsittäviä koostumuksia ja niiden käyttömenetelmiä - Google Patents
Streptococcus pneumoniaen polysakkaridi-proteiinikonjugaatteja käsittäviä koostumuksia ja niiden käyttömenetelmiäInfo
- Publication number
- FI3720483T3 FI3720483T3 FIEP18871825.8T FI18871825T FI3720483T3 FI 3720483 T3 FI3720483 T3 FI 3720483T3 FI 18871825 T FI18871825 T FI 18871825T FI 3720483 T3 FI3720483 T3 FI 3720483T3
- Authority
- FI
- Finland
- Prior art keywords
- immunogenic composition
- multivalent immunogenic
- pneumoniae
- polysaccharide
- protein conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762595388P | 2017-12-06 | 2017-12-06 | |
| PCT/US2018/063709 WO2019139692A2 (en) | 2017-12-06 | 2018-12-04 | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3720483T3 true FI3720483T3 (fi) | 2026-01-12 |
Family
ID=66334525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18871825.8T FI3720483T3 (fi) | 2017-12-06 | 2018-12-04 | Streptococcus pneumoniaen polysakkaridi-proteiinikonjugaatteja käsittäviä koostumuksia ja niiden käyttömenetelmiä |
Country Status (35)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN120718167A (zh) | 2014-01-21 | 2025-09-30 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| CA3050120A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| PT3678654T (pt) * | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| EP3678655A4 (en) * | 2017-09-07 | 2021-05-05 | Merck Sharp & Dohme Corp. | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE CARRIER PROTEIN CONJUGATES |
| WO2019050813A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| US12257295B2 (en) | 2017-10-04 | 2025-03-25 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| TWI725359B (zh) * | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| KR20230008923A (ko) | 2018-02-05 | 2023-01-16 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| JP2021522213A (ja) | 2018-04-18 | 2021-08-30 | エスケー バイオサイエンス カンパニー リミテッド | ストレプトコッカス・ニューモニエ莢膜多糖類及びその免疫原性接合体 |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| CA3120922A1 (en) * | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| GEAP202415690A (en) | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| BR112022001654A2 (pt) | 2019-07-31 | 2022-07-12 | Sanofi Pasteur Inc | Composições conjugadas de proteinas de polissacarídeos pneumocócicos multivalentes e métodos de utilização dos mesmos |
| KR20220146451A (ko) * | 2020-01-17 | 2022-11-01 | 인벤트프라이즈 엘엘씨 | 다가 스트렙토코커스 백신 |
| WO2022035816A1 (en) * | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| KR20230097160A (ko) | 2020-11-04 | 2023-06-30 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| EP4145124B1 (en) * | 2021-09-04 | 2025-09-10 | Serum Institute of India Private Limited | Method for monitoring stability of polysaccharide-protein conjugate vaccines |
| IL321069A (en) | 2022-12-01 | 2025-07-01 | Pfizer | Pneumococcal conjugate vaccine preparations |
| AU2024271872A1 (en) | 2023-05-18 | 2025-12-18 | Merck Sharp & Dohme Llc | Compounds and adjuvant formulations useful in pneumococcal vaccines |
| WO2025174398A1 (en) | 2024-02-14 | 2025-08-21 | Merck Sharp & Dohme Llc | 26-valent pneumococcal conjugate vaccines and methods of use thereof |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740421A (en) | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| DE3071552D1 (en) | 1979-09-21 | 1986-05-22 | Hitachi Ltd | Semiconductor switch |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4902506A (en) | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| US4950740A (en) | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| EP0378881B1 (en) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| WO1991001146A1 (en) | 1989-07-14 | 1991-02-07 | Praxis Biologics, Inc. | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| IL98715A0 (en) | 1990-08-13 | 1992-07-15 | American Cyanamid Co | Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| AU685047B2 (en) | 1992-02-11 | 1998-01-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| EP0643559B1 (en) | 1992-05-06 | 1999-04-14 | The President And Fellows Of Harvard College | Diphtheria toxin receptor-binding region |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| DK0616034T3 (da) | 1993-03-05 | 2005-02-21 | Wyeth Corp | Plasmid til fremstilling af CRM-protein og diphtheria toxin |
| NZ274376A (en) | 1993-09-22 | 1997-11-24 | Jackson H M Found Military Med | Activating soluble carbohydrate using cyanylating reagents for the production of immunogenic constructs |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| NZ304715A (en) | 1995-03-22 | 1999-07-29 | Jackson H M Found Military Med | Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten |
| EP0776216A1 (en) | 1995-06-06 | 1997-06-04 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
| JP4469026B2 (ja) | 1996-10-31 | 2010-05-26 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン |
| KR19980067137A (ko) | 1997-01-31 | 1998-10-15 | 박원훈 | 알긴산염 초미세과립구를 이용한 폐렴구균 감연중에 대한 백신 |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| ES2275499T3 (es) | 1999-03-19 | 2007-06-16 | Glaxosmithkline Biologicals S.A. | Vacuna contra streptococcus pneumoniae. |
| WO2000061761A2 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| AU2001270381B2 (en) | 2000-06-20 | 2007-05-24 | Id Biomedical Corporation | Streptococcus antigens |
| HU227893B1 (en) | 2000-06-29 | 2012-05-29 | Glaxosmithkline Biolog Sa | Vaccine compositions |
| ES2359625T3 (es) | 2000-12-28 | 2011-05-25 | Wyeth Llc | Proteina protectora recombinante de. |
| WO2002083855A2 (en) | 2001-04-16 | 2002-10-24 | Wyeth Holdings Corporation | Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
| AU2002309706A1 (en) | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| CA2452720C (en) | 2001-07-26 | 2012-04-17 | Chiron S.R.L. | Vaccines comprising aluminium adjuvants and histidine |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| GB0130215D0 (en) | 2001-12-18 | 2002-02-06 | Glaxosmithkline Biolog Sa | Vaccine |
| EP1456231A2 (en) | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Streptococcus antigens |
| FR2850106B1 (fr) | 2003-01-17 | 2005-02-25 | Aventis Pasteur | Conjugues obtenus par amination reductrice du polysaccharide capsulaire du pneumocoque de serotype 5 |
| RU2358763C2 (ru) | 2003-02-10 | 2009-06-20 | Элан Фармасьютикалз, Инк. | Композиции иммуноглобулина и способ их получения |
| KR101052996B1 (ko) | 2003-03-13 | 2011-07-29 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 박테리아 세포용해소에 대한 정제 공정 |
| US20060251675A1 (en) | 2003-03-17 | 2006-11-09 | Michael Hagen | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
| AU2003901717A0 (en) | 2003-04-10 | 2003-05-01 | Western Sydney Area Health Service | Identification of streptococcus pneumoniae serotypes |
| DE102004017696A1 (de) | 2004-04-10 | 2005-10-27 | Vorwerk & Co. Interholding Gmbh | Bodenpflegegerät mit einer rotierbaren Bürste |
| WO2005120563A2 (en) | 2004-06-04 | 2005-12-22 | Pharmexa Inc. | Induction of an immune response against streptococcus pneumoniae polysaccharides |
