PL2158316T3 - Ekspresja genowa oraz ból - Google Patents

Ekspresja genowa oraz ból

Info

Publication number
PL2158316T3
PL2158316T3 PL08755344T PL08755344T PL2158316T3 PL 2158316 T3 PL2158316 T3 PL 2158316T3 PL 08755344 T PL08755344 T PL 08755344T PL 08755344 T PL08755344 T PL 08755344T PL 2158316 T3 PL2158316 T3 PL 2158316T3
Authority
PL
Poland
Prior art keywords
pain
gene expression
gene
expression
Prior art date
Application number
PL08755344T
Other languages
English (en)
Inventor
Julien Mamet
Original Assignee
Adynxx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adynxx Inc filed Critical Adynxx Inc
Publication of PL2158316T3 publication Critical patent/PL2158316T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
PL08755344T 2007-05-11 2008-05-12 Ekspresja genowa oraz ból PL2158316T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91758307P 2007-05-11 2007-05-11
EP08755344.2A EP2158316B1 (en) 2007-05-11 2008-05-12 Gene expression and pain
PCT/US2008/063471 WO2008141308A2 (en) 2007-05-11 2008-05-12 Gene expression and pain

Publications (1)

Publication Number Publication Date
PL2158316T3 true PL2158316T3 (pl) 2015-10-30

Family

ID=40002879

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08755344T PL2158316T3 (pl) 2007-05-11 2008-05-12 Ekspresja genowa oraz ból

Country Status (14)

Country Link
US (5) US7943591B2 (pl)
EP (3) EP3199635B1 (pl)
JP (5) JP5646320B2 (pl)
AU (1) AU2008251320B2 (pl)
CA (1) CA2723672C (pl)
DK (1) DK2158316T3 (pl)
ES (2) ES2619314T3 (pl)
HK (1) HK1205530A1 (pl)
HR (1) HRP20150759T1 (pl)
HU (1) HUE025701T2 (pl)
PL (1) PL2158316T3 (pl)
PT (1) PT2158316E (pl)
SI (1) SI2158316T1 (pl)
WO (1) WO2008141308A2 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3199635B1 (en) * 2007-05-11 2019-02-06 Adynxx, Inc. Gene expression and pain
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US8609617B2 (en) 2009-09-04 2013-12-17 University Of Miami KLF family members regulate intrinsic axon regeneration ability
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
EP2755636A1 (en) 2011-09-16 2014-07-23 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Amphiphilic cationic polymers for the delivery of therapeutic agents
US9139829B2 (en) * 2012-02-28 2015-09-22 Medical Diagnostic Laboratories, Llc SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment
EP2846839B1 (en) 2012-05-10 2019-02-20 Adynxx, Inc. Formulations for the delivery of active ingredients
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
GB201310853D0 (en) * 2013-06-18 2013-07-31 Ucb Pharma Sa Method
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
ES2912176T3 (es) * 2015-09-09 2022-05-24 Anges Inc Señuelo quimérico
US20200017853A1 (en) * 2016-02-29 2020-01-16 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression
WO2024044770A1 (en) * 2022-08-26 2024-02-29 Core Biotherapeutics, Inc. Oligonucleotides for the treatment of breast cancer

