CN1489628A

CN1489628A - 用于治疗和诊断衣原体感染的化合物和方法

Info

Publication number: CN1489628A
Application number: CNA018148484A
Authority: CN
Inventors: Sp; S·P·福莱; W; Y·A·W·斯凯克; P·普罗伯斯特; A·巴蒂亚
Original assignee: Corixa Corp
Current assignee: Corixa Corp
Priority date: 2000-07-20
Filing date: 2001-07-20
Publication date: 2004-04-14
Anticipated expiration: 2021-07-20
Also published as: ES2294018T3; US8052975B2; US20110142872A1; HK1067381A1; RU2006120003A; KR20030016423A; RU2003104976A; NZ541013A; HUP0400477A3; IL153904A; HUP0400477A2; WO2002008267A3; ZA200300719B; US20080299142A1; NZ549873A; PL209107B1; JP2004513622A; US20120114684A1; US20080317772A1; DK1307564T3

Abstract

本发明公开了用于诊断和治疗衣原体感染的化合物和方法。所提供的化合物包括含有衣原体抗原的至少一个抗原性部分的多肽和编码该多肽的DNA序列。本发明还提供包含该多肽或DNA序列的药物组合物和疫苗，以及抗该多肽的抗体。含有该多肽或DNA序列的诊断试剂盒和适宜的检测试剂可以用于检测患者和生物学样品中的衣原体感染。

Description

用于治疗和诊断衣原体感染的化合物和方法

技术领域

本发明一般涉及衣原体感染的检测和治疗。具体地，本发明涉及包含衣原体抗原的多肽和这类多肽在衣原体感染的血清学诊断和治疗中的用途。

发明背景

衣原体(Chlamydiae)是对许多重要的人和动物感染负有责任的细胞内细菌病原体。沙眼衣原体(Chlamydia trachomatis)是性传播疾病最常见的原因之一，能引起盆腔炎(pelvic inflammatorydisease，PID)，导致输卵管阻塞和不育。沙眼衣原体也可能引起男性不育。在1990年，美国治疗PID的费用估计为40亿美元。由于沙眼衣原体感染眼睛引起的沙眼在全世界是可预防的失明的主要原因。肺炎衣原体(Chlamydia pneumonia)是人急性呼吸道感染的主要原因，据信还在动脉粥样硬化(尤其是冠心病)的致病中起某种作用。已证明具有高滴度肺炎衣原体抗体的个体患冠心病的可能性是血清阴性个体的至少2倍。因此，衣原体感染是美国和全世界的重要健康问题。

衣原体感染常常是无症状的。例如，到妇女寻求PID的医学治疗时，可能已经发生了不可逆转的损伤，导致不育。因此本领域需要用于预防和治疗衣原体感染的改良疫苗和药物组合物。本发明满足了这种需要，并进一步提供其它相关优点。

发明概述

本发明提供用于诊断和治疗衣原体感染的组合物和方法。一方面，本发明提供包含衣原体抗原(或这种抗原的变体)的免疫原性部分的多肽。某些部分和其它变体是免疫原性的，以致该变体与抗原特异性抗血清反应的能力基本上没有减少。在某些实施方案中，该多肽包含选自如下序列的多核苷酸序列所编码的氨基酸序列：(a)SEQ ID NO：358-361、366-385、406-430、455-489、516-517、523-559、和582-596的序列；(b)所述序列的互补序列；和(c)在中等严紧至高严紧条件下与(a)或(b)的序列杂交的序列。在具体实施方案中，本发明的多肽含有包括从SEQ ID NO：362-365、386-405、431-454、490-515、518-522、560-581、和597-599所示序列选择的氨基酸序列的衣原体蛋白质或其变体的至少一部分。

本发明进一步提供编码上述多肽的多核苷酸或其部分(如编码衣原体蛋白质的至少15个氨基酸残基的部分)、含有这种多核苷酸的表达载体和转化或转染了这种表达载体的宿主细胞。

在相关方面，还提供编码上述多肽的多核苷酸序列、含有这些多核苷酸序列之一个或多个的重组表达载体和转化或转染了这种表达载体的宿主细胞。

在另一方面，本发明提供含有本发明多肽，或作为替代方案，含有本发明多肽和已知衣原体抗原的融合蛋白，以及编码这种融合蛋白的多核苷酸，与生理可接受载体或免疫刺激剂联合用作其药物组合物和疫苗。

本发明进一步提供药物组合物，其包含：(a)特异结合衣原体蛋白质的多克隆或单克隆抗体，或其抗原结合片断；和(b)生理可接受载体。在其它方面，本发明提供药物组合物，其含有这里公开的一种或多种衣原体多肽，例如SEQ ID NO：362-365、386-405、431-454、490-515、518-522、560-581、和597-599所示的多肽，或编码这种多肽的多核苷酸分子，如SEQ ID NO：358-361、366-385、406-430、455-489、516-517、523-559、和582-596所示的多核苷酸，和生理可接受载体。本发明还提供用于预防或治疗的、包含这里公开的一种或多种多肽和这里所定义的免疫刺激剂的疫苗，以及含有一种或多种编码这种多肽的多核苷酸序列和免疫刺激剂的疫苗。

在另一方面，本发明提供诱导患者保护性免疫的方法，包括给患者施用有效量的一种或多种上述药物组合物或疫苗。

在另一方面，本发明提供治疗患者衣原体感染的方法，该方法包括：从患者获得外周血单个核细胞(PBMC)，将PBMC和本发明的多肽(或编码这种多肽的多核苷酸)孵育以提供孵育过的T细胞，和将该孵育过的T细胞施用给该患者。本发明还提供治疗衣原体感染的方法，包括：将抗原呈递细胞与本发明的多肽(或编码这种多肽的多核苷酸)孵育以提供孵育过的抗原呈递细胞，和将该孵育过的抗原呈递细胞施用给该患者。增殖的细胞可以，但不必须，在施用给患者前克隆化。在某些实施方案中，抗原呈递细胞选自树突细胞、巨噬细胞、单核细胞、B细胞和成纤维细胞。还提供用于治疗衣原体感染的组合物，其包含已与本发明的多肽或多核苷酸孵育过的T细胞或抗原呈递细胞。在相关方面，提供疫苗，其包含：(a)表达上述多肽的抗原呈递细胞和(b)免疫刺激剂。

在其它方面，本发明进一步提供从生物样品中除去衣原体感染的细胞的方法，包括将生物样品和特异地与衣原体蛋白质反应的T细胞接触，其中该接触步骤在足以允许从该样品中除去表达该蛋白质的细胞的条件和时间下实施。

在相关方面，本发明提供抑制患者衣原体感染发展的方法，包括给患者施用如上处理过的生物样品。在另一方面，本发明提供检测患者衣原体感染的方法和诊断试剂盒。在一个实施方案中，该方法包括：(a)将生物样品与这里公开的至少一种多肽或融合蛋白接触；和(b)在该样品中检测与该多肽或融合蛋白结合的结合剂的存在，由此检测该生物样品中的衣原体感染。适当的生物样品包括全血、痰、血清、血浆、唾液、脑脊液和尿液。在一个实施方案中，诊断试剂盒包含这里公开的一种或多种多肽或融合蛋白以及检测试剂。在另一个实施方案中，诊断试剂盒包含结合本发明多肽的单克隆抗体或多克隆抗体。

本发明还提供检测衣原体感染的方法，包括：(a)从患者获得生物学样品；(b)在聚合酶链式反应中将该样品与至少两个寡核苷酸引物接触，该寡核苷酸引物中的至少一个是这里公开的多核苷酸序列所特异的；和(c)检测该样品中在存在所述寡核苷酸引物时扩增的多核苷酸序列。在一个实施方案中，该寡核苷酸引物含有本文公开的多核苷酸序列或与之杂交的序列的至少约10个连续核苷酸。

在其它方面，本发明提供检测患者衣原体感染的方法，包括：(a)从该患者获得生物学样品；(b)将该样品与这里公开的多核苷酸序列特异的寡核苷酸探针接触；和(c)检测该样品中与该寡核苷酸探针杂交的多核苷酸序列。在一个实施方案中，寡核苷酸探针含有这里公开的多核苷酸序列或与之杂交的序列的至少约15个连续核苷酸。

参考以下详细说明，本发明的这些和其它方面将是明显的。这里公开的所有参考文献均完整地引入本文作为参考，就象是每一篇文献单独引入一样。

序列标识

SEQ ID NO：1是沙眼衣原体克隆1-B1-66的测定的DNA序列。

SEQ ID NO：2是沙眼衣原体克隆4-D7-28的测定的DNA序列。

SEQ ID NO：3是沙眼衣原体克隆3-G3-10的测定的DNA序列。

SEQ ID NO：4是沙眼衣原体克隆10-C10-31的测定的DNA序列。

SEQ ID NO：5是1-B1-66的预测的氨基酸序列。

SEQ ID NO：6是4-D7-28的预测的氨基酸序列。

SEQ ID NO：7是3-G3-10的第一个预测的氨基酸序列。

SEQ ID NO：8是3-G3-10的第二个预测的氨基酸序列。

SEQ ID NO：9是3-G3-10的第三个预测的氨基酸序列。

SEQ ID NO：10是3-G3-10的第四个预测的氨基酸序列。

SEQ ID NO：11是3-G3-10的第五个预测的氨基酸序列。

SEQ ID NO：12是10-C10-31的预测的氨基酸序列。

SEQ ID NO：13是合成肽1-B1-66/48-67的氨基酸序列。

SEQ ID NO：14是合成肽1-B1-66/58-77的氨基酸序列。

SEQ ID NO：15是沙眼衣原体血清变型LGV II克隆2C7-8的测定的DNA序列。

SEQ ID NO：16是2C7-8作图所在沙眼衣原体血清变型D基因组区域的推测可读框的DNA序列。

SEQ ID NO：17是SEQ ID NO：16 DNA序列所编码的预测氨基酸序列。

SEQ ID NO：18是合成肽CtC7.8-12的氨基酸序列。

SEQ ID NO：19是合成肽CtC7.8-13的氨基酸序列。

SEQ ID NO：20是沙眼衣原体血清变型D的第二个推测的可读框编码的预测氨基酸序列。

SEQ ID NO：21是沙眼衣原体LGV II克隆4C9-18的测定的DNA序列。

SEQ ID NO：22是与沙眼衣原体LGV II硫辛酰胺脱氢酶同源的测定的DNA序列。

SEQ ID NO：23是与沙眼衣原体LGV II假拟蛋白同源的测定的DNA序列。

SEQ ID NO：24是与沙眼衣原体LGV II泛醌甲基转移酶同源的测定的DNA序列。

SEQ ID NO：25是沙眼衣原体LGV II克隆4C9-18#2 BL21 pLysS测定的DNA序列。

SEQ ID NO：26是沙眼衣原体LGV II的4C9-18#2的预测的氨基酸序列。

SEQ ID NO：27是肺炎衣原体TWAR株的Cp-SWIB的测定的DNA序列。

SEQ ID NO：28是肺炎衣原体TWAR株的Cp-SWIB的预测的氨基酸序列。

SEQ ID NO：29是肺炎衣原体TWAR株的Cp-S13(CT509)的测定的DNA序列。

SEQ ID NO：30是肺炎衣原体TWAR株的Cp-S13的预测的氨基酸序列。

SEQ ID NO：31是CtC7.8-12和CtC7.8-13的10mer(聚体)共有序列肽的氨基酸序列。

SEQ ID NO：32是沙眼衣原体LGV II的克隆2C7-8的预测的氨基酸序列。

SEQ ID NO：33是与沙眼衣原体血清变型D基因组第597304-597145位核苷酸相应的DNA序列(NCBI，BLASTN search)，其与克隆2C7-8有同源性。

SEQ ID NO：34是SEQ ID NO：33的序列所编码的预测氨基酸序列。

SEQ ID NO：35是肺炎衣原体的C.p.SWIB Nde(5’引物)的DNA序列。

SEQ ID NO：36是肺炎衣原体的C.p.SWIB EcoRI(3’引物)的DNA序列。

SEQ ID NO：37是肺炎衣原体的C.p.S13 Nde(5’引物)的DNA序列。

SEQ ID NO：38是肺炎衣原体的C.p.S13 EcoRI(3’引物)的DNA序列。

SEQ ID NO：39是沙眼衣原体LGV II的CtSwib 52-67肽的氨基酸序列。

SEQ ID NO：40是肺炎衣原体的CpSwib 53-68肽的氨基酸序列。

SEQ ID NO：41是SWI域的HuSwib 288-302肽的氨基酸序列。

SEQ ID NO：42是沙眼衣原体拓扑异构酶-SWIB融合物的CtSWI-T822-837肽的氨基酸序列。

SEQ ID NO：43是肺炎衣原体拓扑异构酶-SWIB融合物的CpSWI-T828-842肽的氨基酸序列。

SEQ ID NO：44是沙眼衣原体LGV II克隆19783.3，jen.seq(1＞509)CTL2#11-3’的第一个测定的DNA序列，代表3’端。

SEQ ID NO：45是沙眼衣原体LGV II克隆19783.4，jen.seq(1＞481)CTL2#11-5’的第二个测定的DNA序列，代表5’端。

SEQ ID NO：46是沙眼衣原体LGV II克隆19784CTL2-12consensus.seq(1＞427)CTL2#12的测定的DNA序列。

SEQ ID NO：47是沙眼衣原体LGV II 克隆19785.4，jen.seq(1＞600)CTL2#16-5’的测定的DNA序列，代表5’端。

SEQ ID NO：48是沙眼衣原体LGV II克隆19786.3，jen.seq(1＞600)CTL2#18-3’的第一个测定的DNA序列，代表3’端。

SEQ ID NO：49是沙眼衣原体LGV II 克隆19786.4，jen.seq(1＞600)CTL2#18-5’的第二个测定的DNA序列，代表5’端。

SEQ ID NO：50是沙眼衣原体LGV II克隆19788CTL2-21consensus.seq(1＞406)CTL2#21的测定的DNA序列。

SEQ ID NO：51是沙眼衣原体LGV II克隆19790CTL2-23consensus.seq(1＞602)CTL2#23的测定的DNA序列。

SEQ ID NO：52是沙眼衣原体LGV II克隆19791CTL2-24consensus.seq(1＞145)CTL2#24的测定的DNA序列。

SEQ ID NO：53是沙眼衣原体LGV II克隆CTL2#4的测定的DNA序列。

SEQ ID NO：54是沙眼衣原体LGV II克隆CTL2#8b的测定的DNA序列。

SEQ ID NO：55是沙眼衣原体LGV II克隆15-G1-89的测定的DNA序列，与硫辛酰胺脱氢酶基因CT557有同源性。

SEQ ID NO：56是沙眼衣原体LGV II克隆14-H1-4的测定的DNA序列，与硫醇特异性抗氧化剂基因CT603有同源性。

SEQ ID NO：57是沙眼衣原体LGV II克隆12-G3-83的测定的DNA序列，与假拟蛋白CT622有同源性。

SEQ ID NO：58是沙眼衣原体LGV II克隆12-B3-95的测定的DNA序列，与硫辛酰胺脱氢酶基因CT557有同源性。

SEQ ID NO：59是沙眼衣原体LGV II克隆11-H4-28的测定的DNA序列，与dnaK基因CT396有同源性。

SEQ ID NO：60是沙眼衣原体LGV II克隆11-H3-68的测定的DNA序列，与PGP6-D毒力蛋白和LI核糖体基因CT318有部分同源性。

SEQ ID NO：61是沙眼衣原体LGV II克隆11-G1-34的测定的DNA序列，与苹果酸脱氢酶基因CT376和糖元水解酶基因CT042有部分同源性。

SEQ ID NO：62是沙眼衣原体LGV II克隆11-G10-46的测定的DNA序列，与假拟蛋白CT610有同源性。

SEQ ID NO：63是沙眼衣原体LGV II克隆11-C12-91的测定的DNA序列，与OMP2基因CT443有同源性。

SEQ ID NO：64是沙眼衣原体LGV II克隆11-A3-93的测定的DNA序列，与HAD超家族基因CT103有同源性。

SEQ ID NO：65是沙眼衣原体LGV II克隆14-H1-4的测定的氨基酸序列，与硫醇特异性抗氧化剂基因CT603有同源性。

SEQ ID NO：66是沙眼衣原体LGV II克隆CtL2#9的测定的DNA序列。

SEQ ID NO：67是沙眼衣原体LGV II克隆CtL2#7的测定的DNA序列。

SEQ ID NO：68是沙眼衣原体LGV II克隆CtL2#6的测定的DNA序列。

SEQ ID NO：69是沙眼衣原体LGV II克隆CtL2#5的测定的DNA序列。

SEQ ID NO：70是沙眼衣原体LGV II克隆CtL2#2的测定的DNA序列。

SEQ ID NO：71是沙眼衣原体LGV II克隆CtL2#1的测定的DNA序列。

SEQ ID NO：72是沙眼衣原体LGV II克隆23509.2CtL2#3-5’的第一个测定的DNA序列，代表5’端。

SEQ ID NO：73是沙眼衣原体LGV II克隆23509.1CtL2#3-3’的第二个测定的DNA序列，代表3’端。

SEQ ID NO：74是沙眼衣原体LGV II克隆22121.2CtL2#10-5’的第一个测定的DNA序列，代表5’端。

SEQ ID NO：75是沙眼衣原体LGV II克隆22121.1CtL2#10-3’的第二个测定的DNA序列，代表3’端。

SEQ ID NO：76是沙眼衣原体LGV II克隆19787.6CtL2#19-5’的测定的DNA序列，代表5’端。

SEQ ID NO：77是肺炎衣原体LGV II克隆CpS13-His的测定的DNA序列。

SEQ ID NO：78是肺炎衣原体LGV II克隆Cp_SWIB-His的测定的DNA序列。

SEQ ID NO：79是沙眼衣原体LGV II克隆23-G7-68的测定的DNA序列，与L11，L10和L1核糖体蛋白有部分同源性。

SEQ ID NO：80是沙眼衣原体LGV II克隆22-F8-91的测定的DNA序列，与pmpC基因有同源性。

SEQ ID NO：81是沙眼衣原体LGV II克隆21-E8-95的测定的DNA序列，与CT610-CT613基因有同源性。

SEQ ID NO：82是沙眼衣原体LGV II克隆19-F12-57的测定的DNA序列，与CT858和recA基因有同源性。

SEQ ID NO：83是沙眼衣原体LGV II克隆19-F12-53的测定的DNA序列，与编码谷氨酰tRNA合成酶的CT445基因有同源性。

SEQ ID NO：84是沙眼衣原体LGV II克隆19-A5-54的测定的DNA序列，与隐蔽性质粒基因有同源性。

SEQ ID NO：85是沙眼衣原体LGV II克隆17-E11-72的测定的DNA序列，与OppC-2和pmpD基因有部分同源性。

SEQ ID NO：86是沙眼衣原体LGV II克隆17-C1-77的测定的DNA序列，与CT857和CT858可读框有部分同源性。

SEQ ID NO：87是沙眼衣原体LGV II克隆15-H2-76的测定的DNA序列，与pmpD和SycE基因及CT089 ORF(可读框)有部分同源性。

SEQ ID NO：88是沙眼衣原体LGV II克隆15-A3-26的测定的DNA序列，与CT858 ORF有同源性。

SEQ ID NO：89是肺炎衣原体克隆Cp_SWIB-His的测定的氨基酸序列。

SEQ ID NO：90是沙眼衣原体LGV II克隆CtL2_LPDA_FL的测定的氨基酸序列。

SEQ ID NO：91是肺炎衣原体克隆CpS13-His的测定的氨基酸序列。

SEQ ID NO：92是沙眼衣原体LGV II克隆CtL2_TSA_FL的测定的氨基酸序列。

SEQ ID NO：93是沙眼衣原体LGV II的Ct-Swib 43-61肽的氨基酸序列。

SEQ ID NO：94是沙眼衣原体LGV II的Ct-Swib 48-67肽的氨基酸序列。

SEQ ID NO：95是沙眼衣原体LGV II的Ct-Swib 52-71肽的氨基酸序列。

SEQ ID NO：96是沙眼衣原体LGV II的Ct-Swib 58-77肽的氨基酸序列。

SEQ ID NO：97是沙眼衣原体LGV II的Ct-Swib 63-82肽的氨基酸序列。

SEQ ID NO：98是沙眼衣原体LGV II的Ct-Swib 51-66肽的氨基酸序列。

SEQ ID NO：99是肺炎衣原体的Cp-Swib 52-67肽的氨基酸序列。

SEQ ID NO：100是肺炎衣原体的Cp-Swib 37-51肽的氨基酸序列。

SEQ ID NO：101是肺炎衣原体的Cp-Swib 32-51肽的氨基酸序列。

SEQ ID NO：102是肺炎衣原体的Cp-Swib 37-56肽的氨基酸序列。

SEQ ID NO：103是沙眼衣原体的Ct-Swib 36-50肽的氨基酸序列。

SEQ ID NO：104是沙眼衣原体的Ct-S13 46-65肽的氨基酸序列。

SEQ ID NO：105是沙眼衣原体的Ct-S13 60-80肽的氨基酸序列。

SEQ ID NO：106是沙眼衣原体的Ct-S13 1-20肽的氨基酸序列。

SEQ ID NO：107是沙眼衣原体的Ct-S13 46-65肽的氨基酸序列。

SEQ ID NO：108是沙眼衣原体的Ct-S13 56-75肽的氨基酸序列。

SEQ ID NO：109是肺炎衣原体的Cp-S13 56-75肽的氨基酸序列。

SEQ ID NO：110是沙眼衣原体LGV II克隆21-G12-60的测定的DNA序列，含有假拟蛋白CT875，CT229和CT228的部分可读框。

SEQ ID NO：111是沙眼衣原体LGV II克隆22-B3-53的测定的DNA序列，与GroEL的CT110 ORF有同源性。

SEQ ID NO：112是沙眼衣原体LGV II克隆22-A1-49的测定的DNA序列，与CT660和CT659 ORFs有部分同源性。

SEQ ID NO：113是沙眼衣原体LGV II克隆17-E2-9的测定的DNA序列，与CT611和CT610 ORFs有部分同源性。

SEQ ID NO：114是沙眼衣原体LGV II克隆17-C10-31的测定的DNA序列，与CT858 ORF有部分同源性。

SEQ ID NO：115是沙眼衣原体LGV II克隆21-C7-8的测定的DNA序列，与dnaK样基因(dnaK-like gene)有同源性。

SEQ ID NO：116是沙眼衣原体LGV II克隆20-G3-45的测定的DNA序列，含有pmpB基因CT413的一部分。

SEQ ID NO：117是沙眼衣原体LGV II克隆18-C5-2的测定的DNA序列，与S1核糖体蛋白ORF有同源性。

SEQ ID NO：118是沙眼衣原体LGV II克隆17-C5-19的测定的DNA序列，含有CT431和CT430 ORFs的一部分。

SEQ ID NO：119是沙眼衣原体LGV II克隆16-D4-22的测定的DNA序列，含有用于在哺乳动物细胞中生长的质粒的ORF3和ORF4的部分序列。

SEQ ID NO：120是沙眼衣原体血清变型LGV II Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：121是沙眼衣原体血清变型LGV II Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：122是沙眼衣原体血清变型E Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：123是沙眼衣原体血清变型E Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：124是沙眼衣原体血清变型1A Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：125是沙眼衣原体血清变型1A Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：126是沙眼衣原体血清变型G Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：127是沙眼衣原体血清变型G Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：128是沙眼衣原体血清变型F1 NII Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：129是沙眼衣原体血清变型F1 NII Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：130是沙眼衣原体血清变型L1 Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：131是沙眼衣原体血清变型L1 Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：132是沙眼衣原体血清变型L3 Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：133是沙眼衣原体血清变型L3 Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：134是沙眼衣原体血清变型Ba Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：135是沙眼衣原体血清变型Ba Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：136是沙眼衣原体血清变型MOPN Cap1基因CT529的测定的全长DNA序列。

SEQ ID NO：137是沙眼衣原体血清变型MOPN Cap1基因CT529的预测的全长氨基酸序列。

SEQ ID NO：138是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#124-139的测定的氨基酸序列。

SEQ ID NO：139是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#132-147的测定的氨基酸序列。

SEQ ID NO：140是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#138-155的测定的氨基酸序列。

SEQ ID NO：141是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#146-163的测定的氨基酸序列。

SEQ ID NO：142是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#154-171的测定的氨基酸序列。

SEQ ID NO：143是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#162-178的测定的氨基酸序列。

SEQ ID NO：144是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#138-147的测定的氨基酸序列。

SEQ ID NO：145是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#139-147的测定的氨基酸序列。

SEQ ID NO：146是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#140-147的测定的氨基酸序列。

SEQ ID NO：147是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#138-146的测定的氨基酸序列。

SEQ ID NO：148是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#138-145的测定的氨基酸序列。

SEQ ID NO：149是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽#F140-＞I的测定的氨基酸序列。

SEQ ID NO：150是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽##S139＞Ga的测定的氨基酸序列。

SEQ ID NO：151是沙眼衣原体血清变型L2的Cap1 CT529 ORF肽##S139＞Gb的测定的氨基酸序列。

SEQ ID NO：152是沙眼衣原体血清变型L2的216aa(氨基酸)ORF的肽#2 C7.8-6的测定的氨基酸序列。

SEQ ID NO：153是沙眼衣原体血清变型L2的216aa ORF的肽#2 C7.8-7的测定的氨基酸序列。

SEQ ID NO：154是沙眼衣原体血清变型L2的216aa ORF的肽#2C7.8-8的测定的氨基酸序列。

SEQ ID NO：155是沙眼衣原体血清变型L2的216aa ORF的肽#2 C7.8-9的测定的氨基酸序列。

SEQ ID NO：156是沙眼衣原体血清变型L2的216aa ORF的肽#2 C7.8-10的测定的氨基酸序列。

SEQ ID NO：157是沙眼衣原体血清变型L2克隆2C7.8内216aaORF的53个氨基酸残基肽的测定的氨基酸序列。

SEQ ID NO：158是沙眼衣原体血清变型L2克隆2C7.8内CT529ORF的52个氨基酸残基肽的测定的氨基酸序列。

SEQ ID NO：159是用于克隆全长CT529血清变型L2的5’(正向)引物的测定的DNA序列。

SEQ ID NO：160是用于克隆全长CT529清变型L2的5’(反向)引物的测定的DNA序列。

SEQ ID NO：161是用于克隆除L2和MOPN以外的全长CT529血清变型的5’(正向)引物的测定的DNA序列。

SEQ ID NO：162是用于克隆除L2和MOPN以外的全长CT529清变型的5’(反向)引物的测定的DNA序列。

SEQ ID NO：163是用于克隆全长CT529清变型MOPN的5’(正向)引物的测定的DNA序列。

SEQ ID NO：164是用于克隆全长CT529血清变型MOPN的5’(反向)引物的测定的DNA序列。

SEQ ID NO：165是pBIB-KS的5’(正向)引物的测定的DNA序列。

SEQ ID NO：166是pBIB-KS的5’(反向)引物的测定的DNA序列。

SEQ ID NO：167是血清变型L2的9-mer表位肽Cap1#139-147的测定的氨基酸序列。

SEQ ID NO：168是血清变型D的9-mer表位肽Cap1#139-147的测定的氨基酸序列。

SEQ ID NO：169是沙眼衣原体pmpI(CT874)基因的测定的全长DNA序列。

SEQ ID NO：170是沙眼衣原体pmpG基因的测定的全长DNA序列。

SEQ ID NO：171是沙眼衣原体pmpE基因的测定的全长DNA序列。

SEQ ID NO：172是沙眼衣原体pmpD基因的测定的全长DNA序列。

SEQ ID NO：173是沙眼衣原体pmpC基因的测定的全长DNA序列。

SEQ ID NO：174是沙眼衣原体pmpB基因的测定的全长DNA序列。

SEQ ID NO：175是沙眼衣原体pmpI基因的预测的全长氨基酸序列。

SEQ ID NO：176是沙眼衣原体pmpG基因的预测的全长氨基酸序列。

SEQ ID NO：177是沙眼衣原体pmpE基因的预测的全长氨基酸序列。

SEQ ID NO：178是沙眼衣原体pmpD基因的预测的全长氨基酸序列。

SEQ ID NO：179是沙眼衣原体pmpC基因的预测的全长氨基酸序列。

SEQ ID NO：180是沙眼衣原体pmpB基因的预测的全长氨基酸序列。

SEQ ID NO：181是沙眼衣原体pmpI基因的测定的DNA序列减去信号序列。

SEQ ID NO：182是沙眼衣原体pmpG基因的后来测定的全长DNA序列。

SEQ ID NO：183是沙眼衣原体pmpE基因的测定的DNA序列减去信号序列。

SEQ ID NO：184是沙眼衣原体pmpD基因第一个测定的DNA序列，代表羧基端。

SEQ ID NO：185是沙眼衣原体pmpD基因第二个测定的DNA序列，代表氨基端减去信号序列。

SEQ ID NO：186是沙眼衣原体pmpC基因第一个测定的DNA序列，代表羧基端。

SEQ ID NO：187是沙眼衣原体pmpC基因第二个测定的DNA序列，代表氨基端减去信号序列。

SEQ ID NO：188是测定的DNA序列，代表肺炎衣原体血清变型MOMPS pmp基因与Ra12处于融合分子中。

SEQ ID NO：189是沙眼衣原体pmpI基因的预测的氨基酸序列减去信号序列。

SEQ ID NO：190是沙眼衣原体pmpG基因的后来预测的氨基酸序列。

SEQ ID NO：191是沙眼衣原体pmpE基因的预测的氨基酸序列减去信号序列。

SEQ ID NO：192是沙眼衣原体pmpD基因第一个预测的氨基酸序列，代表羧基端。

SEQ ID NO：193是沙眼衣原体pmpD基因第二个预测的氨基酸序列，代表氨基端减去信号序列。

SEQ ID NO：194是沙眼衣原体pmpC基因第一个预测的氨基酸序列，代表羧基端。

SEQ ID NO：195是沙眼衣原体pmpC基因第二个预测的氨基酸序列，代表氨基端。

SEQ ID NO：196是预测的氨基酸序列，代表肺炎衣原体血清变型MOMPS pmp基因与Ra12处于融合分子中。

SEQ ID NO：197是用于在SKB疫苗载体中克隆沙眼衣原体pmpC基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：198是用于在SKB疫苗载体中克隆沙眼衣原体pmpC基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：199是用于在SKB疫苗载体中克隆沙眼衣原体pmpC基因的插入序列的测定的DNA序列。

SEQ ID NO：200是用于在SKB疫苗载体中克隆沙眼衣原体pmpD基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：201是用于在SKB疫苗载体中克隆沙眼衣原体pmpD基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：202是用于在SKB疫苗载体中克隆沙眼衣原体pmpD基因的插入序列的测定的DNA序列。

SEQ ID NO：203是用于在SKB疫苗载体中克隆沙眼衣原体pmpE基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：204是用于在SKB疫苗载体中克隆沙眼衣原体pmpe基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：205是用于在SKB疫苗载体中克隆沙眼衣原体pmpG基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：206是用于在SKB疫苗载体中克隆沙眼衣原体pmpG基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：207是用于在pET17b载体中克隆沙眼衣原体pmpC基因的氨基端部分的5’oligo引物的测定的DNA序列。

SEQ ID NO：208是用于在pET17b载体中克隆沙眼衣原体pmpC基因的氨基端部分的3’oligo引物的测定的DNA序列。

SEQ ID NO：209是用于在pET17b载体中克隆沙眼衣原体pmpC基因的羧基端部分的5’oligo引物的测定的DNA序列。

SEQ ID NO：210是用于在pET17b载体中克隆沙眼衣原体pmpC基因的羧基端部分的3’oligo引物的测定的DNA序列。

SEQ ID NO：211是用于在pET17b载体中克隆沙眼衣原体pmpD基因的氨基端部分的5’oligo引物的测定的DNA序列。

SEQ ID NO：212是用于在pET17b载体中克隆沙眼衣原体pmpD基因的氨基端部分的3’oligo引物的测定的DNA序列。

SEQ ID NO：213是用于在pET17b载体中克隆沙眼衣原体pmpD基因的羧基端部分的5’oligo引物的测定的DNA序列。

SEQ ID NO：214是用于在pET17b载体中克隆沙眼衣原体pmpD基因的羧基端部分的3’oligo引物的测定的DNA序列。

SEQ ID NO：215是用于在pET17b载体中克隆沙眼衣原体pmpE基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：216是用于在pET17b载体中克隆沙眼衣原体pmpE基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：217是用于在pET17b载体中克隆沙眼衣原体pmpE基因的插入序列的测定的DNA序列。

SEQ ID NO：218是用于在pET17b载体中克隆沙眼衣原体pmpE基因的插入序列的氨基酸序列。

SEQ ID NO：219是用于在pET17b载体中克隆沙眼衣原体pmpG基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：220是用于在pET17b载体中克隆沙眼衣原体pmpG基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：221是用于在pET17b载体中克隆沙眼衣原体pmpG基因的插入序列的氨基酸序列。

SEQ ID NO：222是用于在pET17b载体中克隆沙眼衣原体pmpI基因的5’oligo引物的测定的DNA序列。

SEQ ID NO：223是用于在pET17b载体中克隆沙眼衣原体pmpI基因的3’oligo引物的测定的DNA序列。

SEQ ID NO：224是肺炎衣原体Swib肽1-20的测定的氨基酸序列。

SEQ ID NO：225是肺炎衣原体Swib肽6-25的测定的氨基酸序列。

SEQ ID NO：226是肺炎衣原体Swib肽12-31的测定的氨基酸序列。

SEQ ID NO：227是肺炎衣原体Swib肽17-36的测定的氨基酸序列。

SEQ ID NO：228是肺炎衣原体Swib肽22-41的测定的氨基酸序列。

SEQ ID NO：229是肺炎衣原体Swib肽27-46的测定的氨基酸序列。

SEQ ID NO：230是肺炎衣原体Swib肽42-61的测定的氨基酸序列。

SEQ ID NO：231是肺炎衣原体Swib肽46-65的测定的氨基酸序列。

SEQ ID NO：232是肺炎衣原体Swib肽51-70的测定的氨基酸序列。

SEQ ID NO：233是肺炎衣原体Swib肽56-75的测定的氨基酸序列。

SEQ ID NO：234是肺炎衣原体Swib肽61-80的测定的氨基酸序列。

SEQ ID NO：235是肺炎衣原体Swib肽66-87的测定的氨基酸序列。

SEQ ID NO：236是沙眼衣原体OMCB肽103-122的测定的氨基酸序列。

SEQ ID NO：237是沙眼衣原体OMCB肽108-127的测定的氨基酸序列。

SEQ ID NO：238是沙眼衣原体OMCB肽113-132的测定的氨基酸序列。

SEQ ID NO：239是沙眼衣原体OMCB肽118-137的测定的氨基酸序列。

SEQ ID NO：240是沙眼衣原体OMCB肽123-143的测定的氨基酸序列。

SEQ ID NO：241是沙眼衣原体OMCB肽128-147的测定的氨基酸序列。

SEQ ID NO：242是沙眼衣原体OMCB肽133-152的测定的氨基酸序列。

SEQ ID NO：243是沙眼衣原体OMCB肽137-156的测定的氨基酸序列。

SEQ ID NO：244是沙眼衣原体OMCB肽142-161的测定的氨基酸序列。

SEQ ID NO：245是沙眼衣原体OMCB肽147-166的测定的氨基酸序列。

SEQ ID NO：246是沙眼衣原体OMCB肽152-171的测定的氨基酸序列。

SEQ ID NO：247是沙眼衣原体OMCB肽157-176的测定的氨基酸序列。

SEQ ID NO：248是沙眼衣原体OMCB肽162-181的测定的氨基酸序列。

SEQ ID NO：249是沙眼衣原体OMCB肽167-186的测定的氨基酸序列。

SEQ ID NO：250是沙眼衣原体OMCB肽171-190的测定的氨基酸序列。

SEQ ID NO：251是沙眼衣原体OMCB肽171-186的测定的氨基酸序列。

SEQ ID NO：252是沙眼衣原体OMCB肽175-186的测定的氨基酸序列。

SEQ ID NO：253是肺炎衣原体OMCB肽185-198的测定的氨基酸序列。

SEQ ID NO：254是沙眼衣原体TSA肽96-115的测定的氨基酸序列。

SEQ ID NO：255是沙眼衣原体TSA肽101-120的测定的氨基酸序列。

SEQ ID NO：256是沙眼衣原体TSA肽106-125的测定的氨基酸序列。

SEQ ID NO：257是沙眼衣原体TSA肽111-130的测定的氨基酸序列。

SEQ ID NO：258是沙眼衣原体TSA肽116-135的测定的氨基酸序列。

SEQ ID NO：259是沙眼衣原体TSA肽121-140的测定的氨基酸序列。

SEQ ID NO：260是沙眼衣原体TSA肽126-145的测定的氨基酸序列。

SEQ ID NO：261是沙眼衣原体TSA肽131-150的测定的氨基酸序列。

SEQ ID NO：262是沙眼衣原体TSA肽136-155的测定的氨基酸序列。

SEQ ID NO：263是沙眼衣原体CT529/Cap 1基因血清变型I的测定的全长DNA序列。

SEQ ID NO：264是沙眼衣原体CT529/Cap 1基因血清变型I的预测的全长氨基酸序列。

SEQ ID NO：265是沙眼衣原体CT529/Cap 1基因血清变型K的测定的全长DNA序列。

SEQ ID NO：266是沙眼衣原体CT529/Cap 1基因血清变型K的预测的全长氨基酸序列。

SEQ ID NO：267是沙眼衣原体克隆17-G4-36的测定的DNA序列，与DNA指导的RNA聚合酶β亚基ORF(serD中的CT315)的一部分有同源性。

SEQ ID NO：268是克隆2E10中沙眼衣原体CT016基因的部分序列的测定的DNA序列。

SEQ ID NO：269是克隆2E10中沙眼衣原体tRNA合成酶基因的部分序列的测定的DNA序列。

SEQ ID NO：270是克隆2E10中沙眼衣原体clpX基因的部分序列的测定的DNA序列。

SEQ ID NO：271是沙眼衣原体克隆CtL2gam-30第一个测定的DNA序列，代表5’端。

SEQ ID NO：272是沙眼衣原体克隆CtL2gam-30第二个测定的DNA序列，代表3’端。

SEQ ID NO：273是沙眼衣原体克隆CtL2gam-28的测定的DNA序列。

SEQ ID NO：274是沙眼衣原体克隆CtL2gam-27的测定的DNA序列。

SEQ ID NO：275是沙眼衣原体克隆CtL2gam-26的测定的DNA序列。

SEQ ID NO：276是沙眼衣原体克隆CtL2gam-24的测定的DNA序列。

SEQ ID NO：277是沙眼衣原体克隆CtL2gam-23的测定的DNA序列。

SEQ ID NO：278是沙眼衣原体克隆CtL2gam-21的测定的DNA序列。

SEQ ID NO：279是沙眼衣原体克隆CtL2gam-18的测定的DNA序列。

SEQ ID NO：280是沙眼衣原体克隆CtL2gam-17的测定的DNA序列。

SEQ ID NO：281是沙眼衣原体克隆CtL2gam-15第一个测定的DNA序列，代表5’端。

SEQ ID NO：282是沙眼衣原体克隆CtL2gam-15第二个测定的DNA序列，代表3’端。

SEQ ID NO：283是沙眼衣原体克隆CtL2gam-13的测定的DNA序列。

SEQ ID NO：284是沙眼衣原体克隆CtL2gam-10的测定的DNA序列。

SEQ ID NO：285是沙眼衣原体克隆CtL2gam-8的测定的DNA序列。

SEQ ID NO：286是沙眼衣原体克隆CtL2gam-6第一个测定的DNA序列，代表5’端。

SEQ ID NO：287是沙眼衣原体克隆CtL2gam-6第二个测定的DNA序列，代表3’端。

SEQ ID NO：288是沙眼衣原体克隆CtL2gam-5的测定的DNA序列。

SEQ ID NO：289是沙眼衣原体克隆CtL2gam-2的测定的DNA序列。

SEQ ID NO：290是沙眼衣原体克隆CtL2gam-1的测定的DNA序列。

SEQ ID NO：291是CT529基因的肺炎衣原体同系物(homologue)的测定的全长DNA序列。

SEQ ID NO：292是CT529基因的肺炎衣原体同系物的预测的全长氨基酸序列。

SEQ ID NO：293是用于在SKB疫苗载体中克隆沙眼衣原体pmpG基因的插入序列的测定的DNA序列。

SEQ ID NO：294是克隆CT603的可读框的氨基酸序列。

SEQ ID NO：295是克隆CT875的第一可读框的氨基酸序列。

SEQ ID NO：296是克隆CT875的第二可读框的氨基酸序列。

SEQ ID NO：297是克隆CT858的第一可读框的氨基酸序列。

SEQ ID NO：298是克隆CT858的第二可读框的氨基酸序列。

SEQ ID NO：299是克隆CT622的可读框的氨基酸序列。

SEQ ID NO：300是克隆CT610的可读框的氨基酸序列。

SEQ ID NO：301是克隆CT396的可读框的氨基酸序列。

SEQ ID NO：302是克隆CT318的可读框的氨基酸序列。

SEQ ID NO：304是沙眼衣原体血清变型L2 rCt529c1-125的氨基酸序列，具有修饰的N端序列(6-His tag)。

SEQ ID NO：305是沙眼衣原体血清变型L2 rCt529c1-125的氨基酸序列。

SEQ ID NO：306是PmpA(N-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：307是PmpA(N-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：308是编码PmpA(N-term)融合蛋白的DNA序列。

SEQ ID NO：309是PmpA(N-term)融合蛋白的氨基酸序列。

SEQ ID NO：310是PmpA(C-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：311是PmpA(C-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：312是编码PmpA(C-term)融合蛋白的DNA序列。

SEQ ID NO：313是PmpA(C-term)融合蛋白的氨基酸序列。

SEQ ID NO：314是PmpF(N-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：315是PmpF(N-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：316是编码PmpF(N-term)融合蛋白的DNA序列。

SEQ ID NO：317是PmpF(N-term)融合蛋白的氨基酸序列。

SEQ ID NO：318是PmpF(C-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：319是PmpF(C-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：320是编码PmpF(C-term)融合蛋白的DNA序列。

SEQ ID NO：321是PmpF(C-term)融合蛋白的氨基酸序列。

SEQ ID NO：322是PmpH(CT412)(N-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：323是PmpH(N-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：324是编码PmpH(N-term)融合蛋白的DNA序列。

SEQ ID NO：325是PmpH(N-term)融合蛋白的氨基酸序列。

SEQ ID NO：326是PmpH(C-term)融合蛋白的合成中使用的有义引物。

SEQ ID NO：327是PmpH(C-term)融合蛋白的合成中使用的反义引物。

SEQ ID NO：328是编码PmpH(C-term)融合蛋白的DNA序列。

SEQ ID NO：329是PmpH(C-term)融合蛋白的氨基酸序列。

SEQ ID NO：330是PmpB(1)融合蛋白的合成中使用的有义引物。

SEQ ID NO：331是PmpB(1)融合蛋白的合成中使用的反义引物。

SEQ ID NO：332是编码PmpB(1)融合蛋白的DNA序列。

SEQ ID NO：333是PmpB(1)融合蛋白的氨基酸序列。

SEQ ID NO：334是PmpB(2)融合蛋白的合成中使用的有义引物。

SEQ ID NO：335是PmpB(2)融合蛋白的合成中使用的反义引物。

SEQ ID NO：336是编码PmpB(2)融合蛋白的DNA序列。

SEQ ID NO：337是PmpB(2)融合蛋白的氨基酸序列。

SEQ ID NO：338是PmpB(3)融合蛋白的合成中使用的有义引物。

SEQ ID NO：339是PmpB(3)融合蛋白的合成中使用的反义引物。

SEQ ID NO：340是编码PmpB(3)融合蛋白的DNA序列。

SEQ ID NO：341是PmpB(3)融合蛋白的氨基酸序列。

SEQ ID NO：342是PmpB(4)融合蛋白的合成中使用的有义引物。

SEQ ID NO：343是PmpB(4)融合蛋白的合成中使用的反义引物。

SEQ ID NO：344是编码PmpB(4)融合蛋白的DNA序列。

SEQ ID NO：345是PmpB(4)融合蛋白的氨基酸序列。

SEQ ID NO：346是PmpC(1)融合蛋白的合成中使用的有义引物。

SEQ ID NO：347是PmpC(1)融合蛋白的合成中使用的反义引物。

SEQ ID NO：348是编码PmpC(1)融合蛋白的DNA序列。

SEQ ID NO：349是PmpC(1)融合蛋白的氨基酸序列。

SEQ ID NO：350是PmpC(2)融合蛋白的合成中使用的有义引物。

SEQ ID NO：351是PmpC(2)融合蛋白的合成中使用的反义引物。

SEQ ID NO：352是编码PmpC(2)融合蛋白的DNA序列。

SEQ ID NO：353是PmpC(2)融合蛋白的氨基酸序列。

SEQ ID NO：354是PmpC(3)融合蛋白的合成中使用的有义引物。

SEQ ID NO：355是PmpC(3)融合蛋白的合成中使用的反义引物。

SEQ ID NO：356是编码PmpC(3)融合蛋白的DNA序列。

SEQ ID NO：357是PmpC(3)融合蛋白的氨基酸序列。

SEQ ID NO：358是oppA1蛋白质的DNA序列，缺少第一跨膜域。

SEQ ID NO：359是CT139的全长DNA序列。

SEQ ID NO：360是ORF-3的全长DNA序列。

SEQ ID NO：361是CT611的全长DNA序列。

SEQ ID NO：362是oppA1的氨基酸序列，从第22位氨基酸开始。

SEQ ID NO：363是CT139的氨基酸序列。

SEQ ID NO：364是ORF-3的氨基酸序列。

SEQ ID NO：365是CT611的氨基酸序列。

SEQ ID NO：366显示了沙眼衣原体基因CT190的肺炎衣原体同系物CPn0275的DNA序列。

SEQ ID NO：367显示了沙眼衣原体基因CT103的肺炎衣原体同系物CPn0407的DNA序列。

SEQ ID NO：368显示了沙眼衣原体基因CT659的肺炎衣原体同系物CPn0720的DNA序列。

SEQ ID NO：369显示了沙眼衣原体基因CT660的肺炎衣原体同系物CPn0716的DNA序列。

SEQ ID NO：370显示了沙眼衣原体基因CT430的肺炎衣原体同系物CPn0519的DNA序列。

SEQ ID NO：371显示了沙眼衣原体基因CT431的肺炎衣原体同系物CPn0520的DNA序列。

SEQ ID NO：372显示了沙眼衣原体基因CT318的肺炎衣原体同系物CPn0078的DNA序列。

SEQ ID NO：373显示了沙眼衣原体基因CT509的肺炎衣原体同系物CPn0628的DNA序列。

SEQ ID NO：374显示了沙眼衣原体基因CT414的肺炎衣原体同系物CPn0540的DNA序列。

SEQ ID NO：375显示了沙眼衣原体基因CT413的肺炎衣原体同系物pmp20的DNA序列。

SEQ ID NO：376显示了沙眼衣原体基因CT315的肺炎衣原体同系物CPn0081的DNA序列。

SEQ ID NO：377显示了沙眼衣原体基因CT610的肺炎衣原体同系物CPn0761的DNA序列。

SEQ ID NO：378显示了沙眼衣原体基因CT443的肺炎衣原体同系物CPn0557的DNA序列。

SEQ ID NO：379显示了沙眼衣原体基因CT557的肺炎衣原体同系物CPn0833的DNA序列。

SEQ ID NO：380显示了沙眼衣原体基因CT604的肺炎衣原体同系物CPn0134的DNA序列。

SEQ ID NO：381显示了沙眼衣原体基因CT042的肺炎衣原体同系物CPn0388的DNA序列。

SEQ ID NO：382显示了沙眼衣原体基因CT376的肺炎衣原体同系物CPn1028的DNA序列。

SEQ ID NO：383显示了沙眼衣原体基因CT734的肺炎衣原体同系物CPn0875的DNA序列。

SEQ ID NO：384显示了沙眼衣原体基因CT764的肺炎衣原体同系物CPn0908的DNA序列。

SEQ ID NO：385显示了沙眼衣原体基因CT622的肺炎衣原体同系物CPn0728的DNA序列。

SEQ ID NO：386显示了沙眼衣原体基因CT190的肺炎衣原体同系物CPn0275的氨基酸序列。

SEQ ID NO：387显示了沙眼衣原体基因CT103的肺炎衣原体同系物CPn0407的氨基酸序列。

SEQ ID NO：388显示了沙眼衣原体基因CT659的肺炎衣原体同系物CPn0720的氨基酸序列。

SEQ ID NO：389显示了沙眼衣原体基因CT660的肺炎衣原体同系物CPn0716的氨基酸序列。

SEQ ID NO：390显示了沙眼衣原体基因CT430的肺炎衣原体同系物CPn0519的氨基酸序列。

SEQ ID NO：391显示了沙眼衣原体基因CT431的肺炎衣原体同系物CPn0520的氨基酸序列。

SEQ ID NO：392显示了沙眼衣原体基因CT318的肺炎衣原体同系物CPn0078的氨基酸序列。

SEQ ID NO：393显示了沙眼衣原体基因CT509的肺炎衣原体同系物CPn0628的氨基酸序列。

SEQ ID NO：394显示了沙眼衣原体基因CT414的肺炎衣原体同系物CPn0540的氨基酸序列。

SEQ ID NO：395显示了沙眼衣原体基因CT413的肺炎衣原体同系物pmp20的氨基酸序列。

SEQ ID NO：396显示了沙眼衣原体基因CT315的肺炎衣原体同系物CPn0081的氨基酸序列。

SEQ ID NO：397显示了沙眼衣原体基因CT610的肺炎衣原体同系物CPn0761的氨基酸序列。

SEQ ID NO：398显示了沙眼衣原体基因CT443的肺炎衣原体同系物CPn0557的氨基酸序列。

SEQ ID NO：399显示了沙眼衣原体基因CT557的肺炎衣原体同系物CPn0833的氨基酸序列。

SEQ ID NO：400显示了沙眼衣原体基因CT604的肺炎衣原体同系物CPn0134的氨基酸序列。

SEQ ID NO：401显示了沙眼衣原体基因CT042的肺炎衣原体同系物CPn0388的氨基酸序列。

SEQ ID NO：402显示了沙眼衣原体基因CT376的肺炎衣原体同系物CPn1028的氨基酸序列。

SEQ ID NO：403显示了沙眼衣原体基因CT734的肺炎衣原体同系物CPn0875的氨基酸序列。

SEQ ID NO：404显示了沙眼衣原体基因CT764的肺炎衣原体同系物CPn0908的氨基酸序列。

SEQ ID NO：405显示了沙眼衣原体基因CT622的肺炎衣原体同系物CPn0728的氨基酸序列。

SEQ ID NO：406显示了沙眼衣原体基因CT287的全长血清变型DDNA序列。

SEQ ID NO：407显示了沙眼衣原体基因CT858的全长血清变型DDNA序列。

SEQ ID NO：408显示了沙眼衣原体基因CT764的全长血清变型DDNA序列。

SEQ ID NO：409显示了沙眼衣原体基因CT734的全长血清变型DDNA序列。

SEQ ID NO：410显示了沙眼衣原体基因CT660的全长血清变型DDNA序列。

SEQ ID NO：411显示了沙眼衣原体基因CT659的全长血清变型DDNA序列。

SEQ ID NO：412显示了沙眼衣原体基因CT622的全长血清变型DDNA序列。

SEQ ID NO：413显示了沙眼衣原体基因CT610的全长血清变型DDNA序列。

SEQ ID NO：414显示了沙眼衣原体基因CT604的全长血清变型DDNA序列。

SEQ ID NO：415显示了沙眼衣原体基因CT557的全长血清变型DDNA序列。

SEQ ID NO：416显示了沙眼衣原体基因CT509的全长血清变型DDNA序列。

SEQ ID NO：417显示了沙眼衣原体基因CT443的全长血清变型DDNA序列。

SEQ ID NO：418显示了沙眼衣原体基因CT431的全长血清变型DDNA序列。

SEQ ID NO：419显示了沙眼衣原体基因CT430的全长血清变型DDNA序列。

SEQ ID NO：420显示了沙眼衣原体基因CT414的全长血清变型DDNA序列。

SEQ ID NO：421显示了沙眼衣原体基因CT413的全长血清变型DDNA序列。

SEQ ID NO：422显示了沙眼衣原体基因CT396的全长血清变型DDNA序列。

SEQ ID NO：423显示了沙眼衣原体基因CT376的全长血清变型DDNA序列。

SEQ ID NO：424显示了沙眼衣原体基因CT318的全长血清变型DDNA序列。

SEQ ID NO：425显示了沙眼衣原体基因CT315的全长血清变型DDNA序列。

SEQ ID NO：426显示了沙眼衣原体基因CT104的全长血清变型DDNA序列。

SEQ ID NO：427显示了沙眼衣原体基因CT103的全长血清变型DDNA序列。

SEQ ID NO：428显示了沙眼衣原体基因CT102的全长血清变型DDNA序列。

SEQ ID NO：429显示了沙眼衣原体基因CT098的全长血清变型DDNA序列。

SEQ ID NO：430显示了沙眼衣原体基因CT042的全长血清变型DDNA序列。

SEQ ID NO：431显示了沙眼衣原体基因CT858的全长血清变型D氨基酸序列。

SEQ ID NO：432显示了沙眼衣原体基因CT764的全长血清变型D氨基酸序列。

SEQ ID NO：433显示了沙眼衣原体基因CT734的全长血清变型D氨基酸序列。

SEQ ID NO：434显示了沙眼衣原体基因CT660的全长血清变型D氨基酸序列。

SEQ ID NO：435显示了沙眼衣原体基因CT659的全长血清变型D氨基酸序列。

SEQ ID NO：436显示了沙眼衣原体基因CT622的全长血清变型D氨基酸序列。

SEQ ID NO：437显示了沙眼衣原体基因CT610的全长血清变型D氨基酸序列。

SEQ ID NO：438显示了沙眼衣原体基因CT604的全长血清变型D氨基酸序列。

SEQ ID NO：439显示了沙眼衣原体基因CT557的全长血清变型D氨基酸序列。

SEQ ID NO：440显示了沙眼衣原体基因CT509的全长血清变型D氨基酸序列。

SEQ ID NO：441显示了沙眼衣原体基因CT443的全长血清变型D氨基酸序列。

SEQ ID NO：442显示了沙眼衣原体基因CT431的全长血清变型D氨基酸序列。

SEQ ID NO：443显示了沙眼衣原体基因CT430的全长血清变型D氨基酸序列。

SEQ ID NO：444显示了沙眼衣原体基因CT414的全长血清变型D氨基酸序列。

SEQ ID NO：445显示了沙眼衣原体基因CT413的全长血清变型D氨基酸序列。

SEQ ID NO：446显示了沙眼衣原体基因CT396的全长血清变型D氨基酸序列。

SEQ ID NO：447显示了沙眼衣原体基因CT376的全长血清变型D氨基酸序列。

SEQ ID NO：448显示了沙眼衣原体基因CT318的全长血清变型D氨基酸序列。

SEQ ID NO：449显示了沙眼衣原体基因CT315的全长血清变型D氨基酸序列。

SEQ ID NO：450显示了沙眼衣原体基因CT104的全长血清变型D氨基酸序列。

SEQ ID NO：451显示了沙眼衣原体基因CT103的全长血清变型D氨基酸序列。

SEQ ID NO：452显示了沙眼衣原体基因CT102的全长血清变型D氨基酸序列。

SEQ ID NO：453显示了沙眼衣原体基因CT098的全长血清变型D氨基酸序列。

SEQ ID NO：454显示了沙眼衣原体基因CT042的全长血清变型D氨基酸序列。

SEQ ID NO：455相应于CPn0894的DNA序列，其是在克隆CTL2-1，和CTL2-5中鉴定到的CT751(amn)的CP同系物。

SEQ ID NO：456相应于CPn0074的DNA序列，其是在克隆CTL2-2中鉴定到的CT322(tuf)的CP同系物。

SEQ ID NO：457相应于CPn0122的DNA序列，其是在克隆CTL2gam2，CTL2-3(5’)和CTL2-4中鉴定到的CT032(metG)的CP同系物。

SEQ ID NO：458相应于CPn0121的DNA序列，其是在克隆CTL2-3(5’)(3’)中鉴定到的CT031的CP同系物。

SEQ ID NO：459相应于CPn0120的DNA序列，其是在克隆CTL2-3(3’)和CTL2-21中鉴定到的CT030(gmK)的CP同系物。

SEQ ID NO：460相应于CPn0359的DNA序列，其是在克隆CTL2gam5中鉴定到的CT064(lepA)的CP同系物。

SEQ ID NO：461相应于CPn0414的DNA序列，其是在克隆CTL2-6中鉴定到的CT265(accA)的CP同系物。

SEQ ID NO：462相应于CPn0413的DNA序列，其是在克隆CTL2-6中鉴定到的CT264(msbA)的CP同系物。

SEQ ID NO：463相应于CPn0394的DNA序列，其是在克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的CT256的CP同系物。

SEQ ID NO：464相应于CPn0395的DNA序列，其是在克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的CT257的CP同系物。

SEQ ID NO：465相应于CPn0487的DNA序列，其是在克隆CTL2gam6(3’)和CTL2-11(3’)中鉴定到的CT384的CP同系物。

SEQ ID NO：466相应于CPn0592的DNA序列，其是在克隆CTL2-8b中鉴定到的CT473的CP同系物。

SEQ ID NO：467相应于CPn0593的DNA序列，其是在克隆CTL2-8b中鉴定到的CT474的CP同系物。

SEQ ID NO：468相应于CPn0197的DNA序列，其是在克隆CTL2-8b中鉴定到的CT139(oppA1)的CP同系物。

SEQ ID NO：469相应于CPn0363的DNA序列，其是在克隆CTL2-8b中鉴定到的CT060(flhA)的CP同系物。

SEQ ID NO：470相应于CPn0301的DNA序列，其是在克隆CTL2gam8中鉴定得的CT242的CP同系物。

SEQ ID NO：471相应于CPn0302的DNA序列，其是在克隆CTL2gam8中鉴定到的CT243(lpxD)的CP同系物。

SEQ ID NO：472相应于CPn0324的DNA序列，其是在克隆CTL2-9，CTL2gam1，CTL2gam17和CTL2-19(5’)中鉴定到的CT089(lcrE)的CP同系物。

SEQ ID NO：473相应于CPn0761的DNA序列，其是在克隆CTL2-10(5’)(3’)中鉴定到的CT610的CP同系物。

SEQ ID NO：474相应于CPn0760的DNA序列，其是在克隆CTL2-10(5’)中鉴定到的CT611的CP同系物。

SEQ ID NO：475相应于CPn0329的DNA序列，其是在克隆CTL2gam10和CTL2gam21中鉴定到的CT154的CP同系物。

SEQ ID NO：476相应于CPn0990的DNA序列，其是在克隆CTL2-12中鉴定到的CT833(infC)的CP同系物。

SEQ ID NO：477相应于CPn0984的DNA序列，其是在克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的CT827(nrdA)的CP同系物。

SEQ ID NO：478相应于CPn0985的DNA序列，其是在克隆CTL2-16(3’)CTL2gam15(3’)中鉴定到的CT828(nrdB)的CP同系物。

SEQ ID NO：479相应于CPn0349的DNA序列，其是在克隆CTL2gam18中鉴定到的CT067(ytgA)的CP同系物。

SEQ ID NO：480相应于CPn0325的DNA序列，其是在克隆CTL2-19(5’)中鉴定到的CT088(sycE)的CP同系物。

SEQ ID NO：481相应于CPn0326的DNA序列，其是在克隆CTL2-19(5’)中鉴定到的CT087(malQ)的CP同系物。

SEQ ID NO：482相应于CPn0793的DNA序列，其是在克隆CTL2gam23中鉴定到的CT588(rbsu)的CP同系物。

SEQ ID NO：483相应于CPn0199的DNA序列，其是在克隆CTL2gam24中鉴定到的CT199(oppB1)的CP同系物。

SEQ ID NO：484相应于CPn0666的DNA序列，其是在克隆CTL2-24中鉴定到的CT545(dnaE)的CP同系物。

SEQ ID NO：485相应于CPn0065的DNA序列，其是在克隆CTL2gam27中鉴定到的CT288的CP同系物。

SEQ ID NO：486相应于CPn0444的DNA序列，其是在克隆CTL2gam30(5’)(3’)中鉴定到的CT413(pmpB)的CP同系物。

SEQ ID NO：487相应于CPn-ORF5的DNA序列，其是在克隆CTL2gam15(5’)，CTL2-16(5’)，CTL2-18(5’)，和CTL2-23中鉴定到的CT-ORF3的CP同系物。

SEQ ID NO：488相应于CPn-ORF6的DNA序列，其是在克隆CTL2-18(3’)中鉴定到的CT-ORF4的CP同系物。

SEQ ID NO：489相应于CP-ORF7的DNA序列，其是在克隆CTL2-18(3’)中鉴定到的CT-ORF5的CP同系物。

SEQ ID NO：490相应于CPn0894的氨基酸序列，其是在克隆CTL2-1和CTL2-5中鉴定到的CT751(amn)的CP同系物。

SEQ ID NO：491相应于CPn0074的氨基酸序列，其是在克隆CTL2-2中鉴定到的CT332(tuf)的CP同系物。

SEQ ID NO：492相应于CPn0122的氨基酸序列，其是在克隆CTL2gam2，CTL2-3(5’)和CTL2-4中鉴定到的CT032(metG)的CP同系物。

SEQ ID NO：493相应于CPn0121的氨基酸序列，其是在克隆CTL2-3(5’)(3’)中鉴定到的CT031的CP同系物。

SEQ ID NO：494相应于CPn0120的氨基酸序列，其是在克隆CTL2-3(3’)和CTL2-21中鉴定到的CT030(gmK)的CP同系物。

SEQ ID NO：495相应于CPn0359的氨基酸序列，其是在克隆CTL2gam5中鉴定到的的CT064(lepA)CP同系物。

SEQ ID NO：496相应于CPn0414的氨基酸序列，其是在克隆CTL2-6中鉴定到的CT265(accA)的CP同系物。

SEQ ID NO：497相应于的氨基酸序列CPn0413，其是在克隆CTL2-6中鉴定到的CT264(msbA)的CP同系物。

SEQ ID NO：498相应于CPn0394的氨基酸序列，其是在克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的CT256的CP同系物。

SEQ ID NO：499相应于CPn0395的氨基酸序列，其是在克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的CT257的CP同系物。

SEQ ID NO：500相应于CPn0487的氨基酸序列，其是克隆CTL2gam6(3’)和CTL2-11(3’)中鉴定到的CT384的CP同系物。

SEQ ID NO：501相应于CPn0592的氨基酸序列，其是在克隆CTL2-8b中鉴定到的CT473的CP同系物。

SEQ ID NO：502相应于CPn0593的氨基酸序列，其是在克隆CTL2-8b中鉴定到的CT474的CP同系物。

SEQ ID NO：503相应于CPn0197的氨基酸序列，其是在克隆CTL2-8b中鉴定到的CT139(oppA1)的CP同系物。

SEQ ID NO：504相应于CPn0363的氨基酸序列，其是在克隆CTL2-8b中鉴定到的CT060(flhA)的CP同系物。

SEQ ID NO：505相应于CPn0301的氨基酸序列，其是在克隆CTL2gam8中鉴定到的CT242的CP同系物。

SEQ ID NO：506相应于CPn0302的氨基酸序列，其是在克隆CTL2gam8中鉴定到的CT243(lpxD)的CP同系物。

SEQ ID NO：507相应于CPn0324的氨基酸序列，其是在克隆CTL2-9，CTL2gam1，CTL2gam17和CTL2-19(5’)中鉴定到的CT089(lcrE)的CP同系物。

SEQ ID NO：508相应于CPn0761的氨基酸序列，其是在克隆CTL2-10(5’)(3’)中鉴定到的CT610的CP同系物。

SEQ ID NO：509相应于的氨基酸序列CPn0760，其是在克隆CTL2-10(5’)中鉴定到的CT611的CP同系物。

SEQ ID NO：510相应于的氨基酸序列CPn0329，其是在克隆CTL2gam10和CTL2gam21中鉴定到的CT154的CP同系物。

SEQ ID NO：511相应于CPn0990的氨基酸序列，其是在克隆CTL2-12中鉴定到的CT833(infC)的CP同系物。

SEQ ID NO：512相应于CPn-ORF5的氨基酸序列，其是在克隆CTL2gam15(5’)，CTL2-16(5’)，CTL2-18(5’)，和CTL2-23中鉴定到的CT ORF3的CP同系物。

SEQ ID NO：513相应于的氨基酸序列CPn0984，其是在克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的CT827(nrdA)的CP同系物。

SEQ ID NO：514相应于CPn0985的氨基酸序列，其是在克隆CTL2-16(3’)CTL2gam15(3’)中鉴定到的CT828(nrdB)的CP同系物。

SEQ ID NO：515相应于CPn0349的氨基酸序列，其是在克隆CTL2gam18中鉴定到的CT067(ytgA)的CP同系物。

SEQ ID NO：516相应于CPn-ORF6的DNA序列，其是在克隆CTL2-18(3’)中鉴定到的CT-ORF4的CP同系物。

SEQ ID NO：517相应于CP-ORF7的DNA序列，其是在克隆CTL2-18(3’)中鉴定到的CT-ORF5的CP同系物。

SEQ ID NO：518相应于CPn0326的氨基酸序列，其是在克隆CTL2-19(5’)中鉴定到的CT087(malQ)的CP同系物。

SEQ ID NO：519相应于CPn0325的氨基酸序列，其是在克隆CTL2-19(5’)中鉴定到的CT088(sycE)的CP同系物。

SEQ ID NO：520相应于CPn0793的氨基酸序列，其是在克隆CTL2gam23中鉴定到的CT588(rbsu)的CP同系物。

SEQ ID NO：521相应于CPn0199的氨基酸序列，其是在克隆CTL2gam24中鉴定到的CT199(oppB1)的CP同系物。

SEQ ID NO：522相应于CPn0666的氨基酸序列，其是在克隆CTL2-24中鉴定到的CT545(dnaE)的CP同系物。

SEQ ID NO：523相应于CPn0065的DNA序列，其是在克隆CTL2gam27中鉴定到的CT288的CP同系物。

SEQ ID NO：524相应于CPn0444的DNA序列，其是在克隆CTL2gam30(5’)(3’)中鉴定到的CT413(pmpB)的CP同系物。

SEQ ID NO：525显示了与从克隆CTL2-1和CTL2-5中鉴定到的沙眼衣原体LGV II序列CT751(amn)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：526显示了与从克隆CTL2-2中鉴定到的沙眼衣原体LGV II序列CT322(tuff)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：527显示了与从克隆CTL2gam2，CTL2-3(5’)和CTL2-4中鉴定到的沙眼衣原体LGV II序列CT032(metG)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：528显示了与从克隆CTL2-3(5’)(3’)中鉴定到的沙眼衣原体LGV II序列CT031同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：529显示了与从克隆CTL2-3(3’)和CTL2-21中鉴定到的沙眼衣原体LGV II序列CT030(gmK)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：530显示了与从克隆CTL2gam5中鉴定到的沙眼衣原体LGV II序列CT064(lepA)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：531显示了与从克隆CTL2-6中鉴定到的沙眼衣原体LGV II序列CT265(accA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：532显示了与从克隆CTL2-6中鉴定到的沙眼衣原体LGV II序列CT624(msbA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：533显示了与从克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的沙眼衣原体LGV II序列CT256同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：534显示了与从克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的沙眼衣原体LGV II序列CT257同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：535显示了与从克隆CTL2gam6(3’)和CTL2-11(3’)中鉴定到的沙眼衣原体LGV II序列CT384同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：536显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT473同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：537显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT474同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：538显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT139(oppA1)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：539显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT060(flhA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：540显示了与从克隆CTL2gam8中鉴定到的沙眼衣原体LGV II序列CT242同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：541显示了与从克隆CTL2gam8中鉴定到的沙眼衣原体LGV II序列CT243(lpxD)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：542显示了与从克隆CTL2-9，CTL2gam1，CTL2gam17，和CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT089同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：543显示了与从克隆CTL2-10(5’)(3’)中鉴定到的沙眼衣原体LGV II序列CT610同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：544显示了与从克隆CTL2-10(5’)中鉴定到的沙眼衣原体LGV II序列CT611同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：545显示了与从克隆CTL2gam10和CTL2gam21中鉴定到的沙眼衣原体LGV II序列CT154同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：546显示了与从克隆CTL2-12中鉴定到的沙眼衣原体LGV II序列CT833(infC)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：547显示了与从克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的沙眼衣原体LGV II序列CT827(nrdA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：548显示了与从克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的沙眼衣原体LGV II序列CT828(nrdB)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：549显示了与从克隆CTL2gam18中鉴定到的沙眼衣原体LGV II序列CT067(ytgA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：550显示了与从克隆CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT088(sycE)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：551显示了与从克隆CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT087同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：552显示了与从克隆CTL2gam23中鉴定到的沙眼衣原体LGV II序列CT588(rsbu)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：553显示了与从克隆CTL2gam24中鉴定到的沙眼衣原体LGV II序列CT199(oppB1)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：554显示了与从克隆CTL2-4中鉴定到的沙眼衣原体LGV II序列CT545(dnaE)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：555显示了与从克隆CTL2gam27中鉴定到的沙眼衣原体LGV II序列CT288同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：556显示了与从克隆CTL2gam30(5’)(3’)中鉴定到的沙眼衣原体LGV II序列CT413(pmpB)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：557显示了与从克隆CTL2gam15(5’)，CTL2-16(5’)，CTL2-18(5’)和CTL2-23中鉴定到的沙眼衣原体LGV II序列CT-ORF3同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：558显示了与从克隆CTL2-18(3’)中鉴定到的沙眼衣原体LGV II序列pCT-ORF4同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：559显示了与从克隆CTL2-18(3’)中鉴定到的沙眼衣原体LGV II序列CT-ORF5同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：560显示了与从克隆CTL2-1和CTL2-5中鉴定到的沙眼衣原体LGV II序列CT751(amn)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：561显示了与从克隆CTL2-2中鉴定到的沙眼衣原体LGV II序列CT322(tuff)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：562显示了与从克隆CTL2gam2，CTL2-3(5’)和CTL2-4中鉴定到的沙眼衣原体LGV II序列CT032(metG)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：563显示了与从克隆CTL2-3(5’)(3’)中鉴定到的沙眼衣原体LGV II序列CT031同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：564显示了与从克隆CTL2-3(3’)和CTL2-21中鉴定到的沙眼衣原体LGV II序列CT030(gmK)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：565显示了与从克隆CTL2gam5中鉴定到的沙眼衣原体LGV II序列CT064(lepA)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：566显示了与从克隆CTL2-6中鉴定到的沙眼衣原体LGV II序列CT265(accA)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：567显示了与从克隆CTL2-6中鉴定到的沙眼衣原体LGV II序列CT624(msbA)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：568显示了与从克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的沙眼衣原体LGV II序列CT256同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：569显示了与从克隆CTL2gam6(5’)和CTL2-11(5’)中鉴定到的沙眼衣原体LGV II序列CT257同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：570显示了与从克隆CTL2gam6(3’)和CTL2-11(3’)中鉴定到的沙眼衣原体LGV II序列CT384同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：571显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT473同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：572显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT474同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：573显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT139(oppA1)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：574显示了与从克隆CTL2-8b中鉴定到的沙眼衣原体LGV II序列CT060(flhA)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：575显示了与从克隆CTL2gam8中鉴定到的沙眼衣原体LGV II序列CT242同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：576显示了与从克隆CTL2gam8中鉴定到的沙眼衣原体LGV II序列CT243(lpxD)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：577显示了与从克隆CTL2-9，CTL2gam1，CTL2gam17，和CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT089同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：578显示了与从克隆CTL2-10(5’)(3’)中鉴定到的沙眼衣原体LGV II序列CT610同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：579显示了与从克隆CTL2-10(5’)中鉴定到的沙眼衣原体LGV II序列CT611同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：580显示了与从克隆CTL2gam10和CTL2gam21中鉴定到的沙眼衣原体LGV II序列CT154同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：581显示了与从克隆CTL2-12中鉴定到的沙眼衣原体LGV II序列CT833(infC)同源的全长沙眼衣原体血清变型D氨基酸序列。

