EA200001124A1 - Способ генной терапии - Google Patents
Способ генной терапииInfo
- Publication number
- EA200001124A1 EA200001124A1 EA200001124A EA200001124A EA200001124A1 EA 200001124 A1 EA200001124 A1 EA 200001124A1 EA 200001124 A EA200001124 A EA 200001124A EA 200001124 A EA200001124 A EA 200001124A EA 200001124 A1 EA200001124 A1 EA 200001124A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- egr
- nucleic acid
- sequence
- acid molecules
- transcription factor
- Prior art date
Links
- 238000001415 gene therapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 206010052428 Wound Diseases 0.000 abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 108010051542 Early Growth Response Protein 1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 101100444898 Mus musculus Egr1 gene Proteins 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Данное изобретение относится к применению полипептида транскрипционного фактора раннего ростового ответа 1 (Egr-1) или его биологически активного фрагмента и молекулам нуклеиновых кислот, кодирующих такие полипептиды, в изготовлении лекарства для лечения ран у млекопитающего, включая человека. Кроме того, оно относится к последовательности, которая, как полагают, содержит важные области, вовлеченные в транскрипцию транскрипционного фактора Egr-1 у людей и в ее регуляцию. Эту последовательность можно использовать для разработки подходящих молекул нуклеиновых кислот и векторов, которые можно применять в лечении ран, а также в другом лечении.Отчет о международном поиске был опубликован 2000.08.03.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9811836.7A GB9811836D0 (en) | 1998-06-02 | 1998-06-02 | Gene therapy method |
GBGB9815035.2A GB9815035D0 (en) | 1998-07-11 | 1998-07-11 | Gene therapy method |
GBGB9819846.8A GB9819846D0 (en) | 1998-09-12 | 1998-09-12 | Gene therapy method |
GBGB9828578.6A GB9828578D0 (en) | 1998-12-23 | 1998-12-23 | Regulation |
PCT/GB1999/001722 WO1999062561A2 (en) | 1998-06-02 | 1999-06-02 | Gene therapy method |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200001124A1 true EA200001124A1 (ru) | 2001-08-27 |
Family
ID=27451790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200001124A EA200001124A1 (ru) | 1998-06-02 | 1999-06-02 | Способ генной терапии |
Country Status (29)
Country | Link |
---|---|
US (1) | US6689758B1 (ru) |
EP (2) | EP1083934B1 (ru) |
JP (1) | JP2002516676A (ru) |
KR (1) | KR20010043968A (ru) |
CN (1) | CN1311822A (ru) |
AP (1) | AP2000001999A0 (ru) |
AT (1) | ATE246518T1 (ru) |
AU (1) | AU770497B2 (ru) |
BR (1) | BR9910877A (ru) |
CA (1) | CA2334171A1 (ru) |
DE (1) | DE69910202T2 (ru) |
DK (1) | DK1083934T3 (ru) |
EA (1) | EA200001124A1 (ru) |
EE (1) | EE200000790A (ru) |
ES (1) | ES2205830T3 (ru) |
HK (1) | HK1034465A1 (ru) |
HR (1) | HRP20000832A2 (ru) |
HU (1) | HUP0103252A3 (ru) |
ID (1) | ID27483A (ru) |
IL (1) | IL139936A0 (ru) |
IS (1) | IS5742A (ru) |
NO (1) | NO20006047L (ru) |
NZ (1) | NZ508505A (ru) |
PL (1) | PL345207A1 (ru) |
PT (1) | PT1083934E (ru) |
SK (1) | SK18322000A3 (ru) |
TR (2) | TR200102985T2 (ru) |
WO (1) | WO1999062561A2 (ru) |
YU (1) | YU75600A (ru) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9928430D0 (en) * | 1999-12-01 | 2000-01-26 | Glaxo Group Ltd | Screening |
ATE397753T1 (de) * | 2002-01-10 | 2008-06-15 | Takeda Pharmaceutical | Screening-verfahren für eine prophylaktische und therapeutische substanz für eine nierenerkrankung |
AU2003302337A1 (en) * | 2002-12-31 | 2004-07-29 | The Johns Hopkins University | Wound healing method and kits |
EP1671655A4 (en) * | 2003-08-29 | 2009-08-12 | Anges Mg Inc | GENE THERAPY FOR SKIN DISEASE USING NEEDLE-FREE SYRINGE |
DE10342071B4 (de) * | 2003-09-10 | 2006-01-19 | Fleischmann, Wilhelm, Dr.med. | Vorrichtung und Verfahren zur Applikation von Wïrkstoffen an eine Wundoberfläche |
