MX2007003006A - Derivados de piridinona novedosos y su uso como moduladores alostericos positivos de receptores metabotropicos-subtipo 2. - Google Patents

Derivados de piridinona novedosos y su uso como moduladores alostericos positivos de receptores metabotropicos-subtipo 2.

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Publication number
MX2007003006A
MX2007003006A MX2007003006A MX2007003006A MX2007003006A MX 2007003006 A MX2007003006 A MX 2007003006A MX 2007003006 A MX2007003006 A MX 2007003006A MX 2007003006 A MX2007003006 A MX 2007003006A MX 2007003006 A MX2007003006 A MX 2007003006A
Authority
MX
Mexico
Prior art keywords
alkyl
cycloalkyl
alkynyl
alkenyl
alkylcycloalkyl
Prior art date
Application number
MX2007003006A
Other languages
English (en)
Spanish (es)
Inventor
Jose Maria Cid-Nunez
Hassan Julien Imogai
Guillaume Albert Jacques Duvey
Christelle Martine Bolea
Vanthea Nhem
Terry Patrick Finn
Emmanuel Christian Le Poul
Jean-Philippe Francois Rocher
Robert Johannes Lutjens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2007003006A publication Critical patent/MX2007003006A/es

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
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  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
MX2007003006A 2004-09-17 2005-09-16 Derivados de piridinona novedosos y su uso como moduladores alostericos positivos de receptores metabotropicos-subtipo 2. MX2007003006A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

Publications (1)

Publication Number Publication Date
MX2007003006A true MX2007003006A (es) 2007-07-24

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MX2007003006A MX2007003006A (es) 2004-09-17 2005-09-16 Derivados de piridinona novedosos y su uso como moduladores alostericos positivos de receptores metabotropicos-subtipo 2.

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US (2) US8399493B2 (enExample)
EP (1) EP1799646B1 (enExample)
JP (2) JP5179873B2 (enExample)
KR (1) KR20070085262A (enExample)
CN (1) CN101061098B (enExample)
AU (1) AU2005284098B2 (enExample)
BR (1) BRPI0515412A (enExample)
CA (1) CA2581144C (enExample)
EA (1) EA013740B1 (enExample)
ES (1) ES2527418T3 (enExample)
GB (1) GB0420722D0 (enExample)
IL (1) IL181742A0 (enExample)
MX (1) MX2007003006A (enExample)
NO (1) NO20071660L (enExample)
NZ (1) NZ554041A (enExample)
SG (1) SG155938A1 (enExample)
TW (1) TW200633982A (enExample)
UA (1) UA98098C2 (enExample)
WO (1) WO2006030032A1 (enExample)
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SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
US7728013B2 (en) 2005-05-10 2010-06-01 Intermune, Inc. Method of modulating stress-activated protein kinase system
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