ES2619314T3 - Expresión génica y dolor - Google Patents

Expresión génica y dolor Download PDF

Info

Publication number
ES2619314T3
ES2619314T3 ES14179247.3T ES14179247T ES2619314T3 ES 2619314 T3 ES2619314 T3 ES 2619314T3 ES 14179247 T ES14179247 T ES 14179247T ES 2619314 T3 ES2619314 T3 ES 2619314T3
Authority
ES
Spain
Prior art keywords
seq
decoy
pain
oligonucleotides
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14179247.3T
Other languages
English (en)
Spanish (es)
Inventor
Julien Mamet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adynxx Inc
Original Assignee
Adynxx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adynxx Inc filed Critical Adynxx Inc
Application granted granted Critical
Publication of ES2619314T3 publication Critical patent/ES2619314T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/13Decoys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
ES14179247.3T 2007-05-11 2008-05-12 Expresión génica y dolor Active ES2619314T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91758307P 2007-05-11 2007-05-11
US917583P 2007-05-11

Publications (1)

Publication Number Publication Date
ES2619314T3 true ES2619314T3 (es) 2017-06-26

Family

ID=40002879

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14179247.3T Active ES2619314T3 (es) 2007-05-11 2008-05-12 Expresión génica y dolor
ES08755344.2T Active ES2542511T3 (es) 2007-05-11 2008-05-12 Expresión génica y dolor

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES08755344.2T Active ES2542511T3 (es) 2007-05-11 2008-05-12 Expresión génica y dolor

Country Status (13)

Country Link
US (5) US7943591B2 (cg-RX-API-DMAC7.html)
EP (3) EP2158316B1 (cg-RX-API-DMAC7.html)
JP (5) JP5646320B2 (cg-RX-API-DMAC7.html)
AU (1) AU2008251320B2 (cg-RX-API-DMAC7.html)
CA (1) CA2723672C (cg-RX-API-DMAC7.html)
DK (1) DK2158316T3 (cg-RX-API-DMAC7.html)
ES (2) ES2619314T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150759T1 (cg-RX-API-DMAC7.html)
HU (1) HUE025701T2 (cg-RX-API-DMAC7.html)
PL (1) PL2158316T3 (cg-RX-API-DMAC7.html)
PT (1) PT2158316E (cg-RX-API-DMAC7.html)
SI (1) SI2158316T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008141308A2 (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20150759T1 (hr) * 2007-05-11 2015-08-14 Adynxx, Inc. Ekspresija gena i bolovi
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
WO2011029092A1 (en) 2009-09-04 2011-03-10 University Of Miami Klf family members regulate intrinsic axon regeneration ability
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
EP2755636A1 (en) 2011-09-16 2014-07-23 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Amphiphilic cationic polymers for the delivery of therapeutic agents
US9139829B2 (en) * 2012-02-28 2015-09-22 Medical Diagnostic Laboratories, Llc SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment
PT2846839T (pt) 2012-05-10 2019-05-29 Adynxx Inc Formulações para a administração de ingredientes ativos
ES2940887T3 (es) 2012-07-13 2023-05-12 Wave Life Sciences Ltd Método de preparación de oligonucleótidos quirales
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
GB201310853D0 (en) * 2013-06-18 2013-07-31 Ucb Pharma Sa Method
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
BR112017002629A2 (pt) 2014-08-15 2018-02-20 Adynxx, Inc. decoys de oligonucleotídeo para o tratamento de dor
JP6993230B2 (ja) * 2015-09-09 2022-01-13 アンジェス株式会社 キメラデコイ
WO2017151644A1 (en) * 2016-02-29 2017-09-08 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression
WO2024044770A1 (en) * 2022-08-26 2024-02-29 Core Biotherapeutics, Inc. Oligonucleotides for the treatment of breast cancer