KR100647490B1 (ko) | 2004-10-04 | 2006-11-23 | 사회복지법인 삼성생명공익재단 | 저산소 조건 및 다른 스트레스에 특이적으로 반응할 수있는 키메라 인핸서 요소를 포함하는 벡터, 상기 벡터를포함하는 약제학적 조성물 및 상기 조성물을 이용하는 방법 |
EP2818550B1 (en) | 2007-05-11 | 2016-12-28 | Adynxx, Inc. | Gene expression and pain |
FR2920158B1 (fr) * | 2007-08-24 | 2010-03-12 | Centre Nat Rech Scient | Production de plasmides et expression de proteines recombinantes dans des cellules cultivees sans antibiotiques |
FR2924128A1 (fr) * | 2007-11-26 | 2009-05-29 | Galderma Res & Dev | Modulateurs de egr1 dans le traitement de l'alopecie |
CN102471769A (zh) | 2009-07-17 | 2012-05-23 | 亚伦·T.·塔波尔 | 用于具有美容功能的细胞的遗传修饰以提高美容外观的方法和组合物 |
CN102552938A (zh) * | 2012-03-22 | 2012-07-11 | 南京大学 | Egr-1拮抗剂在制备治疗Ⅱ型糖尿病的药物中的用途 |
BR112014027653A2 (pt) | 2012-05-10 | 2017-08-08 | Adynxx Inc | formulações para a liberação dos ingredientes ativos |
WO2016025829A1 (en) | 2014-08-15 | 2016-02-18 | Adynxx, Inc. | Oligonucleotide decoys for the treatment of pain |
KR101721228B1 (ko) * | 2015-04-03 | 2017-03-30 | 사회복지법인 삼성생명공익재단 | 지방유래 줄기세포의 배양액을 유효성분으로 포함하는 발모촉진용 조성물 |
CN104857529A (zh) * | 2015-05-20 | 2015-08-26 | 山西大学 | Egr-1基因在制备抗膀胱癌药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763209A (en) | 1988-09-26 | 1998-06-09 | Arch Development Corporation | Methods and materials relating to the functional domains of DNA binding proteins |
US5206152A (en) | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
AUPN855496A0 (en) | 1996-03-07 | 1996-04-04 | Unisearch Limited | Prevention of proliferation of vascular cells |
-
1999
- 1999-06-02 IL IL13993699A patent/IL139936A0/xx unknown
- 1999-06-02 TR TR2001/02985T patent/TR200102985T2/xx unknown
- 1999-06-02 EE EEP200000790A patent/EE200000790A/xx unknown
- 1999-06-02 PL PL99345207A patent/PL345207A1/xx not_active Application Discontinuation
- 1999-06-02 BR BR9910877-1A patent/BR9910877A/pt not_active IP Right Cessation
- 1999-06-02 TR TR2001/00348T patent/TR200100348T2/xx unknown
- 1999-06-02 EA EA200001124A patent/EA200001124A1/ru unknown
- 1999-06-02 SK SK1832-2000A patent/SK18322000A3/sk unknown
- 1999-06-02 YU YU75600A patent/YU75600A/sh unknown
- 1999-06-02 ES ES99925174T patent/ES2205830T3/es not_active Expired - Lifetime
- 1999-06-02 WO PCT/GB1999/001722 patent/WO1999062561A2/en not_active Application Discontinuation
- 1999-06-02 DE DE69910202T patent/DE69910202T2/de not_active Expired - Fee Related
- 1999-06-02 EP EP99925174A patent/EP1083934B1/en not_active Expired - Lifetime
- 1999-06-02 US US09/701,749 patent/US6689758B1/en not_active Expired - Fee Related
- 1999-06-02 AP APAP/P/2000/001999A patent/AP2000001999A0/en unknown
- 1999-06-02 EP EP02020179A patent/EP1281763A3/en not_active Withdrawn
- 1999-06-02 ID IDW20002711A patent/ID27483A/id unknown
- 1999-06-02 PT PT99925174T patent/PT1083934E/pt unknown
- 1999-06-02 CN CN99809287A patent/CN1311822A/zh active Pending
- 1999-06-02 AU AU41560/99A patent/AU770497B2/en not_active Expired - Fee Related
- 1999-06-02 KR KR1020007013584A patent/KR20010043968A/ko not_active Application Discontinuation
- 1999-06-02 AT AT99925174T patent/ATE246518T1/de not_active IP Right Cessation
- 1999-06-02 NZ NZ508505A patent/NZ508505A/xx unknown
- 1999-06-02 DK DK99925174T patent/DK1083934T3/da active
- 1999-06-02 CA CA002334171A patent/CA2334171A1/en not_active Abandoned
- 1999-06-02 HU HU0103252A patent/HUP0103252A3/hu unknown
- 1999-06-02 JP JP2000551815A patent/JP2002516676A/ja active Pending
-
2000
- 2000-11-28 IS IS5742A patent/IS5742A/is unknown
- 2000-11-29 NO NO20006047A patent/NO20006047L/no not_active Application Discontinuation
- 2000-12-01 HR HR20000832A patent/HRP20000832A2/hr not_active Application Discontinuation
-
2001
- 2001-07-24 HK HK01105197A patent/HK1034465A1/xx not_active IP Right Cessation
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