ES2498095T3 - Composición farmacéutica que comprende fentanil para el tratamiento del cáncer o el dolor intercurrente o agudo mediante administración sublingual - Google Patents

Composición farmacéutica que comprende fentanil para el tratamiento del cáncer o el dolor intercurrente o agudo mediante administración sublingual Download PDF

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Publication number
ES2498095T3
ES2498095T3 ES10001408.3T ES10001408T ES2498095T3 ES 2498095 T3 ES2498095 T3 ES 2498095T3 ES 10001408 T ES10001408 T ES 10001408T ES 2498095 T3 ES2498095 T3 ES 2498095T3
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Prior art keywords
fentanyl
pharmaceutical composition
intercurrent
sublingual administration
cancer
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Expired - Lifetime
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ES10001408.3T
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English (en)
Inventor
Anders Pettersson
Christer Nyström
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Orexo AB
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Orexo AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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Abstract

Una composición farmacéutica en monodosis que comprende una cantidad farmacéuticamente eficaz de fentanil o una de sus sales farmacéuticamente aceptables en forma de partículas, y partículas de un agente promotor de bioadhesión y mucoadhesión que tiene una tamaño de partícula comprendido entre 1 y 100 μm para su uso en un método para tratar el dolor agudo o intercurrente, donde dicho método comprende la administración sublingual de esa composición.

Description

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Claims (1)

  1. imagen1
ES10001408.3T 1998-09-24 1999-09-24 Composición farmacéutica que comprende fentanil para el tratamiento del cáncer o el dolor intercurrente o agudo mediante administración sublingual Expired - Lifetime ES2498095T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803240 1998-09-24
SE9803240A SE9803240D0 (sv) 1998-09-24 1998-09-24 A pharmaceutical composition having a rapid action

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ES99952867T Expired - Lifetime ES2289829T3 (es) 1998-09-24 1999-09-24 Tratamiento de desordenes agudos por administracion sublingual de una composicion farmaceutica.
ES10001406.7T Expired - Lifetime ES2507579T3 (es) 1998-09-24 1999-09-24 Composición farmacéutica para el tratamiento del insomnio mediante administración sublingual
ES05077875T Expired - Lifetime ES2433930T3 (es) 1998-09-24 1999-09-24 Composición farmacéutica para administración sublingual
ES10001408.3T Expired - Lifetime ES2498095T3 (es) 1998-09-24 1999-09-24 Composición farmacéutica que comprende fentanil para el tratamiento del cáncer o el dolor intercurrente o agudo mediante administración sublingual

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ES99952867T Expired - Lifetime ES2289829T3 (es) 1998-09-24 1999-09-24 Tratamiento de desordenes agudos por administracion sublingual de una composicion farmaceutica.
ES10001406.7T Expired - Lifetime ES2507579T3 (es) 1998-09-24 1999-09-24 Composición farmacéutica para el tratamiento del insomnio mediante administración sublingual
ES05077875T Expired - Lifetime ES2433930T3 (es) 1998-09-24 1999-09-24 Composición farmacéutica para administración sublingual

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CZ306387B6 (cs) 2016-12-28
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