| CA2591421A1 (en) | 2004-12-16 | 2006-06-22 | Stichting Top Institute Food And Nutrition | Novel efficient production process for capsular polysaccharides of pathogenic grampositive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive gram- positive bacteria |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CA2604363C (en) | 2005-04-08 | 2015-06-16 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| NZ562719A (en) | 2005-04-08 | 2008-12-24 | Wyeth Corp | Separation of contaminants from streptococcus pneumoniae polysaccharide by pH manipulation |
| US7764278B2 (en) | 2005-06-30 | 2010-07-27 | Seiko Epson Corporation | Integrated circuit device and electronic instrument |
| PL1973564T3 (pl) | 2005-12-22 | 2017-04-28 | Glaxosmithkline Biologicals S.A. | Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
| AU2006336520B2 (en) | 2005-12-28 | 2011-09-15 | The Uab Research Foundation | Pneumococcal serotypes |
| US8481054B2 (en) | 2005-12-28 | 2013-07-09 | The UAB Foundation | Pneumococcal serotypes |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| WO2008021076A2 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Protein matrix vaccines and methods of making and administering such vaccines |
| PT2074221E (pt) | 2006-10-10 | 2010-09-06 | Wyeth Llc | Métodos melhorados para a separação de polissacáridos tipo 3 de streptococcus pneumoniae |
| PT2129693T (pt) | 2007-03-23 | 2017-02-14 | Wyeth Llc | Processo de purificação abreviado para a produção de polissacáridos capsulares de streptococcus pneumoniae |
| SI2167121T1 (sl) | 2007-06-26 | 2015-12-31 | Glaxosmithkline Biologicals S.A. | Cepivo, ki obsega kapsularne polisaharidne konjugate Streptococcusa pneumoniae |
| US8540955B2 (en) | 2007-07-10 | 2013-09-24 | Wyeth Llc | Process for producing aluminum phosphate |
| ES2749952T3 (es) | 2008-12-18 | 2020-03-24 | Wyeth Llc | Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono |
| KR20110091546A (ko) | 2008-12-18 | 2011-08-11 | 와이어쓰 엘엘씨 | 스트렙토코커스 뉴모니에 혈청형 19ａ 폴리사카라이드 분자량을 조절하는 방법 |
| CN101590224A (zh) | 2009-06-30 | 2009-12-02 | 广州精达医学科技有限公司 | 高效14价肺炎球菌结合疫苗 |
| BR112012005349A2 (pt) | 2009-09-09 | 2016-03-29 | Matrivax Res & Dev Corp | composição imunogênica, seu método de fabricação, método de fabricação de uma composição de vacina de matriz de proteína, e uso |
| GB0917647D0 (en) | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| PT2575870T (pt) | 2010-06-04 | 2017-02-10 | Wyeth Llc | Formulações de vacinas |
| AR084158A1 (es) | 2010-12-10 | 2013-04-24 | Merck Sharp & Dohme | Formulaciones que mitigan la agregacion inducida por agitacion de composiciones inmunogenicas |
| CN102068690A (zh) | 2010-12-31 | 2011-05-25 | 北京民海生物科技有限公司 | 多价肺炎球菌荚膜多糖结合疫苗及其制备方法 |
| GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
| ES2728653T3 (es) | 2011-05-18 | 2019-10-28 | Matrivax Inc | Composiciones vacunales con una matriz proteica que incluye policationes |
| WO2012173876A1 (en) | 2011-06-13 | 2012-12-20 | Merck Sharp & Dohme Corp. | Methods of purification of native or mutant forms of diphtheria toxin |
| KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| CN103623401A (zh) | 2012-08-23 | 2014-03-12 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
| CN103656632B (zh) | 2012-09-24 | 2016-01-13 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖组合物、其制备方法及应用 |
| CN103656631B (zh) * | 2012-09-24 | 2015-08-19 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白缀合物组合物及其制备方法 |
| KR20140075201A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| EP3363806B1 (en) | 2012-12-20 | 2022-11-16 | Pfizer Inc. | Glycoconjugation process |
| ITMI20130142A1 (it) | 2013-01-31 | 2014-08-01 | Biosynth Srl | Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati |
