SV2017005605A - Moduladores cot y metodos de uso de los mismos - Google Patents
Moduladores cot y metodos de uso de los mismosInfo
- Publication number
- SV2017005605A SV2017005605A SV2017005605A SV2017005605A SV2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A
- Authority
- SV
- El Salvador
- Prior art keywords
- methods
- same
- cot
- modulators
- cot modulators
- Prior art date
Links
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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Abstract
LA PRESENTE DIVULGACIÓN SE REFIERE EN GENERAL A MODULADORES DE COT (CÁNCER DE TIROIDES OSAKA) Y MÉTODOS DE USO Y PRODUCCIÓN DE LOS MISMOS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201562189158P | 2015-07-06 | 2015-07-06 | |
US201562269060P | 2015-12-17 | 2015-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
SV2017005605A true SV2017005605A (es) | 2018-07-18 |
Family
ID=56411943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SV2017005605A SV2017005605A (es) | 2015-07-06 | 2017-12-22 | Moduladores cot y metodos de uso de los mismos |
Country Status (40)
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US (7) | US20170008905A1 (es) |
EP (3) | EP3191470B1 (es) |
JP (6) | JP6430060B2 (es) |
KR (5) | KR20240008398A (es) |
CN (3) | CN107922390B (es) |
AU (5) | AU2016290820B2 (es) |
BR (1) | BR102016015656B1 (es) |
CA (1) | CA2971640C (es) |
CL (1) | CL2017003356A1 (es) |
CO (1) | CO2017013351A2 (es) |
CR (1) | CR20170599A (es) |
CU (1) | CU20170172A7 (es) |
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DK (1) | DK3191470T3 (es) |
DO (1) | DOP2017000311A (es) |
EA (1) | EA036788B1 (es) |
EC (1) | ECSP17084635A (es) |
ES (2) | ES2734713T3 (es) |
HR (1) | HRP20190853T1 (es) |
HU (1) | HUE043310T2 (es) |
IL (4) | IL293770B2 (es) |
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NZ (2) | NZ750707A (es) |
PE (1) | PE20180462A1 (es) |
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PL (2) | PL3456717T3 (es) |
PT (2) | PT3191470T (es) |
RS (1) | RS58639B1 (es) |
SA (1) | SA517381350B1 (es) |
SG (1) | SG11201702041PA (es) |
SI (2) | SI3191470T1 (es) |
SV (1) | SV2017005605A (es) |
TW (3) | TWI699361B (es) |
UA (1) | UA123010C2 (es) |
UY (1) | UY36771A (es) |
WO (1) | WO2017007689A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9540343B2 (en) | 2011-07-06 | 2017-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
AU2016289817B2 (en) | 2015-07-06 | 2019-01-31 | Gilead Sciences, Inc. | 6-amino-quinoline-3-carbonitrils as Cot modulators |
KR20240008398A (ko) | 2015-07-06 | 2024-01-18 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
WO2018005435A1 (en) | 2016-06-30 | 2018-01-04 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as cot modulators and methods of use thereof |
KR102180740B1 (ko) * | 2016-08-19 | 2020-11-20 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 바이러스 감염의 예방적 또는 치유적 치료에 유용한 치료 화합물 |
EA036921B1 (ru) * | 2017-02-10 | 2021-01-15 | Джилид Сайэнс, Инк. | Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич |
CN108794516A (zh) * | 2017-04-26 | 2018-11-13 | 上海时莱生物技术有限公司 | 硼酸和硼酸酯类化合物及其制备方法和用途 |
AR112413A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas sólidas de un inhibidor de la cápside del vih |
AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
EP3689866A4 (en) * | 2017-09-26 | 2021-07-07 | Nippon Soda Co., Ltd. | QUINOLINE COMPOUND AND BACTERICIDAL AGENT FOR AGRICULTURE AND HORTICULTURE |
JP7083398B2 (ja) | 2018-02-15 | 2022-06-10 | ギリアード サイエンシーズ, インコーポレイテッド | ピリジン誘導体およびhiv感染を処置するためのその使用 |
KR102587504B1 (ko) | 2018-02-16 | 2023-10-11 | 길리애드 사이언시즈, 인코포레이티드 | 레트로비리다에 바이러스 감염의 치료에 유용한 치료 화합물을 제조하기 위한 방법 및 중간체 |
WO2019168874A1 (en) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
CN110294660B (zh) * | 2018-03-23 | 2021-09-24 | 中国农业大学 | 一种含碳碳三键和/或碳氮三键的不饱和有机化合物的还原氘化方法 |
