ES2294018T3 - Compuestos y metodos para el tratamiento y diagnostico de la infeccion con clamidias. - Google Patents
Compuestos y metodos para el tratamiento y diagnostico de la infeccion con clamidias. Download PDFInfo
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- ES2294018T3 ES2294018T3 ES01959114T ES01959114T ES2294018T3 ES 2294018 T3 ES2294018 T3 ES 2294018T3 ES 01959114 T ES01959114 T ES 01959114T ES 01959114 T ES01959114 T ES 01959114T ES 2294018 T3 ES2294018 T3 ES 2294018T3
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Classifications
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US620412 | 1984-06-14 | ||
| US09/620,412 US6448234B1 (en) | 1998-12-08 | 2000-07-20 | Compounds and methods for treatment and diagnosis of chlamydial infection |
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| AU5366099A (en) | 1998-08-20 | 2000-03-14 | Connaught Laboratories Limited | Nucleic acid molecules encoding inclusion membrane protein of (chlamydia) |
| EP1105489A1 (en) | 1998-08-20 | 2001-06-13 | Aventis Pasteur Limited | Nucleic acid molecules encoding pomp91a protein of chlamydia |
| US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
| US6649370B1 (en) | 1998-10-28 | 2003-11-18 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| US6607730B1 (en) | 1998-11-02 | 2003-08-19 | Aventis Pasteur Limited/Aventis Pasteur Limitee | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| AU3790900A (en) | 1998-12-01 | 2000-06-19 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| CN100365120C (zh) | 1998-12-08 | 2008-01-30 | 科里克萨有限公司 | 用于治疗及诊断衣原体感染的化合物和方法 |
| US20080213264A1 (en) * | 1998-12-08 | 2008-09-04 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6555115B1 (en) * | 1998-12-08 | 2003-04-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US20020061848A1 (en) * | 2000-07-20 | 2002-05-23 | Ajay Bhatia | Compounds and methods for treatment and diagnosis of chlamydial infection |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| US7297341B1 (en) | 1998-12-23 | 2007-11-20 | Sanofi Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| JP2002541766A (ja) | 1998-12-28 | 2002-12-10 | アベンティス、パストゥール、リミテッド | クラミジア抗原および対応するｄｎａ断片ならびにその使用 |
| US6808713B1 (en) | 1998-12-28 | 2004-10-26 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| GB9902555D0 (en) | 1999-02-05 | 1999-03-24 | Neutec Pharma Plc | Medicament |
| EP2172214A3 (en) | 1999-03-12 | 2011-03-16 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| WO2000066739A2 (en) | 1999-05-03 | 2000-11-09 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| CA2385325C (en) | 1999-09-20 | 2012-04-10 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| EP1240331B1 (en) | 1999-12-22 | 2010-04-07 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| AU2001255596A1 (en) | 2000-04-21 | 2001-11-07 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6919187B2 (en) * | 2000-04-21 | 2005-07-19 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| EP1282718B1 (en) | 2000-05-08 | 2006-12-20 | Sanofi Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| ATE440861T1 (de) | 2000-07-03 | 2009-09-15 | Novartis Vaccines & Diagnostic | Immunisierung gegen chlamydia pneumoniae |
| US7537772B1 (en) * | 2000-10-02 | 2009-05-26 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, gene sequence and the uses thereof |
| US7731980B2 (en) * | 2000-10-02 | 2010-06-08 | Emergent Product Development Gaithersburg Inc. | Chlamydia PMP proteins, gene sequences and uses thereof |
| US20030059896A1 (en) * | 2000-12-21 | 2003-03-27 | Shire Biochem Inc. | Novel chlamydia antigens and corresponding DNA fragments |
| GB2370838A (en) * | 2001-01-06 | 2002-07-10 | Benedikt Timmerman | Immunogenic complex |
