ES8503654A1 - Un procedimiento para la preparacion de una 1,4-dihidro-piridina. - Google Patents

Un procedimiento para la preparacion de una 1,4-dihidro-piridina.

Info

Publication number
ES8503654A1
ES8503654A1 ES520389A ES520389A ES8503654A1 ES 8503654 A1 ES8503654 A1 ES 8503654A1 ES 520389 A ES520389 A ES 520389A ES 520389 A ES520389 A ES 520389A ES 8503654 A1 ES8503654 A1 ES 8503654A1
Authority
ES
Spain
Prior art keywords
compound
formula
amino group
ischaemic
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520389A
Other languages
English (en)
Other versions
ES520389A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp
Original Assignee
Pfizer Corp Belgium
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10528947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8503654(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Corp Belgium, Pfizer Corp filed Critical Pfizer Corp Belgium
Publication of ES8503654A1 publication Critical patent/ES8503654A1/es
Publication of ES520389A0 publication Critical patent/ES520389A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA 1,4-DIHIDROPIRIDINA.CONSISTE EN: A) SOMETER UN COMPUESTO DE FORMULA (II) A UNA REACCION DE DESPROTECCION DEL GRUPO AMINO. SE REALIZA POR HIDROGENACION CATALICA, EN PRESENCIA DE ACIDOS Y EN DISOLVENTES ADECUADOS; Y B) HACER REACCIONAR AL COMPUESTO OBTENIDO EN LA ETAPA A) DONDE R ES H, CON UN COMPUESTO DE FORMULA (III), PARA DAR UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. SIENDO: Y, -(CH2)2-, (CH2)3-, Y OTROS; R, ARILO O HETEROARILO; HAL, BR O CL; R Y R INDEPENDIENTES ENTRE SI, ALQUILO C 1 A 4 O 2-METOXIETILO; Y R, -(CH2)M-COO (ALQUILO C 1 A 4); M, 1, 2 O 3; Y X, UN GRUPO AMINO PRIMARIO O SECUNDARIO PROTEGIDO, SIENDO EL CITADO GRUPO AMINO SECUNDARIO -NHR.SE UTILIZAN COMO AGENTES ANTI-ISQUEMICOS Y ANTIHIPERTENSIVOS.
ES520389A 1982-03-11 1983-03-08 Un procedimiento para la preparacion de una 1,4-dihidro-piridina. Granted ES520389A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8207180 1982-03-11

Publications (2)

Publication Number Publication Date
ES8503654A1 true ES8503654A1 (es) 1985-03-16
ES520389A0 ES520389A0 (es) 1985-03-16

Family

ID=10528947

Family Applications (2)

Application Number Title Priority Date Filing Date
ES520389A Granted ES520389A0 (es) 1982-03-11 1983-03-08 Un procedimiento para la preparacion de una 1,4-dihidro-piridina.
ES526459A Expired ES8505201A1 (es) 1982-03-11 1983-10-14 Un procedimiento para la preparacion de una 1,4-dihidropiridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526459A Expired ES8505201A1 (es) 1982-03-11 1983-10-14 Un procedimiento para la preparacion de una 1,4-dihidropiridina

Country Status (37)

Country Link
US (1) US4572909A (es)
EP (1) EP0089167B1 (es)
JP (1) JPS58167569A (es)
KR (1) KR870000809B1 (es)
AT (1) ATE22884T1 (es)
AU (1) AU540769B2 (es)
BA (2) BA97147B1 (es)
BG (1) BG60658B2 (es)
CA (1) CA1253865A (es)
CS (3) CS240954B2 (es)
DD (2) DD218887A5 (es)
DE (2) DE3366920D1 (es)
DK (1) DK161312C (es)
EG (1) EG16987A (es)
ES (2) ES520389A0 (es)
FI (1) FI81090C (es)
GR (1) GR77429B (es)
HK (1) HK16288A (es)
HR (2) HRP930369B1 (es)
HU (1) HU187868B (es)
IE (2) IE54765B1 (es)
IL (1) IL68091A (es)
KE (1) KE3778A (es)
LU (1) LU88332I2 (es)
LV (2) LV5236A3 (es)
MY (1) MY101985A (es)
NL (1) NL930063I2 (es)
NO (3) NO162818C (es)
NZ (1) NZ203521A (es)
PL (3) PL140278B1 (es)
PT (1) PT76370B (es)
SG (1) SG98687G (es)
SI (2) SI8310586A8 (es)
SU (2) SU1238730A3 (es)
UA (2) UA7082A1 (es)
YU (2) YU43541B (es)
ZA (1) ZA831651B (es)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
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