SEQ ID NO：582显示了与从克隆CTL2gam15(5’)，CTL2-16(5’)，CTL2-18(5’)和CTL2-23中鉴定到的沙眼衣原体LGV II序列CT-ORF3同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：583显示了与从克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的沙眼衣原体LGV II序列CT827(nrdA)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：584显示了与从克隆CTL2-16(3’)和CTL2gam15(3’)中鉴定到的沙眼衣原体LGV II序列CT828(nrdB)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：585显示了与从克隆CTL2gam18中鉴定到的沙眼衣原体LGV II序列CT067(ytgA)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：586显示了与从克隆CTL2-18(3’)中鉴定到的沙眼衣原体LGV II序列pCT-ORF4同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：587显示了与从克隆CTL2-18(3’)中鉴定到的沙眼衣原体LGV II序列CT-ORF5同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：588显示了与从克隆CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT087同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：589显示了与从克隆CTL2-19(5’)中鉴定到的沙眼衣原体LGV II序列CT088(sycE)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：590显示了与从克隆CTL2gam23中鉴定到的沙眼衣原体LGV II序列CT588(rsbu)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：591显示了与从克隆CTL2gam24中鉴定到的沙眼衣原体LGV II序列CT199(oppB1)同源的全长沙眼衣原体血清变型DDNA序列。

SEQ ID NO：592显示了与从克隆CTL2-4中鉴定到的沙眼衣原体LGV II序列CT545(dnaE)同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：593显示了与从克隆CTL2gam27中鉴定到的沙眼衣原体LGV II序列CT288同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：594显示了与从克隆CTL2gam30(5’)(3’)中鉴定到沙眼衣原体LGV II序列CT413(pmpB)的同源的全长沙眼衣原体血清变型D DNA序列。

SEQ ID NO：595显示了沙眼衣原体基因CT102的肺炎衣原体同系物CPn0406的DNA序列。

SEQ ID NO：596显示了沙眼衣原体基因CT098的肺炎衣原体同系物CPn0315的DNA序列。

SEQ ID NO：597显示了沙眼衣原体基因CT102的肺炎衣原体同系物CPn0406的氨基酸序列。

SEQ ID NO：598显示了沙眼衣原体基因CT098的肺炎衣原体同系物CPn0315的氨基酸序列。

SEQ ID NO：599显示了沙眼衣原体血清变型D CT287蛋白质的氨基酸序列。

附图简述

图1图示了从表达克隆4C9-18#2的靶细胞所激活的衣原体特异性T细胞系诱导INF-γ。

图2图示了经修饰含有Kosak翻译起始位点和终止密码子的逆转录病毒载体pBIB-KS1，2，3。

图3显示铬释放试验中经衣原体肽GtC7.8-12(SEQ ID NO：18)和CtC7.8-13(SEQ ID NO：19)脉冲的P815细胞的特异裂解。

图4显示经沙眼衣原体SWIB蛋白质免疫的C57B1/6小鼠中的抗体同种型效价。

图5显示经沙眼衣原体SWIB蛋白质免疫的C3H小鼠的脾细胞中的衣原体特异性T细胞增殖应答。

图6显示根据肺炎衣原体设计的、用于从肺炎衣原体中分离SWIB和S13基因的5’和3’引物序列。

图7A和7B显示，在受到表达衣原体蛋白质的单核细胞来源的树突细胞激活后能与沙眼衣原体和肺炎衣原体发生交叉反应的人抗衣原体T细胞系(TCL-8)的IFN-γ诱导。

图8显示用T细胞系TCL 8 EB/DC对衣原体核糖体S13蛋白质中的T细胞表位的鉴定。

图9A和B说明，针对肺炎衣原体感染的树突细胞产生的CP-21 T细胞对重组肺炎衣原体-SWIB蛋白质，而非沙眼衣原体SWIB蛋白质的增殖应答。

图10显示来自无症状供体的原代T细胞系(TCT-10 EB)的沙眼衣原体特异性SWIB增殖应答。

图11说明用抗原特异性T细胞系(TCL-10 EB)对沙眼衣原体SWIB中的T细胞表位的鉴定。

图12显示由两名患者抗CT特异性抗原CT622、CT875和CT EB产生的原代T细胞系的沙眼衣原体特异性增殖应答。

发明详述

正如以上指出的，本发明一般涉及用于诊断和治疗衣原体感染的组合物和方法。一方面，本发明的组合物包括含有衣原体抗原或其变体的至少一个免疫原性部分的多肽。

在具体的实施方案中，本发明公开了包含衣原体抗原的免疫原性部分的多肽，其中所述衣原体抗原包含本文所公开的多核苷酸分子、所述核苷酸序列的互补分子及这些序列的变体所编码的氨基酸序列。

本文中，术语“多肽”包括任何长度的氨基酸链，包括全长蛋白质(即抗原)，其中氨基酸残基通过共价肽键连接在一起。因此，包含一个本发明抗原的免疫原性部分的多肽可以完全由该免疫原性部分组成，或者可以含有其它序列。所述其它序列可以来源于天然的衣原体抗原或可以是异源的，而且该序列可以(但不必须)具有免疫原性。

术语“多核苷酸”在本文中指脱氧核糖核酸或核糖核酸碱基的单链或双链聚合物，包括DNA和相应的RNA分子(包括HnRNA和mRNA分子)，既包括有义链也包括反义链，且包括cDNA、基因组DNA和重组DNA，以及完全或部分合成的多核苷酸。HnRNA分子含有内含子，并以大体一一对应的方式与DNA分子相应。mRNA分子相应于从中切除了内含子的HnRNA和DNA分子。多核苷酸可以由完整的基因或其任何部分组成。可操作的反义多核苷酸可以含有相应多核苷酸的片断，由此“多核苷酸”定义包括所有这些可操作的反义片断。

抗原的“免疫原性部分”是能够与获自衣原体感染个体的血清反应的部分(即，在本文所描述的代表性ELISA试验中，其与来自感染个体的血清产生的吸光度读数比用未感染个体的血清获得的吸光度读数高至少三个标准差)。该免疫原性部分一般包含至少约5个氨基酸残基，更优选至少约10个，最优选至少约20个氨基酸残基。用于制备和鉴定已知序列的抗原的免疫原性部分的方法是本领域已知的，包括Paul，Fundamental Immunology，第3版，Raven Press，1993，pp243-247和其中所引文献中总结的那些。这些技术包括筛选能够与抗原特异性抗体、抗血清和/或T细胞系或克隆反应的多肽。本文中，抗血清和抗体如果可以特异地与抗原结合(即，在ELISA或其它免疫试验中能与抗原蛋白质反应，但与无关蛋白质没有可检测的反应)，则它们是“抗原特异性的”。该抗血清和抗体可以按本文所述和利用熟知技术制备。天然衣原体蛋白质的免疫原性部分是与该抗血清和/或T细胞的反应水平在实质上不低于全长多肽的反应性(例如，在ELISA和/或T细胞反应性试验中)的部分。该免疫原性部分可以在这些试验中以类似或高于全长多肽的反应性的水平发生反应。该筛选一般可以使用本领域普通技术人员熟知的方法进行，例如Harlow和Lane，抗体：实验室手册(Antibodies：A laboratory Manual)(Cold SpringHarbor Laboratory，1988)中描述的那些方法。例如，可以将多肽固定在固体支持物上，使其与患者血清接触以允许血清中的抗体与固定的多肽结合。然后除去未结合的血清，并用例如¹²⁵I标记的A蛋白检测结合的抗体。

本发明考虑的抗原的免疫原性部分的实例包括，例如，SEQ ID NO9，10，18，19，31，39，93-96，98，100-102，106，108，138-140，158，167，168，246，247和254-256中提供的T细胞刺激表位。至少包含本文所述一个或多个衣原体抗原的免疫原性部分的多肽一般可以单独或联合用于检测患者中的衣原体感染。

本发明组合物和方法还包括上述多肽和多核苷酸分子的变体。该变体包括，但不限于，本发明序列的天然等位变体。具体地，变体包括与本文所述本发明多肽和多核苷酸分子有同源性的其它衣原体血清变型，例如血清变型D，E和F，以及几种LGV血清变型。优选地，该血清变型同系物(homologue)表现出与本文描述的相应多肽序列有95-99％同源性。

多肽“变体”在本文中是指仅因保守替代和/或修饰而不同于所指多肽以致保留了所指多肽的抗原性性质的多肽。在优选实施方案中，变体多肽与指明的序列相差5个或更少个氨基酸替代、缺失或插入。该变体一般可以通过使用例如本文描述的代表性方法修饰上述其中一个多肽序列，然后评价该修饰多肽的抗原性性质，而得以鉴定。换言之，相对于天然蛋白质，可以增强或不改变变体与抗原特异性抗血清的反应能力，或相对于天然蛋白质，可以将此能力减少50％以下，优选20％以下。该变体一般可以通过修饰上述其中一个多肽序列，然后评价该修饰多肽与本文描述的抗原特异性抗体或抗血清的反应性，而得以鉴定。优选的变体包括其中一个或多个部分，如N端前导序列或跨膜域已被除去的那些。其它优选变体包括其中已除去了成熟蛋白质N和/或C端的小部分(例如1-30个氨基酸，优选5-15个氨基酸)的变体。

本文中，“保守替代”是指这样的替代，其中一个氨基酸替代为具有相似性质的另一个氨基酸，以致肽化学领域的技术人员可以预期该多肽的二级结构和亲水性质基本上未发生改变。氨基酸替代一般可以根据残基在极性、电荷、溶解性、疏水性、亲水性和/或两性性质方面的相似性进行。例如，带负电荷的氨基酸包括天冬氨酸和谷氨酸；带正电荷的氨基酸包括赖氨酸和精氨酸；具有不带电荷的极性头基团的具有相似亲水性值的氨基酸包括亮氨酸、异亮氨酸和缬氨酸；甘氨酸和丙氨酸；天冬酰胺和谷氨酰胺；及丝氨酸、苏氨酸、苯丙氨酸和酪氨酸。可以表现保守改变的其它组氨基酸包括：(1)ala，pro，gly，glu，asp，gln，asn，ser，thr；(2)cys，ser，tyr，thr；(3)val，ile，leu，met，ala，phe；(4)lys，arg，his；和(5)phe，tyr，trp，his。变体还可以，或者是作为备选方案，含有非保守改变。在优选实施方案中，变体多肽与天然序列相差5个或更少个氨基酸替代、缺失或添加。变体还可以(或者是作为备选方案)通过例如缺失或添加对多肽的免疫原性、二级结构和亲水性质具有最小影响的氨基酸来修饰。变体还可以，或者是作为备选方案，含有其它修饰，包括对多肽的抗原性质、二级结构和亲水性质具有极小影响的氨基酸的缺失或添加。例如，可以使多肽在蛋白质的N末端缀合(conjugate)信号(或前导)序列，该序列将共翻译或翻译后指导该蛋白质转移。该多肽还可以和利于该多肽合成、纯化或鉴定(例如多聚His)或增强该多肽与固相支持物的结合的接头或其它序列缀合。例如，多肽可以和免疫球蛋白Fc区缀合。

多核苷酸“变体”是与所引述的核苷酸序列相差一个或多个核苷酸缺失、替代或添加以致编码的多肽的免疫原性相对于天然蛋白质而言不发生减弱的序列。对所编码多肽的免疫原性的影响一般可以按本文所述进行评价。这些修饰可以容易地通过使用标准诱变技术，例如Adelman等(DNA，2：183，1983)教导的寡核苷酸指导的位点特异性诱变来引入。核苷酸变体可以是以下讨论的天然等位变体，或非天然变体。本发明提供的多肽包括由基本上与这里具体描述的一个或多个多核苷酸序列同源的多核苷酸序列编码的变体。“基本上同源”在本文中指能够在中等严紧条件下杂交的多核苷酸序列。适宜的中等严紧条件包括在5×SSC、0.5％SDS、1.0mM EDTA(pH 8.0)的溶液中预洗涤；在50℃-65℃，5×SSC中过夜杂交，或在交叉物种同源性的情况下，在45℃使用0.5×SSC进行杂交；然后，使用含有0.1％SDS的2×、0.5×和0.2×SSC各在65℃进行2次20分钟洗涤。该杂交多核苷酸序列也在本发明的范围内，同样由于密码简并性而编码与本发明多肽相同的多肽的核苷酸序列也在本发明范围内。

如果两个核苷酸或多肽序列中的核苷酸或氨基酸残基序列在按下述为了最大对应进行比对时是相同的，则这两个序列被说成是“一致的”。两个序列进行比较的方式典型地是通过在比较窗内比较序列以鉴定和比较局部区域的序列相似性。“比较窗”在本文中是指具有至少约20个连续位置，通常30至约75个位置、40至约50个位置的区段，在该区段中一个序列与具有相同数目的连续位置的参考序列在两序列最佳比对(alignment)后可以进行比较。

为了进行比较，可以使用生物信息学软件的Lasergene软件包(DNASTAR，Inc.，Madison，WI)以及默认参数，对序列进行最佳比对。该程序体现了如下参考文献中描述的几个比对策略；Day Dayhoff，M.O.(1978)，蛋白质进化改变模型-用于检测远缘关系的矩阵，Dayhoff，M.O.(编)《蛋白质序列和结构的图谱集》(Atlas of Protein Sequenceand Structure)，National Biomedical Resarch Foundaiton，Washington D.C.Vol.5，Suppl.3，pp.345-358；Hein J.(1990)比对和系统发生的统一方法pp.626-645酶学方法(Methods inEnzymology)vol.183，Academic Press，Inc.，San Diego，Calif.；Higgins，D.G.和Sharp，P.M.(1989)在微型计算机上快速灵敏的多序列比对，CABIOS 5：151-153；Myers，E.W.和Muller W.(1988)线性空间中的最佳比对，CABIOS 4：11-17；Robinson，E.D.(1971)Comb.Theor 11：105；Santou，N.Nes，M.(1987)相邻连接方法，一种用于重建系统发生树的新方法，Mol.Biol.Evol.4：406-425；Sneath，P.H.A.和Sokal，R.R.(1973)《数值分类学--数值分类学的原理和实践》(Numerical Taxonomy-the Principles andPractice of Numerical Taxonomy)，Freeman Press，San Francisco，Calif.；Wilbur，W.J.和Lipman，D.J.(1983)核酸和蛋白质数据库的快速相似性检索，Proc.Natl.Acad.，Sci.USA 80：726-730。

或者，可以通过Smith和Waterman(1981)Add.APL.Math 2：482的局部一致性算法；Needleman和Wunsch(1970)J.Mol.Biol.48：433的一致性比对算法；Pearson和Lipman(1988)Proc.Natl.Acad.Sci.(U.S.A.)85：2444的相似性检索方法；这些算法的计算机执行程序(Wisconsin遗传学软件包中的GAP，BESTFIT，BLAST，FASTA和TFASTA，Genetics Computer Group(GCG)，575Science Dr.，Madison，WI)；或目测对进行比较的序列作最佳比对。

适于确定序列一致性和序列相似性百分数的算法的一个举例说明例子是BLAST和BLAST 2.0算法，分别描述在Altschul等(1977)Nuc.Acids Res.25；3389-3402和Altschul等(1990)J.Mol.Biol.215：403-410。例如使用这里描述的参数，可以用BLAST和BLAST 2.0确定本发明多核苷酸和多肽的序列一致性百分数。进行BLAST分析的软件可以通过生物技术信息国家中心(National Center forBiotechnology Information)(http：//www.ncbi.nlm.nih.gov/)公开获得。在一个举例说明性例子中，对于核苷酸序列，可以使用参数M(成对匹配残基的奖励分数；总＞0)和N(错配残基的罚分；总＜0)计算累积分数。对于氨基酸序列，可以使用评分矩阵计算累积分数。当：累积比对分数从其最大获得值下降量X时；累积分数因一个或多个负分残基比对而趋近于零或以下时；或达到任一个序列的末端时，终止字符配对(word hit)在各方向的延伸。BLAST算法参数W、T和X确定了比对的灵敏度和速度。BLASTN程序(用于核苷酸序列)使用11的字长(W)、10的期望值(E)和BLOSUM62评分矩阵(见Henikoff和Henikoff(1989)Proc.Natl.Acad.Sci.USA 89：10915)比对，50的期望值(B)、10的期望值(E)、M＝5、N＝4和双链比较作为默认值。

优选地，“序列一致性百分数”通过在具有至少20个位置的比较窗中比较两个最佳比对的序列来确定，其中，为了两个序列的最佳比对，与参考序列(不含有添加或缺失)相比，比较窗中的多核苷酸或氨基酸序列部分可以包含20％或更少，通常5％至15％，或10％至12％的添加或插入(即缺口)。此百分数通过确定两个序列中出现相同核酸碱基或氨基酸残基的位置数目得到匹配位置数目，然后用该匹配位置数目除以参考序列中的总位置数目(即窗的大小)并将结果乘以100，从而得到序列一致性百分数。

因此，本发明提供与本文公开的序列具有实质上的一致性的多核苷酸和多肽序列，例如使用这里公开的方法(例如，使用标准参数进行的BLAST分析，见下述)，与本发明多核苷酸或多肽序列相比，包含至少50％或更高的序列一致性，优选至少55％、60％、65％、70％、75％、80％、85％、90％、95％、96％、97％、98％或99％或更高的序列一致性的那些。本领域技术人员明了，可以通过考虑密码子简并性、氨基酸相似性、阅读框位置等，对这些值作适当调整以确定两个多核苷酸序列编码的蛋白质的相应一致性。

在其它实施方案中，本发明提供包含与本文公开的一个或多个序列一致或互补的各种长度的连续序列段的分离多核苷酸或多肽。例如，本发明所包括的多核苷酸和多肽可以包含一个或多个本发明所公开序列的至少约15、20、30、40、50、75、100、150、200、300、400、500或1000或更多个连续核苷酸，以及其间所有中间长度的连续核苷酸。容易理解的是，“中间长度”在此上下文中是指引用值之间的任何长度，例如16、17、18、19等；21、22、23等；30、31、32等；50、51、52、53等；100、101、102、103等；150、151、152、153等；包括从200至500；从500至1,000等的所有整数。

本发明多核苷酸，或其片断，无论本身编码序列的长度如何，均可以和其它DNA序列，如启动子、聚腺苷酸化信号、附加限制性酶位点、多克隆位点、其它编码区段等组合，以致其整个长度可以发生相当大的变化。因此，这里考虑使用具有几乎任何长度的核酸片断，优选根据容易在预期的重组DNA操作中进行制备和使用对总长度作限制。例如，具有总长度约10,000、约5000、约3000、约2000、约1000、约500、约200、约100、约50个碱基对的举例说明性DNA区段可以考虑用于本发明的许多实施方式中。

编码本文所述核苷酸序列的基因的等位序列也包括在本发明范围内。本文中，“等位基因”或“等位序列”是基因的备选形式，该形式可以由核酸序列中的至少一个突变引起。等位基因可以导致改变的mRNA或结构或功能可能发生改变或可能不发生改变的多肽。任何给定的基因均可以没有、有一种、或有许多种等位形式。一般可以将产生等位基因的常见突变归为核苷酸的天然缺失、添加或替代。所有这些类型的改变均可以单独地或组合其它改变在给定序列中发生一或多次。

在具体实施方案中，本发明公开了包含衣原体抗原(或该抗原的变体)的至少免疫原性部分的多肽，所述抗原包含由如下多核苷酸序列编码的一个或多个氨基酸序列：(a)选自SEQ ID NO：358-361、407-430、525-559、582-598的多核苷酸序列；(b)这些DNA序列的互补序列；或(c)与(a)或(b)中的序列实质上同源的DNA序列。如以下实施例中讨论的，几种本文公开的衣原体抗原可以识别如下T细胞系，所述T细胞系识别沙眼衣原体和肺炎衣原体感染的单核细胞来源的树突细胞，这说明这些抗原可能代表沙眼衣原体和肺炎衣原体共有的免疫反应性表位。因此，所述抗原可以在用于沙眼衣原体生殖道感染和肺炎衣原体感染的疫苗中使用。为确定交叉反应程度，对来自沙眼衣原体和肺炎衣原体的这些衣原体抗原的进一步表征描述在实施例6中。此外，实施例4描述了分离自沙眼衣原体、编码能够刺激衣原体特异性小鼠CD8+T细胞系的蛋白质(SEQ ID NO：17-19和32)的cDNA片断(SEQ ID NO：15，16和33)。

一般地，衣原体抗原和编码该抗原的多核苷酸序列可以使用多种方法中的任一种来制备。例如，编码衣原体抗原的多核苷酸分子可以通过按下述用衣原体特异性T细胞系筛选从衣原体基因组或cDNA表达文库中分离出来，并使用本领域技术人员熟知的技术测序。此外，可以按以下更为详细描述的方法通过从cDNA微阵列中筛选衣原体相关表达(即，使用这里提供的代表性试验确定时，所述表达在衣原体感染的细胞中比在对照中高至少两倍)，鉴定多核苷酸。该筛选可以使用Synteni微阵列(Palo Alto，CA)根据厂商说明书(并基本上按Schena等，Proc.Natl.Acad.Sci.USA 93：10614-10619，1996和Heller等，Proc.Natl.Acad.Sci.USA 94：2150-2155，1997描述的方法)进行。或者，可以从制备自表达本文所述蛋白质的细胞的cDNA扩增多肽。可以通过聚合酶链式反应(PCR)扩增该多核苷酸。对于此方法，序列特异性引物可以根据本文提供的序列设计，也可以购买或合成。

抗原可以按如下所述通过将编码抗原的多核苷酸序列插入表达载体中然后在适当宿主中表达该抗原以重组方式制备。可以按本文所述对抗原的期望性质，如与获自衣原体感染个体的血清反应的能力进行评价，并可以使用例如传统Edman化学对抗原进行测序。见Edman和Berg，Eur.J.Biochem.80：116-132，1967。

编码抗原的多核苷酸序列也可以通过从适当的衣原体cDNA或基因组DNA文库中筛选能与从分离抗原的部分氨基酸序列衍生的简并寡核苷酸杂交的多核苷酸序列而获得。可以按(例如)Sambrook等，Molecular Cloning：A Laboratory Manual，Cold Spring HarborLaboratories，Cold Spring Harbor，NY(及其中引用文献)描述的方法设计并合成用于该筛选中的简并核苷酸序列，并进行该筛选。还可以使用聚合酶链式反应(PCR)，用上述寡核苷酸在本领域熟知方法中从cDNA或基因组文库分离核酸探针。然后使用分离的探针筛选文库。

可以使用扩增部分利用熟知技术从适宜的文库(例如衣原体cDNA文库)中分离全长基因。在这些技术中，可以使用一个或多个多核苷酸探针或适于扩增的引物筛选文库(cDNA或基因组)。优选按大小筛选文库以包括较大分子。也可以优选使用随机引发文库(random primedlibrary)鉴定基因的5’和上游区域。优选使用基因组文库获得内含子和延伸的5’序列。

对于杂交技术，可以使用熟知技术标记部分序列(例如通过切口平移或用32P进行末端标记)。然后通过标记探针与含有变性的细菌菌落(或含有噬菌斑的菌苔)的滤膜杂交，筛选细菌或噬菌体文库(见Sambrook等，Molecular Cloning：A Laboratory Manual，ColdSpring Harbor Laboratories，Cold Spring Harbor，NY，1989)。选择发生杂交的菌落或噬菌斑，并分离DNA用于进一步分析。可以分析cDNA克隆以确定其它序列的量，例如通过PCR使用来自该部分序列的引物和来自载体的引物进行分析。可以制备限制性图谱和部分序列以鉴定出一个或多个重叠克隆。然后，可以使用标准技术(这可涉及产生一系列缺失克隆)确定完整序列。之后将获得的重叠序列组装成一个连续的序列。全长cDNA分子可以使用熟知技术通过连接适宜片断来产生。

或者，有许多扩增技术可以用于从部分cDNA序列获得全长编码序列。在这些技术中，一般通过PCR进行扩增。可以使用多种商业试剂盒中的任一种实施扩增步骤。引物可以使用本领域熟知技术设计(见，例如Mullis等，Cold Spring Harbor Symp.Quant.Biol.51：263，1987；Erlich编，PCR技术(PCR Technology)，Stockton Press，NY，1989)，也可以使用本领域熟知的软件。引物优选长22-30个核苷酸，具有至少50％的GC含量，而且可以在约68℃至72℃的温度下与靶序列退火。扩增的区域可以按上述方式测序，然后可以将重叠序列组装成一个连续序列。

一个这样的扩增技术是反向PCR(见Triglia等，Nucl.Acids Res.16：8186，1988)，该技术使用限制性酶在基因的已知区域中产生一个片段。然后通过分子内连接使该片段环化，将其用作PCR的模板，使用来自该已知区域背驰引物进行扩增。在另一备选方法中，可以通过使用针对接头序列的引物和对已知区域具有特异性的引物进行扩增，获得与部分序列相邻的序列。典型地使用相同接头引物和对该已知区域具有特异性的第二引物对该扩增序列进行第二轮扩增。该方法的变体使用以相反方向从已知序列起始延伸的两个引物，见WO 96/38591。其它技术包括捕获PCR(Lagerstrom等，PCR Methods Applic.1：111-19，1991)和步行PCR(Parker等，Nucl.Acids.Res.19：3055-60，1991)。转录介导的扩增或TMA是可以用于扩增DNA、rRNA或mRNA的另一方法，描述在专利PCT/US91/03184中。此非PCR为基础的自动催化恒温方法利用两个引物和两个酶：RNA聚合酶和逆转录酶。一个引物含有RNA聚合酶的启动子序列。在第一次扩增中，启动子引物与靶rRNA在确定位点杂交。逆转录酶通过从该启动子引物的3’末端进行延伸，产生靶rRNA的DNA拷贝。降解所获复合物中的RNA，并且第二引物和该DNA拷贝结合。逆转录酶从该引物末端合成一条新DNA链，从而产生双链DNA。RNA聚合酶识别该DNA模板中的启动子序列并起始转录。每一个新合成的RNA扩增子都重新进入该TMA程序并充当新一轮复制的模板，从而导致该RNA扩增子的指数扩增。还可以使用其它利用扩增实施的方法来获得全长cDNA序列。

在某些情况下，可以通过分析已表达序列标志(EST)数据库(例如可从GenBank获得)中提供的序列获得全长cDNA序列。一般可以使用熟知程序(例如，NCBI BLAST检索)查找重叠EST，然后可以利用这些EST产生连续的全长序列。还可以通过分析基因组片段获得全长cDNA序列。

多核苷酸变体一般可以通过本领域已知的任何方法制备，这些方法包括化学合成，例如固相亚磷酰胺化学合成。还可以使用标准诱变技术，如寡核苷酸指导的位点特异性诱变(见Adelman等，DNA 2：183，1983)，在多核苷酸序列中引入修饰。或者，可以通过体外或体内转录编码衣原体蛋白质或其部分的DNA序列，制备RNA分子，前提是将该DNA插入具有适宜RNA聚合酶启动子(例如T7或SP6)的载体中。某些部分可以用于制备编码的多肽，如本文所述。此外，或者作为可选择方案，可以给患者施用某部分，以便体内产生编码的多肽(例如用编码衣原体多肽的cDNA构建体转染抗原呈递细胞，如树突细胞，然后给患者施用该转染的细胞)。

与编码序列互补的序列部分(即反义多核苷酸)也可以用作探针或用于调节基因表达。还可以将能够转录为反义RNA的cDNA构建体导入组织细胞中以便于产生反义RNA。如本文所述，可以使用反义多核苷酸抑制衣原体蛋白质表达。可以使用反义技术通过形成三股螺旋破坏双螺旋打开足够大以结合聚合酶、转录因子或调节分子的能力来控制基因表达(见Gee等，Molecular and Immunologic Approaches(Huber和Carr编)，Futura Publishing Co.(Mt.Kisco，N.Y.；1994))。或者，可以设计反义分子以和基因的控制区域(例如启动子、增强子或转录起始位点)杂交，由此阻断基因转录；或通过抑制转录本和核糖体的结合阻断翻译。

还可以将编码序列或互补序列的一部分设计为探针或引物检测基因表达。探针可以用多种报道基团，如放射性核素和酶标记，并优选长至少10个核苷酸、更优选至少20个核苷酸、甚至更优选至少30个核苷酸。如上述，引物优选长22-30个核苷酸。

任何多核苷酸均可以进一步修饰以增加体内稳定性。可能的修饰包括，但不限于，在5’和/或3’末端添加侧翼序列；在主链中使用硫代磷酸或2’0-甲基而非磷酸二酯键；和/或包括非传统碱基，如肌苷、queosine和wybutosine以及腺嘌呤、胞嘧啶、鸟嘌呤、胸腺嘧啶和尿嘧啶的乙酰基、甲基、硫代修饰形式及其它修饰形式。

本文所述核苷酸序列可以和多种其它核苷酸序列通过成熟的重组DNA技术连接在一起。例如，可以将多核苷酸克隆在多种克隆载体(包括质粒、噬菌粒、λ噬菌体衍生物和粘粒)之任一种中。尤其有意义的载体包括表达载体、复制载体、探针制备载体和测序载体。一般地，载体含有在至少一种生物中有功能的复制起点、方便的限制性内切酶位点和一个或多个选择标记。其它元件取决于所期望的应用，它们对于本领域普通技术人员是明显的。

具有少于约100个氨基酸、一般少于约50个氨基酸的合成多肽可以使用本领域熟知技术产生。例如，可以使用任何一种商业固相技术，如Merrifield固相合成方法(其中氨基酸被顺序地添加到生长的氨基酸链上)合成此类多肽。见Merrifield，J.Am.Chem.Soc.85：2149-2146，1963。自动合成多肽的仪器可从供应商如PerkinElmer/Applied BioSystems Division(Foster City，Calif)商购获得，并可以根据厂商说明书操作。

如上所述，衣原体抗原的免疫原性部分可以使用熟知技术，如总结在Paul，Fundamental Immunology，第3版，Raven Press，1993，pp.243-247及其中的引用文献中的那些技术进行制备和鉴定。这些技术包括筛选具有免疫原性质的天然抗原的多肽部分。在这些筛选中一般可以使用本文描述的代表性ELISA。多肽的免疫原性部分是在这些代表性试验中能和全长抗原产生基本相似水平的信号的部分。换言之，在本文描述的模式ELISA中，衣原体抗原的免疫原性部分产生的信号是全长抗原诱导的信号的至少约20％，优选约100％。

衣原体抗原的部分和其它变体可以通过合成或重组方式制备。天然抗原的变体一般可以使用标准诱变技术，如寡核苷酸指导的位点特异性诱变来制备。还可以使用允许制备截短多肽的标准技术除去多核苷酸序列的一些节段。

含有天然抗原的部分和/或变体的重组多肽可以容易地从编码该多肽的多核苷酸使用本领域普通技术人员熟知的多种技术制备。例如，可以首先使用商业滤器浓缩来自将重组蛋白分泌至培养基的适当宿主/载体系统的上清液。浓缩后，可以将浓缩液加载至适宜纯化基质如亲和基质或离子交换树脂上。最后，可以使用一个或多个反向HPLC步骤进一步纯化重组蛋白。

本领域普通技术人员已知的多种表达载体均可以用于表达本文所述的重组多肽。表达可以在已转化或转染了含有编码重组多肽的多核苷酸分子的表达载体的适当宿主细胞中实现。适宜的宿主细胞包括原核细胞、酵母或哺乳动物细胞系，例如COS或CHO。以此方式表达的DNA序列可以编码天然抗原、天然抗原的部分、或它的其它变体。

一般地，无论使用何种制备方法，本文公开的多肽均可以以分离的、基本上纯的形式制备得到。优选地，多肽具有至少约80％纯度、更优选至少约90％纯度、最优选至少约99％纯度。

在某些具体实施方案中，多肽可以是包含本文所述多个多肽的融合蛋白质，或是包含至少一个本文所述多肽和无关序列(例如已知的衣原体蛋白质)的融合蛋白。融合伙伴可以例如帮助提供T辅助细胞表位(Thelper epitopes)(免疫学融合伙伴)，优选可以被人识别的T辅助细胞表位，或可以帮助该蛋白质以更高的产率(与原来的重组蛋白质相比而言)表达(表达增强子)。某些优选的融合伙伴既是免疫学融合伙伴又是表达增强融合伙伴。可以选择其它融合伙伴以增加蛋白质的溶解度或使该蛋白质能够靶向期望的细胞内区室。再其它融合伙伴包括利于蛋白质纯化的亲和标签。编码本发明融合蛋白的DNA序列可以使用已知的重组DNA技术将编码例如第一和第二多肽的分离DNA序列组装在一个适当的表达载体中而得以构建。使编码第一多肽的DNA序列的3’末端和编码第二多肽的DNA序列的5’末端在有或无肽接头的情况下连接，以便这些序列的阅读框可以同相以允许两个DNA序列翻译为保留了第一和第二多肽的生物学活性的单一融合蛋白质。

可以使用肽接头将第一和第二多肽分开足够大的距离以确保每个多肽都折叠成其二级结构和三级结构。该肽接头序列可以使用本领域熟知的标准技术并入融合蛋白中。可以基于如下因素选择适宜的肽接头序列：(1)其能够采取柔性伸展构象；(2)其不能采取会与第一和第二多肽上的功能性表位相互作用的二级结构；和(3)缺少可以和这些多肽功能性表位反应的疏水或带电荷残基。优选的肽接头序列含有Gly，Asn和Ser残基。其它仅中性氨基酸，如Thr和Ala也可以用于该接头序列中。通常可以用作接头的氨基酸序列包括公开在Maratea等，Gene 40：39-46，1985；Murphy等，Proc.Natl.Acad.Sci.USA83：8258-8562，1986；U.S.专利4,935,233和4,751,180中的那些。接头序列可以长1至约50个氨基酸。作为使用肽接头序列的替换方法(如果期望的话)，可以利用第一和第二多肽上非必需的N端氨基酸区域(如果存在的话)分离功能域和预防空间位阻。

将这些连接的DNA序列可操作地和适宜的转录或翻译调节元件连接。负责DNA表达的调节元件仅位于编码第一多肽的DNA序列的5’。类似地，终止翻译所需的终止密码子和转录终止信号仅存在于编码第二多肽的DNA序列的3’。

本发明还提供包含本发明多肽和无关免疫原性蛋白质的融合蛋白。优选地，该免疫原性蛋白质能够引起回忆应答。这类蛋白质的实例包括破伤风、肺结核和肝炎蛋白质(见例如Stoute等New Engl.J.Med.，336：86-91，1997)。

在优选实施方案中，免疫学融合伙伴来源于D蛋白，一种革兰氏阴性细菌嗜血流感菌B(Haemophilus influenza B)的表面蛋白质(wo91/18926)。优选地，D蛋白衍生物包含该蛋白的大约头三分之一(例如，N端头100-110个氨基酸)，而且D蛋白衍生物可以是脂化的。在某些优选实施方案中，脂蛋白D融合伙伴的头109个残基被包括在N端上以给该多肽提供额外的外源T细胞表位和增强在大肠杆菌(E.coli)中的表达(由此起到表达增强子的作用)。脂质尾部确保抗原向抗原呈递细胞的最佳呈递。其它融合伙伴包括来自流感病毒的非结构蛋白质，NS1(血凝素)。典型地，使用N端81个氨基酸，但也可以使用包括T辅助细胞表位的不同片段。

在另一实施方案中，免疫学融合伙伴是称作LYTA的蛋白质，或其部分(优选C端部分)。LYTA来源于肺炎链球菌，其合成称作酰胺酶LYTA的N-乙酰基-L-丙氨酸酰胺酶(由LytA基因编码；Gene43：265-292，1986)。LYTA是特异降解肽聚糖主链中的某些键的自溶素。LYTA蛋白质的C段域负责和胆碱或一些胆碱类似物如DEAE亲和。该性质已被利用于开发大肠杆菌C-LYTA表达质粒，用于表达融合蛋白。在氨基端含有C-LYTA片段的杂合蛋白的纯化已有描述(见Biotechnology 10：795-798，1992)。在优选实施方案中，可以将LYTA的重复部分并入融合蛋白中。在该C段区域中从第178位残基开始存在一个重复部分。尤其优选的重复部分含有第188-305位残基。

在另一实施方案中，来源于结核分枝杆菌(Mycobacteriumtuberculosis)的Ra12多核苷酸与本发明多核苷酸的至少免疫原性部分连接。Ra12组合物和其用于增强异源多核苷酸序列表达的方法描述在U.S.专利申请60/158,585，该文献的公开文本完整地并入本文作为参考。简而言之，Ra12是指这样一个多核苷酸区域，该区域是结核分枝杆菌MTB32A核酸的亚序列。MTB32A是一个分子量32kD的丝氨酸蛋白酶，由结核分枝杆菌的强毒株和无毒株中的一个基因编码。MTB32A的此核苷酸序列和氨基酸序列已有描述(U.S.专利申请60/158,585；也见，Skeiky等，Infection and Immun.(1999)67：3998-4007，并入本文作为参考)。在一个实施方案中，用于制备融合多肽的Ra12多肽包含该MTB32A编码序列的如下C端片段，该片段可以有效地增强与其融合的异源衣原体抗原多肽的表达和/或免疫原性。在另一实施方案中，Ra12多肽相应于MTB32A的大约14kD C端片段，其中包含MTB32A第192至323位氨基酸残基中的一些或全部。

编码包含Ra12多肽和目的异源衣原体多肽的融合多肽的重组核酸可以容易地使用常规遗传工程技术构建。构建重组核酸，以便优选地Ra12多核苷酸序列位于所选异源衣原体多核苷酸序列的5’。将Ra12多核苷酸序列置于所选异源多核苷酸序列的3’可能也是适当的，或在Ra12多核苷酸序列内部的一个位置上插入异源多核苷酸序列。

此外，编码Ra12或其部分或其它变体的任何适宜多核苷酸均可以用于构建包含Ra12和一个或多个本文所述衣原体多核苷酸的重组融合多核苷酸。优选的Ra12多核苷酸一般包含编码Ra12多肽一部分的至少大约15个连续多核苷酸、至少约30个核苷酸、至少约60个核苷酸、至少约100个核苷酸、至少约200个核苷酸或至少约300个核苷酸。

Ra12多核苷酸可以包含天然序列(即编码Ra12多肽或其部分的内源性序列)或可以包含该序列的变体。Ra12多核苷酸变体可以含有一个或多个替代、添加、缺失和/或插入，以致该编码的融合多肽的生物学活性相对于包含天然Ra12多肽的融合多肽的生物学活性而言基本上没有减弱。变体优选表现出与编码天然Ra12多肽或其部分的多核苷酸序列有至少约70％一致性、更优选至少约80％一致性、最优选至少约90％一致性。

另一方面，本发明提供使用一个或多个以上多肽或融合蛋白(或编码这些多肽或融合蛋白的多核苷酸)在患者体内诱导抗衣原体感染的保护性免疫的方法。本文中，“患者”是指任何恒温动物，优选人。患者可以患有疾病，或可以不存在可检测的疾病和/或感染。换言之，可以诱导保护性免疫以预防或治疗衣原体感染。

在此方面，多肽、融合蛋白或多核苷酸分子一般存在于药物组合物或疫苗中。药物组合物可以包含一个或多个多肽(每个均可以含有一个或多个以上序列(或其变体))以及生理可接受载体。疫苗可以包含一个或多个以上多肽和免疫刺激剂，如佐剂或脂质体(其中包含该多肽)。这些药物组合物和疫苗还可以含有其它衣原体抗原，它们可以并入组合多肽中或可以存在于单独的多肽中。

或者，疫苗可以含有编码上述一个或多个多肽或融合蛋白的多核苷酸，以便可以原位产生该多肽。在此类疫苗中，多核苷酸可以存在于本领域普通技术人员已知的多种递送系统中的任一种中，这些递送系统包括核酸表达系统、细菌和病毒表达系统。适当的核酸表达系统含有在患者中进行表达所必需的多核苷酸(例如适宜的启动子和终止信号)。细菌递送系统涉及施用细胞表面上表达所述多肽的免疫原性部分的细菌(如卡介苗)。在优选实施方案中，可以使用病毒表达系统(例如痘苗病毒或其它痘病毒、逆转录病毒或腺病毒)引入多核苷酸，这可以涉及使用非致病性(缺陷型)病毒。将多核苷酸并入这些表达系统中的技术是本领域普通技术人员熟知的。还可以以“祼”质粒载体的形式施用这些多核苷酸，参见例如Ulmer等，Science259：1745-1749，1993和Cohen，Science 259：1691-1692，1993的综述。用于将DNA并入这些载体中的技术是本领域普通技术人员熟知的。此外，逆转录病毒可以转移或并入编码选择标记(以帮助鉴定或筛选已转导的细胞)和/或靶向部分的基因，例如编码特异靶细胞上的受体的配体的基因以赋予该载体靶向特异性。还可以使用抗体，通过本领域普通技术人员已知的方法实现靶向。

用于治疗目的的其它制剂包括胶体分散系统，例如高分子复合物、纳米囊、微球、小珠和基于脂质的系统(包括水包油型乳剂)、微胶粒、混合的微胶粒和脂质体。体外和体内用作递送载体的优选胶体系统是脂质体(即人工膜小泡)。可以通过将多核苷酸加在可被有效地运输至细胞中的生物可降解小珠之中和/或之上，增加裸多核苷酸的摄取。此类系统的制备和使用是本领域熟知的。

在一个相关方面，上述多核苷酸疫苗可以和本发明多肽或已知的衣原体抗原同时或相继施用。例如，可以施用编码本发明多肽的多核苷酸(“祼露的”或在上述递送系统中)，然后再施用抗原以增强疫苗的保护性免疫效果。

本文公开的多肽和多核苷酸也可以用于过继免疫治疗中以治疗衣原体感染。过继免疫治疗可以泛泛地划分为主动或被动免疫治疗。在主动免疫治疗中，治疗依赖于通过施用免疫应答修饰剂(例如疫苗、细菌佐剂和/或细胞因子)体内刺激内源性宿主免疫系统。

在被动免疫治疗中，治疗涉及递送具有确定的免疫反应性的生物学试剂(例如效应细胞或抗体)，它们可以直接或间接地介导抗衣原体效应而不必依赖完整的宿主免疫系统。效应细胞的实例包括T淋巴细胞(例如，CD8+细胞毒T淋巴细胞、CD4+T辅助细胞)、杀伤细胞(例如天然杀伤细胞、淋巴因子激活的杀伤细胞)、B细胞或表达所公开抗原的抗原呈递细胞(例如树突细胞和巨噬细胞)。本文公开的多肽还可以用于制备抗体或抗独特型抗体(如U.S.专利4,918,164)用于被动免疫治疗。

得到过继免疫治疗所需足够数量的T细胞的主要方法是体外培养免疫T细胞。用于将单个抗原特异性T细胞的数量扩增至几十亿并保持体内抗原识别的培养条件是本领域熟知的。这些体外培养条件典型地采用以抗原进行间歇刺激，且常在存在细胞因子如IL-2和非分裂的饲喂细胞时进行。如上所述，可以使用本文描述的免疫反应性多肽快速扩增抗原特异性T细胞培养物以便产生足够用于免疫治疗的细胞数目。具体地，可以使用多种本领域熟知的标准技术，用免疫反应性多肽脉冲抗原呈递细胞如树突细胞、巨噬细胞、单核细胞、成纤维细胞或B细胞，或者将多核苷酸序列引入抗原呈递细胞中。例如，可以用多核苷酸序列转染或转导抗原呈递细胞，其中所述序列含有适用于增强表达的启动子区域并能够作为重组病毒或其它表达系统的一部分表达。可以使用几种病毒载体转导抗原呈递细胞，包括痘病毒、痘苗病毒和腺病毒；也可以用本文公开的多核苷酸序列转染抗原呈递细胞，其中实施转染的手段有多种，包括基因枪技术、脂质介导的递送、电穿孔、渗透压休克和颗粒递送机制，从而导致按本领域普通技术人员确定的有效和可接受的表达水平。为了使培养的T细胞在治疗中有效，该培养T细胞必须能够在体内生长和广泛分布以及长期存活。研究证明，使用补加了IL-2的抗原进行反复刺激可以诱导培养的T细胞在体内生长并以相当大的数量长期存活(见例如，Cheever，M.等，″用培养的T细胞进行治疗：重访原理，″Immunological Reviews，157：177，1997)。

本文公开的多肽还可以用于制备和/或分离衣原体反应性T细胞，然后可以给患者施用这些T细胞。在一项技术中，可以通过用相应于所公开多肽的免疫原性部分的短肽进行体内免疫，制备抗原特异性T细胞系。可以从患者体内分离出产生的抗原特异性CD8+或CD4+T细胞克隆，使用标准组织培养技术进行扩增，然后将它们返回患者体内。

或者，可以使用相应于这些多肽的免疫原性部分的肽，通过自体T细胞的体外选择性刺激和扩增制备衣原体反应性T细胞亚群，提供随后可以转移至患者体内的抗原特异性T细胞，参见例如Chang等(Crit.Rev.Oncol.Hematol.，22(3)，213，1996)。免疫系统的细胞，例如T细胞，可以使用商业细胞分离系统(例如Isolex(TM)System，可获自Nexell Therapeutics，Inc.Irvine，Calif)从患者的外周血中分离。使用包含在递送载体如微球中的一种或多种免疫反应性多肽刺激分离的细胞，以提供抗原特异性T细胞。然后使用标准技术扩增抗原特异性T细胞群，并将细胞重新施用回患者体内。

在其它实施方案中，可以将对本文多肽具有特异性的T细胞和/或抗体受体进行克隆、扩增，并将其转移至其它载体或效应细胞中用于过继免疫治疗。尤其是，可以用适当基因转染T细胞，以将来自衣原体特异性单克隆抗体的可变区表达为细胞外识别元件并与T细胞受体信号链连接，从而导致T细胞活化、特异裂解和细胞因子释放。这使得T细胞能够以独立于MHC的方式重新指导其特异性。见例如，Eshhar，Z.，Cancer Immunol Immunother，45(3-4)：131-6，1997和Hwu，P.，等，Cancer Res，55(15)：3369-73，1995。另一实施方案可以包括将衣原体抗原特异性α和βT细胞受体链转染至别的T细胞中，参见Cole，D J，等，Cancer Res，55(4)：748-52，1995。

在再一实施方案中，可以用相应于本文所公开多肽的至少免疫原性部分的肽脉冲同基因的或自体的树突细胞。可以将所获抗原特异性树突细胞转移至患者体内，或用于刺激T细胞以提供抗原特异性T细胞，再可以将这些T细胞施用给患者。在小鼠模型中，肽脉冲的树突细胞在制备抗原特异性T细胞中的用途以及这些抗原特异性T细胞随后在根除疾病中的用途已被Cheever等(Immunological Reviews，157：177，1997)证明。此外，可以将表达所公开多核苷酸的载体引入取自患者的干细胞中，体外克隆增殖后用于自体移植回相同患者体内。

某些方面，可以将本文公开的多肽、多核苷酸、T细胞和/或结合剂并入药物组合物或免疫原性组合物(即疫苗)中。或者，药物组合物可以包含被衣原体多核苷酸转染以致表达衣原体多肽的抗原呈递细胞(例如树突细胞)。药物组合物可以包含一种或多种此类化合物及生理可接受载体。疫苗可以包含一种或多种此类化合物及免疫刺激剂。免疫刺激剂可以是能增强或强化针对外源抗原的免疫应答的任何物质。免疫刺激剂的实例包括佐剂、生物可降解微球(例如乳酸-羟基乙酸共聚物(polylactic galactide))和脂质体(其中含有所述化合物；见例如，Fullerton，U.S.专利4,235,877)。疫苗制剂一般可参见例如M.F.Powell和M.J.Newman，编，″Vaccine Design(thesubunit and adjuvant approach)，″Plenum Press(NY，1995)。本发明范围内的药物组合物和疫苗还可以含有其它化合物，这些化合物可以是生物学活性的或无活性的。例如，该组合物或疫苗中可以以整合在融合多肽中的形式或以单独的化合物形式存在其它衣原体抗原的一个或多个免疫原性部分。

药物组合物或疫苗可以含有编码上述一个或多个多肽的DNA，以便该多肽可以原位产生。如上所述，该DNA可以存在于本领域普通技术人员已知的多种递送系统之任一种中，包括核酸表达系统、细菌和病毒表达系统。许多基因递送技术是本领域熟知的，例如可参见Rolland，Crit.Rev.Therap.Drug Carrier Systems 15：143-198，1998及其中引用的文献。适当的核酸表达系统含有在患者中进行表达所必须的DNA序列(例如适宜的启动子和终止信号)。细菌递送系统涉及施用在其细胞表面表达该多肽的免疫原性部分或分泌该表位的细菌(如卡介苗)。

在优选实施方案中，可以使用病毒表达系统(例如痘苗或其它痘病毒、逆转录病毒、腺病毒、杆状病毒、披膜病毒、噬菌体等)导入DNA，所述表达系统常涉及使用非致病性(缺陷型)具有复制能力的病毒。

例如，许多病毒表达载体来源于逆转录病毒科的病毒。该科包括鼠白血病病毒、鼠乳腺癌病毒、人泡沫病毒、劳斯肉瘤病毒和免疫缺陷病毒，包括人、猿和猫科动物的免疫缺陷病毒。在设计逆转录表达载体时的考虑因素讨论在Comstock等(1997)。

Kim等(1998)开发了优良的以鼠白血病病毒(MLV)为基础的病毒表达载体。在构建MLV载体时，Kim等发现，完整的gag序列加上紧邻上游区域都可以缺失而不会显著影响病毒的包装或基因表达。而且，发现，几乎所有U3区域都可以用人巨细胞病毒的立即早期启动子替代，而不会有有害影响。此外，还可以加入MCR和内部核糖体进入位点(IRES)，而不会有不利影响。基于他们的观察，Kim等设计了一系列包含上述一个或多个特征的以MLV为基础的表达载体。

随着对人泡沫病毒(HFV)的更多认识，发现了HFV中有利于其用作表达载体的特征。这些特征包括pol通过拼接表达以及翻译起始于确定的起始密码子。HIF病毒表达载体的其它方面参见Bodem等(1997)的综述。

Murakami等(1997)描述了劳斯肉瘤病毒(RSV)为基础的可复制禽逆转录病毒载体，IR1和IR2，可以以高水平表达异源基因。在这些载体中，将来源于脑心肌炎病毒(EMCV)的IRES插在env基因和异源基因之间。IR1保留了拼接受体位点，其存在于env基因的下游，而IR2载体缺少该位点。Murakami等证实这些载体可以高水平表达几种不同的异源基因。

近来，开发了许多慢病毒为基础的逆转录病毒表达载体。Kafri等(1997)证实，基于人免疫缺陷病毒(HIV)的表达载体可以持久表达直接递送至肝脏和肌肉中的基因。这种系统的一个优点是HIV固有的转导非分裂细胞的能力。由于Kafri等的病毒是具有水泡性口炎病毒G糖蛋白(VSVG)的假型病毒，因此它们可以转导广谱组织和细胞类型。

巨大数量的基于腺病毒的表达载体已被开发出来，这主要是由这些载体在基因治疗应用中提供的优点导致的。腺病毒表达载体和使用这些载体的方法是大量美国专利(包括美国专利5,698,202，美国专利5,616,326，美国专利5,585,362，和美国专利5,518,913，所有文献均并入本文作为参考)的主题。

其它的腺病毒结构描述在Khatri等(1997)和Tomanin等(1997)。Khatri等描述了新的绵羊腺病毒表达载体和它们感染牛鼻陀螺状胞和兔肾细胞以及一系列人细胞类型(包括肺和包皮成纤维细胞以及肝、前列腺、乳腺、结肠和视网膜细胞系)的能力。Tomanin等描述了含有T7RNA聚合酶基因的腺病毒表达载体。当引入含有可操作地连接T7启动子的异源基因的细胞中后，载体能够从T7启动子驱动基因表达。作者提出，该系统可以用于克隆和表达编码细胞毒性蛋白质的基因。

痘病毒广泛地被用于在哺乳动物细胞中表达异源基因。多年来，该载体经改善能允许高表达异源基因和简化将多个异源基因整合入单个分子中的过程。在消除致细胞病变作用和增加安全性的努力中，痘苗病毒突变体和在哺乳动物细胞中进行流产性感染的其它痘病毒正受到特殊的关注(Oertli等，1997)。痘病毒作为表达载体的用途参见Carroll和Moss(1997)的综述。

披膜病毒表达载体包括甲病毒表达载体，已被用于研究蛋白质的结构和功能和用于蛋白质生产目的。披膜病毒表达载体所具有的吸引人特征是快速而有效的基因表达、宽宿主范围和RNA基因组(Huang，1996)。而且，基于甲病毒表达载体的重组疫苗已被证实可以诱导强体液和细胞免疫应答，并具有良好的免疫记忆和保护性作用(Tubulekas等，1997)。甲病毒表达载体和其用途的讨论见例如Lundstrom(1997)。

在一个研究中，Li和Garoff(1996)使用Semliki Forest病毒(SFV)表达载体在BHK-21细胞中表达逆转录病毒基因和制备逆转录病毒颗粒。通过此方法制备的颗粒具有蛋白酶和逆转录酶活性并具有感染性。而且，在病毒原液中不能检测到辅助病毒。因此，该系统具有有利于其用于基因治疗操作的特征。

杆状病毒表达载体传统上被用于在昆虫细胞中表达异源蛋白质。蛋白质的实例包括哺乳动物趋化因子受体(Wang等，1997)、报道蛋白如绿色荧光蛋白(Wu等，1997)和FLAG融合蛋白(Wu等，1997；Koh等，1997)。近来在杆状病毒表达载体技术方面的进展，包括其在病毒粒展示载体中的应用和在哺乳动物细胞中的表达，可参见Possee(1997)的综述。其它有关杆状病毒表达载体的综述包括Jones和Morikawa(1996)和O’Reilly(1997)。

其它适宜的病毒表达系统公开在，例如，Fisher-Hoch等，Proc.Natl.Acad.Sci.USA 86：317-321，1989；Flexner等，Ann.N.Y.Acad.Sci.569：86-103，1989；Flexner等，Vaccine 8：17-21，1990；U.S.专利4,603,112，4,769,330，和5,017,487；WO 89/01973；U.S.专利4,777,127；GB 2,200,651；EP 0,345,242；WO 91/02805；Berkner，Biotechniques 6：616-627，1988；Rosenfeld等，Science252：431-434，1991；Kolls等，Proc.Natl.Acad.Sci.USA91：215-219，1994；Kass-Eisler等，Proc.Natl.Acad.Sci.USA90：11498-11502，1993；Guzman等，Circulation 88：2838-2848，1993；和Guzman等，Cir.Res.73：1202-1207，1993。用于将DNA并入这些表达载体中的技术是本领域普通技术人员熟知的。在其它系统中，该DNA可以以“祼”DNA的形式引入，参见例如Ulmer等，Science 259：1745-1749，1993和Cohen，Science 259：1691-1692，1993的综述。可以通过将DNA包被在能有效地被运输至细胞中的生物可降解小珠上，增加对裸DNA的摄取。

明显地，如果期望的话，疫苗可以包括多核苷酸和/或多肽成分。同样明显地，疫苗可含有这里所提供的多核苷酸和/或多肽的可药用盐。这些盐可以从可药用非毒性碱(包括有机碱(如伯、仲、叔胺的盐和碱性氨基酸的盐)和无机碱(例如钠、钾、锂、铵、钙和镁盐))制备。尽管本领域普通技术人员已知的任何适宜载体均可以用于本发明药物组合物中，但载体的类型将随给药方式的改变而改变。可以对本发明组合物进行配制以适应任何适当的给药方式，包括例如局部、口服、鼻、静脉内、颅内、腹膜内、皮下或肌内给药。对于肠胃外给药，例如皮下注射，载体优选包含水、盐水、醇、脂肪、蜡或缓冲液。对于口服给药，可以使用以上任一种载体或固体载体，如甘露糖醇、乳糖、淀粉、硬脂酸镁、糖精钠、滑石、纤维素、葡萄糖、蔗糖和碳酸镁。也可以使用生物可降解微球(例如polylactate polyglycolate)作为本发明药物组合物的载体。适宜的生物可降解微球公开在例如美国专利4,897,268和5,075,109。

这些组合物也可以包含缓冲液(例如，中性缓冲盐溶液或磷酸缓冲盐溶液)、糖(例如，葡萄糖、甘露糖、蔗糖或葡聚糖)、甘露醇、蛋白质、多肽或氨基酸如甘氨酸、抗氧化剂、抑菌剂、螯合剂如EDTA或谷胱苷肽、佐剂(例如氢氧化铝)、使制剂和受体血液相比等渗、低渗或微高渗的溶质、悬浮剂、增稠剂和/或防腐剂。或者，可以将本发明组合物配制成冻干物。还可以利用熟知技术将化合物包封在脂质体中。

在本发明疫苗中可以使用多种免疫刺激剂之任一种。例如，可以将佐剂包括在内。大多数佐剂含有设计以保护抗原不被快速代谢的物质，如氢氧化铝或矿物油，和免疫应答的刺激剂，例如脂质A、Bortadella pertussis或结核分枝杆菌衍生的蛋白质。适宜的佐剂可商业购买获得，例如弗氏不完全佐剂和完全佐剂(Difco Laboratories，Detroit，Mich.)；Merck佐剂65(Merck and Company，Inc.，Rahway，N.J.)；AS-2(SmithKline Beecham，Philadelphia，Pa.)；铝盐如氢氧化铝凝胶(明矾)或磷酸铝；钙、铁或锌盐；酰化酪氨酸的不溶性悬浮液；酰化糖；阳离子或阴离子衍生化的多糖；聚磷腈；生物可降解微球；单磷酰脂A和quil A。细胞因子，如GM-CSF或白介素-2、-7或-12，也可以用作佐剂。

在本文提供的疫苗中，在选择条件下，可以对佐剂组合物进行设计以诱导主要是Th1型或Th2型的免疫应答。高水平的Th1型细胞因子(如IFN-γ、TNFα、IL-2和IL-12)倾向于促进诱导细胞介导的针对施用抗原的免疫应答。相反，高水平的Th2型细胞因子(例如，IL-4，IL-5，IL-6和IL-10)倾向于促进诱导体液免疫应答。在应用本文提供的疫苗后，患者将支持包括Th1和Th2型应答在内的免疫应答。在优选实施方案中，当应答主要是Th1型的，则Th1型细胞因子水平增加的程度将比Th2型细胞因子水平增加的程度高。这些细胞因子的水平可以容易地使用标准试验评价。对于细胞因子家族的综述，见Mosmann和Coffman，Ann.Rev.Immunol.7：145-173，1989。

用于引起Th1型为主的应答的优选佐剂包括，例如，单磷酰脂A(优选3-脱-O-酰化的单磷酰脂A(3D-MPL))和铝盐的组合。MPL佐剂可从Corixa公司获得(Seattle，Wash.；见U.S.Pat.Nos.4,436,727；4,877,611；4,866,034和4,912,094)。含有CpG的寡核苷酸(其中CpG二核苷酸是未甲基化的)也诱导Th1型为主的应答。这些寡核苷酸是熟知的，描述在例如WO 96/02555和WO 99/33488。免疫刺激性DNA序列也已有描述，例如可参见Sato等，Science273：352，1996。另一优选佐剂是皂苷，优选QS21(AquilaBiopharmaceuticals Inc.，Framingham，MA)，其可以单独或联合其它佐剂使用。例如，增强系统包括单磷酰脂A和皂苷衍生物的联合，例如QS21和3D-MPL的联合(WO 94/00153)，或其中用胆固醇淬灭QS21的较小反应原性组合物(见WO 96/33739)。其它优选制剂包含水包油型乳剂和生育酚。在水包油型乳剂中包含QS21、3D-MPL和生育酚的尤其有效的佐剂描述在WO 95/17210。

其它优选佐剂包括Montanide ISA 720(Seppic，法国)，SAF(Chiron，Calif.，美国)，ISCOMS(CSL)，MF-59(Chiron)，SBAS系列佐剂(例如，SBAS-2或SBAS-4，可从SmithKline Beecham，Rixensart，比利时获得)，Detox(Corixa公司；Seattle，Wash.)，RC-529(Corixa公司；Seattle，Wash.)和其它氨基葡糖苷4-磷酸氨基烷基酯(AGP)，如描述在待决美国专利申请系列08/853,826和09/074,720(其公开完整地并入本文作为参考)。

本文提供的所有疫苗均可以使用可导致抗原、免疫刺激剂和适宜载体或赋形剂相组合的熟知方法制备。本文描述的组合物可以作为缓释制剂(即，诸如胶囊、海绵或凝胶(例如，由多糖组成)等实现在给药后化合物的缓慢释放的制剂)的一部分给药。该制剂一般可以使用熟知技术(见例如，Coombes等，Vaccine 14：1429-1438，1996)制备，并可以通过例如口服、直肠或皮下埋植、或通过埋植在期望的靶位置处来给药。缓释制剂可以含有分散在载体基质中和/或包含在被控速膜包围的贮库中的多肽、多核苷酸或抗体。

在这些制剂中使用的载体具有生物相容性，还可以是生物可降解的；优选该制剂提供相对恒定水平的活性成分释放。此类载体包括乳酸-羟基乙酸共聚物的微粒，以及聚丙烯酸酯、胶乳、淀粉、纤维素和葡聚糖。其它缓释载体包括超分子生物载体，其包含非液体亲水核心(例如交联多糖或寡糖)和任选的含有两亲性化合物如磷脂的外层(见例如，U.S.专利5,151,254和PCT申请WO 94/20078，WO/94/23701和WO 96/06638)。活性化合物在缓释制剂中的含量取决于埋植位置、释放的速率和预期的持续时间和待治疗或预防的疾病的性质。

多种递送运输载体(vehicle)均可以用于药物组合物和疫苗中以利于靶向衣原体感染细胞的抗原特异性免疫应答的产生。递送运输载体包括抗原呈递细胞(APC)，如树突细胞、巨噬细胞、B细胞、单核细胞和可以通过改造成为有效的APC的其它细胞。这些细胞可以，但不必须，进行遗传修饰以增加呈递抗原的能力、提高对T细胞应答的激活和/或维持、本身具有抗衣原体作用和/或与受体具有免疫相容性(即，匹配的HLA单倍型)。一般APC可以从多种生物学液体和器官之任一种中分离得到，并可以是自体、同种异体、同基因或异基因细胞。

本发明的某些优选实施方案使用树突细胞或其祖先细胞作为抗原呈递细胞。树突细胞是高度有效的APC(Banchereau和Steinman，Nature 392：245-251，1998)，已被证实可以作为生理佐剂有效地引起预防性或治疗性免疫(见Timmerman和Levy，Ann.Rev.Med.50：507-529，1999)。一般，树突细胞可以根据其典型形状(原位时呈星形，体外具有可见的明显细胞质突起(树突))、高效摄取、加工和呈递抗原的能力以及活化幼稚T细胞应答的能力来鉴定。当然，可以对树突细胞进行改造使其表达正常情况下体内或离体均不存在于树突细胞上的特异细胞表面受体或配体，这些的修饰树突细胞是本发明所考虑的。作为树突细胞的替代方案，可以在疫苗中使用加载了抗原的树突细胞的分泌小泡(secreted vesicles antigen-loaded dendriticcells)(称作外吐小泡(exosome))(见Zitvogel等，Nature Med.4：594-600，1998)。

可以从外周血、骨髓、淋巴结、脾脏、皮肤、脐带血或任何其它适宜的组织或体液获得树突细胞和祖先细胞。例如，可以通过向收获自外周血的单核细胞的培养物中添加细胞因子组合如GM-CSF、IL-4、IL-13和/或TNFα，离体分化树突细胞。或者，可以通过向培养基中添加GM-CSF、IL-3、TNFα、CD40配体、LPS、flt3配体和/或其它能诱导树突细胞分化、成熟和增殖的化合物的组合，使收获自外周血、脐带血或骨髓的CD34阳性细胞分化成树突细胞。

树突细胞可方便地划分为“未成熟”和“成熟”细胞，这使得可以以一种简单的方式区分两个特征明显的表型。然而，这种命名法不应被理解为是对所有可能的中间分化阶段的排除。未成熟树突细胞可以表征为这样的APC，其具有与Fcγ受体和甘露糖受体高表达相关的高抗原摄取和加工能力。成熟表型典型的特征在于这些标记较低表达，但负责T细胞活化的细胞表面分子如I类和II类MHC、粘着分子(例如CD54和CD11)及共刺激分子(例如CD40，CD80，CD86和4-1BB)出现高表达。

APC一般可以用编码衣原体蛋白(或其部分或其它变体)的多核苷酸转染，以便该衣原体多肽或其免疫原性部分可以表达在细胞表面上。该转染可以离体进行，然后可以将包含该转染细胞的组合物或疫苗用于治疗目的，如本文所述。或者，可以给患者施用靶向树突细胞或其它抗原呈递细胞的基因递送运输载体，从而导致转染体内发生。例如，可以使用本领域熟知的任何方法体内和离体转染树突细胞，例如WO97/24447中所述的方法、或Mahvi等，Immunology and cell Biology75：456-460，1997中描述的基因枪方法。可以通过用衣原体多肽、DNA(裸露的或在质粒载体中的)或RNA；或用表达抗原的重组细菌或病毒(例如痘苗病毒、禽痘病毒、腺病毒或慢病毒载体)孵育树突细胞或祖先细胞，使树突细胞负载抗原。在负载之前，可以使多肽共价缀合可以提供T细胞帮助的免疫学伙伴(例如载体分子)。或者，可以用非缀合的免疫学伙伴单独地或在多肽存在时脉冲树突细胞。

药物组合物和疫苗的给药途径和频率，以及剂量随个体不同而不同。一般，药物组合物和疫苗可以通过注射(如皮内、肌内、静脉内或皮下)、鼻内(例如通过吸入)或口服给药。可以在1-36周的时间内1-3次给药。优选地，进行3次给药，以3-4个月为间隔，之后可以周期性给予加强接种。不同给药方案可能适于不同患者。适宜的给药量是这样的多肽或DNA量，当按上述给药时，该量能够在接受免疫的患者体内引起足以保护该患者在至少1-2年内免受衣原体感染的免疫应答。一般地，剂量中存在的多肽量(或由剂量中DNA原位产生的多肽量)为约1pg至约100mg/kg宿主，典型地约10pg至约1mg，优选约100pg至约1μg。适宜的给药量随患者的体积大小而变化，但典型地在约0.1mL至约5mL的范围内。

尽管可以在本发明药物组合物中使用本领域普通技术人员已知的任何适宜载体，但载体的类型取决于给药方式。对于肠胃外给药，如皮下注射，载体优选包含水、盐水、醇、脂肪、蜡或缓冲液。对于口服给药，可以使用以上任何一种载体或固体载体，如甘露醇、乳糖、硬脂酸镁、糖精钠、滑石、纤维素、葡萄糖、蔗糖和碳酸镁。还可以使用生物可降解微球(例如乳酸-羟基乙酸共聚物)作为本发明药物组合物的载体。使用的生物可降解微球公开在例如美国专利4,897,268和5,075,109中。

一般地，适当的剂量和治疗方案将提供足以造成治疗和/或预防益处的活性化合物量。该反应可以通过确定治疗患者与未治疗患者相比表现出的改善临床结果来监测。针对衣原体蛋白质的预先存在的免疫应答的增加一般与改善的临床结果相关。通常，可以使用标准增殖、细胞毒性或细胞因子试验评价这些免疫应答，所述试验可以使用治疗前后获自患者的样品来进行。

另一方面，本发明提供使用上述多肽诊断衣原体感染的方法。在此方面，本发明提供使用一种或多种上述多肽(单独地或相联合地)在生物学样品中检测衣原体感染的方法。为了清楚起见，在描述本发明诊断方法的具体实施方案时，使用术语“多肽”。然而，本领域技术人员明了，本发明的融合蛋白也可以用于这些方法中。

本文中“生物学样品”是指从患者获得的含有抗体的样品。优选地，该样品是全血、痰、血清、血浆、唾液、脑脊液或尿。更优选地，样品是获自患者的血液、血清或血浆样品。按下述，在试验中使用多肽，通过比较预先确定的截断值确定样品中是否存在针对该多肽的抗体。该抗体的存在表明早先被衣原体抗原致敏，而这可能指示衣原体感染。

在使用一种以上多肽的实施方案中，所用多肽优选具有互补性(即，一个多肽成分倾向于检测样品中的感染，而该感染却不能被另一多肽成分检测到)。一般可以通过单独地使用每一种多肽评价从一系列已知感染了衣原体的患者获得的血清样品，以鉴定出互补性多肽。确定出使用每一种多肽可以检测出哪些样品为阳性的(见下述)之后，可以配制将能够在大多数或全部测试样品中检测出感染的两种或多种多肽的组合。

