BR112020011414B8 - Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae - Google Patents
Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniaeInfo
- Publication number
- BR112020011414B8 BR112020011414B8 BR112020011414A BR112020011414A BR112020011414B8 BR 112020011414 B8 BR112020011414 B8 BR 112020011414B8 BR 112020011414 A BR112020011414 A BR 112020011414A BR 112020011414 A BR112020011414 A BR 112020011414A BR 112020011414 B8 BR112020011414 B8 BR 112020011414B8
- Authority
- BR
- Brazil
- Prior art keywords
- pneumoniae
- immunogenic compositions
- protein
- multivalent immunogenic
- polysaccharide
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A invenção se refere a composições imunogênicas multivalentes compreendendo mais de um conjugado de proteína e polissacarídeo de S. pneumoniae, em que cada um dos conjugados compreende um polissacarídeo de um sorotipo de S. pneumoniae conjugado a uma proteína carreadora, em que os sorotipos de S. pneumoniae são conforme definidos na presente invenção. Em algumas modalidades, pelo menos um dos conjugados de proteína e polissacarídeo é formado por uma reação de conjugação compreendendo um solvente aprótico. Em modalidades adicionais, cada um dos conjugados de proteína e polissacarídeo é formado por uma reação de conjugação compreendendo um solvente aprótico. Também são fornecidos métodos para induzir uma resposta imune protetora em um paciente humano compreendendo administrar as composições imunogênicas multivalentes da invenção ao paciente. As composições imunogênicas multivalentes são úteis para fornecer proteção contra infecção por S. pneumoniae e doenças causadas por S. pneumoniae. As composições da invenção também são úteis como parte de regimes de tratamento que fornecem proteção complementar para pacientes que foram vacinados com uma vacina multivalente indicada para a prevenção de doença pneumocócica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762595388P | 2017-12-06 | 2017-12-06 | |
US62/595,388 | 2017-12-06 | ||
PCT/US2018/063709 WO2019139692A2 (en) | 2017-12-06 | 2018-12-04 | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112020011414A2 BR112020011414A2 (pt) | 2020-12-01 |
BR112020011414B1 BR112020011414B1 (pt) | 2022-09-27 |
BR112020011414B8 true BR112020011414B8 (pt) | 2023-01-31 |
Family
ID=66334525
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112020011414A BR112020011414B8 (pt) | 2017-12-06 | 2018-12-04 | Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae |
BR122021023687A BR122021023687A8 (pt) | 2017-12-06 | 2018-12-04 | Usos de composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122021023687A BR122021023687A8 (pt) | 2017-12-06 | 2018-12-04 | Usos de composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae |
Country Status (26)
Country | Link |
---|---|
US (4) | US20210177957A1 (pt) |
EP (1) | EP3720483A2 (pt) |
JP (3) | JP7369123B2 (pt) |
KR (3) | KR102573200B1 (pt) |
CN (2) | CN111683678B (pt) |
AR (2) | AR114154A1 (pt) |
AU (2) | AU2018400751B2 (pt) |
BR (2) | BR112020011414B8 (pt) |
CA (1) | CA3084436A1 (pt) |
CL (1) | CL2020001478A1 (pt) |
CO (1) | CO2020006882A2 (pt) |
CR (1) | CR20200245A (pt) |
EA (1) | EA202091382A1 (pt) |
EC (1) | ECSP20032085A (pt) |
GE (1) | GEP20227420B (pt) |
IL (1) | IL274954B (pt) |
JO (1) | JOP20200141A1 (pt) |
MA (2) | MA51049A (pt) |
MX (1) | MX2020005779A (pt) |
NI (1) | NI202000040A (pt) |
NZ (1) | NZ765694A (pt) |
PE (1) | PE20201338A1 (pt) |
PH (1) | PH12020550891A1 (pt) |
SG (1) | SG11202005255PA (pt) |
TW (1) | TWI725359B (pt) |
WO (1) | WO2019139692A2 (pt) |
Families Citing this family (24)
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RU2710393C2 (ru) * | 2014-01-21 | 2019-12-26 | Пфайзер Инк. | Способ получения иммуногенного конъюгата капсульный полисахарид Streptococcus pneumoniae-белок-носитель |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
MY192183A (en) * | 2015-07-21 | 2022-08-05 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
CN116870144A (zh) | 2017-01-31 | 2023-10-13 | 默沙东有限责任公司 | 制备多糖-蛋白缀合物的方法 |
BR112019017560A2 (pt) * | 2017-02-24 | 2020-04-07 | Merck Sharp & Dohme | intensificação da imunogenicidade dos conjugados de polissacarídeo-proteína de streptococcus pneumoniae |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
US11491216B2 (en) * | 2017-09-07 | 2022-11-08 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
MX2020002557A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
CN111093650B (zh) * | 2017-09-07 | 2024-03-01 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
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BR112020021296A2 (pt) | 2018-04-18 | 2021-01-26 | Sk Bioscience Co., Ltd. | polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo |
US11896656B2 (en) | 2018-04-30 | 2024-02-13 | Merck Sharp & Dohme Llc | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
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JOP20210148A1 (ar) | 2018-12-19 | 2023-01-30 | Merck Sharp & Dohme | تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها |
KR20220042378A (ko) | 2019-07-31 | 2022-04-05 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 및 그 사용 방법 |
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KR20230097160A (ko) | 2020-11-04 | 2023-06-30 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
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