| ES2386386T3 (es) | 2001-12-12 | 2012-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Inmunización contra Chlamydia trachomatis |
| GB0203403D0 (en) | 2002-02-13 | 2002-04-03 | Chiron Spa | Chlamydia cytotoxic-T cell epitopes |
| WO2005002619A2 (en) * | 2003-06-26 | 2005-01-13 | Chiron Corporation | Immunogenic compositions for chlamydia trachomatis |
| WO2005049837A1 (en) * | 2003-11-20 | 2005-06-02 | Aventis Pasteur Limited | Immunization against chlamydia infection |
| US8541007B2 (en) | 2005-03-31 | 2013-09-24 | Glaxosmithkline Biologicals S.A. | Vaccines against chlamydial infection |
| CN101184504A (zh) | 2005-03-31 | 2008-05-21 | 葛兰素史密丝克莱恩生物有限公司 | 针对衣原体感染的疫苗 |
| AU2006259858A1 (en) * | 2005-05-12 | 2006-12-28 | Novartis Vaccines And Diagnostics S.R.L. | Immunogenic compositions for Chlamydia trachomatis |
| WO2007030879A1 (en) * | 2005-09-13 | 2007-03-22 | Diatech Pty Ltd | Diagnostic markers and uses therefor |
| US9259463B2 (en) * | 2006-01-16 | 2016-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chlamydia vaccine |
| EP1970708A1 (de) * | 2007-03-07 | 2008-09-17 | Mikrogen Molekularbiologische Entwicklungs-GmbH | Biochip und Verfahren zum selektiven Nachweis von Chlamydia trachomatis-Infektionen |
| EP2162460A4 (en) * | 2007-06-14 | 2012-06-06 | Emergent Product Dev Gaithersburg Inc | VACCINES AGAINST CHLAMYDIA INFECTIONS |
| AU2008284352A1 (en) * | 2007-08-03 | 2009-02-12 | President And Fellows Of Harvard College | Chlamydia antigens |
| AU2008331800A1 (en) * | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
| WO2010100632A2 (en) | 2009-03-06 | 2010-09-10 | Novartis Ag | Chlamydia antigens |
| WO2011118496A1 (ja) | 2010-03-23 | 2011-09-29 | 和光純薬工業株式会社 | クラミジア・トラコマティス検出用プライマー及びプローブ、並びにこれを用いたクラミジア・トラコマティスの検出方法 |
| CA2849391A1 (en) * | 2010-10-20 | 2012-04-26 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| US20130095487A1 (en) * | 2011-10-18 | 2013-04-18 | University Of South Florida | Interferon-Gamma Response as a Diagnostic Test for Persistent Chlamydial Infections |
| CN109608550B (zh) * | 2012-12-05 | 2020-09-11 | 生控基因疫苗股份有限公司 | 用作诱发抗原特异性t细胞反应的免疫原性增强剂的融合蛋白 |
| CN113801191B (zh) * | 2021-08-18 | 2022-05-17 | 南京大学 | 一种检测衣原体的多肽探针及其应用 |
| AR132053A1 (es) | 2023-03-02 | 2025-05-21 | Sanofi Pasteur | Composiciones para su uso en el tratamiento de clamidia |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118469A (en) * | 1976-04-27 | 1978-10-03 | Research Corporation | Antigen for trachoma lymphogranuloma venereum (LGV) and non-gonococcal urethritis (NGU) |
| US4497899A (en) * | 1982-04-12 | 1985-02-05 | Abbott Laboratories | Immunoassay for Chlamydia trachomatis antigens |
| US4497900A (en) | 1982-04-12 | 1985-02-05 | Abbott Laboratories | Immunoassay for Neisseria gonorrhoeae antigens |
| US4497863A (en) * | 1984-03-07 | 1985-02-05 | Milliken Research Corporation | Laminated weft insertion fabric |
| DE3650571T2 (de) | 1985-01-14 | 1997-02-27 | Chiron Corp | Hauptprotein der Aussenmembran von Chlamydia |
| US5785973A (en) | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| EP0348725A3 (en) | 1988-06-29 | 1990-10-24 | Miles Inc. | Species-specific epitode of chlamydia trachomatis and antibodies that recognize the same |
| DE69020143T2 (de) | 1989-02-17 | 1996-01-25 | Chiron Mimotopes Pty Ltd | Verfahren zur verwendung und herstellung von peptiden. |
| US5869608A (en) * | 1989-03-17 | 1999-02-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins of Chlamydia trachomatis |
| US5166053A (en) * | 1990-02-23 | 1992-11-24 | Miles Inc. | Specimen adequacy control for chlamydia assays |
| JP3018553B2 (ja) * | 1990-05-08 | 2000-03-13 | 日立化成工業株式会社 | クラミジア・トラコマティス抗体測定方法及びクラミジア・トラコマティス感染症診断用製剤 |
