FI104836B - Förfarande för framställning av aminosyror genom fermentering - Google Patents
Förfarande för framställning av aminosyror genom fermentering Download PDFInfo
- Publication number
- FI104836B FI104836B FI924146A FI924146A FI104836B FI 104836 B FI104836 B FI 104836B FI 924146 A FI924146 A FI 924146A FI 924146 A FI924146 A FI 924146A FI 104836 B FI104836 B FI 104836B
- Authority
- FI
- Finland
- Prior art keywords
- fermentation
- amino acids
- content
- strain
- medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (5)
1. Förfarande för framställning av aminosyror genom fermentering, i vilket förfarande en stam av släktet Bre-5 vibacterium eller Corynebacterium som producerar en eller flera aminosyror odlas i ett näringsmedium ooh vid slutet av fermenteringen isoleras aminosyran eller aminosyrorna ur odlingslösningen, kännetecknat av att bak-terieodlingen omedelbart efter den logaritmiska tillväxt-10 fasen har en mindre mängd av assimilerbar kolkalla tili sitt förfogande än vad den kunde metabolisera pä basen av stammens karaktär och mängden av övriga nödvändiga komp-letterande näringsämnen som tillsatts tili näringsmediet, och halten av kolkalla är 0 - <3 g/1. 15
2. Förfarande enligt patentkrav 1, känne tecknat av att man använder auxotrofa bakteriestam-mar och koncentrationen av ätminstone en organisk förening som tillsatts pä basen av stammens enkla eller mängfaldiga auxotrofi begränsas efter den logaritmiska tillväxtfasen 20 tili ett omräde av 0 - 0,1 g/1.
3. Förfarande enligt patentkrav 1 eller 2, kä n -netecknat av att man använder stammar som producerar L-lysin och/eller L-treonin.
4. Förfarande enligt patentkrav 3, k ä n n e - . 25 tecknat av att man använder leucin-auxotrofa stam mar av Corynebacterium glutamicum.
5. Förfarande enligt patentkrav 4, kännetecknat av att bildningen av biomassa begränsas genom leucin-utbudet. •« «
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4130867 | 1991-09-17 | ||
DE4130867A DE4130867A1 (de) | 1991-09-17 | 1991-09-17 | Verfahren zur fermentativen herstellung von aminosaeuren |
Publications (3)
Publication Number | Publication Date |
---|---|
FI924146A0 FI924146A0 (fi) | 1992-09-16 |
FI924146A FI924146A (fi) | 1993-03-18 |
FI104836B true FI104836B (sv) | 2000-04-14 |
Family
ID=6440783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI924146A FI104836B (sv) | 1991-09-17 | 1992-09-16 | Förfarande för framställning av aminosyror genom fermentering |
Country Status (20)
Country | Link |
---|---|
US (1) | US5770409A (sv) |
EP (1) | EP0532867B1 (sv) |
JP (1) | JP2965799B2 (sv) |
KR (1) | KR100254023B1 (sv) |
CN (1) | CN1038693C (sv) |
AT (1) | ATE149571T1 (sv) |
AU (1) | AU656416B2 (sv) |
BR (1) | BR9203587A (sv) |
CA (1) | CA2078364C (sv) |
CZ (1) | CZ263392A3 (sv) |
DE (2) | DE4130867A1 (sv) |
DK (1) | DK0532867T3 (sv) |
ES (1) | ES2098398T3 (sv) |
FI (1) | FI104836B (sv) |
GR (1) | GR3023364T3 (sv) |
MX (1) | MX9205248A (sv) |
RU (1) | RU2107097C1 (sv) |
SK (1) | SK279888B6 (sv) |
TW (1) | TW206984B (sv) |
UA (1) | UA27034C2 (sv) |
Families Citing this family (65)
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DE19547361A1 (de) * | 1995-12-19 | 1997-06-26 | Degussa | Verfahren zur Herstellung von L-Aminosäuren durch Fermentation |