对于使用一种或多种多肽检测样品中的抗体，本领域普通技术人员已知有多种形式的试验。见例如，Harlow和Lane，Antibodies：ALaboratory Manual，Cold Spring Harbor Laboratory，1988(并入本文作为参考)。在一个优选实施方案中，该试验涉及利用固定在固相支持物上的多肽结合并分离样品中的抗体。然后可以使用含有报道基团的检测试剂检测结合的抗体。适宜的检测试剂包括可与抗体/多肽复合物结合的抗体和用报道基团标记的游离多肽(例如在半竞争试验中)。或者，可以利用竞争试验，其中用报道基团标记可和多肽结合的抗体，并在使抗原和样品一起孵育之后允许该抗体与固定的抗原结合。样品中成分对标记的抗体和多肽结合的抑制程度指示样品与固定的多肽的反应性。

固相支持物可以是本领域普通技术人员已知的可以附着抗原的任何固体物质。例如，该固相支持物可以是微量滴定板中的测试孔，或硝酸纤维素或其它适宜的膜。或者，该支持物可以是小珠或盘，如玻璃、玻璃纤维、胶乳或塑料材料如聚苯乙烯或聚乙烯氯。支持物还可以是磁性颗粒或纤维光传感器，例如美国专利5,359,681中描述的那些。

可以使用本领域普通技术人员已知的多种技术使多肽与固相支持物结合。在本发明上下文中，术语“结合”是指非共价连接如吸附和共价附着(可以是抗原和支持物上的官能团之间的直接键合，或可以是通过交联剂的键合)。优选通过吸附与微量滴定板孔或膜结合。在这些情况下，吸附可以通过在适宜缓冲液中使多肽和固相支持物接触适当长的时间来实现。接触时间随温度改变，但典型地在约1小时至1天之间。一般地，用约10ng至约1mg，优选约100ng的多肽量接触塑料微量滴定板的一个孔就足以结合足够量的抗原。

多肽和固相支持物的共价附着一般可以通过首先使支持物和双功能试剂(即，可以和支持物和多肽上的官能团如羟基或氨基反应的试剂)反应来实现。例如，可以使用苯醌或通过支持物上的醛基基团和多肽上的胺和活性氢缩合，从而使多肽和具有适当聚合物包被的支持物结合(见例如Pierce Immunotechnology Catalog and Handbook，1991，A12-A13)。

在某些实施方案中，该试验是酶联免疫吸附测定(ELISA)。该试验可以通过首先使已固定在固相支持物(通常是微量滴定板)上的多肽抗原和样品接触，以便样品中的抗多肽的抗体可以和固定的多肽结合。然后从固定的多肽上除去未结合的样品，然后加入能够与固定的抗体-多肽复合物结合的检测试剂。之后使用适用于具体检测试剂的方法，测定保留与固相支持物结合的检测试剂的量。

更具体地，一旦如上述将多肽固定在支持物上之后，典型地封闭支持物上剩余的蛋白质结合位点。本领域普通技术人员已知的任何适宜的封闭剂，如牛血清白蛋白(BSA)或Tween 20^TM(Sigma Chemical Co.，St.Louis，MO)均可以采用。然后将固定的多肽和样品一起孵育，并允许抗体和抗原结合。可以在孵育之前用适宜的稀释剂如磷酸缓冲液溶液(PBS)稀释样品。一般地，适当的接触时间(即，孵育时间)是指足以检测到HGE感染样品中抗体的存在的时间段。优选地，接触时间足够长以能实现结合抗体和未结合抗体达平衡时达到的结合水平的至少95％的结合水平。本领域普通技术人员明了，达平衡所必需的时间可以容易地通过测试一段时间内的结合水平予以确定。室温下，一般大约30分钟的孵育时间是足够的。

然后可以通过用适当缓冲液，如含有0.1％Tween 20^TM的PBS洗涤固相支持物，除去未结合的样品。然后可以向固相支持物加上检测试剂。适当的检测试剂是可结合固定的抗体-多肽复合物并能被本领域已知的任何各种方法检测的任何化合物。优选地，检测试剂含有与报道基团缀合(conjugated)的结合试剂(如，A蛋白、G蛋白、免疫球蛋白、凝集素或游离抗原)。优选的报道基团包括酶(例如辣根过氧化物酶)、底物、辅因子、抑制剂、染料、放射性核素、化学发光基团、荧光基团和生物素。结合剂和报道基团的缀合可以使用本领域普通技术人员已知的标准方法实现。与多种报道基团缀合的通常结合剂还可以从许多商业来源(例如Zymed Laboratories，San Francisco，Calif.，和Pierce，Rockford，IL)购买。

然后，将检测试剂和固定的抗体-多肽复合物一起孵育足够长以检测结合的抗体的时间量。适当的时间长度一般可以从厂商说明书，或通过测试一段时间内的结合水平来确定。然后除去未结合的检测试剂并使用报道基团检测结合的检测试剂。用于检测报道基团的方法取决于报道基团的性质。对于放射性基团，一般闪烁计数或放射自显影是适当的。光谱法可以用于检测染料、化学发光基团和荧光基团。生物素可以使用偶联有不同的报道基团(通常是放射性或荧光基团或酶)的亲和素进行检测。酶报道基团一般可以通过加入底物(一般经过特定的时间段)，之后通过光谱法或其它方法分析反应产物进行检测。

为了确定样品中是否存在抗衣原体抗体，一般将从保持与固相支持物结合的报道基团检测到的信号和相应于预先确定的截断值的信号进行比较。在一个优选实施方案中，该截断值是固定的抗体和来自未感染患者的样品一起孵育时获得的平均信号。一般地，产生高于预先确定的截断值3个标准差的信号的样品被认为是衣原体感染阳性的。在另一优选实施方案中，截断值通过使用Receiver Operator曲线根据Sackett等的方法(临床流行病学：临床医学的基础科学(ClinicalEpidemiology：A Basic Science for Clinical Medicine)，LittleBrown and Co.，1985，pp.106-107)确定。简而言之，在该实施方案中，将该诊断测试结果的每一个可能截断值所对应的成对真阳性率(即灵敏度)和假阳性率(100％特异性)作图，然后可以从该图确定该截断值。图上最接近左上角的截断值(即包括了最大面积的值)是最准确的截断值，而产生的信号高于该方法所确定的截断值的样品可以被认为是阳性的。或者，可以沿着该图向左移动该截断值，以最小化假阳性率，或向右移动以最小化假阴性率。一般地，产生的信号高于该方法所确定的截断值的样品被认为是衣原体感染阳性。

在一个相关的实施方案中，该测定在快速流过或长条测试形式上进行，其中抗原被固定在硝酸纤维素等膜上。在该流过测试中，当样品经过该膜时，样品中的抗体与固定的多肽结合。然后当含有检测试剂的溶液流经该膜时，该检测试剂(例如，A蛋白-胶体金)将与该抗体-多肽复合物结合。接着可以按以上所述方法检测结合的检测试剂。在长条测试形式中，将结合了多肽的膜的一端浸入含有样品的溶液中。该样品沿该膜迁移通过含有检测试剂的区域并到达含有固定的多肽的区域。在多肽位置处检测试剂的浓缩指示了样品中存在抗衣原体抗体。典型地，检测试剂在该位置的浓缩产生能够通过肉眼观察的图形，例如线。无该图形，则指示阴性结果。一般地，对固定在该膜上的多肽的量进行选择，以便当生物样品含有的多肽水平足以在以上讨论的ELISA中产生阳性信号时，多肽位置处可以产生肉眼可识别的图形。优选地，固定在该膜上的多肽量在约25ng-约1μg之间，更优选在约50ng-约500ng之间。典型地用极少量(例如，一滴)的患者血清或血液就能够进行这些测试。

当然，有许多其它测试方法都适于和本发明多肽一起使用。以上的描述仅旨在作为范例。在这些方法中可以使用的可选择试验方案的一个例子是Western印迹，其中在凝胶上分离生物学样品中存在的蛋白质，然后使其暴露于结合剂。这些技术是本领域技术人员熟知的。

本发明还提供特异地与衣原体蛋白质结合的药剂，例如抗体和其抗原结合片段。在本文中，如果抗体或其抗原结合片段以可检测到的水平与衣原体蛋白质反应(在例如ELISA中)，而在相似条件下与无关蛋白质的反应不能被检测到时，则被认为其与衣原体蛋白质“特异结合”。这里所用“结合”是指两个独立分子之间的非共价连接，以致形成复合物。结合能力可以通过例如测定形成该复合物的结合常数来评价。结合常数是当用各成分的浓度乘积除该复合物的浓度时获得的值。一般地，在本发明的上下文中，当复合物形成的结合常数大于约10³L/mol时，两个化合物被认为是“相结合的”。该结合常数可以采用本领域熟知的方法测定。

采用本文提供的代表性试验，结合剂还能够区分患者是否存在衣原体感染。换言之，与衣原体蛋白质结合的抗体或其它结合剂将在至少约20％患有该病的患者中产生指示存在衣原体感染的信号，而将在至少约90％未发生感染的个体中产生指示该疾病不存在的信号。为了确定结合剂是否满足此要求，可以按本文所述方法测定在来自(用标准临床检验确定的)衣原体感染或未感染患者的生物学样品(例如血液、血清、痰、尿和/或活检组织)中是否存在与该结合剂结合的多肽。很明显，进行分析的患病和未患病样品的数量应当具有统计学意义。每个结合剂都应满足以上标准；然而，本领域普通技术人员将知道，可以联合使用多个结合剂以提高灵敏度。

满足以上要求的任何药剂都可以是结合剂。例如，结合剂可以是含有或不含有肽成分的核糖体、RNA分子或多肽。在一个优选实施方案中，结合剂是抗体或其抗原结合片段。抗体的制备可以采用本领域普通技术人员已知的多种技术中的任意一种。见例如Harlow和Lane，抗体：实验室手册，Cold Spring Harbor Laboratory，1988。一般地，可以通过细胞培养技术制备抗体，这些技术包括按本文所述制备单克隆抗体，或通过用抗体基因转染适宜的细菌或哺乳动物细胞宿主，以便使得可以产生重组抗体。在一项技术中，首先给多种哺乳动物(例如小鼠、大鼠、家兔、绵羊或山羊)中的任一种注射含有本发明多肽的免疫原。在该步骤中，可以将本发明的多肽不经修饰用作免疫原。或者，尤其是对于相对短的多肽，如果将该多肽与载体蛋白质，例如牛血清白蛋白或匙孔血蓝蛋白连接在一起，则可以引起极佳的免疫应答。给动物宿主注射免疫原，并优选地根据预先确定的时间表加入一次或多次加强免疫，然后定期采取该动物的血液。然后可以从抗血清中，通过例如采用与适宜固相支持物偶联的多肽进行亲和层析，纯化对该多肽具有特异性的多克隆抗体。

对目的抗原多肽具有特异性的单克隆抗体可以采用例如Kohler和Milstein的技术(Eur.J.Immunol-6：511-519，1976)，及其改良方法来制备。简而言之，这些方法涉及制备能够产生具有期望特异性(即与目的多肽的反应性)的抗体的永生化细胞系。这些细胞系可以从例如获自按上述方法免疫的动物的脾细胞制备。然后通过例如和骨髓瘤细胞融合伙伴，优选与该免疫动物同基因的骨髓瘤细胞融合，使该脾细胞永生化。多种融合技术均可以采用。例如，可以将脾细胞和骨髓瘤细胞与非离子去污剂混合几分钟，然后以低密度铺在支持杂种细胞而不支持骨髓瘤细胞生长的选择培养基上。优选的筛选技术采用了HAT(次黄嘌呤、氨基喋呤、胸苷)筛选。在足够长的时间之后，通常为约1-2周，可观察到杂种集落。选择单集落，并测试其培养物上清液与本发明多肽的结合活性。优选具有高反应性和特异性的杂交瘤。

可以从培养的杂交瘤集落的上清液中分离单克隆抗体。此外，还可以采用各种技术增加产量，例如将该杂交瘤细胞系注射入适宜的脊椎动物宿主例如小鼠的腹腔内。然后可以从腹水或血液中收获单克隆抗体。可以通过常规技术例如层析、凝胶过滤、沉淀和抽提从这些抗体中除去杂质。本发明多肽可以用于纯化方法例如亲和层析步骤中。

在某些实施方案中，可能优选采用抗体的抗原结合片段。这些片段包括Fab片段，它们可以采用标准技术制备。简而言之，可以通过在A蛋白珠柱上通过亲和层析从兔血清中纯化免疫球蛋白(Harlow和Lane，抗体：实验室手册，Cold Spring Harbor Laboratory，1988)，然后通过木瓜蛋白酶消化产生Fab和Fc片段。该Fab和Fc片段可以在A蛋白珠柱上通过亲和层析分离。

可以将本发明的单克隆抗体与一或多种治疗剂偶联在一起。在此方面适宜的治疗剂包括放射性核素、分化诱导剂、药物、毒素和它们的衍生物。优选的放射性核素包括⁹⁰Y、¹²³I、¹²⁵I、¹³¹I、¹⁸⁶Re、¹⁸⁸Re、²¹¹At和²¹²Bi。优选的药物包括氨甲蝶呤、及嘧啶和嘌呤的类似物。优选的分化诱导剂包括佛波酯和丁酸。优选的毒素包括篦麻毒素、相思豆毒素、白喉毒素、霍乱毒素、gelonin、假单孢菌外毒素、志贺氏菌毒素和美洲商陆抗病毒蛋白。

治疗剂可以与适宜的单克隆抗体直接或间接地(即通过接头基团)偶联(例如共价键合)。当药剂和抗体各具有能够和对方反应的取代基时，它们之间的直接反应是可能的。例如，其中一个上的亲核基团，例如氨基或巯基，可以和另一个上的含有羰基的基团例如酐或酰卤，或含有良好的离去基团(例如卤素)的烷基基团反应。

或者，可能期望将治疗剂和抗体通过接头基团偶联。接头基团能够作为间隔物起作用，使抗体和药剂分开以避免对结合性能的干扰。接头基团还可以用于增强药剂或抗体上取代基的化学反应性，由此增加偶联效率。化学反应性的增强还可以促进药剂、或药剂上官能团的原本是不可能实现的应用。

本领域技术人员将明了，有多种同功能和异功能性双功能或多功能试剂(例如描述于Pierce化学制品公司(Rockford，IL)产品目录中的那些)可以用作接头基团。偶联可以通过例如氨基、羧基、巯基或氧化的糖残基实现。有许多文献描述过该方法学，例如Rodwell等的美国专利4,671,958。

当治疗剂与本发明免疫缀合物的抗体部分分离而更为有效时，可能期望采用在内化进入细胞过程中或之后可断裂的接头基团。已有许多不同的可断裂接头基团的描述。在细胞内从这些接头基团处释放治疗剂的机制包括由二硫键的还原(例如Spitler的美国专利4,489,710)、光不稳定键的辐射(例如Senter等的美国专利4,625,014)、衍生的氨基酸侧链的水解(例如Kohn等的美国专利4,638,045)、血清补体介导的水解(例如Rodwell等的美国专利4,671,958)、和酸催化的水解(例如Blattler等的美国专利4,569,789)造成的断裂。

可能期望将一个以上的药剂与抗体偶联。在一个实施方案中，一个药剂的多个分子与一个抗体分子偶联。在另一个实施方案中，一种以上类型的药剂可以和一个抗体偶联。无论具体的实施方案如何，可以有多种方法制备带有一个以上药剂的免疫缀合物。例如，可以将一个以上的药剂直接与一个抗体分子偶联，或可以采用提供多个连接位点的接头。或者，可以采用载体。

载体可以以多种方式携带药剂，包括直接或通过接头基团的共价键合。适宜的载体包括蛋白质例如白蛋白(例如Kato等的美国专利4,507,234)、肽和多糖例如氨基葡聚糖(例如Shih等的美国专利4,699,784)。载体还可以通过非共价结合或通过包入例如脂质体小泡中(例如美国专利4,429,008和4,873,088)携带药剂。特异用于放射性核素药剂的载体包括放射性卤化小分子和螯合化合物。例如美国专利4,735,792公开了代表性的放射性卤化小分子和它们的合成。可以从螯合化合物形成放射性核素螯合物，这些螯合化合物包括含有氮和硫原子作为结合金属或金属氧化物放射性核素的供体原子的那些螯合化合物。例如，Davison等的美国专利4,673,562公开了代表性的螯合化合物和它们的合成。

对于这些抗体和免疫缀合物，可以采用多种给药途径。典型地，可以静脉内、肌内、皮下或在位点特异的区域中通过适当方法给药。很明显，抗体/免疫缀合物的精确剂量将随所用抗体、抗原密度、和抗体的清除速率而改变。

使用与上述测试方法相类似的测试方法和本领域技术人员熟知的其它技术，可以在诊断试验中使用抗体检测衣原体抗原的存在，由此提供在患者中检测衣原体感染的方法。

本发明诊断试剂还包含编码一个或多个上述多肽、或其一个或多个部分的DNA序列。例如，可以在基于聚合酶链式反应(PCR)的试验中使用至少两个寡核苷酸引物，以扩增来源于生物学样品的衣原体特异性cDNA，其中所述寡核苷酸引物中的至少一个对编码本发明多肽的DNA分子具有特异性。然后可以使用本领域熟知技术，例如凝胶电泳检测扩增的cDNA的存在。类似地，对编码本发明多肽的DNA具有特异性的寡核苷酸探针可以用于杂交试验中以检测生物学样品中本发明多肽的存在。

本文中，术语对DNA分子具有特异性的寡核苷酸引物/探针”是指与所讨论的DNA分子具有至少约80％、优选至少约90％、更优选至少约95％一致性的寡核苷酸序列。可以用于本发明诊断方法中的寡核苷酸引物和/或探针优选具有至少约10-40个核苷酸。在一个优选实施方案中，寡核苷酸引物含有编码本文公开的多肽之一的DNA分子的至少约10个连续核苷酸。优选地，用于本发明诊断方法中的寡核苷酸探针包含编码本文公开的多肽之一的DNA分子的至少约15个连续核苷酸。用于基于PCR的试验和杂交试验的技术是本领域熟知的(见例如，Mullis等同上；Ehrlich，同上)。由此，可以利用引物或探针检测生物学样品中的衣原体特异性序列。包含上述寡核苷酸序列的DNA探针或引物可以单独地或相互联合使用。

提供以下实施例作为举例说明，而非进行限制。

实施例1

分离编码衣原体抗原的DNA序列

基本上按Sanderson等(J.Exp.Med.1995，182：1751-1757)描述的方法通过沙眼衣原体LGVII的基因组DNA文库的表达克隆分离本发明衣原体抗原，该抗原表现出可以诱导PBMC增殖和免疫反应性T细胞系中的IFN-γ。

通过用沙眼衣原体LGV II的原生小体(elementary bodies)刺激来自无衣原体生殖道感染史的正常供体的PBMC，制备衣原体特异性T细胞系。此T细胞系称作TGL-8，被发现可以识别沙眼衣原体和肺炎衣原体感染的单核细胞来源的树突细胞。

在λZAP(Stratagene，La Jolla，CA)中构建经随机剪切的沙眼衣原体LGV II的基因组文库，并以30个克隆/孔的密度将扩增的文库铺在96孔微量滴度板中。在2mM IPTG存在下诱导细菌表达重组蛋白质3小时，然后将其沉淀并重悬在200μl RPMI 10％FBS中。将10μl诱导的细菌悬浮液转移至含有自体单核细胞来源的树突细胞的96孔板中。2小时诱导后，洗涤树突细胞以除去游离的大肠杆菌，然后加入衣原体特异性T细胞。通过测定响应大肠杆菌库出现的IFN-γ产生和T细胞增殖，鉴定阳性大肠杆菌库(pools)。

鉴定到4个阳性库，将其分解产生插入片断大小分别为481bp，183bp，110bp和1400bp的4个纯克隆(称作1-B1-66，4-D7-28，3-G3-10和10-C10-31)。1-B1-66，4-D7-28，3-G3-10和10-C10-31的测定的DNA序列分别提供在SEQ ID NO：1-4。克隆1-B1-66大约位于沙眼衣原体基因组(NCBI沙眼衣原体数据库)的536690区域中。在克隆1-B1-66中，鉴定到一个编码早先鉴定的9kDa蛋白质(Stephens等，Genbank登录号AE001320)的开放阅读框(ORF)(核苷酸第115-375位)，该蛋白的序列提供在SEQ ID NO：5中。克隆4-D7-28是相同ORF中的较小区域(1-B1-66的第22至82位氨基酸)。克隆3-G3-10大约位于沙眼衣原体基因组的74559区域中。该插入片断相对于其在基因组中的取向是以反义方向克隆的。克隆10-C10-31含有相应于早先公开的沙眼衣原体S13核糖体蛋白质的序列(Gu，L.等，J.Bacteriology，177：2594-2601，1995)的开放阅读框。4-D7-28和10-C10-31的预测蛋白质序列分别提供在SEQ ID NO：6和12中。3-G3-10的预测蛋白质序列提供在SEQ ID NO：7-11中。

在相关一系列筛选研究中，使用另一种T细胞系筛选上述沙眼衣原体LGV II的基因组DNA文库。通过用经沙眼衣原体LGV II原生小体感染的自体单核细胞来源的树突细胞刺激患者的PBMC，从衣原体生殖道感染患者获得衣原体特异性T细胞系(TCT-1)。一个克隆4C9-18(SEQ ID NO：21)含有1256bp插入片断，在标准增殖试验中测量时，其从衣原体特异性T细胞系TCT-1引起特异性免疫应答。随后的分析显示该克隆含有3个已知序列：硫辛酰胺脱氢酶(Genbank登录号AE001326)，公开在SEQ ID NO：22中；假定的蛋白质CT429(Genbank登录号AE001316)，公开在SEQ ID NO：23中；泛醌甲基转移酶CT428(Genbank登录号AE001316)开放阅读框的一部分，公开在SEQ ID NO：24中。

在涉及克隆4C9-18(SEQ ID NO：21)的进一步研究中，在克隆CtL2-LPDA-FL中表达沙眼衣原体(LGV II)的硫辛酰胺脱氢酶(SEQ IDND：22)的全长氨基酸序列，所述克隆公开在SEQ ID NO：90中。

为了进一步表征含有T细胞刺激表位的此开放阅读框，将氨基端带有一段编码6×组氨酸标签的cDNA序列并含有克隆4C9-18第1-695位核苷酸的cDNA片断亚克隆在pET17b载体(Novagen，Madison，WI)的NdeI/EcoRI位点中，称作克隆4C9-18#2 BL21 pLys S(SEQ ID NO：25，相应的氨基酸序列提供在SEQ ID NO：26)，并将其转化至大肠杆菌中。用2mM IPTG选择性诱导转化的大肠杆菌3小时，导致从克隆4C9-18#2 BL21 pLysS表达产生一个26kDa蛋白质，这得到标准考马斯亮兰染色的SDS-PAGE的证实。为了确定克隆4C9-18#2 BL21pLysS编码的蛋白质的免疫原性，将表达该26kDa蛋白质的大肠杆菌在1×10⁴单核细胞来源的树突细胞上滴定，并孵育2小时。洗涤树突细胞培养物，加入2.5×10⁴T细胞(TCT-1)并允许再孵育72个小时，此时通过ELISA测定培养物上清液中IFN-γ的水平。如图1所示，发现T细胞系TCT-1可响应诱导的培养物(如IFN-g测量的)，从而指示了抗硫辛酰胺脱氢酶序列的衣原体特异性T细胞应答。类似地，通过标准增殖试验，证实克隆4C9-18#2 BL21 pLysS编码的蛋白质可以刺激TCT-1T细胞系。

使用上述CD4+T细胞表达克隆技术鉴定其它沙眼衣原体抗原的随后研究产生了其它克隆。利用TCT-1和TCL-8衣原体特异性T细胞系以及TCP-21T细胞系筛选沙眼衣原体LGVII基因组文库。TCP-21T细胞系来源于对肺炎衣原体具有体液免疫应答的患者。TCT-1细胞系鉴定到37个阳性库(pools)，TCT-3细胞系鉴定到41个阳性库，而TCP-21细胞系鉴定到2个阳性库。下列克隆来源于其中的10个阳性库。通过TCP-21细胞系鉴定到的克隆11-A3-93(SEQ ID NO：64)，是与HAD超家族(CT103)具有同源性的1339bp基因组片断。相同克隆中的第二个插入片断与互补链上存在的fab I基因(CT104)具有同源性。使用TCP-21细胞系鉴定到的克隆11-C12-91(SEQ ID NO：63)，具有一个269bp插入片断，该片断是OMP2基因(CT443)的一部分并与肺炎衣原体60kDa富含半胱氨酸的外膜蛋白质具有同源性。

使用TCT-3细胞系鉴定到的克隆11-G10-46(SEQ ID NO：62)含有一个与假拟蛋白CT610具有同源性的688bp插入片断。使用TCT-3细胞系鉴定到的克隆11-G1-34(SEQ ID NO：61)具有两个部分开放阅读框(ORF)，插入片断的大小为1215bp.一个ORF与苹果酸脱氢酶基因(CT376)具有同源性，而另一个ORF与糖元水解酶基因(CT042)具有同源性。使用TCT-3细胞系鉴定到的克隆11-H3-68(SEQ ID NO：60)具有两个ORF，总插入片断大小为1180bp。一个部分ORF编码质粒编码的PGP6-D毒力蛋白质，而另一ORF是L1核糖体基因(CT318)的完整ORF。使用TCT-3鉴定到的克隆11-H4-28(SEQ ID NO：59)具有552bp的插入片断大小，是dnaK基因(CT396)ORF的一部分。使用TCT-1鉴定到的克隆12-B3-95(SEQ ID NO：58)具有463bp插入片断，是硫辛酰胺脱氢酶基因(CT557)ORF的一部分。克隆15-G1-89和12-B3-95相同(分别是SEQ ID NO：55和58)，它们是使用TCT-1细胞系鉴定到的，具有463bp的插入片断大小，是硫辛酰胺脱氢酶基因(CT557)ORF的一部分。使用TCT-1细胞系鉴定到的克隆12-G3-83(SEQ ID NO：57)具有1537bp插入片断，并具有假定蛋白质CT622的部分ORF。

使用TCT-3细胞系鉴定到的克隆23-G7-68(SEQ ID NO：79)含有950bp插入片断并含有L11核糖体ORF的一小部分、L1核糖体蛋白质的整个ORF和L10核糖体蛋白质的部分ORF。此外，该克隆还鉴定到患者细胞系CT4，CT5，CT11，CT12和CHH037。使用TCT-1细胞系鉴定到的克隆22-F8-91(SEQ ID NO：80)含有395bp插入片断，该片断在该克隆的互补链上含有部分pmpC ORF。使用TCT-3细胞系鉴定到的克隆21-E8-95(SEQ ID NO：81)含有2,085bp插入片断，其含有部分CT613 ORF、CT612的完整ORF、CT611的完整ORF和CT610的部分ORF。使用TCT-3细胞系鉴定到的克隆19-F12-57(SEQ ID NO：82)含有405bp插入片断，该片断含有部分CT858 ORF和小部分recAORF。使用TCT-3细胞系鉴定到的克隆19-F12-53(SEQ ID NO：83)含有379bp插入片断，该片断是编码谷氨酰tRNA合成酶的CT455的部分ORF。使用TCT-3细胞系鉴定到的克隆19-A5-54(SEQ ID NO：84)含有715bp插入片断，其是隐蔽性质粒的ORF3的部分(该克隆的互补链)。使用TCT-1细胞系鉴定到的克隆17-E1-72(SEQ ID NO：85)含有476bp插入片断，该片断是Opp_2和pmpD的ORF的一部分。该克隆的pmpD区域被克隆15-H2-76的pmpD区域涵盖。使用患者细胞系CT3，CT1，CT4，和CT12鉴定到的克隆17-C1-77(SEQ ID NO：86)含有1551bp插入片断，其是CT857 ORF的一部分和CT858 ORF的一部分。使用TCT-1细胞系鉴定到的克隆15-H2-76(SEQ ID NO：87)含有3,031bp插入片断，该片断中含有pmpD ORF的大部分、CT089 ORF的一部分以及SycE的ORF的一部分。克隆15-A3-26(SEQ ID NO：88)含有976bp插入片断，该片断中含有CT858的部分ORF。使用患者细胞系CL8，TCT-10，CT1，CT5，CT13和CHH037鉴定到的克隆17-G4-36，(SEQ ID NO：267)含有680bp插入片断，其与该质粒中的β-gal的阅读框相符，并与DNA指导的RNA聚合酶β亚基(SerD中的CT315)的部分ORF同源。

上述其中几个克隆与多种多态性膜蛋白质具有同源性。沙眼衣原体基因组序列含有9个多态性膜蛋白基因组成的家族(称作pmp)。这些基因称作pmpA、pmpB、pmpC、pmpD、pmpE、pmpF、pmpG、pmpH和pmpI。这些基因表达的蛋白质被认为在产生针对衣原体感染的保护性免疫应答方面具有生物学重要意义。尤其是，pmpC、pmpD、pmpE和pmpI含有可预测的信号肽，提示它们是外膜蛋白，因此是潜在的免疫靶标。

基于沙眼衣原体LGVII血清变型序列，设计了引物对以PCR扩增pmpC、pmpD、pmpE、pmpG、pmpH和pmpI的全长片断。将得到的片断亚克隆至DNA痘苗载体JA4304或JAL(其是具有修饰的接头的JA4304)(SmithKine Beecham，伦敦，英国)中。具体地，使用5’寡核苷酸GAT AGG CGC GCC GCA ATC ATG AAA TTT ATG TCA GCT ACT GCT G和3’寡核苷酸CAG AAC GCG TTT AGA ATG TCA TAC GAG CAC CGC A(分别提供在SEQ ID NO：197和198)，将pmpC亚克隆至JAL载体中。将短核苷酸序列GCAATC(SEQ ID NO：199)插在ATG上游以产生Kozak样序列后，在本领域熟知的条件下PCR扩增该基因，并将其连接至JAL载体的5’ASCI/3’MluI位点。所获表达载体含有包含5325个核苷酸具有推测的信号序列的全长pmpC基因(SEQ ID NO：173)，其编码187kD蛋白质(SEQ ID NO：179)。使用如下寡核苷酸PCR扩增pmpD基因：5’寡核苷酸TGC AAT CAT GAG TTC GCA GAA AGA TAT AAA AAG C(SEQ IDNO：200)和3’寡核苷酸CAG AGC TAG CTT AAA AGA TCA ATC GCA ATCCAG TAT TC(SEQ ID NO：201)，然后将该基因亚克隆至JA4303痘苗载体中。使用本领域熟知的标准技术将该基因连接至JA4304痘苗载体的5’平端HIII/3’MluI位点中。将CAATC(SEQ ID NO：202)插在ATG的上游以产生Kozak样序列。由于平端连接造成HindIII位点的最后一个苏氨酸和Kozak样序列的最后一个甘氨酸丢失，故该克隆是唯一的。该插入片断，4593bp核苷酸片断(SEQ ID NO：172)，是含有假定的信号序列的pmpD全长基因，编码161kD蛋白质(SEQ ID NO：178)。使用5’寡核苷酸TGC AAT CAT GAA AAA AGC GTT TTT CTT TTT C(SEQID NO：203)，和3’寡核苷酸CAG AAC GCG TCT AGA ATC GCA GAG CAATTT C(SEQ ID NO：204)将pmpE亚克隆至JA4304载体。PCR扩增后，将该基因连接至JA4303的5’平端HIII/3’MluI位点中。为了有利于此，将短核苷酸序列TGCAATC(SEQ ID NO：293)加在起始密码子的上游以构建Kozak样序列并重建HindIII位点。该插入片断是含有假定的信号序列的全长pmpE基因(SEQ ID NO：171)。pmpE基因编码105kD蛋白质(SEQ ID NO：177)。使用5’寡核苷酸GTG CAATCA TGA TTC CTCAAG GAA TTT ACG(SEQ ID NO：205)，和3’寡核苷酸CAG AAC GCG TTTAGA ACC GGA CTT TAC TTC C(SEQ ID NO：206)PCR扩增pmpG基因，并将其亚克隆至JA4303载体中。相似的克隆策略被用于pmpI和pmpK基因。此外，设计引物对以PCR扩增pmp基因的全长或重叠片断，然后为进行蛋白质表达将它们亚克隆在pET17b载体(Novagen，Madison，WI)中，然后将其转染至大肠杆菌BL21 pLysS中进行表达，并随后利用Novagen提供的组氨酸-镍亲和层析方法学纯化。为了促进蛋白质表达，编码重组蛋白质的如下所述几个基因缺少天然信号序列。pmpC的全长蛋白质表达是通过表达代表氨基和羧基端的两个重叠片断来实现的。缺少信号序列的pmpC氨基端部分(SEQ ID NO：187，相应的氨基酸序列提供在SEQ ID NO：195中)使用5’寡核苷酸CAG ACA TAT GCATCA CCA TCA CCA TCA CGA GGC GAG CTC GAT CCA AGA TC(SEQ ID NO：207)，和3’寡核苷酸CAG AGG TAC CTC AGA TAG CAC TCT CTC CTA TTAAAG TAG G (SEQ ID NO：208)亚克隆至载体的5’NdeI/3’KPN克隆位点中。使用如下引物：5’寡核苷酸CAG AGC TAG CAT GCA TCA CCA TCACCA TCA CGT TAA GAT TGA GAA CTT CTC TGG C (SEQ ID NO：209)，和3’寡核苷酸CAG AGG TAC CTT AGA ATG TCA TAC GAG CAC CGC AG(SEQ ID NO：210)，将pmpC的羧基端部分，即该基因的羧基端片断(SEQ ID NO：186，相应的氨基酸序列提供在SEQ ID NO：194中)亚克隆至该表达载体的5’NheI/3’KPN克隆位点。pmpD也以两个重叠蛋白质的形式表达。缺少信号序列的pmpD氨基端部分(SEQ ID NO：185，相应的氨基酸序列提供在SEQ ID NO：193中)含有pET17b的起始密码子并表达为80kD蛋白质。为了蛋白质表达和纯化目的，在起始密码子之后接6组氨酸标签，并将其融合在该基因的第28个氨基酸(第84个核苷酸)的位置处。使用如下引物，5’寡核苷酸CAG ACA TAT GCA TCACCA TCA CCA TCA CGG GTT AGC(SEQ ID NO：211)，和3’寡核苷酸CAG AGG TAC CTC AGC TCC TCC AGC ACA CTC TCT TC(SEQ ID NO：212)，以便拼接至载体的5’NdeI/3’KPN克隆位点中。pmpD-羧基端部分(SEQID NO：184)表达为92kD蛋白(SEQ ID NO：192)。为了表达和随后的纯化，包括额外的甲硫氨酸、丙氨酸和丝氨酸，这些氨基酸代表pET17b载体的起始密码子和头两个氨基酸。将甲硫氨酸、丙氨酸和丝氨酸下游的6组氨酸标签融合在该基因的第691个氨基酸(第2073个核苷酸)的位置。使用5’寡核苷酸CAG AGC TAG CCA TCA CCA TCA CCA TCA CGGTGC TAT TTC TTG CTT ACG TGG(SEQ ID NO：213)和3’寡核苷酸CAGAGG TAC TTn AAA AGA TCA ATC GCA ATC CAG TAT TCG(SEQ ID NO：214)将插入片断亚克隆至该表达载体的5’NheI/3’KPN克隆位点。pmpE表达为106kD蛋白质(SEQ ID NO：183，相应的氨基酸序列提供在SEQ ID NO：191中)。此pmpE插入片断也缺少天然信号序列。在本领域熟知的条件下，使用如下寡核苷酸引物PCR扩增该基因：5’寡核苷酸CAG AGGATC CAC ATC ACC ATC ACC ATC ACG GAC TAG CTA GAG AGG TTC(SEQID NO：215)，和3’寡核苷酸CAG AGA ATT CCT AGA ATC GCA GAG CAATTT C (SEQ ID NO：216)，并将扩增的插入片断连接至JA4303的5’BamHI/3’EcoRI位点。SEQ ID NO：217中提供的短核苷酸序列被插在起始密码子的上游，以构建Kozak样序列和重建HindIII位点。该表达蛋白含有来自pET17b表达载体的起始密码子和下游21个氨基酸，即MASMTGGQQMGRDSSLVPSSDP(SEQ ID NO：218)。此外，在上述序列的上游包括6组氨酸标签，该标签融合在基因的第28位氨基酸(第84位核苷酸)处，这就消除了假定的信号肽。SEQ ID NO：183提供的序列和SEQ ID NO：191提供的相应氨基酸序列都不包括这些额外序列。pmpG基因(SEQ ID NO：182，相应氨基酸序列提供在SEQ ID NO：190中)在本领域熟知的条件下使用如下寡核苷酸引物进行PCR扩增：5’寡核苷酸CAG AGG TAC CGC ATC ACC ATC ACC ATC ACA TGA TTC CTC AAGGAA TTT ACG(SEQ ID NO：219)，和3’寡核苷酸CAG AGC GGC CGC TTAGAA CCG GAC TTT ACT TCC(SEQ ID NO：220)，然后将其连接至表达载体的5’KPN/3’NotI克隆位点。表达的蛋白质在氨基端含有额外的氨基酸序列，即，MASMTGGQQNGRDSSLVPHHHHHH(SEQ ID NO：221)，其包含来自pET17b表达载体的起始密码子和其它序列。在本领域熟知的条件下使用如下寡核苷酸引物PCR扩增pmpI基因(SEQ ID NO：181，相应的氨基酸序列提供在SEQ ID NO：189中)：5’寡核苷酸CAG AGCTAG CCA TCA CCA TCA CCA TCA CCT CTT TGG CCA GGA TCC C(SEQ IDNO：222)，和3’寡核苷酸CAG AAC TAG TCT AGA ACC TGT AAG TGG TCC(SEQ ID NO：223)，将其连接至表达载体的5’NheI/3’SpeI克隆位点。该95kD表达蛋白在蛋白质的氨基末端含有来自pET17b载体的起始密码子和额外的丙氨酸和丝氨酸。此外，将6组氨酸标签融合在该基因的第21位氨基酸位置，这就消除了假定的信号肽。

使用TCT-3细胞系鉴定到的克隆14-H1-4(SEQ ID NO：56)含有TSA基因，巯基特异性抗氧化剂-CT603的完整ORF(CT603的ORF是肺炎衣原体的CPn0778的同系物)。扩增克隆14-H1-4中的TSA开放阅读框，以便该表达蛋白具有额外的甲硫氨酸和6×组氨酸标签(氨基末端)。将该扩增的插入片断亚克隆至pET17b载体的Nde/EcoRI位点中。用IPTG诱导该克隆后，通过Ni-NTA琼脂糖亲和层析纯化22.6kDa蛋白质。对于编码TSA基因的克隆14-H1-4的195个氨基酸ORF的测定氨基酸序列提供在SEQ ID NO：65中。进一步的分析得到TSA基因的全长克隆，称作CTL2-TSA-FL，该全长氨基酸序列提供在SEQ ID NO：92中。

在其它研究中，按上述通过TCT-1和TCT-3T细胞系鉴定到10个其它克隆。TCT-1细胞系鉴定到的克隆是：16-D4-22、17-C5-19、18-C5-2、20-G3-45和21-C7-66；TCT-3细胞系鉴定到的克隆是：17-C10-31、17-E2-9、22-A1-49和22-B3-53。克隆21-G12-60被TCT-1和TCT-3T细胞系识别。此外，克隆20-G3-45含有对pmpB具有特异性的序列，是针对患者系CT1和CT4鉴定到的。使用TCT-1细胞系鉴定到的克隆16-D4-22(SEQ ID NO：119)含有953bp插入片断，其含有两个基因，沙眼衣原体质粒开放阅读框3(ORF3)和ORF4的部分，用于哺乳动物细胞中生长。克隆17-C5-19(SEQ ID NO：118)含有951bp插入片断，其含有编码clpP_1蛋白酶的DT431的部分ORF和CT430(二氨基庚二酸差向异构酶)的部分ORF。使用TCT-1细胞系鉴定到的克隆18-C5-2(SEQ ID NO：117)具有446bp插入片断，其是S1核糖体蛋白的部分ORF。使用TCT-1细胞系鉴定到的克隆20-G3-45(SEQ ID NO：116)含有437bp插入片断，其是pmpB基因(CT413)的一部分。使用TCT-1细胞系鉴定到的克隆21-C7-8(SEQ IDNO：115)含有995bp插入片断，其编码dnaK样蛋白质的一部分。该克隆的插入片断与被证明是dnaK基因CT396的一部分的TCT-3克隆11-H4-28(SEQ ID NO：59)的插入片段并不重叠。使用TCT-3细胞系鉴定到的克隆17-C10-31 (SEQ ID NO：114)含有976bp插入片断。该克隆含有CT858(含有IRBP和DHR域的蛋白酶)的部分ORF。克隆17-E2-9(SEQ ID NO：113)两个基因CT611和CT610的部分ORF，其横跨1142bp的插入片断。使用TCT-3细胞系鉴定到的克隆22-A1-49(SEQ ID NO：112)在698bp插入片断中也含有两个基因。CT660(DNA旋转酶{gyrA_2})的部分ORF存在于上方链上，而假拟蛋白CT659的完整ORF存在于互补链上。使用TCT-1细胞系鉴定到的克隆22-B3-53(SEQ ID NO：111)具有267bp插入片断，其编码GroEL(CT110)的部分ORF。由TCT-1和TCT-3细胞系鉴定到的克隆21-G12-60(SEQ IDNO：110)含有1461bp插入片断，其含有假拟蛋白CT875、CT229和CT228的部分ORF。

通过用几个衣原体感染患者的汇合血清根据本领域熟知技术筛选λScreen-1载体(Novagen，Madison，WI)中的沙眼衣原体(LGV II血清变型)基因组表达文库，获得其它的衣原体抗原。鉴定到如下免疫反应性克隆，并对含有衣原体基因的插入片断测序：CTL2#1(SEQ ID NO：71)；CTL2#2(SEQ ID NO：70)；CTL2#3-5’(SEQ ID NO：72，代表5’末端的第一个测定的基因组序列)；CTL2#3-3’(SEQ ID NO：73，代表3’末端的第二个测定的基因组序列)；CTL2#4(SEQ ID NO：53)；CTL2#5(SEQ ID NO：69)；CTL2#6(SEQ ID NO：68)；CTL2#7(SEQ IDNO：67)；CTL2#8b(SEQ ID NO：54)；CTL2#9(SEQ ID NO：66)；CTL2#10-5’(SEQ ID NO：74，代表5’末端的第一个测定的基因组序列)；CTL2#10-3’(SEQ ID NO：75，代表3’末端的第二个测定的基因组序列)；CTL2#11-5’(SEQ ID NO：45，代表5’末端的第一个测定的基因组序列)；CTL2#11-3’(SEQ ID NO：44，代表3’末端的第二个测定的基因组序列)；CTL2#12(SEQ ID NO：46)；CTL2#16-5’(SEQ IDNO：47)；CTL2#18-5’(SEQ ID NO：49，代表5’末端的第一个测定的基因组序列)；CTL2#18-3’(SEQ ID NO：48，代表3’末端的第二个测定的基因组序列)；CTL2#19-5’(SEQ ID NO：76，代表5’末端的测定的基因组序列)；CTL2#21(SEQ ID NO：50)；CTL2#23(SEQ ID NO：51；和CTL2#24(SEQ ID NO：52)。

通过血清学表达克隆，鉴定到其它的沙眼衣原体抗原。这些研究使用几个衣原体感染个体的汇合血清，如上所述，但除了IgG外还使用IgA和IgM抗体作为二抗。通过此方法筛选到的克隆增加了对衣原体感染的早期免疫应答(即，粘膜体液免疫应答)所识别抗原的鉴定。我们对如下免疫反应性克隆进行了表征并对含有衣原体基因的插入片断进行了测序：CTL2gam-1(SEQ ID NO：290)，CTL2gam-2(SEQ ID NO：289)，CTL2gam-5(SEQ ID NO：288)，CTL2gam-6-3’(SEQ ID NO：287，代表3’末端的第二个测定的基因组序列)，CTL2gam-6-5’(SEQ ID NO：286，代表5’末端的第一个测定的基因组序列)，CTL2gam-8(SEQ IDNO：285)，CTL2gam-10(SEQ ID NO：284)，CTL2gam-13(SEQ ID NO：283)，CTL2gam-15-3’(SEQ ID NO：282，代表3’末端的第二个测定的基因组序列)，CTL2gam-15-5’(SEQ ID NO：281，代表5’末端的第一个测定的基因组序列)，CTL2gam-17(SEQ ID NO：280)，CTL2gam-18(SEQ ID NO：279)，CTL2gam-21(SEQ ID NO：278)，CTL2gam-23(SEQID NO：277)，CTL2gam-24(SEQ ID NO：276)，CTL2gam-26(SEQ IDNO：275)，CTL2gam-27(SEQ ID NO：274)，CTL2gam-28(SEQ ID NO：273)，CTL2gam-30-3’(SEQ ID NO：272，代表3’末端的第二个测定的基因组序列)和CTL2gam-30-5’(SEQ ID NO：271，代表5’末端的第一个测定的基因组序列)。

实施例2

沙眼衣原体抗原诱导T细胞增殖和干扰素-γ产生

按如下确定重组沙眼衣原体抗原诱导T细胞增殖和干扰素γ产生的能力。

通过IPTG诱导蛋白质，并利用Ni-NTA琼脂糖亲和层析纯化(Webb等，J.Immunology 157：5034-5041，1996)。然后根据诱导PBMC制品中T细胞增殖的能力，筛选纯化的多肽。将来自沙眼衣原体患者的PBMC以及来自其T细胞已知可以响应衣原体抗原而增殖的正常供体的PBMC培养在含有补加10％汇合的人血清和50μg/m1庆大霉素的RPMI1640的培养基中。一式两份地以O.5至10μg/ml的浓度加入纯化的多肽。在96孔圆底平板中以200μl体积培养6天后，从每个孔中取出50μl培养基用于确定IFN-γ的水平，如下述。然后用1μCi/孔氚化胸苷脉冲平板再18个小时，收获细胞然后使用气体(gas)闪烁计数器测定氚的摄取。在重复试验中导致细胞增殖比在单纯培养基培养的细胞中观察到的增殖大3倍的组分被认为是阳性的。

使用酶联免疫吸附测定方法(ELISA)测定IFN-γ。室温用抗人IFN-γ的小鼠单克隆抗体(PharMingen，San Diego，CA)在PBS中包被ELISA平板4小时。然后用含有5％(w/v)脱脂干奶粉的PBS室温封闭孔1小时。在PBS/0.2％Tween-20中洗涤平板6次，然后在ELISA平板中室温过夜孵育于培养基中1∶2稀释的样品。再次洗涤平板，并在每孔中加入PBS/10％正常山羊血清中1∶3000稀释的多克隆兔抗人IFN-γ血清。然后，室温孵育平板2小时，洗涤平板后加入PBS/5％脱脂干奶粉中1∶2000稀释的辣根过氧化物酶偶联的抗兔IgG(Sigma ChemicalSo.，St.Louis，MO)。室温再孵育两小时后，洗涤平板并加入TMB底物。20分钟后用1N硫酸终止反应。使用570nm作为参考波长在450nm测定光密度。在两次重复试验中均导致产生的OD比单纯培养基中培养的细胞的平均OD加3个标准差大两倍的组分被认为是阳性的。

使用上述方法学，发现重组1B1-66蛋白质(SEQ ID NO：5)以及分别相应于SEQ ID NO：5氨基酸残基第48-67位(SEQ ID NO：13；称作1-B1-66/48-67)和第58-77位(SEQ ID NO：14，称作1B1-66/58-77)的两个合成肽可以在用于筛选沙眼衣原体LGV II基因组文库的衣原体特异性T细胞系中诱导增殖反应和IFN-γ产生。

进一步的研究鉴定了核糖体S13蛋白质中沙眼衣原体特异性T细胞表位。使用本领域熟知的标准表位作图技术，用来自供体CL-8的衣原体特异性T细胞系(T细胞系TCL-8 EB/DC)在核糖体S13蛋白质(rS13)中鉴定到两个T细胞表位。图8显示，第一肽rS131-20(SEQID NO：106)与相应肺炎衣原体序列100％相同，解释了该T细胞系和重组沙眼衣原体和肺炎衣原体的rS13的交叉反应性。对第二肽rS1356-75(SEQ ID NO：108)的应答是沙眼衣原体特异的，说明在此健康无症状供体中的rS13应答是由暴露于沙眼衣原体而非肺炎衣原体或任何其它微生物感染引起的。

如实施例1所述，使用TCP-21细胞系鉴定的克隆11-C12-91(SEQID NO：63)具有269bp插入片断，其是OMP2基因(CT443)的一部分并与肺炎衣原体60kDa富含半胱氨酸的外膜蛋白(称作OMCB)具有同源性。为了进一步定义反应性表位，使用一系列重叠肽和先前描述的免疫测定方法进行表位作图。简而言之，在存在1×10⁴个单核细胞来源的树突细胞时用来源于沙眼衣原体和肺炎衣原体的非感染性原生小体或用来源于沙眼衣原体或肺炎衣原体OMCB蛋白质序列的肽(0.1μg/ml)刺激2.5×10⁴TCP-21 T细胞，以确定增殖应答。该TCP-21 T细胞应答表位CT-OMCB#167-186、CT-OMCB#171-190、CT-OMCB#171-186，并以较小程度应答CT-OMCB#175-186(分别是SEQ ID NO：249-252)。值得注意的是，该TCP-21 T细胞系还产生针对同源性肺炎衣原体肽CP-OMCB#171-186(SEQ ID NO：253)的增殖应答，该应答与对沙眼衣原体肽的应答相比是相同的或更高。在2位(即，Asp替代Glu)和4位(即，Cys替代Ser)上的氨基酸替代不改变T细胞的增殖应答，由此说明该表位是沙眼衣原体和肺炎衣原体间的交叉反应性表位。

为了进一步阐明上述表位，在表位作图实验中使用另一种T细胞系，TCT-3。除了仅测试来自沙眼衣原体的肽外，按上述进行免疫测定。该T细胞响应两种肽CT-OMCB#152-171和CT-OMCB#157-176(分别是SEQ ID NO：246和247)产生增殖应答，由此确定出沙眼衣原体此富含半胱氨酸外膜蛋白中的另一免疫原性表位。

克隆14H1-4(SEQ ID NO：56，相应全长氨基酸序列提供在SEQ IDNO：92中)是使用TCT-3细胞系在早先描述的CD4 T细胞表达克隆系统中鉴定到的，其被证明含有巯基特异性抗氧化剂基因(CT603)(称作TSA)的完整ORF。按上述进行表位作图免疫测定试验以进一步定义该表位。该TCT-3 T细胞对重叠肽CT-TSA#96-115，CT-TSA#101-120和CT-TSA#106-125(分别是SEQ ID NO：254-256)表现出强增殖应答，由此证明了沙眼衣原体血清变型LGV II的巯基特异性抗氧化剂基因中的免疫反应性表位。

实施例3

制备合成多肽

可以在Millipore 9050肽合成仪上使用FMOC化学和HPTU(O-苯并三唑-N，N，N’，N’-四甲基脲鎓六氟磷酸盐)活化，合成肽。可以使Gly-Cys-Gly序列与肽的氨基端连接以提供缀合(conjugating)或标记该肽的方法。从固相支持物上切下肽可以使用如下切割混合物进行：三氟乙酸∶乙二硫醇∶苯甲硫醚∶水∶酚(40∶1∶2∶2∶3)。切割2小时后，可以在冰甲基-叔丁基醚中沉淀肽。然后可以将肽沉淀溶解在含有0.1％三氟乙酸(TFA)的水中，然后将其冻干，再用C18反向HPLC纯化。可以使用水中的0-60％乙腈梯度(含有0.1％TFA)洗涤肽。将纯化的组分冻干后，可以使用电喷射质谱和氨基酸分析对肽进行表征。

实施例4

使用逆转录病毒表达载体系统及随后的免疫学分析

分离和表征编码衣原体抗原的DNA

使用BamHI、BglII、BstYi和MboI限制性酶，通过有限消化构建沙眼衣原体LGV II的基因组文库。随后将限制性消化的片断连接在逆转录病毒pBIB-KS1，2，3的BamHI位点中。该组载体经修饰含有Kosak翻译起始位点和终止位点，以致可允许从短DNA基因组片断表达蛋白质，见图2所示。制备80个克隆的DNA库，用其转染逆转录病毒包装细胞系Phoenix-Ampho，参见Pear，W.S.，Scott，M.L.和Nolan，G.P.，通过瞬时转染制备高滴度无辅助病毒的逆转录病毒，《分子医学方法：基因治疗方案》(Methods in Molecular Medicine：Gene TherapyProtocols)，Humana Press，Totowa，N.J.，pp.41-57。然后以逆转录病毒形式将衣原体文库转导至表达H2-Ld的P815细胞中，然后将此细胞用作靶细胞以刺激抗原特异性T细胞系。

按Starnbach，M.，J.Immunol.153：5183，1994描述的方法，用辐射过的沙眼衣原体感染的J774细胞和辐射过的同基因脾细胞重复多次刺激衣原体特异性小鼠H2^d限制性CD8+T细胞系，以培养扩增该细胞系。使用该衣原体特异性T细胞系筛选由逆转录病毒转导的P815细胞表达的上述衣原体基因组文库。通过使用Elispot分析(见Lalvani等，J.Experimental Medicine 186：859-865，1997)检测IFN-γ的产生，鉴定阳性DNA库。

IFN-γ Elispot分析中鉴定到两个阳性库，称作2C7和2E10。通过有限稀释克隆来自2C7库的P815细胞的稳定转导体，基于从衣原体特异性CTL细胞系引起IFN-γ产生的能力筛选各个克隆。由此筛选方法选择到4个阳性克隆，称作2C7-8，2C7-9，2C7-19和2C7-21。类似地，还筛选了阳性库2E10，导致获得含有3个插入片断的另一阳性克隆。这3个插入片断是CT016，tRNA合成酶和clpX基因的片断(分别是SEQ ID NO：268-270)。

使用pBIB-KS特异性引物PCR扩增来自这4个阳性2C7克隆的转基因DNA，以选择性地扩增衣原体DNA插入片断。凝胶纯化并测序扩增的插入片断。一个免疫反应性克隆2C7-8(SEQ ID NO：15，相应的预测氨基酸序列提供在SEQ ID NO：32中)是与沙眼衣原体血清变型D第597304-597145位核苷酸(NCBI，BLASTN检索；SEQ ID NO：33，预测的氨基酸序列提供在SEQ ID NO：34中)同源的一段160bp片断。克隆2C7-8的序列作图位于上面刚描述的高度同源区域中两个推测的开放阅读框之中，具体地，其中一个推测的开放阅读框由298个氨基酸的片断组成(SEQ ID NO：16，预测的氨基酸序列提供在SEQ ID NO：17中)，被证实表现出免疫活性。

使用5’-ttttgaagcaggtaggtgaatatg(正向)(SEQ ID NO：159)和5’-ttaagaaattaaaaaatccctta(反向)(SEQ ID NO：160)引物并使用纯化的沙眼衣原体L2基因组DNA作为模板，通过PCR扩增从血清变型L2获得该298个氨基酸片断的全长克隆(称作CT529和/或Cap1基因)。凝胶纯化该PCR产物，将其克隆至pCRBlunt(Invitrogen，Carlsbad，CA)进行测序，然后将其亚克隆至pBIB-KMS(pBIB-KS的衍生物)的EcoRI位点中进行表达。CT529的肺炎衣原体同系物提供在SEQID NO：291中，相应的氨基酸序列提供在SEQ ID NO：292中。

编码各种CT529血清变型的全长DNA基本上按Denamur，E.，C.Sayada，A.Souriau，J.Orfila，A.Rodolakis和J.Elion.1991.J.Gen.Microbiol.137：2525中所述通过PCR从含有10⁵IFU的细菌裂解物中扩增得到。按所述扩增了如下血清变型：Ba(SEQ ID NO：134，相应的预测氨基酸序列见SEQ ID NO：135)；E(BOUR)和E(MTW447)(SEQ ID NO：122，相应的预测氨基酸序列见SEQ ID NO：123)；F(NI1)(SEQ ID NO：128，相应的预测氨基酸序列见SEQ ID NO：129)；G；(SEQID NO：126，相应的预测氨基酸序列见SEQ ID NO：127)；Ia(SEQ IDNO：124，相应的预测氨基酸序列见SEQ ID NO：125)；L1(SEQ ID NO：130，相应的预测氨基酸序列见SEQ ID NO：131)；L3(SEQ ID NO：132，相应的预测氨基酸序列见SEQ ID NO：133)；I(SEQ ID NO：263，相应的预测氨基酸序列见SEQ ID NO：264)；K(SEQ ID NO：265，相应的预测氨基酸序列见SEQ ID NO：266)；和MoPn(SEQ ID NO：136，相应的预测氨基酸序列见SEQ ID NO：137)。用Advantage Genomic PCR试剂盒(Clontech，Palo Alto，CA)和特异针对血清变型L2 DNA(ORF外部)的引物进行PCR反应。除了MoPn需要5’-ttttgaagcaggtaggtgaatatg(正向-SEQ ID NO：163)和5’-tttacaataagaaaagctaagcactttgt(反向-SEQ ID NO：164)外，其余引物序列是5’-ggtataatatctctctaaattttg(正向-SEQ ID NO：161)和5’-agataaaaaaggctgtttc’(反向-SEQ ID NO：162)。用QIAquickPCR纯化试剂盒(Qiagen，Valencia，Calif.)纯化PCR扩增的DNA，将其克隆在pCR2.1(Invitrogen，Carlsbad，Calif.)中用于测序。

在自动测序仪(ABI 377)上使用pBIB-KS特异性正向引物5’-ccttacacagtcctgctgac(SEQ ID NO：165)和反向引物3’-gtttccgggccctcacattg(SEQ ID NO：166)两者测序来源于PCR扩增的免疫反应性克隆的插入片断。编码CT529血清变型L2的PCRBlunt克隆的DNA和编码CT529血清变型Ba，E(BOUR)，E(MTW447)，F(NI1)，G，Ia，K，L1，L3和MoPn的pCR2.1克隆DNA使用T7启动子引物和通用M13正向和M13反向引物测序。

为了确定这两个推测的开放阅读框(SEQ ID NO：16和20)是否编码具有相关的免疫学功能的蛋白质，按实施例3所述合成横跨这两段开放阅读框的重叠肽(17-20个氨基酸长度)。利用标准铬释放试验确定肽脉冲的H2^d限制性靶细胞的特异性裂解百分数。在此试验中，用100μCi ⁵¹Cr在有或无1μg/ml指定肽时37℃标记P815细胞(H2^d)等分试样1小时。孵育后，洗涤标记的P815细胞以除去多余的⁵¹Cr和肽，随后将细胞一式两份地铺在微量培养板中，浓度为1,000个细胞/孔。按指定的效应细胞：靶细胞比率加入效应CTL(衣原体特异性CD8 T细胞)。4小时孵育后，收获上清液并通过对释放至上清液中的⁵¹Cr的γ计数进行测量。来自298氨基酸开放阅读框的两个重叠肽特异地刺激CTL系。合成SEQ ID NO：138-156代表的肽，其是血清变型D的CT529开放阅读框(Cap1基因)和216个氨基酸开放阅读框的L2同系物的翻译物。如图3所示，在效应细胞与靶细胞比例为10∶1时，肽CtC7.8-12(SEQ ID NO：18，又称作Cap1#132-147，SEQ ID NO：139)和CtC7.8-13(SEQ ID NO：19，又称作Cap1#138-155，SEQ ID NO：140)能够分别引起38至52％的特异性裂解。值得注意的是，这两个肽的重叠部分含有一个预测的H2^d(K^d和L^d)结合肽。合成对应于此重叠序列(SEQ IDNO：31)的10个氨基酸的肽，在elispot试验中发现此肽可造成抗衣原体CTL细胞系的强免疫应答。有意义的是，对最近Genbank数据库的检索显示先前没有该基因的蛋白质的描述。因此，编码该推测的开放阅读框的克隆2C7-8(SEQ ID NO：15)定义了一个包含能够以MHC-I限制性方式刺激抗原特异性CD8+T细胞的衣原体抗原的基因，这说明该抗原能够用于开发抗衣原体的疫苗。

为了验证这些结果和进一步对该表位进行作图，制备截短的肽(SEQ ID NO：138-156)并在IFN-g ELISPOT试验中测试T细胞对它的识别。Ser139(Cap1#140-147，SEQ ID NO：146)或Leu147(Cap1#138-146，SEQ ID NO：147)的截短将废除T细胞识别。这些结果指示，9残基肽Cap1#139-147(SFIGGITYL，SEQ ID NO：145)是衣原体特异性T细胞识别的最小表位。

对所选沙眼衣原体血清变型(SEQ ID NO：121，123，125，127，129，131，133，135，137和139)的Cap1(CT529)的序列比对显示，其中一个氨基酸差异出现在所建议表位的2位。同源血清变型D肽是SIIGGITYL(SEQ ID NO：168)。比较SFIGGITYL和SIIGGITYL使细胞成为衣原体特异性T细胞识别目标的能力。每个肽的系列稀释物和P815细胞一起孵育，并在上述⁵¹Cr释放试验中测试T细胞对它们的识别。衣原体特异性T细胞可以识别最低浓度1nM的血清变型L2肽和最低浓度10nM的血清变型D肽。

进一步的研究显示，Cap1#139-147特异性T细胞克隆识别沙眼衣原体感染的细胞。为了验证Cap1_139-147是否被呈递在衣原体感染细胞表面上，用沙眼衣原体血清变型L2感染Balb-3T3(H-2^d)细胞并对其进行测试以确定这些细胞是否可以被Cap1#139-147表位(SEQ ID NO：145)特异性CD8+T细胞克隆识别。Cap1#139-147表位特异性T细胞克隆是通过有限稀释69 T细胞系获得的。该T细胞克隆特异识别衣原体感染细胞。在这些实验中，靶细胞是沙眼衣原体感染的(阳性对照)或未感染的Balb/3T3细胞，在30∶1、10∶1和3∶1效应细胞与靶细胞比例下它们分别显示出45％，36％和30％的特异裂解；或是Cap1#139-147表位(SEQ ID NO：145)包被的或未处理的P815细胞，在30∶1、10∶1和3∶1效应细胞与靶细胞比例下它们分别显示出83％，75％和58％的特异裂解(在所有的情况下阴性对照具有小于5％的裂解)。该数据提示，该表位在感染期间被呈递。

体内研究显示Cap1#139-147表位特异性T细胞在小鼠感染沙眼衣原体期间被致敏。为了确定沙眼衣原体感染是否引发Cap1#139-147表位特异性T细胞应答，用10⁸IFU沙眼衣原体血清变型L2腹膜内注射小鼠。注射后两周，处死小鼠，脾细胞在辐射过的经Cap1#139-147表位肽脉冲的同基因脾细胞上进行刺激。刺激5天后，在标准⁵¹Cr释放试验中使用培养物确定培养物中是否存在Cap1#139-147表位特异性T细胞。具体地，来自沙眼衣原体血清变型L2免疫过的小鼠或注射PBS的对照小鼠的脾细胞在与Cap1#139-147肽包被的同基因脾细胞一起培养5天后和能够特异识别Cap1#139-147表位的CD8+T细胞在30∶1、10∶1和3∶1效应细胞和靶细胞比例下分别给出73％、60％和32％特异裂解。对照小鼠在30∶1效应细胞和靶细胞比例下给出大约10％的裂解百分数，并随着效应细胞∶靶细胞比例的降低稳定地下降。靶细胞是Cap1#139-147肽包被的或未处理的P815细胞。这些数据提示，Cap1#139-147肽特异性T细胞在小鼠感染沙眼衣原体期间被致敏。

Ct529定位

经研究证明Ct529(这里称作Cap-1)定位在沙眼衣原体感染细胞的包含体膜(inclusion membrane)上，与原生小体或网状体(reticulate body)无关。如上述，Cap-1被鉴定为可以刺激CD8+CTL的来自衣原体的产物。这些CTL在小鼠感染模型中具有保护性，由此使得Cap-1成为良好的疫苗候选者。而且，由于这些CTL是MHC-1限制性的，该Cap-1基因必定可以达到感染细胞的细胞质，这可能是特定衣原体基因产物的独特特征。因此，确定该基因产物的细胞定位对于表征Cap-1作为疫苗候选者是有用的。为了检测Cap-1的细胞内定位，使用抗包括Cap-1 N端125个氨基酸(SEQ ID NO：305，包括N端6-His标签的氨基酸序列提供在SEQ ID NO：304中)的重组多肽的兔多克隆抗体染色衣原体感染的McCoy细胞。

用重组多肽rCt529cl-125(SEQ ID NO：305)(包括Cap-1的N端部分)超免疫兔，获得兔抗Cap-1多克隆抗体。从pET表达质粒(见上述)转化的大肠杆菌获得重组rCt529cl-125蛋白质，其中所述质粒含有编码Cap-1 N端第1-125位氨基酸的第1-375位核苷酸。使用本领域熟知技术通过Ni-NTA纯化重组蛋白。对于阳性对照抗血清，通过用纯化的沙眼衣原体原生小体(Biodesign，Sacco，Maine)免疫兔制备抗原生小体的多克隆抗血清。来源于Cap-1多肽免疫前的兔子的免疫前血清被用作阴性对照。

在生长在盖玻片上、并以10⁶IFU(Inclusion Forming Units，包含体形成单位)/ml的浓度接种了沙眼衣原体血清变型L2或鹦鹉热衣原体(C.psitacci)株6BC的McCoy细胞单层上进行免疫细胞化学试验。2小时后，吸去培养基，更换为新鲜补加了放线菌酮(1.0μg/ml)的RP-10培养基。在7％CO₂中孵育感染细胞24小时，然后通过吸去培养基、用PBS洗涤细胞一次然后甲醇固定5分钟实现对感染细胞的固定。为了进行抗原染色，用PBS洗涤固定的细胞单层，然后和1∶100稀释的特异或对照抗血清37℃孵育2小时。用PBS洗涤细胞，并与荧光素异硫氰酸酯(FITC)标记的抗兔IgG(KPL，Gaithersburg)孵育1小时，然后用PBS中的伊文思蓝(Evans blue)(0.05％)染色。用100×物镜(Zeiss落射荧光显微镜)观察荧光并照相(Nikon UFX-11A照相机)。

该研究的结果显示，Cap-1位于沙眼衣原体感染细胞的包含体膜上。Cap-1特异性抗体标记沙眼衣原体感染细胞的包含体膜，但不标记包含在这些包含体中的或固定过程中释放的衣原体原生小体。相反地，抗原生小体的抗体清楚地标记该细菌体，这不仅包括包含体中的原生小体还有固定过程中释放的原生小体。抗Cap-1抗体的特异性可由如下事实证明，即该抗体不染色鹦鹉热衣原体感染的细胞。该Cap-1标记的特异性也可以通过免疫前血清中缺少反应性来证实。这些结果提示，Cap-1从细菌中释放出来，并与衣原体包含体膜结合。因此，在开发抗衣原体感染的疫苗时Cap-1是可以用于刺激CD8+T细胞的基因产物。

另两个系列研究进一步说明在抗衣原体感染的疫苗中Cap-1基因作为潜在的CTL抗原的重要意义。首先，对沙眼衣原体Cap-1 CT529#138-147肽的MHC-I表位(SEQ ID NO：144)具有特异性的CTL被证实可以在自然感染过程中被高频率致敏。具体地，用10⁶I.F.U.沙眼衣原体血清变型L2接种Balb/C小鼠。2周后，收获脾脏，并通过Elispot分析定量响应Cap-1#138-147肽脉冲的抗原呈递细胞而分泌IFN-γ的细胞的数量。在两个实验中，10⁵个脾细胞中的IFN-γ分泌细胞的数量为全部CD8+T细胞的大约1％。使CD8+CTL响应MHC-1表位(Cap-1CT529#138-147肽)的这种高频率提示Cap-1在感染中具有高免疫原性。

第二个系列研究的结果显示，Cap-1蛋白在感染后几乎立即可以达到宿主细胞的细胞质。这可以由Cap-1 CT529#138-147肽呈递的时程来证实。简而言之，用沙眼衣原体血清变型L2感染3T3细胞不同的时间长度，然后测试Cap-1 CT529#138-147肽特异性CTL的识别。结果显示，沙眼衣原体感染的3T3细胞在仅2小时感染后就可以被抗原特异性CTL靶向识别。这些结果提示，Cap-1是在沙眼衣原体原生小体向网状体发育的过程中合成的早期蛋白。在抗衣原体感染的疫苗中，针对感染早期表达的基因产物的CD8+CTL免疫应答可能是尤其有效的。

实施例5

在衣原体抗原免疫的小鼠中抗体和T细胞应答的产生

我们进行了免疫原性研究，以确定使用Montanide佐剂配制的纯化的SWIB或S13蛋白质、或用含有SWIB或S13的DNA序列的pcDNA-3表达载体(基于DNA的免疫)免疫的小鼠的抗体和CD4+T细胞应答。SWIB也称作克隆1-B1-66(SEQ ID NO：1，相应的氨基酸序列提供在SEQ ID NO：5中)，而S13核糖体蛋白又称作克隆10-C10-31(SEQ IDNO：4，相应的氨基酸序列提供在SEQ ID NO：12中)。在第一个实验中，对3只C57BL/6小鼠组成的若干组免疫两次并监测其抗体和CD4+T细胞应答。DNA免疫在尾的基部皮内进行，肽免疫通过皮下途径给药。来自免疫小鼠的脾细胞的标准3H-掺入试验的结果显示用纯化的重组SWIB多肽(SEQ ID NO：5)免疫的组产生强增殖应答。按前述，用细胞因子诱导试验进行的进一步分析证明，SWIB多肽免疫的组产生可检测的IFN-γ和IL-4应答。随后进行了基于ELISA的试验，以确定用SWIB多肽免疫的实验组中的主要抗体同种型应答。图4说明，SWIB免疫组给出了以IgG1为主的体液应答。

在第二个实验中，用配制在PBS或Montanide中的10μg纯化的SWIB蛋白质(又称作克隆1-B1-66，SEQ ID NO：5)以3周为间隔免疫C3H小鼠3次，第三次免疫后两周收获细胞。通过本领域熟知的基于ELISA的标准技术测定抗SWIB蛋白质的抗体效价，证明配制在Montanide中的SWIB蛋白诱导强的体液免疫应答。通过基于XTT的试验(Scudiero等，Cancer Research，1988，48：4827)测定T细胞增殖应答。如图5所示，来自SWIB多肽加Montanide免疫的小鼠的脾细胞引起抗原特异性增殖应答。此外，使用先前描述的细胞因子诱导试验确定来自免疫动物的脾细胞响应可溶性重组SWIB多肽分泌IFN-γ的能力。来自用Montanide佐剂配制的SWIB多肽免疫的动物组的所有动物的脾细胞均响应SWIB衣原体抗原接触而分泌IFN-γ，说明此是衣原体特异性免疫应答。