CN108658996A (zh) * | 2018-06-25 | 2018-10-16 | 中国药科大学 | 一种氘代Fiduxosin的制备方法 |
TW202425967A (zh) | 2018-07-16 | 2024-07-01 | 美商基利科學股份有限公司 | 用於治療hiv之蛋白殼抑制劑 |
TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
HRP20240297T1 (hr) | 2019-08-29 | 2024-05-10 | Idorsia Pharmaceuticals Ltd | Derivati alfa-d-galaktopiranozida |
JP2023502530A (ja) | 2019-11-26 | 2023-01-24 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv予防のためのカプシド阻害剤 |
WO2021202224A1 (en) * | 2020-03-30 | 2021-10-07 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
US11845737B2 (en) | 2020-04-02 | 2023-12-19 | Gilead Sciences, Inc. | Process for preparing a Cot inhibitor compound |
US11680064B2 (en) | 2020-06-25 | 2023-06-20 | Gilead Sciences, Inc. | Capsid inhibitors for the treatment of HIV |
MX2023010241A (es) | 2021-03-03 | 2023-09-12 | Idorsia Pharmaceuticals Ltd | Derivados de alfa-d-galatopiranosido triazolil-metil sustituidos. |
TW202304435A (zh) * | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
EP4352058A1 (en) * | 2021-06-11 | 2024-04-17 | Neuronascent, Inc. | Methods and compositions for lipid formulation of lipophilic small molecule therapies of the heterocyclic type |
KR20240117588A (ko) | 2021-12-03 | 2024-08-01 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 바이러스 감염 치료용 화합물 |
CA3235937A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3930837A (en) | 1971-12-31 | 1976-01-06 | Ici Australia Limited | 3-chloro-5-acetamidaisoquinoline as a herbicide |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
NL7800191A (nl) | 1977-01-10 | 1978-07-12 | Ciba Geigy | Anthelmintisch preparaat. |
US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
JP2634438B2 (ja) | 1988-07-26 | 1997-07-23 | 三井東圧化学株式会社 | 不斉ビスオキサゾリルピリジン誘導体およびその製造方法 |
DE4014171A1 (de) | 1990-05-03 | 1991-11-07 | Basf Ag | Cyanochinolinverbindungen |
GB9310700D0 (en) | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Novel composition |
UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
KR20010022781A (ko) | 1997-08-28 | 2001-03-26 | 도쿠시마 히데이치 | 시아노아크릴레이트 화합물을 함유하는 공업용 항균·항진균제, 살조제(殺藻劑) 및 생물 부착 방지제 |
JP5035813B2 (ja) | 1998-07-10 | 2012-09-26 | マサチューセッツ インスティテュート オブ テクノロジー | 金属用のリガンドおよびそれらに基づいて改善された金属触媒法 |
SI2253620T1 (sl) | 1998-09-29 | 2014-06-30 | Wyeth Holdings Llc | Substituirani 3-cianokinolini kot inhibitorji protein tirozin-kinaz |
EP1485085A4 (en) | 2002-03-20 | 2007-03-14 | Bristol Myers Squibb Co | PHOSPHATE PRODRUGS OF FLUORO XINDOLS |
CN100395237C (zh) | 2003-03-03 | 2008-06-18 | 弗·哈夫曼-拉罗切有限公司 | 用作5-ht6调节剂的2,5-取代的四氢异喹啉 |
RU2345069C2 (ru) | 2003-08-19 | 2009-01-27 | Уайт Холдингз Корпорейшн | Способ получения 4-амино-3-хинолинкарбонитрилов |
US7399865B2 (en) * | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
TW200529846A (en) * | 2004-02-20 | 2005-09-16 | Wyeth Corp | 3-quinolinecarbonitrile protein kinase inhibitors |
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
AU2006247520A1 (en) * | 2005-05-18 | 2006-11-23 | Wyeth | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same |
CA2608362A1 (en) * | 2005-05-18 | 2006-11-23 | Wyeth | 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same |
UA94246C2 (ru) | 2005-10-28 | 2011-04-26 | Эбботт Леборетриз | Производные индазола, которые ингибируют рецептор trpv1 |
EP2001480A4 (en) | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
WO2008055950A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008092292A1 (en) | 2007-01-17 | 2008-08-07 | The Hong Kong University Of Science And Technology | Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2 |
GB0820856D0 (en) | 2008-11-14 | 2008-12-24 | Univ Leuven Kath | Novel inhibitors of flavivirus replication |
TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
GB0922302D0 (en) * | 2009-12-22 | 2010-02-03 | Imp Innovations Ltd | Compounds |