CA2255130A1 (en) | 1997-12-16 | 1999-06-16 | Archer Daniels Midland Company | Process for making granular l-lysine feed supplement |
DE10021828A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cdsA-Gen kodierende Nukleotidsequenzen |
DE10021832A1 (de) * | 2000-05-04 | 2001-11-08 | Degussa | Neue für das cma-Gen kodierende Nukleotidsequenzen |
JP4362959B2 (ja) * | 2000-08-24 | 2009-11-11 | 味の素株式会社 | 塩基性アミノ酸の製造方法 |
JP2002284749A (ja) | 2001-03-23 | 2002-10-03 | Ajinomoto Co Inc | 塩基性アミノ酸溶液の製造方法 |
US7718361B2 (en) | 2002-12-06 | 2010-05-18 | Roche Molecular Systems, Inc. | Quantitative test for bacterial pathogens |
US20040115304A1 (en) * | 2002-12-16 | 2004-06-17 | Frank Dubner | Feesdstuffs additives containing L-lysine with improved abrasion resistance, and process for their production |
WO2005021773A1 (en) * | 2003-08-29 | 2005-03-10 | Degussa Ag | Process for the preparation of l-lysine |
WO2005021772A1 (en) * | 2003-08-29 | 2005-03-10 | Degussa Ag | Process for the preparation of l-lysine |
WO2005021771A2 (en) * | 2003-08-29 | 2005-03-10 | Degussa Ag | Process for the production of l-lysine |
DE102004026152A1 (de) | 2004-05-28 | 2005-12-15 | Basf Ag | Fermentative Herstellung von Feinchemikalien |
PL2818556T3 (pl) | 2004-10-07 | 2023-07-17 | Ajinomoto Co., Inc. | Sposób wytwarzania zasadowej substancji |
DE102005032429A1 (de) | 2005-01-19 | 2006-07-20 | Degussa Ag | Allele des mqo-Gens aus coryneformen Bakterien |
CN100371437C (zh) * | 2005-02-01 | 2008-02-27 | 湛江海洋大学 | 生产复合氨基酸的地衣芽孢杆菌菌株及养殖用氨基酸液肥制备方法 |
DE102005013676A1 (de) | 2005-03-24 | 2006-09-28 | Degussa Ag | Allele des zwf-Gens aus coryneformen Bakterien |
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US20070082031A1 (en) | 2005-10-08 | 2007-04-12 | Hermann Lotter | L-lysine-containing feed additives |
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DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
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DE102011006716A1 (de) | 2011-04-04 | 2012-10-04 | Evonik Degussa Gmbh | Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung |
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RU2486248C2 (ru) * | 2011-06-29 | 2013-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет инженерной экологии" (ФГБОУ ВПО "МГУИЭ") | Способ биосинтеза l-лизина |
EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
PL2841568T3 (pl) | 2012-04-27 | 2018-07-31 | Evonik Technochemie Gmbh | Odporne na sprzężenie zwrotne syntazy alfa-izopropylojabłczanowe |
BR112014027768A2 (pt) | 2012-05-09 | 2017-06-27 | Evonik Industries Ag | aditivo de ração animal, contendo l-aminoácido, na forma de um granulado na base de caldo de fermentação e processo para produção |
ES2689754T3 (es) | 2012-08-20 | 2018-11-15 | Evonik Degussa Gmbh | Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae |
DE102012024435A1 (de) | 2012-12-14 | 2014-07-10 | Forschungszentrum Jülich GmbH | Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
PL2811028T3 (pl) | 2013-06-03 | 2017-07-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-waliny z zastosowaniem zrekombinowanych bakterii maczugowatych zawierających operon ilvBN indukowany propionianem |
EP2865274B1 (de) | 2013-10-24 | 2020-03-04 | Evonik Operations GmbH | L-Aminosäure enthaltendes Futtermitteladditiv |
