SI3191470T1 - Modulatorji COT in postopki njihove uporabe - Google Patents

Modulatorji COT in postopki njihove uporabe

Info

Publication number
SI3191470T1
SI3191470T1 SI201630202T SI201630202T SI3191470T1 SI 3191470 T1 SI3191470 T1 SI 3191470T1 SI 201630202 T SI201630202 T SI 201630202T SI 201630202 T SI201630202 T SI 201630202T SI 3191470 T1 SI3191470 T1 SI 3191470T1
Authority
SI
Slovenia
Prior art keywords
methods
cot
modulators
cot modulators
Prior art date
Application number
SI201630202T
Other languages
English (en)
Inventor
Elizabeth M. Bacon
Gayatri Balan
Chien-Hung Chou
Christopher T. Clark
Jeromy J. Cottell
Musong Kim
Thorsten A. Kirschberg
John O. Link
Gary Phillips
Scott D. Schroeder
Neil H. Squires
Kirk L. Stevens
James G. Taylor
William J. Watkins
Nathan E. Wright
Sheila M. Zipfel
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of SI3191470T1 publication Critical patent/SI3191470T1/sl

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D495/04—Ortho-condensed systems
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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SI201630202T 2015-07-06 2016-06-30 Modulatorji COT in postopki njihove uporabe SI3191470T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562189158P 2015-07-06 2015-07-06
US201562269060P 2015-12-17 2015-12-17
EP16738976.6A EP3191470B1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof
PCT/US2016/040520 WO2017007689A1 (en) 2015-07-06 2016-06-30 Cot modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
SI3191470T1 true SI3191470T1 (sl) 2019-04-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SI201631197T SI3456717T1 (sl) 2015-07-06 2016-06-30 4,6-diamino-kinolin-3-karbonitrilni derivat kot modulator cancer osaka thyroid (COT) za zdravljenje vnetne bolezni
SI201630202T SI3191470T1 (sl) 2015-07-06 2016-06-30 Modulatorji COT in postopki njihove uporabe

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SI201631197T SI3456717T1 (sl) 2015-07-06 2016-06-30 4,6-diamino-kinolin-3-karbonitrilni derivat kot modulator cancer osaka thyroid (COT) za zdravljenje vnetne bolezni

Country Status (39)

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US (6) US20170008905A1 (sl)
EP (3) EP3191470B1 (sl)
JP (5) JP6430060B2 (sl)
KR (5) KR20220129667A (sl)
CN (3) CN109879859B (sl)
AU (4) AU2016290820B2 (sl)
CA (1) CA2971640C (sl)
CL (1) CL2017003356A1 (sl)
CO (1) CO2017013351A2 (sl)
CR (1) CR20170599A (sl)
CU (1) CU20170172A7 (sl)
CY (1) CY1121750T1 (sl)
DK (1) DK3191470T3 (sl)
DO (1) DOP2017000311A (sl)
EA (1) EA036788B1 (sl)
EC (1) ECSP17084635A (sl)
ES (2) ES2734713T3 (sl)
HR (1) HRP20190853T1 (sl)
HU (1) HUE043310T2 (sl)
IL (4) IL274568B (sl)
LT (1) LT3191470T (sl)
MA (1) MA39422B1 (sl)
ME (1) ME03425B (sl)
MX (1) MX370984B (sl)
MY (1) MY196173A (sl)
NZ (2) NZ738525A (sl)
PE (1) PE20180462A1 (sl)
PH (2) PH12018500031B1 (sl)
PL (2) PL3456717T3 (sl)
PT (2) PT3191470T (sl)
RS (1) RS58639B1 (sl)
SA (1) SA517381350B1 (sl)
SG (1) SG11201702041PA (sl)
SI (2) SI3456717T1 (sl)
SV (1) SV2017005605A (sl)
TW (3) TWI699361B (sl)
UA (1) UA123010C2 (sl)
UY (1) UY36771A (sl)
WO (1) WO2017007689A1 (sl)

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Publication number Priority date Publication date Assignee Title
ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
PT3319955T (pt) 2015-07-06 2021-01-05 Gilead Sciences Inc 6-amino-quinolino-3-carbonitrilos como moduladores de cot
DK3191470T3 (en) * 2015-07-06 2019-04-15 Gilead Sciences Inc COT MODULATORS AND METHODS OF USING THEREOF
WO2018005435A1 (en) 2016-06-30 2018-01-04 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof
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