ES2655540T3 - Inhibidores de factor XIa macrocíclicos condensados con heterociclos - Google Patents
Inhibidores de factor XIa macrocíclicos condensados con heterociclos Download PDFInfo
- Publication number
- ES2655540T3 ES2655540T3 ES15705427.1T ES15705427T ES2655540T3 ES 2655540 T3 ES2655540 T3 ES 2655540T3 ES 15705427 T ES15705427 T ES 15705427T ES 2655540 T3 ES2655540 T3 ES 2655540T3
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- independently selected
- chf2
- pharmaceutically acceptable
- alkyl
- tautomer
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US201461933948P | 2014-01-31 | ||
| PCT/US2015/013647 WO2015116882A1 (en) | 2014-01-31 | 2015-01-30 | Macrocyclic factor xia inhibitors condensed with heterocycles |
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| PH12014500625B1 (en) | 2011-10-14 | 2018-12-12 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
| SI3099687T1 (en) | 2014-01-31 | 2018-08-31 | Bristol-Myers Squibb Company | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
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| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| EP3310777B1 (en) | 2015-06-19 | 2019-10-09 | Bristol-Myers Squibb Company | Diamide macrocycles as factor xia inhibitors |
| EP3328851B1 (en) | 2015-07-29 | 2020-04-22 | Bristol-Myers Squibb Company | Factor xia macrocyclic inhibitors bearing alkyl or cycloalkyl p2' moieties |
| CN107922393A (zh) | 2015-07-29 | 2018-04-17 | 百时美施贵宝公司 | 携带非芳族p2,基团的因子xia新大环 |
| MX387515B (es) * | 2015-10-29 | 2025-03-18 | Merck Sharp & Dohme Llc | Inhibidores de factor xia. |
| WO2017074833A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
| CN109195973A (zh) | 2016-03-02 | 2019-01-11 | 百时美施贵宝公司 | 具有因子xia抑制活性的二酰胺大环类化合物 |
| EP3500556B1 (en) | 2016-08-22 | 2023-08-02 | Merck Sharp & Dohme LLC | Pyridine-1-oxide derivatives and their use as factor xia inhibitors |
| ES2837396T3 (es) | 2016-11-23 | 2021-06-30 | Bayer Cropscience Ag | Derivados de 2-[3-(alquilsulfonil)-2H-indazol-2-il]-3H-imidazo[4,5-b]piridina y compuestos similares como pesticidas |
| AU2018207776B2 (en) | 2017-01-10 | 2021-06-17 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| US11083199B2 (en) | 2017-01-10 | 2021-08-10 | Bayer Aktiengesellschaft | Heterocycle derivatives as pesticides |
| WO2018133793A1 (zh) * | 2017-01-18 | 2018-07-26 | 广东东阳光药业有限公司 | 凝血因子XIa抑制剂及其用途 |
| CN110922412A (zh) * | 2018-09-20 | 2020-03-27 | 复旦大学 | 具有抗精神病作用药物化合物的不对称合成方法 |
| CN113677682B (zh) * | 2019-04-16 | 2023-05-30 | 华润生物医药有限公司 | 作为XIa因子抑制剂的大环衍生物 |
| US20210041711A1 (en) * | 2019-07-08 | 2021-02-11 | Gary Sharp Innovations, Llc | Compact Polarization-Based Collimators with High Contrast |
| CN114008047B (zh) * | 2019-07-23 | 2023-03-21 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
| TW202229280A (zh) * | 2020-10-12 | 2022-08-01 | 美商必治妥美雅史谷比公司 | （６ｒ，１０ｓ）－１０－｛４－［５－氯－２－（４－氯－１ｈ－１，２，３－三唑－１－基）苯基］－６－側氧基－１（６ｈ）－嘧啶基｝－１－（二氟甲基）－６－甲基－１，４，７，８，９，１０－六氫－１１，１５－（亞甲橋基）吡唑并［４，３－ｂ］［１，７］二氮雜環十四炔－５（６ｈ）－酮之製備方法 |
| TWI877478B (zh) * | 2021-04-21 | 2025-03-21 | 大陸商上海美悦生物科技發展有限公司 | FXIa抑制劑及其藥物組合物、製備方法和用途 |
