ES2060547A1 - Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina". - Google Patents

Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".

Info

Publication number
ES2060547A1
ES2060547A1 ES09300928A ES9300928A ES2060547A1 ES 2060547 A1 ES2060547 A1 ES 2060547A1 ES 09300928 A ES09300928 A ES 09300928A ES 9300928 A ES9300928 A ES 9300928A ES 2060547 A1 ES2060547 A1 ES 2060547A1
Authority
ES
Spain
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
hydrogen
benzylpiperidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300928A
Other languages
English (en)
Other versions
ES2060547B1 (es
Inventor
Ambros Rafael Foguet
Gener Jordi Bolos
Mu Oz Aurelio Sacristan
Hernandez Jose A Ortiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9201158A external-priority patent/ES2043557B1/es
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES09300928A priority Critical patent/ES2060547B1/es
Priority to CA002096611A priority patent/CA2096611C/en
Priority to PH46253A priority patent/PH30422A/en
Priority to EP93108693A priority patent/EP0572952A1/en
Priority to JP5133582A priority patent/JP2610384B2/ja
Priority to KR1019930010133A priority patent/KR0128229B1/ko
Priority to US08/071,265 priority patent/US5395841A/en
Publication of ES2060547A1 publication Critical patent/ES2060547A1/es
Publication of ES2060547B1 publication Critical patent/ES2060547B1/es
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
    • H01L2224/01—Means for bonding being attached to, or being formed on, the surface to be connected, e.g. chip-to-package, die-attach, "first-level" interconnects; Manufacturing methods related thereto
    • H01L2224/42—Wire connectors; Manufacturing methods related thereto
    • H01L2224/47—Structure, shape, material or disposition of the wire connectors after the connecting process
    • H01L2224/48—Structure, shape, material or disposition of the wire connectors after the connecting process of an individual wire connector
    • H01L2224/4805—Shape
    • H01L2224/4809—Loop shape
    • H01L2224/48091—Arched
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
    • H01L2224/01—Means for bonding being attached to, or being formed on, the surface to be connected, e.g. chip-to-package, die-attach, "first-level" interconnects; Manufacturing methods related thereto
    • H01L2224/42—Wire connectors; Manufacturing methods related thereto
    • H01L2224/47—Structure, shape, material or disposition of the wire connectors after the connecting process
    • H01L2224/48—Structure, shape, material or disposition of the wire connectors after the connecting process of an individual wire connector
    • H01L2224/481—Disposition
    • H01L2224/48151—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive
    • H01L2224/48221—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked
    • H01L2224/48245—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked the item being metallic
    • H01L2224/48247—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked the item being metallic connecting the wire to a bond pad of the item

Abstract

MEJORAS EN EL OBJETO DE LA PATENTE DE INVENCION N.G 9201158 QUE SE REFIERE A PROCEDIMIENTO DE OBTENCION DE NUEVOS DERIVADOS DE LA 4-BENCILPIPERIDINA. CONSISTE EN EL TRATAMIENTO DEL COMPUESTO DE FORMULA (I'') DONDE X ES FLUOR Y R ES P-FLUOROFENOXI CON UNA SOLUCION DE UN CARBONATO O BICARBONATO ALCALINO, SEGUIDO DE EXTRACCION, SUBSIGUIENTE EVAPORACION DE LOS EXTRACTOS Y ADICION DE UNA SOLUCION DE HC1 EN ETER SOBRE EL RESIDUO SUSPENDIDO EN UNA MEZCLA DE UN ALCANOL CUYO NUMERO DE CARBONOS ES CUATRO COMO MAXIMO Y ETER. EL COMPUESTO DE FORMULA (I'') TIENE APLICACION FARMACOLOGICA POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES09300928A 1992-06-04 1993-05-03 Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina". Expired - Fee Related ES2060547B1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES09300928A ES2060547B1 (es) 1992-06-04 1993-05-03 Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
CA002096611A CA2096611C (en) 1992-06-04 1993-05-19 4-benzylpiperidine derivatives and process for their production
PH46253A PH30422A (en) 1992-06-04 1993-05-27 4-Benzylpiperidines for treating psychosis
EP93108693A EP0572952A1 (en) 1992-06-04 1993-05-28 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them
JP5133582A JP2610384B2 (ja) 1992-06-04 1993-06-03 ４−ベンジルピペリジン誘導体、その製造法及び該誘導体を含んで成る製剤組成物
KR1019930010133A KR0128229B1 (ko) 1992-06-04 1993-06-04 4-벤질피페리딘 유도체 및 이의 약제학적으로 허용하는 염, 및 이들의 제조방법
US08/071,265 US5395841A (en) 1992-06-04 1993-06-04 4-benzylpiperidines for treating phychosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9201158A ES2043557B1 (es) 1992-06-04 1992-06-04 Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.
ES09300928A ES2060547B1 (es) 1992-06-04 1993-05-03 Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".