DK2865275T3 (da) | 2013-10-24 | 2020-05-18 | Evonik Operations Gmbh | Foderstofadditiv indeholdende L-aminosyre |
EP2940143B1 (de) | 2014-04-30 | 2020-02-05 | Evonik Operations GmbH | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
EP2940039A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems |
EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
CA3007635A1 (en) | 2015-12-07 | 2017-06-15 | Zymergen Inc. | Promoters from corynebacterium glutamicum |
US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
JP2019062742A (ja) | 2016-02-24 | 2019-04-25 | 味の素株式会社 | L−アミノ酸の製造法 |
WO2018005793A1 (en) | 2016-06-30 | 2018-01-04 | Zymergen Inc. | Methods for generating a glucose permease library and uses thereof |
EP3478833A4 (en) | 2016-06-30 | 2019-10-02 | Zymergen, Inc. | METHODS OF GENERATING A BACTERIAL HEMOGLOBIN LIBRARY AND USES THEREOF |
CN111601897A (zh) | 2016-12-30 | 2020-08-28 | 奎多公司 | 用于确定细菌对抗生素或益菌剂的易感性的噬菌体介导的免疫分析和方法 |
CN110869504A (zh) | 2017-06-07 | 2020-03-06 | 齐默尔根公司 | 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途 |
EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
CN108018325B (zh) * | 2017-08-23 | 2020-10-09 | 江南大学 | 提高谷胱甘肽产量的方法 |
EP3456833A1 (en) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
WO2019070612A1 (en) | 2017-10-02 | 2019-04-11 | Quidel Corporation | PHAGE-BASED DETECTION METHOD FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING AND IDENTIFICATION OF BACTERIAL SPECIES |
EP3467099A1 (en) | 2017-10-05 | 2019-04-10 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
EP3498853A1 (en) | 2017-12-14 | 2019-06-19 | Evonik Degussa GmbH | Method for the fermentative production of l-lysine |
EP3594355A1 (en) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
EP3599282B1 (en) | 2018-07-24 | 2021-03-17 | Evonik Operations GmbH | Method for the fermentative production of l-lysine |
RU2019128538A (ru) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | Способ ферментативного получения l-лизина |
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US20230340428A1 (en) | 2020-07-15 | 2023-10-26 | Evonik Operations Gmbh | Polynucleotide encoding an amino acid sequence, encoding an oxidoreductase |
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CN117957242A (zh) | 2021-08-09 | 2024-04-30 | 赢创运营有限公司 | 编码细菌胶原样蛋白的多核苷酸 |
CN117999103A (zh) | 2021-09-20 | 2024-05-07 | 赢创运营有限公司 | 非粘附性胶原蛋白样水凝胶 |
EP4405376A1 (en) | 2021-09-20 | 2024-07-31 | Evonik Operations GmbH | Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2 |
KR20230056095A (ko) | 2021-10-19 | 2023-04-27 | 씨제이제일제당 (주) | 아미노산 발효 공정에서 발생한 고농도 발효 부산물의 처리방법 |
WO2023161038A1 (en) | 2022-02-25 | 2023-08-31 | Evonik Operations Gmbh | Sponges based on collagen-like proteins |
WO2023165952A1 (en) | 2022-03-01 | 2023-09-07 | Evonik Operations Gmbh | Biotechnological production of collagen proteins and bacterial collagen-like proteins by recombinant microorganisms |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE269167C (sv) * | ||||
FR2488273A1 (fr) * | 1980-08-07 | 1982-02-12 | Inst Mikrobiologii Im Avg | Procede microbiologique de preparation de l-lysine et l-lysine obtenue par ledit procede |
JPS57115186A (en) * | 1980-12-29 | 1982-07-17 | Ajinomoto Co Inc | Preparation of l-lysine by fermentation |
