BRPI0922981A8 - método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae - Google Patents
método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae Download PDFInfo
- Publication number
- BRPI0922981A8 BRPI0922981A8 BRPI0922981A BRPI0922981A8 BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8 BR PI0922981 A BRPI0922981 A BR PI0922981A BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8
- Authority
- BR
- Brazil
- Prior art keywords
- streptococcus pneumoniae
- fermentation culture
- molecular weight
- weight control
- addition
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
"método para o controle do peso molecular de polissacarídeo para o sorotipo 19a de streptococcus pneumoniae". a presente invenção refere-se a métodos melhorados para a produção de uma solução contendo polissacarídeos capsulares 19a de streptococcus pneumoniae isolado de alto peso molecular. em certos métodos, uma cultura de fermentação de células bacterianas de streptococcus pneumoniae que produzem polissacarídeos capsulares para o sorotipo 19a é fermentada durante menos do que 6 horas antes das células bacterianas serem submetidas à lise e os polissacarídeos capsulares são colhidos. em outros métodos, co2 é fornecido à cultura de fermentação. o fornecimento de co2 à cultura de fermentação inclui a adição de íons de bicarbonato na cultura de fermentação, a adição de íons de carbonato na cultura de fermentação, a adição de misturas de íons de bicarbonato e carbonato na cultura de fermentação, e sobreposição da cultura de fermentação com co2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13856308P | 2008-12-18 | 2008-12-18 | |
PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0922981A2 BRPI0922981A2 (pt) | 2015-08-25 |
BRPI0922981A8 true BRPI0922981A8 (pt) | 2019-11-26 |
Family
ID=42266457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0922981-7 BRPI0922981A8 (pt) | 2008-12-18 | 2009-12-17 | método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae |
Country Status (19)
Country | Link |
---|---|
US (1) | US8795689B2 (pt) |
EP (1) | EP2379734B1 (pt) |
JP (1) | JP5843612B2 (pt) |
KR (2) | KR20110091546A (pt) |
CN (1) | CN102257155B (pt) |
AU (1) | AU2009335826B2 (pt) |
BR (1) | BRPI0922981A8 (pt) |
CA (1) | CA2743710C (pt) |
DK (1) | DK2379734T3 (pt) |
ES (1) | ES2666698T3 (pt) |
HK (1) | HK1163750A1 (pt) |
HU (1) | HUE037465T2 (pt) |
IL (1) | IL213169A (pt) |
MX (1) | MX2011006432A (pt) |
PL (1) | PL2379734T3 (pt) |
PT (1) | PT2379734T (pt) |
RU (1) | RU2511404C2 (pt) |
SI (1) | SI2379734T1 (pt) |
WO (1) | WO2010080486A2 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009335824B2 (en) * | 2008-12-18 | 2013-07-04 | Wyeth Llc | Method for controlling Streptococcus pneumoniae polysaccharide molecular weight using carbon |
WO2010125480A1 (en) | 2009-04-30 | 2010-11-04 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
WO2013088448A1 (en) * | 2011-12-15 | 2013-06-20 | Serum Institute Of India Ltd. | A novel process of cultivating bacteria for yield improvement of capsular polyoses |
US9636392B2 (en) | 2012-09-07 | 2017-05-02 | Sk Chemical Co., Ltd. | Production method for capsular polysaccharide having pneumococcal serotype |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
WO2018126229A2 (en) | 2016-12-30 | 2018-07-05 | Sutrovax, Inc. | Polypeptide-antigen conjugates with non-natural amino acids |
CN116870144A (zh) | 2017-01-31 | 2023-10-13 | 默沙东有限责任公司 | 制备多糖-蛋白缀合物的方法 |
BR112019017560A2 (pt) | 2017-02-24 | 2020-04-07 | Merck Sharp & Dohme | intensificação da imunogenicidade dos conjugados de polissacarídeo-proteína de streptococcus pneumoniae |