在另一实验中，C3H小鼠在三个不同的时间点上在尾的基部接受配制在SBAS2佐剂(SmithKline Beecham，伦敦，英国)中的10μg纯化的SWIB或S13蛋白质(沙眼衣原体，SWIB蛋白，克隆1-B1-66，SEQ IDNO：5，和S13蛋白质，克隆10-C10-31，SEQ ID NO：4)的免疫。通过ELISA测定抗原特异性抗体效价，显示两种多肽均诱导强的IgG应答，效价从1×10^-4至1×10^-5。该应答的IgG1和IgG2a成分以相当等同的量存在。针对SWIB的抗原特异性T细胞增殖应答(通过在分离自免疫小鼠的脾细胞上进行的标准³H掺入试验确定的)十分强(比阴性对照高50,000cpm)，而针对S13的应答甚至更强(比阴性对照高100,000cpm)。通过标准ELISA技术从来自增殖培养物的上清液分析IFNγ的产生。用S13体外重复刺激该培养物诱导了高水平的IFNγ产生，大约是25ng/ml对阴性对照的2ng/ml用SWIB蛋白进行重复刺激也诱导了IFNγ，但程度较小。

在相关实验中，C3H小鼠在三个不同的时间点上接受与10μg霍乱毒素混合的10μg纯化的SWIB或S13蛋白质(沙眼衣原体，SWIB蛋白，克隆1-B1-66，SEQ ID NO：5，和S13蛋白质，克隆10-C10-31，SEQID NO：4)的免疫。通过鼻内接种进行粘膜免疫。利用标准ELISA技术测定抗原特异性抗体应答。SWIB免疫小鼠的血液中存在抗原特异性IgG抗体，效价为1×10^-3至1×10^-4，但在S13免疫的动物中不能检测到。按IFNγ的产生测量，分离的脾细胞的抗原特异性T细胞应答给出与上文刚描述的全身免疫得到的结果相似的结果。

为了确定CT529血清变型LGVII CTL表位的免疫原性，进行了动物研究，其中所述表位由确定为H2-Kd限制性CTL表位的CT529 10mer共有序列肽(CSFIGGITYL-SEQ ID NO：31)定义。用25μg肽联合不同的佐剂免疫BALB/c小鼠(每组3只小鼠)3次。在尾的基部系统施用SKB佐剂系统SBAS-2”、SBAS-7(SmithKline Beecham，伦敦，英国)或Montanide中的肽。还鼻内施用与10μg霍乱毒素(CT)混合的肽。使用自然小鼠(naive mice)作为对照。第3次免疫后4周，用10μg/mlCT529 10残基共有序列肽脉冲的LPS母细胞(LPS-blasts)以3个不同的效应细胞比LPS母细胞比例(6、1.5和0.4)按1×10⁶个细胞/ml重复刺激脾细胞。2次重复刺激后，使用标准铬释放试验，检测效应细胞裂解肽脉冲的P815细胞的能力。使用来自鸡卵卵清蛋白的无关肽作为阴性对照。结果证明，引起了针对该CT52910残基共有序列肽的显著免疫应答，而且响应用该肽进行的免疫引起了能够裂解肽脉冲的靶标的抗原特异性T细胞。具体地，发现在SBAS-7和CT佐剂组中存在抗原特异性裂解活性，而Montanide和SBAS-2”不能辅助此CTL表位免疫。

实施例6

肺炎衣原体基因的表达和表征

实施例1描述的人T细胞系TCL-8识别沙眼衣原体和肺炎衣原体感染的单核细胞来源的树突细胞，提示沙眼衣原体和肺炎衣原体可能编码交叉反应性T细胞表位。为了分离与沙眼衣原体LGVII克隆1B1-66(又称作SWIB，SEQ ID NO：1)和克隆10C10-31(又称作S13核糖体蛋白，SEQ ID NO：4)同源的肺炎衣原体基因，用肺炎衣原体TWAR株(CDC/CWL-029)感染HeLa229细胞。孵育3天后，收获肺炎衣原体感染的HeLa细胞，洗涤并重悬在200μl水中，然后在沸水浴中加热20分钟。使用破裂的细胞悬浮液10μl作为PCR模板。

设计针对克隆1B1-66和10C10-31的肺炎衣原体特异性引物，以便5’末端具有一个6×组氨酸标签和插入的一个NdeI位点，而3’末端具有一个终止密码子并包括一个BamHI位点(图6)。通过本领域熟知的标准技术，扩增并测序PCR产物。将肺炎衣原体特异性PCR产物克隆至表达载体pET17B(Novagen，Madison，WI)中，并转染大肠杆菌BL21 pLysS以便实现表达和随后利用组氨酸-镍亲和层析方法学(Novagen提供)进行的纯化。由此产生肺炎衣原体两个蛋白质，一个10-11kDa蛋白质，称作CpSWIB(分别是SEQ ID NO：27，和具有6×His标签的SEQ ID NO：78，相应的氨基酸序列提供在SEQ ID NO：28中)，一个15kDa蛋白质，称作CPS13(SEQ ID NO：29，和具有6×His标签的SEQ ID NO：77，相应的氨基酸序列分别提供在SEQ ID NO：30和91中)。

实施例7

肺炎衣原体抗原对T细胞增殖和干扰素-γ产生的诱导

重组肺炎衣原体抗原诱导T细胞增殖和干扰素-γ产生的能力按如下进行确定。

通过IPTG诱导蛋白质，并通过Ni-NTA琼脂糖亲和层析(Webb等，J.Immunology 157：5034-5041，1996)进行纯化。然后根据诱导PBMC制品中T细胞增殖的能力筛选纯化的多肽。将来自肺炎衣原体患者以及来自其T细胞已知可以响应衣原体抗原发生增殖的正常供体的PBMC培养在含有补加了10％汇合的人血清和50μg/ml庆大霉素的RPMI1640的培养基中。一式两份地以0.5至10μg/ml的浓度加入纯化的多肽。在96孔圆底平板中以200μl体积培养6天后，从每个孔中取出50μl培养基用于确定IFN-γ的水平，如下述。然后用1μCi/孔氚化胸苷脉冲平板再18个小时，收获细胞然后使用气体闪烁计数器测定氚的摄取。在重复试验中导致细胞增殖达到在单纯培养基培养的细胞中观察到的增殖的3倍以上的组分被认为是阳性的。

使用酶联免疫吸附测定方法(ELISA)测定IFN-γ。室温用抗人IFN-γ的小鼠单克隆抗体(PharMingen，San Diego，CA)在PBS中包被ELISA平板4小时。然后用含有5％(w/v)脱脂干奶粉的PBS室温封闭孔1小时。在PBS/0.2％Tween-20中洗涤平板6次，然后在ELISA平板中室温过夜孵育培养基中1∶2稀释的样品。再次洗涤平板，并在每孔中加入PBS/10％正常山羊血清中1∶3000稀释的多克隆兔抗人IFN-γ血清。然后，室温孵育平板2小时，洗涤平板后加入PBS/5％脱脂干奶粉中1∶2000稀释的辣根过氧化物酶偶联的抗兔IgG(Sigma Chemical So.，St.Louis，MO)。室温再孵育两小时后，洗涤平板并加入TMB底物。20分钟后用1N硫酸终止反应。使用570nm作为参考波长在450nm测定光密度。在两次重复试验中均导致产生的OD比单纯培养基中培养的细胞的平均OD加上3个标准差大两倍的组分被认为是阳性的。

能够和沙眼衣原体和肺炎衣原体交叉反应的人抗衣原体T细胞系(TCL-8)被用于确定上述实施例中描述的表达蛋白(即，CpSWIB，SEQ IDNO：27，和具有6×His标签的SEQ ID NO：78，相应的氨基酸序列提供在SEQ ID NO：28中；和称作CpS13的15kDa蛋白质，SEQ ID NO：29，和具有6×His标签的SEQ ID NO：77，相应的氨基酸序列分别提供在SEQ ID NO：30和91中)是否具有沙眼衣原体和肺炎衣原体共有的T细胞表位。简而言之，在1×10⁴个单核细胞来源的树突细胞上滴定表达衣原体抗原的大肠杆菌。2小时后，洗涤树突细胞培养物，并加入2.5×10⁴个T细胞(TCL-8)，再孵育72小时。然后通过ELISA确定培养物上清液中的IFN-γ量。如图7A和7B所示，TCL-8 T细胞系特异地识别沙眼衣原体和肺炎衣原体两者的S13核糖体蛋白质，正如通过IFN-γ的抗原特异性诱导所证明的那样，而该T细胞系仅识别来自沙眼衣原体的SWIB蛋白。为了验证这些结果，使用经一系列重叠肽脉冲的靶细胞和T细胞系TCL-8，通过表位作图鉴定沙眼衣原体SWIB的T细胞表位。3H-胸苷掺入试验显示，称作C.t.SWIB52-67的肽(SEQID NO：39)造成了TCL-8细胞系的最强增殖。合成相应于肺炎衣原体的SWIB序列(SEQ ID NO：40)、肺炎衣原体(SEQ ID NO：43)和沙眼衣原体(SEQ ID NO：42)的拓扑异构酶-SWIB融合物、以及人SWI域(SEQID NO：41)的同源肽，并在上述试验中对它们进行测试。T细胞系TCL-8仅识别SEQ ID NO：39的沙眼衣原体肽而不识别相应的肺炎衣原体肽(SEQ ID NO：40)或上述其它相应肽(SEQ ID NO：41-43)。

通过用沙眼衣原体或肺炎衣原体感染的单核细胞来源的树突细胞分别刺激供体PBMC，从具有抗肺炎衣原体的阳性血清效价的供体CP-21产生衣原体特异性T细胞系。抗肺炎衣原体产生的T细胞应答重组肺炎衣原体SWIB但不应答沙眼衣原体SWIB，而抗沙眼衣原体产生的T细胞对沙眼衣原体或肺炎衣原体的SWIB均不产生应答(见图9)。供体CP-21的肺炎衣原体SWIB特异性免疫应答证实了存在肺炎衣原体感染，并指示在体内肺炎衣原体感染期间引起了肺炎衣原体SWIB特异性T细胞。

对肺炎衣原体SWIB的T细胞应答的表位作图显示，Cp-SWIB特异性T细胞应答重叠肽Cp-SWIB32-51(SEQ ID NO：101)和Cp-SWIB 37-56(SEQ ID NO：102)，从而指示了肺炎衣原体SWIB特异性T细胞表位Cp-SWIB 37-51(SEQ ID NO：100)。

在其它实验中，通过用来自沙眼衣原体和肺炎衣原体的非感染性原生小体分别刺激PBMC，从供体CP1(也是肺炎衣原体血清阳性供体)制备T细胞系。具体地，在存在1×10⁴个单核细胞来源的树突细胞和来源于沙眼衣原体和肺炎衣原体的非感染性原生小体，或存在重组沙眼衣原体或肺炎衣原体SWIB蛋白的情况下刺激2.5×10⁴个T细胞，以测定增殖应答。抗SWIB的T细胞应答与使用来自CP-21的T细胞系获得的数据在以下方面相似：引起肺炎衣原体T细胞系应答的是肺炎衣原体SWIB而非沙眼衣原体SWIB。此外，该沙眼衣原体T细胞系不能应答沙眼衣原体或肺炎衣原体SWIB产生增殖，但其确实应答CT和CP原生小体发生增殖。如实施例1所述，使用TCP-21细胞系鉴定的克隆11-C12-91(SEQ ID NO：63)具有269bp插入片断，其是OMP2基因(CT443)的一部分并与肺炎衣原体60kDa富含半胱氨酸的外膜蛋白质(称作OMCB)具有同源性。为了进一步确定该反应性表位，使用一系列重叠肽和前述免疫测定方法进行表位作图。简而言之，在1×10⁴个单核细胞来源的树突细胞存在时用来源于沙眼衣原体和肺炎衣原体的非感染性原生小体或来源于沙眼衣原体或肺炎衣原体OMCB蛋白的蛋白质序列的肽(0.1μg/ml)刺激2.5×10⁴个TCP-21 T细胞，以测定增殖应答。TCP-21 T细胞应答表位CT-OMCB#167-186、CT-OMCB#171-190、CT-OMCB#171-186，并以较小的程度应答表位CT-OMCB#175-186(分别是SEQ ID NO：249-252)。值得注意的是，TCP-21 T细胞系还响应同源肺炎衣原体肽CP-OMCB#171-186(SEQ ID NO：253)产生增殖应答，该应答的程度与响应沙眼衣原体肽的应答程度相比是相同的或更大。在2位(即，Asp替换为Glu)和4位(即，Cys替换为Ser)的氨基酸替换均不改变T细胞的增殖应答，由此说明该表位是沙眼衣原体和肺炎衣原体之间的交叉反应性表位。

实施例8

人PBMC和T细胞系对衣原体抗原的免疫应答

这里提供的实施例提示，在已经感染沙眼衣原体并产生了控制该沙眼衣原体感染的保护性免疫应答的一般群体中存在一个健康供体群。这些供体在临床上是无症状的，并是沙眼衣原体血清阴性的。为了表征正常供体对通过CD4表达克隆鉴定的衣原体抗原产生的免疫应答，检测从12名健康供体获得的PBMC对一组重组衣原体抗原(包括沙眼衣原体SWIB、肺炎衣原体SWIB及沙眼衣原体S13、肺炎衣原体S13)的反应。数据总结在下表I中。所有供体均是沙眼衣原体血清阴性的，而6/12具有阳性肺炎衣原体效价。使用＞4的刺激指数作为阳性应答，11/12受试者对沙眼衣原体原生小体产生应答而12/12对肺炎衣原体原生小体产生应答。一个供体，AD104，应答重组肺炎衣原体S13蛋白，但不应答重组沙眼衣原体S13蛋白，这说明此是肺炎衣原体特异性应答。12个供体中有3个具有沙眼衣原体SWIB而非肺炎衣原体SWIB特异性应答，从而证实为沙眼衣原体感染。沙眼衣原体和肺炎衣原体S13在8/12供体中引起应答，提示为衣原体感染。这些说明阐明了SWIB和S13在正常研究对象的PBMC中引起T细胞应答的能力。

表I

正常研究对象对衣原体的免疫应答

供体	性别	衣原体IgG效价	CTEB	CPEB	CTSwib	CPSwib	CTS13	CPS13	CTIpdA	CTTSA
供体	性别	衣原体IgG效价	CTEB	CPEB	CTSwib	CPSwib	CTS13	CPS13	CTIpdA	CTTSA	AD100	男	阴性	++	+++	+	-	++	++	-	n.t.
AD104	女	阴性	+++	++	-	-	-	++	-	n.t.	AD100	男	阴性	++	+++	+	-	++	++	-	n.t.
AD104	女	阴性	+++	++	-	-	-	++	-	n.t.	AD108	男	CP1：256	++	++	+	+/-	+	+	+	n.t.
AD112	女	阴性	++	++	+	-	+	-	+/-	n.t.	AD108	男	CP1：256	++	++	+	+/-	+	+	+	n.t.
AD112	女	阴性	++	++	+	-	+	-	+/-	n.t.	AD120	男	阴性	-	+	-	-	-	-	-	n.t.
AD124	女	CP1：128	++	++	-	-	-	-	-	n.t.	AD120	男	阴性	-	+	-	-	-	-	-	n.t.
AD124	女	CP1：128	++	++	-	-	-	-	-	n.t.	AD128	男	CP1：512	+	++	-	-	++	+	++	-
AD132	女	阴性	++	++	-	-	+	+	-	-	AD128	男	CP1：512	+	++	-	-	++	+	++	-
AD132	女	阴性	++	++	-	-	+	+	-	-	AD136	女	CP1：128	+	++	-	-	+/-	-	-	-
AD140	男	CP1：256	++	++	-	-	+	+	-	-	AD136	女	CP1：128	+	++	-	-	+/-	-	-	-
AD140	男	CP1：256	++	++	-	-	+	+	-	-	AD142	女	CP1：512	++	++	-	-	+	+	+	-
AD146	女	阴性	++	++	-	-	++	+	+	-	AD142	女	CP1：512	++	++	-	-	+	+	+	-

CT＝沙眼衣原体；CP＝肺炎衣原体；EB＝衣原体原生小体；Swib＝重组衣原体Swib蛋白；S13＝重组衣原体S13蛋白；lpdA＝重组衣原体lpdA蛋白；TSA＝重组衣原体TSA蛋白。数值表示从标准增殖试验得到的结果。通过用预先和各个重组抗原或原生小体(EB)一起孵育过的1×10⁴个单核细胞来源的树突细胞刺激3×10⁵PBMC，测定增殖应答。6天后用³H-胸苷脉冲最后的18小时，收获试验结果。

SI：刺激指数

～/-： SI～ 4

+： SI＞ 4

++： SI 10-30

+++： SI＞ 30

在第一个系列的实验中，按前述通过用沙眼衣原体LGV II原生小体刺激T细胞从生殖道曾经接触过沙眼衣原体的健康女性个体(CT-10)制备T细胞系。尽管研究对象曾接触过沙眼衣原体，但她没有发生血清转化，也没有出现临床症状，这提示供体CT-10可能已经发展了抗沙眼衣原体的保护性免疫应答。如图10所示，来源于供体CT-10的原代衣原体特异性T细胞系可对沙眼衣原体SWIB而非肺炎衣原体SWIB重组蛋白产生应答，这证实了CT-10接触过沙眼衣原体。对沙眼衣原体SWIB的T细胞应答的表位作图显示，该供体与T细胞系TCL-8一样对相同表位Ct-SWIB 52-67(SEQ ID NO：39)产生应答，见图11所示。

按上述产生针对不同沙眼衣原体患者的其它T细胞系。患者的临床概况和对多种沙眼衣原体和肺炎衣原体原生小体及重组蛋白的增殖应答总结在下表II中：

沙眼衣原体患者的增殖应答
沙眼衣原体患者的增殖应答											患者	临床表现	IgG效价	CTEB	CPEB	CTSwib	CPSwib	CTS13	CPS13	CTlpdA	CTTSA
CT-1	NGU	阴性	+	+	-	-	++	++	++	+	患者	临床表现	IgG效价	CTEB	CPEB	CTSwib	CPSwib	CTS13	CPS13	CTlpdA	CTTSA
CT-1	NGU	阴性	+	+	-	-	++	++	++	+	CT-2	NGU	阴性	++	++	-	-	+	+/-	-	-
CT-3	无症状排出EbDx是HPV	Ct1：512Cp1：1024Cps1：256	+	+	-	-	+	-	+	-	CT-2	NGU	阴性	++	++	-	-	+	+/-	-	-
CT-3	无症状排出EbDx是HPV	Ct1：512Cp1：1024Cps1：256	+	+	-	-	+	-	+	-	CT-4	无症状排出Eb	Ct1：1024	+	+	-	-	-	-	-	-
CT-5	BV	Ct1：256Cp1：256	++	++	-	-	+	-	-	-	CT-4	无症状排出Eb	Ct1：1024	+	+	-	-	-	-	-	-
CT-5	BV	Ct1：256Cp1：256	++	++	-	-	+	-	-	-	CT-6	会阴疹流出物	Cp1：1024	+	+	-	-	-	-	-	-
CT-7	BV生殖器溃疡	Ct1：512Cp1：1024	+	+	-	-	+	+	+	-	CT-6	会阴疹流出物	Cp1：1024	+	+	-	-	-	-	-	-
CT-7	BV生殖器溃疡	Ct1：512Cp1：1024	+	+	-	-	+	+	+	-	CT-8	未知	未测	++	++	-	-	-	-	-	-
CT-9	无症状	Ct1：128Cp1：128	+++	++	-	-	++	+	+	-	CT-8	未知	未测	++	++	-	-	-	-	-	-
CT-9	无症状	Ct1：128Cp1：128	+++	++	-	-	++	+	+	-	CT-10	外阴中度搔痒	阴性	++	++	-	-	-	-	-	-
CT-11	BVpap异常	Ct1：512	+++	+++	-	-	+++	+/-	++	+	CT-10	外阴中度搔痒	阴性	++	++	-	-	-	-	-	-
CT-11	BVpap异常	Ct1：512	+++	+++	-	-	+++	+/-	++	+	CT-12	无症状	Cp1：512	++	++	-	-	++	+	+	-

NGU＝非淋球菌性尿道炎；BV＝细菌性阴道病；CT＝沙眼衣原体；CP＝肺炎衣原体；EB＝衣原体原生小体；Swib＝重组衣原体Swib蛋白；S13＝重组衣原体S13蛋白；lpdA＝重组衣原体lpdA蛋白；TSA＝重组衣原体TSA蛋白。数值表示从标准增殖试验得到的结果。通过用各个重组抗原或原生小体(EB)刺激3×10⁵PBMC，测定增殖应答。6天后用³H-胸苷脉冲最后的18小时，收获试验结果。

SI：刺激指数

+/-： SI～ 4

+： SI＞ 4

++： SI 10-30

+++： SI＞ 30

使用这些无症状(如上定义)研究对象和沙眼衣原体患者(总结在表I和II中)，全面研究了来源于两个组的PBMC的免疫应答。简而言之，将来自肺炎衣原体患者以及来自正常供体的PBMC培养在含有补加了10％汇合的人血清和50μg/ml庆大霉素的RPMI 1640的培养基中。一式两份地以0.5至10μg/ml的浓度加入纯化的多肽，即一组重组衣原体抗原，包括沙眼衣原体的和肺炎衣原体的SWIB和S13、以及沙眼衣原体lpdA和TSA。在96孔圆底平板中以200μl体积培养6天后，从每个孔中取出50μl培养基用于确定IFN-γ的水平，如下述。然后用1μCi/孔氚化胸苷脉冲平板再18个小时，收获细胞然后使用气体闪烁计数器测定氚的摄取。在重复试验中导致细胞增殖比在单纯培养基培养的细胞中观察到的增殖高3倍的组分被认为是阳性的。

对重组衣原体抗原的增殖应答证实，大多数无症状供体和沙眼衣原体患者识别沙眼衣原体S13抗原(8/12)，大多数沙眼衣原体患者识别肺炎衣原体S13抗原(8/12)，4/12的无症状也识别肺炎衣原体S13抗原。而且，12名沙眼衣原体患者中的6名以及12名无症状供体中的4名给出对沙眼衣原体lpdA抗原的增殖应答。这些结果说明，沙眼衣原体和肺炎衣原体S13抗原、沙眼衣原体Swib抗原和沙眼衣原体lpdA抗原均可被无症状供体识别，这表明在暴露于衣原体的过程这些抗原被识别并引起了对抗它们的免疫应答。这提示，这些抗原可能在赋予人类宿主保护性免疫方面有作用。此外，在沙眼衣原体患者中沙眼衣原体和肺炎衣原体S13抗原可以同样良好地被识别，由此说明沙眼衣原体和肺炎衣原体可能在S13蛋白中具有共同的表位。表III总结了这些研究的结果。

表III

抗原	正常供体	C.t.患者
抗原	正常供体	C.t.患者	C.t.-Swib	3/12	0/12
C.p.-Swib	0/12	0/12	C.t.-Swib	3/12	0/12
C.p.-Swib	0/12	0/12	C.t.-S13	8/12	8/12
C.p.-S13	4/12	8/12	C.t.-S13	8/12	8/12
C.p.-S13	4/12	8/12	lpdA	4/12	6/12
TSA	0/12	2/12	lpdA	4/12	6/12

我们开始了一系列研究以确定产生自无症状供体和沙眼衣原体患者的短期T细胞系的细胞免疫应答。通过标准增殖试验和IFN-γ(见实施例7所述)测量细胞免疫应答。具体地，大多数抗原采取表达衣原体抗原的单大肠杆菌克隆的形式，但在这些试验中还使用了一些重组蛋白质。在1×10⁴个单核细胞来源的树突细胞上滴定(titer)这些单大肠杆菌克隆，2小时后，洗涤培养物并加入2.5×10⁴个T细胞。使用重组蛋白进行的试验按前述方法进行。4天后用标准3H-胸苷脉冲最后的18小时，确定增殖情况。按上述，使用标准ELISA分析测定4天后收获的培养物上清液中的IFN-γ诱导情况。结果显示，测试的所有沙眼衣原体抗原除了C.T.Swib外均引起来源于沙眼衣原体患者的一个或多个不同T细胞系产生增殖应答。此外，如下衣原体基因也从沙眼衣原体患者和无症状供体引起了增殖应答：CT622、groEL、pmpD、CT610和rS13。

12G3-83克隆除了含有CT622外还含有CT734和CT764的序列，因此，这些基因序列可能也有免疫反应性表位。类似地，克隆21G12-60除了含有CT875外还含有假拟蛋白基因CT229和CT228的序列；而15H2-76还含有来自CT812和CT088以及与sycE基因具有同源性的序列。克隆11H3-61还含有与PGP6-D毒力蛋白质具有同源性的序列。

表IV

克隆	C.t.抗原(推测的^*)	来自无症状供体的TCL	来自C.t.患者的TCL	SEQ ID NO：
克隆	C.t.抗原(推测的^*)	来自无症状供体的TCL	来自C.t.患者的TCL	SEQ ID NO：	1B1-66(大肠杆菌)	Swib	2/2	0/4	5
1B1-66(蛋白质)	Swib	2/2	0/4	5	1B1-66(大肠杆菌)	Swib	2/2	0/4	5
1B1-66(蛋白质)	Swib	2/2	0/4	5	12G3-83(大肠杆菌)	CT622^*	2/2	4/4	57
22B3-53(大肠杆菌)	groEL	1/2	4/4	111	12G3-83(大肠杆菌)	CT622^*	2/2	4/4	57
22B3-53(大肠杆菌)	groEL	1/2	4/4	111	22B3-53(蛋白质)	groEL	1/2	4/4	111
15H2-76(大肠杆菌)	PmpD^*	1/2	3/4	87	22B3-53(蛋白质)	groEL	1/2	4/4	111
15H2-76(大肠杆菌)	PmpD^*	1/2	3/4	87	11H3-61(大肠杆菌)	rL1^*	0/2	3/4	60
14H1-4(大肠杆菌)	TSA	0/2	3/4	56	11H3-61(大肠杆菌)	rL1^*	0/2	3/4	60
14H1-4(大肠杆菌)	TSA	0/2	3/4	56	14H1-4(蛋白质)	TSA	0/2	3/4	56
11G10-46(大肠杆菌)	CT610	1/2	1/4	62	14H1-4(蛋白质)	TSA	0/2	3/4	56
11G10-46(大肠杆菌)	CT610	1/2	1/4	62	10C10-17(大肠杆菌)	rS13	1/2	1/4	62
10C10-17(蛋白质)	rS13	1/2	1/4	62	10C10-17(大肠杆菌)	rS13	1/2	1/4	62
10C10-17(蛋白质)	rS13	1/2	1/4	62	21G12-60(大肠杆菌)	CT875^*	0/2	2/4	110
11H4-32(大肠杆菌)	dnaK	0/2	2/4	59	21G12-60(大肠杆菌)	CT875^*	0/2	2/4	110
11H4-32(大肠杆菌)	dnaK	0/2	2/4	59	21C7-8(大肠杆菌)	dnaK	0/2	2/4	115
17C10-31(大肠杆菌)	CT858	0/2	2/4	114	21C7-8(大肠杆菌)	dnaK	0/2	2/4	115

实施例9

使用衣原体抗原进行的保护研究

1.SWIB

在小鼠中进行保护研究以确定用衣原体抗原免疫是否能够影响衣原体接种导致的生殖道疾病。利用两种模型：一种阴道内接种模型，使用含有鹦鹉热衣原体菌株(MTW447)的人分离菌；一种子宫内接种模型，涉及鉴定为沙眼衣原体血清变型F(NI1菌株)的人分离菌。两种菌株均引起上生殖道炎症，这类似沙眼衣原体在女性中引起的子宫内膜炎和输卵管炎。在第一个实验中，用100μg含有沙眼衣原体SWIBDNA(SEQ ID NO：1，相应的氨基酸序列提供在SEQ ID NO：5)的pcDNA-3表达载体3次免疫C3H小鼠(每组4只小鼠)。对于系统免疫，在尾的基部进行接种。最后一次免疫后2周，孕酮处理动物，并经过阴道或通过在子宫中注射接种物进行感染。感染后2周，处死小鼠，对生殖道进行切片、染色和组织病理学检查。对炎症水平进行评分(从+(十分轻微)至+++++(十分严重))。将各个输卵管/卵巢的得分加合起来然后除以检查的器官数目以得到该组的炎症平均得分。在子宫接种模型中，接受空载体阴性对照免疫的动物表现出一致的炎症情况，卵巢/输卵管平均炎症得分6.12，与此不同，DNA免疫组的分数是2.62。在阴道接种和上行感染模型中，阴性对照免疫的小鼠具有8.37的卵巢/输卵管平均炎症得分，相对地DNA免疫组为5.00。而且，在后一模型中，接种过的小鼠没有表现出输卵管闭塞的迹象，而阴性对照接种的组在输卵管内腔中有炎性细胞。

在第二个实验中，用包封在乳酸-羟基乙酸共聚物微球(PolyLactide co-Glycolide，PLG)中的50μg含有沙眼衣原体SWIB DNA(SEQID NO：1，相应的氨基酸序列提供在SEQ ID NO：5)的pcDNA-3表达载体3次免疫C3H小鼠(每组4只小鼠)；腹膜内方式进行免疫。最后一次免疫后2周，孕酮处理动物，并通过在阴道中接种鹦鹉热衣原体进行感染。感染后2周，处死小鼠，对生殖道进行切片、染色和组织病理学检查。按前述进行炎症水平的评分。将各个输卵管/卵巢的得分加合起来然后除以检查的器官数目以得到该组的炎症平均得分。接受PLG包封的空载体的阴性对照免疫小鼠表现出一致的炎症情况，卵巢/输卵管平均炎症得分7.28，相对地用PLG包封的DNA免疫的组为5.71。腹膜中炎症对于接受接种的组而言为1.75，而对于对照而言为3.75。

在第三个实验中，用与霍乱毒素(CT)混合的10μg纯化重组蛋白质SWIB(SEQ ID NO：1，相应的氨基酸序列提供在SEQ ID NO：5)或S13(SEQ ID NO：4，相应的氨基酸序列提供在SEQ ID NO：12)3次免疫C3H小鼠(每组4只小鼠)；麻醉后在20μl体积中通过鼻内方式施用该制剂。最后一次免疫后2周，用孕酮处理动物，并通过在阴道中接种鹦鹉热衣原体或在子宫中注射沙眼衣原体血清变型F进行感染。感染后2周，处死小鼠，对生殖道进行切片、染色和组织病理学检查。按上述对炎症程度评分。将各个输卵管/卵巢的得分加合起来然后除以检查的器官数目以得到该组的炎症平均得分。子宫接种模型中，接受单纯霍乱毒素的阴性对照免疫小鼠表现出4.25的卵巢/输卵管平均炎症得分(仅分析了2只小鼠；另2只小鼠死亡)，相对地用S13加霍乱毒素免疫的组得分5.00，用SWIB加霍乱毒素免疫的组得分1.00。未处理的感染动物具有7的卵巢/输卵管平均炎症得分。在阴道接种和上行感染模型中，阴性对照免疫小鼠表现出7.37的卵巢/输卵管平均炎症得分，相对地用S13加霍乱毒素免疫的组得分6.75，用SWIB加霍乱毒素免疫的组得分5.37。未处理的感染动物具有8的卵巢/输卵管平均炎症得分。

上述3个实验提示，可以获得SWIB特异性保护。该保护作用在同种感染模型中更为明显，但在用鹦鹉热衣原体进行的异种攻击感染中也存在此保护作用。

2.CT529/Cap1

CT529/Cap1前面被鉴定为可以刺激CD8+CTL的衣原体产物。在该实施例中，我们设法证实在衣原体感染动物模型中用Cap1进行免疫将具有保护性。

为了制备重组痘苗病毒用于递送Cap1免疫原性片断，使用PCR^TM从沙眼衣原体L2基因组DNA扩增含有修饰的Kozak序列和cap1基因(CT529)第319-530位碱基对的DNA片断，并将该片断连入pSC11ss(Ear1 PL，Koenig S，Moss B(1991)人类免疫缺陷病毒1型被膜糖蛋白的生物学和免疫学性质：通过重组痘苗病毒表达截短蛋白和具有缺失的蛋白进行的分析，J.Virol.65：31-41)。用SalI和StuI消化DNA。连接至pSC11ss中的cap1基因部分编码Cap1蛋白的第107-176位氨基酸，其中含有早先鉴定的第139-147位氨基酸的CTL表位。所获质粒用于转染CV-1细胞(ATCC#CCL-70；Jensen FC等(1964)用劳斯肉瘤病毒感染人和猿的组织培养物，Proc.Natl.Acad.Sci.USA 52：53-59)，随后用野生型痘苗病毒再感染该细胞。野生型病毒和质粒DNA的同源重组产生重组痘苗病毒，基于β-半乳糖苷酶表达和胸苷激酶的失活按早先的描述(Chakrabarti等，Mol.Cell.Biol.1985，5(12)：3403-9)选择重组病毒。噬斑纯化重组病毒3次，并在人TK-143B细胞上生长后进行滴定。用等体积的0.25mg/ml胰蛋白酶37℃处理病毒制品30分钟。然后将其稀释在PBS中，随后用于免疫小鼠。使用5只小鼠组成的组作为所有的实验和对照组。以下给出的数据是三个独立实验的代表。

用10⁶重组痘苗病毒腹膜内(i.p.)免疫一组小鼠，然后允许其恢复3周。用单纯缓冲液或野生型痘苗病毒免疫阴性对照组。作为阳性对照组，用10⁶i.f.u.沙眼衣原体静脉内(i.v.)感染小鼠组。先前已经证实了给予阳性对照组的生物数目可以在2周内被清除。3周后，用10⁶i.f.u.沙眼衣原体静脉内攻击各组的动物。攻击后3天，处死动物并确定每个脾脏的i.f.u.数。

用表达Cap1的痘苗病毒免疫的动物(7.1×10⁴)与用缓冲液(1.8×10⁵)或野生型痘苗(1.9×10⁵)免疫的对照组动物比较，脾脏中发现的生物平均数目少了2.6倍(p＜0.01；Wilcoxon氏秩和检验)。阳性组中的动物每个脾脏所含生物(2.4×10³)比阴性对照组动物低77倍(P＜0.01；Wilcoxon’s秩和检验)。这些数据表明，用Cap1的免疫原性片断进行免疫可以提供统计学显著水平的抗沙眼衣原体感染保护。

实施例10

Pmp/Ra12融合蛋白

通过首先使用含有NotI限制性位点的引物合成Pmp基因的PCR片断，制备多种Pmp/Ra12融合构建体。然后将各PCR片断连接至pCRX1的NotI限制性位点中。pCRX1载体含有该融合物的6HisRa12部分。该融合构建体的Ra12部分编码相应于结核分枝杆菌MTB32A(描述在美国专利申请60/158,585中，其公开文本并入本文作为参考)第192-323位氨基酸残基的多肽。每个插入片断的正确取向均通过其限制性酶谱确定，并对其序列进行验证。对于PmpA、PmpB、PmpC、PmpF和PmpH，制备了多个融合构建体，见如下进一步描述：

PmpA融合蛋白

PmpA是含有982个氨基酸的107kD蛋白质，克隆自血清变型E。将PmpA蛋白质分成2个重叠片断，PmpA(N-端)和(C端)部分。

PmpA(N端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCATGTTTATAACAAAGGAACTTATG(SEQ ID NO：306)GAGAGCGGCCGCTTACTTAGGTGAGAAGAAGGGAGTTTC(SEQ ID NO：307)。所获融合构建体具有SEQ ID NO：308所示DNA序列，编码表达PmpA的第1-473位氨基酸区段的66kD蛋白(619个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：309。

PmpA(C端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCCATTCTATTCATTTCTTTGATCCTG(SEQ ID NO：310)GAGAGCGGCCGCTTAGAAGCCAACATAGCCTCC(SEQ ID NO：311)。所获融合构建体具有SEQ ID NO：312所示DNA序列，其编码表达PmpA的第438-982位氨基酸区段的74kD蛋白(691个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：313.

PmpF融合蛋白

PmpF是含有1034个氨基酸的112kD蛋白质，克隆自血清变型E。将PmpF蛋白质分成2个重叠片断，PmpF(N-端)和(C端)部分。

PmpF(N端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCATGATTAAAAGAACTTCTCTATCC(SEQ ID NO：314)GAGAGCGGCCGCTTATAATTCTGCATCATCTTCTATGGC(SEQ ID NO：315)。所获融合构建体具有SEQ ID NO：316所示DNA序列，编码表达PmpF的第1-499位氨基酸区段的69kD蛋白(646个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：317.

PmpF(C端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGACATACGAACTCTGATGGG(SEQ ID NO：318)GAGAGCGGCCGCTTAAAAGACCAGAGCTCCTCC(SEQ ID NO：319)。所获融合构建体具有SEQ ID NO：320所示DNA序列，其编码表达PmpF的第466-1034位氨基酸区段的77kD蛋白(715个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：321.

PmpH融合蛋白

PmpH是含有1016个氨基酸的108kD蛋白质，克隆自血清变型E。将PmpH蛋白质分成2个重叠片断，PmpH(N-端)和(C端)部分。

PmpH(N端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCATGCCTTTTTCTTTGAGATCTAC(SEQ ID NO：322)GAGAGCGGCCGCTTACACAGATCCATTACCGGACTG(SEQ ID NO：323)。所获融合构建体具有SEQ ID NO：324所示DNA序列，编码表达PmpH的第1-484位氨基酸区段的64kD蛋白(631个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：325。供体系CHH037被发现对该蛋白质有反应性。

PmpH(C端)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGATCCTGTAGTACAAAATAATTCAGC(SEQ ID NO：326)GAGAGCGGCCGCTTAAAAGATTCTATTCAAGCC(SEQ ID NO：327)。所获融合构建体具有SEQ ID NO：328所示DNA序列，其编码表达PmpH的第449-1016位氨基酸区段的77kD蛋白(715个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：329。患者系CT12被发现具有响应该蛋白的反应性。

PmpB融合蛋白

PmpB是含有1750个氨基酸的183kD蛋白质，克隆自血清变型E。将PmpB蛋白质分成4个重叠片断，PmpB(1)，(2)，(3)和(4)。

PmpB(1)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCATGAAATGGCTGTCAGCTACTGCG(SEQ ID NO：330)GAGAGCGGCCGCTTACTTAATGCGAATTTCTTCAAG(SEQ ID NO：331)。所获融合构建体具有SEQ ID NO：332所示DNA序列，编码表达PmpB的第1-372位氨基酸区段的53kD蛋白(518个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：333。

PmpB(2)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGGTGACCTCTCAATTCAATCTTC(SEQ ID NO：334)GAGAGCGGCCGCTTAGTTCTCTGTTACAGATAAGGAGAC(SEQ ID NO：335)。所获融合构建体具有SEQ ID NO：336所示DNA序列，编码表达PmpB的第330-767位氨基酸区段的60kD蛋白(585个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：337。来源于患者系CT1、CT3、CT4的细胞系对该重组pmpB蛋白质产生应答。

PmpB(3)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGACCAACTGAATATCTCTGAGAAC(SEQ ID NO：338)GAGCGGCCGCTTAAGAGACTACGTGGAGTTCTG(SEQ ID NO：339)。所获融合构建体具有SEQ ID NO：340所示DNA序列，编码表达PmpB的第732-1236位氨基酸区段的67kD蛋白(654个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：341。

PmpB(4)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGGAACTATTGTGTTCTCTTCTG(SEQ ID NO：342)GAGAGCGGCCGCTTAGAAGATCATGCGAGCACCGC(SEQ ID NO：343)。所获融合构建体具有SEQ ID NO：344所示DNA序列，编码表达PmpB的第1160-1750位氨基酸区段的76kD蛋白(700个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：345。

PmpC融合蛋白

PmpC是含有1774个氨基酸的187kD蛋白质，克隆自血清变型E/L2。将PmpC蛋白质分成3个重叠片断，PmpC(1)，(2)和(3)。

PmpC(1)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCATGAAATTTATGTCAGCTACTGC(SEQ ID NO：346)GAGAGCGGCCGCTTACCCTGTAATTCCAGTGATGGTC(SEQ ID NO：347)。所获融合构建体具有SEQ ID NO：348所示DNA序列，编码表达PmpC的第1-340位氨基酸区段的51kD蛋白(487个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：349。

PmpC(2)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGATACACAAGTATCAGAATCACC(SEQ ID NO：350)GAGAGCGGCCGCTTAAGAGGACGATGAGACACTCTCG(SEQ ID NO：351)。所获融合构建体具有SEQ ID NO：352所示DNA序列，编码表达PmpC的第305-741位氨基酸区段的60kD蛋白(583个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：353。

PmpC(3)用如下有义和反义引物扩增：所述引物分别是GAGAGCGGCCGCTCGATCAATCTAACGAAAACACAGACG(SEQ ID NO：354)GAGAGCGGCCGCTTAGACCAAAGCTCCATCAGCAAC(SEQ ID NO：355)。所获融合构建体具有SEQ ID NO：356所示DNA序列，编码表达PmpC的第714-1250位氨基酸区段的70kD蛋白(683个氨基酸)。该融合蛋白的氨基酸序列显示在SEQ ID NO：357。

实施例11

CT622的免疫原性

从两名衣原体感染患者制备得到衣原体特异性T细胞系，这些细胞系命名为CT1和CT13。这些T细胞系或者是针对感染了沙眼衣原体血清变型E 72小时的单核细胞来源的树突细胞制备的(CT1-ERB)或是针对杀死的血清变型E原生小体(EB)制备的(CT13-EEB)。一旦制备后，在增殖试验中针对重组衣原体特异性蛋白质CT622测试这些细胞系。通过如下方式进行增殖试验：在1×10⁴个单核细胞来源的树突细胞存在时用重组CT抗原(2μg/ml)或衣原体EB(1μg/ml)刺激2.5×10⁴个T细胞。在该试验中，孵育4天，用³H-胸苷脉冲最后18小时。

当用CT622、CT875和CT EB进行刺激时，细胞系CT1-ERB表现出显著高于培养基对照的增殖应答。当用CT622、CT875和CT EB刺激时，细胞系CT13-EEB表现出显著高于培养基对照的增殖应答(见图12)。

实施例12

克隆和表达全长沙眼衣原体基因CT611、ORF3和OppA1

对含有基因CT611、ORF-3和OppA1的克隆进行全长开发阅读框的重组蛋白质表达。含有目的基因的克隆是编码4个ORF(CT474，CT473，CT060和CT139)的CtL2-8(SEQ ID NO：285)、编码CT610和CT611的ORF的CtL2-10(SEQ ID NO：284)，以及均含有与ORF-3相关的序列的克隆16CtL2-16(SEQ ID NO：47)、16-D4-22(SEQ ID NO：119)和19-A5-54(SEQ ID NO：84)。通过T细胞表达克隆方法还独立地鉴定了CtL2-10(Ct-610)和CtL2-16(ORF-3)中的序列。由于克隆CtL2-8刺激针对血清变型E制备的两个T细胞系产生增殖应答和IFN-γ生产，故对该克隆进行了进一步研究。

克隆序列的克隆和表达：

CtL2-10被发现编码2个开放阅读框(ORF)，CT610和CT611，这些ORF被发现在基因组克隆中彼此相邻排列。CT610的全长ORF(含有PQQ合成域)先前已得以表达，并且被证实可以刺激抗衣原体产生的T细胞系的增殖应答。为了确定第二个ORF(CT611)是否也能被T细胞识别，PCR扩增CT611的全长序列并对其进行工程化用于蛋白表达。其核苷酸序列公开在SEQ ID NO：361中，相应氨基酸序列公开在SEQ ID NO：365中。

第二个血清学克隆CtL2-8被发现含有4个ORF(CT474，CT473，CT060和CT139)。三个最小预测ORF(CT474、CT473和CT060)的重叠肽不刺激T细胞系的增殖应答。这提示，免疫刺激性抗原位于第4个ORF(CT139)中。CT139的ORF为大约450个核苷酸。全长核苷酸序列公开在SEQ ID NO：359中，而全长氨基酸序列公开在SEQ ID NO：363中。与GenBank的氨基酸比较揭示，其是寡肽结合蛋白(oppA1)并且其属于肽ABC转运体家族。该蛋白长462个氨基酸，具有预测的48.3kDa大小，并似乎含有2个跨膜区域。

为了表达oppA1的全长序列，设计引物特异地扩增从第22位氨基酸起始的序列(缺少第一个跨膜域)，其核苷酸序列公开在SEQ ID NO：358中，其氨基酸序列公开SEQ ID NO：362中。已经证实在大肠杆菌中该序列表达此蛋白质。

此外还获得ORF-3的全长克隆和重组蛋白质表达。核苷酸和氨基酸序列分别公开在SEQ ID NO：360和364中。

实施例13

T细胞系所识别的重组衣原体抗原

从如下供体产生患者T细胞系：CT1、CT2、CT3、CT4、CT5、CT6、CT7、CT8、CT9、CT10、CT11、CT12、CT13、CT14、CT15和CT16，其中一些见上述讨论。它们的详情总结在表V中。

表V：沙眼衣原体患者
表V：沙眼衣原体患者							患者	性别	年龄	临床表现	血清变型	IgG效价	多重感染
CT1	M	27	NGU	LCR	阴性	No	患者	性别	年龄	临床表现	血清变型	IgG效价	多重感染
CT1	M	27	NGU	LCR	阴性	No	CT2	M	24	NGU	D	阴性	E
CT3	M	43	无症状排出EbDx是HPV	J	Ct1：512Cp1：1024Cps1：256	No	CT2	M	24	NGU	D	阴性	E
CT3	M	43	无症状排出EbDx是HPV	J	Ct1：512Cp1：1024Cps1：256	No	CT4	F	25	无症状排出Eb	J	Ct1：1024	Y
CT5	F	27	BV	LCR	Ct1：256Cp1：256	F/F	CT4	F	25	无症状排出Eb	J	Ct1：1024	Y
CT5	F	27	BV	LCR	Ct1：256Cp1：256	F/F	CT6	M	26	会阴疹流出物，排尿困难	G	Cp1：1024	N
CT7	F	29	BV生殖器溃疡	E	Ct1：512Cp1：1024	N	CT6	M	26	会阴疹流出物，排尿困难	G	Cp1：1024	N
CT7	F	29	BV生殖器溃疡	E	Ct1：512Cp1：1024	N	CT8	F	24	未知	LCR	未测	NA
CT9	M	24	无症状	LCR	Ct1：128Cp1：128	N	CT8	F	24	未知	LCR	未测	NA
CT9	M	24	无症状	LCR	Ct1：128Cp1：128	N	CT10	F	20	中度外阴搔痒	阴性	阴性	12/1/98

CT11	F	21	BV帕普涂片异常	J	Ct1：512	F/F/J/E/EPID6/96
CT11	F	21	BV帕普涂片异常	J	Ct1：512	F/F/J/E/EPID6/96	CT12	M	20	无症状	LCR	Cp1：512	N
CT13	F	18	BV，淋病，Ct阴道流出物，排尿困难	G	Ct1：1024	N	CT12	M	20	无症状	LCR	Cp1：512	N
CT13	F	18	BV，淋病，Ct阴道流出物，排尿困难	G	Ct1：1024	N	CT14	M	24	NGU	LCR	Ct1：256Cp1：256	N
CT15	F	21	粘液脓性宫颈炎阴道流出物	培养物	Ct1：256CtIgM1：320Cp1：64	N	CT14	M	24	NGU	LCR	Ct1：256Cp1：256	N
CT15	F	21	粘液脓性宫颈炎阴道流出物	培养物	Ct1：256CtIgM1：320Cp1：64	N	CT16	M	26	无症状/有过接触	LCR	NA	N
CL8	M	38	无临床疾病史	阴性	阴性	N	CT16	M	26	无症状/有过接触	LCR	NA	N

NGU＝非淋球菌性尿道炎；BV＝细菌性阴道病；CT＝沙眼衣原体；Cp＝肺炎衣原体；Eb＝衣原体原生小体；HPV＝人乳头瘤病毒；Dx＝诊断；PID＝盆腔炎；LCR＝连接酶链式反应。

收集一系列供体的PBMC，并从其中的亚群制备T细胞系。下表中总结了3个这种T细胞系的详细情况。

表III：正常供体
表III：正常供体					供体	性别	年龄	CTIgG效价	CPIgG效价
CHH011	F	49	1：64	1：16	供体	性别	年龄	CTIgG效价	CPIgG效价
CHH011	F	49	1：64	1：16	CHH037	F	22	0	0
CHH042	F	25	0	1：16	CHH037	F	22	0	0

供体CHH011是沙眼衣原体血清阴性的49岁健康女性供体。PBMC应答沙眼衣原体原生小体比应答肺炎衣原体原生小体产生更大量的IFN-γ，表明是沙眼衣原体特异性应答。供体CHH037是沙眼衣原体血清阴性的22岁健康女性供体。PBMC应答沙眼衣原体原生小体比应答肺炎衣原体原生小体产生更大量的IFN-γ，说明此是沙眼衣原体特异性应答。CHH042是对肺炎衣原体具有1：16的IgG效价的25岁健康女性供体。PBMC应答沙眼衣原体原生小体比应答肺炎衣原体原生小体产生更大量的IFN-γ，说明此是沙眼衣原体特异性应答。

按上述制备几个沙眼衣原体基因的重组蛋白。MOMP的序列来源于血清变型F。基因CT875、CT622、pmp-B-2、pmpA和CT529来源于血清变型E，而gro-EL、Swib、pmpD、pmpG、TSA、CT610、pmpC、pmpE、S13、lpdA、pmpI和pmpH-C基因的序列来源于LII。

针对这些重组衣原体蛋白质，测试上述几个患者和供体系。表IV总结了T细胞对这些重组衣原体蛋白质的应答结果。

表VII：T细胞系识别的重组衣原体抗原
表VII：T细胞系识别的重组衣原体抗原														抗原	血清变型	命中数	CL8L2	CT10E	CT1E	CT3E	CT4L2	CT5E	CT11E	CT12E	CT13E	CHH-011E	CHH-037E
gro-EL(CT110)	L2	10	-	+	+	+	+	+	+	+	+	+	+	抗原	血清变型	命中数	CL8L2	CT10E	CT1E	CT3E	CT4L2	CT5E	CT11E	CT12E	CT13E	CHH-011E	CHH-037E
gro-EL(CT110)	L2	10	-	+	+	+	+	+	+	+	+	+	+	MompF(CT681)	F	10	-	+	+	+	+	+	+	+	+	+	+
CT875	E	8	-	+	+	-	+	+	+	+	+	-	+	MompF(CT681)	F	10	-	+	+	+	+	+	+	+	+	+	+
CT875	E	8	-	+	+	-	+	+	+	+	+	-	+	SWIB(CT460)	L2	8	+	+	-	+	-	+	-	+	+	+	+
pmpD(CT812)	L2	5	-	+	+	+	+	-	-	+	+	-	-	SWIB(CT460)	L2	8	+	+	-	+	-	+	-	+	+	+	+

pmpG(CT871)	L2	6	-	+	+	-	+	+	nt	-	+	+	-
pmpG(CT871)	L2	6	-	+	+	-	+	+	nt	-	+	+	-	TSA(CT603)	L2	6	-	-	+	+	+	+	-	-	+	-	+
CT622	E	3	-	-	+	-	+	-	-	-	+	-	-	TSA(CT603)	L2	6	-	-	+	+	+	+	-	-	+	-	+
CT622	E	3	-	-	+	-	+	-	-	-	+	-	-	CT610	L2	3	-	+	-	+	-	-	-	+	-	-	-
pmpB-2(CT413)	E	3	-	-	+	+	+	-	-	-	-	-	-	CT610	L2	3	-	+	-	+	-	-	-	+	-	-	-
pmpB-2(CT413)	E	3	-	-	+	+	+	-	-	-	-	-	-	pmpC(CT414)	L2	4	-	-	-	+	-	+	-	+	-	-	+
pmpE(CT869)	L2	3	-	+	+	-	-	-	-	-	+	-	-	pmpC(CT414)	L2	4	-	-	-	+	-	+	-	+	-	-	+
pmpE(CT869)	L2	3	-	+	+	-	-	-	-	-	+	-	-	S13(CT509)	L2	2	+	-	-	-	+	-	-	-	-	-	-
lpdA(CT557)	L2	3	-	-	+	+	-	-	-	-	-	+	-	S13(CT509)	L2	2	+	-	-	-	+	-	-	-	-	-	-
lpdA(CT557)	L2	3	-	-	+	+	-	-	-	-	-	+	-	pmpl(CT874)	L2	2	-	-	+	-	-	-	-	-	-	+	-
pmpH-C(CT872)	L2	1	-	-	-	-	-	-	-	+	-	-	-	pmpl(CT874)	L2	2	-	-	+	-	-	-	-	-	-	+	-
pmpH-C(CT872)	L2	1	-	-	-	-	-	-	-	+	-	-	-	pmpA(CT412)	E	0	-	-	-	-	-	-	-	-	-	-	-
CT529	E	0	-	-	-	-	-	-	-	-	-	-	-	pmpA(CT412)	E	0	-	-	-	-	-	-	-	-	-	-	-

尽管为了清楚理解的目的本发明通过举例说明和实施例的方式进行了相当详细的描述，但可以进行修改和改变而不偏离本发明的范围，本发明的范围旨在仅受所附权利要求范围的限制。序列表

序列表

<110>Corixa Corporation

Fling，Steven P.

Skeiky，Yasir A.W.

Probst，Peter

Bhatia，Ajay

<120>用于治疗和诊断衣原体感染的化合物和方法

<130>210121.46902PC

<140>PCT

<141>2001-07-20

<160>599

<170>FastSEQ for Windows Version 3.0/4.0

<210>1

<211>481

<212>DNA

<213>沙眼衣原体(Chlamydia trachomatis)

<400>1ctgaagactt ggctatgttt tttattttga cgataaacct agttaaggca taaaagagtt 60gcgaaggaag agccctcaac ttttcttatc accttcttta actaggagtc atccatgagt 120caaaataaga actctgcttt catgcagcct gtgaacgtat ccgctgattt agctgccatc 180gttggtgcag gacctatgcc tcgcacagag atcattaaga aaatgtggga ttacattaag 240gagaatagtc ttcaagatcc tacaaacaaa cgtaatatca atcccgatga taaattggct 300aaagtttttg gaactgaaaa acctatcgat atgttccaaa tgacaaaaat ggtttctcaa 360cacatcatta aataaaatag aaattgactc acgtgttcct cgtctttaag atgaggaact 420agttcattct ttttgttcgt ttttgtgggt attactgtat ctttaacaac tatcttagca 480g 481

<210>2

<211>183

<212>DNA

<213>沙眼衣原体

<400>2atcgttggtg caggacctat gcctcgcaca gagatcatta agaaaatgtg ggattacatt 60aaggagaata gtcttcaaga tcctacaaac aaacgtaata tcaatcccga tgataaattg 120gctaaagttt ttggaactga aaaacctatc gatatgttcc aaatgacaaa aatggtttct 180caa 183

<210>3

<211>110

<212>DNA

<213>沙眼衣原体

<400>3gctgcgacat catgcgagct tgcaaaccaa catggacatc tccaatttcc ccttctaact 60cgctctttgg aactaatgct gctaccgagt caatcacaat cacatcgacc 110

<210>4

<211>555

<212>DNA

<213>沙眼衣原体

<400>4cggcacgagc ctaagatgct tatactactt taagggaggc ccttcgtatg ccgcgcatca 60ttggaataga tattcctgcg aaaaagaaat taaaaataag tcttacatat atttatggaa 120tagggccagc tctttctaaa gagattattg ctagattgca gttgaatccc gaagctagag 180ctgcagagtt gactgaggaa gaggttggtc gactaaacgc tcttttacag tcggattacg 240ttgttgaagg ggatttgcgc cgtcgtgtgc aatctgatat caaacgtctg attactatcc 300atgcttatcg tggacaaaga catagacttt ctttgcctgt tcgtggtcag agaacaaaaa 360caaattctcg cacgcgtaag ggtaaacgta aaactattgc aggtaagaag aaataataat 420ttttaggaga gagtgttttg gttaaaaatc aagcgcaaaa aagaggcgta aaaagaaaac 480aagtaaaaaa cattccttcg ggcgttgtcc atgttaaggc tacttttaat aatacaattg 540taaccataac agacc 555

<210>5

<211>86

<212>PRT

<213>沙眼衣原体

<400>5Met Ser Gln Asn Lys Asn Ser Ala Phe Met Gln Pro Val Asn Val Ser1 5 10 15Ala Asp Leu Ala Ala Ile Val Gly Ala Gly Pro Met Pro Arg Thr Glu

20 25 30Ile Ile Lys Lys Met Trp Asp Tyr Ile Lys Glu Asn Ser Leu Gln Asp

35 40 45Pro Thr Asn Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys Val

50 55 60Phe Gly Thr Glu Lys Pro Ile Asp Met Phe Gln Met Thr Lys Met Val65 70 75 80Ser Gln His Ile Ile Lys

85

<210>6

<211>61

<212>PRT

<213>沙眼衣原体

<400>6Ile Val Gly Ala Gly Pro Met Pro Arg Thr Glu Ile Ile Lys Lys Met1 5 10 15Trp Asp Tyr Ile Lys Glu Asn Ser Leu Gln Asp Pro Thr Asn Lys Arg

20 25 30Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys Val Phe Gly Thr Glu Lys

35 40 45Pro Ile Asp Met Phe Gln Met Thr Lys Met Val Ser Gln

50 55 60

<210>7

<211>36

<212>PRT

<213>沙眼衣原体

<400>7Ala Ala Thr Ser Cys Glu Leu Ala Asn Gln His Gly His Leu Gln Phe1 5 10 15Pro Leu Leu Thr Arg Ser Leu Glu Leu Met Leu Leu Pro Ser Gln Ser

20 25 30Gln Ser His Arg

35

<210>8

<211>18

<212>PRT

<213>沙眼衣原体

<400>8Leu Arg His His Ala Ser Leu Gln Thr Asn Met Asp Ile Ser Asn Phe1 5 10 15Pro Phe

<210>9

<211>5

<212>PRT

<213>沙眼衣原体

<400>9Leu Ala Leu Trp Asn1 5

<210>10

<211>11

<212>PRT

<213>沙眼衣原体

<400>10Cys Cys Tyr Arg Val Asn His Asn His Ile Asp1 5 10

<210>11

<211>36

<212>PRT

<213>沙眼衣原体

<400>11Val Asp Val Ile Val Ile Asp Ser Val Ala Ala Leu Val Pro Lys Ser1 5 10 15Glu Leu Glu Gly Glu Ile Gly Asp Val His Val Gly Leu Gln Ala Arg

20 25 30Met Met Ser Gln

35

<210>12

<211>122

<212>PRT

<213>沙眼衣原体

<400>12Met Pro Arg Ile Ile Gly Ile Asp Ile Pro Ala Lys Lys Lys Leu Lys1 5 10 15Ile Ser Leu Thr Tyr Ile Tyr Gly Ile Gly Pro Ala Leu Ser Lys Glu

20 25 30Ile Ile Ala Arg Leu Gln Leu Asn Pro Glu Ala Arg Ala Ala Glu Leu

35 40 45Thr Glu Glu Glu Val Gly Arg Leu Asn Ala Leu Leu Gln Ser Asp Tyr

50 55 60Val Val Glu Gly Asp Leu Arg Arg Arg Val Gln Ser Asp Ile Lys Arg65 70 75 80Leu Ile Thr Ile His Ala Tyr Arg Gly Gln Arg His Arg Leu Ser Leu

85 90 95Pro Val Arg Gly Gln Arg Thr Lys Thr Asn Ser Arg Thr Arg Lys Gly

100 105 110Lys Arg Lys Thr Ile Ala Gly Lys Lys Lys

115 120

<210>13

<211>20

<212>PRT

<213>沙眼衣原体

<400>13Asp Pro Thr Asn Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys1 5 10 15Val Phe Gly Thr

20

<210>14

<211>20

<212>PRT

<213>沙眼衣原体

<400>14Asp Asp Lys Leu Ala Lys Val Phe Gly Thr Glu Lys Pro Ile Asp Met1 5 10 15Phe Gln Met Thr

20

<210>15

<211>161

<212>DNA

<213>沙眼衣原体

<400>15atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcttc atcggaggaa 60ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac aaaatgctgg 120cgcaaccgtt tctttcttcc caaactaaag caaatatggg a 161

<210>16

<211>897

<212>DNA

<213>沙眼衣原体

<400>16atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>17

<211>298

<212>PRT

<213>沙眼衣原体

<400>17Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

50 55 60Ala His Ile Thr Ala Ser Gln Val Ser Lys Gly Leu Gly Asp Ala Arg65 70 75 80Thr Val Val Ala Leu Gly Asn Ala Phe Asn Gly Ala Leu Pro Gly Thr

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

130 135 140Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160Lys Met Leu Ala Lys Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Pro Gly

210 215 220Glu Glu Asn Ala Cys Glu Lys Lys Val Ala Gly Glu Lys Ala Lys Thr225 230 235 240Phe Thr Arg Ile Lys Tyr Ala Leu Leu Thr Met Leu Glu Lys Phe Leu

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>18

<211>18

<212>PRT

<213>沙眼衣原体

<400>18Arg Ala Ala Ala Ala Ala Ala Val Cys Ser Phe Ile Gly Gly Ile Thr1 5 10 15Tyr Leu

<210>19

<211>18

<212>PRT

<213>沙眼衣原体

<400>19Cys Ser Phe Ile Gly Gly Ile Thr Tyr Leu Ala Thr Phe Gly Ala Ile 1 5 10 15Arg Pro

<210>20

<211>216

<212>PRT

<213>沙眼衣原体

<400>20Met Arg Gly Ser Gln Gln Ile Phe Val Cys Leu Ile Ser Ala Glu Arg1 5 10 15Leu Arg Leu Ser Val Ala Ser Ser Glu Glu Leu Pro Thr Ser Arg His

20 25 30Ser Glu Leu Ser Val Arg Phe Cys Leu Ser Thr Lys Cys Trp Gln Asn

35 40 45Arg Phe Phe Leu Pro Lys Leu Lys Gln Ile Trp Asp Leu Leu Leu Ala

50 55 60Ile Leu Trp Arg Leu Thr Met Gln Arg Leu Trp Trp Val Leu Asp Ser65 70 75 80Leu Ser Val Arg Lys Glu Gln Ile Ala Lys Pro Ala Ala Leu Val Leu

85 90 95Arg Glu Lys Ser Arg Tyr Ser Lys Cys Arg Glu Arg Lys Met Leu Ala

l00 105 110Arg Arg Lys Ser Leu Glu Arg Lys Pro Arg Arg Ser Arg Ala Ser Ser

115 120 125Met His Ser Ser Leu Cys Ser Arg Ser Phe Trp Asn Ala Leu Pro Thr

130 135 140Phe Ser Asn Trp Cys Arg Cys Leu Leu Gln Trp Val Phe Val Arg Leu145 150 155 160Trp Leu Leu Asp Val Arg Ser Leu Leu Gln Leu Leu Asp Cys Ala Leu

165 170 175Ser Ala Pro Glu His Lys Gly Phe Phe Lys Phe Leu Lys Lys Lys Ala

180 185 190Val Ser Lys Lys Lys Gln Pro Phe Leu Ser Thr Lys Cys Leu Ala Phe

195 200 205Leu Ile Val Lys Ile Val Phe Leu

210 215

<210>21

<211>1256

<212>DNA

<213>沙眼衣原体

<400>21ctcgtgccgg cacgagcaaa gaaatccctc aaaaaatggc cattattggc ggtggtgtga 60tcggttgcga attcgcttcc ttattccata cgttaggctc cgaagtttct gtgatcgaag 120caagctctca aatccttgct ttgaataatc cagatatttc aaaaaccatg ttcgataaat 180tcacccgaca aggactccgt ttcgtactag aagcctctgt atcaaatatt gaggatatag 240gagatcgcgt tcggttaact atcaatggga atgtcgaaga atacgattac gttctcgtat 300ctataggacg ccgtttgaat acagaaaata ttggcttgga taaagctggt gttatttgtg 360atgaacgcgg agtcatccct accgatgcca caatgcgcac aaacgtacct aacatttatg 420ctattggaga tatcacagga aaatggcaac ttgcccatgt agcttctcat caaggaatca 480ttgcagcacg gaatataggt ggccataaag aggaaatcga ttactctgct gtcccttctg 540tgatctttac cttccctgaa gtcgcttcag taggcctctc cccaacagca gctcaacaac 600atctccttct tcgcttactt tttctgaaaa atttgataca gaagaagaat tcctcgcaca 660cttgcgagga ggagggcgtc tggaagacca gttgaattta gctaagtttt ctgagcgttt 720tgattctttg cgagaattat ccgctaagct tggttacgat agcgatggag agactgggga 780tttcttcaac gaggagtacg acgacgaaga agaggaaatc aaaccgaaga aaactacgaa 840acgtggacgt aagaagagcc gttcataagc cttgctttta aggtttggta gttttacttc 900tctaaaatcc aaatggttgc tgtgccaaaa agtagtttgc gtttccggat agggcgtaaa 960tgcgctgcat gaaagattgc ttcgagagcg gcatcgcgtg ggagatcccg gatactttct 1020ttcagatacg aataagcata gctgttccca gaataaaaac ggccgacgct aggaacaaca 1080agatttagat agagcttgtg tagcaggtaa actgggttat atgttgctgg gcgtgttagt 1140tctagaatac ccaagtgtcc tccaggttgt aatactcgat acacttccct aagagcctct 1200aatggatagg ataagttccg taatccatag gccatagaag ctaaacgaaa cgtatt 1256

<210>22

<211>601

<212>DNA

<213>沙眼衣原体

<400>22ctcgtgccgg cacgagcaaa gaaatccctc aaaaaatggc cattattggc ggtggtgtga 60tcggttgcga attcgcttcc ttattccata cgttaggctc cgaagtttct gtgatcgaag 120caagctctca aatccttgct ttgaataatc cagatatttc aaaaaccatg ttcgataaat 180tcacccgaca aggactccgt ttcgtactag aagcctctgt atcaaatatt gaggatatag 240gagatcgcgt tcggttaact atcaatggga atgtcgaaga atacgattac gttctcgtat 300ctataggacg ccgtttgaat acagaaaata ttggcttgga taaagctggt gttatttgtg 360atgaacgcgg agtcatccct accgatgcca caatgcgcac aaacgtacct aacatttatg 420ctattggaga tatcacagga aaatggcaac ttgcccatgt agcttctcat caaggaatca 480ttgcagcacg gaatataggt ggccataaag aggaaatcga ttactctgct gtcccttctg 540tgatctttac cttccctgaa gtcgcttcag taggcctctc cccaacagca gctcaacaac 600a 60l

<210>23

<211>270

<212>DNA

<213>沙眼衣原体

<400>23acatctcctt cttcgcttac tttttctgaa aaatttgata cagaagaaga attcctcgca 60cacttgcgag gaggagggcg tctggaagac cagttgaatt tagctaagtt ttctgagcgt 120tttgattctt tgcgagaatt atccgctaag cttggttacg atagcgatgg agagactggg 180gatttcttca acgaggagta cgacgacgaa gaagaggaaa tcaaaccgaa gaaaactacg 240aaacgtggac gtaagaagag ccgttcataa 270

<210>24

<211>363

<212>DNA

<213>沙眼衣原体

<400>24ttacttctct aaaatccaaa tggttgctgt gccaaaaagt agtttgcgtt tccggatagg 60gcgtaaatgc gctgcatgaa agattgcttc gagagcggca tcgcgtggga gatcccggat 120actttctttc agatacgaat aagcatagct gttcccagaa taaaaacggc cgacgctagg 180aacaacaaga tttagataga gcttgtgtag caggtaaact gggttatatg ttgctgggcg 240tgttagttct agaataccca agtgtcctcc aggttgtaat actcgataca cttccctaag 300agcctctaat ggataggata agttccgtaa tccataggcc atagaagcta aacgaaacgt 360att 363

<210>25

<211>696

<212>DNA

<213>沙眼衣原体

<400>25gctcgtgccg gcacgagcaa agaaatccct caaaaaatgg ccattattgg cggtggtgtg 60atcggttgcg aattcgcttc cttattccat acgttaggct ccgaagtttc tgtgatcgaa 120gcaagctctc aaatccttgc tttgaataat ccagatattt caaaaaccat gttcgataaa 180ttcacccgac aaggactccg tttcgtacta gaagcctctg tatcaaatat tgaggatata 240ggagatcgcg ttcggttaac tatcaatggg aatgtcgaag aatacgatta cgttctcgta 300tctataggac gccgtttgaa tacagaaaat attggcttgg ataaagctgg tgttatttgt 360gatgaacgcg gagtcatccc taccgatgcc acaatgcgca caaacgtacc taacatttat 420gctattggag atatcacagg aaaatggcaa cttgcccatg tagcttctca tcaaggaatc 480attgcagcac ggaatatagg tggccataaa gaggaaatcg attactctgc tgtcccttct 540gtgatcttta ccttccctga agtcgcttca gtaggcctct ccccaacagc agctcaacaa 600catctccttc ttcgcttact ttttctgaaa aatttgatac agaagaagaa ttcctcgcac 660acttgcgagg aggagggcgt ctggaagacc agttga 696

<210>26

<211>231

<212>PRT

<213>沙眼衣原体

<400>26Ala Arg Ala Gly Thr Ser Lys Glu Ile Pro Gln Lys Met Ala Ile Ile1 5 10 15Gly Gly Gly Val Ile Gly Cys Glu Phe Ala Ser Leu Phe His Thr Leu

20 25 30Gly Ser Glu Val Ser Val Ile Glu Ala Ser Ser Gln Ile Leu Ala Leu

35 40 45Asn Asn Pro Asp Ile Ser Lys Thr Met Phe Asp Lys Phe Thr Arg Gln

50 55 60Gly Leu Arg Phe Val Leu Glu Ala Ser Val Ser Asn Ile Glu Asp Ile65 70 75 80Gly Asp Arg Val Arg Leu Thr Ile Asn Gly Asn Val Glu Glu Tyr Asp

85 90 95Tyr Val Leu Val Ser Ile Gly Arg Arg Leu Asn Thr Glu Asn Ile Gly

100 105 110Leu Asp Lys Ala Gly Val Ile Cys Asp Glu Arg Gly Val Ile Pro Thr

115 120 125Asp Ala Thr Met Arg Thr Asn Val Pro Asn Ile Tyr Ala Ile Gly Asp

130 135 140Ile Thr Gly Lys Trp Gln Leu Ala His Val Ala Ser His Gln Gly Ile145 150 155 160Ile Ala Ala Arg Asn Ile Gly Gly His Lys Glu Glu Ile Asp Tyr Ser