| CN104069488A (zh) | 2013-03-29 | 2014-10-01 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
| BR112016016580B1 (pt) | 2014-01-21 | 2024-01-09 | Pfizer Inc | Processo para a preparação de um conjugado imunogênico, conjugado imunogênico, composição imunogênica, e vacina |
| CN120718167A (zh) | 2014-01-21 | 2025-09-30 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
| IL312327B2 (en) | 2014-01-21 | 2026-02-01 | Pfizer | Immunogenic preparations comprising conjugated capsular saccharide antigens and their uses |
| CN107427568B (zh) | 2015-01-15 | 2021-12-14 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| PE20220774A1 (es) | 2015-05-04 | 2022-05-16 | Pfizer | Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos |
| PE20180460A1 (es) | 2015-06-08 | 2018-03-06 | Serum Inst Of India Private Ltd | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y una formulacion de vacuna multivalente obtenida con los mismos |
| WO2016207905A2 (en) | 2015-06-23 | 2016-12-29 | Biological E Limited | Multivalent pneumococcal conjugate vaccine |
| WO2017011338A1 (en) | 2015-07-10 | 2017-01-19 | President And Fellows Of Harvard College | Sortase-mediated coupling of immunogenic polysaccharide-protein conjugates and their use |
| CN108367063A (zh) | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| IL319202A (en) | 2015-11-17 | 2025-04-01 | Pfizer | Substrates for fermentation methods to create polysaccharides in bacterial cells |
| JP6884145B2 (ja) | 2015-11-20 | 2021-06-09 | ファイザー・インク | 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物 |
| EP4488286A3 (en) | 2016-03-31 | 2025-04-02 | Pogona, Llc | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| EP3474890A1 (en) | 2016-06-22 | 2019-05-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Pneumococcal polysaccharide-protein conjugate composition |
| CN105999254A (zh) | 2016-06-27 | 2016-10-12 | 北京智飞绿竹生物制药有限公司 | 含2型和12f血清型的15价肺炎球菌结合物组合疫苗 |
| WO2018009906A1 (en) | 2016-07-08 | 2018-01-11 | President And Fellows Of Harvard College | Whole cell-protein conjugates and methods of making the same |
| AU2017302541B2 (en) | 2016-07-27 | 2021-08-12 | Sharp Kabushiki Kaisha | Wireless telecommunications methods and apparatus using system information value tag |
| KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| JP7001686B2 (ja) | 2016-08-05 | 2022-02-04 | サノフィ パスツール インコーポレイティッド | 多価肺炎球菌多糖体－タンパク質コンジュゲート組成物 |
| MA45283B1 (fr) | 2016-09-06 | 2021-05-31 | Lg Chemical Ltd | Une composition de multivalent pneumococcal la protéine de polysaccaride-transporteur capsulaire se conjugue et utilisez de cela |
| BR112019006278A2 (pt) | 2016-09-30 | 2019-07-02 | Biological E Limited | composições de vacina pneumocócica multivalente que compreendem conjugados de polissacarídeo-proteína |
| KR20180043122A (ko) | 2016-10-19 | 2018-04-27 | 동국대학교 산학협력단 | 신규링커를 통한 폐렴구균 다당류-단백질 접합체 백신 및 이의 용도 |
| WO2018080213A1 (ko) | 2016-10-28 | 2018-05-03 | 주식회사 엘지화학 | 향상된 IgG 역가를 갖는 다가면역원성 조성물 및 이의 용도 |
| CN108144056A (zh) | 2016-12-02 | 2018-06-12 | 武汉博沃生物科技有限公司 | 多价肺炎球菌多糖结合疫苗及其制备方法 |
| US11413344B2 (en) | 2017-01-20 | 2022-08-16 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| ES3048958T3 (en) | 2017-01-31 | 2025-12-12 | Merck Sharp & Dohme Llc | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| PT3585803T (pt) | 2017-02-24 | 2025-12-22 | Merck Sharp & Dohme | Formulações de vacina pneumocócica conjugada |
| WO2018156465A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier |