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410516B1 (en) * 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US5206152A (en) * 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5272056A (en) 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
US5683985A (en) * 1991-04-18 1997-11-04 The Salk Institute For Biological Studies Oligonucleotide decoys and methods relating thereto
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
WO1995004064A1 (en) * 1993-07-29 1995-02-09 The Regents Of The University Of California Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof
EP1340505A3 (en) * 1993-10-29 2004-07-14 The Brigham And Women's Hospital, Inc. Therapeutic use of cis-element decoys in vivo
US6034234A (en) 1994-11-17 2000-03-07 Taiho Pharmaceutical Co., Ltd. Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient
WO1996029433A1 (en) 1995-03-23 1996-09-26 Research Foundation Of State University Of New York Rest protein and dna
WO1996035782A1 (en) * 1995-05-11 1996-11-14 Applied Research Systems Il-6 activity inhibitor
EP0824918B1 (en) * 1995-05-12 2007-03-28 AnGes MG, Inc. REMEDY AND PREVENTIVE FOR DISEASES CAUSED BY NF-kappaB
GB9515356D0 (en) 1995-07-26 1995-09-20 Medical Res Council Improvements in or relating to delivery of nucleic acid
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
WO1997044064A2 (en) * 1996-05-20 1997-11-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Oligonucleotides which specifically bind retroviral nucleocapsid proteins
US6022863A (en) * 1996-05-21 2000-02-08 Yale University Regulation of gene expression
US6890909B1 (en) * 1997-07-04 2005-05-10 Fujisawa Pharmaceutical Co., Ltd. Brain-protective agent
JP3667047B2 (ja) 1997-09-12 2005-07-06 キヤノン株式会社 人工核酸およびその製造方法、デオキシリボフラノース化合物、リボフラノース化合物およびこれらの製造方法
US6376471B1 (en) 1997-10-10 2002-04-23 Johns Hopkins University Gene delivery compositions and methods
US6060310A (en) * 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
US6432641B1 (en) 1997-12-16 2002-08-13 University Of Saskatchewan Technologies Inc. Conductive metal-containing nucleic acids
DE69910202T2 (de) 1998-06-02 2004-06-17 Glaxo Group Ltd., Greenford EGR-1 zur Herstellung eines Medikamentes zur Behandlung von Wunden
US6818626B1 (en) 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6423493B1 (en) * 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US6008048A (en) * 1998-12-04 1999-12-28 Isis Pharmaceuticals Inc. Antisense inhibition of EGR-1 expression
US7160869B2 (en) 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
DE69935252D1 (de) 1998-12-23 2007-04-05 Genentech Inc Transfectaconen, die kalciumphosphat und eine nucleinsäure enthalten
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6333408B1 (en) * 1999-03-08 2001-12-25 Kureha Chemical Industry Co., Ltd. Oligonucleotides inhibitors of PAI-1 MRNA
FR2790955B1 (fr) * 1999-03-19 2003-01-17 Assist Publ Hopitaux De Paris Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
CA2300328A1 (en) * 1999-09-14 2001-03-14 Cardiogene Gentherap. Systeme Ag Modulating transcription of genes in vascular cells
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US6969704B1 (en) * 2000-08-25 2005-11-29 The Trustees Of Columbia University In The City Of New York Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
DE10049549A1 (de) 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
US20040192598A1 (en) 2000-10-11 2004-09-30 Laura Kragie Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase
JPWO2002041922A1 (ja) 2000-11-24 2004-03-25 丸山　弘樹 生体に導入された遺伝子の発現産物の活性を制御する方法
US20020137715A1 (en) 2001-01-03 2002-09-26 Alain Mauviel Blocking Sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis
AU2002241952A1 (en) * 2001-01-22 2002-07-30 Genta Incorporated Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers
EP1690544B1 (en) 2001-02-20 2017-09-13 AnGes MG, Inc. Pharmaceutical composition containing decoy and method of using the same
AU2002254132A1 (en) 2001-03-06 2002-09-19 Sierra Sciences, Inc. Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
US20030166555A1 (en) * 2001-04-02 2003-09-04 Alberini Cristina M. Methods and compositions for regulating memory consolidation
EP1298141A1 (en) 2001-09-27 2003-04-02 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Interleukin-4 (IL-4) promoter sequences specifically interacting with IRF-1 and IRF-2
DE10148828B4 (de) * 2001-10-04 2005-05-19 Avontec Gmbh Modulation der Expression STAT-1-abhängiger Gene
US6663880B1 (en) 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
CA2474645C (en) 2002-02-01 2011-08-09 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
CN1240439C (zh) 2002-03-28 2006-02-08 南京凯基生物科技发展有限公司 肿瘤基因开关药物
JP4255123B2 (ja) 2002-04-26 2009-04-15 アンジェスＭｇ株式会社 転写ｄｎａ結合部位を含む環状ダンベルデコイオリゴデオキシヌクレオチド（ｃｄｏｄｎ）
DE10242319A1 (de) * 2002-09-12 2004-03-25 Avontec Gmbh Funkionelle Korrektur der-786C/T-Varianz des humanen eNOS-Gens
DE10257421A1 (de) * 2002-12-09 2004-07-08 Grünenthal GmbH Regulatorische Elemente im 5'-Bereich des VR1-Gens
KR20180098702A (ko) 2002-12-09 2018-09-04 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
AU2004255223A1 (en) 2003-06-30 2005-01-20 Massachusetts Institute Of Technology EGR genes as targets for the diagnosis and treatment of schizophrenia
WO2005027830A2 (en) * 2003-09-12 2005-03-31 Virginia Commonwealth University Chimeric transcription factor decoy oligonucleotides
JP2005336081A (ja) * 2004-05-26 2005-12-08 Anges Mg Inc Ｎｒ２ｂ−ｎｍｄａ受容体の再発現抑制剤
US7482158B2 (en) * 2004-07-01 2009-01-27 Mathison Brian H Composite polynucleic acid therapeutics
US20060293264A1 (en) * 2004-07-22 2006-12-28 Grandis Jennifer R STAT3 decoy oligonucleotides and uses therefor
EP1799271A4 (en) * 2004-09-21 2010-05-05 Anesiva Inc ADMINISTRATION OF POLYNUCLEOTIDES
LT1799269T (lt) 2004-09-28 2016-10-25 Quark Pharmaceuticals, Inc. Oligoribonukleotidai ir jų naudojimo būdai alopecijos, ūminio inkstų nepakankamumo ir kitų ligų gydymui
JP4921975B2 (ja) 2004-10-22 2012-04-25 アンジェスＭｇ株式会社 キメラ（ダブル）デコイ
US7585848B2 (en) * 2005-01-11 2009-09-08 Rush University Medical Center Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
US8268572B2 (en) * 2005-03-04 2012-09-18 Dana-Farber Cancer Institute, Inc. Methods to identify inhibitors of Runx1-mediated expression of nociceptive receptors and ion channels
US7680060B2 (en) * 2005-03-08 2010-03-16 Cisco Technology, Inc. Transferring state information in a network
WO2006104913A2 (en) * 2005-03-25 2006-10-05 Medtronic, Inc. USE OF ANTI-TNF OR ANTI-ILl RNAI TO SUPPRESS PRO- INFLAMMATORY CYTOKINE ACTIONS LOCALLY TO TREAT PAIN
ES2845146T3 (es) 2006-10-09 2021-07-26 Neurofluidics Inc Sistema de purificación de líquido cefalorraquídeo
AU2008242842B2 (en) 2007-04-17 2014-06-05 Baxter Healthcare Sa Nucleic acid microparticles for pulmonary delivery
EP3199635B1 (en) * 2007-05-11 2019-02-06 Adynxx, Inc. Gene expression and pain
EP2605794B1 (en) 2010-08-20 2016-07-20 Replicor Inc. Oligonucleotide chelate complexes
CA2839896A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
BR112014001335A2 (pt) 2011-07-20 2017-02-21 Hospira Inc método para tratar dor pós-operatória em um mamífero e método para tratar dor em um mamífero
EP2846839B1 (en) 2012-05-10 2019-02-20 Adynxx, Inc. Formulations for the delivery of active ingredients
SI2849798T1 (sl) 2012-05-18 2021-08-31 Replicor Inc. Oligonukleotidni kelatni kompleksni polipeptidni sestavki in postopki
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
US20200017853A1 (en) 2016-02-29 2020-01-16 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression

Also Published As

Publication number Publication date
US8741864B2 (en) 2014-06-03
WO2008141308A2 (en) 2008-11-20
JP2016117775A (ja) 2016-06-30
EP2158316A4 (en) 2011-11-09
US7943591B2 (en) 2011-05-17
AU2008251320A1 (en) 2008-11-20
US9290762B2 (en) 2016-03-22
US20110166212A1 (en) 2011-07-07
JP6082796B2 (ja) 2017-02-15
ES2619314T3 (es) 2017-06-26
ES2542511T3 (es) 2015-08-06
US20120232131A1 (en) 2012-09-13
US20080300209A1 (en) 2008-12-04
US20160222382A1 (en) 2016-08-04
HUE025701T2 (en) 2016-04-28
JP5890869B2 (ja) 2016-03-22
JP2014198053A (ja) 2014-10-23
AU2008251320B2 (en) 2013-12-19
CA2723672A1 (en) 2008-11-20
JP6306075B2 (ja) 2018-04-04
EP2158316A2 (en) 2010-03-03
EP2158316B1 (en) 2015-04-15
CA2723672C (en) 2019-09-03
JP5646320B2 (ja) 2014-12-24
US8093225B2 (en) 2012-01-10
DK2158316T3 (en) 2015-07-20
EP3199635A1 (en) 2017-08-02
EP3199635B1 (en) 2019-02-06
US20140343132A1 (en) 2014-11-20
HK1205530A1 (en) 2015-12-18
HRP20150759T1 (hr) 2015-08-14
JP2017148074A (ja) 2017-08-31
EP2818550A1 (en) 2014-12-31
PT2158316E (pt) 2015-07-20
SI2158316T1 (sl) 2015-08-31
US10041069B2 (en) 2018-08-07
EP2818550B1 (en) 2016-12-28
WO2008141308A3 (en) 2009-03-05
JP2010526541A (ja) 2010-08-05
JP2016014070A (ja) 2016-01-28

Similar Documents

Publication Publication Date Title
HK1205530A1 (en) Gene expression and pain
IL205571A0 (en) 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin
EP2069496A4 (en) SELEX AND PHOTOSELEX ENHANCED
ZA201200161B (en) Aximi-205 pesticidal gene and methods for its use
EP2185692A4 (en) HCO32 AND HCO27 AND RELATED EXAMPLES
PL2150617T3 (pl) Wzmocniona ekspresja i regiony stabilności
EP2157919A4 (en) DEVICES AND METHODS FOR ENDOSCOPIC DELIVERY
HK1147254A1 (en) 5-anilinoimidazopyridines and methods of use 5-
EP2240231A4 (en) MULTIFUNCTION CATHETER AND ITS USE
EP2518147A4 (en) DIACYLGLYCEROLACYLTRANSFERASEGEN AND ITS USE
IL206125A0 (en) Azaindolizines and methods of use
GB0603167D0 (en) Skin application
EP2247601A4 (en) THIAZOPYRIMIDINONE AND APPLICATIONS THEREOF
EP2213675A4 (en) PYRIDOOXAZEPINE DERIVATIVE AND USE THEREOF
PL2154144T3 (pl) Oligonukleotydy i ich zastosowanie
EP2133326A4 (en) NEW PSEUDOGLYCOLIPID AND ITS USE
ZA201000357B (en) 2-Azetidinemethaneamines and 2-pyrrolidinemethaneamines as Taar-Ligands
GB0813359D0 (en) Halfin and/or platerfin
GB0707069D0 (en) Methods and uses
EP2041311A4 (en) VARIANTS OF THE DPYD GENE AND THEIR USE
EP2427766A4 (en) HUMAN GENE FG01 AND ITS APPLICATIONS
GB0812734D0 (en) MEdical compsoitions and devices
EP2168951A4 (en) AZOLYLMETHYLIDENHYDRAZINE DERIVATIVE AND ITS USE
GB0818663D0 (en) Gene regulation and its use in therapy
GB0720675D0 (en) Oligonucleotides and uses thereof