165 170 175Ala Val Pro Ser Val Ile Phe Thr Phe Pro Glu Val Ala Ser Val Gly

180 185 190Leu Ser Pro Thr Ala Ala Gln Gln His Leu Leu Leu Arg Leu Leu Phe

195 200 205Leu Lys Asn Leu Ile Gln Lys Lys Asn Ser Ser His Thr Cys Glu Glu

210 215 220Glu Gly Val Trp Lys Thr Ser225 230

<210>27

<211>264

<212>DNA

<213>肺炎衣原体<Chlamydia pneumoniae)

<400>27atgagtcaaa aaaataaaaa ctctgctttt atgcatcccg tgaatatttc cacagattta 60gcagttatag ttggcaaggg acctatgccc agaaccgaaa ttgtaaagaa agtttgggaa 120tacattaaaa aacacaactg tcaggatcaa aaaaataaac gtaatatcct tcccgatgcg 180aatcttgcca aagtctttgg ctctagtgat cctatcgaca tgttccaaat gaccaaagcc 240ctttccaaac atattgtaaa ataa 264

<210>28

<211>87

<212>PRT

<213>肺炎衣原体

<400>28Met Ser Gln LVs Asn Lys Asn Ser Ala Phe Met His Pro Val Asn Ile1 5 10 15Ser Thr Asp Leu Ala Val Ile Val Gly Lys Gly Pro Met Pro Arg Thr

20 25 30Glu Ile Val Lys Lys Val Trp Glu Tyr Ile Lys Lys His Asn Cys Gln

35 40 45Asp Gln Lys Asn Lys Arg Asn Ile Leu Pro Asp Ala Asn Leu Ala Lys

50 55 60Val Phe Gly Ser Ser Asp Pro Ile Asp Met Phe Gln Met Thr Lys Ala65 70 75 80Leu Ser Lys His Ile Val Lys

85

<210>29

<211>369

<212>DNA

<213>肺炎衣原体

<400>29atgccacgca tcattggaat tgatattcct gcaaagaaaa agttaaaaat aagtctgaca 60tatatttatg gaataggatc agctcgttct gatgaaatca ttaaaaagtt gaagttagat 120cctgaggcaa gagcctctga attaactgaa gaagaagtag gacgactgaa ctctctgcta 180caatcagaat ataccgtaga aggggatttg cgacgtcgtg ttcaatcgga tatcaaaaga 240ttgatcgcca tccattctta tcgaggtcag agacatagactttctttacc agtaagagga 300caacgtacaa aaactaattc tcgtactcga aaaggtaaaa gaaaaacagt cgcaggtaag 360aagaaataa 369

<210>30

<211>122

<212>PRT

<213>肺炎衣原体

<400>30Met Pro Arg Ile Ile Gly Ile Asp Ile Pro Ala Lys Lys Lys Leu Lys1 5 10 15Ile Ser Leu Thr Tyr Ile Tyr Gly Ile Gly Ser Ala Arg Ser Asp Glu

20 25 30Ile Ile Lys Lys Leu Lys Leu Asp Pro Glu Ala Arg Ala Ser Glu Leu

35 40 45Thr Glu Glu Glu Val Gly Arg Leu Asn Ser Leu Leu Gln Ser Glu Tyr

50 55 60Thr Val Glu Gly Asp Leu Arg Arg Arg Val Gln Ser Asp Ile Lys Arg65 70 75 80Leu Ile Ala Ile His Ser Tyr Arg Gly Gln Arg His Arg Leu Ser Leu

85 90 95Pro Val Arg Gly Gln Arg Thr Lys Thr Asn Ser Arg Thr Arg Lys Gly

100 105 110Lys Arg Lys Thr Val Ala Gly Lys Lys Lys

115 120

<210>31

<211>10

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>31Cys Ser Phe Ile Gly Gly Ile Thr Tyr Leu1 5 10

<210>32

<211>53

<212>PRT

<213>沙眼衣原体

<400>32Leu Cys Val Ser His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Phe1 5 10 15Ile Gly Gly Ile Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile

20 25 30Leu Phe Val Asn Lys Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Thr

35 40 45Lys Ala Asn Met Gly

50

<210>33

<211>161

<212>DNA

<213>沙眼衣原体

<400>33atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc atcggaggaa 60ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac aaaatgctgg 120caaaaccgtt tctttcttcc caaactaaag caaatatggg a 161

<210>34

<211>53

<212>PRT

<213>沙眼衣原体

<400>34Leu Cys Val Ser His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile1 5 10 15Ile Gly Gly Ile Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile

20 25 30Leu Phe Val Asn Lys Met Leu Ala Lys Pro Phe Leu Ser Ser Gln Thr

35 40 45Lys Ala Asn Met Gly

50

<210>35

<211>55

<212>DNA

<213>肺炎衣原体

<400>35gatatacata tgcatcacca tcaccatcac atgagtcaaa aaaaataaaa ctct 55

<210>36

<211>33

<212>DNA

<213>肺炎衣原体

<400>36ctcgaggaat tcttatttta caatatgttt gga 33

<210>37

<211>53

<212>DNA

<213>肺炎衣原体

<400>37gatatacata tgcatcacca tcaccatcac atgccacgca tcattggaat gat 53

<210>38

<211>30

<212>DNA

<213>肺炎衣原体

<400>38ctcgaggaat tcttatttct tcttacctgc 30

<210>39

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>39Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys Val Phe Gly Thr1 5 10 15

<210>40

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>40Lys Arg Asn Ile Leu Pro Asp Ala Asn Leu Ala Lys Val Phe Gly Ser1 5 10 15

<210>41

<211>15

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>41Lys Glu Tyr Ile Asn Gly Asp Lys Tyr Phe Gln Gln Ile Phe Asp1 5 10 15

<210>42

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>42Lys Lys Ile Ile Ile Pro Asp Ser Lys Leu Gln Gly Val Ile Gly Ala 1 5 10 15

<210>43

<211>15

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>43Lys Lys Leu Leu Val Pro Asp Asn Asn Leu Ala Thr Ile Ile Gly1 5 10 15

<210>44

<211>509

<212>DNA

<213>衣原体属(Chlamydia)

<400>44ggagctcgaa ttcggcacga gagtgcctat tgttttgcag gctttgtctg atgatagcga 60taccgtacgt gagattgctg tacaagtagc tgttatgtat ggttctagtt gcttactgcg 120cgccgtgggc gatttagcga aaaatgattc ttctattcaa gtacgcatca ctgcttatcg 180tgctgcagcc gtgttggaga tacaagatct tgtgcctcat ttacgagttg tagtccaaaa 240tacacaatta gatggaacgg aaagaagaga agcttggaga tctttatgtg ttcttactcg 300gcctcatagt ggtgtattaa ctggcataga tcaagcttta atgacctgtg agatgttaaa 360ggaatatcct gaaaagtgta cggaagaaca gattcgtaca ttattggctg cagatcatcc 420agaagtgcag gtagctactt tacagatcat tctgagagga ggtagagtat tccggtcatc 480ttctataatg gaatcggttc tcgtgccgg 509

<210>45

<211>481

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>23

<223>n＝A，T，C或G

<400>45gatccgaatt cggcacgagg cantatttac tcccaacatt acggttccaa ataagcgata 60aggtcttcta ataaggaagt taatgtaaga ggctttttta ttgcttttcg taaggtagta 120ttgcaaccgc acgcgattga atgatacgca agccatttcc atcatggaaa agaacccttg 180gacaaaaata caaaggaggt tcactcctaa ccagaaaaag ggagagttag tttccatggg 240ttttccttat atacacccgt ttcacacaat taggagccgc gtctagtatt tggaatacaa 300attgtcccca agcgaatttt gttcctgttt cagggatttc tcctaattgt tctgtcagcc 360atccgcctat ggtaacgcaa ttagctgtag taggaagatc aactccaaac aggtcataga 420aatcagaaag ctcataggtg cctgcagcaa taacaacatt cttgtctgag tgagcgaatt 480g 481

<210>46

<211>427

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>20

<223>n＝A，T，C或G

<400>46gatccgaatt cggcacgagn tttttcctgt tttttcttag tttttagtgt tcccggagca 60ataacacaga tcaaagaacg gccattcagt ttaggctctg actcaacaaa acctatgtcc 120tctaagccct gacacattct ttgaacaacc ttatgcccgt gttcgggata agccaactct 180cgcccccgaa acatacaaga aacctttact ttatttcctt tctcaataaa ggctctagct 240tgctttgctt tcgtaagaaa gtcgttatca tcgatattag gcttaagctt aacctctttg 300atacgcactt ggtgctgtgc tttcttacta tctttttctt ttttagttat gtcgtaacga 360tacttcccgt agtccatgat tttgcacaca ggaggctctg agtttgaagc aacctcgtgc 420cgaattc 427

<210>47

<211>600

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>522

<223>n＝A，T，C或G

<400>47gatccgaatt cggcacgaga tgcttctatt acaattggtt tggatgcgga aaaagcttac 60cagcttattc tagaaaagtt gggagatcaa attcttggtg gaattgctga tactattgtt 120gatagtacag tccaagatat tttagacaaa atcacaacag acccttctct aggtttgttg 180aaagctttta acaactttcc aatcactaat aaaattcaat gcaacgggtt attcactccc 240aggaacattg aaactttatt aggaggaact gaaataggaa aattcacagt cacacccaaa 300agctctggga gcatgttctt agtctcagca gatattattg catcaagaat ggaaggcggc 360gttgttctag ctttggtacg agaaggtgat tctaagccct acgcgattag ttatggatac 420tcatcaggcg ttcctaattt atgtagtcta agaaccagaa ttattaatac aggattgact 480ccgacaacgt attcattacg tgtaggcggt ttagaaagcg gngtggtatg ggttaatgcc 540ctttctaatg gcaatgatat tttaggaata acaaatcttc taatgtatct tttttggagg 600

<210>48

<211>600

<212>DNA

<213>衣原体属

<400>48ggagctcgaa ttcggcacga gctctatgaa tatccaattc tctaaactgt tcggataaaa 60atgatgcagg aattaggtcc acactatctt tttttgtttc gcaaatgatt gattttaaat 120cgtttgatgt gtatactatg tcgtgtaagc ctttttggtt acttctgaca ctagccccca 180atccagaaga taaattggat tgcgggtcta ggtcagcaag taacactttt ttccctaaaa 240attgggccaa gttgcatccc acgtttagag aaagtgttgt ttttccagtt cctcccttaa 300aagagcaaaa aactaaggtg tgcaaatcaa ctccaacgtt agagtaagtt atctattcag 360ccttggaaaa catgtctttt ctagacaaga aagcataat caaagccttt tttagcttta 420aactgttatc ctctaatttt tcaagaacag gagagtctgg gaataatcct aaagagtttt 480ctatttgttg aagcagtcct agaattagtg agacactttt atggtagagt tctaagggag 540aatttaagaa agttactttt tccttgttta ctcgtatttt taggtctaat tcggggaaat 600

<210>49

<211>600

<212>DNA

<213>衣原体属

<400>49gatccgaatt cggcacgaga tgcttctatt acaattggtt tggatgcgga aaaagcttac 60cagcttattc tagaaaagtt gggagatcaa attcttggtg gaattgctga tactattgtt 120gatagtacag tccaagatat tttagacaaa atcacaacag acccttctct aggtttgttg 180aaagctttta acaactttcc aatcactaat aaaattcaat gcaacgggtt attcactccc 240aggaacattg aaactttatt aggaggaact gaaataggaa aattcacagt cacacccaaa 300agctctggga gcatgttctt agtctcagca gatattattg catcaagaat ggaaggcggc 360gttgttctag ctttggtacg agaaggtgat tctaagccct acgcgattag ttatggatac 420tcatcaggcg ttcctaattt atgtagtcta agaaccagaa ttattaatac aggattgact 480ccgacaacgt attcattacg tgtaggcggt ttagaaagcg gtgtggtatg ggttaatgcc 540ctttctaatg gcaatgatat tttaggaata acaaatactt ctaatgtatc ttttttggag 600

<210>50

<211>406

<212>DNA

<213>衣原体属

<400>50gatccgaatt cggcacgagt tcttagcttg cttaattacg taattaacca aactaaaggg 60gctatcaaat agcttattca gtctttcatt agttaaacga tcttttctag ccatgactca 120tcctatgttc ttcagctata aaaatacttc ttaaaacttg atatgctgta atcaaatcat 180cattaaccac aacataatca aattcgctag cggcagcaat ttcgacagcg ctatgctcta 240atctttcttt cttctggaaa tctttctctg aatcccgagc attcaaacgg cgctcaagtt 300cttcttgaga gggagcttga ataaaaatgt gactgccggc atttgcttct tcagagccaa 360agctccttgt acatcaatca cggctatgca gtctcgtgcc gaattc 406

<210>51

<211>602

<212>DNA

<213>衣原体属

<400>51gatccgaatt cggcacgaga tattttagac aaaatcacaa cagacccttc tctaggtttg 60ttgaaagctt ttaacaactt tccaatcact aataaaattc aatgcaacgg gttattcact 120cccaggaaca ttgaaacttt attaggagga actgaaatag gaaaattcac agtcacaccc 180aaaagctctg ggagcatgtt cttagtctca gcagatatta ttgcatcaag aatggaaggc 240ggcgttgttc tagctttggt acgagaaggt gattctaagc cctacgcgat tagttatgga 300tactcatcag gcgttcctaa tttatgtagt ctaagaacca gaattattaa tacaggattg 360actccgacaa cgtattcatt acgtgtaggc ggtttagaaa gcggtgtggt atgggttaat 420gccctttcta atggcaatga tattttagga ataacaaata cttctaatgt atcttttttg 480gaggtaatac ctcaaacaaa cgcttaaaca atttttattg gatttttctt ataggtttta 540tatttagaga aaaaagttcg aattacgggg tttgttatgc aaaataaact cgtgccgaat 600tc 602

<210>52

<211>145

<212>DNA

<213>衣原体属

<400>52gatccgaatt cggcacgagc tcgtgccgat gtgttcaaca gcatccatag gatgggcagt 60caaatatact ccaagtaatt ctttttctct tttcaacaac tccttaggag agcgttggat 120aacattttca gctcgtgccg aattc 145

<210>53

<211>450

<212>DNA

<213>衣原体属

<400>53gatccgaatt cggcacgagg taatcggcac cgcactgctg acactcatct cctcgagctc 60gatcaaaccc acacttggga caagtaccta caacataacg gtccgctaaa aacttccctt 120cttcctcaga atacagctgt tcggtcacct gattctctac cagtccgcgt tcctgcaagt 180ttcgatagaa atcttgcaca atagcaggat gataagcgtt cgtagttctg gaaaagaaat 240ctacagaaat tcccaatttc ttgaaggtat ctttatgaag cttatgatac atgtcgacat 300attcttgata ccccatgcct gccaactctg cattaagggt aattgcgatt ccgtattcat 360cagaaccaca aatatacaaa acctctttgc cttgtagtct ctgaaaacgc gcataaacat 420ctgcaggcaa ataagcctcg tgccgaattc 450

<210>54

<211>716

<212>DNA

<213>衣原体属

<400>54gatcgaaatt cggcacgagc ggcacgagtt ttctgatagc gatttacaat cctttattca 60acttttgcct agagaggcac actatactaa gaagtttctt gggtgtgtgg cacagtcctg 120tcgtcagggg attctgctag aggggtaggg gaaaaaaccc ttattactat gaccatgcgc 180atgtggaatt acattccata gactttcgca tcattcccaa catttacaca gctctacacc 240tcttaagaag aggtgacgtg gattgggtgg ggcagccttg gcaccaaggg attccttttg 300agcttcggac tacctctgct ctctacaccc attaccctgt agatggcaca ttctggctta 360ttcttaatcc caaagatcct gtactttcct ctctatctaa tcgtcagcga ttgattgctg 420ccatccaaaa ggaaaaactg gtgaagcaag ctttaggaac acaatatcga gtagctgaaa 480gctctccatc tccagaggga atcatagctc atcaagaagc ttctactcct tttcctggga 540aaattacttt gatatatccc aataatatta cgcgctgtca gcgtttggcc gaggtatcca 600aaaaatgatc gacaaggagcacgctaaatt tgtacatacc ccaaaatcaa tcagccatct 660aggcaaatgg aatatcaaag taaacagtat acaactgggg atctcgtgcc gaattc 716

<210>55

<211>463

<212>DNA

<213>沙眼衣原体

<400>55tctcaaatcc ttgctttgaa taatccagat atttcaaaaa ccatgttcga taaattcacc 60cgacaaggac tccgtttcgt actagaagcc tctgtatcaa atattgagga tataggagat 120cgcgttcggt taactatcaa tgggaatgtc gaagaatacg attacgttct cgtatctata 180ggacgccgtt tgaatacaga aaatattggc ttggataaag ctggtgttat ttgtgatgaa 240cgcggagtca tccctaccga tgccacaatg cgcacaaacg tacctaacat ttatgctatt 300ggagatatca caggaaaatg gcaacttgcc catgtagctt ctcatcaagg aatcattgca 360gcacggaata taggtggcca taaagaggaa atcgattact ctgctgtccc ttctgtgatc 420tttaccttcc ctgaagtcgc ttcagtaggc ctctccccaa cag 463

<210>56

<211>829

<212>DNA

<213>沙眼衣原体

<400>56gtactatggg atcattagtt ggaagacagg ctccggattt ttctggtaaagccgttgttt 60gtggagaaga gaaagaaatc tctctagcag actttcgtgg taagtatgta gtgctcttct 120tttatcctaa agattttacc tatgtttgtc ctacagaatt acatgctttt caagatagat 180tggtagattt tgaagagcat ggtgcagtcg tccttggttg ctccgttgac gacattgaga 240cacattctcg ttggctcact gtagcgagag atgcaggagg gatagaggga acagaatatc 300ctctgttagc agacccctct tttaaaatat cagaagcttt tggtgttttg aatcctgaag 360gatcgctcgc tttaagagct actttcctta tcgataaaca tggggttatt cgtcatgcgg 420ttatcaatga tcttccttta gggcgttcca ttgacgagga attgcgtatt ttagattcat 480tgatcttctt tgagaaccac ggaatggttt gtccagctaa ctggcgttct ggagagcgtg 540gaatggtgcc ttctgaagag ggattaaaag aatacttcca gacgatggat taagcatctt 600tgaaagtaag aaagtcgtac agatcttgat ctgaaaagag aagaaggctt tttaattttc 660tgcagagagc cagcgaggct tcaataatgt tgaagtctcc gacaccaggc aatgctaagg 720cgacgatatt agttagtgaa gtctgagtat taaggaaatg aaggccaaag aaatagctat 780caataaagaa gccttcttcc ttgactctaa agaatagtat gtcgtatcc 829

<210>57

<211>1537

<212>DNA

<213>沙眼衣原体

<400>57acatcaagaa atagcggact cgcctttagt gaaaaaagct gaggagcaga ttaatcaagc 60acaacaagat attcaaacga tcacacctag tggtttggat attcctatcg ttggtccgag 120tgggtcagct gcttccgcag gaagtgcggc aggagcgttg aaatcctcta acaattcagg 180aagaatttcc ttgttgcttg atgatgtaga caatgaaatg gcagcgattg caatgcaagg 240ttttcgatct atgatcgaac aatttaatgt aaacaatcct gcaacagcta aaagagctaca 300agctatggag gctcagctga ctgcgatgtc agatcaactg gttggtgcgg atggcgagct 360cccagccgaa atacaagcaa tcaaagatgc tcttgcgcaa gctttgaaac aaccatcagc 420agatggttta gctacagcta tgggacaagt ggcttttgca gctgccaagg ttggaggagg 480ctccgcagga acagctggca ctgtccagat gaatgtaaaa cagctttaca agacagcgtt 540ttcttcgact tcttccagct cttatgcagc agcactttcc gatggatatt ctgcttacaa 600aacactgaac tctttatatt ccgaaagcag aagcggcgtg cagtcagcta ttagtcaaac 660tgcaaatccc gcgctttcca gaagcgtttc tcgttctggc atagaaagtc aaggacgcag 720tgcagatgct agccaaagag cagcagaaac tattgtcaga gatagccaaa cgttaggtga 780tgtatatagc cgcttacagg ttctggattc tttgatgtct acgattgtga gcaatccgca 840agcaaatcaa gaagagatta tgcagaagct cacggcatct attagcaaag ctccacaatt 900tgggtatcct gctgttcaga attctgtgga tagcttgcag aagtttgctg cacaattgga 960aagagagttt gttgatgggg aacgtagtct cgcagaatct caagagaatg cgtttagaaa 1020acagcccgct ttcattcaac aggtgttggt aaacattgct tctctattct ctggttatct 1080ttcttaacgt gtgattgaag tttgtgaatt gagggggagc caaaaaagaa tttctttttt 1140ggctcttttt tcttttcaaa ggaatctcgt gtctacagaa gtcttttcaa taataagttc 1200ttagttccaa aagaagaaaa tatataaaag aaaaaactcc taattcattt aaaaagtgct 1260cggcagactt cgtggaaaat gtctgtaaag ctggagggga atcagcagaa agatgcaaga 1320tatccgagaa aaaaggctca ggctcgtgcc gaattcggca cgagactacg aaagaaaggt 1380cttttctttc ggaatctgtc attggatctg cgtaagactt aaagttcggc aacacaggct 1440ctgtcttctc tttaggtttc ttgcgcgaga aaaattttct caagtaacaa gaagatttct 1500ttttacagcc ggcatccggc ttctcgcgaa gtataac 1537

<210>58

<211>463

<212>DNA

<213>沙眼衣原体

<400>58tctcaaatcc ttgctttgaa taatccagat atttcaaaaa ccatgttcga taaattcacc 60cgacaaggac tccgtttcgt actagaagcc tctgtatcaa atattgagga tataggagat 120cgcgttcggt taactatcaa tgggaatgtc gaagaatacg attacgttct cgtatctata 180ggacgccgtt tgaatacaga aaatattggc ttggataaag ctggtgttat ttgtgatgaa 240cgcggagtca tccctaccga tgccacaatg cgcacaaacg tacctaacat ttatgctatt 300ggagatatca caggaaaatg gcaacttgcc catgtagctt ctcatcaagg aatcattgca 360gcacggaata taggtggcca taaagaggaa atcgattact ctgctgtccc ttctgtgatc 420tttaccttcc ctgaagtcgc ttcagtaggc ctctccccaa cag 463

<210>59

<211>552

<212>DNA

<213>沙眼衣原体

<400>59acattcctcc tgctcctcgc ggccatccac aaattgaggt aaccttcgat attgatgcca 60acggaatttt acacgtttct gctaaagatg ctgctagtgg acgcgaacaa aaaatccgta 120ttgaagcaag ctctggatta aaagaagatg aaattcaaca aatgatccgc gatgcagagc 180ttcataaaga ggaagacaaa caacgaaaag aagcttctga tgtgaaaaat gaagccgatg 240gaatgatctt tagagccgaa aaagctgtga aagattacca cgacaaaatt cctgcagaac 300ttgttaaaga aattgaagag catattgaga aagtacgcca agcaatcaaa gaagatgctt 360ccacaacagc tatcaaagca gcttctgatg agttgagtac tcgtatgcaa aaaatcggag 420aagctatgca ggctcaatcc gcatccgcag cagcatcttc tgcagcgaat gctcaaggag 480ggccaaacat taactccgaa gatctgaaaa aacatagttt cagcacacga cctccagcag 540gaggaagcgc ct 552

<210>60

<211>1180

<212>DNA

<213>沙眼衣原体

<400>60atcctagcgg taaaactgct tactggtcag ataaaatcca tacagaagca acacgtactt 60cttttaggag aaaaaatcta taatgctaga aaaatcctga gtaaggatca cttctcctca 120acaacttttt catcttggat agagttagtt tttagaacta agtcttctgc ttacaatgct 180cttgcatatt acgagctttt tataaacctc cccaaccaaa ctctacaaaa agagtttcaa 240tcgatcccct ataaatccgc atatattttg gccgctagaa aaggcgattt aaaaaccaag 300gtcgatgtga tagggaaagt atgtggaatc tcgtgccgaa ttcggcacga gcggcacgag 360gatgtagagt aattagttaa agagctgcat aattatgaca aagcatggaa aacgcattcg 420tggtatccaa gagacttacg atttagctaa gtcgtattct ttgggtgaag cgatagatat 480tttaaaacag tgtcctactg tgcgtttcga tcaaacggtt gatgtgtctg ttaaattagg 540gatcgatcca agaaagagtg atcagcaaat tcgtggttcg gtttctttac ctcacggtac 600aggtaaagtt ttgcgaattt tagtttttgc tgctggagat aaggctgcag aggctattga 660agcaggagcg gactttgttg gtagcgacga cttggtagaa aaaatcaaag gtggatgggt 720tgacttcgat gttgcggttg ccactcccga tatgatgaga gaggtcggaa agctaggaaa 780agttttaggt ccaagaaacc ttatgcctac gcctaaagcc ggaactgtaa caacagatgt 840ggttaaaact attgcggaac tgcgaaaagg taaaattgaa tttaaagctg atcgagctgg 900tgtatgcaac gtcggagttg cgaagctttc tttcgatagt gcgcaaatca aagaaaatgt 960tgaagcgttg tgtgcagcct tagttaaagc taagcccgca actgctaaag gacaatattt 1020agttaatttc actatttcct cgaccatggg gccaggggtt accgtggata ctagggagtt 1080gattgcgtta taattctaag tttaaagagg aaaaatgaaa gaagagaaaa agttgctgct 1140tcgcgaggtt gaagaaaaga taaccgcttc tcggcacgag 1180

<210>61

<211>1215

<212>DNA

<213>沙眼衣原体

<400>61attacagcgt gtgcaggtaa cgacatcatt gcatgatgct tttgatggca ttgatgcggc 60attccttata gggtcagttc ctagaggccc aggaatggag agaagagatc ttctaaagaa 120aaatggggag attgttgcta cgcaaggaaa agctttgaac acaacagcca agcgggatgc 180aaagattttt gttgttggga accctgtgaa taccaattgc tggatagcaa tgaatcatgc 240tcccagatta ttgagaaaga actttcatgc gatgctacga ttggaccaga atcgtatgca 300tagcatgtta tcgcatagag cagaagtacc tttatcggct gtatcacaag ttgtggtttg 360gggaaatcac tccgccaaac aagtgcctga ttttacgcaa gctctgatta atgaccgtcc 420tatcgcagag acgatagcgg atcgtgattg gttagagaat attatggtgc cttctgtaca 480gagtcgtggt agtgcagtaa ttgaagcacg agggaagtct tcggcagctt ctgcagcacg 540agctttagca gaggctgctc gatcaatata tcagccaaaa gaaggactcg tgccgaattc 600ggcacgagta tcgaaattgc aggcatttct agtgaatggt cgtatgctta taaactacgt 660ggtacagact tgagctctca aaagtttgct acagattctt acatcgcaga cccttattct 720aagaatatct actcccctca actatttgga tcccctaaac aagaaaagga ttacgcattt 780agttacctga aatatgagga ttttgactgg gaaggcgaca ctcctttgca ccttccaaaa 840gaaaattact tcatttatga aatgcatgtt cggtcattca cccgagatcc gtcttcccag 900gtttcccatc ctggaacttt ccttggtatc atcgaaaaaa tagaccacct caaacaacta 960ggcgttcatg cagttgaact ccttcctattttcgaattcg atgaaaccgt ccatccattt 1020aaaaatcagg acttccccca cctgtgtaac tattgggggt attcttcggt gaattttttc 1080tgcccctctc gccgttatac ttatggggca gacccttgcg ctccggcccg agagttcaag 1140actcttgtca aagcgttaca ccgtgcggga atcgaagtca ttctcgatgt cgttttcaat 1200catacaggct ttgaa 1215

<210>62

<211>688

<212>DNA

<213>沙眼衣原体

<400>62gtggatccaa aaaagaatct aaaaagccat acaaagattg cgttacttct tgcgatgcct 60ctaacacttt atcagcgtca tctttgagaa gcatctcaat gagcgctttt tcttctctag 120catgccgcac atccgcttct tcatgttctg tgaaatatgc atagtcttca ggattggaaa 180atccaaagta ctcagtcaat ccacgaattt tctctctagc gatacgtgga atttgactct 240cataagaata caaagcagcc actcctgcag ctaaagaatc tcctgtacac caccgcatga 300aagtagctac tttcgctttt gctgcttcac taggctcatg agcctctaac tcttctggag 360taactcctag agcaaacaca aactgcttcc acaaatcaat atgattaggg taaccgttct 420cttcatccat caagttatct aacaataact tacgcgcctc taaatcatcg caacgactat 480gaatcgcaga taaatattta ggaaaggctt tgatatgtaa ataatagtct ttggcacgag 540cctgtaattg ctctttagta agctccccct tcgaccattt cacataaaac gtgtgttcta 600gcatatgctt attttgaata attaaatcta actgatctaa aaaattcata aacacctcca 660tcatttcttt tcttgactcc acgtaacc 688

<210>63

<211>269

<212>DNA

<213>沙眼衣原体

<400>63atgttgaaat cacacaagct gttcctaaat atgctacggt aggatctccc tatcctgttg 60aaattactgc tacaggtaaa agggattgtg ttgatgttat cattactcag caattaccat 120gtgaagcaga gttcgtacgc agtgatccag cgacaactcc tactgctgat ggtaagctag 180tttggaaaat tgaccgctta ggacaaggcg aaaagagtaa aattactgta tgggtaaaac 240ctcttaaaga aggttgctgc tttacagct 269

<210>64

<211>1339

<212>DNA

<213>沙眼衣原体

<400>64cttttattat ggcttctggg gatgatgtca acgatatcga cctgctatct cgaggagatt 60ttaaaattgt tatacagacg gctccagagg agatgcatgg attagcggac tttttggctc 120ccccggcgaa ggatcttggt attctctccg cctgggaagc tggtgagctg cgttacaaac 180agctagttaa tccttaggaa acatttctgg acctatgccc atcacattgg ctccgtgatc 240cacatagaga gtttctcccg taattgcgct agctagggga gagactaaga aggctgctgc 300tgcgcctact tgctcagctt ccattggaga aggtagtgga gcccagtctt ggtagtaatc 360caccattctc tcaataaatc caatagcttt tcctgcacgg ctagctaatg gccctgccga 420gatagtattc actcggactc cccaacgtcg gccggcttcc caagccagta cttttgtatc 480actttctaaa gcagcttttg ctgcgttcat tcctccgcca taccctggaa cagcacgcat 540ggaagcaaga taagttagag agatggtgct agctcctgca ttcataattg ggccaaaatg 600agagagaagg ctgataaagg agtagctgga tgtacttaag gcggcaagat agcctttacg 660agaggtatca agtaatggtt tagcaatttc cggactgttt gctaaagagt gaacaagaat 720atcaatgtgt ccaaaatctt ttttcacctg ttctacaact tcggatacag tgtacccaga 780aagatctttg taacgtttat tttccaaaat ttcctgagga atatcttctg gggtgtcgaa 840actggcatcc atgggataga ttttagcgaa agttagcaat tctccattgg agagttcacg 900agatgcattg aattttccta actcccaaga ttgagagaaa attttataga taggaaccca 960ggtccccaca agtatggttg cgcctgcttc tgctaacatt ttggcaatgc cccagccata 1020cccgttatca tcgcctatgc cggctatgaa agcaattttt cctgttaaat caattttcaa 1080catgagctaa ccccattttg tcttcttgag agaggagagt agcagattct ttattattga 1140gaaacgggcc tcataataca taaggagtag attcactggc tggatccagg tttctagagt 1200aaagagtttc cttgtcaaat tcttatatgg gtagagttaa tcaactgttt tcaagtgatt 1260tatgtttatt ttaaaataat ttgttttaac aactgtttaa tagttttaat ttttaaagtg 1320tgaaaaacag gttttatat 1339

<210>65

<211>195

<212>PRT

<213>沙眼衣原体

<400>65Met Gly Ser Leu Val Gly Arg Gln Ala Pro Asp Phe Ser Gly Lys Ala

5 10 15Val Val Cys Gly Glu Glu Lys Glu Ile Ser Leu Ala Asp Phe Arg Gly

20 25 30Lys Tyr Val Val Leu Phe Phe Tyr Pro Lys Asp Phe Thr Tyr Val Cys

35 40 45Pro Thr Glu Leu His Ala Phe Gln Asp Arg Leu Val Asp Phe Glu Glu

50 55 60His Gly Ala Val Val Leu Gly Cys Ser Val Asp Asp Ile Glu Thr His65 70 75 80Ser Arg Trp Leu Thr Val Ala Arg Asp Ala Gly Gly Ile Glu Gly Thr

85 90 95Glu Tyr Pro Leu Leu Ala Asp Pro Ser Phe Lys Ile Ser Glu Ala Phe

100 105 110Gly Val Leu Asn Pro Glu Gly Ser Leu Ala Leu Arg Ala Thr Phe Leu

115 120 125Ile Asp Lys His Gly Val Ile Arg His Ala Val Ile Asn Asp Leu Pro

130 135 140Leu Gly Arg Ser Ile Asp Glu Glu Leu Arg Ile Leu Asp Ser Leu Ile145 150 155 160Phe Phe Glu Asn His Gly Met Val Cys Pro Ala Asn Trp Arg Ser Gly

165 170 175Glu Arg Gly Met Val Pro Ser Glu Glu Gly Leu Lys Glu Tyr Phe Gln

180 185 190Thr Met Asp

195

<210>66

<211>520

<212>DNA

<213>衣原体属

<400>66gatccgaatt cggcacgagg aggaatggaa gggccctccg attttaaatc tgctaccatg 60ccattcacta gaaactccat aacagcggtt ttctctgatg gcgagtaaga agcaagcatt 120tgatgtaaat tagcgcaatt agagggggat gaggttactt ggaaatataa ggagcgaagc 180gatgaaggag atgtatttgc tctggaagca aaggtttctg aagctaacag aacattgcgt 240cctccaacaa tcgcctgagg attctggctc atcagttgat gctttgcctg aatgagagcg 300gacttaagtt tcccatcaga gggagctatt tgaattagat aatcaagagc tagatccttt 360attgtgggat cagaaaattt acttgtgagc gcatcgagaa tttcgtcaga agaagaatca 420tcatcgaacg aatttttcaa tcctcgaaaa tcttctccag agacttcgga aagatcttct 480gtgaaacgat cttcaagagg agtatcgcct ttttcctctg 520

<210>67

<211>276

<212>DNA

<213>衣原体属

<400>67gatccgaatt cggcacgagg tattgaagga gaaggatctg actcgatcta tgaaatcatg 60atgcctatct atgaagttat gaatatggat ctagaaacac gaagatcttt tgcggtacag 120caagggcact atcaggaccc aagagcttca gattatgacc tcccacgtgc tagcgactat 180gatttgccta gaagcccata tcctactcca cctttgcctt ctagatatca gctacagaat 240atggatgtag aagcagggtt ccgtgaggca gtttat 276

<210>68

<211>248

<212>DNA

<213>衣原体属

<400>68gatccgaatt cggcacgagg tgttcaagaa tatgtccttc aagaatgggt taaattgaaa 60gatctaccgg tagaagagtt gctagaaaaa cgatatcaga aattccgaac gataggtcta 120tatgaaactt cttctgaaag cgattctgag gcataagaag catttagttt tattcggttt 180ttctctttta tccatattag ggctaacgat aacgtctcaa gcagaaattt tttctctagg 240tcttattg 248

<210>69

<211>715

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>34

<223>n＝A，T，C或G

<400>69gatccgaatt cggcacgaga aggtagatcc gatntcagca aaagtgctcc taaaggaaga 60ttccttcggt atcctgcagc aaataaggtg gcacactcca tctcggacag tttgagcttt 120attttcatat agttttcgac ggaactcttt attaaactcc caaaaccgaa tgttagtcgt 180gtgggtgatg cctatatggt aagggaggtt tttggcttcg agaatattgg tgatcatttt 240ttgtacgaca aaattagcta atgcagggac ctctgggggg aagtatgcat ctgatgttcc 300atcttttcgg atgctagcaa cagggacaaa ataatctcct atttggtagt gggatcttaa 360gcctccgcac atgcccaaca tgatcgctgc tgtagcattg ggaaggaaag aacacagatc 420tacggtaaga gctgctcctg gagagcctaa tttaaaatcg atgattgagg tgtgaatttg 480aggcgcatgc gctgccgaaa acatggatcc tcgagaaaca gggacctgat agatttcagc 540gaaaacatcc acggtaatac ccmaaattag taagaaggag atagggctgg aactcttgaa 600tggtagagcc ggtatagcgc tctagcatgt cacaggcgat tgtttcttcg ctgatttttt 660tatgttgatg ggtcataaat cacagatatt ataatggtta gagaatcttt ttttc 715

<210>70

<211>323

<212>DNA

<213>衣原体属

<400>70gatccgaatt cggcacgagc agaacgtaaa cagcacactt aaaccgtgta tgaggtttaa 60cactgtttgg caagcaaaca accattcctc tttccacatc gttcttacca atacctctga 120ggagcaatcc aacattctct cctgcacgac cttctgggag ttcttttctg aacatttcaa 180ccccagtaac aatcgtttct ttagtatctc taagaccgac caactgaact ttatcggaaa 240ctttaacaat tccacgctca atacgtccag ttactacagt tcctcgtccg gagatagaga 300acacgtcctc aatgggcatt aag 323

<210>71

<211>715

<212>DNA

<213>衣原体属

<400>71gatccgaatt cggcacgagg aaaaaaagat tctctaacca ttataatatc tgtgatttat 60gacccatcaa cataaaaaaa tcagcgaaga aacaatcgcc tgtgacatgc tagagcggct 120ataccggctc taccattcaa gagttccagc cctatctcct tcttactaat tttgggtatt 180acgtggatgt tttcgctgaa atctatcagg tccctgtttc tcgaggatcc atgttttcgg 240gcagcgcatg cgcctcaaat tcacacctca atcatcgatt ttaaattagg ctctccagga 300gcagctctta ccgtagatct gtgttctttc cttcccaatg ctacagcagc gatcatgttg 360ggcatgtgcg gaggcttaag atcccactac caaataggag attattttgt ccctgttgct 420agcatccgaa aagatggaac atcagatgca tacttccccc cagaggtccc tgcattagct 480aattttgtcg tacaaaaaat gatcaccaat attctcgaag ccaaaaacct cccttaccat 540ataggcatca cccacacgac taacattcgg ttttgggagt ttaataaaga gttccgtcga 600aaactatatg aaaataaagc tcaaactgtc gagatggagt gtgccacctt atttgctgca 660ggataccgaa ggaatcttcc tttaggagca cttttgctga tatcggatct acctt 715

<210>72

<211>641

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>550，559，575，583，634，638

<223>n＝A，T，C或G

<400>72gatccgaatt cggcacgaga tctcctcgag ctcgatcaaa cccacacttg ggacaagtac 60ctacaacata acggtccgct aaaaacttcc cttcttcctc agaatacagc tgttcggtca 120cctgattctc taccagtccg cgttcctgca agtttcgata gaaatcttgc acaatagcag 180gatgataagc gttcgtagtt ctggaaaaga aatctacaga aattcccaat ttcttgaagg 240tatctttatg aagcttatga tacatgtcga catattcttg ataccccatg cctgccaact 300ctgcattaag ggtaattgcg attccgtatt catcagaacc acaaatat2c aaaacctctt 360tgccttgtag tctctgaaaa cgcgcataaa catctgcagg caaataagca ccggtaatat 420gtccaaaatg caaaggacca tttgcgtaag gcaacgcaga agtaataaga atacgggaag 480attccactat ttcacgtcgc tccagttgta cagagaagga tcttttcttc tggatgttcc 540gaaaccttgn tctcttcgnc tctctcctgt agcanacaaa tgnctctctc gacatctctt 600tcagcgtatt cggactgatg ccctaaagat cccnggangt t 641

<210>73

<211>584

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>460，523，541，546

<223>n＝A，T，C或G

<400>73gaattcggca cgagacattt ctagaatgga accggcaaca aacaaaaact ttgtatctga 60agatgacttt aagcaatctt tagataggga agattttttg gaatgggtct ttttatttgg 120gacttattac ggaacgagta aggcggagat ttctagagtt ctgcaaaagg gtaagcactg 180catagccgtg attgatgtac aaggagcttt ggctctgaag aagcaaatgc cggcagtcac 240tatttttatt caagctccct ctcaagaaga acttgagcgc cgtttgaatg ctcgggattc 300agagaaagat ttccagaaga aagaaagatt agagcatagc gctgtcgaaa ttgctgccgc 360tagcgaattt gattatgttg tggttaatga tgatttgatt acagcatatc aagttttaag 420aagtattttt atagctgaag aacataggat gagtcatggn tagaaaagat cgtttaacta 480atgaaagact gaataagcta tttgatagcc cctttagttt ggntaattac gtaattaagc 540nagctnagaa caaaattgct agaggagatg ttcgttcttc taac 584

<210>74

<211>465

<212>DNA

<213>衣原体属

<400>74gatccgaatt cggcacgagc tcgtgccgtt tgggatcgtg taatcgcatc ggagaatggt 60taagaaatta ttttcgagtg aaagagctag gcgtaatcat tacagatagc catactactc 120caatgcggcg tggagtactg ggtatcgggc tgtgttggta tggattttct ccattacaca 180actatatagg atcgctagat tgtttcggtc gtcccttaca gatgacgcaa agtaatcttg 240tagatgcctt agcagttgcg gctgttgttt gtatgggaga ggggaatgag caaacaccgt 300tagcggtgat agagcaggca cctaatatgg tctaccattc atatcctact tctcgagaag 360agtattgttc tttgcgcata gatgaaacag aggacttata cggacctttt ttgcaagcgg 420ttaccgtgga gtcaagaaaa gaaatgatgg aggtgtttat gaatt 465

<210>75

<211>545

<212>DNA

<213>衣原体属

<400>75gaattcggca cgagatgaaa agttagcgtc acaggggatt ctcctaccaa agaattccga 60aaagttttct tccaaaaacc tcttcctctc ttgattagtg atccctctgc aactacttta 120ctatatgttc tgtgaaatat gcatagtctt caggattgga aaatccaaag tactcagtca 180atccacgaat tttctctcta gcgatacgtg gaatttgact ctcataagaa tacaaagcag 240ccactcctgc agctaaagaa tctcctgtac accaccgcat gaaagtagct actttcgctt 300ttgctgcttc actaggctca tgagcctcta actcttctgg agtaactcct agagcaaaca 360caaactgctt ccacaaatca atatgattag ggtaaccgtt ctcttcatcc atcaagttat 420ctaacaataa cttacgcgcc tctaaatcat cgcaacgact atgaatcgca gataaatatt 480taggaaaggc tttgatatgt aaataatagt ctttggcata cgcctgtaat tgctctttag 540taagc 545

<210>76

<211>797

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>788，789

<223>n＝A，T，C或G

<400>76gatccgaatt cggcacgaga tacgctagat gcgataaatg cggataatga ggattatcct 60aaaccaggtg acttcccacg atcttccttc tctagtacgc ctcctcatgc tccagtacct 120caatctgaga ttccaacgtc acctacctca acacagcctc catcacccta acttgtaaaa 180actgtaataa aaagagcgcg cttcctttat gcaaaatcaa tttgaacaac tccttactga 240attagggact caaatcaaca gccctcttac tcctgattcc aataatgcct gtatagttcg 300ctttggatac aacaatgttg ctgtacaaat tgaagaggat ggtaattcag gatttttagt 360tgctggagtc atgcttggaa aacttccaga gaataccttt agacaaaaaa ttttcaaagc 420tgctttgtct atcaatggat ctccgcaatc taatattaaa ggcactctag gatacggtga 480aatctctaac caactctatc tctgtgatcg gcttaacatg acctatctaa atggagaaaa 540gctcgcccgt tacttagttc ttttttcgca gcatgccaat atctggatgc aatctatctc 600aaaaggagaa cttccagatt tacatgctct aggtatgtat cacctgtaaa ttatgccgtc 660attatcccaa tcccgacgta tcatccagca atcttccatt cgaaagattt ggaatcagat 720agatacttct cctaagcatg ggggtatgcg taccggttat ttttctcttc atactcaaaa 780aaagttgnng gggaata 797

<210>77

<211>399

<212>DNA

<213>衣原体属

<400>77catatgcatc accatcacca tcacatgcca cgcatcattg gaattgatat tcctgcaaag 60aaaaagttaa aaataagtct gacatatatt tatggaatag gatcagctcg ttctgatgaa 120atcattaaaa agttgaagtt agatcctgag gcaagagcct ctgaattaac tgaagaagaa 180gtaggacgac tgaactctct gctacaatca gaatataccg tagaagggga tttgcgacgt 240cgtgttcaat cggatatcaa aagattgatc gccatccatt cttatcgagg tcagagacat 300agactttctt taccagtaag aggacaacgt acaaaaacta attctcgtac tcgaaaaggt 360aaaagaaaaa cagtcgcagg taagaagaaa taagaattc 399

<210>78

<211>285

<212>DNA

<213>衣原体属

<400>78atgcatcacc atcaccatca catgagtcaa aaaaataaaa actctgcttt tatgcatccc 60gtgaatattt ccacagattt agcagttata gttggcaagg gacctatgcc cagaaccgaa 120attgtaaaga aagtttggga atacattaaa aaacacaact gtcaggatca aaaaaataaa 180cgtaatatcc ttcccgatgc gaatcttgcc aaagtctttg gctctagtga tcctatcgac 240atgttccaaa tgaccaaagc cctttccaaa catattgtaa aataa 285

<210>79

<211>950

<212>DNA

<213>衣原体属

<400>79aaattaactc gagcacaaat tacggcaatt gctgagcaaa agatgaagga catggatgtc 60gttcttttag agtccgccga gagaatggtt gaagggactg cccgaagcat gggtgtagat 120gtagagtaat tagttaaaga gctgcataat tatgacaaag catggaaaac gcattcgtgg 180tatccaagag acttacgatt tagctaagtc gtattctttg ggtgaagcga tagatatttt 240aaaacagtgt cctactgtgc gtttcgatca aacggttgat gtgtctgtta aattagggat 300cgatccaaga aagagtgatc agcaaattcg tggttcggtt tctttacctc acggtacagg 360taaagttttg cgaattttag tttttgctgc tggagataag gctgcagagg ctattgaagc 420aggagcggac tttgttggta gcgacgactt ggtagaaaaa atcaaaggtg gatgggttga 480cttcgatgtt gcggttgcca ctcccgatat gatgagagag gtcggaaagc taggaaaagt 540tttaggtcca agaaacctta tgcctacgcc taaagccgga actgtaacaa cagatgtggt 600taaaactatt gcggaactgc gaaaaggtaa aattgaattt aaagctgatc gagctggtgt 660atgcaacgtc ggagttgcga agctttcttt cgatagtgcg caaatcaaag aaaatgttga 720agcgttgtgt gcagccttag ttaaagctaa gcccgcaact gctaaaggac aatatttagt 780taatttcact atttcctcga ccatggggcc aggggttacc gtggatacta gggagttgat 840tgcgttataa ttctaagttt aaagaggaaa aatgaaagaa gagaaaaagt tgctgcttcg 900cgaggttgaa gaaaagataa ccgcttctca aggttttatt ttgttgagat 950

<210>80

<211>395

<212>DNA

<213>衣原体属

<400>80tttcaaggat tttgttttcc cgatcatctt actaaatgca gctccaacaa tcacatcatg 60ggctggttta gcatctaagg caacagaagc tcctctgctg taataagtga attcttcaga 120agtaggtgtt cctacttgcg atagcatcgt tcctagtcct gatatccaca ggttgttata 180gctaacttca tcaaagcgag ctagattcat tttatcgttg agcaagcctt gtttgactgt 240gaccattgac atttgagatc ccagaatcga gttcgcatag aaatgattgt ctctaggtac 300ataagcccat tgtctataag agtcaaattt ccagagcgct gagatcgttc cattttgtag 360ttgatcagga tccagagtga gtgttcctgt atatc 395

<210>81

<211>2085

<212>DNA

<213>衣原体属

<400>81atttggcgaa ggagtttggg ctacggctat taataaatca ttcgtgttcg ctgcctccaa 60gaccagattg tgtactttct tatgaagaat ctcctattga gcaaatgttg cgttggggag 120agtctcagtt agaacaattt gctcaagtag gtttagatac aagttggcaa gttgttttcg 180atccaggaat aggatttggg aagactcccg ttcagtcgat gttattgatg gatggagtaa 240agcagtttaa acgtgtttta gagtgtcctg tattaatagg ccattctaga aaatcgtgtt 300tgagtatgtt gggccgattt aatagtgacg atcgtgattg ggaaacgatc ggctgttctg 360tatctcttca tgatcgagga gttgattatc tacgtgtgca tcaggttgaa ggtaacagac 420gtgccttagc cgctgctgct tgggctggta tgtttgtatg atccaagcaa caggtatcgt 480tgctattgat cccagaggag tgatgggagc tttaggcaag ctcccttgga gttatcccga 540agatctacgt ttttttgcag aaaccattcg aaatcatccc atcattatgg gacgaaagac 600ttgggagtct cttccagaca agtataagca tgggcgggat atcgttgtct tttctcgcag 660gatgcatcca ccacaatgca taggagtttc ttcctttgca gagtatggga cactatcttt 720gaatcatccg tttttaattg ggggagcgga gctctttgaa agttttttcc aacaaaacct 780tctgaaagct tgttttgtca cacatatcaa aaagaaatat tggggcgata ctttcttccc 840tatcacgcga ttatcaggat ggaagaagga atgtatttgt aatacagagg atttcagtat 900ttattattat gaaaataact ccgatcaaaa cacgtaaagt atttgcacat gattcgcttc 960aagagatctt gcaagaggct ttgccgcctc tgcaagaacg gagtgtggta gttgtctctt 1020caaagattgt gagtttatgt gaaggcgctg tcgctgatgc aagaatgtgc aaagcagagt 1080tgataaaaaa agaagcggat gcttatttgt tttgtgagaa aagcgggata tatctaacga 1140aaaaagaagg tattttgatt ccttctgcag ggattgatga atcgaatacg gaccagcctt 1200ttgttttata tcctaaagat attttgggat cgtgtaatcg catcggagaa tggttaagaa 1260attattttcg agtgaaagag ctaggcgtaa tcattacaga tagccatact actccaatgc 1320ggcgtggagt actgggtatc gggctgtgtt ggtatggatt ttctccatta cacaactata 1380taggatcgct agattgtttc ggtcgtccct tacagatgac gcaaagtaat cttgtagatg 1440ccttagcagt tgcggctgtt gtttgtatgg gagaggggaa tgagcaaaca ccgttagcgg 1500tgatagagca ggcacctaat atggtctacc attcatatcc tacttctcga gaagagtatt 1560gttctttgcg catagatgaa acagaggact tatacggacc ttttttgcaa gcggttacgt 1620ggagtcaaga aaagaaatga tggaggtgtt tatgaatttt ttagatcagt tagatttaat 1680tattcaaaat aagcatatgc tagaacacac gttttatgtg aaatggtcga agggggagct 1740tactaaagag caattacagg cgtatgccaa agactattat ttacatatca aagcctttcc 1800taaatattta tctgcgattc atagtcgttg cgatgattta gaggcgcgta agttattgtt 1860agataacttg atggatgaag agaacggtta ccctaatcat attgatttgt ggaagcagtt 1920tgtgtttgct ctaggagtta ctccagaaga gttagaggct catgagccta gtgaagcagc 1980aaaagcgaaa gtagctactt tcatgcggtg gtgtacagga gattctttag ctgcaggagt 2040ggctgctttg tattcttatg agagtcaaat tccacgtatc gcctc 2085

<210>82

<211>405

<212>DNA

<213>衣原体属

<400>82ttcatcggtc tagttcgcta ttctactctc caatggttcc gcatttttgg gcagagcttc 60gcaatcatta tgcaacgagt ggtttgaaaa gcgggtacaa tattgggagt accgatgggt 120ttctccctgt cattgggcct gttatatggg agtcggaggg tcttttccgc gcttatattt 180cttcggtgac tgatggggat ggtaagagcc ataaagtagg atttctaaga attcctacat 240atagttggca ggacatggaa gattttgatc cttcaggacc gcctccttgg gaagaattgt 300attggctcca taaagggagg agaaaacttc gatataggga atcgtatcaa ggtgaaagta 360gcaaaaaata aattagctcc tccattccga actgcagaat ttgat 405

<210>83

<211>379

<212>DNA

<213>衣原体属

<400>83tataccattc gtttgaaagt gcctttgacg ggagaaagtg tttttgaaga tcaatgcaaa 60ggtcgtgtcg ttttcccttg ggcagatgtt gacgatcaag ttttggttaa atcagacggg 120ttccctacgt atcactttgc taatgtagtt gatgatcatt tgatggggat tacccatgtg 180ttgcgagggg aagagtggtt aagttctaca cctaaacacc ttcttcttta caaagctttt 240gggtgggagc ctccgcagtt tttccatatg ccgcttcttc taaatcctga tggaagtaag 300ctttccaaga gaaagaatcc tacttctatt ttttactatc gggatgctgg atacaaaaaa 360gaagcgttca tgaatttcc 379

<210>84

<211>715

<212>DNA

<213>衣原体属

<400>84tcaatcctgt attaataatt ctggttctta gactacataa attaggaacg cctgatgagt 60atccataact aatcgcgtag ggcttagaat caccttctcg taccaaagct agaacaacgc 120cgccttccat tcttgatgca ataatatctg ctgagactaa gaacatgctc ccagagcttt 180tgggtgtgac tgtgaatttt cctatttcag ttcctcctaa taaagtttca atgttcctgg 240gagtgaataa cccgttgcat tgaattttat tagtgattgg aaagttgtta aaagctttca 300acaaacctag agaagggtct gttgtgattt tgtctaaaat atcttggact gtactatcaa 360caatagtatc agcaattcca ccaagaattt gatctcccaa cttttctaga ataagctggt 420aagctttttc cgcatccaaa ccaattgtaa tagaagcatt ggttgatgga ttattggaga 480ctgttaaaga tattccatca gaagctgtca ttttggctgc gacaggtgtt gatgttgtcc 540caaggattat ttgctggtcc ttgagcggct ctgtcatttg cccaactttg atattatcag 600caaagacgca gttttgagtg ttatacaaat aaaaaccaga atttcccatt ttaaaactct 660tttttatttt gagctttaaataaattaggt ttttagtttc aagtttgcta ttaat 715

<210>85

<211>476

<212>DNA

<213>衣原体属

<400>85ctcgtgccgc tcgtgccgct cgtgccggtc ttttagaaga gcgtgaagct ttaaataatt 60cgattacgtt tatcatggat aagcgtaatt ggatagaaac cgagtctgaa caggtacaag 120tggttttcag agatagtaca gcttgcttag gaggaggcgc tattgcagct caagaaattg 180tttctattca gaacaatcag gctgggattt ccttcgaggg aggtaaggct agtttcggag 240gaggtattgc gtgtggatct ttttcttccg caggcggtgc ttctgtttta gggactattg 300atatttcgaa gaatttaggc gcgatttcgt tctctcgtac tttatgtacg acctcagatt 360taggacaaat ggagtaccag ggaggaggag ctctatttgg tgaaaatatt tctctttctg 420agaatgctgg tgtgctcacc tttaaagaca acattgtgaa gacttttgct tcgaat 476

<210>86

<211>1551

<212>DNA

<213>衣原体属

<400>86gcgtatcgat atttcttctg ttacattctt tatagggatt ctgttggctg ttaatgcgct 60aacctactct catgtattac gggatttatc tgtgagtatg gatgcgctgt tttctcgtaa 120cacgcttgct gttcttttag gtttagtctc tagcgtttta gataatgtgc cattagtcgc 180tgcaacaata ggtatgtatg acttacctat gaacgatcct ctttggaaac tcattgccta 240tacagcaggc acagggggaa gtattctcat cattggatcc gctgcaggtg ttgcctacat 300gggaatggaa aaagtgagtt tcggctggta tgtcaaacac gcttcttgga ttgctttagc 360cagttatttt ggaggtctag cagtctattt tctaatggaa aattgtgtga atttgttcgt 420ttgaggtagt cagtatggca gagtttcttt aaaaattctt ttaataaaag ggttctctgc 480ctattctagg cccctttttg aatggaaaaa tgggtttttg gagaacatcg attatgaaaa 540tgaataggat ttggctatta ctgcttacct tttcttctgc catacattct cctgtacgag 600gagaaagctt ggtttgcaag aatgctcttc aagatttgag ttttttagag catttattac 660aggttaaata tgctcctaaa acatggaaag agcaatactt aggatgggat cttgttcaaa 720gctccgtttc tgcacagcag aagcttcgta cacaagaaaa tccatcaaca agtttttgcc 780agcaggtcct tgctgatttt atcggaggat taaatgactt tcacgctgga gtaactttct 840ttgcgataga aagtgcttac cttccttata ccgtacaaaa aagtagtgac ggccgtttct 900actttgtaga tatcatgact ttttcttcag agatccgtgt tggagatgag ttgctagagg 960tggatggggc gcctgtccaa gatgtgctcg ctactctata tggaagcaat cacaaaggga 1020ctgcagctga agagtcggct gctttaagaa cactattttc tcgcatggcc tctttagggc 1080acaaagtacc ttctgggcgc actactttaa agattcgtcg tccttttggt actacgagag 1140aagttcgtgt gaaatggcgt tatgttcctg aaggtgtagg agatttggct accatagctc 1200cttctatcag ggctccacag ttacagaaat cgatgagaag ctttttccct aagaaagatg 1260atgcgtttca tcggtctagt tcgctattct actctccaat ggttccgcat ttttgggcag 1320agcttcgcaa tcattatgca acgagtggtt tgaaaagcgg gtacaatatt gggagtaccg 1380atgggtttct ccctgtcatt gggcctgtta tatgggagtc ggagggtctt ttccgcgctt 1440atatttcttc ggtgactgat ggggatggta agagccataa agtaggattt ctaagaattc 1500ctacatatag ttggcaggac atggaagatt ttgatccttc aggaccgcct c 1551

<210>87

<211>3031

<212>DNA

<213>衣原体属

<400>87atgtaggccc tcaagcggtt ttattgttag accaaattcg agatctattc gttgggtcta 60aagatagtca ggctgaagga cagtataggt taattgtagg agatccaagt tctttccaag 120agaaagatgc agatactctt cccgggaagg tagagcaaag tactttgttc tcagtaacca 180atcccgtggt tttccaaggt gtggaccaac aggatcaagt ctcttcccaa gggttaattt 240gtagttttac gagcagcaac cttgattctc cccgtgacgg agaatctttt ttaggtattg 300cttttgttgg ggatagtagt aaggctggaa tcacattaac tgacgtgaaa gcttctttgt 360ctggagcggc tttatattct acagaagatc ttatctttga aaagattaag ggtggattgg 420aatttgcatc atgttcttct ctagaacagg ggggagcttg tgcagctcaa agtattttga 480ttcatgattg tcaaggattg caggttaaac actgtactac agccgtgaat gctgaggggt 540ctagtgcgaa tgatcatctt ggatttggag gaggcgcttt ctttgttacg ggttctcttt 600ctggagagaa aagtctctat atgcctgcag gagatatggt agttgcgaat tgtgatgggg 660ctatatcttt tgaaggaaac agcgcgaact ttgctaatgg aggagcgatt gctgcctctg 720ggaaagtgct ttttgtcgct aatgataaaa agacttcttt tatagagaac cgagctttgt 780ctggaggagc gattgcagcc tcttctgata ttgcctttca aaactgcgca gaactagttt 840tcaaaggcaa ttgtgcaatt ggaacagagg ataaaggttc tttaggtgga ggggctatat 900cttctctagg caccgttctt ttgcaaggga atcacgggat aacttgtgat aataatgagt 960ctgcttcgca aggaggcgcc atttttggca aaaattgtca gatttctgac aacgaggggc 1020cagtggtttt cagagatagt acagcttgct taggaggagg cgctattgca gctcaagaaa 1080ttgtttctat tcagaacaat caggctggga tttccttcga gggaggtaag gctagtttcg 1140gaggaggtat tgcgtgtgga tctttttctt ccgcaggcgg tgcttctgtt ttagggacta 1200ttgatatttc gaagaattta ggcgcgattt cgttctctcg tactttatgt acgacctcag 1260atttaggaca aatggagtac cagggaggag gagctctatt tggtgaaaat atttctcttt 1320ctgagaatgc tggtgtgctc acctttaaag acaacattgt gaagactttt gcttcgaatg 1380ggaaaattct gggaggagga gcgattttag ctactggtaa ggtggaaatt accaataatt 1440ccggaggaat ttcttttaca ggaaatgcga gagctccaca agctcttcca actcaagagg 1500agtttccttt attcagcaaa aaagaagggc gaccactctc ttcaggatat tctgggggag 1560gagcgatttt aggaagagaa gtagctattc tccacaacgc tgcagtagta tttgagcaaa 1620atcgtttgca gtgcagcgaa gaagaagcga cattattagg ttgttgtgga ggaggcgctg 1680ttcatgggat ggatagcact tcgattgttg gcaactcttc agtaagattt ggtaataatt 1740acgcaatggg acaaggagtc tcaggaggag ctcttttatc taaaacagtg cagttagctg 1800gaaatggaag cgtcgatttt tctcgaaata ttgctagttt gggaggacgc aatgttctgt 1860tagcttcaga aacctttgct tccagagcaa atacatctcc ttcatcgctt cgctccttat 1920atttccaagt aacctcatcc ccctctaatt gcgctaattt acatcaaatg cttgcttctt 1980actcgccatc agagaaaacc gctgttatgg agtttctagt gaatggcatg gtagcagatt 2040taaaatcgga gggcccttcc attcctcctg caaaattgca agtatatatg acggaactaa 2100gcaatctcca agccttacac tctgtagata gcttttttga tagaaatatt gggaacttgg 2160aaaatagctt aaagcatgaa ggacatgccc ctattccatc cttaacgaca ggaaatttaa 2220ctaaaacctt cttacaatta gtagaagata aattcccttc ctcttccaaa gctcaaaagg 2280cattaaatga actggtaggc ccagatactg gtcctcaaac tgaagtttta aacttattct 2340tccgcgctct taatggctgt tcgcctagaa tattctctgg agctgaaaaa aaacagcagc 2400tggcatcggt tatcacaaat acgctagatg cgataaatgc ggataatgag gattatccta 2460aaccaggtga cttcccacga tcttccttct ctagtacgcc tcctcatgct ccagtacctc 2520aatctgagat tccaacgtca cctacctcaa cacagcctcc atcaccctaa cttgtaaaaa 2580ctgtaataaa aagagcgcgc ttcctttatg caaaatcaat ttgaacaact ccttactgaa 2640ttagggactc aaatcaacag ccctcttact cctgattcca ataatgcctg tatagttcgc 2700tttggataca acaatgttgc tgtacaaatt gaagaggatg gtaattcagg atttttagtt 2760gctggagtca tgcttggaaa acttccagag aataccttta gacaaaaaat tttcaaagct 2820gctttgtcta tcaatggatc tccgcaatct aatattaaag gcactctagg atacggtgaa 2880atctctaacc aactctatct ctgtgatcgg cttaacatga cctatctaaa tggagaaaag 2940ctcgcccgtt acttagttct tttttcgcag catgccaata tctggatgca atctatctca 3000aaaggagaac ttccagattt acatgctcta g 3031

<210>88

<211>976

<212>DNA

<213>衣原体属

<400>88aggtggatgg ggcgcctgtc caagatgtgc tcgctactct atatggaagc aatcacaaag 60ggactgcagc tgaagagtcg gctgctttaa gaacactatt ttctcgcatg gcctctttag 120ggcacaaagt accttctggg cgcactactt taaagattcg tcgtcctttt ggtactacga 180gagaagttcg tgtgaaatgg cgttatgttc ctgaaggtgt aggagatttg gctaccatag 240ctccttctat cagggctcca cagttacaga aatcgatgag aagctttttc cctaagaaag 300atgatgcgtt tcatcggtct agttcgctat tctactctcc aatggttccg catttttggg 360cagagcttcg caatcattat gcaacgagtg gtttgaaaag cgggtacaat attgggagta 420ccgatgggtt tctccctgtc attgggcctg ttatatggga gtcggagggt cttttccgcg 480cttatatttc ttcggtgact gatggggatg gtaagagcca taaagtagga tttctaagaa 540ttcctacata tagttggcag gacatggaag attttgatcc ttcaggaccg cctccttggg 600aagaatttgc taagattatt caagtatttt cttctaatac agaagctttg attatcgacc 660aaacgaacaa cccaggtggt agtgtccttt atctttatgc actgctttcc atgttgacag 720accgtccttt agaacttcct aaacatagaa tgattctgac tcaggatgaa gtggttgatg 780ctttagattg gttaaccctg ttggaaaacg tagacacaaa cgtggagtct cgccttgctc 840tgggagacaa catggaagga tatactgtgg atctacaggt tgccgagtat ttaaaaagct 900ttggacgtca agtattgaat tgttggagta aaggggatat cgagttatca acacctattc 960ctctttttgg ttttga 976

<210>89

<211>94

<212>PRT

<213>衣原体属

<400>89Met His His His His His His Met Ser Gln Lys Asn Lys Asn Ser Ala

5 10 15Phe Met His Pro Val Asn Ile Ser Thr Asp Leu Ala Val Ile Val Gly

20 25 30Lys Gly Pro Met Pro Arg Thr Glu Ile Val Lys Lys Val Trp Glu Tyr

35 40 45Ile Lys Lys His Asn Cys Gln Asp Gln Lys Asn Lys Arg Asn Ile Leu

50 55 60Pro Asp Ala Asn Leu Ala Lys Val Phe Gly Ser Ser Asp Pro Ile Asp65 70 75 80Met Phe Gln Met Thr Lys Ala Leu Ser Lys His Ile Val Lys

85 90

<210>90

<211>474

<212>PRT

<213>衣原体属

<400>90Met Ala Ser His His His His His His Met Asn Glu Ala Phe Asp Cys

5 10 15Val Val Ile Gly Ala Gly Pro Gly Gly Tyr Val Ala Ala Ile Thr Ala

20 25 30Ala Gln Ala Gly Leu Lys Thr Ala Leu Ile Glu Lys Arg Glu Ala Gly

35 40 45Gly Thr Cys Leu Asn Arg Gly Cys Ile Pro Ser Lys Ala Leu Leu Ala

50 55 60Gly Ala Glu Val Val Thr Gln Ile Arg His Ala Asp Gln Phe Gly Ile65 70 75 80His Val Glu Gly Phe Ser Ile Asn Tyr Pro Ala Met Val Gln Arg Lys

85 90 95Asp Ser Val Val Arg Ser Ile Arg Asp Gly Leu Asn Gly Leu Ile Arg

100 105 110Ser Asn Lys Ile Thr Val Phe Ser Gly Arg Gly Ser Leu Ile Ser Ser

115 120 125Thr Glu Val Lys Ile Leu Gly Glu Asn Pro Ser Val Ile Lys Ala His

130 135 140Ser Ile Ile Leu Ala Thr Gly Ser Glu Pro Arg Ala Phe Pro Gly Ile145 150 155 160Pro Phe Ser Ala Glu Ser Pro Arg Ile Leu Cys Ser Thr Gly Val Leu

165 170 175Asn Leu Lys Glu Ile Pro Gln Lys Met Ala Ile Ile Gly Gly Gly Val

180 185 190Ile Gly Cys Glu Phe Ala Ser Leu Phe His Thr Leu Gly Ser Glu Val

195 200 205Ser Val Ile Glu Ala Ser Ser Gln Ile Leu Ala Leu Asn Asn Pro Asp

210 215 220Ile Ser Lys Thr Met Phe Asp Lys Phe Thr Arg Gln Gly Leu Arg Phe225 230 235 240Val Leu Glu Ala Ser Val Ser Asn Ile Glu Asp Ile Gly Asp Arg Val

245 250 255Arg Leu Thr Ile Asn Gly Asn Val Glu Glu Tyr Asp Tyr Val Leu Val

260 265 270Ser Ile Gly Arg Arg Leu Asn Thr Glu Asn Ile Gly Leu Asp Lys Ala

275 280 285Gly Val Ile Cys Asp Glu Arg Gly Val Ile Pro Thr Asp Ala Thr Met

290 295 300Arg Thr Asn Val Pro Asn Ile Tyr Ala Ile Gly Asp Ile Thr Gly Lys305 310 315 320Trp Gln Leu Ala His Val Ala Ser His Gln Gly Ile Ile Ala Ala Arg

325 330 335Asn Ile Gly Gly His Lys Glu Glu Ile Asp Tyr Ser Ala Val Pro Ser

340 345 350Val Ile Phe Thr Phe Pro Glu Val Ala Ser Val Gly Leu Ser Pro Thr

355 360 365Ala Ala Gln Gln Gln Lys Ile Pro Val Lys Val Thr Lys Phe Pro Phe

370 375 380Arg Ala Ile Gly Lys Ala Val Ala Met Gly Glu Ala Asp Gly Phe Ala385 390 395 400Ala Ile Ile Ser His Glu Thr Thr Gln Gln Ile Leu Gly Ala Tyr Val

405 410 415Ile Gly Pro His Ala Ser Ser Leu Ile Ser Glu Ile Thr Leu Ala Val

420 425 430Arg Asn Glu Leu Thr Leu Pro Cys Ile Tyr Glu Thr Ile His Ala His

435 440 445Pro Thr Leu Ala Glu Val Trp Ala Glu Ser Ala Leu Leu Ala Val Asp

450 455 460Thr Pro Leu His Met Pro Pro Ala Lys Lys465 470

<210>91

<211>129

<212>PRT

<213>衣原体属

<400>91Met His His His His His His Met Pro Arg Ile Ile Gly Ile Asp Ile

5 10 15Pro Ala Lys Lys Lys Leu Lys Ile Ser Leu Thr Tyr Ile Tyr Gly Ile

20 25 30Gly Ser Ala Arg Ser Asp Glu Ile Ile Lys Lys Leu Lys Leu Asp Pro

35 40 45Glu Ala Arg Ala Ser Glu Leu Thr Glu Glu Glu Val Gly Arg Leu Asn

50 55 60Ser Leu Leu Gln Ser Glu Tyr Thr Val Glu Gly Asp Leu Arg Arg Arg65 70 75 80Val Gln Ser Asp Ile Lys Arg Leu Ile Ala Ile His Ser Tyr Arg Gly