| US20200061542A1 (en) | 2017-02-24 | 2020-02-27 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
| CA3050120A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| KR102101879B1 (ko) | 2017-03-15 | 2020-05-29 | 주식회사 엘지화학 | 다가 폐렴구균 백신 조성물 |
| CN107929728A (zh) | 2017-04-19 | 2018-04-20 | 武汉博沃生物科技有限公司 | 一种肺炎球菌蛋白疫苗及其制备方法 |
| MX2019014829A (es) | 2017-06-10 | 2020-08-17 | Inventprise Llc | Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. |
| CN109091668A (zh) | 2017-06-20 | 2018-12-28 | 浙江博和瑞达生物科技有限公司 | 16价肺炎链球菌结合疫苗组合物 |
| CN110996992A (zh) | 2017-08-16 | 2020-04-10 | 默沙东公司 | 肺炎球菌缀合物疫苗制剂 |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| WO2019050813A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| PT3678654T (pt) | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| EP3678655A4 (en) | 2017-09-07 | 2021-05-05 | Merck Sharp & Dohme Corp. | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE CARRIER PROTEIN CONJUGATES |
| AU2018328040B2 (en) | 2017-09-07 | 2025-01-16 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US12257295B2 (en) | 2017-10-04 | 2025-03-25 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| WO2019083865A1 (en) | 2017-10-25 | 2019-05-02 | Merck Sharp & Dohme Corp. | VACCINES WITH ADJUVANT |
| TWI725359B (zh) * | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| JP2019118051A (ja) | 2017-12-27 | 2019-07-18 | 株式会社デンソー | 表示処理装置 |
| CN108159408A (zh) | 2017-12-29 | 2018-06-15 | 云南沃森生物技术股份有限公司 | 一种多价肺炎球菌多糖-蛋白结合物组合物及其制备方法和应用 |
| CN108245674A (zh) | 2018-01-18 | 2018-07-06 | 北京智飞绿竹生物制药有限公司 | 一种多价肺炎球菌结合物组合疫苗的处方及其制备方法 |
| CN108079286B (zh) | 2018-01-19 | 2020-07-31 | 云南沃森生物技术股份有限公司 | 一种13价肺炎球菌多糖-蛋白结合物组合物及其制备方法和应用 |
| KR20230008923A (ko) | 2018-02-05 | 2023-01-16 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
| AU2019215212B2 (en) | 2018-02-05 | 2025-05-15 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| WO2019170068A1 (zh) | 2018-03-05 | 2019-09-12 | 武汉博沃生物科技有限公司 | 一种肺炎链球菌疫苗及其制备方法 |
| JP2021522213A (ja) | 2018-04-18 | 2021-08-30 | エスケー バイオサイエンス カンパニー リミテッド | ストレプトコッカス・ニューモニエ莢膜多糖類及びその免疫原性接合体 |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| US20210236384A1 (en) | 2018-05-07 | 2021-08-05 | Meissner Filtration Products | Lyophilization Bag |
| CN108339115B (zh) | 2018-05-11 | 2020-07-10 | 武汉博沃生物科技有限公司 | 使用重组载体蛋白的肺炎球菌联合疫苗及其制备方法 |
| WO2019220304A1 (en) | 2018-05-14 | 2019-11-21 | Tergene Biotech Pvt. Ltd. | 15 valent pneumococcal polysaccharide conjugate vaccine |
| US20210223262A1 (en) | 2018-06-07 | 2021-07-22 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| CN108524926B (zh) | 2018-06-29 | 2021-06-29 | 康希诺生物股份公司 | 一种多价肺炎球菌结合疫苗的制剂组合及其应用 |
| WO2020009462A1 (ko) | 2018-07-06 | 2020-01-09 | 주식회사 유바이오로직스 | 다가 폐렴구균 다당체-단백질 접합체를 포함하는 면역원성 조성물, 및 이를 포함하는 폐렴구균에 의한 질환 예방 백신 |
| CN108543066A (zh) | 2018-07-17 | 2018-09-18 | 成都安特金生物技术有限公司 | 一种24价肺炎球菌多糖疫苗及其鉴别方法 |
| BR112021001144A2 (pt) | 2018-07-21 | 2021-04-20 | Biological E Limited | formulações da vacina compreendendo sistema conservante |
| KR102879391B1 (ko) | 2018-09-23 | 2025-10-30 | 바이오로지칼 이 리미티드 | 스트렙토코쿠스 뉴모니아에의 정제된 협막 다당류 |
| AU2019358622A1 (en) | 2018-10-12 | 2021-06-17 | Biological E Limited | Multivalent pneumococcal polysaccharide-protein conjugate vaccine |
| CN109336989B (zh) | 2018-10-22 | 2022-05-13 | 北京智飞绿竹生物制药有限公司 | 一种通过粘度控制制备肺炎球菌荚膜多糖的方法 |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| GEAP202415690A (en) | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| WO2020152706A1 (en) | 2019-01-21 | 2020-07-30 | Biological E Limited | Multivalent pneumococcal conjugate vaccine compositions |