Publications (2)

Publication Number Publication Date
ES2060547A1 true ES2060547A1 (es) 1994-11-16
ES2060547B1 ES2060547B1 (es) 1995-06-16

Family

ID=26154629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300928A Expired - Fee Related ES2060547B1 (es) 1992-06-04 1993-05-03 Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".

Country Status (7)

Country Link
US (1) US5395841A (es)
EP (1) EP0572952A1 (es)
JP (1) JP2610384B2 (es)
KR (1) KR0128229B1 (es)
CA (1) CA2096611C (es)
ES (1) ES2060547B1 (es)
PH (1) PH30422A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2066721B1 (es) * 1993-05-18 1996-02-16 Ferrer Int Nuevos compuestos derivados de la piridina 1,4-disustituida.
WO1995024390A1 (en) * 1994-03-11 1995-09-14 Smithkline Beecham Plc Novel phenyl(-alkyl/alkoxy)-1-aminoalkyl-substituted piperidines and pyrrolidines as calcium channel antagonists
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
FR2722497B1 (fr) * 1994-07-13 1996-08-14 Synthelabo Esters de alpha-4-chlorophenyl)-4-(4-fluorophenyl)methyl) piperidine-1-ethanol, leur preparation et leur application en therapeutique
FR2742051B1 (fr) * 1995-12-06 1998-02-06 Synthelabo Utilisation de composes ayant une affinite pour le site de liaison du (3h)ifenprodil pour la fabrication de medicaments utiles dans la prevention et le traitement des neuropathies
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
KR100746072B1 (ko) * 2000-12-29 2007-08-06 엘지전자 주식회사 김치 전용고의 숙성 제어장치 및 방법
KR20020079275A (ko) * 2001-04-14 2002-10-19 김익홍 김치냉장고의 표준온도 보정방법
GB0203778D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
KR20060024618A (ko) * 2004-09-14 2006-03-17 위니아만도 주식회사 김치저장고의 김치맛 표시 방법
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077427A1 (fr) * 1981-10-15 1983-04-27 Synthelabo Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
EP0288563A1 (en) * 1986-09-30 1988-11-02 Eisai Co., Ltd. Cyclic amine derivatives
EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US4588728A (en) * 1985-03-27 1986-05-13 Burroughs Wellcome Co. Treatment of drug induced psychosis
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
US4929734A (en) * 1987-03-31 1990-05-29 Warner-Lambert Company Tetrahydropyridine oxime compounds
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
US4981870A (en) * 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
EP0591426A4 (en) * 1991-06-27 1996-08-21 Univ Virginia Commonwealth Sigma receptor ligands and the use thereof
FR2681319B1 (fr) * 1991-09-12 1995-02-17 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077427A1 (fr) * 1981-10-15 1983-04-27 Synthelabo Dérivés de pipéridine, leur procédé de préparation et leur application en thérapeutique
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
EP0288563A1 (en) * 1986-09-30 1988-11-02 Eisai Co., Ltd. Cyclic amine derivatives
EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
EP0572952A1 (en) 1993-12-08
JP2610384B2 (ja) 1997-05-14
ES2060547B1 (es) 1995-06-16
US5395841A (en) 1995-03-07
CA2096611C (en) 1998-05-19
PH30422A (en) 1997-05-09
JPH06172308A (ja) 1994-06-21
KR0128229B1 (ko) 1998-04-02
CA2096611A1 (en) 1993-12-05
KR940005572A (ko) 1994-03-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528