BR112014019166A2 - promotores para expressão aumentada de proteína em meningococos - Google Patents

promotores para expressão aumentada de proteína em meningococos

Info

Publication number
BR112014019166A2
BR112014019166A2 BR112014019166A BR112014019166A BR112014019166A2 BR 112014019166 A2 BR112014019166 A2 BR 112014019166A2 BR 112014019166 A BR112014019166 A BR 112014019166A BR 112014019166 A BR112014019166 A BR 112014019166A BR 112014019166 A2 BR112014019166 A2 BR 112014019166A2
Authority
BR
Brazil
Prior art keywords
promoters
meningococci
protein expression
increased protein
rna
Prior art date
Application number
BR112014019166A
Other languages
English (en)
Inventor
Delany Isabel
Guadagnuolo Serafina
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014019166A2 publication Critical patent/BR112014019166A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/60—Vectors containing traps for, e.g. exons, promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

resumo “promotores para expressão aumentada de proteína em meningococos” são descritos novos promotores destinados a conduzir transcrição em meningococos, e.g., com o objetivo de superexpressão de antígenos protéicos para retenção em vesículas da membrana. há deficiência de promotores pora modificados na sequência poli-g do tipo selvagem que podem causar variação de fase. genes que codificam rrna meningocócico (e.g., para rna de 16s) podem ser usados para conduzir transcrição de um gene que codifica proteína. esses procedimentos podem ser usados em combinação.
BR112014019166A 2012-02-02 2013-02-01 promotores para expressão aumentada de proteína em meningococos BR112014019166A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261594159P 2012-02-02 2012-02-02
PCT/EP2013/052108 WO2013113917A1 (en) 2012-02-02 2013-02-01 Promoters for increased protein expression in meningococcus

Publications (1)

Publication Number Publication Date
BR112014019166A2 true BR112014019166A2 (pt) 2017-07-04

Family

ID=47683718

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019166A BR112014019166A2 (pt) 2012-02-02 2013-02-01 promotores para expressão aumentada de proteína em meningococos

Country Status (11)

Country Link
US (1) US9657297B2 (pt)
EP (2) EP3299467B1 (pt)
JP (2) JP5957541B2 (pt)
CN (1) CN104114706A (pt)
AU (1) AU2013214105A1 (pt)
BR (1) BR112014019166A2 (pt)
CA (1) CA2861946A1 (pt)
ES (1) ES2654613T3 (pt)
MX (1) MX2014008988A (pt)
RU (1) RU2014135522A (pt)
WO (1) WO2013113917A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61246B1 (sr) 2014-02-28 2021-01-29 Glaxosmithkline Biologicals Sa Modifikovani meningokokni fhbp polipeptidi
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
CN109485704B (zh) * 2018-11-27 2022-04-19 温州大学 一种脑膜炎球菌fHbp蛋白的表达系统
CN111321141B (zh) * 2018-12-14 2021-02-26 上海凯赛生物技术股份有限公司 稳定期特异性启动子及其应用
CN111850003A (zh) * 2020-07-09 2020-10-30 华中农业大学 一种重组表达的多杀性巴氏杆菌硫胺素周质结合蛋白及应用
CN114854701B (zh) * 2022-03-16 2023-09-22 福建福大百特生物科技有限公司 一种微泡菌超氧化物歧化酶及其编码基因

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Also Published As

Publication number Publication date
CN104114706A (zh) 2014-10-22
RU2014135522A (ru) 2016-03-27
WO2013113917A1 (en) 2013-08-08
JP2016093202A (ja) 2016-05-26
JP2015506693A (ja) 2015-03-05
EP3299467A2 (en) 2018-03-28
EP2809785B1 (en) 2017-11-01
EP3299467B1 (en) 2021-08-11
US20150218566A1 (en) 2015-08-06
CA2861946A1 (en) 2013-08-08
MX2014008988A (es) 2014-08-27
ES2654613T3 (es) 2018-02-14
JP5957541B2 (ja) 2016-07-27
AU2013214105A1 (en) 2014-07-24
US9657297B2 (en) 2017-05-23
EP2809785A1 (en) 2014-12-10
EP3299467A3 (en) 2018-05-30

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2447 DE 28-11-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.