| WO2020157772A1 (en) | 2019-01-28 | 2020-08-06 | Biological E Limited | Multivalent pneumococcal polysaccharide-protein conjugate vaccine compositions |
| CN109771640A (zh) | 2019-02-28 | 2019-05-21 | 北京智飞绿竹生物制药有限公司 | 多价肺炎球菌结合疫苗 |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2021014710A (es) | 2019-06-05 | 2022-01-18 | Merck Sharp & Dohme Llc | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
| MX2021014948A (es) | 2019-06-05 | 2022-01-24 | Merck Sharp & Dohme Llc | Metodos de tratamiento de pacientes con una composicion inmunogenica que protege contra el seroripo 29 de s. pneumoniae. |
| CN110302375A (zh) | 2019-06-27 | 2019-10-08 | 康希诺生物股份公司 | 一种糖缀合物及其用途 |
| CN110365663A (zh) * | 2019-06-28 | 2019-10-22 | 北京淇瑀信息科技有限公司 | 一种隔离集群之间的访问方法、装置及电子设备 |
| JP7441301B2 (ja) | 2019-07-18 | 2024-02-29 | セルトリオン， インク． | 球菌多糖類－タンパク質接合体を含む免疫原性組成物 |
| BR112022001654A2 (pt) | 2019-07-31 | 2022-07-12 | Sanofi Pasteur Inc | Composições conjugadas de proteinas de polissacarídeos pneumocócicos multivalentes e métodos de utilização dos mesmos |
| CN111821432B (zh) | 2020-08-05 | 2022-10-18 | 北京智飞绿竹生物制药有限公司 | 一种多价肺炎球菌结合疫苗 |
-
2018
- 2018-12-04 TW TW107143503A patent/TWI725359B/zh active
- 2018-12-04 EA EA202091382A patent/EA202091382A1/ru unknown
- 2018-12-04 HR HRP20260010TT patent/HRP20260010T1/hr unknown
- 2018-12-04 KR KR1020207018995A patent/KR102481327B1/ko active Active
- 2018-12-04 MX MX2020005779A patent/MX2020005779A/es unknown
- 2018-12-04 UA UAA202004012A patent/UA128603C2/uk unknown
- 2018-12-04 NZ NZ765694A patent/NZ765694A/en unknown
- 2018-12-04 SG SG11202005255PA patent/SG11202005255PA/en unknown
- 2018-12-04 PE PE2020000683A patent/PE20201338A1/es unknown
- 2018-12-04 DK DK18871825.8T patent/DK3720483T3/da active
- 2018-12-04 US US16/769,874 patent/US20210177957A1/en not_active Abandoned
- 2018-12-04 CN CN202410165151.6A patent/CN117982633A/zh active Pending
- 2018-12-04 ES ES18871825T patent/ES3058336T3/es active Active
- 2018-12-04 JP JP2020530649A patent/JP7369123B2/ja active Active
- 2018-12-04 BR BR112020011414A patent/BR112020011414B8/pt active IP Right Grant
- 2018-12-04 KR KR1020237029184A patent/KR102686858B1/ko active Active
- 2018-12-04 GE GEAP201815382A patent/GEP20227420B/en unknown
- 2018-12-04 US US16/208,778 patent/US11116828B2/en active Active
- 2018-12-04 EP EP25213789.8A patent/EP4721756A2/en active Pending
- 2018-12-04 CR CR20250169A patent/CR20250169A/es unknown
- 2018-12-04 AR ARP180103546A patent/AR114154A1/es unknown
- 2018-12-04 MA MA051049A patent/MA51049A/fr unknown
- 2018-12-04 SI SI201831290T patent/SI3720483T1/sl unknown
- 2018-12-04 MA MA51048A patent/MA51048B1/fr unknown
- 2018-12-04 WO PCT/US2018/063709 patent/WO2019139692A2/en not_active Ceased
- 2018-12-04 AU AU2018400751A patent/AU2018400751B2/en active Active
- 2018-12-04 LT LTEPPCT/US2018/063709T patent/LT3720483T/lt unknown
- 2018-12-04 CR CR20200245A patent/CR20200245A/es unknown
- 2018-12-04 PL PL18871825.8T patent/PL3720483T3/pl unknown
- 2018-12-04 CN CN201880088694.5A patent/CN111683678B/zh active Active
- 2018-12-04 RS RS20260026A patent/RS67741B1/sr unknown
- 2018-12-04 GE GEAP202215382A patent/GEAP202215382A/en unknown
- 2018-12-04 EP EP18871825.8A patent/EP3720483B1/en active Active
- 2018-12-04 PT PT188718258T patent/PT3720483T/pt unknown
- 2018-12-04 KR KR1020227044655A patent/KR102573200B1/ko active Active
- 2018-12-04 FI FIEP18871825.8T patent/FI3720483T3/fi active
-
2020
- 2020-05-26 IL IL274954A patent/IL274954B/en unknown
- 2020-06-01 NI NI202000040A patent/NI202000040A/es unknown
- 2020-06-03 CL CL2020001478A patent/CL2020001478A1/es unknown