| US5725863A (en) | 1991-09-06 | 1998-03-10 | The United States Of America As Represented By The Secretary Of Agriculture | Polypeptides useful in prevention of chlamydia infection |
| DE69313134T2 (de) | 1992-06-25 | 1998-02-26 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| AU669000B2 (en) | 1992-09-18 | 1996-05-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Synthetic peptide vaccine for chlamydia trachomatis |
| US5549978A (en) * | 1992-10-30 | 1996-08-27 | Kabushiki Kaisha Toshiba | Magnetoresistance effect element |
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| CN100365017C (zh) | 1994-09-20 | 2008-01-30 | 日立化成工业株式会社 | 肺炎衣原体抗原多肽 |
| GB9506863D0 (en) * | 1995-04-03 | 1995-05-24 | Smithkline Beecham Biolog | Vaccines |
| GB9626864D0 (en) | 1996-12-24 | 1997-02-12 | Smithkline Beecham Biolog | Vaccine |
| GB9516293D0 (en) | 1995-08-09 | 1995-10-11 | Immunova Ltee | Novel peptides and their use as vaccines |
| CN1223589A (zh) * | 1996-05-06 | 1999-07-21 | 美国拜尔公司 | 包含鹦鹉热衣原体的猫疫苗及其制备方法 |
| WO1998002546A2 (en) | 1996-07-12 | 1998-01-22 | University Of Manitoba | Dna immunization against chlamydia infection |
| US6464979B1 (en) | 1996-09-12 | 2002-10-15 | Aventis Pasteur Limited | Chlamydial vaccines and methods of preparation thereof |
| US7459524B1 (en) * | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| JP4249279B2 (ja) | 1997-10-22 | 2009-04-02 | デンカ生研株式会社 | クラミジア・トラコマティス主要外膜蛋白質及びその製造方法、並びにクラミジア・トラコマティスの抗体測定方法及び抗体測定試薬 |
| ATE480625T1 (de) * | 1997-11-21 | 2010-09-15 | Merck Serono Biodevelopment | Äusseres membranpolypeptid von chlamydia pneumoniae sowie fragmente davon und deren verwendung, insbesondere zur diagnose, prävention und behandlung einer infektion |
| KR20010032336A (ko) | 1997-11-21 | 2001-04-16 | 브랑디 빠스깔 | 클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| US7041490B1 (en) * | 1997-11-28 | 2006-05-09 | Serono Genetics Institute, S.A. | Chlamydia trachomatis polynucleotides and vectors, recombinant host cells, DNA chips or kits containing the same |
| KR100760221B1 (ko) * | 1997-11-28 | 2007-10-30 | 세로노 제네틱스 인스티튜트 에스.에이. | 클라미디아 트라코마티스 게놈 서열과 폴리펩티드, 이의단편 및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
| BR9909472A (pt) | 1998-04-07 | 2001-09-11 | Corixa Corp | Polipeptìdeo purificado, processo para prevenir tuberculose, e, composição farmacêutica |
| ES2284287T3 (es) * | 1998-10-16 | 2007-11-01 | Glaxosmithkline Biologicals S.A. | Sistemas adyuvantes y vacunas. |
| US6607730B1 (en) * | 1998-11-02 | 2003-08-19 | Aventis Pasteur Limited/Aventis Pasteur Limitee | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| EP1133572A4 (en) | 1998-11-12 | 2005-06-15 | Univ California | GENOME SEQUENCE OF CHLAMYDIA PNEUMONIAE |
| US20020061848A1 (en) * | 2000-07-20 | 2002-05-23 | Ajay Bhatia | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6166177A (en) * | 1998-12-08 | 2000-12-26 | Corixa Corporation | Compounds and methods for the treatment and diagnosis of chlamydial infection |
| US6555115B1 (en) * | 1998-12-08 | 2003-04-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6565856B1 (en) * | 1998-12-08 | 2003-05-20 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6448234B1 (en) * | 1998-12-08 | 2002-09-10 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US20080213264A1 (en) * | 1998-12-08 | 2008-09-04 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US6432916B1 (en) * | 1998-12-08 | 2002-08-13 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| CN100365120C (zh) * | 1998-12-08 | 2008-01-30 | 科里克萨有限公司 | 用于治疗及诊断衣原体感染的化合物和方法 |
