ES2527418T3 - Derivados de piridinona novedosos y su uso como moduladores alostéricos positivos de receptores mGluR2 - Google Patents

Derivados de piridinona novedosos y su uso como moduladores alostéricos positivos de receptores mGluR2 Download PDF

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Publication number
ES2527418T3
ES2527418T3 ES05787278.0T ES05787278T ES2527418T3 ES 2527418 T3 ES2527418 T3 ES 2527418T3 ES 05787278 T ES05787278 T ES 05787278T ES 2527418 T3 ES2527418 T3 ES 2527418T3
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Prior art keywords
alkyl
pyridin
chlorobenzyl
fluorobenzyl
chloro
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Expired - Lifetime
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ES05787278.0T
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English (en)
Spanish (es)
Inventor
Hassan J. Imogai
José M. Cid-Núñez
Guillaume A. J. Duvey
Christelle M. Bolea
Vanthéa NHEM
Terry Patrick Finn
Emmanuel Ch. Le Poul
Jean-Philippe F.C. Rocher
Robert J. Lütjens
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Addex Pharmaceuticals SA
Janssen Pharmaceuticals Inc
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Addex Pharmaceuticals SA
Janssen Pharmaceuticals Inc
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES05787278.0T 2004-09-17 2005-09-16 Derivados de piridinona novedosos y su uso como moduladores alostéricos positivos de receptores mGluR2 Expired - Lifetime ES2527418T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
GB0420722 2004-09-17
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

Publications (1)

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ES2527418T3 true ES2527418T3 (es) 2015-01-23

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ES05787278.0T Expired - Lifetime ES2527418T3 (es) 2004-09-17 2005-09-16 Derivados de piridinona novedosos y su uso como moduladores alostéricos positivos de receptores mGluR2

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US (2) US8399493B2 (enExample)
EP (1) EP1799646B1 (enExample)
JP (2) JP5179873B2 (enExample)
KR (1) KR20070085262A (enExample)
CN (1) CN101061098B (enExample)
AU (1) AU2005284098B2 (enExample)
BR (1) BRPI0515412A (enExample)
CA (1) CA2581144C (enExample)
EA (1) EA013740B1 (enExample)
ES (1) ES2527418T3 (enExample)
GB (1) GB0420722D0 (enExample)
IL (1) IL181742A0 (enExample)
MX (1) MX2007003006A (enExample)
NO (1) NO20071660L (enExample)
NZ (1) NZ554041A (enExample)
SG (1) SG155938A1 (enExample)
TW (1) TW200633982A (enExample)
UA (1) UA98098C2 (enExample)
WO (1) WO2006030032A1 (enExample)
ZA (1) ZA200703088B (enExample)

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Publication number Priority date Publication date Assignee Title
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
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