PL1661890T3 - Związek aktywujący PPAR oraz kompozycja farmaceutyczna zawierająca ten związek - Google Patents

Związek aktywujący PPAR oraz kompozycja farmaceutyczna zawierająca ten związek

Info

Publication number
PL1661890T3
PL1661890T3 PL04772699T PL04772699T PL1661890T3 PL 1661890 T3 PL1661890 T3 PL 1661890T3 PL 04772699 T PL04772699 T PL 04772699T PL 04772699 T PL04772699 T PL 04772699T PL 1661890 T3 PL1661890 T3 PL 1661890T3
Authority
PL
Poland
Prior art keywords
ppar
pharmaceutical composition
composition containing
containing same
activating compound
Prior art date
Application number
PL04772699T
Other languages
English (en)
Inventor
Yukiyoshi Yamazaki
Tsutomu Toma
Masahiro Nishikawa
Hidefumi Ozawa
Ayumu Okuda
Takaaki Araki
Kazutoyo Abe
Soichi Oda
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of PL1661890T3 publication Critical patent/PL1661890T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL04772699T 2003-09-03 2004-09-02 Związek aktywujący PPAR oraz kompozycja farmaceutyczna zawierająca ten związek PL1661890T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49935703P 2003-09-03 2003-09-03
JP2003317353 2003-09-09
JP2003364817 2003-10-24
EP04772699A EP1661890B1 (en) 2003-09-03 2004-09-02 Ppar-activating compound and pharmaceutical composition containing same
PCT/JP2004/012750 WO2005023777A1 (ja) 2003-09-03 2004-09-02 Ppar活性化化合物及びこれを含有する医薬組成物

Publications (1)

Publication Number Publication Date
PL1661890T3 true PL1661890T3 (pl) 2011-06-30

Family

ID=34279568

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04772699T PL1661890T3 (pl) 2003-09-03 2004-09-02 Związek aktywujący PPAR oraz kompozycja farmaceutyczna zawierająca ten związek

Country Status (17)