| TW202515882A (zh) * | 2023-06-30 | 2025-04-16 | 大陸商深圳信立泰藥業股份有限公司 | 一種多取代的大環化合物及其製備方法與應用 |
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-
2012
- 2012-08-31 NO NO12780535A patent/NO2760821T3/no unknown
-
2015
- 2015-01-30 RS RS20180033A patent/RS56785B1/sr unknown
- 2015-01-30 AR ARP150100295A patent/AR099228A1/es unknown
- 2015-01-30 CA CA2937738A patent/CA2937738C/en active Active
- 2015-01-30 HU HUE15705427A patent/HUE038060T2/hu unknown
- 2015-01-30 CN CN201580017759.3A patent/CN106459051B/zh active Active
- 2015-01-30 US US15/115,319 patent/US20170057961A1/en not_active Abandoned
- 2015-01-30 PT PT157054271T patent/PT3099688T/pt unknown
- 2015-01-30 SI SI201530121T patent/SI3099688T1/sl unknown
- 2015-01-30 SM SM20180024T patent/SMT201800024T1/it unknown
- 2015-01-30 BR BR112016016741-4A patent/BR112016016741B1/pt active IP Right Grant
- 2015-01-30 WO PCT/US2015/013647 patent/WO2015116882A1/en not_active Ceased
- 2015-01-30 EP EP15705427.1A patent/EP3099688B1/en active Active
- 2015-01-30 TW TW104103315A patent/TWI703144B/zh active
- 2015-01-30 ES ES15705427.1T patent/ES2655540T3/es active Active
- 2015-01-30 DK DK15705427.1T patent/DK3099688T3/en active
- 2015-01-30 PL PL15705427T patent/PL3099688T3/pl unknown
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- 2015-01-30 EA EA201691561A patent/EA032650B1/ru not_active IP Right Cessation
- 2015-01-30 LT LTEP15705427.1T patent/LT3099688T/lt unknown
- 2015-01-30 JP JP2016549270A patent/JP6419836B2/ja active Active
- 2015-01-30 HR HRP20172002TT patent/HRP20172002T1/hr unknown
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2017
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- 2017-12-29 CY CY20171101357T patent/CY1120534T1/el unknown
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2018
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| US10273236B2 (en) | 2019-04-30 |
| CY1120534T1 (el) | 2019-07-10 |
| RS56785B1 (sr) | 2018-04-30 |
| SMT201800024T1 (it) | 2018-03-08 |
| BR112016016741A2 (OSRAM) | 2017-08-08 |
| SI3099688T1 (sl) | 2017-12-29 |
| DK3099688T3 (en) | 2018-01-15 |
| EA032650B1 (ru) | 2019-06-28 |
| TWI703144B (zh) | 2020-09-01 |
| PT3099688T (pt) | 2018-01-15 |
| BR112016016741B1 (pt) | 2023-01-17 |
| JP6419836B2 (ja) | 2018-11-07 |
| EP3099688A1 (en) | 2016-12-07 |
| WO2015116882A1 (en) | 2015-08-06 |
| PL3099688T3 (pl) | 2018-03-30 |
| CN106459051A (zh) | 2017-02-22 |
| MX2016009385A (es) | 2016-09-16 |
| CA2937738A1 (en) | 2015-08-06 |
| CN106459051B (zh) | 2018-10-16 |
| AR099228A1 (es) | 2016-07-06 |
| LT3099688T (lt) | 2017-12-27 |
| NO2760821T3 (OSRAM) | 2018-03-10 |
| EA201691561A1 (ru) | 2017-01-30 |
| US20180222907A1 (en) | 2018-08-09 |
| US20170342071A1 (en) | 2017-11-30 |
| CA2937738C (en) | 2023-01-17 |
| EP3099688B1 (en) | 2017-10-18 |
| HUE038060T2 (hu) | 2018-09-28 |
| US20170057961A1 (en) | 2017-03-02 |
| TW201615640A (zh) | 2016-05-01 |
| HRP20172002T1 (hr) | 2018-02-09 |
| UY35972A (es) | 2015-07-31 |
| JP2017504640A (ja) | 2017-02-09 |
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