BR112019026192B1 (pt) | 2017-06-10 | 2022-05-10 | Inventprise, Llc | Vacinas de conjugado multivalente com polissacarídeos de conjugado bivalente ou multivalente que fornecem imunogenicidade e avidez melhoradas |
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
MX2020002557A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
GEP20227420B (en) | 2017-12-06 | 2022-10-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
BR112020021296A2 (pt) * | 2018-04-18 | 2021-01-26 | Sk Bioscience Co., Ltd. | polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo |
EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | METHODS FOR PRODUCING CAPSULAR CARRIER PROTEIN-POLYSACCHARIDE CONJUGATES OF STREPTOCOCCUS PNEUMONIAE |
US11896656B2 (en) | 2018-04-30 | 2024-02-13 | Merck Sharp & Dohme Llc | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
JOP20210148A1 (ar) | 2018-12-19 | 2023-01-30 | Merck Sharp & Dohme | تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها |
Family Cites Families (25)
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CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
US5314822A (en) * | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
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JP5049264B2 (ja) * | 2005-04-08 | 2012-10-17 | ワイス・エルエルシー | pH操作によるストレプトコッカス・ニューモニエ多糖からの混入物の分離 |
US20070184072A1 (en) * | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
CL2007002909A1 (es) | 2006-10-10 | 2008-04-18 | Wyeth Corp | Metodo para reduccion o extraccion de impurezas de proteinas a partir de lisado celular de streptoccocus pneumoniae que comprende calentar dicho lisado, separar a los precipitantes a partir de dicho lisado produciendo un lisado que contiene polisacar |
US7860500B2 (en) * | 2006-10-27 | 2010-12-28 | Motorola, Inc. | Method and apparatus for determining appropriate channels for communication |
HUE039169T2 (hu) * | 2007-03-23 | 2018-12-28 | Wyeth Llc | Rövidített tisztítási eljárás Streptococcus pneumoniae tok-poliszacharidok elõállítására |
AU2009335824B2 (en) * | 2008-12-18 | 2013-07-04 | Wyeth Llc | Method for controlling Streptococcus pneumoniae polysaccharide molecular weight using carbon |
-
2009
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Application Discontinuation
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/en active
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active IP Right Grant
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en active Application Filing
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
-
2012
- 2012-04-24 HK HK12104021.1A patent/HK1163750A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IL213169A0 (en) | 2011-07-31 |
DK2379734T3 (en) | 2018-04-23 |
CA2743710C (en) | 2017-01-24 |
US8795689B2 (en) | 2014-08-05 |
SI2379734T1 (en) | 2018-05-31 |
ES2666698T3 (es) | 2018-05-07 |
PT2379734T (pt) | 2018-04-27 |
HK1163750A1 (zh) | 2012-09-14 |
WO2010080486A3 (en) | 2010-11-04 |
US20100158953A1 (en) | 2010-06-24 |
IL213169A (en) | 2015-02-26 |
JP5843612B2 (ja) | 2016-01-13 |
BRPI0922981A2 (pt) | 2015-08-25 |
AU2009335826B2 (en) | 2013-10-31 |
HUE037465T2 (hu) | 2018-09-28 |
WO2010080486A2 (en) | 2010-07-15 |
KR20110091546A (ko) | 2011-08-11 |
RU2511404C2 (ru) | 2014-04-10 |
RU2011128564A (ru) | 2013-01-27 |
AU2009335826A1 (en) | 2010-07-15 |
CN102257155A (zh) | 2011-11-23 |
PL2379734T3 (pl) | 2018-08-31 |
MX2011006432A (es) | 2011-09-29 |
CN102257155B (zh) | 2016-03-02 |
EP2379734B1 (en) | 2018-03-21 |
JP2012512660A (ja) | 2012-06-07 |
KR20130136011A (ko) | 2013-12-11 |
EP2379734A2 (en) | 2011-10-26 |
CA2743710A1 (en) | 2010-07-15 |
KR101593770B1 (ko) | 2016-02-15 |
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