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150090A (en) 1986-01-09 2000-11-21 Massachusetts Institute Of Technology Nuclear factors associated with transcriptional regulation
US5206152A (en) 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5272056A (en) 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
WO1992018522A1 (en) 1991-04-18 1992-10-29 The Salk Institute For Biological Studies Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
EP0771320A4 (en) 1993-07-29 1998-11-25 Univ California POLYNUCLEOTIDE LURES INHIBITING THE EXPRESSION OF MAJOR II HISTOCOMPATIBILITY COMPLEX, AND APPLICATIONS
PT732929E (pt) 1993-10-29 2008-08-26 Brigham & Womens Hospital Utilização terapêutica de ''engodos'' de elementos cis in vivo
JP3392143B2 (ja) 1994-11-17 2003-03-31 大鵬薬品工業株式会社 二本鎖オリゴヌクレオチド及びこれを有効成分とする制癌剤
AU5369396A (en) 1995-03-23 1996-10-08 Research Foundation Of The State University Of New York, The Rest protein and dna
ES2220929T3 (es) 1995-05-11 2004-12-16 Applied Research Systems Ars Holding N.V. Inhibidor de la actividad il-6.
ES2285712T3 (es) 1995-05-12 2007-11-16 Anges Mg, Inc. Medicamento para la terapia y profilaxis de varias enfermedades relacionadas con nf-kappa b.
GB9515356D0 (en) 1995-07-26 1995-09-20 Medical Res Council Improvements in or relating to delivery of nucleic acid
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
AU737926B2 (en) 1996-05-20 2001-09-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Oligonucleotides which specifically bind retroviral nucleocapsid proteins
US6022863A (en) 1996-05-21 2000-02-08 Yale University Regulation of gene expression
JP4215219B2 (ja) 1997-07-04 2009-01-28 アンジェスMg株式会社 脳保護剤
JP3667047B2 (ja) 1997-09-12 2005-07-06 キヤノン株式会社 人工核酸およびその製造方法、デオキシリボフラノース化合物、リボフラノース化合物およびこれらの製造方法
AU9692198A (en) 1997-10-10 1999-05-03 Kevin J. Donahue Gene delivery compositions and methods
US6060310A (en) 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
JP2002508386A (ja) 1997-12-16 2002-03-19 ザ・ユニバーシティー・オブ・サスカチワン・テクノロジーズ・インコーポレーテッド 導電性金属含有核酸
EA200001124A1 (ru) 1998-06-02 2001-08-27 Глаксо Груп Лимитед Способ генной терапии
US6818626B1 (en) 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6423493B1 (en) 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US6008048A (en) 1998-12-04 1999-12-28 Isis Pharmaceuticals Inc. Antisense inhibition of EGR-1 expression
US7160869B2 (en) 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
AU761136B2 (en) 1998-12-23 2003-05-29 Genentech Inc. Transfectacons comprising calcium phosphate and a nucleic acid
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6333408B1 (en) 1999-03-08 2001-12-25 Kureha Chemical Industry Co., Ltd. Oligonucleotides inhibitors of PAI-1 MRNA
FR2790955B1 (fr) 1999-03-19 2003-01-17 Assist Publ Hopitaux De Paris Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
CA2300328A1 (en) 1999-09-14 2001-03-14 Cardiogene Gentherap. Systeme Ag Modulating transcription of genes in vascular cells
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US6969704B1 (en) 2000-08-25 2005-11-29 The Trustees Of Columbia University In The City Of New York Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
DE10049549A1 (de) 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
WO2002030355A2 (en) 2000-10-11 2002-04-18 Laura Kragie Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase
US20040077573A1 (en) 2000-11-24 2004-04-22 Hiroki Maruyama Method for regulating the activity of an expression product of a gene transferred into living body
US20020137715A1 (en) 2001-01-03 2002-09-26 Alain Mauviel Blocking Sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis
US7060690B2 (en) 2001-01-22 2006-06-13 Genta Incorporated Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
TWI308492B (cg-RX-API-DMAC7.html) 2001-02-20 2009-04-11 Anges Mg Inc
US20070122401A1 (en) 2001-03-06 2007-05-31 Andrews William H Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
US20030166555A1 (en) 2001-04-02 2003-09-04 Alberini Cristina M. Methods and compositions for regulating memory consolidation
EP1298141A1 (en) 2001-09-27 2003-04-02 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Interleukin-4 (IL-4) promoter sequences specifically interacting with IRF-1 and IRF-2
DE10148828B4 (de) 2001-10-04 2005-05-19 Avontec Gmbh Modulation der Expression STAT-1-abhängiger Gene
US6663880B1 (en) 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
MXPA04007124A (es) 2002-02-01 2004-10-29 Omeros Corp Composiciones y metodos para la inhibicion sistemica de la degradacion del cartilago.
CN1240439C (zh) 2002-03-28 2006-02-08 南京凯基生物科技发展有限公司 肿瘤基因开关药物
KR100874798B1 (ko) 2002-04-26 2008-12-19 이인규 전사시 dna 결합부위를 포함하는 원형의 아령형 디코이올리고뉴클레오티드
DE10242319A1 (de) 2002-09-12 2004-03-25 Avontec Gmbh Funkionelle Korrektur der-786C/T-Varianz des humanen eNOS-Gens
DE10257421A1 (de) 2002-12-09 2004-07-08 Grünenthal GmbH Regulatorische Elemente im 5'-Bereich des VR1-Gens
KR20120068035A (ko) 2002-12-09 2012-06-26 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
EP1644532A4 (en) 2003-06-30 2007-11-28 Massachusetts Inst Technology EGR GENES AS OBJECTIVES FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA
US20080233644A1 (en) * 2003-09-12 2008-09-25 Helen Fillmore Chimeric Transcription Factor Decoy Oligonucleotides
JP2005336081A (ja) 2004-05-26 2005-12-08 Anges Mg Inc Nr2b−nmda受容体の再発現抑制剤
US7482158B2 (en) 2004-07-01 2009-01-27 Mathison Brian H Composite polynucleic acid therapeutics
WO2006012625A2 (en) 2004-07-22 2006-02-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Stat3 decoy oligonucleotides and uses therefor
WO2006034433A2 (en) 2004-09-21 2006-03-30 Anesiva, Inc. Delivery of polynucleotides
KR101357016B1 (ko) 2004-09-28 2014-02-03 쿠아크 파마수티칼스 인코퍼레이티드 탈모증, 급성신부전증 및 다른 질환의 치료를 위한올리고리보뉴클레오티드 및 그것의 사용방법
US8067384B2 (en) * 2004-10-22 2011-11-29 Anges Mg, Inc. Chimera (double) decoy
US7585848B2 (en) * 2005-01-11 2009-09-08 Rush University Medical Center Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
WO2006096498A2 (en) * 2005-03-04 2006-09-14 Dana-Farber Cancer Institute, Inc. Regulation of runx1 for treatment of pain
US7680060B2 (en) * 2005-03-08 2010-03-16 Cisco Technology, Inc. Transferring state information in a network
WO2006104913A2 (en) 2005-03-25 2006-10-05 Medtronic, Inc. USE OF ANTI-TNF OR ANTI-ILl RNAI TO SUPPRESS PRO- INFLAMMATORY CYTOKINE ACTIONS LOCALLY TO TREAT PAIN
JP2010505556A (ja) 2006-10-09 2010-02-25 ニューロフルーディクス, インコーポレイテッド 脳脊髄液精製システム
EP2146691A2 (en) 2007-04-17 2010-01-27 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
HRP20150759T1 (hr) 2007-05-11 2015-08-14 Adynxx, Inc. Ekspresija gena i bolovi
PH12013500192B1 (en) 2010-08-20 2018-11-23 Replicor Inc Oligonucleotide chelate complexes
US20140275211A1 (en) 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
AU2012283915B2 (en) 2011-07-20 2016-11-24 Hospira, Inc. Methods of treating pain
PT2846839T (pt) 2012-05-10 2019-05-29 Adynxx Inc Formulações para a administração de ingredientes ativos
TWI635864B (zh) 2012-05-18 2018-09-21 雷普利可公司 寡核苷酸螯合複合物-多肽組合物及方法
BR112017002629A2 (pt) 2014-08-15 2018-02-20 Adynxx, Inc. decoys de oligonucleotídeo para o tratamento de dor
WO2017151644A1 (en) 2016-02-29 2017-09-08 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression

Also Published As

Publication number Publication date
PT2158316E (pt) 2015-07-20
DK2158316T3 (en) 2015-07-20
EP2158316B1 (en) 2015-04-15
SI2158316T1 (sl) 2015-08-31
US8093225B2 (en) 2012-01-10
US10041069B2 (en) 2018-08-07
EP2818550A1 (en) 2014-12-31
EP3199635B1 (en) 2019-02-06
JP5646320B2 (ja) 2014-12-24
US20160222382A1 (en) 2016-08-04
US20080300209A1 (en) 2008-12-04
US9290762B2 (en) 2016-03-22
JP2014198053A (ja) 2014-10-23
JP2016014070A (ja) 2016-01-28
JP2017148074A (ja) 2017-08-31
EP3199635A1 (en) 2017-08-02
US7943591B2 (en) 2011-05-17
JP2010526541A (ja) 2010-08-05
ES2542511T3 (es) 2015-08-06
CA2723672C (en) 2019-09-03
EP2158316A4 (en) 2011-11-09
JP6082796B2 (ja) 2017-02-15
US20140343132A1 (en) 2014-11-20
EP2818550B1 (en) 2016-12-28
CA2723672A1 (en) 2008-11-20
HUE025701T2 (en) 2016-04-28
WO2008141308A3 (en) 2009-03-05
US20110166212A1 (en) 2011-07-07
HRP20150759T1 (hr) 2015-08-14
EP2158316A2 (en) 2010-03-03
WO2008141308A2 (en) 2008-11-20
JP5890869B2 (ja) 2016-03-22
AU2008251320A1 (en) 2008-11-20
AU2008251320B2 (en) 2013-12-19
JP6306075B2 (ja) 2018-04-04
JP2016117775A (ja) 2016-06-30
HK1205530A1 (en) 2015-12-18
PL2158316T3 (pl) 2015-10-30
US8741864B2 (en) 2014-06-03
US20120232131A1 (en) 2012-09-13

Similar Documents

Publication Publication Date Title
ES2619314T3 (es) Expresión génica y dolor
DE69221730T2 (de) Sequenzspezifische bindende Polymere für Duplex Nucleinsäuren
JP2670434B2 (ja) ポリヌクレオチド測定試薬と方法
ES2199236T3 (es) Ensayos tipo sandwich de acido nucleico en fase de solucion habiendo reducido el ruido de fondo.
ES2256852T3 (es) Utilizacion de arnm localizados en las neuritas para el diagnostico y la terapeutica medicos.
Portugal et al. Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA
Sørensen et al. Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers
Leaman et al. Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense
JP5606318B2 (ja) トランスフェクション剤
AU2014201462B2 (en) Gene expression and pain
Kwok et al. The quinobenzoxazines: relationship between DNA binding and biological activity
AU2016266076B2 (en) Gene expression and pain
Gustafson The synthesis and biochemical evaluation of a series of anthramycin-based DNA processing molecules
PT2236612E (pt) Biblioteca de oligonucleótidos que codifica para péptidos aleatórios
DE102005052275A1 (de) Ethylaminspezifische Aptamere, deren Verwendung und ein Kit umfassend diese Aptamere