ES2529190T3 - 2-(2,6-dioxopiperidin-3-il)-ftalimidas sustituidas por amino para reducir los niveles de TNF-alfa - Google Patents
2-(2,6-dioxopiperidin-3-il)-ftalimidas sustituidas por amino para reducir los niveles de TNF-alfa Download PDFInfo
- Publication number
- ES2529190T3 ES2529190T3 ES10183268.1T ES10183268T ES2529190T3 ES 2529190 T3 ES2529190 T3 ES 2529190T3 ES 10183268 T ES10183268 T ES 10183268T ES 2529190 T3 ES2529190 T3 ES 2529190T3
- Authority
- ES
- Spain
- Prior art keywords
- dioxopiperidin
- mixture
- oxo
- water
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08690258 US5635517B1 (en) | 1996-07-24 | 1996-07-24 | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US690258 | 1996-07-24 | ||
| US701494 | 1996-08-22 | ||
| US08/701,494 US5798368A (en) | 1996-08-22 | 1996-08-22 | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US4827897P | 1997-05-30 | 1997-05-30 | |
| US48278P | 1997-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2529190T3 true ES2529190T3 (es) | 2015-02-17 |
Family
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97936295.1T Active ES2187805T7 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-Dioxopiperidin-3-il)-ftalimidas y 1-oxoisoindolinas y método para reducir los niveles de TNF-alfa |
| ES02012942T Expired - Lifetime ES2339425T3 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-dioxopiperidin-3-il)-ftalimidas y -1-oxoisoindolinas sustituidas y procedimiento para reducir los niveles de tnf-alfa. |
| ES10152833T Expired - Lifetime ES2372577T3 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-dioxopiperidin-3-il)-ftalimidas sustituidas por amino para reducir los niveles de tnf-alfa. |
| ES10183268.1T Expired - Lifetime ES2529190T3 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-dioxopiperidin-3-il)-ftalimidas sustituidas por amino para reducir los niveles de TNF-alfa |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97936295.1T Active ES2187805T7 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-Dioxopiperidin-3-il)-ftalimidas y 1-oxoisoindolinas y método para reducir los niveles de TNF-alfa |
| ES02012942T Expired - Lifetime ES2339425T3 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-dioxopiperidin-3-il)-ftalimidas y -1-oxoisoindolinas sustituidas y procedimiento para reducir los niveles de tnf-alfa. |
| ES10152833T Expired - Lifetime ES2372577T3 (es) | 1996-07-24 | 1997-07-24 | 2-(2,6-dioxopiperidin-3-il)-ftalimidas sustituidas por amino para reducir los niveles de tnf-alfa. |
Country Status (21)
| Country | Link |
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| EP (4) | EP2305663B1 (enExample) |
| JP (1) | JP4065567B2 (enExample) |
| KR (2) | KR20050032629A (enExample) |
| CN (1) | CN1117089C (enExample) |
| AT (4) | ATE500240T1 (enExample) |
| CA (3) | CA2261762C (enExample) |
| CZ (3) | CZ302378B6 (enExample) |
| DE (4) | DE69717831T3 (enExample) |
| DK (2) | DK0925294T6 (enExample) |
| ES (4) | ES2187805T7 (enExample) |
| FI (1) | FI120687B (enExample) |
| FR (1) | FR07C0056I2 (enExample) |
| HU (1) | HUS1300056I1 (enExample) |
| LU (1) | LU91359I2 (enExample) |
| NL (1) | NL300291I2 (enExample) |
| NZ (1) | NZ333903A (enExample) |
| PL (2) | PL191566B1 (enExample) |
| PT (4) | PT1285916E (enExample) |
| SK (1) | SK9199A3 (enExample) |
| UA (1) | UA60308C2 (enExample) |
| WO (1) | WO1998003502A1 (enExample) |
Families Citing this family (207)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
| US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
| CZ302378B6 (cs) * | 1996-07-24 | 2011-04-20 | Celgene Corporation | Optický izomer (S)-1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindolin a farmaceutická kompozice s jeho obsahem |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| DE19703763C1 (de) * | 1997-02-01 | 1998-10-01 | Gruenenthal Gmbh | Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione |
| ATE327228T1 (de) * | 1997-11-18 | 2006-06-15 | Celgene Corp | Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3- yl)-isoindoline und ihre verwendung zum reduzieren des tnf-alpha spiegels |
| US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| TR200101504T2 (tr) * | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı. |
| CA2361806C (en) | 1999-03-18 | 2012-03-13 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| DE19917195B4 (de) * | 1999-04-16 | 2006-09-28 | Immatics Biotechnologies Gmbh | Peptid zur Auslösung einer Immunreaktion gegen Tumorzellen, diese enthaltende pharmzeutische Zusammensetzungen, dessen Verwendungen, dafür codierende Nukleinsäure und diese Nukleinsäure enthaltender Expressionsvektor |
| US7629360B2 (en) | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US7182953B2 (en) * | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| CA2430669C (en) * | 2000-11-30 | 2011-06-14 | The Children's Medical Center Corporation | Synthesis of 3-amino-thalidomide and its enantiomers |
| PL362979A1 (en) * | 2000-12-11 | 2004-11-02 | Takeda Chemical Industries, Ltd. | Medicinal compositions improved in solublity in water |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
| CA2457319C (en) * | 2001-08-06 | 2011-07-05 | The Children's Medical Center Corporation | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| SI1505973T1 (sl) | 2002-05-17 | 2010-06-30 | Celgene Corp | Kombinacija za zdravljenje multiplega mieloma |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US8404717B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| EP1900369A1 (en) | 2002-10-15 | 2008-03-19 | Celgene Corporation | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| FR2845994B1 (fr) * | 2002-10-18 | 2006-05-19 | Servier Lab | Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| NZ540028A (en) * | 2002-10-24 | 2009-07-31 | Celgene Corp | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
| AU2003287381B2 (en) * | 2002-10-31 | 2008-03-06 | Celgene Corporation | Composition for the treatment of macular degenration |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| CH696542A5 (de) * | 2003-07-09 | 2007-07-31 | Siegfried Ltd | Verfahren zur Herstellung von substituierten 2,6-Dioxopiperidin-3-yl-Verbindungen. |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US8952895B2 (en) | 2011-06-03 | 2015-02-10 | Apple Inc. | Motion-based device operations |
| CA2538864C (en) | 2003-09-17 | 2013-05-07 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
| US7612096B2 (en) | 2003-10-23 | 2009-11-03 | Celgene Corporation | Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline |
| US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| CN1956718A (zh) | 2004-03-22 | 2007-05-02 | 细胞基因公司 | 用于治疗和控制皮肤疾病和病症的含免疫调节化合物的组合物和使用方法 |
| US20090163548A1 (en) * | 2004-05-05 | 2009-06-25 | Zeldis Jerome B | Method of using and comopositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases |
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