85 90 95Gln Arg His Arg Leu Ser Leu Pro Val Arg Gly Gln Arg Thr Lys Thr

100 105 110Asn Ser Arg Thr Arg Lys Gly Lys Arg Lys Thr Val Ala Gly Lys Lys

115 120 125Lys

<210>92

<211>202

<212>PRT

<213>衣原体属

<400>92Met His His His His His His Met Gly Ser Leu Val Gly Arg Gln Ala

5 10 15Pro Asp Phe Ser Gly Lys Ala Val Val Cys Gly Glu Glu Lys Glu Ile

20 25 30Ser Leu Ala Asp Phe Arg Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro

35 40 45Lys Asp Phe Thr Tyr Val Cys Pro Thr Glu Leu His Ala Phe Gln Asp

50 55 60Arg Leu Val Asp Phe Glu Glu His Gly Ala Val Val Leu Gly Cys Ser65 70 75 80Val Asp Asp Ile Glu Thr His Ser Arg Trp Leu Thr Val Ala Arg Asp

85 90 95Ala Gly Gly Ile Glu Gly Thr Glu Tyr Pro Leu Leu Ala Asp Pro Ser

100 105 110Phe Lys Ile Ser Glu Ala Phe Gly Val Leu Asn Pro Glu Gly Ser Leu

115 120 125Ala Leu Arg Ala Thr Phe Leu Ile Asp Lys His Gly Val Ile Arg His

130 135 140Ala Val Ile Asn Asp Leu Pro Leu Gly Arg Ser Ile Asp Glu Glu Leu145 150 155 160Arg Ile Leu Asp Ser Leu Ile Phe Phe Glu Asn His Gly Met Val Cys

165 170 175Pro Ala Asn Trp Arg Ser Gly Glu Arg Gly Met Val Pro Ser Glu Glu

180 185 190Gly Leu Lys Glu Tyr Phe Gln Thr Met Asp

195 200

<210>93

<211>19

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>93Glu Asn Ser Leu Gln Asp Pro Thr Asn Lys Arg Asn Ile Asn Pro Asp1 5 10 15Asp Lys Leu

<210>94

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>94Asp Pro Thr Asn Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys1 5 10 15Val Phe Gly Thr

20

<210>95

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>95Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys Val Phe Gly Thr1 5 10 15Glu Lys Pro Ile

20

<210>96

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>96Asp Asp Lys Leu Ala Lys Val Phe Gly Thr Glu Lys Pro Ile Asp Met1 5 10 15Phe Gln Met Thr

20

<210>97

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>97Lys Val Phe Gly Thr Glu Lys Pro Ile Asp Met Phe Gln Met Thr Lys1 5 10 15Met Val Ser Gln

20

<210>98

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>98Asn Lys Arg Asn Ile Asn Pro Asp Asp Lys Leu Ala Lys Val Phe Gly1 5 10 15Thr Glu Lys Pro

20

<210>99

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>99Asn Lys Arg Asn Ile Leu Pro Asp Ala Asn Leu Ala Lys Val Phe Gly1 5 10 15

<210>100

<211>15

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>100Lys Met Trp Asp Tyr Ile Lys Glu Asn Ser Leu Gln Asp Pro Thr1 5 10 15

<210>101

<211>20

<212>PRT

<213>Artificial Sequence

<220>

<223>Made in a lab

<400>101Thr Glu Ile Val Lys Lys Val Trp Glu Tyr Ile Lys Lys His Asn Cys1 5 10 15Gln Asp Gln Lys

20

<210>102

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>102Lys Val Trp Glu Tyr Ile Lys Lys His Asn Cys Gln Asp Gln Lys Asn1 5 10 15Lys Arg Asn Ile

20

<210>103

<211>15

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>103Lys Val Trp Glu Tyr Ile Lys Lys His Asn Cys Gln Asp Gln Lys1 5 10 15

<210>104

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>104Ala Glu Leu Thr Glu Glu Glu Val Gly Arg Leu Asn Ala Leu Leu Gln1 5 10 15Ser Asp Tyr Val

20

<210>105

<211>21

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>105Leu Gln Ser Asp Tyr Val Val Glu Gly Asp Leu Arg Arg Arg Val Gln1 5 10 15Ser Asp Ile Lys Arg

20

<210>106

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>106Met Pro Arg Ile Ile Gly Ile Asp Ile Pro Ala Lys Lys Lys Leu Lys1 5 10 15Ile Ser Leu Thr

20

<210>107

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>107Ala Glu Leu Thr Glu Glu Glu Val Gly Arg Leu Asn Ala Leu Leu Gln1 5 10 15Ser Asp Tyr Val

20

<210>108

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>108Leu Asn Ala Leu Leu Gln Ser Asp Tyr Val Val Glu Gly Asp Leu Arg1 5 10 15Arg Arg Val Gln

20

<210>109

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>109Leu Asn Ser Leu Leu Gln Ser Glu Tyr Thr Val Glu Gly Asp Leu Arg1 5 10 15Arg Arg Val Gln

20

<210>110

<211>1461

<212>DNA

<213>衣原体属

<400>110ctatctatga agttatgaat atggatctag aaacacgaag atcttttgcg gtacagcaag 60ggcactatca ggacccaaga gcttcagatt atgacctccc acgtgctagc gactatgatt 120tgcctagaag cccatatcct actccacctt tgccttctag atatcagcta cagaatatgg 180atgtagaagc agggttccgt gaggcagttt atgcttcttt tgtagcagga atgtacaatt 240atgtagtgac acagccgcaa gagcgtattc ccaatagtca gcaggtggaa gggattctgc 300gtgatatgct taccaacggg tcacagacat ttagcaacct gatgcagcgt tgggatagag 360aagtcgatag ggaataaact ggtatctacc ataggtttgt atcaaaaaac taagcccacc 420aagaagaaat tctctttggt gggcttcttt ttttattcaa aaaagaaagc cctcttcaag 480attatctcgt gccgctcgtg ccgaattcgg cacgagcggc acgaggagct gtaagtaagt 540attgccaaga gttggaagaa aaaatattag atttgtgtaa gcgtcatgcc gcaacaattt 600gctccattga ggaggatgct aaacaagaaa ttcgtcatca gacagaaagg tttaaacagc 660ggttgcaaca aaatcagaac acttgcagtc aattaacagc agagttgtgt aaattgagat 720ctgagaataa ggcattatcg gagcggctgc aggtgcaggc atcccgtcgt aaaaaataat 780taaagactcc tcagatattg catctgagag ttaggggttc cttttgctta cggcgcttta 840gttctgcatg ttgcggattt atagtgattt gcgagtaaag cgccgttctg atacagtttt 900tccgctttaa aaataaaaag gtggaaaaat gagtactact attagcggag acgcttcttc 960tttaccgttg ccaacagctt cctgcgtaga gacaaaatct acttcgtctt caacaaaagg 1020gaatacttgt tccaaaattt tggatatagc tttagctatc gtaggcgctt tagttgttgt 1080cgctggggta ttagctttgg ttttgtgcgc tagcaatgtc atatttactg taataggtat 1140tcctgcatta attattggat ctgcttgtgt gggtgcggga atatctcgtc ttatgtatcg 1200atcctcttat gctagcttag aagcaaaaaa tgttttggct gagcaacgtt tgcgtaatct 1260ttcagaagag aaggacgctt tggcctccgt ctctttcatt aataagatgt ttctgcgagg 1320tcttacggac gatctccaag ctttggaagc taaggtaatg gaatttgaga ttgattgttt 1380ggacagatta gagaaaaatg agcaagcttt attgtccgat gtgcgcttag ttttatctag 1440ctacacaaga tggttggata g 1461

<210>111

<211>267

<212>DNA

<213>衣原体属

<400>111gtcctcttct tattatagca gaagacattg aaggcgaagc tttagctact ttggtcgtga 60acagaattcg tggaggattc cgggtttgcg cagttaaagc tccaggcttt ggagatagaa 120gaaaagctat gttggaagac atcgctatct taactggcgg tcaactcatt agcgaagagt 180tgggcatgaa attagaaaac gctaacttag ctatgttagg taaagctaaa aaagttatcg 240tttctaaaga agacacgacc atcgtcg 267

<210>112

<211>698

<212>DNA

<213>衣原体属

<400>112tgataagcaa gcaaccgctc aactagcagc tctaactatt aaaaaaatcc tctgttttga 60tgaaaattcc tacgagaagg agctggcatg cttagaaaag aaacgcagta gcgtacaaaa 120agatctgagc caactgaaaa aatacacagt tctctacatc aagaagctgc tcgaaaccta 180cagacaactc gggcatcgaa agacaaaaat tgcaaaattt gatgacctac ctaccgagag 240agtctccgct cataagaaag caaaagaact cgctgcgctc gatcaagaag agaacttcta 300aaacgtgact cggcccttga gatccttaaa ctctcgggcc aaaaagacta cagtcttctc 360gagaagaaaa acggtgttag aaaatacgcg cgctaagact ttctctaaca atgactcaaa 420aagctgtaaa cgtatacgtt taccgctctt ccataatttc taggctgact ttcacattat 480ctcgacttgc tacggaaacc aataaagtac ggatagcctt aatagtgcgt ccttctttac 540cgataatttt accgatatct cccttagcaa cagtcaattc gtagataatc gtattggttc 600cctgcacctc tttcagatgc acttcctctg gcttatcaac aagatttttt acaatgtacg 660ctaaaaactc tttcatgcga agcaaatcct acacaagc 698

<210>113

<211>1142

<212>DNA

<213>衣原体属

<400>113ctcttcaaag attgtgagtt tatgtgaagg cgctgtcgct gatgcaagaa tgtgcaaagc 60agagttgata aaaaaagaag cggatgctta tttgttttgt gagaaaagcg ggatatatct 120aacgaaaaaa gaaggtattt tgattccttc tgcagggatt gatgaatcga atacggacca 180gccttttgtt ttatatccta aagatatttt gggatcgtgt aatcgcatcg gagaatggtt 240aagaaattat tttcgagtga aagagctagg cgtaatcatt acagatagcc atactactcc 300aatgcggcgt ggagtactgg gtatcgggct gtgttggtat ggattttctc cattacacaa 360ctatatagga tcgctagatt gtttcggtcg tcccttacag atgacgcaaa gtaatcttgt 420agatgcctta gcagttgcgg ctgttgtttg tatgggagag gggaatgagc aaacaccgtt 480agcggtgata gagcaggcac ctaatatggt ctaccattca tatcctactt ctcgagaaga 540gtattgttct ttgcgcatag atgaaacaga ggacttatac ggaccttttt tgcaagcggt 600tacgtggagt caagaaaaga aatgatggag gtgtttatga attttttaga tcagttagat 660ttaattattc aaaataagca tatgctagaa cacacgtttt atgtgaaatg gtcgaagggg 720gagcttacta aagagcaatt acaggcgtat gccaaagact attatttaca tatcaaagcc 780tttcctaaat atttatctgc gattcatagt cgttgcgatg atttagaggc gcgtaagtta 840ttgttagata acttgatgga tgaagagaac ggttacccta atcatattga tttgtggaag 900cagtttgtgt ttgctctagg agttactcca gaagagttag aggctcatga gcctagtgaa 960gcagcaaaag cgaaagtagc tactttcatg cggtggtgta caggagattc tttagctgca 1020ggagtggctg ctttgtattc ttatgagagt caaattccac gtatcgctag agagaaaatt 1080cgtggattga ctgagtactt tggattttcc aatcctgaag actatgcata tttcacagaa 1140ca 1142

<210>114

<211>976

<212>DNA

<213>衣原体属

<400>114aggtggatgg ggcgcctgtc caagatgtgc tcgctactct atatggaagc aatcacaaag 60ggactgcagc tgaagagtcg gctgctttaa gaacactatt ttctcgcatg gcctctttag 120ggcacaaagt accttctggg cgcactactt taaagattcg tcgtcctttt ggtactacga 180gagaagttcg tgtgaaatgg cgttatgttc ctgaaggtgt aggagatttg gctaccatag 240ctccttctat cagggctcca cagttacaga aatcgatgag aagctttttc cctaagaaag 300atgatgcgtt tcatcggtct agttcgctat tctactctcc aatggttccg catttttggg 360cagagcttcg caatcattat gcaacgagtg gtttgaaaag cgggtacaat attgggagta 420ccgatgggtt tctccctgtc attgggcctg ttatatggga gtcggagggt cttttccgcg 480cttatatttc ttcggtgact gatggggatg gtaagagcca taaagtagga tttctaagaa 540ttcctacata tagttggcag gacatggaag attttgatcc ttcaggaccg cctccttggg 600aagaatttgc taagattatt caagtatttt cttctaatac agaagctttg attatcgacc 660aaacgaacaa cccaggtggt agtgtccttt atctttatgc actgctttcc atgttgacag 720accgtccttt agaacttcct aaacatagaa tgattctgac tcaggatgaa gtggttgatg 780ctttagattg gttaaccctg ttggaaaacg tagacacaaa cgtggagtct cgccttgctc 840tgggagacaa catggaagga tatactgtgg atctacaggt tgccgagtat ttaaaaagct 900ttggacgtca agtattgaat tgttggagta aaggggatat cgagttatca acacctattc 960ctctttttgg ttttga 976

<210>115

<211>995

<212>DNA

<213>衣原体属

<400>115ttatcctaga aatttggtgt tcaatatgag cgaaaaaaga aagtctaaca aaattattgg 60tatcgaccta gggacgacca actcttgcgt ctctgttatg gaaggtggcc aacctaaagt 120tattgcctct tctgaaggaa ctcgtactac tccttctatc gttgctttta aaggtggcga 180aactcttgtt ggaattcctg caaaacgtca ggcagtaacc aatcctgaaa aaacattggc 240ttctactaag cgattcatcg gtagaaaatt ctctgaagtc gaatctgaaa ttaaaacagt 300cccctacaaa gttgctccta actcgaaagg agatgcggtc tttgatgtgg aacaaaaact 360gtacactcca gaagaaatcg gcgctcagat cctcatgaag atgaaggaaa ctgctgaggc 420ttatctcgga gaaacagtaa cggaagcagt cattaccgta ccagcttact ttaacgattc 480tcaaagagct tctacaaaag atgctggacg tatcgcagga ttagatgtta aacgcattat 540tcctgaacca acagcggccg ctcttgctta tggtattgat aaggaaggag ataaaaaaat 600cgccgtcttc gacttaggag gaggaacttt cgatatttct atcttggaaa tcggtgacgg 660agtttttgaa gttctctcaa ccaacgggga tactcacttg ggaggagacg acttcgacgg 720agtcatcatc aactggatgc ttgatgaatt caaaaaacaa gaaggcattg atctaagcaa 780agataacatg gctttgcaaa gattgaaaga tgctgctgaa aaagcaaaaa tagaattgtc 840tggtgtatcg tctactgaaa tcaatcagcc attcatcact atcgacgcta atggacctaa 900acatttggct ttaactctaa ctcgcgctca attcgaacac ctagcttcct ctctcattga 960gcgaaccaaa caaccttgtg ctcaggcttt aaaag 995

<210>116

<211>437

<212>DNA

<213>衣原体属

<400>116gtcacagcta aaggcggtgg gctttatact gataagaatc tttcgattac taacatcaca 60ggaattatcg aaattgcaaa taacaaagcg acagatgttg gaggtggtgc ttacgtaaaa 120ggaaccctta cttgtaaaaa ctctcaccgt ctacaatttt tgaaaaactc ttccgataaa 180caaggtggag gaatctacgg agaagacaac atcaccctat ctaatttgac agggaagact 240ctattccaag agaatactgc caaaaaagag ggcggtggac tcttcataaa aggtacagat 300aaagctctta caatgacagg actggatagt ttctgtttaa ttaataacac atcagaaaaa 360catggtggtg gagcctttgt taccaaagaa atctctcaga cttacacctc tgatgtggaa 420acaattccag gaatcac 437

<210>117

<211>446

<212>DNA

<213>衣原体属

<400>117aagtttacct agaccaaact gaagatgacg aaggaaaagt tgttttatcc agagaaaaag 60caacaagaca acgacaatgg gaatacattc ttgctcactg cgaggaaggt tctattgtta 120agggacaaat tacccgaaaa gttaagggtg gtttgatcgt agatattggt atggaagcct 180tccttccagg atcccaaata gacaataaga agatcaagaa cttagatgat tacgtaggca 240aggtttgtga gttcaaaatt ctcaaaatca acgtggatcg tcggaacgtt gttgtatcta 300gaagagaact tctcgaagct gaacgcattt ctaagaaagc agagttgatc gagcaaatca 360ctatcggtga acgtcgcaaa ggtatcgtta agaatatcac agatttcgga gtattcttgg 420atcttgatgg cattgacggc ctactc 446

<210>118

<211>951

<212>DNA

<213>衣原体属

<400>118agtattgcga aatattactg tgagaagcaa tgctgagagc ggttctagta aaagtgaggg 60gagagctgtc agaagggatc gctcaggaag cgagacaacg tgtggctgat ttattaggaa 120gattccctct ttatcctgaa atcgatctgg aaacgctagt ttagtgggag actctatgcc 180tgaaggggaa atgatgcata agttgcaaga tgtcatagat agaaagttgt tggattctcg 240tcgtattttc ttctccgaac ctgtaacgga gaaaagtgct gcagaagcca tcaaaaagct 300ttggtatttg gaactcacca atcctgggca gccaattgta tttgtcatta atagccctgg 360agggtctgtt gatgctgggt ttgctgtttg ggaccaaatt aaaatgatct cttctccttt 420gactacagtt gttacaggtt tagcagcatc tatgggatct gtattgagtt tgtgtgctgt 480tccaggaaga cgttttgcta cgcctcatgc gcgcattatg attcaccagc cttctattgg 540aggaaccatt actggtcaag ccacggactt ggatattcat gctcgtgaaa ttttaaaaac 600aaaagcacgc attattgatg tgtatgtcga ggcaactgga caatctccag aggtgataga 660gaaagctatc gatcgagata tgtggatgag tgcaaatgaa gcaatggagt ttggactgtt 720agatgggatt ctcttctctt ttaacgactt gtagatatct tttatattct ggagcaggaa 780acagtttcat tttgggagaa tcgatgcctt ctcttgagga tgttctgttt ttatgccagg 840aagagatggt tgatgggttt ttatgtgtag agtcttctga aatagcagat gctaaactca 900ctgtttttaa tagtgatgga tctatcgcgt ctatgtgcgg gaatgggttg c 951

<210>119

<211>953

<212>DNA

<213>衣原体属

<400>119atatcaaagt tgggcaaatg acagagccgc tcaaggacca gcaaataatc cttgggacaa 60catcaacacc tgtcgcagcc aaaatgacag cttctgatgg aatatcttta acagtctcca 120ataatccatc aaccaatgct tctattacaa ttggtttgga tgcggaaaaa gcttaccagc 180ttattctaga aaagttggga gatcaaattc ttggtggaat tgctgatact attgttgata 240gtacagtcca agatatttta gacaaaatca caacagaccc ttctctaggt ttgttgaaag 300cttttaacaa ctttccaatc actaataaaa ttcaatgcaa cgggttattc actcccagga 360acattgaaac tttattagga ggaactgaaa taggaaaatt cacagtcaca cccaaaagct 420ctgggagcat gttcttagtc tcagcagata ttattgcatc aagaatggaa ggcggcgttg 480ttctagcttt ggtacgagaa ggtgattcta agccctacgc gattagttat ggatactcat 540caggcgttcc taatttatgt agtctaagaa ccagaattat taatacagga ttgactccga 600caacgtattc attacgtgta ggcggtttag aaagcggtgt ggtatgggtt aatgcccttt 660ctaatggcaa tgatatttta ggaataacaa atacttctaa tgtatctttt ttggaggtaa 720tacctcaaac aaacgcttaa acaattttta ttggattttt cttataggtt ttatatttag 780agaaaaaagt tcgaattacg gggtttgtta tgcaaaataa aagcaaagtg agggacgatt 840ttattaaaat tgttaaagat tcctggtatc ggtctgcgat tccgactcgt ccaacatcaa 900tacaacctat taatttcccc tcgtcaaaaa taaggttatc aagtgagaaa tca 953

<210>120

<211>897

<212>DNA

<21 3>衣原体属

<220>

<221>misc_feature

<222>395

<223>n＝A，T，C或G

<400>120atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca gcaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120gttaaggtcg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttctcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctcttacat gaaagctgct agtcagaaac cgcaagaagg ggatgagggg 360ctcgtagcag atctttgtgt gtctcataag cgcanagcgg ctgcggctgt ctgtagcttc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg cgcaaccgtt tctttcttcc caaattaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tttgtggtgg gttctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgtcactc 660gaattgtcgg gagaggaaaa tgcttgcgag aggagagtcg ctggagagaa agcGaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gttgcctatt acaatgggta ttcgtgcaat tgtggctgcg 840ggatgtacgt tcacttctgc agttattgga ttgtggactt tctgcgccag agcataa 897

<210>121

<211>298

<212>PRT

<213>衣原体属

<400>121Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

50 55 60Ala His Ile Thr Ala Ser Gln Val Ser Lys Gly Leu Gly Asp Ala Arg65 70 75 80Thr Val Leu Ala Leu Gly Asn Ala Phe Asn Gly Ala Leu Pro Gly Thr

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser Tyr Met Lys Ala Ala Ser Gln

100 105 110Lys Pro Gln Glu Gly Asp Glu Gly Leu Val Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Phe Ile Gly Gly Ile

130 135 140Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160Lys Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Ile Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Phe Val

180 185 190Val Gly Ser Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Ser Leu Glu Leu Ser Gly

210 215 220Glu Glu Asn Ala Cys Glu Arg Arg Val Ala Gly Glu Lys Ala Lys Thr225 230 235 240Phe Thr Arg Ile Lys Tyr Ala Leu Leu Thr Met Leu Glu Lys Phe Leu

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Val

275 280 285Ile Gly Leu Trp Thr Phe Cys Ala Arg Ala

290 295

<210>122

<211>897

<212>DNA

<213>衣原体属

<400>122atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca gcaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120gttaaggtcg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatacgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtggcttc 420atcggaggaa ttacctacct cgcgacattc ggagttatcc gtccgattct gtttgtcaac 480aaaatgctgg tgaacccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgtcgg gagaggaaaa tgcttgcgag aagagagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>123

<211>298

<212>PRT

<213>衣原体属

<400>123Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

50 55 60Ala His Ile Thr Ala Ser Gln Val Ser Lys Gly Leu Gly Asp Thr Arg65 70 75 80Thr Val Val Ala Leu Gly Asn Ala Phe Asn Gly Ala Leu Pro Gly Thr

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Gly Phe Ile Gly Gly Ile

130 135 140Thr Tyr Leu Ala Thr Phe Gly Val Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160LVs Met Leu Val Asn Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Ser Gly

210 215 220Glu Glu Asn Ala Cys Glu Lys Arg Val Ala Gly Glu Lys Ala Lys Thr225 230 235 240Phe Thr Arg Ile Lys Tyr Ala Leu Leu Thr Met Leu Glu Lys Phe Leu

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>124

<211>897

<212>DNA

<213>衣原体属

<400>124atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>125

<211>298

<212>PRT

<213>衣原体属

<400>125Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Pro Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>126

<211>897

<212>DNA

<213>衣原体属

<400>126atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>127

<211>298

<212>PRT

<213>衣原体属

<400>127Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Pro Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>128

<211>897

<212>DNA

<213>衣原体属

<400>128atggcttcta tatgtggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca gcaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120gttaaggtcg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatacgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtggcttc 420atcggaggaa ttacctacct cgcgacattc ggagttatcc gtccgattct gtttgtcaac 480aaaatgctgg tgaacccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgtcgg gagaggaaaa tgcttgcgag aagagagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>129

<211>298

<212>PRT

<213>衣原体属

<400>129Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

50 55 60Ala His Ile Thr Ala Ser Gln Val Ser Lys Gly Leu Gly Asp Thr Arg65 70 75 80Thr Val Val Ala Leu Gly Asn Ala Phe Asn Gly Ala Leu Pro GlV Thr

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Gly Phe Ile Gly Gly Ile

130 135 140Thr Tyr Leu Ala Thr Phe Gly Val Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160Lys Met Leu Val Asn Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Ser Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>130

<211>897

<212>DNA

<213>衣原体属

<400>130atggctgcta tatgtggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca gcaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120gttaaggtcg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttctcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctcttacat gaaagctgct agtcagaaac cgcaagaagg ggatgagggg 360ctcgtagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcttc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg cgcaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tttgtggtgg gttctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgtcactc 660gaattgtcgg gagaggaaaa tgcttgcgag aggggagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gttgcctatt acaatgggta ttcgtgcaat tgtggctgcg 840ggatgtacgt tcacttctgc agttattgga ttgtggactt tctgcaacag agtataa 897

<210>131

<211>298

<212>PRT

<213>衣原体属

<400>131Met Ala Ala Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser Tyr Met Lys Ala Ala Ser Gln

100 105 110Lys Pro Gln Glu Gly Asp Glu Gly Leu Val Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Phe Ile Gly Gly Ile130 135 140Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160Lys Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Phe Val

180 185 190Val Gly Ser Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Ser Leu Glu Leu Ser Gly

210 215 220Glu Glu Asn Ala Cys Glu Arg Gly Val Ala Gly Glu Lys Ala Lys Thr225 230 235 240Phe Thr Arg Ile Lys Tyr Ala Leu Leu Thr Met Leu Glu Lys Phe Leu

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Val

275 280 285Ile Gly Leu Trp Thr Phe Cys Asn Arg Val

290 295

<210>132

<211>897

<212>DNA

<213>衣原体属

<400>132atggctgcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca gcaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120gttaaggtcg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttctcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctcttacat gaaagctgct agtcagaaac cgcaagaagg ggatgagggg 360ctcgtagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcttc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg cgcaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tttgtggtgg gttctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgtcactc 660gaattgtcgg gagaggaaaa tgcttgtgag aggagagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gttgcctatt acaatgggta ttcgtgcaat tgtggctgcg 840ggatgtacgt tcacttctgc agttattgga ttgtggactt tctgcaacag agtataa 897

<210>133

<211>298

<212>PRT

<213>衣原体属

<400>133Met Ala Ala Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser Tyr Met Lys Ala Ala Ser Gln

100 105 110Lys Pro Gln Glu Gly Asp Glu Gly Leu Val Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Phe Ile Gly Gly Ile

130 135 140Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile Leu Phe Val Asn145 150 155 160Lys Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Phe Val

180 185 190Val Gly Ser Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Ser Leu Glu Leu Ser Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Val

275 280 285Ile Gly Leu Trp Thr Phe Cys Asn Arg Val

290 295

<210>134

<211>897

<212>DNA

<213>衣原体属

<400>134atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcggaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaaatgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>135

<211>298

<212>PRT

<213>衣原体属

<400>135Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Glu Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Lau Leu Glu Met Pro Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>136

<211>882

<212>DNA

<213>衣原体属

<400>136atggcttctg tatgtgggcg attaagtgct ggggtgggga acagatttaa cgcatttttc 60acgcgtcccg gtaacaagct atcacggttt gtaaatagcg caaaaggatt agacagatca 120ataaaggttg ggaagtctgc tgctgaatta acggcgagta ttttagagca aactgggggg 180gcagggactg atgcacatgt tacggcggcc aaggtgtcta aagcacttgg ggacgcgcga 240acagtaatgg ctctagggaa tgtcttcaat gggtctgtgc cagcaaccat tcaaagtgcg 300cgaagctgtc tcgcccattt acgagcggcc ggcaaagaag aagaaacatg ctccaaggtg 360aaagatctct gtgtttctca tagacgaaga gctgcggctg aggcttgtaa tgttattgga 420ggagcaactt atattacaac tttcggagcg attcgtccga cattactcgt taacaagctt 480cttgccaaac cattcctttc ctcccaagcc aaagaagggt tgggagcttc tgttggttat 540atcatggcag cgaaccatgc ggcatctgtg cttgggtctg ctttaagtat tagcgcagaa 600agagcagact gtgaagagcg gtgtgatcgc attcgatgta gtgaggatgg tgaaatttgc 660gaaggcaata aattaacagc tatttcggaa gagaaggcta gatcatggac tctcattaag 720tacagattcc ttactatgat agaaaaacta tttgagatgg tggcggatat cttcaagtta 780attcctttgc caatttcgca tggaattcgt gctattgttg ctgcgggatg tacgttgact 840tctgcagtta ttggcttagg tactttttgg tctagagcat aa 882

<210>137

<211>293

<212>PRT

<213>衣原体属

<400>137Met Ala Ser Val Cys Gly Arg Leu Ser Ala Gly Val Gly Asn Arg Phe1 5 10 15Asn Ala Phe Phe Thr Arg Pro Gly Asn Lys Leu Ser Arg Phe Val Asn

20 25 30Ser Ala Lys Gly Leu Asp Arg Ser Ile Lys Val Gly Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Ser Ile Leu Glu Gln Thr Gly Gly Ala Gly Thr Asp

50 55 60Ala His Val Thr Ala Ala Lys Val Ser Lys Ala Leu Gly Asp Ala Arg65 70 75 80Thr Val Met Ala Leu Gly Asn Val Phe Asn Gly Ser Val Pro Ala Thr

85 90 95Ile Gln Ser Ala Arg Ser Cys Leu Ala His Leu Arg Ala Ala Gly Lys

100 105 110Glu Glu Glu Thr Cys Ser Lys Val Lys Asp Leu Cys Val Ser His Arg

115 120 125Arg Arg Ala Ala Ala Glu Ala Cys Asn Val Ile Gly Gly Ala Thr Tyr

130 135 140Ile Thr Thr Phe Gly Ala Ile Arg Pro Thr Leu Leu Val Asn Lys Leu145 150 155 160Leu Ala Lys Pro Phe Leu Ser Ser Gln Ala Lys Glu Gly Leu Gly Ala

165 170 175Ser Val Gly Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val Leu Gly

180 185 190Ser Ala Lau Ser Ile Ser Ala Glu Arg Ala Asp Cys Glu Glu Arg Cys

195 200 205Asp Arg Ile Arg Cys Ser Glu Asp Gly Glu Ile Cys Glu Gly Asn Lys

210 215 220Leu Thr Ala Ile Ser Glu Glu Lys Ala Arg Ser Trp Thr Leu Ile Lys225 230 235 240Tyr Arg Phe Leu Thr Met Ile Glu Lys Leu Phe Glu Met Val Ala Asp

245 250 255Ile Phe Lys Leu Ile Pro Leu Pro Ile Ser His Gly Ile Arg Ala Ile

260 265 270Val Ala Ala Gly Cys Thr Leu Thr Ser Ala Val Ile Gly Leu Gly Thr

275 280 285Phe Trp Ser Arg Ala

290

<210>138

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>138Asp Leu Cys Val Ser His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser1 5 10 15

<210>139

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>139Arg Ala Ala Ala Ala Val Cys Ser Phe Ile Gly Gly Ile Thr Tyr Leu1 5 10 15

<210>140

<211>18

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>140Cys Ser Phe Ile Gly Gly Ile Thr Tyr Leu Ala Thr Phe Gly Ala Ile1 5 10 15Arg Pro

<210>141

<211>18

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>141Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile Leu Phe Val Asn Lys1 5 10 15Met Leu

<210>142

<211>18

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>142Arg Pro Ile Leu Phe Val Asn Lys Met Leu Ala Gln Pro Phe Leu Ser1 5 10 15Ser Gln

<210>143

<211>17

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>143Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Thr Lys Ala Asn Met Gly1 5 10 15Ser

<210>144

<211>10

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>144Cys Ser Phe Ile Gly Gly Ile Thr Tyr Leu1 5 10

<210>145

<211>9

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>145Ser Phe Ile Gly Gly Ile Thr Tyr Leu1 5

<210>146

<211>8

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>146Phe Ile Gly Gly Ile Thr Tyr Leu1 5

<210>147

<211>9

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>147Cys Ser Phe Ile Gly GlyIle Thr Tyr1 5

<210>148

<211>8

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>148Cys Ser Phe Ile Gly Gly Ile Thr1 5

<210>149

<211>10

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>149Cys Ser Ile Ile Gly Gly Ile Thr Tyr Leu1 5 10

<210>150

<211>10

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>150Cys Gly Phe Ile Gly Gly Ile Thr Tyr Leu1 5 10

<210>151

<211>9

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>151Gly Phe Ile Gly Gly Ile Thr Tyr Leu 1 5

<210>152

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>152Gln Ile Phe Val Cys Leu Ile Ser Ala Glu Arg Leu Arg Leu Arg Leu1 5 10 15Ser Val Ala Ser

20

<210>153

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>153Glu Arg Leu Arg Leu Arg Leu Ser Val Ala Ser Ser Glu Glu Leu Pro1 5 10 15Thr Ser Arg His

20

<210>154

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>154Ala Ser Ser Glu Glu Leu Pro Thr Ser Arg His Ser Glu Leu Ser Val1 5 10 15Arg Phe Cys Leu

20

<210>155

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>155Arg His Ser Glu Leu Ser Val Arg Phe Cys Leu Ser Thr Lys Cys Trp1 5 10 15Arg Asn Arg Phe

20

<210>156

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>156Leu Ser Thr Lys Cys Trp Arg Asn Arg Phe Phe Leu Pro Lys Leu Lys1 5 10 15Gln Ile Trp Asp

20

<210>157

<211>53

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>157Ile Phe Val Cys Leu Ile Ser Ala Glu Arg Leu Arg Leu Ser Val Ala1 5 10 15Ser Ser Glu Glu Leu Pro Thr Ser Arg His Ser Glu Leu Ser Val Arg

20 25 30Phe Cys Leu Ser Thr Lys Cys Trp Arg Asn Arg Phe Phe Leu Pro Lys

35 40 45Leu Lys Gln Ile Trp

50

<210>158

<211>52

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>158Leu Cys Val Ser His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Phe1 5 10 15Ile Gly Gly Ile Thr Tyr Leu Ala Thr Phe Gly Ala Ile Arg Pro Ile

20 25 30Leu Phe Val Asn Lys Met Leu Ala Gln Pro Phe Leu Ser Ser Gln Ile

35 40 45Lys Ala Asn Met

50

<210>159

<211>24

<212>DNA

<213>衣原体属

<400>159ttttgaagca ggtaggtgaa tatg 24

<210>160

<211>24

<212>DNA

<213>衣原体属

<400>160ttaagaaatt taaaaaatcc ctta 24

<210>161

<211>24

<212>DNA

<213>衣原体属

<400>161ggtataatat ctctctaaat tttg 24

<210>162

<211>19

<212>DNA

<213>衣原体属

<400>162agataaaaaa ggctgtttc 19

<210>163

<211>24

<212>DNA

<213>衣原体属

<400>163ttttgaagca ggtaggtgaa tatg 24

<210>164

<211>29

<212>DNA

<213>衣原体属

<400>164tttacaataa gaaaagctaa gcactttgt 29

<210>165

<211>20

<212>DNA

<213>衣原体属

<400>165ccttacacag tcctgctgac 20

<210>166

<211>20

<212>DNA

<213>衣原体属

<400>166gtttccgggc cctcacattg 20

<210>167

<211>9

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>167Ser Phe Ile Gly Gly Ile Thr Tyr Leu1 5

<210>168

<211>9

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>168Ser Ile Ile Gly Gly Ile Thr Tyr Leu1 5

<210>169

<211>2643

<212>DNA

<213>衣原体属

<400>169gcaatcatgc gacctgatca tatgaacttc tgttgtctat gtgctgctat tttgtcatcc 60acagcggtcc tctttggcca ggatccctta ggtgaaaccg ccctcctcac taaaaatcct 120aatcatgtcg tctgtacatt ttttgaggac tgtaccatgg agagcctctt tcctgctctt 180tgtgctcatg catcacaaga cgatcctttg tatgtacttg gaaattccta ctgttggttc 240gtatctaaac tccatatcac ggaccccaaa gaggctcttt ttaaagaaaa aggagatctt 300tccattcaaa actttcgctt cctttccttc acagattgct cttccaagga aagctctcct 360tctattattc atcaaaagaa tggtcagtta tccttgcgca ataatggtag catgagtttc 420tgtcgaaatc atgctgaagg ctctggagga gccatctctg cggatgcctt ttctctacag 480cacaactatc ttttcacagc ttttgaagag aattcttcta aaggaaatgg cggagccatt 540caggctcaaa ccttctcttt atctagaaat gtgtcgccta tttctttcgc ccgtaatcgt 600gcggatttaa atggcggcgc tatttgctgt agtaatctta tttgttcagg gaatgtaaac 660cctctctttt tcactggaaa ctccgccacg aatggaggcg ctatttgttg tatcagcgat 720ctaaacacct cagaaaaagg ctctctctct cttgcttgta accaagaaac gctatttgca 780agcaattctg ctaaagaaaa aggcggggct atttatgcca agcacatggt attgcgttat 840aacggtcctg tttccttcat taacaacagc gctaaaatag gtggagctat cgccatccag 900tccggaggga gtctctctat ccttgcaggt gaaggatctg ttctgttcca gaataactcc 960caacgcacct ccgaccaagg tctagtaaga aacgccatct acttaragaa agatgcgatt 1020ctttcttcct tagaagctcg caacggagat attcttttct ttgatcctat tgtacaagaa 1080agtagcagca aagaatcgcc tcttccctcc tctttgcaag ccagcgtgac ttctcccacc 1140ccagccaccg catctccttt agttattcag acaagtgcaa accgttcagt gattttctcg 1200agcgaacgtc tttctgaaga agaaaaaact cctgataacc tcacttccca actacagcag 1260cctatcgaac tgaaatccgg acgcttagtt ttaaaagatc gcgctgtcct ttccgcgcct 1320tctctctctc aggatcctca agctctcctc attatggaag cgggaacttc tttaaaaact 1380tcctctgatt tgaagttagc tacgctaagt attccccttc attccttaga tactgaaaaa 1440agcgtaacta tccacgcccc taatctttct atccaaaaga tcttcctctc taactctgga 1500gatgagaatt tttatgaaaa tgtagagctt ctcagtaaag agcaaaacaa tattcctctc 1560cttactctcc ctaaagagca atctcattta catcttcctg atgggaacct ctcttctcac 1620tttggatatc aaggagattg gactttttct tggaaagatt ctgatgaagg gcattctctg 1680attgctaatt ggacgcctaa aaactatgtg cctcatccag aacgtcaatc tacactcgtt 1740gcgaacactc tttggaacac ctattccgat atgcaagctg tgcagtcgat gattaataca 1800acagcgcacg gaggagccta tctatttgga acgtggggat ctgctgtttc taatttattc 1860tatgttcacg acagctctgg gaaacctatc gataattggc atcatagaag ccttggctac 1920ctattcggta tcagtactca cagtttagat gaccattctt tctgcttggc tgcaggacaa 1980ttactcggga aatcgtccga ttcctttatt acgtctacag aaacgacctc ctatatagct 2040actgtacaag cgcaactcgc tacctctcta atgaaaatct ctgcacaggc atgctacaat 2100gaaagtatcc atgagctaaa aacaaaatat cgctccttct ctaaagaagg attcggatcc 2160tggcatagcg ttgcagtatc cggagaagtg tgcgcatcga ttcctattgt atccaatggt 2220tccggactgt tcagctcctt ctctattttc tctaaactgc aaggattttc aggaacacag 2280gacggttttg aggagagttc gggagagatt cggtcctttt ctgccagctc tttcagaaat 2340atttcacttc ctataggaat aacatttgaa aaaaaatccc aaaaaacacg aacctactat 2400tactttctag gagcctacat ccaagacctg aaacgtgatg tggaatcggg acctgtagtg 2460ttactcaaaa atgccgtctc ctgggatgct cctatggcga acttggattc acgagcctac 2520atgttccggc ttacgaatca aagagctcta cacagacttc agacgctgtt aaatgtgtct 2580tgtgtgctgc gtgggcaaag ccatagttac tccctggatc tggggaccac ttacaggttc 2640tag 2643

<210>170

<211>2949

<212>DNA

<213>衣原体属

<400>170atgattcctc aaggaattta cgatggggag acgttaactg tatcatttcc ctatactgtt 60ataggagatc cgagtgggac tactgttttt tctgcaggag agttaacatt aaaaaatctt 120gacaattcta ttgcagcttt gcctttaagt tgttttggga acttattagg gagttttact 180gttttaggga gaggacactc gttgactttc gagaacatac ggacttctac aaatggggca 240gctctaagta atagcgctgc tgatggactg tttactattg agggttttaa agaattatcc 300ttttccaatt gcaattcatt acttgccgta ctgcctgctg caacgactaa taagggtagc 360cagactccga cgacaacatc tacaccgtct aatggtacta tttattctaa aacagatctt 420ttgttactca ataatgagaa gttctcattc tatagtaatt tagtctctgg agatggggga 480gctatagatg ctaagagctt aacggttcaa ggaattagca agctttgtgt cttccaagaa 540aatactgctc aagctgatgg gggagcttgt caagtagtca ccagtttctc tgctatggct 600aacgaggctc ctattgcctt tgtagcgaat gttgcaggag taagaggggg agggattgct 660gctgttcagg atgggcagca gggagtgtca tcatctactt caacagaaga tccagtagta 720agtttttcca gaaatactgc ggtagagttt gatgggaacg tagcccgagt aggaggaggg 780atttactcct acgggaacgt tgctttcctg aataatggaa aaaccttgtt tctcaacaat 840gttgcttctc ctgtttacat tgctgctaag caaccaacaa gtggacaggc ttctaatacg 900agtaataatt acggagatgg aggagctatc ttctgtaaga atggtgcgca agcaggatcc 960aataactctg gatcagtttc ctttgatgga gagggagtag ttttctttag tagcaatgta 1020gctgctggga aagggggagc tatttatgcc aaaaagctct cggttgctaa ctgtggccct 1080gtacaatttt taaggaatat cgctaatgat ggtggagcga tttatttagg agaatctgga 1140gagctcagtt tatctgctga ttatggagat attattttcg atgggaatct taaaagaaca 1200gccaaagaga atgctgccga tgttaatggc gtaactgtgt cctcacaagc catttcgatg 1260ggatcgggag ggaaaataac gacattaaga gctaaagcag ggcatcagat tctctttaat 1320gatcccatcg agatggcaaa cggaaataac cagccagcgc agtcttccaa acttctaaaa 1380attaacgatg gtgaaggata cacaggggat attgtttttg ctaatggaag cagtactttg 1440taccaaaatg ttacgataga gcaaggaagg attgttcttc gtgaaaaggc aaaattatca 1500gtgaattctc taagtcagac aggtgggagt ctgtatatgg aagctgggag tacattggat 1560tttgtaactc cacaaccacc acaacagcct cctgccgcta atcagttgat cacgctttcc 1620aatctgcatt tgtctctttc ttctttgtta gcaaacaatg cagttacgaa tcctcctacc 1680aatcctccag cgcaagattc tcatcctgca gtcattggta gcacaactgc tggttctgtt 1740acaattagtg ggcctatctt ttttgaggat ttggatgata cagcttatga taggtatgat 1800tggctaggtt ctaatcaaaa aatcaatgtc ctgaaattac agttagggac taagccccca 1860gctaatgccc catcagattt gactctaggg aatgagatgc ctaagtatgg ctatcaagga 1920agctggaagc ttgcgtggga tcctaataca gcaaataatg gtccttatac tctgaaagct 1980acatggacta aaactgggta taatcctggg cctgagcgag tagcttcttt ggttccaaat 2040agtttatggg gatccatttt agatatacga tctgcgcatt cagcaattca agcaagtgtg 2100gatgggcgct cttattgtcg aggattatgg gtttctggag tttcgaattt cttctatcat 2160gaccgcgatg ctttaggtca gggatatcgg tatattagtg ggggttattc cttaggagca 2220aactcctact ttggatcatc gatgtttggt ctagcattta ccgaagtatt tggtagatct 2280aaagattatg tagtgtgtcg ttccaatcat catgcttgca taggatccgt ttatctatct 2340acccaacaag ctttatgtgg atcctatttg ttcggagatg cgtttatccg tgctagctac 2400gggtttggga atcagcatat gaaaacctca tatacatttg cagaggagag cgatgttcgt 2460tgggataata actgtctggc tggagagatt ggagcgggat taccgattgt gattactcca 2520tctaagctct atttgaatga gttgcgtcct ttcgtgcaag ctgagttttc ttatgccgat 2580catgaatctt ttacagagga aggcgatcaa gctcgggcat tcaagagcgg acatctccta 2640aatctatcag ttcctgttgg agtgaagttt gatcgatgtt ctagtacaca tcctaataaa 2700tatagcttta tggcggctta tatctgtgat gcttatcgca ccatctctgg tactgagaca 2760acgctcctat cccatcaaga gacatggaca acagatgcct ttcatttagc aagacatgga 2820gttgtggtta gaggatctat gtatgcttct ctaacaagta atatagaagt atatggccat 2880ggaagatatg agtatcgaga tgcttctcga ggctatggtt tgagtgcagg magtaaagtc 2940yggttctaa 2949

<210>171

<211>2895

<212>DNA

<213>衣原体属

<400>171atgaaaaaag cgtttttctt tttccttatc ggaaactccc tatcaggact agctagagag 60gttccttcta gaatctttct tatgcccaac tcagttccag atcctacgaa agagtcgcta 120tcaaataaaa ttagtttgac aggagacact cacaatctca ctaactgcta tctcgataac 180ctacgctaca tactggctat tctacaaaaa actcccaatg aaggagctgc tgtcacaata 240acagattacc taagcttttt tgatacacaa aaagaaggta tttattttgc aaaaaatctc 300acccctgaaa gtggtggtgc gattggttat gcgagtccca attctcctac cgtggagatt 360cgtgatacaa taggtcctgt aatctttgaa aataatactt gttgcagact atttacatgg 420agaaatcctt atgctgctga taaaataaga gaaggcggag ccattcatgc tcaaaatctt 480tacataaatc ataatcatga tgtggtcgga tttatgaaga acttttctta tgtccaagga 540ggagccatta gtaccgctaa tacctttgtt gtgagcgaga atcagtcttg ttttctcttt 600atggacaaca tctgtattca aactaataca gcaggaaaag gtggcgctat ctatgctgga 660acgagcaatt cttttgagag taataactgc gatctcttct tcatcaataa cgcctgttgt 720gcaggaggag cgatcttctc ccctatctgt tctctaacag gaaatcgtgg taacatcgtt 780ttctataaca atcgctgctt taaaaatgta gaaacagctt cttcagaagc ttctgatgga 840ggagcaatta aagtaactac tcgcctagat gttacaggca atcgtggtag gatctttttt 900agtgacaata tcacaaaaaa ttatggcgga gctatttacg ctcctgtagt taccctagtg 960gataatggcc ctacctactt tataaacaat atcgccaata ataagggggg cgctatctat 1020atagacggaa ccagtaactc caaaatttct gccgaccgcc atgctattat ttttaatgaa 1080aatattgtga ctaatgtaac taatgcaaat ggtaccagta cgtcagctaa tcctcctaga 1140agaaatgcaa taacagtagc aagctcctct ggtgaaattc tattaggagc agggagtagc 1200caaaatttaa ttttttatga tcctattgaa gttagcaatg caggggtctc tgtgtccttc 1260aataaggaag ctgatcaaac aggctctgta gtattttcag gagctactgt taattctgca 1320gattttcatc aacgcaattt acaaacaaaa acacctgcac cccttactct cagtaatggt 1380tttctatgta tcgaagatca tgctcagctt acagtgaatc gattcacaca aactgggggt 1440gttgtttctc ttgggaatgg agcagttctg agttgctata aaaatggtac aggagattct 1500gctagcaatg cctctataac actgaagcat attggattga atctttcttc cattctgaaa 1560agtggtgctg agattccttt attgtgggta gagcctacaa ataacagcaa taactataca 1620gcagatactg cagctacctt ttcattaagt gatgtaaaac tctcactcat tgatgactac 1680gggaactctc cttatgaatc cacagatctg acccatgctc tgtcatcaca gcctatgcta 1740tctatttctg aagctagcga taaccagcta caatcagaaa atatagattt ttcgggacta 1800aatgtccctc attatggatg gcaaggactt tggacttggg gctgggcaaa aactcaagat 1860ccagaaccag catcttcagc aacaatcact gatccacaaa aagccaatag atttcataga 1920accttactac taacatggct tcctgccggg tatgttccta gcccaaaaca cagaagtccc 1980ctcatagcta acaccttatg ggggaatatg ctgcttgcaa cagaaagctt aaaaaatagt 2040gcagagctga cacctagtgg tcatcctttc tggggaatta caggaggagg actaggcatg 2100atggtttacc aagatcctcg agaaaatcat cctggattcc atatgcgctc ttccggatac 2160tctgcgggga tgatagcagg gcagacacac accttctcat tgaaattcag tcagacctac 2220accaaactca atgagcgtta cgcaaaaaac aacgtatctt ctaaaaatta ctcatgccaa 2280ggagaaatgc tcttctcatt gcaagaaggt ttcttgctga ctaaattagt tgggctttac 2340agctatggag accataactg tcaccatttc tatactcaag gagaaaatct aacatctcaa 2400gggacgttcc gcagtcaaac gatgggaggt gctgtctttt ttgatctccc tatgaaaccc 2460tttggatcaa cgcatatact gacagctccc tttttaggtg ctcttggtat ttattctagc 2520ctgtctcact ttactgaggt gggagcctat ccgcgaagct tttctacaaa gactcctttg 2580atcaatgtcc tagtccctat tggagttaaa ggtagcttta tgaatgctac ccacagacct 2640caagcctgga ctgtagaatt ggcataccaa cccgttctgt atagacaaga accagggatc 2700gcgacccagc tcctagccag taaaggtatt tggtttggta gtggaagccc ctcatcgcgt 2760catgccatgt cctataaaat ctcacagcaa acacaacctt tgagttggtt aactctccat 2820ttccagtatc atggattcta ctcctcttca accttctgta attatctcaa tggggaaatt 2880gctctgcgat tctag 2895

<210>172

<211>4593

<212>DNA

<213>衣原体属

<400>172atgagttccg agaaagatat aaaaagcacc tgttctaagt tttctttgtc tgtagtagca 60gctatccttg cctctgttag cgggttagct agttgcgtag atcttcatgc tggaggacag 120tctgtaaatg agctggtata tgtaggccct caagcggttt tattgttaga ccaaattcga 180gatctattcg ttgggtctaa agatagtcag gctgaaggac agtataggtt aattgtagga 240gatccaagtt ctttccaaga gaaagatgca gatactcttc ccgggaaggt agagcaaagt 300actttgttct cagtaaccaa tcccgtggtt ttccaaggtg tggaccaaca ggatcaagtc 360tcttcccaag ggttaatttg tagttttacg agcagcaacc ttgattctcc ccgtgacgga 420gaatcttttt taggtattgc ttttgttggg gatagtagta aggctggaat cacattaact 480gacgtgaaag cttctttgtc tggagcggct ttatattcta cagaagatct tatctttgaa 540aagattaagg gtggattgga atttgcatca tgttcttctc tagaacaggg gggagcttgt 600gcagctcaaa gtattttgat tcatgattgt caaggattgc aggttaaaca ctgtactaca 660gccgtgaatg ctgaggggtc tagtgcgaat gatcatcttg gatttggagg aggcgctttc 720tttgttacgg gttctctttc tggagagaaa agtctctata tgcctgcagg agatatggta 780gttgcgaatt gtgatggggc tatatctttt gaaggaaaca gcgcgaactt tgctaatgga 840ggagcgattg ctgcctctgg gaaagtgctt tttgtcgcta atgataaaaa gacttctttt 900atagagaacc gagctttgtc tggaggagcg attgcagcct cttctgatat tgcctttcaa 960aactgcgcag aactagtttt caaaggcaat tgtgcaattg gaacagagga taaaggttct 1020ttaggtggag gggctatatc ttctctaggc accgttcttt tgcaagggaa tcacgggata 1080acttgtgata agaatgagtc tgcttcgcaa ggaggcgcca tttttggcaa aaattgtcag 1140atttctgaca acgaggggcc agtggttttc agagatagta cagcttgctt aggaggaggc 1200gctattgcag ctcaagaaat tgtttctatt cagaacaatc aggctgggat ttccttcgag 1260ggaggtaagg ctagtttcgg aggaggtatt gcgtgtggat ctttttcttc cgcaggcggt 1320gcttctgttt tagggactat tgatatttcg aagaatttag gcgcgatttc gttctctcgt 1380actttatgta cgacctcaga tttaggacaa atggagtacc agggaggagg agctctattt 1440ggtgaaaata tttctctttc tgagaatgct ggtgtgctca cctttaaaga caacattgtg 1500aagacttttg cttcgaatgg gaaaattctg ggaggaggag cgattttagc tactggtaag 1560gtggaaatta ccaataattc cggaggaatt tcttttacag gaaatgcgag agctccacaa 1620gctcttccaa ctcaagagga gtttccttta ttcagcaaaa aagaagggcg accactctct 1680tcaggatatt ctgggggagg agcgatttta ggaagagaag tagctattct ccacaacgct 1740gcagtagtat ttgagcaaaa tcgtttgcag tgcagcgaag aagaagcgac attattaggt 1800tgttgtggag gaggcgctgt tcatgggatg gatagcactt cgattgttgg caactcttca 1860gtaagatttg gtaataatta cgcaatggga caaggagtct caggaggagc tcttttatct 1920aaaacagtgc agttagctgg aaatggaagc gtcgattttt ctcgaaatat tgctagtttg 1980ggaggaggag ctcttcaagc ttctgaagga aattgtgagc tagttgataa cggctatgtg 2040ctattcagag ataatcgagg gagggtttat gggggtgcta tttcttgctt acgtggagat 2100gtagtcattt ctggaaacaa gggtagagtt gaatttaaag acaacatagc aacacgtctt 2160tatgtggaag aaactgtaga aaaggttgaa gaggtagagc cagctcctga gcaaaaagac 2220aataatgagc tttctttctt agggagtgta gaacagagtt ttattactgc agctaatcaa 2280gctcttttcg catctgaaga tggggattta tcacctgagt catccatttc ttctgaagaa 2340cttgcgaaaa gaagagagtg tgctggagga gctatttttg caaaacgggt tcgtattgta 2400gataaccaag aggccgttgt attctcgaat aacttctctg atatttatgg cggcgccatt 2460tttacaggtt ctcttcgaga agaggataag ttagatgggc aaatccctga agtcttgatc 2520tcaggcaatg caggggatgt tgttttttcc ggaaattcct cgaagcgtga tgagcatctt 2580cctcatacag gtgggggagc catttgtact caaaatttga cgatttctca gaatacaggg 2640aatgttctgt tttataacaa cgtggcctgt tcgggaggag ctgttcgtat agaggatcat 2700ggtaatgttc ttttagaagc ttttggagga gatattgttt ttaaaggaaa ttcttctttc 2760agagcacaag gatccgatgc tatctatttt gcaggtaaag aatcgcatat tacagccctg 2820aatgctacgg aaggacatgc tattgttttc cacgacgcat tagtttttga aaatctaaaa 2880gaaaggaaat ctgctgaagt attgttaatc aatagtcgag aaaatccagg ttacactgga 2940tctattcgat ttttagaagc agaaagtaaa gttcctcaat gtattcatgt acaacaagga 3000agccttgagt tgctaaatgg agctacatta tgtagttatg gttttaaaca agatgctgga 3060gctaagttgg tattggctgc tggatctaaa ctgaagattt tagattcagg aactcctgta 3120caagggcatg ctatcagtaa acctgaagca gaaatcgagt catcttctga accagagggt 3180gcacattctc tttggattgc gaagaatgct caaacaacag ttcctatggt tgatatccat 3240actatttctg tagatttagc ctccttctct tctagtcaac aggaggggac agtagaagct 3300cctcaggtta ttgttcctgg aggaagttat gttcgatctg gagagcttaa tttggagtta 3360gttaacacaa caggtactgg ttatgaaaat catgctttgt tgaagaatga ggctaaagtt 3420ccattgatgt ctttcgttgc ttctagtgat gaagcttcag ccgaaatcag taacttgtcg 3480gtttctgatt tacagattca tgtagcaact ccagagattg aagaagacac atacggccat 3540atgggagatt ggtctgaggc taaaattcaa gatggaactc ttgtcattaa ttggaatcct 3600actggatatc gattagatcc tcaaaaagca ggggctttag tatttaatgc attatgggaa 3660gaaggggctg tcttgtctgc tctgaaaaat gcacgctttg ctcataatct cactgctcag 3720cgtatggaat tcgattattc tacaaatgtg tggggattcg cctttggtgg tttccgaact 3780ctatctgcag agaatctggt tgctattgat ggatacaaag gagcttatgg tggtgcttct 3840gctggagtcg atattcaatt gatggaagat tttgttctag gagttagtgg agctgctttc 3900ctaggtaaaa tggatagtca gaagtttgat gcggaggttt ctcggaaggg agttgttggt 3960tctgtatata caggattttt agctggatcc tggttcttca aaggacaata tagccttgga 4020gaaacacaga acgatatgaa aacgcgttat ggagtactag gagagtcgag tgcttcttgg 4080acatctcgag gagtactggc agatgcttta gttgaatacc gaagtttagt tggtcctgtg 4140agacctactt tttatgcttt gcatttcaat ccttatgtcg aagtatctta tgcttctatg 4200aaattccctg gctttacaga acaaggaaga gaagcgcgtt cttttgaaga cgcttccctt 4260accaatatca ccattccttt agggatgaag tttgaattgg cgttcataaa aggacagttt 4320tcagaggtga actctttggg aataagttat gcatgggaag cttatcgaaa agtagaagga 4380ggcgcggtgc agcttttaga agctgggttt gattgggagg gagctccaat ggatcttcct 4440agacaggagc tgcgtgtcgc tctggaaaat aatacggaat ggagttctta cttcagcaca 4500gtcttaggat taacagcttt ttgtggagga tttacttcta cagatagtaa actaggatat 4560gaggcgaata ctggattgcg attgatcttt taa 4593

<210>173

<211>5331

<212>DNA

<213>衣原体属

<400>173gcaatcatga aatttatgtc agctactgct gtatttgctg cagtactctc ctccgttact 60gaggcgagct cgatccaaga tcaaataaag aataccgact gcaatgttag caaagtagga 120tattcaactt ctcaagcatt tactgatatg atgctagcag acaacacaga gtatcgagct 180gctgatagtg tttcattcta tgacttttcg acatcttccg gattacctag aaaacatctt 240agtagtagta gtgaagcttc tccaacgaca gaaggagtgt cttcatcttc atctggagaa 300aatactgaga attcacaaga ttcagctccc tcttctggag aaactgataa gaaaacagaa 360gaagaactag acaatggcgg aatcatttat gctagagaga aactaactat ctcagaatct 420caggactctc tctctaatcc aagcatagaa ctccatgaca atagtttttt cttcggagaa 480ggtgaagtta tctttgatca cagagttgcc ctcaaaaacg gaggagctat ttatggagag 540aaagaggtag tctttgaaaa cataaaatct ctactagtag aagtaaatat ctcggtcgag 600aaagggggta gcgtctatgc aaaagaacga gtatctttag aaaatgttac cgaagcaacc 660ttctcctcca atggtgggga acaaggtggt ggtggaatct attcagaaca agatatgtta 720atcagtgatt gcaacaatgt acatttccaa gggaatgctg caggagcaac agcagtaaaa 780caatgtctgg atgaagaaat gatcgtattg ctcacagaat gcgttgatag cttatccgaa 840gatacactgg atagcactcc agaaacggaa cagactaagt caaatggaaa tcaagatggt 900tcgtctgaaa caaaagatac acaagtatca gaatcaccag aatcaactcc tagccccgac 960gatgttttag gtaaaggtgg tggtatctat acagaaaaat ctttgaccat cactggaatt 1020acagggacta tagattttgt cagtaacata gctaccgatt ctggagcagg tgtattcact 1080aaagaaaact tgtcttgcac caacacgaat agcctacagt ttttgaaaaa ctcggcaggt 1140caacatggag gaggagccta cgttactcaa accatgtctg ttactaatac aactagtgaa 1200agtataacta ctccccctct cgtaggagaa gtgattttct ctgaaaatac agctaaaggg 1260cacggtggtg gtatctgcac taacaaactt tctttatcta atttaaaaac ggtgactctc 1320actaaaaact ctgcaaagga gtctggagga gctattttta cagatctagc gtctatacca 1380acaacagata ccccagagtc ttctaccccc tcttcctcct cgcctgcaag cactcccgaa 1440gtagttgctt ctgctaaaat aaatcgattc tttgcctcta cggcagaacc ggcagcccct 1500tctctaacag aggctgagtc tgatcaaacg gatcaaacag aaacttctga tactaatagc 1560gatatagacg tgtcgattga gaacattttg aatgtcgcta tcaatcaaaa cacttctgcg 1620aaaaaaggag gggctattta cgggaaaaaa gctaaacttt cccgtattaa caatcttgaa 1680ctttcaggga attcatccca ggatgtagga ggaggtctct gtttaactga aagcgtagaa 1740tttgatgcaa ttggatcgct cttatcccac tataactctg ctgctaaaga aggtggggtt 1800attcattcta aaacggttac tctatctaac ctcaagtcta ccttcacttt tgcagataac 1860actgttaaag caatagtaga aagcactcct gaagctccag aagagattcc tccagtagaa 1920ggagaagagt ctacagcaac agaaaatccg aattctaata cagaaggaag ttcggctaac 1980actaaccttg aaggatctca aggggatact gctgatacag ggactggtgt tgttaacaat 2040gagtctcaag acacatcaga tactggaaac gctgaatctg gagaacaact acaagattct 2100acacaatcta atgaagaaaa tacccttccc aatagtagta ttgatcaatc taacgaaaac 2160acagacgaat catctgatag ccacactgag gaaataactg acgagagtgt ctcatcgtcc 2220tctaaaagtg gatcatctac tcctcaagat ggaggagcag cttcttcagg ggctccctca 2280ggagatcaat ctatctctgc aaacgcttgt ttagctaaaa gctatgctgc gagtactgat 2340agctcccctg tatctaattc ttcaggttca gacgttactg catcttctga taatccagac 2400tcttcctcat ctggagatag cgctggagac tctgaaggac cgactgagcc agaagctggt 2460tctacaacag aaactcctac tttaatagga ggaggtgcta tctatggaga aactgttaag 2520attgagaact tctctggcca aggaatattt tctggaaaca aagctatcga taacaccaca 2580gaaggctcct cttccaaatc taacgtcctc ggaggtgcgg tctatgctaa aacattgttt 2640aatctcgata gcgggagctc tagacgaact gtcaccttct ccgggaatac tgtctcttct 2700caatctacaa caggtcaggt tgctggagga gctatctact ctcctactgt aaccattgct 2760actcctgtag tattttctaa aaactctgca acaaacaatg ctaataacgc tacagatact 2820cagagaaaag acacctttgg aggagctatc ggagctactt ctgctgtttc tctatcagga 2880ggggctcatt tcttagaaaa cgttgctgac ctcggatctg ctattgggtt ggtgccagac 2940acacaaaata cagaaacagt gaaattagag tctggctcct actactttga aaaaaataaa 3000gctttaaaac gagctactat ttacgcacct gtcgtttcca ttaaagccta tactgcgaca 3060tttaaccaaa acagatctct agaagaagga agcgcgattt actttacaaa agaagcatct 3120attgagtctt taggctctgt tctcttcaca ggaaacttag taaccccaac gctaagcaca 3180actacagaag gcacaccagc cacaacctca ggagatgtaa caaaatatgg tgctgctatc 3240tttggacaaa tagcaagctc aaacggatct cagacggata accttcccct gaaactcatt 3300gcttcaggag gaaatatttg tttccgaaac aatgaatacc gtcctacttc ttctgatacc 3360ggaacctcta ctttctgtag tattgcggga gatgttaaat taaccatgca agctgcaaaa 3420gggaaaacga tcagtttctt tgatgcaatc cggacctcta ctaagaaaac aggtacacag 3480gcaactgcct acgatactct cgatattaat aaatctgagg attcagaaac tgtaaactct 3540gcgtttacag gaacgattct gttctcctct gaattacatg aaaataaatc ctatattcca 3600caaaacgtag ttctacacag tggatctctt gtattgaagc caaataccga gcttcatgtc 3660atttcttttg agcagaaaga aggctcttct ctcgttatga cacctggatc tgttctttcg 3720aaccagactg ttgctgatgg agctttggtc ataaataaca tgaccattga tttatccagc 3780gtagagaaaa atggtattgc tgaaggaaat atctttactc ctccagaatt gagaatcata 3840gacactacta caagtggaag cggtggaacc ccatctacag atagtgaaag taaccagaat 3900agtgatgata ccaaggagca aaataataat gacgcctcga atcaaggaga aagcgcgaat 3960ggatcgtctt ctcctgcagt agctgctgca cacacatctc gtacaagaaa ctttgccgct 4020gcagctacag ccacacctac gacaacacca acggctacaa ctacaacaag caaccaagta 4080atcctaggag gagaaatcaa actcatcgat cctaatggga ccttcttcca gaaccctgca 4140ttaagatccg accaacaaat ctccttgtta gtgctcccta cagactcatc aaaaatgcaa 4200gctcagaaaa tagtactgac gggtgatatt gctcctcaga aaggatatac aggaacactc 4260actctggatc ctgatcaact acaaaatgga acgatctcag cgctctggaa atttgactct 4320tatagacaat gggcttatgt acctagagac aatcatttct atgcgaactc gattctggga 4380tctcaaatgt caatggtcac agtcaaacaa ggcttgctca acgataaaat gaatctagct 4440cgctttgatg aagttagcta taacaacctg tggatatcag gactaggaac gatgctatcg 4500caagtaggaa cacctacttc tgaagaattc acttattaca gcagaggagc ttctgttgcc 4560ttagatgcta aaccagccca tgatgtgatt gttggagctg catttagtaa gatgatcggg 4620aaaacaaaat ccttgaaaag agagaataac tacactcaca aaggatccga atattcttac 4680caagcatcgg tatacggagg caaaccattc cactttgtaa tcaataaaaa aacggaaaaa 4740tcgctaccgc tattgttaca aggagtcatc tcttacggat atatcaaaca tgatacagtg 4800actcactatc caacgatccg tgaacgaaac caaggagaat gggaagactt aggatggctg 4860acagctctcc gtgtctcctc tgtcttaaga actcctgcac aaggggatac taaacgtatc 4920actgtttacg gagaattgga atactccagt atccgtcaga aacaattcac agaaacagaa 4980tacgatcctc gttacttcga caactgcacc tatagaaact tagcaattcc tatggggtta 5040gcattcgaag gagagctctc tggtaacgat attttgatgt acaacagatt ctctgtagca 5100tacatgccat caatctatcg aaattctcca acatgcaaat accaagtgct ctcttcagga 5160gaaggcggag aaattatttg tggagtaccg acaagaaact cagctcgcgg agaatacagc 5220acgcagctgt acccgggacc tttgtggact ctgtatggat cctacacgat agaagcagac 5280gcacatacac tagctcatat gatgaactgc ggtgctcgta tgacattcta a 5331