| US6447779B1 (en) * | 1998-12-08 | 2002-09-10 | Corixa Corporation | Compounds for the diagnosis of Chlamydial infection |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| GB9902555D0 (en) | 1999-02-05 | 1999-03-24 | Neutec Pharma Plc | Medicament |
| EP2172214A3 (en) | 1999-03-12 | 2011-03-16 | Aventis Pasteur Limited | Chlamydia antigens and corresponding DNA fragments and uses thereof |
| WO2000066739A2 (en) | 1999-05-03 | 2000-11-09 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| US6811783B1 (en) | 1999-09-07 | 2004-11-02 | Aventis Pasteur Limited | Immunogenic compositions for protection against chlamydial infection |
| CA2385325C (en) | 1999-09-20 | 2012-04-10 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| CA2937907C (en) | 1999-09-28 | 2017-08-22 | Geneohm Sciences Canada Inc. | Nucleic acids, methods and kits for the detection of campylobacter |
| AU4503201A (en) * | 1999-10-14 | 2001-06-12 | University Of Utah Research Foundation | Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods |
| WO2001035992A1 (en) * | 1999-11-19 | 2001-05-25 | Michigan State University | Recombinant chlamydia vaccine |
| EP1240331B1 (en) | 1999-12-22 | 2010-04-07 | Aventis Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| US20010048927A1 (en) * | 2000-02-01 | 2001-12-06 | Richard Stephens | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by chlamydia |
| US6919187B2 (en) | 2000-04-21 | 2005-07-19 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| AU2001255596A1 (en) * | 2000-04-21 | 2001-11-07 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US20020146776A1 (en) | 2000-04-21 | 2002-10-10 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| EP1282718B1 (en) | 2000-05-08 | 2006-12-20 | Sanofi Pasteur Limited | Chlamydia antigens and corresponding dna fragments and uses thereof |
| JP2003536270A (ja) * | 2000-06-16 | 2003-12-02 | アプライド マテリアルズ インコーポレイテッド | 単一基板ウェット−ドライ一体型クラスター洗浄機 |
| ATE440861T1 (de) | 2000-07-03 | 2009-09-15 | Novartis Vaccines & Diagnostic | Immunisierung gegen chlamydia pneumoniae |
| WO2002008627A1 (de) * | 2000-07-20 | 2002-01-31 | Zf Friedrichshafen Ag | Elektromagnetisch betätigbare, schleifringlose einflächen-reibungskupplung |
| US7537772B1 (en) * | 2000-10-02 | 2009-05-26 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, gene sequence and the uses thereof |
| US7731980B2 (en) | 2000-10-02 | 2010-06-08 | Emergent Product Development Gaithersburg Inc. | Chlamydia PMP proteins, gene sequences and uses thereof |
| GB0103169D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| AU2002306849A1 (en) * | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| WO2002079244A2 (en) * | 2001-03-30 | 2002-10-10 | University Of Manitoba | Chlamydial protease-like activity factor responsible for degradation of host transcription factor |
| US20030199438A1 (en) * | 2001-04-09 | 2003-10-23 | Shaw Allan Christian | Method for identification of proteins from intracellular bacteria |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| ES2386386T3 (es) * | 2001-12-12 | 2012-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Inmunización contra Chlamydia trachomatis |
| US7105171B2 (en) * | 2002-03-07 | 2006-09-12 | The Regents Of The University Of California | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia |
| WO2005002619A2 (en) * | 2003-06-26 | 2005-01-13 | Chiron Corporation | Immunogenic compositions for chlamydia trachomatis |
| FR2869057B1 (fr) * | 2004-04-16 | 2006-06-02 | Piscines Desjoyaux Sa Sa | Dispositif pour la realisation d'un haut de chainage d'un escalier |
| JP5024830B2 (ja) | 2004-10-25 | 2012-09-12 | ステーテンズ セーラム インスティテュート | クラミジア・トラコマチス（Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓ）抗原のワクチンおよび診断への使用 |