AU2011224410B2 (en) | 2010-03-09 | 2015-05-28 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
ES2639407T3 (es) | 2010-06-09 | 2017-10-26 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd. | Derivados de cianoquinolina |
ES2693152T3 (es) | 2011-05-10 | 2018-12-07 | Kyowa Hakko Kirin Co., Ltd. | Compuesto de pirimido-diazepinona |
CN103957711A (zh) | 2011-07-04 | 2014-07-30 | 拜耳知识产权有限责任公司 | 取代的异喹啉酮、异喹啉二酮、异喹啉三酮和二氢异喹啉酮或其各自的盐作为活性剂对抗植物非生物胁迫的用途 |
EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
BR112014009927B1 (pt) | 2011-10-27 | 2022-07-05 | Taisho Pharmaceutical Co., Ltd | Derivado de azol, composição farmacêutica que o compreende e uso do mesmo |
UA123760C2 (uk) | 2011-11-11 | 2021-06-02 | Гіліад Аполло, Ллс | Сполука (варіанти) та композиція, що містить сполуку |
UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
CN103483363B (zh) | 2012-06-13 | 2016-12-21 | 上海赛迦化工产品有限公司 | 多样性的手性氨基硼酸及其制备方法和应用 |
CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
CN103408572B (zh) | 2013-07-12 | 2015-12-02 | 上海工程技术大学 | 手性氨基硼酸衍生物及其制备方法和应用 |
CN108947867A (zh) | 2013-12-12 | 2018-12-07 | 卡利拉制药公司 | 双环烷基化合物及合成 |
CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
EP3166938A4 (en) * | 2014-07-11 | 2018-01-17 | Northwestern University | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase |
EP3193855B1 (en) | 2014-09-17 | 2021-05-19 | Recurium IP Holdings, LLC | Bicyclic compounds |
EP3524243A1 (en) | 2014-09-24 | 2019-08-14 | Gilead Sciences, Inc. | Methods of treating liver disease |
PT3237404T (pt) | 2014-12-23 | 2021-01-19 | Gilead Sciences Inc | Processos de preparação de inibidores ask1 |
MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
EA201892625A1 (ru) | 2015-01-09 | 2019-07-31 | Джилид Аполло, Ллс | КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ |
US10193384B2 (en) | 2015-01-16 | 2019-01-29 | 3M Innovative Properties Company | Systems and methods for selecting grid actions to improve grid outcomes |
KR20240008398A (ko) | 2015-07-06 | 2024-01-18 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
AU2016289817B2 (en) * | 2015-07-06 | 2019-01-31 | Gilead Sciences, Inc. | 6-amino-quinoline-3-carbonitrils as Cot modulators |
US11149008B2 (en) | 2015-12-31 | 2021-10-19 | HitGen, Inc. | Sulfamide derivatives and preparation method and use thereof |
EP3423456B1 (en) | 2016-03-02 | 2023-12-27 | Gilead Apollo, LLC | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
JP6738895B2 (ja) | 2016-06-21 | 2020-08-12 | Phcホールディングス株式会社 | カタラーゼ阻害剤及びカタラーゼ阻害剤を用いるアナライトの測定方法 |
WO2018005435A1 (en) | 2016-06-30 | 2018-01-04 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as cot modulators and methods of use thereof |
CN106512014A (zh) | 2016-10-27 | 2017-03-22 | 武汉大学 | 肿瘤进展位点2在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
PL3589636T3 (pl) | 2017-03-03 | 2024-02-19 | Gilead Sciences, Inc. | Sposoby wytwarzania inhibitorów acc i ich form stałych |
PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
KR20190132515A (ko) | 2017-04-12 | 2019-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하는 방법 |
CN111182904A (zh) | 2017-10-06 | 2020-05-19 | 吉利德科学公司 | 包含acc抑制剂的组合治疗 |
JP2022519906A (ja) | 2019-02-19 | 2022-03-25 | ギリアード サイエンシーズ, インコーポレイテッド | Fxrアゴニストの固体形態 |
EP3934615A4 (en) | 2019-03-08 | 2023-01-25 | The Regents Of The University Of California | COMPOSITIONS AND METHODS FOR TREATMENT OF ACNE |
TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
WO2021202224A1 (en) | 2020-03-30 | 2021-10-07 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
US11845737B2 (en) | 2020-04-02 | 2023-12-19 | Gilead Sciences, Inc. | Process for preparing a Cot inhibitor compound |
TW202304435A (zh) | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
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