<210>174

<211>5265

<212>DNA

<213>衣原体属

<400>174gcaatcatga aatggctgtc agctactgcg gtgtttgctg ctgttctccc ctcagtttca 60gggttttgct tcccagaacc taaagaatta aatttctctc gcgtagaaac ttcttcctct 120accactttta ctgaaacaat tggagaagct ggggcagaat atatcgtctc tggtaacgca 180tctttcacaa aatttaccaa cattcctact accgatacaa caactcccac gaactcaaac 240tcctctagct ctagcggaga aactgcttcc gtttctgagg atagtgactc tacaacaacg 300actcctgatc ctaaaggtgg cggcgccttt tataacgcgc actccggagt tttgtccttt 360atgacacgat caggaacaga aggttcctta actctgtctg agataaaaat gactggtgaa 420ggcggtgcta tcttctctca aggagagctg ctatttacag atctgacaag tctaaccatc 480caaaataact tatcccagct atccggagga gcgatttttg gaggatctac aatctcccta 540tcagggatta ctaaagcgac tttctcctgc aactctgcag aagttcctgc tcctgttaag 600aaacctacag aacctaaagc tcaaacagca agcgaaacgt cgggttctag tagttctagc 660ggaaatgatt cggtgtcttc ccccagttcc agtagagctg aacccgcagc agctaatctt 720caaagtcact ttatttgtgc tacagctact cctgctgctc aaaccgatac agaaacatca 780actccctctc ataagccagg atctggggga gctatctatg ctaaaggcga ccttactatc 840gcagactctc aagaggtact attctcaata aataaagcta ctaaagatgg aggagcgatc 900tttgctgaga aagatgtttc tttcgagaat attacatcat taaaagtaca aactaacggt 960gctgaagaaa agggaggagc tatctatgct aaaggtgacc tctcaattca atcttctaaa 1020cagagtcttt ttaattctaa ctacagtaaa caaggtgggg gggctctata tgttgaagga 1080ggtataaact tccaagatct tgaagaaatt cgcattaagt acaataaagc tggaacgttc 1140gaaacaaaaa aaatcacttt accttcttta aaagctcaag catctgcagg aaatgcagat 1200gcttgggcct cttcctctcc tcaatctggt tctggagcaa ctacagtctc cgactcagga 1260gactctagct ctggctcaga ctcggatacc tcagaaacag ttccagtcac agctaaaggc 1320ggtgggcttt atactgataa gaatctttcg attactaaca tcacaggaat tatcgaaatt 1380gcaaataaca aagcgacaga tgttggaggt ggtgcttacg taaaaggaac ccttacttgt 1440gaaaactctc accgtctaca atttttgaaa aactcttccg ataaacaagg tggaggaatc 1500tacggagaag acaacatcac cctatctaat ttgacaggga agactctatt ccaagagaat 1560actgccaaag aagagggcgg tggactcttc ataaaaggta cagataaagc tcttacaatg 1620acaggactgg atagtttctg tttaattaat aacacatcag aaaaacatgg tggtggagcc 1680tttgttacca aagaaatctc tcagacttac acctctgatg tggaaacaat tccaggaatc 1740acgcctgtac atggtgaaac agtcattact ggcaataaat ctacaggagg taatggtgga 1800ggcgtgtgta caaaacgtct tgccttatct aaccttcaaa gcatttctat atccgggaat 1860tctgcagcag aaaatggtgg tggagcccac acatgcccag atagcttccc aacggcggat 1920actgcagaac agcccgcagc agcttctgcc gcgacgtcta ctcccaaatc tgccccggtc 1980tcaactgctc taagcacacc ttcatcttct accgtctctt cattaacctt actagcagcc 2040tcttcacaag cctctcctgc aacctctaat aaggaaactc aagatcctaa tgctgataca 2100gacttattga tcgattatgt agttgatacg actatcagca aaaacactgc taagaaaggc 2160ggtggaatct atgctaaaaa agccaagatg tcccgcatag accaactgaa tatctctgag 2220aactccgcta cagagatagg tggaggtatc tgctgtaaag aatctttaga actagatgct 2280ctagtctcct tatctgtaac agagaacctt gttgggaaag aaggtggagg cttacatgct 2340aaaactgtaa atatttctaa tctgaaatca ggcttctctt tctcgaacaa caaagcaaac 2400tcctcatcca caggagtcgc aacaacagct tcagcacctg ctgcagctgc tgcttcccta 2460caagcagccg cagcagccgc accatcatct ccagcaacac caacttattc aggtgtagta 2520ggaggagcta tctatggaga aaaggttaca ttctctcaat gtagcgggac ttgtcagttc 2580tctgggaacc aagctatcga taacaatccc tcccaatcat cgttgaacgt acaaggagga 2640gccatctatg ccaaaacctc tttgtctatt ggatcttccg atgctggaac ctcctatatt 2700ttctcgggga acagtgtctc cactgggaaa tctcaaacaa cagggcaaat agcgggagga 2760gcgatctact cccctactgt tacattgaat tgtcctgcga cattctctaa caatacagcc 2820tctatagcta caccgaagac ttcttctgaa gatggatcct caggaaattc tattaaagat 2880accattggag gagccattgc agggacagcc attaccctat ctggagtctc tcgattttca 2940gggaatacgg ctgatttagg agctgcaata ggaactctag ctaatgcaaa tacacccagt 3000gcaactagcg gatctcaaaa tagcattaca gaaaaaatta ctttagaaaa cggttctttt 3060atttttgaaa gaaaccaagc taataaacgt ggagcgattt actctcctag cgtttccatt 3120aaagggaata atattacctt caatcaaaat acatccactc atgatggaag cgctatctac 3180tttacaaaag atgctacgat tgagtcttta ggatctgttc tttttacagg aaataacgtt 3240acagctacac aagctagttc tgcaacatct ggacaaaata caaatactgc caactatggg 3300gcagccatct ttggagatcc aggaaccact caatcgtctc aaacagatgc cattttaacc 3360cttcttgctt cttctggaaa cattactttt agcaacaaca gtttacagaa taaccaaggt 3420gatactcccg ctagcaagtt ttgtagtatt gcaggatacg tcaaactctc tctacaagcc 3480gctaaaggga agactattag ctttttcgat tgtgtgcaca cctctaccaa aaaaacaggt 3540tcaacacaaa acgtttatga aactttagat attaataaag aagagaacag taatccatat 3600acaggaacta ttgtgttctc ttctgaatta catgaaaaca aatcttacat cccacagaat 3660gcaatccttc acaacggaac tttagttctt aaagagaaaa cagaactcca cgtagtctct 3720tttgagcaga aagaagggtc taaattaatt atggaacccg gagctgtgtt atctaaccaa 3780aacatagcta acggagctct agctatcaat gggttaacga ttgatctttc cagtatgggg 3840actcctcaag caggggaaat cttctctcct ccagaattac gtatcgttgc cacgacctct 3900agtgcatccg gaggaagcgg ggtcagcagt agtataccaa caaatcctaa aaggatttct 3960gcagcagtgc cttcaggttc tgccgcaact actccaacta tgagcgagaa caaagttttc 4020ctaacaggag accttacttt aatagatcct aatggaaact tttaccaaaa ccctatgtta 4080ggaagcgatc tagatgtacc actaattaag cttccgacta acacaagtga cgtccaagtc 4140tatgatttaa ctttatctgg ggatcttttc cctcagaaag ggtacatggg aacctggaca 4200ttagattcta atccacaaac agggaaactt caagccagat ggacattcga tacctatcgt 4260cgctgggtat acatacctag ggataatcat ttttatgcga actctatctt aggctcccaa 4320aactcaatga ttgttgtgaa gcaagggctt atcaacaaca tgttgaataa tgcccgcttc 4380gatgatatcg cttacaataa cttctgggtt tcaggagtag gaactttctt agctcaacaa 4440ggaactcctc tttccgaaga attcagttac tacagccgcg gaacttcagt tgccatcgat 4500gccaaaccta gacaagattt tatcctagga gctgcattta gtaagatagt ggggaaaacc 4560aaagccatca aaaaaatgca taattacttc cataagggct ctgagtactc ttaccaagct 4620tctgtctatg gaggtaaatt cctgtatttc ttgctcaata agcaacatgg ttgggcactt 4680cctttcctaa tacaaggagt cgtgtcctat ggacatatta aacatgatac aacaacactt 4740tacccttcta tccatgaaag aaataaagga gattgggaag atttaggatg gttagcggat 4800cttcgtatct ctatggatct taaagaacct tctaaagatt cttctaaacg gatcactgtc 4860tatggggaac tcgagtattc cagcattcgc cagaaacagt tcacagaaat cgattacgat 4920ccaagacact tcgatgattg tgcttacaga aatctgtcgc ttcctgtggg atgcgctgtc 4980gaaggagcta tcatgaactg taatattctt atgtataata agcttgcatt agcctacatg 5040ccttctatct acagaaataa tcctgtctgt aaatatcggg tattgtcttc gaatgaagct 5100ggtcaagtta tctgcggagt gccaactaga acctctgcta gagcagaata cagtactcaa 5160ctatatcttg gtcccttctg gactctctac ggaaactata ctatcgatgt aggcatgtat 5220acgctatcgc aaatgactag ctgcggtgct cgcatgatct tctaa 5265

<210>175

<211>880

<212>PRT

<213>衣原体属

<220>

<221>VARIANT

<222>336

<223>Xaa＝任何氨基酸

<400>175Ala Ile Met Arg Pro Asp His Met Asn Phe Cys Cys Leu Cys Ala Ala1 5 10 15Ile Leu Ser Ser Thr Ala Val Leu Phe Gly Gln Asp Pro Leu Gly Glu

20 25 30Thr Ala Leu Leu Thr Lys Asn Pro Asn His Val Val Cys Thr Phe Phe

35 40 45Glu Asp Cys Thr Met Glu Ser Leu Phe Pro Ala Leu Cys Ala His Ala

50 55 60Ser Gln Asp Asp Pro Leu Tyr Val Leu Gly Asn Ser Tyr Cys Trp Phe65 70 75 80Val Ser Lys Leu His Ile Thr Asp Pro Lys Glu Ala Leu Phe Lys Glu

85 90 95Lys Gly Asp Leu Ser Ile Gln Asn Phe Arg Phe Leu Ser Phe Thr Asp

100 105 110Cys Ser Ser Lys Glu Ser Ser Pro Ser Ile Ile His Gln Lys Asn Gly

115 120 125Gln Leu Ser Leu Arg Asn Asn Gly Ser Met Ser Phe Cys Arg Asn His

130 135 140Ala Glu Gly Ser Gly Gly Ala Ile Ser Ala Asp Ala Phe Ser Leu Gln145 150 155 160His Asn Tyr Leu Phe Thr Ala Phe Glu Glu Asn Ser Ser Lys Gly Asn

165 170 175Gly Gly Ala Ile Gln Ala Gln Thr Phe Ser Leu Ser Arg Asn Val Ser

180 185 190Pro Ile Ser Phe Ala Arg Asn Arg Ala Asp Leu Asn Gly Gly Ala Ile

195 200 205Cys Cys Ser Asn Leu Ile Cys Ser Gly Asn Val Asn Pro Leu Phe Phe

210 215 220Thr Gly Asn Ser Ala Thr Asn Gly Gly Ala Ile Cys Cys Ile Ser Asp225 230 235 240Leu Asn Thr Ser Glu Lys Gly Ser Leu Ser Leu Ala Cys Asn Gln Glu

245 250 255Thr Leu Phe Ala Ser Asn Ser Ala Lys Glu Lys Gly Gly Ala Ile Tyr

260 265 270Ala Lys His Met Val Leu Arg Tyr Asn Gly Pro Val Ser Phe Ile Asn

275 280 285Asn Ser Ala Lys Ile Gly Gly Ala Ile Ala Ile Gln Ser Gly Gly Ser

290 295 300Leu Ser Ile Leu Ala Gly Glu Gly Ser Val Leu Phe Gln Asn Asn Ser305 310 315 320Gln Arg Thr Ser Asp Gln Gly Leu Val Arg Asn Ala Ile Tyr Leu Xaa

325 330 335Lys Asp Ala Ile Leu Ser Ser Leu Glu Ala Arg Asn Gly Asp Ile Leu

340 345 350Phe Phe Asp Pro Ile Val Gln Glu Ser Ser Ser Lys Glu Ser Pro Leu

355 360 365Pro Ser Ser Leu Gln Ala Ser Val Thr Ser Pro Thr Pro Ala Thr Ala

370 375 380Ser Pro Leu Val Ile Gln Thr Ser Ala Asn Arg Ser Val Ile Phe Ser385 390 395 400Ser Glu Arg Leu Ser Glu Glu Glu Lys Thr Pro Asp Asn Leu Thr Ser

405 410 415Gln Leu Gln Gln Pro Ile Glu Leu Lys Ser Gly Arg Leu Val Leu Lys

420 425 430Asp Arg Ala Val Leu Ser Ala Pro Ser Leu Ser Gln Asp Pro Gln Ala

435 440 445Leu Leu Ile Met Glu Ala Gly Thr Ser Leu Lys Thr Ser Ser Asp Leu

450 455 460Lys Leu Ala Thr Leu Ser Ile Pro Leu His Ser Leu Asp Thr Glu Lys465 470 475 480Ser Val Thr Ile His Ala Pro Asn Leu Ser Ile Gln Lys Ile Phe Leu

485 490 495Ser Asn Ser Gly Asp Glu Asn Phe Tyr Glu Asn Val Glu Leu Leu Ser

500 505 510Lys Glu Gln Asn Asn Ile Pro Leu Leu Thr Leu Pro Lys Glu Gln Ser

515 520 525His Leu His Leu Pro Asp Gly Asn Leu Ser Ser His Phe Gly Tyr Gln

530 535 540Gly Asp Trp Thr Phe Ser Trp Lys Asp Ser Asp Glu Gly His Ser Leu545 550 555 560Ile Ala Asn Trp Thr Pro Lys Asn Tyr Val Pro His Pro Glu Arg Gln

565 570 575Ser Thr Leu Val Ala Asn Thr Leu Trp Asn Thr Tyr Ser Asp Met Gln

580 585 590Ala Val Gln Ser Met Ile Asn Thr Thr Ala His Gly Gly Ala Tyr Leu

595 600 605Phe Gly Thr Trp Gly Ser Ala Val Ser Asn Leu Phe Tyr Val His Asp

610 615 620Ser Ser Gly Lys Pro Ile Asp Asn Trp His His Arg Ser Leu Gly Tyr625 630 635 640Leu Phe Gly Ile Ser Thr His Ser Leu Asp Asp His Ser Phe Cys Leu

645 650 655Ala Ala Gly Gln Leu Leu Gly Lys Ser Ser Asp Ser Phe Ile Thr Ser

660 665 670Thr Glu Thr Thr Ser Tyr Ile Ala Thr Val Gln Ala Gln Leu Ala Thr

675 680 685Ser Leu Met Lys Ile Ser Ala Gln Ala Cys Tyr Asn Glu Ser Ile His

690 695 700Glu Leu Lys Thr Lys Tyr Arg Ser Phe Ser Lys Glu Gly Phe Gly Ser705 710 715 720Trp His Ser Val Ala Val Ser Gly Glu Val Cys Ala Ser Ile Pro Ile

725 730 735Val Ser Asn Gly Ser Gly Leu Phe Ser Ser Phe Ser Ile Phe Ser Lys

740 745 750Leu Gln Gly Phe Ser Gly Thr Gln Asp Gly Phe Glu Glu Ser Ser Gly

755 760 765Glu Ile Arg Ser Phe Ser Ala Ser Ser Phe Arg Asn Ile Ser Leu Pro

770 775 780Ile Gly Ile Thr Phe Glu Lys Lys Ser Gln Lys Thr Arg Thr Tyr Tyr785 790 795 800Tyr Phe Leu Gly Ala Tyr Ile Gln Asp Leu Lys Arg Asp Val Glu Ser

805 810 815Gly Pro Val Val Leu Leu Lys Asn Ala Val Ser Trp Asp Ala Pro Met

820 825 830Ala Asn Leu Asp Ser Arg Ala Tyr Met Phe Arg Leu Thr Asn Gln Arg

835 840 845Ala Leu His Arg Leu Gln Thr Leu Leu Asn Val Ser Cys Val Leu Arg

850 855 860Gly Gln Ser His Ser Tyr Ser Leu Asp Leu Gly Thr Thr Tyr Arg Phe865 870 875 880

<210>176

<211>982

<212>PRT

<213>衣原体属

<220>

<221>VARIANT

<222>981

<223>Xaa＝任何氨基酸

<400>176Met Ile Pro Gln Gly Ile Tyr Asp Gly Glu Thr Leu Thr Val Ser Phe1 5 10 15Pro Tyr Thr Val Ile Gly Asp Pro Ser Gly Thr Thr Val Phe Ser Ala

20 25 30Gly Glu Leu Thr Leu Lys Asn Leu Asp Asn Ser Ile Ala Ala Leu Pro

35 40 45Leu Ser Cys Phe Gly Asn Leu Leu Gly Ser Phe Thr Val Leu Gly Arg

50 55 60Gly His Ser Leu Thr Phe Glu Asn Ile Arg Thr Ser Thr Asn Gly Ala65 70 75 80Ala Leu Ser Asn Ser Ala Ala Asp Gly Leu Phe Thr Ile Glu Gly Phe

85 90 95Lys Glu Leu Ser Phe Ser Asn Cys Asn Ser Leu Leu Ala Val Leu Pro

100 105 110Ala Ala Thr Thr Asn Lys Gly Ser Gln Thr Pro Thr Thr Thr Ser Thr

115 120 125Pro Ser Asn Gly Thr Ile Tyr Ser Lys Thr Asp Leu Leu Leu Leu Asn

130 135 140Asn Glu Lys Phe Ser Phe Tyr Ser Asn Leu Val Ser Gly Asp Gly Gly145 150 155 160Ala Ile Asp Ala Lys Ser Leu Thr Val Gln Gly Ile Ser Lys Leu Cys

165 170 175Val Phe Gln Glu Asn Thr Ala Gln Ala Asp Gly Gly Ala Cys Gln Val

180 185 190Val Thr Ser Phe Ser Ala Met Ala Asn Glu Ala Pro Ile Ala Phe Val

195 200 205Ala Asn Val Ala Gly Val Arg Gly Gly Gly Ile Ala Ala Val Gln Asp

210 215 220Gly Gln Gln Gly Val Ser Ser Ser Thr Ser Thr Glu Asp Pro Val Val225 230 235 240Ser Phe Ser Arg Asn Thr Ala Val Glu Phe Asp Gly Asn Val Ala Arg

245 250 255Val Gly Gly Gly Ile Tyr Ser Tyr Gly Asn Val Ala Phe Leu Asn Asn

260 265 270Gly Lys Thr Leu Phe Leu Asn Asn Val Ala Ser Pro Val Tyr Ile Ala

275 280 285Ala Lys Gln Pro Thr Ser Gly Gln Ala Ser Asn Thr Ser Asn Asn Tyr

290 295 300Gly Asp Gly Gly Ala Ile Phe Cys Lys Asn Gly Ala Gln Ala Gly Ser305 310 315 320Asn Asn Ser Gly Ser Val Ser Phe Asp Gly Glu Gly Val Val Phe Phe

325 330 335Ser Ser Asn Val Ala Ala Gly Lys Gly Gly Ala Ile Tyr Ala Lys Lys

340 345 350Leu Ser Val Ala Asn Cys Gly Pro Val Gln Phe Leu Arg Asn Ile Ala

355 360 365Asn Asp Gly Gly Ala Ile Tyr Leu Gly Glu Ser Gly Glu Leu Ser Leu

370 375 380Ser Ala Asp Tyr Gly Asp Ile Ile Phe Asp Gly Asn Leu Lys Arg Thr385 390 395 400Ala Lys Glu Asn Ala Ala Asp Val Asn Gly Val Thr Val Ser Ser Gln

405 410 415Ala Ile Ser Met Gly Ser Gly Gly Lys Ile Thr Thr Leu Arg Ala Lys

420 425 430Ala Gly His Gln Ile Leu Phe Asn Asp Pro Ile Glu Met Ala Asn Gly

435 440 445Asn Asn Gln Pro Ala Gln Ser Ser Lys Leu Leu Lys Ile Asn Asp Gly

450 455 460Glu Gly Tyr Thr Gly Asp Ile Val Phe Ala Asn Gly Ser Ser Thr Leu465 470 475 480Tyr Gln Asn Val Thr Ile Glu Gln Gly Arg Ile Val Leu Arg Glu Lys

485 490 495Ala Lys Leu Ser Val Asn Ser Leu Ser Gln Thr Gly Gly Ser Leu Tyr

500 505 510Met Glu Ala Gly Ser Thr Leu Asp Phe Val Thr Pro Gln Pro Pro Gln

515 520 525Gln Pro Pro Ala Ala Asn Gln Leu Ile Thr Leu Ser Asn Leu His Leu

530 535 540Ser Leu Ser Ser Leu Leu Ala Asn Asn Ala Val Thr Asn Pro Pro Thr545 550 555 560Asn Pro Pro Ala Gln Asp Ser His Pro Ala Val Ile Gly Ser Thr Thr

565 570 575Ala Gly Ser Val Thr Ile Ser Gly Pro Ile Phe Phe Glu Asp Leu Asp

580 585 590Asp Thr Ala Tyr Asp Arg Tyr Asp Trp Leu Gly Ser Asn Gln Lys Ile

595 600 605Ash Val Leu Lys Leu Gln Leu Gly Thr Lys Pro Pro Ala Asn Ala Pro

610 615 620Ser Asp Leu Thr Leu Gly Asn Glu Met Pro Lys Tyr Gly Tyr Gln Gly625 630 635 640Ser Trp Lys Leu Ala Trp Asp Pro Asn Thr Ala Asn Asn Gly Pro Tyr

645 650 655Thr Leu Lys Ala Thr Trp Thr Lys Thr Gly Tyr Asn Pro Gly Pro Glu

660 665 670Arg Val Ala Ser Leu Val Pro Asn Ser Leu Trp Gly Ser Ile Leu Asp

675 680 685Ile Arg Ser Ala His Ser Ala Ile Gln Ala Ser Val Asp Gly Arg Ser

690 695 700Tyr Cys Arg Gly Leu Trp Val Ser Gly Val Ser Asn Phe Phe Tyr His705 710 715 720Asp Arg Asp Ala Leu Gly Gln Gly Tyr Arg Tyr Ile Ser Gly Gly Tyr

725 730 735Ser Leu Gly Ala Asn Ser Tyr Phe Gly Ser Ser Met Phe Gly Leu Ala

740 745 750Phe Thr Glu Val Phe Gly Arg Ser Lys Asp Tyr Val Val Cys Arg Ser

755 760 765Asn His His Ala Cys Ile Gly Ser Val Tyr Leu Ser Thr Gln Gln Ala

770 775 780Leu Cys Gly Ser Tyr Leu Phe Gly Asp Ala Phe Ile Arg Ala Ser Tyr785 790 795 800Gly Phe Gly Asn Gln His Met Lys Thr Ser Tyr Thr Phe Ala Glu Glu

805 810 815Ser Asp Val Arg Trp Asp Asn Asn Cys Leu Ala Gly Glu Ile Gly Ala

820 825 830Gly Leu Pro Ile Val Ile Thr Pro Ser Lys Leu Tyr Leu Asn Glu Leu

835 840 845Arg Pro Phe Val Gln Ala Glu Phe Ser Tyr Ala Asp His Glu Ser Phe

850 855 860Thr Glu Glu Gly Asp Gln Ala Arg Ala Phe Lys Ser Gly His Leu Leu865 870 875 880Asn Leu Ser Val Pro Val Gly Val Lys Phe Asp Arg Cys Ser Ser Thr

885 890 895His Pro Asn Lys Tyr Ser Phe Met Ala Ala Tyr Ile Cys Asp Ala Tyr

900 905 910Arg Thr Ile Ser Gly Thr Glu Thr Thr Leu Leu Ser His Gln Glu Thr

915 920 925Trp Thr Thr Asp Ala Phe His Leu Ala Arg His Gly Val Val Val Arg

930 935 940Gly Ser Met Tyr Ala Ser Leu Thr Ser Asn Ile Glu Val Tyr Gly His945 950 955 960Gly Arg Tyr Glu Tyr Arg Asp Ala Ser Arg Gly Tyr Gly Leu Ser Ala

965 970 975Gly Ser Lys Val Xaa Phe

980

<210>177

<211>964

<212>PRT

<213>衣原体属

<400>177Met Lys Lys Ala Phe Phe Phe Phe Leu Ile Gly Asn Ser Leu Ser Gly1 5 10 15Leu Ala Arg Glu Val Pro Ser Arg Ile Phe Leu Met Pro Asn Ser Val

20 25 30Pro Asp Pro Thr Lys Glu Ser Leu Ser Asn Lys Ile Ser Leu Thr Gly

35 40 45Asp Thr His Asn Leu Thr Asn Cys Tyr Leu Asp Asn Leu Arg Tyr Ile

50 55 60Leu Ala Ile Leu Gln Lys Thr Pro Asn Glu Gly Ala Ala Val Thr Ile65 70 75 80Thr Asp Tyr Leu Ser Phe Phe Asp Thr Gln Lys Glu Gly Ile Tyr Phe

85 90 95Ala Lys Ash Leu Thr Pro Glu Ser Gly Gly Ala Ile Gly Tyr Ala Ser

100 105 110Pro Asn Ser Pro Thr Val Glu Ile Arg Asp Thr Ile Gly Pro Val Ile

115 120 125Phe Glu Asn Asn Thr Cys Cys Arg Leu Phe Thr Trp Arg Asn Pro Tyr

130 135 140Ala Ala Asp Lys Ile Arg Glu Gly Gly Ala Ile His Ala Gln Asn Leu145 150 155 160Tyr Ile Asn His Asn His Asp Val Val Gly Phe Met Lys Asn Phe Ser

165 170 175Tyr Val Gln Gly Gly Ala Ile Ser Thr Ala Asn Thr Phe Val Val Ser

180 185 190Glu Asn Gln Ser Cys Phe Leu Phe Met Asp Asn Ile Cys Ile Gln Thr

195 200 205Asn Thr Ala Gly Lys Gly Gly Ala Ile Tyr Ala Gly Thr Ser Asn Ser

210 215 220Phe Glu Ser Asn Asn Cys Asp Leu Phe Phe Ile Asn Asn Ala Cys Cys225 230 235 240Ala Gly Gly Ala Ile Phe Ser Pro Ile Cys Ser Leu Thr Gly Asn Arg

245 250 255Gly Asn Ile Val Phe Tyr Asn Asn Arg Cys Phe Lys Ash Val Glu Thr

260 265 270Ala Ser Ser Glu Ala Ser Asp Gly Gly Ala Ile Lys Val Thr Thr Arg

275 280 285Leu Asp Val Thr Gly Asn Arg Gly Arg Ile Phe Phe Ser Asp Asn Ile

290 295 300Thr Lys Asn Tyr Gly Gly Ala Ile Tyr Ala Pro Val Val Thr Leu Val305 310 315 320Asp Asn Gly Pro Thr Tyr Phe Ile Asn Asn Ile Ala Asn Asn Lys Gly

325 330 335Gly Ala Ile Tyr Ile Asp Gly Thr Ser Asn Ser Lys Ile Ser Ala Asp

340 345 350Arg His Ala Ile Ile Phe Asn Glu Asn Ile Val Thr Asn Val Thr Asn

355 360 365Ala Asn Gly Thr Ser Thr Ser Ala Asn Pro Pro Arg Arg Asn Ala Ile

370 375 380Thr Val Ala Ser Ser Ser Gly Glu Ile Leu Leu Gly Ala Gly Ser Ser385 390 395 400Gln Asn Leu Ile Phe Tyr Asp Pro Ile Glu Val Ser Asn Ala Gly Val

405 410 415Ser Val Ser Phe Asn Lys Glu Ala Asp Gln Thr Gly Ser Val Val Phe

420 425 430Ser Gly Ala Thr Val Asn Ser Ala Asp Phe His Gln Arg Asn Leu Gln

435 440 445Thr Lys Thr Pro Ala Pro Leu Thr Leu Ser Asn Gly Phe Leu Cys Ile

450 455 460Glu Asp His Ala Gln Leu Thr Val Asn Arg Phe Thr Gln Thr Gly Gly465 470 475 480Val Val Ser Leu Gly Asn Gly Ala Val Leu Ser Cys Tyr Lys Asn Gly

485 490 495Thr Gly Asp Ser Ala Ser Asn Ala Ser Ile Thr Leu Lys His Ile Gly

500 505 510Leu Asn Leu Ser Ser Ile Leu Lys Ser Gly Ala Glu Ile Pro Leu Leu

515 520 525Trp Val Glu Pro Thr Asn Asn Ser Asn Asn Tyr Thr Ala Asp Thr Ala

530 535 540Ala Thr Phe Ser Leu Ser Asp Val Lys Leu Ser Leu Ile Asp Asp Tyr545 550 555 560Gly Asn Ser Pro Tyr Glu Ser Thr Asp Leu Thr His Ala Leu Ser Ser

565 570 575Gln Pro Met Leu Ser Ile Ser Glu Ala Ser Asp Asn Gln Leu Gln Ser

580 585 590Glu Asn Ile Asp Phe Ser Gly Leu Asn Val Pro His Tyr Gly Trp Gln

595 600 605Gly Leu Trp Thr Trp Gly Trp Ala Lys Thr Gln Asp Pro Glu Pro Ala

610 615 620Ser Ser Ala Thr Ile Thr Asp Pro Gln Lys Ala Asn Arg Phe His Arg625 630 635 640Thr Leu Leu Leu Thr Trp Leu Pro Ala Gly Tyr Val Pro Ser Pro Lys

645 650 655His Arg Ser Pro Leu Ile Ala Asn Thr Leu Trp Gly Asn Met Leu Leu

660 665 670Ala Thr Glu Ser Leu Lys Asn Ser Ala Glu Leu Thr Pro Ser Gly His

675 680 685Pro Phe Trp Gly Ile Thr Gly Gly Gly Leu Gly Met Met ValTyr Gln

690 695 700Asp Pro Arg Glu Asn His Pro Gly Phe His Met Arg Ser Ser Gly Tyr705 710 715 720Ser Ala Gly Met Ile Ala Gly Gln Thr His Thr Phe Ser Leu Lys Phe

725 730 735Ser Gln Thr Tyr Thr Lys Leu Asn Glu Arg Tyr Ala Lys Asn Asn Val

740 745 750Ser Ser Lys Asn Tyr Ser Cys Gln Gly Glu Met Leu Phe Ser Leu Gln

755 760 765Glu Gly Phe Leu Leu Thr Lys Leu Val Gly Leu Tyr Ser Tyr Gly Asp

770 775 780His Asn Cys His His Phe Tyr Thr Gln Gly Glu Asn Leu Thr Ser Gln785 790 795 800Gly Thr Phe Arg Ser Gln Thr Met Gly Gly Ala Val Phe Phe Asp Leu

805 810 815Pro Met Lys Pro Phe Gly Ser Thr His Ile Leu Thr Ala Pro Phe Leu

820 825 830Gly Ala Leu Gly Ile Tyr Ser Ser Leu Ser His Phe Thr Glu Val Gly

835 840 845Ala Tyr Pro Arg Ser Phe Ser Thr Lys Thr Pro Leu Ile Asn Val Leu

850 855 860Val Pro Ile Gly Val Lys Gly Ser Phe Met Asn Ala Thr His Arg Pro865 870 875 880Gln Ala Trp Thr Val Glu Leu Ala Tyr Gln Pro Val Leu Tyr Arg Gln

885 890 895Glu Pro Gly Ile Ala Thr Gln Leu Leu AIa Ser Lys Gly Ile Trp Phe

900 905 910Gly Ser Gly Ser Pro Ser Ser Arg His Ala Met Ser Tyr Lys Ile Ser

915 920 925Gln Gln Thr Gln Pro Leu Ser Trp Leu Thr Leu His Phe Gln Tyr His

930 935 940Gly Phe Tyr Ser Ser Ser Thr Phe Cys Asn Tyr Leu Asn Gly Glu Ile945 950 955 960Ala Leu Arg Phe

<210>178

<211>1530

<212>PRT

<213>衣原体属

<400>178Met Ser Ser Glu Lys Asp Ile Lys Ser Thr Cys Ser Lys Phe Ser Leu1 5 10 15Ser Val Val Ala Ala Ile Leu Ala Ser Val Ser Gly Leu Ala Ser Cys

20 25 30Val Asp Leu His Ala Gly Gly Gln Ser Val Asn Glu Leu Val Tyr Val

35 40 45Gly Pro Gln Ala Val Leu Leu Leu Asp Gln Ile Arg Asp Leu Phe Val

50 55 60Gly Ser Lys Asp Ser Gln Ala Glu Gly Gln Tyr Arg Leu Ile Val Gly65 70 75 80Asp Pro Ser Ser Phe Gln Glu Lys Asp Ala Asp Thr Leu Pro Gly Lys

85 90 95Val Glu Gln Ser Thr Leu Phe Ser Val Thr Asn Pro Val Val Phe Gln

100 105 110Gly Val Asp Gln Gln Asp Gln Val Ser Ser Gln Gly Leu Ile Cys Ser

115 120 125Phe Thr Ser Ser Asn Leu Asp Ser Pro Arg Asp Gly Glu Ser Phe Leu

130 135 140Gly Ile Ala Phe Val Gly Asp Ser Ser Lys Ala Gly Ile Thr Leu Thr145 150 155 160Asp Val Lys Ala Ser Leu Ser Gly Ala Ala Leu Tyr Ser Thr Glu Asp

165 170 175Leu Ile Phe Glu Lys Ile Lys Gly Gly Leu Glu Phe Ala Ser Cys Ser

180 185 190Ser Leu Glu Gln Gly Gly Ala Cys Ala Ala Gln Ser Ile Leu Ile His

195 200 205Asp Cys Gln Gly Leu Gln Val Lys His Cys Thr Thr Ala Val Asn Ala

210 215 220Glu Gly Ser Ser Ala Asn Asp His Leu Gly Phe Gly Gly Gly Ala Phe225 230 235 240Phe Val Thr Gly Ser Leu Ser Gly Glu Lys Ser Leu Tyr Met Pro Ala

245 250 255Gly Asp Met Val Val Ala Asn Cys Asp Gly Ala Ile Ser Phe Glu Gly

260 265 270Asn Ser Ala Asn Phe Ala Asn Gly Gly Ala Ile Ala Ala Ser Gly Lys

275 280 285Val Leu Phe Val Ala Asn Asp Lys Lys Thr Ser Phe Ile Glu Asn Arg

290 295 300Ala Leu Ser Gly Gly Ala Ile Ala Ala Ser Ser Asp Ile Ala Phe Gln305 310 315 320Asn Cys Ala Glu Leu Val Phe Lys Gly Asn Cys Ala Ile Gly Thr Glu

325 330 335Asp Lys Gly Ser Leu Gly Gly Gly Ala Ile Ser Ser Leu Gly Thr Val

340 345 350Leu Leu Gln Gly Asn His Gly Ile Thr Cys Asp Lys Asn Glu Ser Ala

355 360 365Ser Gln Gly Gly Ala Ile Phe Gly Lys Asn Cys Gln Ile Ser Asp Asn

370 375 380Glu Gly Pro Val Val Phe Arg Asp Ser Thr Ala Cys Leu Gly Gly Gly385 390 395 400Ala Ile Ala Ala Gln Glu Ile Val Ser Ile Gln Asn Asn Gln Ala Gly

405 410 415Ile Ser Phe Glu Gly Gly Lys Ala Ser Phe Gly Gly Gly Ile Ala Cys

420 425 430Gly Ser Phe Ser Ser Ala Gly Gly Ala Ser Val Leu Gly Thr Ile Asp

435 440 445Ile Ser Lys Asn Leu Gly Ala Ile Ser Phe Ser Arg Thr Leu Cys Thr

450 455 460Thr Ser Asp Leu Gly Gln Met Glu Tyr Gln Gly Gly Gly Ala Leu Phe465 470 475 480Gly Glu Asn Ile Ser Leu Ser Glu Asn Ala Gly Val Leu Thr Phe Lys

485 490 495Asp Asn Ile Val Lys Thr Phe Ala Ser Asn Gly Lys Ile Leu Gly Gly

500 505 510Gly Ala Ile Leu Ala Thr Gly Lys Val Glu Ile Thr Asn Asn Ser Gly

515 520 525Gly Ile Ser Phe Thr Gly Asn Ala Arg Ala Pro Gln Ala Leu Pro Thr

530 535 540Gln Glu Glu Phe Pro Leu Phe Ser Lys Lys Glu Gly Arg Pro Leu Ser545 550 555 560Ser Gly Tyr Ser Gly Gly Gly Ala Ile Leu Gly Arg Glu Val Ala Ile

565 570 575Leu His Asn Ala Ala Val Val Phe Glu Gln Asn Arg Leu Gln Cys Ser

580 585 590Glu Glu Glu Ala Thr Leu Leu Gly Cys Cys Gly Gly Gly Ala Val His

595 600 605Gly Met Asp Ser Thr Ser Ile Val Gly Asn Ser Ser Val Arg Phe Gly

610 615 620Asn Asn Tyr Ala Met Gly Gln Gly Val Ser Gly Gly Ala Leu Leu Ser625 630 635 640Lys Thr Val Gln Leu Ala Gly Asn Gly Ser Val Asp Phe Ser Arg Asn

645 650 655Ile Ala Ser Leu Gly Gly Gly Ala Leu Gln Ala Ser Glu Gly Asn Cys

660 665 670Glu Leu Val Asp Asn Gly Tyr Val Leu Phe Arg Asp Asn Arg Gly Arg

675 680 685Val Tyr Gly Gly Ala Ile Ser Cys Leu Arg Gly Asp Val Val Ile Ser

690 695 700Gly Asn Lys Gly Arg Val Glu Phe Lys Asp Asn Ile Ala Thr Arg Leu705 710 715 720Tyr Val Glu Glu Thr Val Glu Lys Val Glu Glu Val Glu Pro Ala Pro

725 730 735Glu Gln Lys Asp Asn Asn Glu Leu Ser Phe Leu Gly Ser Val Glu Gln

740 745 750Ser Phe Ile Thr Ala Ala Asn Gln Ala Leu Phe Ala Ser Glu Asp Gly

755 760 765Asp Leu Ser Pro Glu Ser Ser Ile Ser Ser Glu Glu Leu Ala Lys Arg

770 775 780Arg Glu Cys Ala Gly Gly Ala Ile Phe Ala Lys Arg Val Arg Ile Val785 790 795 800Asp Asn Gln Glu Ala Val Val Phe Ser Asn Asn Phe Ser Asp Ile Tyr

805 810 815Gly Gly Ala Ile Phe Thr Gly Ser Leu Arg Glu Glu Asp Lys Leu Asp

820 825 830Gly Gln Ile Pro Glu Val Leu Ile Ser Gly Asn Ala Gly Asp Val Val

835 840 845Phe Ser Gly Asn Ser Ser Lys Arg Asp Glu His Leu Pro His Thr Gly

850 855 860Gly Gly Ala Ile Cys Thr Gln Asn Leu Thr Ile Ser Gln Asn Thr Gly865 870 875 880Asn Val Leu Phe Tyr Asn Asn Val Ala Cys Ser Gly Gly Ala Val Arg

885 890 895Ile Glu Asp His Gly Asn Val Leu Leu Glu Ala Phe Gly Gly Asp Ile

900 905 910Val Phe Lys Gly Asn Ser Ser Phe Arg Ala Gln Gly Ser Asp Ala Ile

915 920 925Tyr Phe Ala Gly Lys Glu Ser His Ile Thr Ala Leu Asn Ala Thr Glu

930 935 940Gly His Ala Ile Val Phe His Asp Ala Leu Val Phe Glu Asn Leu Lys945 950 955 960Glu Arg Lys Ser Ala Glu Val Leu Leu Ile Asn Ser Arg Glu Asn Pro

965 970 975Gly Tyr Thr Gly Ser Ile Arg Phe Leu Glu Ala Glu Ser Lys Val Pro

980 985 990Gln Cys Ile His Val Gln Gln Gly Ser Leu Glu Leu Leu Asn Gly Ala

995 1000 1005Thr Leu Cys Ser Tyr Gly Phe Lys Gln Asp Ala Gly Ala Lys Leu Val

1010 1015 1020Leu Ala Ala Gly Ser Lys Leu Lys Ile Leu Asp Ser Gly Thr Pro Val1025 1030 1035 1040Gln Gly His Ala Ile Ser Lys Pro Glu Ala Glu Ile Glu Ser Ser Ser

1045 1050 1055Glu Pro Glu Gly Ala His Ser Leu Trp Ile Ala Lys Asn Ala Gln Thr

1060 1065 1070Thr Val Pro Met Val Asp Ile His Thr Ile Ser Val Asp Leu Ala Ser

1075 1080 1085Phe Ser Ser Ser Gln Gln Glu Gly Thr Val Glu Ala Pro Gln Val Ile

1090 1095 1100Val Pro Gly Gly Ser Tyr Val Arg Ser Gly Glu Leu Asn Leu Glu Leu1105 1110 1115 1120Val Asn Thr Thr Gly Thr Gly Tyr Glu Asn His Ala Leu Leu Lys Asn

1125 1130 1135Glu Ala Lys Val Pro Leu Met Ser Phe Val Ala Ser Ser Asp Glu Ala

1140 1145 1150Ser Ala Glu Ile Ser Asn Leu Ser Val Ser Asp Leu Gln Ile His Val

1155 1160 1165Ala Thr Pro Glu Ile Glu Glu Asp Thr Tyr Gly His Met Gly Asp Trp

1170 1175 1180Ser Glu Ala Lys Ile Gln Asp Gly Thr Leu Val Ile Asn Trp Asn Pro1185 1190 1195 1200Thr Gly Tyr Arg Leu Asp Pro Gln Lys Ala Gly Ala Leu Val Phe Asn

1205 1210 1215Ala Leu Trp Glu Glu Gly Ala Val Leu Ser Ala Leu Lys Asn Ala Arg

1220 1225 1230Phe Ala His Asn Leu Thr Ala Gln Arg Met Glu Phe Asp Tyr Ser Thr

1235 1240 1245Asn Val Trp Gly Phe Ala Phe Gly Gly Phe Arg Thr Leu Ser Ala Glu

1250 1255 1260Asn Leu Val Ala Ile Asp Gly Tyr Lys Gly Ala Tyr Gly Gly Ala Ser1265 1270 1275 1280Ala Gly Val Asp Ile Gln Leu Met Glu Asp Phe Val Leu Gly Val Ser

1285 1290 1295Gly Ala Ala Phe Leu Gly Lys Met Asp Ser Gln Lys Phe Asp Ala Glu

1300 1305 1310Val Ser Arg Lys Gly Val Val Gly Ser Val Tyr Thr Gly Phe Leu Ala

1315 1320 1325Gly Ser Trp Phe Phe Lys Gly Gln Tyr Ser Leu Gly Glu Thr Gln Asn

1330 1335 1340Asp Met Lys Thr Arg Tyr Gly Val Leu Gly Glu Ser Ser Ala Ser Trp1345 1350 1355 1360Thr Ser Arg Gly Val Leu Ala Asp Ala Leu Val Glu Tyr Arg Ser Leu

1365 1370 1375Val Gly Pro Val Arg Pro Thr Phe Tyr Ala Leu His Phe Asn Pro Tyr

1380 1385 1390Val Glu Val Ser Tyr Ala Ser Met Lys Phe Pro Gly Phe Thr Glu Gln

1395 1400 1405Gly Arg Glu Ala Arg Ser Phe Glu Asp Ala Ser Leu Thr Asn Ile Thr

1410 1415 1420Ile Pro Leu Gly Met Lys Phe Glu Leu Ala Phe Ile Lys Gly Gln Phe1425 1430 1435 1440Ser Glu Val Asn Ser Leu Gly Ile Ser Tyr Ala Trp Glu Ala Tyr Arg

1445 1450 1455Lys Val Glu Gly Gly Ala Val Gln Leu Leu Glu Ala Gly Phe Asp Trp

1460 1465 1470Glu Gly Ala Pro Met Asp Leu Pro Arg Gln Glu Leu Arg Val Ala Leu

1475 1480 1485Glu Asn Asn Thr Glu Trp Ser Ser Tyr Phe Ser Thr Val Leu Gly Leu

1490 1495 1500Thr Ala Phe Cys Gly Gly Phe Thr Ser Thr Asp Ser Lys Leu Gly Tyr1505 1510 1515 1520Glu Ala Asn Thr Gly Leu Arg Leu Ile Phe

1525 1530

<210>179

<211>1776

<212>PRT

<213>衣原体属

<400>179Ala Ile Met Lys Phe Met Ser Ala Thr Ala Val Phe Ala Ala Val Leu1 5 10 15Ser Ser Val Thr Glu Ala Ser Ser Ile Gln Asp Gln Ile Lys Asn Thr

20 25 30Asp Cys Asn Val Ser Lys Val Gly Tyr Ser Thr Ser Gln Ala Phe Thr

35 40 45Asp Met Met Leu Ala Asp Asn Thr Glu Tyr Arg Ala Ala Asp Ser Val

50 55 60Ser Phe Tyr Asp Phe Ser Thr Ser Ser Gly Leu Pro Arg Lys His Leu65 70 75 80Ser Ser Ser Ser Glu Ala Ser Pro Thr Thr Glu Gly Val Ser Ser Ser

85 90 95Ser Ser Gly Glu Asn Thr Glu Asn Ser Gln Asp Ser Ala Pro Ser Ser

100 105 110Gly Glu Thr Asp Lys Lys Thr Glu Glu Glu Leu Asp Asn Gly Gly Ile

115 120 125Ile Tyr Ala Arg Glu Lys Leu Thr Ile Ser Glu Ser Gln Asp Ser Leu

130 135 140Ser Asn Pro Ser Ile Glu Leu His Asp Asn Ser Phe Phe Phe Gly Glu145 150 155 l60Gly Glu Val Ile Phe Asp His Arg Val Ala Leu Lys Asn Gly Gly Ala

165 170 175Ile Tyr Gly Glu Lys Glu Val Val Phe Glu Asn Ile Lys Ser Leu Leu

180 185 190Val Glu Val Asn Ile Ser Val Glu Lys Gly Gly Ser Val Tyr Ala Lys

195 200 205Glu Ara Val Ser Leu Glu Asn Val Thr Glu Ala Thr Phe Ser Ser Asn

210 215 220Gly Gly Glu Gln Gly Gly Gly Gly Ile Tyr Ser Glu Gln Asp Met Leu225 230 235 240Ile Ser Asp Cys Asn Asn Val His Phe Gln Gly Asn Ala Ala Gly Ala

245 250 255Thr Ala Val Lys Gln Cys Leu Asp Glu Glu Met Ile Val Leu Leu Thr

260 265 270Glu Cys Val Asp Ser Leu Ser Glu Asp Thr Leu Asp Ser Thr Pro Glu

275 280 285Thr Glu Gln Thr Lys Ser Asn Gly Asn Gln Asp Gly Ser Ser Glu Thr

290 295 300Lys Asp Thr Gln Val Ser Glu Ser Pro Glu Ser Thr Pro Ser Pro Asp305 310 315 320Asp Val Leu Gly Lys Gly Gly Gly Ile Tyr Thr Glu Lys Ser Leu Thr

325 330 335Ile Thr Gly Ile Thr Gly Thr Ile Asp Phe Val Ser Asn Ile Ala Thr

340 345 350Asp Ser Gly Ala Gly Val Phe Thr Lys Glu Asn Leu Ser Cys Thr Asn

355 360 365Thr Asn Ser Leu Gln Phe Leu Lys Asn Ser Ala Gly Gln His Gly Gly

370 375 380Gly Ala Tyr Val Thr Gln Thr Met Ser Val Thr Asn Thr Thr Ser Glu385 390 395 400Ser Ile Thr Thr Pro Pro Leu Val Gly Glu Val Ile Phe Ser Glu Asn

405 410 415Thr Ala Lys Gly His Gly Gly Gly Ile Cys Thr Asn Lys Leu Ser Leu

420 425 430Ser Asn Leu Lys Thr Val Thr Leu Thr Lys Asn Ser Ala Lys Glu Ser

435 440 445Gly Gly Ala Ile Phe Thr Asp Leu Ala Ser Ile Pro Thr Thr Asp Thr

450 455 460Pro Glu Ser Ser Thr Pro Ser Ser Ser Ser Pro Ala Ser Thr Pro Glu465 470 475 480Val Val Ala Ser Ala Lys Ile Asn Arg Phe Phe Ala Ser Thr Ala Glu

485 490 495Pro Ala Ala Pro Ser Leu Thr Glu Ala Glu Ser Asp Gln Thr Asp Gln

500 505 510Thr Glu Thr Ser Asp Thr Asn Ser Asp Ile Asp Val Ser Ile Glu Asn

515 520 525Ile Leu Asn Val Ala Ile Asn Gln Asn Thr Ser Ala Lys Lys Gly Gly

530 535 540Ala Ile Tyr Gly Lys Lys Ala Lys Leu Ser Arg Ile Asn Asn Leu Glu545 550 555 560Leu Ser Gly Asn Ser Ser Gln Asp Val Gly Gly Gly Leu Cys Leu Thr

565 570 575Glu Ser Val Glu Phe Asp Ala Ile Gly Ser Leu Leu Ser His Tyr Asn

580 585 590Ser Ala Ala Lys Glu Gly Gly Val Ile His Ser Lys Thr Val Thr Leu

595 600 605Ser Asn Leu Lys Ser Thr Phe Thr Phe Ala Asp Asn Thr Val Lys Ala

610 615 620Ile Val Glu Ser Thr Pro Glu Ala Pro Glu Glu Ile Pro Pro Val Glu625 630 635 640Gly Glu Glu Ser Thr Ala Thr Glu Asn Pro Asn Ser Asn Thr Glu Gly

645 650 655Ser Ser Ala Asn Thr Asn Leu Glu Gly Ser Gln Gly Asp Thr Ala Asp

660 665 670Thr Gly Thr Gly Val Val Asn Asn Glu Ser Gln Asp Thr Ser Asp Thr

675 680 685Gly Asn Ala Glu Ser Gly Glu Gln Leu Gln Asp Ser Thr Gln Ser Asn

690 695 700Glu Glu Asn Thr Leu Pro Asn Ser Ser Ile Asp Gln Ser Asn Glu Asn705 710 715 720Thr Asp Glu Ser Ser Asp Ser His Thr Glu Glu Ile Thr Asp Glu Ser

725 730 735Val Ser Ser Ser Ser Lys Ser Gly Ser Ser Thr Pro Gln Asp Gly Gly

740 745 750Ala Ala Ser Ser Gly Ala Pro Ser Gly Asp Gln Ser Ile Ser Ala Asn

755 760 765Ala Cys Leu Ala Lys Ser Tyr Ala Ala Ser Thr Asp Ser Ser Pro Val

770 775 780Ser Asn Ser Ser Gly Ser Asp Val Thr Ala Ser Ser Asp Asn Pro Asp785 790 795 800Ser Ser Ser Ser Gly Asp Ser Ala Gly Asp Ser Glu Gly Pro Thr Glu

805 810 815Pro Glu Ala Gly Ser Thr Thr Glu Thr Pro Thr Leu Ile Gly Gly Gly

820 825 830Ala Ile Tyr Gly Glu Thr Val Lys Ile Glu Asn Phe Ser Gly Gln Gly

835 840 845Ile Phe Ser Gly Asn Lys Ala Ile Asp Asn Thr Thr Glu Gly Ser Ser

850 855 860Ser Lys Ser Asn Val Leu Gly Gly Ala Val Tyr Ala Lys Thr Leu Phe865 870 875 880Asn Leu Asp Ser Gly Ser Ser Arg Arg Thr Val Thr Phe Ser Gly Asn

885 890 895Thr Val Ser Ser Gln Ser Thr Thr Gly Gln Val Ala Gly Gly Ala Ile

900 905 910Tyr Ser Pro Thr Val Thr Ile Ala Thr Pro Val Val Phe Ser Lys Asn

915 920 925Ser Ala Thr Asn Asn Ala Asn Asn Ala Thr Asp Thr Gln Arg Lys Asp

930 935 940Thr Phe Gly Gly Ala Ile Gly Ala Thr Ser Ala Val Ser Leu Ser Gly945 950 955 960Gly Ala His Phe Leu Glu Asn Val Ala Asp Leu Gly Ser Ala Ile Gly

965 970 975Leu Val Pro Asp Thr Gln Asn Thr Glu Thr Val Lys Leu Glu Ser Gly

980 985 990Ser Tyr Tyr Phe Glu Lys Asn Lys Ala Leu Lys Arg Ala Thr Ile Tyr

995 1000 1005Ala Pro Val Val Ser Ile Lys Ala Tyr Thr Ala Thr Phe Asn Gln Asn

1010 1015 1020Arg Ser Leu Glu Glu Gly Ser Ala Ile Tyr Phe Thr Lys Glu Ala Ser1025 1030 1035 1040Ile Glu Ser Leu Gly Ser Val Leu Phe Thr Gly Asn Leu Val Thr Pro

1045 1050 1055Thr Leu Ser Thr Thr Thr Glu Gly Thr Pro Ala Thr Thr Ser Gly Asp

1060 1065 1070Val Thr Lys Tyr Gly Ala Ala Ile Phe Gly Gln Ile Ala Ser Ser Asn

1075 1080 1085Gly Ser Gln Thr Asp Asn Leu Pro Leu Lys Leu Ile Ala Ser Gly Gly

1090 1095 1100Asn Ile Cys Phe Arg Asn Asn Glu Tyr Arg Pro Thr Ser Ser Asp Thr1105 1110 1115 1120Gly Thr Ser Thr Phe Cys Ser Ile Ala Gly Asp Val Lys Leu Thr Met

1125 1130 1135Gln Ala Ala Lys Gly Lys Thr Ile Ser Phe Phe Asp Ala Ile Arg Thr

1140 1145 1150Ser Thr Lys Lys Thr Gly Thr Gln Ala Thr Ala Tyr Asp Thr Leu Asp

1155 1160 1165Ile Asn Lys Ser Glu Asp Ser Glu Thr Val Asn Ser Ala Phe Thr Gly

1170 1175 1180Thr Ile Leu Phe Ser Ser Glu Leu His Glu Asn Lys Ser Tyr Ile Pro1185 1190 1195 1200Gln Asn Val Val Leu His Ser Gly Ser Leu Val Leu Lys Pro Asn Thr

1205 1210 1215Glu Leu His Val Ile Ser Phe Glu Gln Lys Glu Gly Ser Ser Leu Val

1220 1225 1230Met Thr Pro Gly Ser Val Leu Ser Asn Gln Thr Val Ala Asp Gly Ala

1235 1240 1245Leu Val Ile Asn Asn Met Thr Ile Asp Leu Ser Ser Val Glu Lys Asn

1250 1255 1260Gly Ile Ala Glu Gly Asn Ile Phe Thr Pro Pro Glu Leu Arg Ile Ile1265 1270 1275 1280Asp Thr Thr Thr Ser Gly Ser Gly Gly Thr Pro Ser Thr Asp Ser Glu

1285 1290 1295Ser Asn Gln Asn Ser Asp Asp Thr Lys Glu Gln Asn Asn Asn Asp Ala

1300 1305 1310Ser Asn Gln Gly Glu Ser Ala Asn Gly Ser Ser Ser Pro Ala Val Ala

1315 1320 1325Ala Ala His Thr Ser Arg Thr Arg Asn Phe Ala Ala Ala Ala Thr Ala

1330 1335 1340Thr Pro Thr Thr Thr Pro Thr Ala Thr Thr Thr Thr Ser Asn Gln Val1345 1350 1355 1360Ile Leu Gly Gly Glu Ile Lys Leu Ile Asp Pro Asn Gly Thr Phe Phe

1365 1370 1375Gln Asn Pro Ala Leu Arg Ser Asp Gln Gln Ile Ser Leu Leu Val Leu

1380 1385 1390Pro Thr Asp Ser Ser Lys Met Gln Ala Gln Lys Ile Val Leu Thr Gly

1395 1400 1405Asp Ile Ala Pro Gln Lys Gly Tyr Thr Gly Thr Leu Thr Leu Asp Pro

1410 1415 1420Asp Gln Leu Gln Asn Gly Thr Ile Ser Ala Leu Trp Lys Phe Asp Ser1425 1430 1435 l440Tyr Arg Gln Trp Ala Tyr Val Pro Arg Asp Asn His Phe Tyr Ala Asn

1445 1450 1455Ser Ile Leu Gly Ser Gln Met Ser Met Val Thr Val Lys Gln Gly Leu

1460 1465 1470Leu Asn Asp Lys Met Asn Leu Ala Arg Phe Asp Glu Val Ser Tyr Asn

1475 1480 1485Asn Leu Trp Ile Ser Gly Leu Gly Thr Met Leu Ser Gln Val Gly Thr

l490 1495 1500Pro Thr Ser Glu Glu Phe Thr Tyr Tyr Ser Arg Gly Ala Ser Val Ala1505 1510 1515 1520Leu Asp Ala Lys Pro Ala His Asp Val Ile Val Gly Ala Ala Phe Ser

1525 1530 1535Lys Met Ile Gly Lys Thr Lys Ser Leu Lys Arg Glu Asn Asn Tyr Thr

1540 1545 1550His Lys Gly Ser Glu Tyr Ser Tyr Gln Ala Ser Val Tyr Gly Gly Lys

1555 1560 1565Pro Phe His Phe Val Ile Asn Lys Lys Thr Glu Lys Ser Leu Pro Leu

1570 1575 1580Leu Leu Gln Gly Val Ile Ser Tyr Gly Tyr Ile Lys His Asp Thr Val1585 1590 1595 1600Thr His Tyr Pro Thr Ile Arg Glu Arg Asn Gln Gly Glu Trp Glu Asp

1605 1610 1615Leu Gly Trp Leu Thr Ala Leu Arg Val Ser Ser Val Leu Arg Thr Pro

1620 1625 1630Ala Gln Gly Asp Thr Lys Arg Ile Thr Val Tyr Gly Glu Leu Glu Tyr

l635 1640 1645Ser Ser Ile Arg Gln Lys Gln Phe Thr Glu Thr Glu Tyr Asp Pro Arg

1650 1655 1660Tyr Phe Asp Asn Cys Thr Tyr Arg Asn Leu Ala Ile Pro Met Gly Leu1665 1670 1675 1680Ala Phe Glu Gly Glu Leu Ser Gly Asn Asp Ile Leu Met Tyr Asn Arg

1685 1690 l695Phe Ser Val Ala Tyr Met Pro Ser Ile Tyr Arg Asn Ser Pro Thr Cys

1700 1705 17l0Lys Tyr Gln Val Leu Ser Ser Gly Glu Gly Gly Glu Ile Ile Cys Gly

1715 1720 1725Val Pro Thr Arg Asn Ser Ala Arg Gly Glu Tyr Ser Thr Gln Leu Tyr

1730 1735 1740Pro Gly Pro Leu Trp Thr Leu Tyr Gly Ser Tyr Thr Ile Glu Ala Asp1745 1750 1755 1760Ala His Thr Leu Ala His Met Met Asn Cys Gly Ala Arg Met Thr Phe

1765 1770 1775

<2l0>180

<211>1752

<212>PRT

<213>衣原体属

<400>180Met Lys Trp Leu Ser Ala Thr Ala Val Phe Ala Ala Val Leu Pro Ser1 5 10 15Val Ser Gly Phe Cys Phe Pro Glu Pro Lys Glu Leu Asn Phe Ser Arg

20 25 30Val Glu Thr Ser Ser Ser Thr Thr Phe Thr Glu Thr Ile Gly Glu Ala

35 40 45Gly Ala Glu Tyr Ile Val Ser Gly Asn Ala Ser Phe Thr Lys Phe Thr

50 55 60Asn Ile Pro Thr Thr Asp Thr Thr Thr Pro Thr Asn Ser Asn Ser Ser65 70 75 80Ser Ser Ser Gly Glu Thr Ala Ser Val Ser Glu Asp Ser Asp Ser Thr

85 90 95Thr Thr Thr Pro Asp Pro Lys Gly Gly Gly Ala Phe Tyr Asn Ala His

100 105 110Ser Gly Val Leu Ser Phe Met Thr Arg Ser Gly Thr Glu Gly Ser Leu

115 120 125Thr Leu Ser Glu Ile Lys Met Thr Gly Glu Gly Gly Ala Ile Phe Ser

130 135 140Gln Gly Glu Leu Leu Phe Thr Asp Leu Thr Ser Leu Thr Ile Gln Asn145 150 155 160Asn Leu Ser Gln Leu Ser Gly Gly Ala Ile Phe Gly Gly Ser Thr Ile

165 170 175Ser Leu Ser Gly Ile Thr Lys Ala Thr Phe Ser Cys Asn Ser Ala Glu

180 185 190Val Pro Ala Pro Val Lys Lys Pro Thr Glu Pro Lys Ala Gln Thr Ala

195 200 205Ser Glu Thr Ser Gly Ser Ser Ser Ser Ser Gly Asn Asp Ser Val Ser

210 215 220Ser Pro Ser Ser Ser Arg Ala Glu Pro Ala Ala Ala Asn Leu Gln Ser225 230 235 240His Phe Ile Cys Ala Thr Ala Thr Pro Ala Ala Gln Thr Asp Thr Glu

245 250 255Thr Ser Thr Pro Ser His Lys Pro Gly Ser Gly Gly Ala Ile Tyr Ala

260 265 270Lys Gly Asp Leu Thr Ile Ala Asp Ser Gln Glu Val Leu Phe Ser Ile

275 280 285Asn Lys Ala Thr Lys Asp Gly Gly Ala Ile Phe Ala Glu Lys Asp Val

290 295 300Ser Phe Glu Asn Ile Thr Ser Leu Lys Val Gln Thr Asn Gly Ala Glu305 310 315 320Glu Lys Gly Gly Ala Ile Tyr Ala Lys Gly Asp Leu Ser Ile Gln Ser

325 330 335Ser Lys Gln Ser Leu Phe Asn Ser Asn Tyr Ser Lys Gln Gly Gly Gly

340 345 350Ala Leu Tyr Val Glu Gly Gly Ile Asn Phe Gln Asp Leu Glu Glu Ile

355 360 365Arg Ile Lys Tyr Asn Lys Ala Gly Thr Phe Glu Thr Lys Lys Ile Thr

370 375 380Leu Pro Ser Leu Lys Ala Gln Ala Ser Ala Gly Asn Ala Asp Ala Trp385 390 395 400Ala Ser Ser Ser Pro Gln Ser Gly Ser Gly Ala Thr Thr Val Ser Asp

405 410 415Ser Gly Asp Ser Ser Ser Gly Ser Asp Ser Asp Thr Ser Glu Thr Val

420 425 430Pro Val Thr Ala Lys Gly Gly Gly Leu Tyr Thr Asp Lys Asn Leu Ser

435 440 445Ile Thr Asn Ile Thr Gly Ile Ile Glu Ile Ala Asn Asn Lys Ala Thr

450 455 460Asp Val Gly Gly Gly Ala Tyr Val Lys Gly Thr Leu Thr Cys Glu Asn465 470 475 480Ser His Arg Leu Gln Phe Leu Lys Asn Ser Ser Asp Lys Gln Gly Gly

485 490 495Gly Ile Tyr Gly Glu Asp Asn Ile Thr Leu Ser Asn Leu Thr Gly Lys

500 505 510Thr Leu Phe Gln Glu Asn Thr Ala Lys Glu Glu Gly Gly Gly Leu Phe

515 520 525Ile Lys Gly Thr Asp Lys Ala Leu Thr Met Thr Gly Leu Asp Ser Phe

530 535 540Cys Leu Ile Asn Asn Thr Ser Glu Lys His Gly Gly Gly Ala Phe Val545 550 555 560Thr Lys Glu Ile Ser Gln Thr Tyr Thr Ser Asp Val Glu Thr Ile Pro

565 570 575Gly Ile Thr Pro Val His Gly Glu Thr Val Ile Thr Gly Asn Lys Ser

580 585 590Thr Gly Gly Asn Gly Gly Gly Val Cys Thr Lys Arg Leu Ala Leu Ser

595 600 605Asn Leu Gln Ser Ile Ser Ile Ser Gly Asn Ser Ala Ala Glu Asn Gly

610 615 620Gly Gly Ala His Thr Cys Pro Asp Ser Phe Pro Thr Ala Asp Thr Ala625 630 635 640Glu Gln Pro Ala Ala Ala Ser Ala Ala Thr Ser Thr Pro Lys Ser Ala

645 650 655Pro Val Ser Thr Ala Leu Ser Thr Pro Ser Ser Ser Thr Val Ser Ser

660 665 670Leu Thr Leu Leu Ala Ala Ser Ser Gln Ala Ser Pro Ala Thr Ser Asn

675 680 685Lys Glu Thr Gln Asp Pro Asn Ala Asp Thr Asp Leu Leu Ile Asp Tyr

690 695 700Val Val Asp Thr Thr Ile ser Lys Asn Thr Ala Lys Lys Gly Gly Gly705 710 715 720Ile Tyr Ala Lys Lys Ala Lys Met Ser Arg Ile Asp Gln Leu Asn Ile

725 730 735Ser Glu Asn Ser Ala Thr Glu Ile Gly Gly Gly Ile Cys Cys Lys Glu

740 745 750Ser Leu Glu Leu Asp Ala Leu Val Ser Leu Ser Val Thr Glu Asn Leu

755 760 765Val Gly Lys Glu Gly Gly Gly Leu His Ala Lys Thr Val Asn Ile Ser

770 775 780Asn Leu Lys Ser Gly Phe Ser Phe Ser Asn Asn Lys Ala Asn Ser Ser785 790 795 800Ser Thr Gly Val Ala Thr Thr Ala Ser Ala Pro Ala Ala Ala Ala Ala

805 810 815Ser Leu Gln Ala Ala Ala Ala Ala Ala Pro Ser Ser Pro Ala Thr Pro

820 825 830Thr Tyr Ser Gly Val Val Gly Gly Ala Ile Tyr Gly Glu Lys Val Thr

835 840 845Phe Ser Gln Cys Ser Gly Thr Cys Gln Phe Ser Gly Asn Gln Ala Ile

850 855 860Asp Asn Asn Pro Ser Gln Ser Ser Leu Asn Val Gln Gly Gly Ala Ile865 870 875 880Tyr Ala Lys Thr Ser Leu Ser Ile Gly Ser Ser Asp Ala Gly Thr Ser

885 890 895Tyr Ile Phe Ser Gly Asn Ser Val Ser Thr Gly Lys Ser Gln Thr Thr

900 905 910Gly Gln Ile Ala Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr Leu Asn

915 920 925Cys Pro Ala Thr Phe Ser Asn Asn Thr Ala Ser Ile Ala Thr Pro Lys

930 935 940Thr Ser Ser Glu Asp Gly Ser Ser Gly Asn Ser Ile Lys Asp Thr Ile945 950 955 960Gly Gly Ala Ile Ala Gly Thr Ala Ile Thr Leu ser Gly yal Ser Arg

965 970 975Phe Ser Gly Asn Thr Ala Asp Leu Gly Ala Ala Ile Gly Thr Leu Ala

980 985 990Asn Ala Asn Thr Pro Ser Ala Thr Ser Gly Ser Gln Asn Ser Ile Thr

995 1000 1005Glu Lys Ile Thr Leu Glu Asn Gly Ser Phe Ile Phe Glu Arg Asn Gln

1010 1015 1020Ala Asn Lys Arg Gly Ala Ile Tyr Ser Pro Ser Val Ser Ile Lys Gly1025 1030 1035 1040Asn Asn Ile Thr Phe Asn Gln Asn Thr Ser Thr His Asp Gly Ser Ala

1045 1050 1055Ile Tyr Phe Thr Lys Asp Ala Thr Ile Glu Ser Leu Gly Ser Val Leu

1060 1065 1070Phe Thr Gly Asn Asn Val Thr Ala Thr Gln Ala Ser Ser Ala Thr Ser

1075 1080 1085Gly Gln Asn Thr Asn Thr Ala Asn Tyr Gly Ala Ala Ile Phe Gly Asp

1090 1095 1100Pro Gly Thr Thr Gln Ser Ser Gln Thr Asp Ala Ile Leu Thr Leu Leu1105 1110 1115 1120Ala Ser Ser Gly Asn Ile Thr Phe Ser Asn Asn Ser Leu Gln Asn Asn

1125 1130 1135Gln Gly Asp Thr Pro Ala Ser Lys Phe Cys Ser Ile Ala Gly Tyr Val

1140 1145 1150Lys Leu Ser Leu Gln Ala Ala Lys Gly Lys Thr Ile Ser Phe Phe Asp

1155 1160 1165Cys Val His Thr Ser Thr Lys Lys Thr Gly Ser Thr Gln Asn Val Tyr

1170 1175 1180Glu Thr Leu Asp Ile Asn Lys Glu Glu Asn Ser Asn Pro Tyr Thr Gly1185 1190 1195 1200Thr Ile Val Phe Ser Ser Glu Leu His Glu Asn Lys Ser Tyr Ile Pro

1205 1210 1215Gln Asn Ala Ile Leu His Asn Gly Thr Leu Val Leu Lys Glu Lys Thr

1220 1225 1230Glu Leu His Val Val Ser Phe Glu Gln Lys Glu Gly Ser Lys Leu Ile

1235 1240 1245Met Glu Pro Gly Ala Val Leu Ser Asn Gln Asn Ile Ala Asn Gly Ala

1250 1255 1260Leu Ala Ile Asn Gly Leu Thr Ile Asp Leu Ser Ser Met Gly Thr Pro1265 1270 1275 1280Gln Ala Gly Glu Ile Phe Ser Pro Pro Glu Leu Arg Ile Val Ala Thr

1285 1290 1295Thr Ser Ser Ala Ser Gly Gly Ser Gly Val Ser Ser Ser Ile Pro Thr

1300 1305 1310Asn Pro Lys Arg Ile Ser Ala Ala Val Pro Ser Gly Ser Ala Ala Thr

1315 1320 1325Thr Pro Thr Met Ser Glu Asn Lys Val Phe Leu Thr Gly Asp Leu Thr

1330 1335 1340Leu Ile Asp Pro Asn Gly Asn Phe Tyr Gln Asn Pro Met Leu Gly Ser1345 1350 1355 1360Asp Leu Asp Val Pro Leu Ile Lys Leu Pro Thr Asn Thr Ser Asp Val

1365 1370 1375Gln Val Tyr Asp Leu Thr Leu Ser Gly Asp Leu Phe Pro Gln Lys Gly

1380 1385 1390Tyr Met Gly Thr Trp Thr Leu Asp Ser Asn Pro Gln Thr Gly Lys Leu

1395 1400 1405Gln Ala Arg Trp Thr Phe Asp Thr Tyr Arg Arg Trp Val Tyr Ile Pro

1410 1415 1420Arg Asp Asn His Phe Tyr Ala Asn Ser Ile Leu Gly Ser Gln Asn Ser1425 1430 1435 1440Met Ile Val Val Lys Gln Gly Leu Ile Asn Asn Met Leu Asn Asn Ala

1445 1450 1455Arg Phe Asp Asp Ile Ala Tyr Asn Asn Phe Trp Val Ser Gly Val Gly

1460 1465 1470Thr Phe Leu Ala Gln Gln Gly Thr Pro Leu Ser Glu Glu Phe Ser Tyr

1475 1480 1485Tyr Ser Arg Gly Thr Ser Val Ala Ile Asp Ala Lys Pro Arg Gln Asp

1490 1495 1500Phe Ile Leu Gly Ala Ala Phe Ser Lys Ile Val Gly Lys Thr Lys Ala1505 1510 1515 1520Ile Lys Lys Met His Asn Tyr Phe His Lys Gly Ser Glu Tyr Ser Tyr

1525 1530 1535Gln Ala Ser Val Tyr Gly Gly Lys Phe Leu Tyr Phe Leu Leu Asn Lys

1540 1545 1550Gln His Gly Trp Ala Leu Pro Phe Leu Ile Gln Gly Val Val Ser Tyr

1555 1560 1565Gly His Ile Lys His Asp Thr Thr Thr Leu Tyr Pro Ser Ile His Glu

1570 1575 1580Arg Asn Lys Gly Asp Trp Glu Asp Leu Gly Trp Leu Ala Asp Leu Arg1585 1590 1595 1600Ile Ser Met Asp Leu Lys Glu Pro Ser Lys Asp Ser Ser Lys Arg Ile

1605 1610 1615Thr Val Tyr Gly Glu Leu Glu Tyr Ser Ser Ile Arg Gln Lys Gln Phe

1620 1625 1630Thr Glu Ile Asp Tyr Asp Pro Arg His Phe Asp Asp Cys Ala Tyr Arg

1635 1640 1645Asn Leu Ser Leu Pro Val Gly Cys Ala Val Glu Gly Ala Ile Met Asn

1650 1655 1660Cys Asn Ile Leu Met Tyr Asn Lys Leu Ala Leu Ala Tyr Met Pro Ser1665 1670 1675 1680Ile Tyr Arg Asn Asn Pro Val Cys Lys Tyr Arg Val Leu Ser Ser Asn