Country Link
US (2) US7109226B2 (pl)
EP (1) EP1661890B1 (pl)
JP (2) JP4226005B2 (pl)
KR (1) KR101160808B1 (pl)
AU (1) AU2004270538C1 (pl)
BR (1) BRPI0413991B8 (pl)
CA (1) CA2535749C (pl)
CY (1) CY1111867T1 (pl)
EA (1) EA009374B1 (pl)
HR (1) HRP20110009T1 (pl)
IL (1) IL173639A (pl)
MX (1) MXPA06002435A (pl)
NO (1) NO335823B1 (pl)
NZ (1) NZ545692A (pl)
PL (1) PL1661890T3 (pl)
TW (1) TWI324599B (pl)
WO (1) WO2005023777A1 (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
AU2004261329B2 (en) * 2003-07-31 2011-10-27 Ocera Therapeutics, Inc. Spatially-defined macrocyclic compounds useful for drug discovery
US7398116B2 (en) 2003-08-11 2008-07-08 Veran Medical Technologies, Inc. Methods, apparatuses, and systems useful in conducting image guided interventions
US7301033B2 (en) * 2005-01-27 2007-11-27 Kowa Co., Ltd. PPAR-activating compound
EP1852426B1 (en) * 2005-02-23 2013-11-13 Kowa Company, Ltd. Process for production of optically active ppar-activating compound and intermediate of the same
US7538242B2 (en) 2005-03-01 2009-05-26 Kowa Co., Ltd. Optically active PPAR-activating compound intermediate and method for producing same
US7714141B2 (en) 2005-05-31 2010-05-11 Kowa Co., Ltd. Processes for production of optically active PPAR-activating compounds and intermediates for production thereof
EP1908747B1 (en) 2005-07-28 2012-01-04 Kowa Company, Ltd. Process for producing optically active 2-hydroxybutyric ester
US8088733B2 (en) * 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
WO2008094860A2 (en) 2007-01-30 2008-08-07 Allergan, Inc. Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
TWI407955B (zh) * 2007-03-29 2013-09-11 Kowa Co 高脂血症之預防及／或治療劑
US20120165377A1 (en) * 2009-09-28 2012-06-28 Kowa Co., Ltd. Agent for reducing visceral fat weight
TWI425948B (zh) * 2012-01-20 2014-02-11 Compositions for the inhibition or killing of Porphyromonas gingivalis and their use for the alleviation or treatment of periodontal disease and other diseases
SG11201501740XA (en) 2012-09-27 2015-04-29 Kowa Co Therapeutic agent for dyslipidemia
EP2980061A4 (en) 2013-03-29 2016-09-07 Kowa Co METHOD FOR IMPROVING THE OPTICAL PURITY OF 2-HYDROXYCARBOXYLIC ACID OR A DERIVATIVE THEREOF
TWI696462B (zh) 2013-07-10 2020-06-21 日商興和股份有限公司 非酒精性脂肪性肝疾病治療劑
CA2919817C (en) 2013-08-28 2021-05-25 Kowa Company, Ltd. Compositions comprising pemafibrate and an omega-3 fatty acid useful in the treatment of dyslipidemia
EP3091970B1 (en) * 2014-01-10 2020-10-28 Rgenix, Inc. Lxr agonists and uses thereof
TW201618777A (zh) * 2014-09-26 2016-06-01 興和股份有限公司 脂質異常症治療劑
TWI691331B (zh) * 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
JP6850730B2 (ja) * 2015-11-12 2021-03-31 学校法人 聖マリアンナ医科大学 緑内障予防治療剤
SI3275438T1 (sl) 2016-07-29 2021-05-31 Kowa Company, Ltd. Metode preprečevanja kardiovaskularnih dogodkov pri dislipidemični populaciji z rezidualnim tveganjem
JP2019059673A (ja) * 2016-08-25 2019-04-18 興和株式会社 Ｐｂｃの治療剤
JPWO2018037593A1 (ja) 2016-08-25 2019-06-20 興和株式会社 Ｐｂｃの治療剤
ES3026786T3 (en) 2017-01-11 2025-06-12 Kowa Co Pemafibrate in combination with a sglt2 inhibitor for the prophylactic or therapeutic treatment of liver diseases nonalcoholic fatty liver disease
US10314825B2 (en) 2017-02-24 2019-06-11 Kowa Company, Ltd. Agent for treatment of PBC
HUE069648T2 (hu) 2017-06-30 2025-03-28 Kowa Co Gyógyszerészeti készítmény
WO2019004447A1 (ja) * 2017-06-30 2019-01-03 興和株式会社 医薬組成物
JP7007379B2 (ja) * 2017-06-30 2022-02-10 興和株式会社 医薬組成物
US11759456B2 (en) 2017-06-30 2023-09-19 Kowa Company, Ltd. Pharmaceutical composition
CN110831592A (zh) 2017-06-30 2020-02-21 兴和株式会社 医药
KR102512518B1 (ko) 2017-06-30 2023-03-21 교와 가부시키가이샤 페마피브레이트를 함유하는 의약
US11298340B2 (en) * 2017-06-30 2022-04-12 Kowa Company, Ltd. Pharmaceutical composition
WO2019004453A1 (ja) 2017-06-30 2019-01-03 興和株式会社 医薬品
JP6959049B2 (ja) * 2017-06-30 2021-11-02 興和株式会社 新規低アルブミン血症改善薬
KR20200024165A (ko) 2017-06-30 2020-03-06 교와 가부시키가이샤 의약 조성물
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
CA3085951C (en) * 2017-12-21 2022-10-11 Kowa Company, Ltd. Methods of treatment of hypertriglyceridemia
US11446282B2 (en) 2017-12-21 2022-09-20 Kowa Company, Ltd. Methods of treating mixed dyslipidemia and hypertriglycertdemia
WO2019133462A1 (en) 2017-12-27 2019-07-04 Teva Pharmaceuticals International Gmbh Solid state forms of pemafibrate
WO2019216313A1 (ja) 2018-05-08 2019-11-14 国立大学法人岡山大学 心血管疾患に有用な医薬
JP2020105174A (ja) * 2018-12-27 2020-07-09 興和株式会社 医薬組成物
EP3903780A4 (en) * 2018-12-27 2023-01-18 Kowa Company, Ltd. MEDICAL DEVICE
US20220096443A1 (en) * 2018-12-27 2022-03-31 Kowa Company, Ltd. Pharmaceutical composition
US20220054458A1 (en) 2018-12-27 2022-02-24 Kowa Company, Ltd. Pharmaceutical preparation
PL4073025T3 (pl) 2019-12-13 2024-09-16 Inspirna, Inc. Sole metali i ich zastosowania
WO2022224962A1 (ja) 2021-04-20 2022-10-27 興和株式会社 脂質異常症又は心臓血管病の予防・治療のための組合せ医薬
AU2022264289A1 (en) 2021-04-28 2023-11-02 Kowa Company, Ltd. Blood carnitine-increasing agent
US20250221965A1 (en) 2022-03-31 2025-07-10 The Jikei University Therapeutic agent for respiratory disease
EP4552642A1 (en) 2022-07-06 2025-05-14 Kowa Company, Ltd. Agent for reducing blood myostatin level
TW202408500A (zh) 2022-07-15 2024-03-01 日商興和股份有限公司 血中ｌｄｌ膽固醇降低劑
WO2024201358A1 (en) * 2023-03-31 2024-10-03 Ami Lifesciences Private Limited A process for the preparation of pemafibrate and intermediates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6025425B2 (ja) * 1975-03-06 1985-06-18 藤沢薬品工業株式会社 置換フエノキシ脂肪酸類の合成法
JPS593465B2 (ja) * 1974-06-04 1984-01-24 藤沢薬品工業株式会社 チカンアミノアルキルチカンフエノキシカルボンサンルイノ セイゾウホウ
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
WO2002046176A1 (en) * 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Ppar (peroxisome proliferator activated receptor) activators
DE10151390A1 (de) * 2001-10-18 2003-05-08 Bayer Ag Essigsäurederivate
EP1480957A1 (en) * 2002-03-01 2004-12-01 Smithkline Beecham Corporation Hppars activators
US6653334B1 (en) * 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
EA009374B1 (ru) 2007-12-28
HRP20110009T1 (hr) 2011-03-31
US7183295B2 (en) 2007-02-27
BRPI0413991B1 (pt) 2018-09-18
EP1661890A1 (en) 2006-05-31
JP4226005B2 (ja) 2009-02-18
AU2004270538B2 (en) 2009-07-16
IL173639A0 (en) 2006-07-05
HK1093975A1 (zh) 2007-03-16
AU2004270538C1 (en) 2010-01-14
JP2009114185A (ja) 2009-05-28
US7109226B2 (en) 2006-09-19
TW200524884A (en) 2005-08-01
EP1661890A4 (en) 2008-12-03
BRPI0413991B8 (pt) 2021-05-25
US20060189667A1 (en) 2006-08-24
KR101160808B1 (ko) 2012-06-29
NZ545692A (en) 2009-02-28
CA2535749C (en) 2011-11-01
KR20060119890A (ko) 2006-11-24
TWI324599B (en) 2010-05-11
NO335823B1 (no) 2015-02-23
EP1661890B1 (en) 2011-01-05
AU2004270538A1 (en) 2005-03-17
JP4931893B2 (ja) 2012-05-16
MXPA06002435A (es) 2006-06-20
IL173639A (en) 2010-12-30
US20050101636A1 (en) 2005-05-12
JPWO2005023777A1 (ja) 2007-11-01
WO2005023777A1 (ja) 2005-03-17
BRPI0413991A (pt) 2006-11-07
EA200600527A1 (ru) 2006-08-25
NO20060654L (no) 2006-04-26
CY1111867T1 (el) 2015-11-04
CA2535749A1 (en) 2005-03-17

