CA2723672C - Gene expression and pain - Google Patents

Gene expression and pain Download PDF

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Publication number
CA2723672C
CA2723672C CA2723672A CA2723672A CA2723672C CA 2723672 C CA2723672 C CA 2723672C CA 2723672 A CA2723672 A CA 2723672A CA 2723672 A CA2723672 A CA 2723672A CA 2723672 C CA2723672 C CA 2723672C
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Canada
Prior art keywords
seq
nucleotide
sequence
oligonucleotide
pain
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Active
Application number
CA2723672A
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English (en)
French (fr)
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CA2723672A1 (en
Inventor
Julien Mamet
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Vyripharm Enterprises Inc
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Adynxx Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/13Decoys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CA2723672A 2007-05-11 2008-05-12 Gene expression and pain Active CA2723672C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91758307P 2007-05-11 2007-05-11
US60/917,583 2007-05-11
PCT/US2008/063471 WO2008141308A2 (en) 2007-05-11 2008-05-12 Gene expression and pain

Publications (2)

Publication Number Publication Date
CA2723672A1 CA2723672A1 (en) 2008-11-20
CA2723672C true CA2723672C (en) 2019-09-03

Family

ID=40002879

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2723672A Active CA2723672C (en) 2007-05-11 2008-05-12 Gene expression and pain

Country Status (13)

Country Link
US (5) US7943591B2 (cg-RX-API-DMAC7.html)
EP (3) EP2818550B1 (cg-RX-API-DMAC7.html)
JP (5) JP5646320B2 (cg-RX-API-DMAC7.html)
AU (1) AU2008251320B2 (cg-RX-API-DMAC7.html)
CA (1) CA2723672C (cg-RX-API-DMAC7.html)
DK (1) DK2158316T3 (cg-RX-API-DMAC7.html)
ES (2) ES2542511T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150759T1 (cg-RX-API-DMAC7.html)
HU (1) HUE025701T2 (cg-RX-API-DMAC7.html)
PL (1) PL2158316T3 (cg-RX-API-DMAC7.html)
PT (1) PT2158316E (cg-RX-API-DMAC7.html)
SI (1) SI2158316T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008141308A2 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
SI2158316T1 (sl) 2015-08-31
CA2723672A1 (en) 2008-11-20
HK1205530A1 (en) 2015-12-18
EP2818550B1 (en) 2016-12-28
US8741864B2 (en) 2014-06-03
US20080300209A1 (en) 2008-12-04
JP2014198053A (ja) 2014-10-23
AU2008251320A1 (en) 2008-11-20
PT2158316E (pt) 2015-07-20
US9290762B2 (en) 2016-03-22
ES2619314T3 (es) 2017-06-26
PL2158316T3 (pl) 2015-10-30
JP2016117775A (ja) 2016-06-30
ES2542511T3 (es) 2015-08-06
JP2017148074A (ja) 2017-08-31
EP3199635B1 (en) 2019-02-06
US8093225B2 (en) 2012-01-10
US10041069B2 (en) 2018-08-07
EP3199635A1 (en) 2017-08-02
HRP20150759T1 (hr) 2015-08-14
JP5890869B2 (ja) 2016-03-22
EP2158316A4 (en) 2011-11-09
DK2158316T3 (en) 2015-07-20
AU2008251320B2 (en) 2013-12-19
EP2158316B1 (en) 2015-04-15
JP6306075B2 (ja) 2018-04-04
US20110166212A1 (en) 2011-07-07
JP5646320B2 (ja) 2014-12-24
EP2158316A2 (en) 2010-03-03
HUE025701T2 (en) 2016-04-28
JP6082796B2 (ja) 2017-02-15
US7943591B2 (en) 2011-05-17
WO2008141308A3 (en) 2009-03-05
WO2008141308A2 (en) 2008-11-20
EP2818550A1 (en) 2014-12-31
US20120232131A1 (en) 2012-09-13
US20140343132A1 (en) 2014-11-20
US20160222382A1 (en) 2016-08-04
JP2010526541A (ja) 2010-08-05
JP2016014070A (ja) 2016-01-28

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