ES2338789T3 - Antagonistas macrociclicos del receptor de motilina. - Google Patents
Antagonistas macrociclicos del receptor de motilina. Download PDFInfo
- Publication number
- ES2338789T3 ES2338789T3 ES04737852T ES04737852T ES2338789T3 ES 2338789 T3 ES2338789 T3 ES 2338789T3 ES 04737852 T ES04737852 T ES 04737852T ES 04737852 T ES04737852 T ES 04737852T ES 2338789 T3 ES2338789 T3 ES 2338789T3
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- Prior art keywords
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- motilin
- compound
- syndrome
- nmr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
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- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
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- C07—ORGANIC CHEMISTRY
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- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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Landscapes
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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-
2004
- 2004-06-18 EP EP04737852A patent/EP1633774B1/en not_active Expired - Lifetime
- 2004-06-18 AT AT04737852T patent/ATE457995T1/de not_active IP Right Cessation
- 2004-06-18 CA CA2528375A patent/CA2528375C/en not_active Expired - Fee Related
- 2004-06-18 EP EP10001568.4A patent/EP2210612B1/en not_active Expired - Lifetime
- 2004-06-18 US US10/872,142 patent/US7521420B2/en not_active Expired - Lifetime
- 2004-06-18 DK DK04737852.6T patent/DK1633774T3/da active
- 2004-06-18 WO PCT/CA2004/000913 patent/WO2004111077A1/en active Search and Examination
- 2004-06-18 DE DE602004025569T patent/DE602004025569D1/de not_active Expired - Lifetime
- 2004-06-18 ES ES04737852T patent/ES2338789T3/es not_active Expired - Lifetime
- 2004-06-18 JP JP2006515603A patent/JP4928261B2/ja not_active Expired - Fee Related
-
2008
- 2008-11-19 US US12/273,638 patent/US9181298B2/en active Active
- 2008-11-19 US US12/273,648 patent/US8129561B2/en not_active Expired - Fee Related
-
2011
- 2011-02-28 US US13/036,484 patent/US8497242B2/en not_active Expired - Lifetime
-
2012
- 2012-03-05 US US13/411,959 patent/US20120226066A1/en not_active Abandoned
- 2012-03-05 US US13/412,148 patent/US20120226067A1/en not_active Abandoned
- 2012-03-05 US US13/412,009 patent/US20120226072A1/en not_active Abandoned
- 2012-03-05 US US13/411,979 patent/US20120165566A1/en not_active Abandoned
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2015
- 2015-10-01 US US14/873,056 patent/US10040751B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP4928261B2 (ja) | 2012-05-09 |
CA2528375C (en) | 2013-11-19 |
US20090137835A1 (en) | 2009-05-28 |
DK1633774T3 (da) | 2010-05-25 |
US20050054562A1 (en) | 2005-03-10 |
DE602004025569D1 (de) | 2010-04-01 |
US10040751B2 (en) | 2018-08-07 |
US20120226066A1 (en) | 2012-09-06 |
US20090240027A1 (en) | 2009-09-24 |
US20110245459A1 (en) | 2011-10-06 |
US20160221927A1 (en) | 2016-08-04 |
US8129561B2 (en) | 2012-03-06 |
ATE457995T1 (de) | 2010-03-15 |
US8497242B2 (en) | 2013-07-30 |
EP2210612A2 (en) | 2010-07-28 |
US20120226067A1 (en) | 2012-09-06 |
EP2210612A3 (en) | 2010-11-24 |
EP1633774A1 (en) | 2006-03-15 |
EP2210612B1 (en) | 2016-10-05 |
CA2528375A1 (en) | 2004-12-23 |
JP2007523853A (ja) | 2007-08-23 |
WO2004111077A1 (en) | 2004-12-23 |
US9181298B2 (en) | 2015-11-10 |
US7521420B2 (en) | 2009-04-21 |
EP1633774B1 (en) | 2010-02-17 |
US20120226072A1 (en) | 2012-09-06 |
US20120165566A1 (en) | 2012-06-28 |
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