| CN101184504A (zh) | 2005-03-31 | 2008-05-21 | 葛兰素史密丝克莱恩生物有限公司 | 针对衣原体感染的疫苗 |
| US8541007B2 (en) * | 2005-03-31 | 2013-09-24 | Glaxosmithkline Biologicals S.A. | Vaccines against chlamydial infection |
| AU2006259858A1 (en) * | 2005-05-12 | 2006-12-28 | Novartis Vaccines And Diagnostics S.R.L. | Immunogenic compositions for Chlamydia trachomatis |
| WO2007110700A2 (en) * | 2005-12-22 | 2007-10-04 | Novartis Vaccines And Diagnostics, Srl. | Chlamydial antigens |
| US9259463B2 (en) * | 2006-01-16 | 2016-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chlamydia vaccine |
| US20080124338A1 (en) * | 2006-09-22 | 2008-05-29 | The Scripps Research Institute | Methods for treatment of inflammatory disease and chlamydia infectious disease |
| CA2664236A1 (en) * | 2006-10-04 | 2008-04-10 | Glaxosmithkline Biologicals S.A. | Vaccines against chlamydial infection |
| US7892567B2 (en) * | 2007-10-01 | 2011-02-22 | Board Of Regents, The University Of Texas System | Methods and compositions for immunization against chlamydial infection and disease |
| US9068007B2 (en) * | 2008-10-09 | 2015-06-30 | Board Of Regents, The University Of Texas System | Methods and compositions for chlamydial antigens for diagnosis and treatment of chlamydial infection and disease |
| CA2781805A1 (en) * | 2008-12-17 | 2010-07-08 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| WO2010100632A2 (en) * | 2009-03-06 | 2010-09-10 | Novartis Ag | Chlamydia antigens |
| EP2544715A2 (en) * | 2010-03-09 | 2013-01-16 | Board Of Regents, University Of Texas System | Methods and compositions for chlamydial antigens for diagnosis and treatment of chlamydial infection and disease |
-
2001
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- 2001-07-20 WO PCT/US2001/023121 patent/WO2002008267A2/en not_active Ceased
- 2001-07-20 ES ES01959114T patent/ES2294018T3/es not_active Expired - Lifetime
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- 2001-07-20 RU RU2003104976/13A patent/RU2003104976A/ru not_active Application Discontinuation
- 2001-07-20 CZ CZ2003480A patent/CZ2003480A3/cs unknown
- 2001-07-20 CN CNB018148484A patent/CN100467600C/zh not_active Expired - Fee Related
- 2001-07-20 DK DK01959114T patent/DK1307564T3/da active
- 2001-07-20 EP EP01959114A patent/EP1307564B1/en not_active Expired - Lifetime
- 2001-07-20 AU AU2001280702A patent/AU2001280702B8/en not_active Ceased
- 2001-07-20 AU AU8070201A patent/AU8070201A/xx active Pending
- 2001-07-20 RU RU2006120003/10A patent/RU2410394C2/ru not_active IP Right Cessation
- 2001-07-20 IL IL15390401A patent/IL153904A0/xx unknown
- 2001-07-20 PL PL365951A patent/PL209107B1/pl not_active IP Right Cessation
- 2001-07-20 DE DE60130468T patent/DE60130468T2/de not_active Expired - Lifetime
- 2001-07-20 MX MXPA03000564A patent/MXPA03000564A/es active IP Right Grant
- 2001-07-20 BR BR0112602-4A patent/BR0112602A/pt not_active Application Discontinuation
- 2001-07-20 HU HU0400477A patent/HUP0400477A3/hu unknown
- 2001-07-20 CA CA002418282A patent/CA2418282A1/en not_active Abandoned
- 2001-07-20 JP JP2002514171A patent/JP2004513622A/ja active Pending
- 2001-07-20 NZ NZ523628A patent/NZ523628A/en not_active IP Right Cessation
- 2001-07-20 KR KR10-2003-7000885A patent/KR20030016423A/ko not_active Ceased
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2003
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- 2003-01-17 NO NO20030252A patent/NO20030252L/no not_active Application Discontinuation
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2004
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2007
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2011
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