SU1157059A1 (ru) * | 1983-02-28 | 1985-05-23 | Белорусский Ордена Трудового Красного Знамени Технологический Институт Им.С.М.Кирова | Способ получени @ -лизина |
DD268834A3 (de) * | 1983-06-03 | 1989-06-14 | Ve Forschungszentrum Biotechno | Verfahren zur fermentativen herstellung von l-lysin |
FR2604447B1 (fr) * | 1986-09-29 | 1989-05-19 | Ajinomoto Kk | Procede de production de l-threonine par fermentation |
DD269167A1 (de) * | 1987-07-30 | 1989-06-21 | Ve Forschungszentrum Biotechno | Verfahren zur mikrobiologischen herstellung von l-lysin |
KR910002850B1 (ko) * | 1989-03-30 | 1991-05-06 | 제일제당 주식회사 | L-라이신을 생산하는 미생물 및 이를 이용한 l-라이신의 제조방법 |
AU5600590A (en) * | 1989-06-01 | 1990-12-06 | Unisearch Limited | High lysine producing microorganisms |
-
1991
- 1991-09-17 DE DE4130867A patent/DE4130867A1/de not_active Withdrawn
-
1992
- 1992-07-29 AT AT92112903T patent/ATE149571T1/de active
- 1992-07-29 DE DE59208102T patent/DE59208102D1/de not_active Expired - Lifetime
- 1992-07-29 ES ES92112903T patent/ES2098398T3/es not_active Expired - Lifetime
- 1992-07-29 DK DK92112903.7T patent/DK0532867T3/da active
- 1992-07-29 EP EP92112903A patent/EP0532867B1/de not_active Expired - Lifetime
- 1992-08-26 CZ CS922633A patent/CZ263392A3/cs unknown
- 1992-08-26 SK SK2633-92A patent/SK279888B6/sk not_active IP Right Cessation
- 1992-09-15 MX MX9205248A patent/MX9205248A/es unknown
- 1992-09-15 BR BR929203587A patent/BR9203587A/pt not_active Application Discontinuation
- 1992-09-16 RU SU5052640A patent/RU2107097C1/ru not_active IP Right Cessation
- 1992-09-16 FI FI924146A patent/FI104836B/sv not_active IP Right Cessation
- 1992-09-16 CA CA002078364A patent/CA2078364C/en not_active Expired - Fee Related
- 1992-09-16 CN CN92110718A patent/CN1038693C/zh not_active Expired - Lifetime
- 1992-09-16 AU AU24559/92A patent/AU656416B2/en not_active Ceased
- 1992-09-17 JP JP4247942A patent/JP2965799B2/ja not_active Expired - Lifetime
- 1992-09-17 KR KR1019920016885A patent/KR100254023B1/ko not_active IP Right Cessation
- 1992-10-13 TW TW081108136A patent/TW206984B/zh not_active IP Right Cessation
-
1993
- 1993-06-10 UA UA93002075A patent/UA27034C2/uk unknown
-
1996
- 1996-07-10 US US08/677,911 patent/US5770409A/en not_active Expired - Lifetime
-
1997
- 1997-05-09 GR GR970401016T patent/GR3023364T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
SK279888B6 (sk) | 1999-05-07 |
US5770409A (en) | 1998-06-23 |
KR100254023B1 (ko) | 2000-04-15 |
EP0532867A1 (de) | 1993-03-24 |
FI924146A (fi) | 1993-03-18 |
ES2098398T3 (es) | 1997-05-01 |
GR3023364T3 (en) | 1997-08-29 |
UA27034C2 (uk) | 2000-02-28 |
FI924146A0 (fi) | 1992-09-16 |
JPH05244969A (ja) | 1993-09-24 |
CA2078364C (en) | 2003-05-06 |
ATE149571T1 (de) | 1997-03-15 |
AU656416B2 (en) | 1995-02-02 |
CA2078364A1 (en) | 1993-03-18 |
CZ263392A3 (en) | 1993-04-14 |
BR9203587A (pt) | 1993-04-13 |
JP2965799B2 (ja) | 1999-10-18 |
DK0532867T3 (da) | 1997-07-28 |
DE59208102D1 (de) | 1997-04-10 |
AU2455992A (en) | 1993-03-18 |
MX9205248A (es) | 1993-05-01 |
RU2107097C1 (ru) | 1998-03-20 |
KR930006157A (ko) | 1993-04-20 |
SK263392A3 (en) | 1996-01-10 |
EP0532867B1 (de) | 1997-03-05 |
DE4130867A1 (de) | 1993-03-18 |
CN1070687A (zh) | 1993-04-07 |
CN1038693C (zh) | 1998-06-10 |
TW206984B (sv) | 1993-06-01 |
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