- 2020-06-03 CO CONC2020/0006882A patent/CO2020006882A2/es unknown
- 2020-06-04 JO JOJO/P/2020/0141A patent/JOP20200141B1/ar active
- 2020-06-12 EC ECSENADI202032085A patent/ECSP20032085A/es unknown
- 2020-06-15 PH PH12020550891A patent/PH12020550891A1/en unknown
- 2020-07-13 MX MX2024006606A patent/MX2024006606A/es unknown
-
2021
- 2021-07-13 US US17/374,424 patent/US11850278B2/en active Active
-
2022
- 2022-06-27 JP JP2022102572A patent/JP7458682B2/ja active Active
- 2022-07-13 AR ARP220101837A patent/AR126443A2/es unknown
- 2022-07-30 AU AU2022209360A patent/AU2022209360B2/en active Active
-
2023
- 2023-11-09 US US18/505,504 patent/US12097250B2/en active Active
- 2023-11-28 JP JP2023200623A patent/JP7587666B2/ja active Active
-
2024
- 2024-08-22 US US18/812,253 patent/US20240398925A1/en active Pending
- 2024-11-08 JP JP2024195537A patent/JP2025024036A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI3720483T3 (fi) | Streptococcus pneumoniaen polysakkaridi-proteiinikonjugaatteja käsittäviä koostumuksia ja niiden käyttömenetelmiä | |
| JOP20210148A1 (ar) | تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها | |
| BR112022001654A2 (pt) | Composições conjugadas de proteinas de polissacarídeos pneumocócicos multivalentes e métodos de utilização dos mesmos | |
| NZ755770A (en) | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof | |
| SA519401027B1 (ar) | تركيب متقارن من عديد السكاريد للمكورة الرئوية متعددة التكافؤ - وبروتين | |
| IL276229B2 (en) | Multivalent pneumococcal polysaccharide-protein conjugate composition | |
| JP2021505589A5 (https=) | ||
| MX2020002556A (es) | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. | |
| AR127517A2 (es) | Composición del conjugado proteína-polisacárido multivalente neumocócica | |
| JP2019526621A5 (https=) | ||
| MX2020002555A (es) | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. | |
| BR112018000087A2 (pt) | composições imunogênicas que compreendem antígenos de sacarídeos capsulares conjugados, kits que compreendem as mesmas e usos das mesmas | |
| BR112018007812A2 (pt) | polissacarídeo capsular, processo para preparar um polissacarídeo capsular e para fabricar uma vacina, composição imunogênica, vacina, métodos para tratamento ou prevenção de uma infecção, para imunizar um hospedeiro humano e para induzir uma resposta imune, e, uso de uma composição imunogênica. | |
| BR112019001995A2 (pt) | composição de conjugado de polissacarídeo pneumocócico multivalente ? proteína | |
| MY182282A (en) | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof | |
| BR112013012626A2 (pt) | formulação, composição imunogênica, e, seringa pré-carregada | |
| JP2019526620A5 (https=) | ||
| AR131123A1 (es) | Composiciones inmunógenas que comprenden antígenos de sacárido capsular conjugados y sus usos | |
| RU2021138121A (ru) | Способы лечения пациентов иммуногенной композицией, защищающей от серотипа 29 s. pneumoniae | |
| ZA202402956B (en) | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof | |
| EA202191647A1 (ru) | Композиции, содержащие конъюгаты полисахарида из streptococcus pneumoniae и белка, и способы их применения | |
| AR122291A1 (es) | Composiciones conjugadas neumocócicas multivalentes polisacárido - proteína y métodos para usar las mismas | |
| MX2024004116A (es) | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y formulacion de vacuna multivalente obtenida de los mismos | |
| TW202617178A (zh) | 多價肺炎球菌多醣-蛋白質共軛物組成物及使用其之方法 | |
| EA202091439A1 (ru) | Поливалентная противопневмококковая полисахаридно-белковая конъюгированная композиция |