Similar Documents

Publication Publication Date Title
IL173639A (en) Ppar-activating compound and pharmaceutical composition containing same
IL174128A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL197889A (en) Pyridylvinylazacyclopentane compound and pharmaceutical compositions comprising same
IL173602A0 (en) Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the same
IL173627A0 (en) 2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives and pharmaceutical compositions containing the same
IL164455A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL173051A0 (en) N-glucoside derivatives and pharmaceutical compositions containing the same
IL171997A0 (en) Pyrrolodihydroisoquinoline derivatives and pharmaceutical compositions containing the same
AU2003291103A8 (en) Pharmaceutical composition
IL175214A0 (en) 2-cyanopyrrolidinecarboxamide derivatives and pharmaceutical compositions containing the same
IL165388A0 (en) Macrolide compounds and pharmaceutical compositions containing the same
IL164547A0 (en) Pharmaceutical composition
IL172159A0 (en) 2-oxo-pyridine derivatives and pharmaceutical compositions containing the same
GB0300427D0 (en) Pharmaceutical composition
IL165878A0 (en) Pharmaceutical composition
IL174249A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
GB0307866D0 (en) Pharmaceutical composition
EP1699458A4 (en) PHARMACEUTICAL COMPOSITION
GB0317663D0 (en) Pharmaceutical composition
IL176077A0 (en) 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
GB0300885D0 (en) Pharmaceutical composition
GB0306933D0 (en) Pharmaceutical composition
ZA200601232B (en) 3-Aryl-4-hydroxyfuranone compounds and pharmaceutical and veterinary compositions containing them
GB0307869D0 (en) Pharmaceutical composition
GB0307864D0 (en) Pharmaceutical composition