1685 1690 1695Glu Ala Gly Gln Val Ile Cys Gly Val Pro Thr Arg Thr Ser Ala Arg

1700 1705 1710Ala Glu Tyr Ser Thr Gln Leu Tyr Leu Gly Pro Phe Trp Thr Leu Tyr

1715 1720 1725Gly Asn Tyr Thr Ile Asp Val Gly Met Tyr Thr Leu Ser Gln Met Thr

1730 1735 1740Ser Cys Gly Ala Arg Met Ile Phe1745 1750

<210>181

<211>2601

<212>DNA

<213>衣原体属

<400>181atggctagcc atcaccatca ccatcacctc tttggccagg atcccttagg tgaaaccgcc 60ctcctcacta aaaatcctaa tcatgtcgtc tgtacatttt ttgaggactg taccatggag 120agcctctttc ctgctctttg tgctcatgca tcacaagacg atcctttgta tgtacttgga 180aattcctact gttggttcgt atctaaactc catatcacgg accccaaaga ggctcttttt 240aaagaaaaag gagatctttc cattcaaaac tttcgcttcc tttccttcac agattgctct 300tccaaggaaa gctctccttc tattattcat caaaagaatg gtcagttatc cttgcgcaat 360aatggtagca tgagtttctg tcgaaatcat gctgaaggct ctggaggagc catctctgcg 420gatgcctttt ctctacagca caactatctt ttcacagctt ttgaagagaa ttcttctaaa 480ggaaatggcg gagccattca ggctcaaacc ttctctttat ctagaaatgt gtcgcctatt 540tctttcgccc gtaatcgtgc ggatttaaat ggcggcgcta tttgctgtag taatcttatt 600tgttcaggga atgtaaaccc tctctttttc actggaaact ccgccacraa tggaggcsct 660atttgttgta tcagcgatct aaacacctca gaaaaaggct ctctctctct tgcttgtaac 720caaraaacgc tatttgcaag caattctgct aaagaaaaag gcggggctat ttatgccaag 780cacatggtat tgcgttataa cggtcctgtt tccttcatta acaacagcgc taaaataggt 840ggagctatcg ccatccagtc cggagggagt ctctctatcc ttgcaggtga aggatctgtt 900ctgttccaga ataactccca acgcacctcc gaccaaggtc tagtaagaaa cgccatctac 960ttagagaaag atgcgattct ttcttcctta gaagctcgca acggagatat tcttttcttt 1020gatcctattg tacaagaaag tagcagcaaa gaatcgcctc ttccctcctc tttgcaagcc 1080agcgtgactt ctcccacccc agccaccgca tctcctttag ttattcagac aagtgcaaac 1140cgttcagtga ttttctcgag cgaacgtctt tctgaagaag aaaaaactcc tgataacctc 1200acttcccaac tacagcagcc tatcgaactg aaatccggac gcttagtttt aaaagatcgc 1260gctgtccttt ccgsgccttc tctctctcag gatcctcaag ctctcctcat tatggaagcg 1320ggaacttctt taaaaacttc ctytgatttg aagttagsta cgstaagtat tccccttcat 1380tccttagata ctgaaaaaag cgtaactatc cacgccccta atctttctat ccaaaagatc 1440ttcctctcta actctggaga tgagaatttt tatgaaaatg tagagcttct cagtaaagag 1500caaaacaata ttcctctcct tactctccct aaagagcaat ctcatttaca tcttcctgat 1560gggaacctct cttctcactt tggatatcaa ggagattgga ctttttcttg gaaagattct 1620gatgaagggc attctctgat tgctaattgg acgcctaaaa actatgtgcc tcatccagaa 1680cgtcaatcta cactcgttgc gaacactctt tggaacacct attccgatat gcaagctgtg 1740cagtcgatga ttaatacaac agcgcacgga ggagcctatc tatttggaac gtggggatct 1800gctgtttcta atttattcta tgttcacgac agctctggga aacctatcga taattggcat 1860catagaagcc ttggctacct attcggtatc agtactcaca gtttagatga ccattctttc 1920tgcttggctg caggacaatt actcgggaaa tcgtccgatt cctttattac gtctacagaa 1980acgacctcct atatagctac tgtacaagcg caactcgcta cctctctaat gaaaatctct 2040gcacaggcat gctacaatga aagtatccat gagctaaaaa caaaatatcg ctccttctct 2100aaagaaggat tcggatcctg gcatagcgtt gcagtatccg gagaagtgtg cgcatcgatt 2160cctattgtat ccaatggttc cggactgttc agctccttct ctattttctc taaactgcaa 2220ggattttcag gaacacagga cggttttgag gagagttcgg gagagattcg gtccttttct 2280gccagctctt tcagaaatat ttcacttcct ataggaataa catttgaaaa aaaatcccaa 2340aaaacacgaa cctactatta ctttctagga gcctacatcc aagacctgaa acgtgatgtg 2400gaatcgggac ctgtagtgtt actcaaaaat gccgtctcct gggatgctcc tatggcgaac 2460ttggattcac gagcctacat gttccggctt acgaatcaaa gagctctaca cagacttcag 2520acgctgttaa atgtgtcttg tgtgctgcgt gggcaaagcc atagttactc cctggatctg 2580gggaccactt acaggttcta g 2601

<210>182

<211>3021

<212>DNA

<213>衣原体属

<400>182atggctagca tgactggtgg acagcaaatg ggtcgggatt caagcttggt accgcatcac 60catcaccatc acatgattcc tcaaggaatt tacgatgggg agacgttaac tgtatcattt 120ccctatactg ttataggaga tccgagtggg actactgttt tttctgcagg agagttaaca 180ttaaaaaatc ttgacaattc tattgcagct ttgcctttaa gttgttttgg gaacttatta 240gggagtttta ctgttttagg gagaggacac tcgttgactt tcgagaacat acggacttct 300acaaatgggg cagctctaag taatagcgct gctgatggac tgtttactat tgagggtttt 360aaagaattat ccttttccaa ttgcaattca ttacttgccg tactgcctgc tgcaacgact 420aataagggta gccagactcc gacgacaaca tctacaccgt ctaatggtac tatttattct 480aaaacagatc ttttgttact caataatgag aagttctcat tctatagtaa tttagtctct 540ggagatgggg gagctataga tgctaagagc ttaacggttc aaggaattag caagctttgt 600gtcttccaag aaaatactgc tcaagctgat gggggagctt gtcaagtagt caccagtttc 660tctgctatgg ctaacgaggc tcctattgcc tttgtagcga atgttgcagg agtaagaggg 720ggagggattg ctgctgttca ggatgggcag cagggagtgt catcatctac ttcaacagaa 780gatccagtag taagtttttc cagaaatact gcggtagagt ttgatgggaa cgtagcccga 840gtaggaggag ggatttactc ctacgggaac gttgctttcc tgaataatgg aaaaaccttg 900tttctcaaca atgttgcttc tcctgtttac attgctgcta agcaaccaac aagtggacag 960gcttctaata cgagtaataa ttacggagat ggaggagcta tcttctgtaa gaatggtgcg 1020caagcaggat ccaataactc tggatcagtt tcctttgatg gagagggagt agttttcttt 1080agtagcaatg tagctgctgg gaaaggggga gctatttatg ccaaaaagct ctcggttgct 1140aactgtggcc ctgtacaatt tttaaggaat atcgctaatg atggtggagc gatttattta 1200ggagaatctg gagagctcag tttatctgct gattatggag atattatttt cgatgggaat 1260cttaaaagaa cagccaaaga gaatgctgcc gatgttaatg gcgtaactgt gtcctcacaa 1320gccatttcga tgggatcggg agggaaaata acgacattaa gagctaaagc agggcatcag 1380attctcttta atgatcccat cgagatggca aacggaaata accagccagc gcagtcttcc 1440aaacttctaa aaattaacga tggtgaagga tacacagggg atattgtttt tgctaatgga 1500agcagtactt tgtaccaaaa tgttacgata gagcaaggaa ggattgttct tcgtgaaaag 1560gcaaaattat cagtgaattc tctaagtcag acaggtggga gtctgtatat ggaagctggg 1620agtacattgg attttgtaac tccacaacca ccacaacagc ctcctgccgc taatcagttg 1680atcacgcttt ccaatctgca tttgtctctt tcttctttgt tagcaaacaa tgcagttacg 1740aatcctccta ccaatcctcc agcgcaagat tctcatcctg cagtcattgg tagcacaact 1800gctggttctg ttacaattag tgggcctatc ttttttgagg atttggatga tacagcttat 1860gataggtatg attggctagg ttctaatcaa aaaatcaatg tcctgaaatt acagttaggg 1920actaagcccc cagctaatgc cccatcagat ttgactctag ggaatgagat gcctaagtat 1980ggctatcaag gaagctggaa gcttgcgtgg gatcctaata cagcaaataa tggtccttat 2040actctgaaag ctacatggac taaaactggg tataatcctg ggcctgagcg agtagcttct 2100ttggttccaa atagtttatg gggatccatt ttagatatac gatctgcgca ttcagcaatt 2160caagcaagtg tggatgggcg ctcttattgt cgaggattat gggtttctgg agtttcgaat 2220ttcttctatc atgaccgcga tgctttaggt cagggatatc ggtatattag tgggggttat 2280tccttaggag caaactccta ctttggatca tcgatgtttg gtctagcatt taccgaagta 2340tttggtagat ctaaagatta tgtagtgtgt cgttccaatc atcatgcttg cataggatcc 2400gtttatctat ctacccaaca agctttatgt ggatcctatt tgttcggaga tgcgtttatc 2460cgtgctagct acgggtttgg gaatcagcat atgaaaacct catatacatt tgcagaggag 2520agcgatgttc gttgggataa taactgtctg gctggagaga ttggagcggg attaccgatt 2580gtgattactc catctaagct ctatttgaat gagttgcgtc ctttcgtgca agctgagttt 2640tcttatgccg atcatgaatc ttttacagag gaaggcgatc aagctcgggc attcaagagc 2700ggacatctcc taaatctatc agttcctgtt ggagtgaagt ttgatcgatg ttctagtaca 2760catcctaata aatatagctt tatggcggct tatatctgtg atgcttatcg caccatctct 2820ggtactgaga caacgctcct atcccatcaa gagacatgga caacagatgc ctttcattta 2880gcaagacatg gagttgtggt tagaggatct atgtatgctt ctctaacaag taatatagaa 2940gtatatggcc atggaagata tgagtatcga gatgcttctc gaggctatgg tttgagtgca 3000ggaagtaaag tccggttcta a 3021

<210>183

<211>2934

<212>DNA

<213>衣原体属

<400>183atggctagca tgactggtgg acagcaaatg ggtcgggatt caagcttggt accgagctcg 60gatccacatc accatcacca tcacggacta gctagagagg ttccttctag aatctttctt 120atgcccaact cagttccaga tcctacgaaa gagtcgctat caaataaaat tagtttgaca 180ggagacactc acaatctcac taactgctat ctcgataacc tacgctacat actggctatt 240ctacaaaaaa ctcccaatga aggagctgct gtcacaataa cagattacct aagctttttt 300gatacacaaa aagaaggtat ttattttgca aaaaatctca cccctgaaag tggtggtgcg 360attggttatg cgagtcccaa ttctcctacc gtggagattc gtgatacaat aggtcctgta 420atctttgaaa ataatacttg ttgcagacta tttacatgga gaaatcctta tgctgctgat 480aaaataagag aaggcggagc cattcatgct caaaatcttt acataaatca taatcatgat 540gtggtcggat ttatgaagaa cttttcttat gtccaaggag gagccattag taccgctaat 600acctttgttg tgagcgagaa tcagtcttgt tttctcttta tggacaacat ctgtattcaa 660actaatacag caggaaaagg tggcgctatc tatgctggaa cgagcaattc ttttgagagt 720aataactgcg atctcttctt catcaataac gcctgttgtg caggaggagc gatcttctcc 780cctatctgtt ctctaacagg aaatcgtggt aacatcgttt tctataacaa tcgctgcttt 840aaaaatgtag aaacagcttc ttcagaagct tctgatggag gagcaattaa agtaactact 900cgcctagatg ttacaggcaa tcgtggtagg atctttttta gtgacaatat cacaaaaaat 960tatggcggag ctatttacgc tcctgtagtt accctagtgg ataatggccc tacctacttt 1020ataaacaata tcgccaataa taaggggggc gctatctata tagacggaac cagtaactcc 1080aaaatttctg ccgaccgcca tgctattatt tttaatgaaa atattgtgac taatgtaact 1140aatgcaaatg gtaccagtac gtcagctaat cctcctagaa gaaatgcaat aacagtagca 1200agctcctctg gtgaaattct attaggagca gggagtagcc aaaatttaat tttttatgat 1260cctattgaag ttagcaatgc aggggtctct gtgtccttca ataaggaagc tgatcaaaca 1320ggctctgtag tattttcagg agctactgtt aattctgcag attttcatca acgcaattta 1380caaacaaaaa cacctgcacc ccttactctc agtaatggtt ttctatgtat cgaagatcat 1440gctcagctta cagtgaatcg attcacacaa actgggggtg ttgtttctct tgggaatgga 1500gcagttctga gttgctataa aaatggtaca ggagattctg ctagcaatgc ctctataaca 1560ctgaagcata ttggattgaa tctttcttcc attctgaaaa gtggtgctga gattccttta 1620ttgtgggtag agcctacaaa taacagcaat aactatacag cagatactgc agctaccttt 1680tcattaagtg atgtaaaact ctcactcatt gatgactacg ggaactctcc ttatgaatcc 1740acagatctga cccatgctct gtcatcacag cctatgctat ctatttctga agctagcgat 1800aaccagctac aatcagaaaa tatagatttt tcgggactaa atgtccctca ttatggatgg 1860caaggacttt ggacttgggg ctgggcaaaa actcaagatc cagaaccagc atcttcagca 1920acaatcactg atccacaaaa agccaataga tttcatagaa ccttactact aacatggctt 1980cctgccgggt atgttcctag cccaaaacac agaagtcccc tcatagctaa caccttatgg 2040gggaatatgc tgcttgcaac agaaagctta aaaaatagtg cagagctgac acctagtggt 2100catcctttct ggggaattac aggaggagga ctaggcatga tggtttacca agatcctcga 2160gaaaatcatc ctggattcca tatgcgctct tccggatact ctgcggggat gatagcaggg 2220cagacacaca ccttctcatt gaaattcagt cagacctaca ccaaactcaa tgagcgttac 2280gcaaaaaaca acgtatcttc taaaaattac tcatgccaag gagaaatgct cttctcattg 2340caagaaggtt tcttgctgac taaattagtt gggctttaca gctatggaga ccataactgt 2400caccatttct atactcaagg agaaaatcta acatctcaag ggacgttccg cagtcaaacg 2460atgggaggtg ctgtcttttt tgatctccct atgaaaccct ttggatcaac gcatatactg 2520acagctccct ttttaggtgc tcttggtatt tattctagcc tgtctcactt tactgaggtg 2580ggagcctatc cgcgaagctt ttctacaaag actcctttga tcaatgtcct agtccctatt 2640ggagttaaag gtagctttat gaatgctacc cacagacctc aagcctggac tgtagaattg 2700gcataccaac ccgttctgta tagacaagaa ccagggatcg cgacccagct cctagccagt 2760aaaggtattt ggtttggtag tggaagcccc tcatcgcgtc atgccatgtc ctataaaatc 2820tcacagcaaa cacaaccttt gagttggtta actctccatt tccagtatca tggattctac 2880tcctcttcaa ccttctgtaa ttatctcaat ggggaaattg ctctgcgatt ctag 2934

<210>184

<211>2547

<212>DNA

<213>衣原体属

<400>184atggctagcc atcaccatca ccatcacggt gctatttctt gcttacgtgg agatgtagtc 60atttctggaa acaagggtag agttgaattt aaagacaaca tagcaacacg tctttatgtg 120gaagaaactg tagaaaaggt tgaagaggta gagccagctc ctgagcaaaa agacaataat 180gagctttctt tcttagggag tgtagaacag agttttatta ctgcagctaa tcaagctctt 240ttcgcatctg aagatgggga tttatcacct gagtcatcca tttcttctga agaacttgcg 300aaaagaagag agtgtgctgg aggagctatt tttgcaaaac gggttcgtat tgtagataac 360caagaggccg ttgtattctc gaataacttc tctgatattt atggcggcgc catttttaca 420ggttctcttc gagaagagga taagttagat gggcaaatcc ctgaagtctt gatctcaggc 480aatgcagggg atgttgtttt ttccggaaat tcctcgaagc gtgatgagca tcttcctcat 540acaggtgggg gagccatttg tactcaaaat ttgacgattt ctcagaatac agggaatgtt 600ctgttttata acaacgtggc ctgttcggga ggagctgttc gtatagagga tcatggtaat 660gttcttttag aagcttttgg aggagatatt gtttttaaag gaaattcttc tttcagagca 720caaggatccg atgctatcta ttttgcaggt aaagaatcgc atattacagc cctgaatgct 780acggaaggac atgctattgt tttccacgac gcattagttt ttgaaaatct aaaagaaagg 840aaatctgctg aagtattgtt aatcaatagt cgagaaaatc caggttacac tggatctatt 900cgatttttag aagcagaaag taaagttcct caatgtattc atgtacaaca aggaagcctt 960gagttgctaa atggagctac attatgtagt tatggtttta aacaagatgc tggagctaag 1020ttggtattgg ctgctggatc taaactgaag attttagatt caggaactcc tgtacaaggg 1080catgctatca gtaaacctga agcagaaatc gagtcatctt ctgaaccaga gggtgcacat 1140tctctttgga ttgcgaagaa tgctcaaaca acagttccta tggttgatat ccatactatt 1200tctgtagatt tagcctcctt ctcttctagt caacaggagg ggacagtaga agctcctcag 1260gttattgttc ctggaggaag ttatgttcga tctggagagc ttaatttgga gttagttaac 1320acaacaggta ctggttatga aaatcatgct ttgttgaaga atgaggctaa agttccattg 1380atgtctttcg ttgcttctag tgatgaagct tcagccgaaa tcagtaactt gtcggtttct 1440gatttacaga ttcatgtagc aactccagag attgaagaag acacatacgg ccatatggga 1500gattggtctg aggctaaaat tcaagatgga actcttgtca ttaattggaa tcctactgga 1560tatcgattag atcctcaaaa agcaggggct ttagtattta atgcattatg ggaagaaggg 1620gctgtcttgt ctgctctgaa aaatgcacgc tttgctcata atctcactgc tcagcgtatg 1680gaattcgatt attctacaaa tgtgtgggga ttcgcctttg gtggtttccg aactctatct 1740gcagagaatc tggttgctat tgatggatac aaaggagctt atggtggtgc ttctgctgga 1800gtcgatattc aattgatgga agattttgtt ctaggagtta gtggagctgc tttcctaggt 1860aaaatggata gtcagaagtt tgatgcggag gtttctcgga agggagttgt tggttctgta 1920tatacaggat ttttagctgg atcctggttc ttcaaaggac aatatagcct tggagaaaca 1980cagaacgata tgaaaacgcg ttatggagta ctaggagagt cgagtgcttc ttggacatct 2040cgaggagtac tggcagatgc tttagttgaa taccgaagtt tagttggtcc tgtgagacct 2100actttttatg ctttgcattt caatccttat gtcgaagtat cttatgcttc tatgaaattc 2160cctggcttta cagaacaagg aagagaagcg cgttcttttg aagacgcttc ccttaccaat 2220atcaccattc ctttagggat gaagtttgaa ttggcgttca taaaaggaca gttttcagag 2280gtgaactctt tgggaataag ttatgcatgg gaagcttatc gaaaagtaga aggaggcgcg 2340gtgcagcttt tagaagctgg gtttgattgg gagggagctc caatggatct tcctagacag 2400gagctgcgtg tcgctctgga aaataatacg gaatggagtt cttacttcag cacagtctta 2460ggattaacag ctttttgtgg aggatttact tctacagata gtaaactagg atatgaggcg 2520aatactggat tgcgattgat cttttaa 2547

<210>185

<211>2337

<212>DNA

<213>衣原体属

<400>185atgcatcacc atcaccatca cgggttagct agttgcgtag atcttcatgc tggaggacag 60tctgtaaatg agctggtata tgtaggccct caagcggttt tattgttaga ccaaattcga 120gatctattcg ttgggtctaa agatagtcag gctgaaggac agtataggtt aattgtagga 180gatccaagtt ctttccaaga gaaagatgca gatactcttc ccgggaaggt agagcaaagt 240actttgttct cagtaaccaa tcccgtggtt ttccaaggtg tggaccaaca ggatcaagtc 300tcttcccaag ggttaatttg tagttttacg agcagcaacc ttgattctcc ccgtgacgga 360gaatcttttt taggtattgc ttttgttggg gatagtagta aggctggaat cacattaact 420gacgtgaaag cttctttgtc tggagcggct ttatattcta cagaagatct tatctttgaa 480aagattaagg gtggattgga atttgcatca tgttcttctc tagaacaggg gggagcttgt 540gcagctcaaa gtattttgat tcatgattgt caaggattgc aggttaaaca ctgtactaca 600gccgtgaatg ctgaggggtc tagtgcgaat gatcatcttg gatttggagg aggcgctttc 660tttgttacgg gttctctttc tggagagaaa agtctctata tgcctgcagg agatatggta 720gttgcgaatt gtgatggggc tatatctttt gaaggaaaca gcgcgaactt tgctaatgga 780ggagcgattg ctgcctctgg gaaagtgctt tttgtcgcta atgataaaaa gacttctttt 840atagagaacc gagctttgtc tggaggagcg attgcagcct cttctgatat tgcctttcaa 900aactgcgcag aactagtttt caaaggcaat tgtgcaattg gaacagagga taaaggttct 960ttaggtggag gggctatatc ttctctaggc accgttcttt tgcaagggaa tcacgggata 1020acttgtgata agaatgagtc tgcttcgcaa ggaggcgcca tttttggcaa aaattgtcag 1080atttctgaca acgaggggcc agtggttttc agagatagta cagcttgctt aggaggaggc 1140gctattgcag ctcaagaaat tgtttctatt cagaacaatc aggctgggat ttccttcgag 1200ggaggtaagg ctagtttcgg aggaggtatt gcgtgtggat ctttttcttc cgcaggcggt 1260gcttctgttt tagggactat tgatatttcg aagaatttag gcgcgatttc gttctctcgt 1320actttatgta cgacctcaga tttaggacaa atggagtacc agggaggagg agctctattt 1380ggtgaaaata tttctctttc tgagaatgct ggtgtgctca cctttaaaga caacattgtg 1440aagacttttg cttcgaatgg gaaaattctg ggaggaggag cgattttagc tactggtaag 1500gtggaaatta ccaataattc cggaggaatt tcttttacag gaaatgcgag agctccacaa 1560gctcttccaa ctcaagagga gtttccttta ttcagcaaaa aagaagggcg accactctct 1620tcaggatatt ctgggggagg agcgatttta ggaagagaag tagctattct ccacaacgct 1680gcagtagtat ttgagcaaaa tcgtttgcag tgcagcgaag aagaagcgac attattaggt 1740tgttgtggag gaggcgctgt tcatgggatg gatagcactt cgattgttgg caactcttca 1800gtaagatttg gtaataatta cgcaatggga caaggagtct caggaggagc tcttttatct 1860aaaacagtgc agttagctgg aaatggaagc gtcgattttt ctcgaaatat tgctagtttg 1920ggaggaggag ctcttcaagc ttctgaagga aattgtgagc tagttgataa cggctatgtg 1980ctattcagag ataatcgagg gagggtttat gggggtgcta tttcttgctt acgtggagat 2040gtagtcattt ctggaaacaa gggtagagtt gaatttaaag acaacatagc aacacgtctt 2100tatgtggaag aaactgtaga aaaggttgaa gaggtagagc cagctcctga gcaaaaagac 2160aataatgagc tttctttctt agggagtgta gaacagagtt ttattactgc agctaatcaa 2220gctcttttcg catctgaaga tggggattta tcacctgagt catccatttc ttctgaagaa 2280cttgcgaaaa gaagagagtg tgctggagga gctgactcga gcagatccgg ctgctaa 2337

<210>186

<211>2847

<212>DNA

<213>衣原体属

<400>186atggctagca tgcatcacca tcaccatcac gttaagattg agaacttctc tggccaagga 60atattttctg gaaacaaagc tatcgataac accacagaag gctcctcttc caaatctaac 120gtcctcggag gtgcggtcta tgctaaaaca ttgtttaatc tcgatagcgg gagctctaga 180cgaactgtca ccttctccgg gaatactgtc tcttctcaat ctacaacagg tcaggttgct 240ggaggagcta tctactctcc tactgtaacc attgctactc ctgtagtatt ttctaaaaac 300tctgcaacaa acaatgctaa taacgctaca gatactcaga gaaaagacac ctttggagga 360gctatcggag ctacttctgc tgtttctcta tcaggagggg ctcatttctt agaaaacgtt 420gctgacctcg gatctgctat tgggttggtg ccagacacac aaaatacaga aacagtgaaa 480ttagagtctg gctcctacta ctttgaaaaa aataaagctt taaaacgagc tactatttac 540gcacctgtcg tttccattaa agcctatact gcgacattta accaaaacag atctctagaa 600gaaggaagcg cgatttactt tacaaaagaa gcatctattg agtctttagg ctctgttctc 660ttcacaggaa acttagtaac cccaacgcta agcacaacta cagaaggcac accagccaca 720acctcaggag atgtaacaaa atatggtgct gctatctttg gacaaatagc aagctcaaac 780ggatctcaga cggataacct tcccctgaaa ctcattgctt caggaggaaa tatttgtttc 840cgaaacaatg aataccgtcc tacttcttct gataccggaa cctctacttt ctgtagtatt 900gcgggagatg ttaaattaac catgcaagct gcaaaaggga aaacgatcag tttctttgat 960gcaatccgga cctctactaa gaaaacaggt acacaggcaa ctgcctacga tactctcgat 1020attaataaat ctgaggattc agaaactgta aactctgcgt ttacaggaac gattctgttc 1080tcctctgaat tacatgaaaa taaatcctat attccacaaa acgtagttct acacagtgga 1140tctcttgtat tgaagccaaa taccgagctt catgtcattt cttttgagca gaaagaaggc 1200tcttctctcg ttatgacacc tggatctgtt ctttcgaacc agactgttgc tgatggagct 1260ttggtcataa ataacatgac cattgattta tccagcgtag agaaaaatgg tattgctgaa 1320ggaaatatct ttactcctcc agaattgaga atcatagaca ctactacaag tggaagcggt 1380ggaaccccat ctacagatag tgaaagtaac cagaatagtg atgataccaa ggagcaaaat 1440aataatgacg cctcgaatca aggagaaagc gcgaatggat cgtcttctcc tgcagtagct 1500gctgcacaca catctcgtac aagaaacttt gccgctgcag ctacagccac acctacgaca 1560acaccaacgg ctacaactac aacaagcaac caagtaatcc taggaggaga aatcaaactc 1620atcgatccta atgggacctt cttccagaac cctgcattaa gatccgacca acaaatctcc 1680ttgttagtgc tccctacaga ctcatcaaaa atgcaagctc agaaaatagt actgacgggt 1740gatattgctc ctcagaaagg atatacagga acactcactc tggatcctga tcaactacaa 1800aatggaacga tctcagcgct ctggaaattt gactcttata gacaatgggc ttatgtacct 1860agagacaatc atttctatgc gaactcgatt ctgggatctc aaatgtcaat ggtcacagtc 1920aaacaaggct tgctcaacga taaaatgaat ctagctcgct ttgatgaagt tagctataac 1980aacctgtgga tatcaggact aggaacgatg ctatcgcaag taggaacacc tacttctgaa 2040gaattcactt attacagcag aggagcttct gttgccttag atgctaaacc agcccatgat 2100gtgattgttg gagctgcatt tagtaagatg atcgggaaaa caaaatcctt gaaaagagag 2160aataactaca ctcacaaagg atccgaatat tcttaccaag catcggtata cggaggcaaa 2220ccattccact ttgtaatcaa taaaaaaacg gaaaaatcgc taccgctatt gttacaagga 2280gtcatctctt acggatatat caaacatgat acagtgactc actatccaac gatccgtgaa 2340cgaaaccaag gagaatggga agacttagga tggctgacag ctctccgtgt ctcctctgtc 2400ttaagaactc ctgcacaagg ggatactaaa cgtatcactg tttacggaga attggaatac 2460tccagtatcc gtcagaaaca attcacagaa acagaatacg atcctcgtta cttcgacaac 2520tgcacctata gaaacttagc aattcctatg gggttagcat tcgaaggaga gctctctggt 2580aacgatattt tgatgtacaa cagattctct gtagcataca tgccatcaat ctatcgaaat 2640tctccaacat gcaaatacca agtgctctct tcaggagaag gcggagaaat tatttgtgga 2700gtaccgacaa gaaactcagc tcgcggagaa tacagcacgc agctgtaccc gggacctttg 2760tggactctgt atggatccta cacgatagaa gcagacgcac atacactagc tcatatgatg 2820aactgcggtg ctcgtatgac attctaa 2847

<210>187

<211>2466

<212>DNA

<213>衣原体属

<400>187atgcatcacc atcaccatca cgaggcgagc tcgatccaag atcaaataaa gaataccgac 60tgcaatgtta gcaaagtagg atattcaact tctcaagcat ttactgatat gatgctagca 120gacaacacag agtatcgagc tgctgatagt gtttcattct atgacttttc gacatcttcc 180ggattaccta gaaaacatct tagtagtagt agtgaagctt ctccaacgac agaaggagtg 240tcttcatctt catctggaga aaatactgag aattcacaag attcagctcc ctcttctgga 300gaaactgata agaaaacaga agaagaacta gacaatggcg gaatcattta tgctagagag 360aaactaacta tctcagaatc tcaggactct ctctctaatc caagcataga actccatgac 420aatagttttt tcttcggaga aggtgaagtt atctttgatc acagagttgc cctcaaaaac 480ggaggagcta tttatggaga gaaagaggta gtctttgaaa acataaaatc tctactagta 540gaagtaaata tctcggtcga gaaagggggt agcgtctatg caaaagaacg agtatcttta 600gaaaatgtta ccgaagcaac cttctcctcc aatggtgggg aacaaggtgg tggtggaatc 660tattcagaac aagatatgtt aatcagtgat tgcaacaatg tacatttcca agggaatgct 720gcaggagcaa cagcagtaaa acaatgtctg gatgaagaaa tgatcgtatt gctcacagaa 780tgcgttgata gcttatccga agatacactg gatagcactc cagaaacgga acagactaag 840tcaaatggaa atcaagatgg ttcgtctgaa acaaaagata cacaagtatc agaatcacca 900gaatcaactc ctagccccga cgatgtttta ggtaaaggtg gtggtatcta tacagaaaaa 960tctttgacca tcactggaat tacagggact atagattttg tcagtaacat agctaccgat 1020tctggagcag gtgtattcac taaagaaaac ttgtcttgca ccaacacgaa tagcctacag 1080tttttgaaaa actcggcagg tcaacatgga ggaggagcct acgttactca aaccatgtct 1140gttactaata caactagtga aagtataact actccccctc tcgtaggaga agtgattttc 1200tctgaaaata cagctaaagg gcacggtggt ggtatctgca ctaacaaact ttctttatct 1260aatttaaaaa cggtgactct cactaaaaac tctgcaaagg agtctggagg agctattttt 1320acagatctag cgtctatacc aacaacagat accccagagt cttctacccc ctcttcctcc 1380tcgcctgcaa gcactcccga agtagttgct tctgctaaaa taaatcgatt ctttgcctct 1440acggcagaac cggcagcccc ttctctaaca gaggctgagt ctgatcaaac ggatcaaaca 1500gaaacttctg atactaatag cgatatagac gtgtcgattg agaacatttt gaatgtcgct 1560atcaatcaaa acacttctgc gaaaaaagga ggggctattt acgggaaaaa agctaaactt 1620tcccgtatta acaatcttga actttcaggg aattcatccc aggatgtagg aggaggtctc 1680tgtttaactg aaagcgtaga atttgatgca attggatcgc tcttatccca ctataactct 1740gctgctaaag aaggtggggt tattcattct aaaacggtta ctctatctaa cctcaagtct 1800accttcactt ttgcagataa cactgttaaa gcaatagtag aaagcactcc tgaagctcca 1860gaagagattc ctccagtaga aggagaagag tctacagcaa cagaaaatcc gaattctaat 1920acagaaggaa gttcggctaa cactaacctt gaaggatctc aaggggatac tgctgataca 1980gggactggtg ttgttaacaa tgagtctcaa gacacatcag atactggaaa cgctgaatct 2040ggagaacaac tacaagattc tacacaatct aatgaagaaa atacccttcc caatagtagt 2100attgatcaat ctaacgaaaa cacagacgaa tcatctgata gccacactga ggaaataact 2160gacgagagtg tctcatcgtc ctctaaaagt ggatcatcta ctcctcaaga tggaggagca 2220gcttcttcag gggctccctc aggagatcaa tctatctctg caaacgcttg tttagctaaa 2280agctatgctg cgagtactga tagctcccct gtatctaatt cttcaggttc agacgttact 2340gcatcttctg ataatccaga ctcttcctca tctggagata gcgctggaga ctctgaagga 2400ccgactgagc cagaagGtgg ttctacaaca gaaactccta ctttaatagg aggaggtgct 2460atctga 2466

<210>188

<211>1578

<212>DNA

<213>衣原体属

<400>188atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt cccgctagta 420cctagaggtt caccgctgcc tgtggggaat ccagctgaac caagtttatt aatcgatggc 480actatgtggg aaggtgcttc aggagatcct tgcgatcctt gcgctacttg gtgtgacgcc 540attagcatcc gcgcaggata ctacggagat tatgttttcg atcgtgtatt aaaagttgat 600gtgaataaaa cttttagcgg catggctgca actcctacgc aggctatagg taacgcaagt 660aatactaatc agccagaagc aaatggcaga ccgaacatcg cttacggaag gcatatgcaa 720gatgcagagt ggttttcaaa tgcagccttc ctagccttaa acatttggga tcgcttcgac 780attttctgca ccttaggggc atccaatgga tacttcaaag caagttcggc tgcattcaac 840ttggttgggt taatagggtt ttcagctgca agctcaatct ctaccgatct tccaatgcaa 900cttcctaacg taggcattac ccaaggtgtt gtggaatttt atacagacac atcattttct 960tggagcgtag gtgcacgtgg agctttatgg gaatgtggtt gtgcaacttt aggagctgag 1020ttccaatacg ctcaatctaa tcctaagatt gagatgctca acgtcacttc aagcccagca 1080caatttgtga ttcacaaacc aagaggctat aaaggagcta gctcgaattt tcctttacct 1140ataacggctg gaacaacaga agctacagac accaaatcag ctacaattaa ataccatgaa 1200tggcaagtag gcctcgccct gtcttacaga ttgaatatgc ttgttccata tattggcgta 1260aactggtcaa gagcaacttt tgatgctgat actatccgca ttgctcaacc taaattaaaa 1320tcggagattc ttaacattac tacatggaac ccaagcctta taggatcaac cactgctttg 1380cccaataata gtggtaagga tgttctatct gatgtcttgc aaattgcttc gattcagatc 1440aacaaaatga agtctagaaa agcttgtggt gtagctgttg gtgcaacgtt aatcgacgct 1500gacaaatggt caatcactgg tgaagcacgc ttaatcaatg aaagagctgc tcacatgaat 1560gcacaattcc gcttctaa 1578

<210>189

<211>866

<212>PRT

<213>衣原体属

<220>

<221>VARIANT

<222>220，242，425，448，453，455

<223>Xaa＝任何氨基酸

<400>189Met Ala Ser His His His His His His Leu Phe Gly Gln Asp Pro Leu1 5 10 15Gly Glu Thr Ala Leu Leu Thr Lys Asn Pro Asn His Val Val Cys Thr

20 25 30Phe Phe Glu Asp Cys Thr Met Glu Ser Leu Phe Pro Ala Leu Cys Ala

35 40 45His Ala Ser Gln Asp Asp Pro Leu Tyr Val Leu Gly Asn Ser Tyr Cys

50 55 60Trp Phe Val Ser Lys Leu His Ile Thr Asp Pro Lys Glu Ala Leu Phe65 70 75 80Lys Glu Lys Gly Asp Leu Ser Ile Gln Asn Phe Arg Phe Leu Ser Phe

85 90 95Thr Asp Cys Ser Ser Lys Glu Ser Ser Pro Ser Ile Ile His Gln Lys

100 105 110Asn Gly Gln Leu Ser Leu Arg Asn Asn Gly Ser Met Ser Phe Cys Arg

115 120 125Asn His Ala Glu Gly Ser Gly Gly Ala Ile Ser Ala Asp Ala Phe Ser

130 135 140Leu Gln His Asn Tyr Leu Phe Thr Ala Phe Glu Glu Asn Ser Ser Lys145 150 155 160Gly Asn Gly Gly Ala Ile Gln Ala Gln Thr Phe Ser Leu Ser Arg Asn

165 170 175Val Ser Pro Ile Ser Phe Ala Arg Asn Arg Ala Asp Leu Asn Gly Gly

180 185 190Ala Ile Cys Cys Ser Asn Leu Ile Cys Ser Gly Asn Val Asn Pro Leu

195 200 205Phe Phe Thr Gly Asn Ser Ala Thr Asn Gly Gly Xaa Ile Cys Cys Ile

210 215 220Ser Asp Leu Asn Thr Ser Glu Lys Gly Ser Leu Ser Leu Ala Cys Asn225 230 235 240Gln Xaa Thr Leu Phe Ala Ser Asn Ser Ala Lys Glu Lys Gly Gly Ala

245 250 255Ile Tyr Ala Lys His Met Val Leu Arg Tyr Asn Gly Pro Val Ser Phe

260 265 270Ile Asn Asn Ser Ala Lys Ile Gly Gly Ala Ile Ala Ile Gln Ser Gly

275 280 285Gly Ser Leu Ser Ile Leu Ala Gly Glu Gly Ser Val Leu Phe Gln Asn

290 295 300Asn Ser Gln Arg Thr Ser Asp Gln Gly Leu Val Arg Asn Ala Ile Tyr305 310 315 320Leu Glu Lys Asp Ala Ile Leu Ser Ser Leu Glu Ala Arg Asn Gly Asp

325 330 335Ile Leu Phe Phe Asp Pro Ile Val Gln Glu Ser Ser Ser Lys Glu Ser

340 345 350Pro Leu Pro Ser Ser Leu Gln Ala Ser Val Thr Ser Pro Thr Pro Ala

355 360 365Thr Ala Ser Pro Leu Val Ile Gln Thr Ser Ala Asn Arg Ser Val Ile

370 375 380Phe Ser Ser Glu Arg Leu Ser Glu Glu Glu Lys Thr Pro Asp Asn Leu385 390 395 400Thr Ser Gln Leu Gln Gln Pro Ile Glu Leu Lys Ser Gly Arg Leu Val

405 410 415Leu Lys Asp Arg Ala Val Leu Ser Xaa Pro Ser Leu Ser Gln Asp Pro

420 425 430Gln Ala Leu Leu Ile Met Glu Ala Gly Thr Ser Leu Lys Thr Ser Xaa

435 440 445Asp Leu Lys Leu Xaa Thr Xaa Ser Ile Pro Leu His Ser Leu Asp Thr

450 455 460Glu Lys Ser Val Thr Ile His Ala Pro Asn Leu Ser Ile Gln Lys Ile465 470 475 480Phe Leu Ser Asn Ser Gly Asp Glu Asn Phe Tyr Glu Asn Val Glu Leu

485 490 495Leu Ser Lys Glu Gln Asn Asn Ile Pro Leu Leu Thr Leu Pro Lys Glu

500 505 510Gln Ser His Leu His Leu Pro Asp Gly Asn Leu Ser Ser His Phe Gly

515 520 525Tyr Gln Gly Asp Trp Thr Phe Ser Trp Lys Asp Ser Asp Glu Gly His

530 535 540Ser Leu Ile Ala Asn Trp Thr Pro Lys Asn Tyr Val Pro His Pro Glu545 550 555 560Arg Gln Ser Thr Leu Val Ala Asn Thr Leu Trp Asn Thr Tyr Ser Asp

565 570 575Met Gln Ala Val Gln Ser Met Ile Asn Thr Thr Ala His Gly Gly Ala

580 585 590Tyr Leu Phe Gly Thr Trp Gly Ser Ala Val Ser Asn Leu Phe Tyr Val

595 600 605His Asp Ser Ser Gly Lys Pro Ile Asp Asn Trp His His Arg Ser Leu

610 615 620Gly Tyr Leu Phe Gly Ile Ser Thr His Ser Leu Asp Asp His Ser Phe625 630 635 640Cys Leu Ala Ala Gly Gln Leu Leu Gly Lys Ser Ser Asp Ser Phe Ile

645 650 655Thr Ser Thr Glu Thr Thr Ser Tyr Ile Ala Thr Val Gln Ala Gln Leu

660 665 670Ala Thr Ser Leu Met Lys Ile Ser Ala Gln Ala Cys Tyr Asn Glu Ser

675 680 685Ile His Glu Leu Lys Thr Lys Tyr Arg Ser Phe Ser Lys Glu Gly Phe

690 695 700Gly Ser Trp His Ser Val Ala Val Ser Gly Glu Val Cys Ala Ser Ile705 710 715 720Pro Ile Val Ser Asn Gly Ser Gly Leu Phe Ser Ser Phe Ser Ile Phe

725 730 735Ser Lys Leu Gln Gly Phe Ser Gly Thr Gln Asp Gly Phe Glu Glu Ser

740 745 750Ser Gly Glu Ile Arg Ser Phe Ser Ala Ser Ser Phe Arg Asn Ile Ser

755 760 765Leu Pro Ile Gly Ile Thr Phe Glu Lys Lys Ser Gln Lys Thr Arg Thr

770 775 780Tyr Tyr Tyr Phe Leu Gly Ala Tyr Ile Gln Asp Leu Lys Arg Asp Val785 790 795 800Glu Ser Gly Pro Val Val Leu Leu Lys Asn Ala Val Ser Trp Asp Ala

805 810 815Pro Met Ala Asn Leu Asp Ser Arg Ala Tyr Met Phe Arg Leu Thr Asn

820 825 830Gln Arg Ala Leu His Arg Leu Gln Thr Leu Leu Asn Val Ser Cys Val

835 840 845Leu Arg Gly Gln Ser His Ser Tyr Ser Leu Asp Leu Gly Thr Thr Tyr

850 855 860Arg Phe865

<210>190

<211>1006

<212>PRT

<213>衣原体属

<400>190Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Asp Ser Ser Leu1 5 10 15Val Pro His His His His His His Met Ile Pro Gln Gly Ile Tyr Asp

20 25 30Gly Glu Thr Leu Thr Val Ser Phe Pro Tyr Thr Val Ile Gly Asp Pro

35 40 45Ser Gly Thr Thr Val Phe Ser Ala Gly Glu Leu Thr Leu Lys Asn Leu

50 55 60Asp Asn Ser Ile Ala Ala Leu Pro Leu Ser Cys Phe Gly Asn Leu Leu65 70 75 80Gly Ser Phe Thr Val Leu Gly Arg Gly His Ser Leu Thr Phe Glu Asn

85 90 95Ile Arg Thr Ser Thr Asn Gly Ala Ala Leu Ser Asn Ser Ala Ala Asp

100 105 110Gly Leu Phe Thr Ile Glu Gly Phe Lys Glu Leu Ser Phe Ser Asn Cys

115 120 125Asn Ser Leu Leu Ala Val Leu Pro Ala Ala Thr Thr Asn Lys Gly Ser

130 135 140Gln Thr Pro Thr Thr Thr Ser Thr Pro Ser Asn Gly Thr Ile Tyr Ser145 150 155 160Lys Thr Asp Leu Leu Leu Leu Asn Asn Glu Lys Phe Ser Phe Tyr Ser

165 170 175Asn Leu Val Ser Gly Asp Gly Gly Ala Ile Asp Ala Lys Ser Leu Thr

180 185 190Val Gln Gly Ile Ser Lys Leu Cys Val Phe Gln Glu Asn Thr Ala Gln

195 200 205Ala Asp Gly Gly Ala Cys Gln Val Val Thr Ser Phe Ser Ala Met Ala

210 215 220Asn Glu Ala Pro Ile Ala Phe Val Ala Asn Val Ala Gly Val Arg Gly225 230 235 240Gly Gly Ile Ala Ala Val Gln Asp Gly Gln Gln Gly Val Ser Ser Ser

245 250 255Thr Ser Thr Glu Asp Pro Val Val Ser Phe Ser Arg Asn Thr Ala Val

260 265 270Glu Phe Asp Gly Asn Val Ala Arg Val Gly Gly Gly Ile Tyr Ser Tyr

275 280 285Gly Asn Val Ala Phe Leu Asn Asn Gly Lys Thr Leu Phe Leu Asn Asn

290 295 300Val Ala Ser Pro Val Tyr Ile Ala Ala Lys Gln Pro Thr Ser Gly Gln305 310 315 320Ala Ser Asn Thr Ser Asn Asn Tyr Gly Asp Gly Gly Ala Ile Phe Cys

325 330 335Lys Asn Gly Ala Gln Ala Gly Ser Asn Asn Ser Gly Ser Val Ser Phe

340 345 350Asp Gly Glu Gly Val Val Phe Phe Ser Ser Asn Val Ala Ala Gly Lys

355 360 365Gly Gly Ala Ile Tyr Ala Lys Lys Leu Ser Val Ala Asn Cys Gly Pro

370 375 380Val Gln Phe Leu Arg Asn Ile Ala Asn Asp Gly Gly Ala Ile Tyr Leu385 390 395 400Gly Glu Ser Gly Glu Leu Ser Leu Ser Ala Asp Tyr Gly Asp Ile Ile

405 410 415Phe Asp Gly Asn Leu Lys Arg Thr Ala Lys Glu Asn Ala Ala Asp Val

420 425 430Asn Gly Val Thr Val Ser Ser Gln Ala Ile Ser Met Gly Ser Gly Gly

435 440 445Lys Ile Thr Thr Leu Arg Ala Lys Ala Gly His Gln Ile Leu Phe Asn

450 455 460Asp Pro Ile Glu Met Ala Asn Gly Asn Asn Gln Pro Ala Gln Ser Ser465 470 475 480Lys Leu Leu Lys Ile Asn Asp Gly Glu Gly Tyr Thr Gly Asp Ile Val

485 490 495Phe Ala Asn Gly Ser Ser Thr Leu Tyr Gln Asn Val Thr Ile Glu Gln

500 505 510Gly Arg Ile Val Leu Arg Glu Lys Ala Lys Leu Ser Val Asn Ser Leu

515 520 525Ser Gln Thr Gly Gly Ser Leu Tyr Met Glu Ala Gly Ser Thr Leu Asp

530 535 540Phe Val Thr Pro Gln Pro Pro Gln Gln Pro Pro Ala Ala Asn Gln Leu545 550 555 560Ile Thr Leu Ser Asn Leu His Leu Ser Leu Ser Ser Leu Leu Ala Asn

565 570 575Asn Ala Val Thr Asn Pro Pro Thr Asn Pro Pro Ala Gln Asp Ser His

580 585 590Pro Ala Val Ile Gly Ser Thr Thr Ala Gly Ser Val Thr Ile Ser Gly

595 600 605Pro Ile Phe Phe Glu Asp Leu Asp Asp Thr Ala Tyr Asp Arg Tyr Asp

610 615 620Trp Leu Gly Ser Asn Gln Lys Ile Asn Val Leu Lys Leu Gln Leu Gly625 630 635 640Thr Lys Pro Pro Ala Asn Ala Pro Ser Asp Leu Thr Leu Gly Asn Glu

645 650 655Met Pro Lys Tyr Gly Tyr Gln Gly Ser Trp Lys Leu Ala Trp Asp Pro

660 665 670Asn Thr Ala Asn Asn Gly Pro Tyr Thr Leu Lys Ala Thr Trp Thr Lys

675 680 685Thr Gly Tyr Asn Pro Gly Pro Glu Arg Val Ala Ser Leu Val Pro Asn

690 695 700Ser Leu Trp Gly Ser Ile Leu AspIle Arg Ser Ala His Ser Ala Ile705 710 715 720Gln Ala Ser Val Asp Gly Arg Ser Tyr Cys Arg Gly Leu Trp Val Ser

725 730 735Gly Val Ser Asn Phe Phe Tyr His Asp Arg Asp Ala Leu Gly Gln Gly

740 745 750Tyr Arg Tyr Ile Ser Gly Gly Tyr Ser Leu Gly Ala Asn Ser Tyr Phe

755 760 765Gly Ser Ser Met Phe Gly Leu Ala Phe Thr Glu Val Phe Gly Arg Ser

770 775 780Lys Asp Tyr Val Val Cys Arg Ser Asn His His Ala Cys Ile Gly Ser785 790 795 800Val Tyr Leu Ser Thr Gln Gln Ala Leu Cys Gly Ser Tyr Leu Phe Gly

805 810 815Asp Ala Phe Ile Arg Ala Ser Tyr Gly Phe Gly Asn Gln His Met Lys

820 825 830Thr Ser Tyr Thr Phe Ala Glu Glu Ser Asp Val Arg Trp Asp Asn Asn

835 840 845Cys Leu Ala Gly Glu Ile Gly Ala Gly Leu Pro Ile Val Ile Thr Pro

850 855 860Ser Lys Leu Tyr Leu Asn Glu Leu Arg Pro Phe Val Gln Ala Glu Phe865 870 875 880Ser Tyr Ala Asp His Glu Ser Phe Thr Glu Glu Gly Asp Gln Ala Arg

885 890 895Ala Phe Lys Ser Gly His Leu Leu Asn Leu Ser Val Pro Val Gly Val

900 905 910Lys Phe Asp Arg Cys Ser Ser Thr His Pro Asn Lys Tyr Ser Phe Met

915 920 925Ala Ala Tyr Ile Cys Asp Ala Tyr Arg Thr Ile Ser Gly Thr Glu Thr

930 935 940Thr Leu Leu Ser His Gln Glu Thr Trp Thr Thr Asp Ala Phe His Leu945 950 955 960Ala Arg His Gly Val Val Val Arg Gly Ser Met Tyr Ala Ser Leu Thr

965 970 975Ser Asn Ile Glu Val Tyr Gly His Gly Arg Tyr Glu Tyr Arg Asp Ala

980 985 990Ser Arg Gly Tyr Gly Leu Ser Ala Gly Ser Lys Val Arg Phe

995 1000 1005

<210>191

<211>977

<212>PRT

<213>衣原体属

<400>191Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Asp Ser Ser Leu1 5 10 15Val Pro Ser Ser Asp Pro His His His His His His Gly Leu Ala Arg

20 25 30Glu Val Pro Ser Arg Ile Phe Leu Met Pro Asn Ser Val Pro Asp Pro

35 40 45Thr Lys Glu Ser Leu Ser Asn Lys Ile Ser Leu Thr Gly Asp Thr His

50 55 60Asn Leu Thr Asn Cys Tyr Leu Asp Asn Leu Arg Tyr Ile Leu Ala Ile65 70 75 80Leu Gln Lys Thr Pro Asn Glu Gly Ala Ala Val Thr Ile Thr Asp Tyr

85 90 95Leu Ser Phe Phe Asp Thr Gln Lys Glu Gly Ile Tyr Phe Ala Lys Asn

100 105 110Leu Thr Pro Glu Ser Gly Gly Ala Ile Gly Tyr Ala Ser Pro Asn Ser

115 120 125Pro Thr Val Glu Ile Arg Asp Thr Ile Gly Pro Val Ile Phe Glu Asn

130 135 140Asn Thr Cys Cys Arg Leu Phe Thr Trp Arg Asn Pro Tyr Ala Ala Asp145 150 155 160Lys Ile Arg Glu Gly Gly Ala Ile His Ala Gln Asn Leu Tyr Ile Asn

165 170 175His Asn His Asp Val Val Gly Phe Met Lys Asn Phe Ser Tyr Val Gln

180 185 190Gly Gly Ala Ile Ser Thr Ala Asn Thr Phe Val Val Ser Glu Asn Gln

195 200 205Ser Cys Phe Leu Phe Met Asp Asn Ile Cys Ile Gln Thr Asn Thr Ala

210 215 220Gly Lys Gly Gly Ala Ile Tyr Ala Gly Thr Ser Asn Ser Phe Glu Ser225 230 235 240Asn Asn Cys Asp Leu Phe Phe Ile Asn Asn Ala Cys Cys Ala Gly Gly

245 250 255Ala Ile Phe Ser Pro Ile Cys Ser Leu Thr Gly Asn Arg Gly Asn Ile

260 265 270Val Phe Tyr Asn Asn Arg Cys Phe Lys Asn Val Glu Thr Ala Ser Ser

275 280 285Glu Ala Ser Asp Gly Gly Ala Ile Lys Val Thr Thr Arg Leu Asp Val

290 295 300Thr Gly Asn Arg Gly Arg Ile Phe Phe Ser Asp Asn Ile Thr Lys Asn305 310 315 320Tyr Gly Gly Ala Ile Tyr Ala Pro Val Val Thr Leu Val Asp Asn Gly

325 330 335Pro Thr Tyr Phe Ile Asn Asn Ile Ala Asn Asn Lys Gly Gly Ala Ile

340 345 350Tyr Ile Asp Gly Thr Ser Asn Ser Lys Ile Ser Ala Asp Arg His Ala

355 360 365Ile Ile Phe Asn Glu Asn Ile Val Thr Asn Val Thr Asn Ala Asn Gly

370 375 380Thr Ser Thr Ser Ala Asn Pro Pro Arg Arg Asn Ala Ile Thr Val Ala385 390 395 400Ser Ser Ser Gly Glu Ile Leu Leu Gly Ala Gly Ser Ser Gln Asn Leu

405 410 415Ile Phe Tyr Asp Pro Ile Glu Val Ser Asn Ala Gly Val Ser Val Ser

420 425 430Phe Asn Lys Glu Ala Asp Gln Thr Gly Ser Val Val Phe Ser Gly Ala

435 440 445Thr Val Asn Ser Ala Asp Phe His Gln Arg Asn Leu Gln Thr Lys Thr

450 455 460Pro Ala Pro Leu Thr Leu Ser Asn Gly Phe Leu Cys Ile Glu Asp His465 470 475 480Ala Gln Leu Thr Val Asn Arg Phe Thr Gln ThrGly Gly Val Val Ser

485 490 495Leu Gly Asn Gly Ala Val Leu Ser Cys Tyr Lys Asn Gly Thr Gly Asp

500 505 510Ser Ala Ser Asn Ala Ser Ile Thr Leu Lys His Ile Gly Leu Asn Leu

515 520 525Ser Ser Ile Leu Lys Ser Gly Ala Glu Ile Pro Leu Leu Trp Val Glu

530 535 540Pro Thr Asn Asn Ser Asn Asn Tyr Thr Ala Asp Thr Ala Ala Thr Phe545 550 555 560Ser Leu Ser Asp Val Lys Leu Ser Leu Ile Asp Asp Tyr Gly Asn Ser

565 570 575Pro Tyr Glu Ser Thr Asp Leu Thr His Ala Leu Ser Ser Gln Pro Met

580 585 590Leu Ser Ile Ser Glu Ala Ser Asp Asn Gln Leu Gln Ser Glu Asn Ile

595 600 605Asp Phe Ser Gly Leu Asn Val Pro His Tyr Gly Trp Gln Gly Leu Trp

610 615 620Thr Trp Gly Trp Ala Lys Thr Gln Asp Pro Glu Pro Ala Ser Ser Ala625 630 635 640Thr Ile Thr Asp Pro Gln Lys Ala Asn Arg Phe His Arg Thr Leu Leu

645 650 655Leu Thr Trp Leu Pro Ala Gly Tyr Val Pro Ser Pro Lys His Arg Ser

660 665 670Pro Leu Ile Ala Asn Thr Leu Trp Gly Asn Met Leu Leu Ala Thr Glu

675 680 685ser Leu Lys Asn Ser Ala Glu Leu Thr Pro Ser Gly His Pro Phe Trp

690 695 700Gly Ile Thr Gly Gly Gly Leu Gly Met Met Val Tyr Gln Asp Pro Arg705 710 715 720Glu Asn His Pro Gly Phe His Met Arg Ser Ser Gly Tyr Ser Ala Gly

725 730 735Met Ile Ala Gly Gln Thr His Thr Phe Ser Leu Lys Phe Ser Gln Thr

740 745 750Tyr Thr Lys Leu Asn Glu Arg Tyr Ala Lys Asn Asn Val Ser Ser Lys

755 760 765Asn Tyr Ser Cys Gln Gly Glu Met Leu Phe Ser Leu Gln Glu Gly Phe

770 775 780Leu Leu Thr Lys Leu Val Gly Leu Tyr Ser Tyr Gly Asp His Asn Cys785 790 795 800His His Phe Tyr Thr Gln Gly Glu Asn Leu Thr Ser Gln Gly Thr Phe

805 810 815Arg Ser Gln Thr Met Gly Gly Ala Val Phe Phe Asp Leu Pro Met Lys

820 825 830Pro Phe Gly Ser Thr His Ile Leu Thr Ala Pro Phe Leu Gly Ala Leu

835 840 845Gly Ile Tyr Ser Ser Leu Ser His Phe Thr Glu Val Gly Ala Tyr Pro

850 855 860Arg Ser Phe Ser Thr Lys Thr Pro Leu Ile Asn Val Leu Val Pro Ile865 870 875 880Gly Val Lys Gly Ser Phe Met Asn Ala Thr His Arg Pro Gln Ala Trp

885 890 895Thr Val Glu Leu Ala Tyr Gln Pro Val Leu Tyr Arg Gln Glu Pro Gly

900 905 910Ile Ala Thr Gln Leu Leu Ala Ser Lys Gly Ile Trp Phe Gly Ser Gly

915 920 925Ser Pro Ser Ser Arg His Ala Met Ser Tyr Lys Ile Ser Gln Gln Thr

930 935 940Gln Pro Leu Ser Trp Leu Thr Leu His Phe Gln Tyr His Gly Phe Tyr945 950 955 960Ser Ser Ser Thr Phe Cys Asn Tyr Leu Asn GLy Glu Ile Ala Leu Arg

965 970 975Phe<210>192<211>848<212>PRT<213>衣原体属<400>192Met Ala Ser His His His His His His Gly Ala Ile Ser Cys Leu Arg1 5 l0 15Gly Asp Val Val Ile Ser Gly Asn Lys Gly Arg Val Glu Phe Lys Asp

20 25 30Asn Ile Ala Thr Arg Leu Tyr Val Glu Glu Thr Val Glu Lys Val Glu

35 40 45Glu Val Glu Pro Ala Pro Glu Gln Lys Asp Asn Asn Glu Leu Ser Phe

50 55 60Leu Gly Ser Val Glu Gln Ser Phe Ile Thr Ala Ala Asn Gln Ala Leu65 70 75 80Phe Ala Ser Glu Asp Gly Asp Leu Ser Pro Glu Ser Ser Ile Ser Ser

85 90 95Glu Glu Leu Ala Lys Arg Arg Glu Cys Ala Gly Gly Ala Ile Phe Ala

100 105 110Lys Arg Val Arg Ile Val Asp Asn Gln Glu Ala Val Val Phe Ser Asn

115 120 125Asn Phe Ser Asp Ile Tyr Gly Gly Ala Ile Phe Thr Gly Ser Leu Arg

130 135 l40Glu Glu Asp Lys Leu Asp Gly Gln Ile Pro Glu Val Leu Ile Ser Gly145 150 155 160Asn Ala Gly Asp Val Val Phe Ser Gly Asn Ser Ser Lys Arg Asp Glu

165 170 175His Leu Pro His Thr Gly Gly Gly Ala Ile Cys Thr Gln Asn Leu Thr

180 185 190Ile Ser Gln Asn Thr Gly Asn Val Leu Phe Tyr Asn Asn Val Ala Cys

195 200 205Ser Gly Gly Ala Val Arg Ile Glu Asp His Gly Asn Val Leu Leu Glu

210 215 220Ala Phe Gly Gly Asp Ile Val Phe Lys Gly Asn Ser Ser Phe Arg Ala225 230 235 240Gln Gly Ser Asp Ala Ile Tyr Phe Ala Gly Lys Glu Ser His Ile Thr

245 250 255Ala Leu Asn Ala Thr Glu Gly His Ala Ile Val Phe His Asp Ala Leu

260 265 270Val Phe Glu Asn Leu Lys Glu Arg Lys Ser Ala Glu Val Leu Leu Ile

275 280 285Asn Ser Arg Glu Asn Pro Gly Tyr Thr Gly Ser Ile Arg Phe Leu Glu

290 295 300Ala Glu Ser Lys Val Pro Gln Cys Ile His Val Gln Gln Gly Ser Leu305 310 315 320Glu Leu Leu Asn Gly Ala Thr Leu Cys Ser Tyr Gly Phe Lys Gln Asp

325 330 335Ala Gly Ala Lys Leu Val Leu Ala Ala Gly Ser Lys Leu Lys Ile Leu

340 345 350Asp Ser Gly Thr Pro Val Gln Gly His Ala Ile Ser Lys Pro Glu Ala

355 360 365Glu Ile Glu Ser Ser Ser Glu Pro Glu Gly Ala His Ssr Leu Trp Ile

370 375 380Ala Lys Asn Ala Gln Thr Thr Val Pro Met Val Asp Ile His Thr Ile385 390 395 400Ser Val Asp Leu Ala Ser Phe Ser Ser Ser Gln Gln Glu Gly Thr Val

405 410 415Glu Ala Pro Gln Val Ile Val Pro Gly Gly Ser Tyr Val Arg Ser Gly

420 425 430Glu Leu Asn Leu Glu Leu Val Asn Thr Thr Gly Thr Gly Tyr Glu Asn

435 440 445His Ala Leu Leu Lys Asn Glu Ala Lys Val Pro Leu Met Ser Phe Val

450 455 460Ala Ser Ser Asp Glu Ala Ser Ala Glu Ile Ser Asn Leu Ser Val Ser465 470 475 480Asp Leu Gln Ile His Val Ala Thr Pro Glu Ile Glu Glu Asp Thr Tyr

485 490 495Gly His Met Gly Asp Trp Ser Glu Ala Lys Ile Gln Asp Gly Thr Leu

500 505 510Val Ile Asn Trp Asn Pro Thr Gly Tyr Arg Leu Asp Pro Gln Lys Ala

515 520 525Gly Ala Leu Val Phe Asn Ala Leu Trp Glu Glu Gly Ala Val Leu Ser

530 535 540Ala Leu Lys Asn Ala Arg Phe Ala His Asn Leu Thr Ala Gln Arg Met545 550 555 560Glu Phe Asp Tyr Ser Thr Asn Val Trp Gly Phe Ala Phe Gly Gly Phe

565 570 575Arg Thr Leu Ser Ala Glu Asn Leu Val Ala Ile Asp Gly Tyr Lys Gly

580 585 590Ala Tyr Gly Gly Ala Ser Ala Gly Val Asp Ile Gln Leu Met Glu Asp

595 600 605Phe Val Leu Gly Val Ser Gly Ala Ala Phe Leu Gly Lys Met Asp Ser

610 615 620Gln Lys Phe Asp Ala Glu Val Ser Arg Lys Gly Val Val Gly Ser Val625 630 635 640Tyr Thr Gly Phe Leu Ala Gly Ser Trp Phe Phe Lys Gly Gln Tyr Ser

645 650 655Leu Gly Glu Thr Gln Asn Asp Met Lys Thr Arg Tyr Gly Val Leu Gly

660 665 670Glu Ser Ser Ala Ser Trp Thr Ser Arg Gly Val Leu Ala Asp Ala Leu

675 680 685Val Glu Tyr Arg Ser Leu Val Gly Pro Val Arg Pro Thr Phe Tyr Ala

690 695 700Leu His Phe Asn Pro Tyr Val Glu Val Ser Tyr Ala Ser Met Lys Phe705 710 715 720Pro Gly Phe Thr Glu Gln Gly Arg Glu Ala Arg Ser Phe Glu Asp Ala

725 730 735Ser Leu Thr Asn Ile Thr Ile Pro Leu Gly Met Lys Phe Glu Leu Ala

740 745 750Phe Ile Lys Gly Gln Phe Ser Glu Val Asn Ser Leu Gly Ile Ser Tyr

755 760 765Ala Trp Glu Ala Tyr Arg Lys Val Glu Gly Gly Ala Val Gln Leu Leu

770 775 780Glu Ala Gly Phe Asp Trp Glu Gly Ala Pro Met Asp Leu Pro Arg Gln785 790 795 800Glu Leu Arg Val Ala Leu Glu Asn Asn Thr Glu Trp Ser Ser Tyr Phe

805 810 815Ser Thr Val Leu Gly Leu Thr Ala Phe Cys Gly Gly Phe Thr Ser Thr

820 825 830Asp Ser Lys Leu Gly Tyr Glu Ala Asn Thr Gly Leu Arg Leu Ile Phe

835 840 845

<210>193

<211>778

<212>PRT

<213>衣原体属

<400>193Met His His His His His His Gly Leu Ala Ser Cys Val Asp Leu His1 5 10 15Ala Gly Gly Gln Ser Val Asn Glu Leu Val Tyr Val Gly Pro Gln Ala

20 25 30Val Leu Leu Leu Asp Gln Ile Arg Asp Leu Phe Val Gly Ser Lys Asp

35 40 45Ser Gln Ala Glu Gly Gln Tyr Arg Leu Ile Val Gly Asp Pro Ser Ser

50 55 60Phe Gln Glu Lys Asp Ala Asp Thr Leu Pro Gly Lys Val Glu Gln Ser65 70 75 80Thr Leu Phe Ser Val Thr Asn Pro Val Val Phe Gln Gly Val Asp Gln

85 90 95Gln Asp Gln Val Ser Ser Gln Gly Leu Ile Cys Ser Phe Thr Ser Ser

100 105 110Asn Leu Asp Ser Pro Arg Asp Gly Glu Ser Phe Leu Gly Ile Ala Phe

115 120 125Val Gly Asp Ser Ser Lys Ala Gly Ile Thr Leu Thr Asp Val Lys Ala

130 135 140Ser Leu Ser Gly Ala Ala Leu Tyr Ser Thr Glu Asp Leu Ile Phe Glu145 150 155 160Lys Ile Lys Gly Gly Leu Glu Phe Ala Ser Cys Ser Ser Leu Glu Gln

165 170 175Gly Gly Ala Cys Ala Ala Gln Ser Ile Leu Ile His Asp Cys Gln Gly

180 185 190Leu Gln Val Lys His Cys Thr Thr Ala Val Asn Ala Glu Gly Ser Ser

195 200 205Ala Asn Asp His Leu Gly Phe Gly Gly Gly Ala Phe Phe Val Thr Gly

210 215 220Ser Leu Ser Gly Glu Lys Ser Leu Tyr Met Pro Ala Gly Asp Met Val225 230 235 240Val Ala Asn Cys Asp Gly Ala Ile Ser Phe Glu Gly Asn Ser Ala Asn

245 250 255Phe Ala Asn Gly Gly Ala Ile Ala Ala Ser Gly Lys Val Leu Phe Val

260 265 270Ala Asn Asp Lys Lys Thr Ser Phe Ile Glu Asn Arg Ala Leu Ser Gly

275 280 285Gly Ala Ile Ala Ala Ser Ser Asp Ile Ala Phe Gln Asn Cys Ala Glu

290 295 300Leu Val Phe Lys Gly Asn Cys Ala Ile Gly Thr Glu Asp Lys Gly Ser305 310 315 320Leu Gly Gly Gly Ala Ile Seu Ser Leu Gly Thr Val Leu Leu Gln Gly

325 330 335Asn His Gly Ile Thr Cys Asp Lys Asn Glu Ser Ala Ser Gln Gly Gly

340 345 350Ala Ile Phe Gly Lys Asn Cys Gln Ile Ser Asp Asn Glu Gly Pro Val

355 360 365Val Phe Arg Asp Ser Thr Ala Cys Leu Gly Gly Gly Ala Ile Ala Ala

370 375 380Gln Glu Ile Val Ser Ile Gln Asn Asn Gln Ala Gly Ile Ser Phe Glu385 390 395 400Gly Gly Lys Ala Ser Phe Gly Gly Gly Ile Ala Cys Gly Ser Phe Ser

405 410 415Ser Ala Gly Gly Ala Ser Val Leu Gly Thr Ile Asp Ile Ser Lys Asn

420 425 430Leu Gly Ala Ile Ser Phe Ser Arg Thr Leu Cys Thr Thr Ser Asp Leu

435 440 445Gly Gln Met Glu Tyr Gln Gly Gly Gly Ala Leu Phe Gly Glu Asn Ile

450 455 460Ser Leu Ser Glu Asn Ala Gly Val Leu Thr Phe Lys Asp Asn Ile Val465 470 475 480Lys Thr Phe Ala Ser Asn Gly Lys Ile Leu Gly Gly Gly Ala Ile Leu

485 490 495Ala Thr Gly Lys Val Glu Ile Thr Asn Asn Ser Gly Gly Ile Ser Phe

500 505 510Thr Gly Asn Ala Arg Ala Pro Gln Ala Leu Pro Thr Gln Glu Glu Phe

515 520 525Pro Leu Phe Ser Lys Lys Glu Gly Arg Pro Leu Ser Ser Gly Tyr Ser

530 535 540Gly Gly Gly Ala Ile Leu Gly Arg Glu Val Ala Ile Leu His Asn Ala545 550 555 560Ala Val Val Phe Glu Gln Asn Arg Leu Gln Cys Ser Glu Glu Glu Ala

565 570 575Thr Leu Leu Gly Cys Cys Gly Gly Gly Ala Val His Gly Met Asp Ser

580 585 590Thr Ser Ile Val Gly Asn Ser Ser Val Arg Phe Gly Asn Asn Tyr Ala

595 600 605Met Gly Gln Gly Val Ser Gly Gly Ala Leu Leu Ser Lys Thr Val Gln

610 615 620Leu Ala Gly Asn Gly Ser Val Asp Phe Ser Arg Asn Ile Ala Ser Leu625 630 635 640Gly Gly Gly Ala Leu Gln Ala Ser Glu Gly Asn Cys Glu Leu Val Asp

645 650 655Asn Gly Tyr Val Leu Phe Arg Asp Asn Arg Gly Arg Val Tyr Gly Gly

660 665 670Ala Ile Ser Cys Leu Arg Gly Asp Val Val Ile Ser Gly Asn Lys Gly

675 680 685Arg Val Glu Phe Lys Asp Asn Ile Ala Thr Arg Leu Tyr Val Glu Glu

690 695 700Thr Val Glu Lys Val Glu Glu Val Glu Pro Ala Pro Glu Gln Lys Asp705 710 715 720Asn Asn Glu Leu Ser Phe Leu Gly Ser Val Glu Gln Ser Phe Ile Thr

725 730 735Ala Ala Asn Gln Ala Leu Phe Ala Ser Glu Asp Gly Asp Leu Ser Pro

740 745 750Glu Ser Ser Ile Ser Ser Glu Glu Leu Ala Lys Arg Arg Glu Cys Ala

755 760 765Gly Gly Ala Asp Ser Ser Arg Ser Gly Cys

770 775

<210>194

<211>948

<212>PRT

<213>衣原体属

<400>194Met Ala Ser Met His His His His His His Val Lys Ile Glu Asn Phe1 5 10 15Ser Gly Gln Gly Ile Phe Ser Gly Asn Lys Ala Ile Asp Asn Thr Thr

20 25 30Glu Gly Ser Ser Ser Lys Ser Asn Val Leu Gly Gly Ala Val Tyr Ala

35 40 45Lys Thr Leu Phe Asn Leu Asp Ser Gly Ser Ser Arg Arg Thr Val Thr

50 55 60Phe Ser Gly Asn Thr Val Ser Ser Gln Ser Thr Thr Gly Gln Val Ala65 70 75 80Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr Ile Ala Thr Pro Val Val

85 90 95Phe Ser Lys Asn Ser Ala Thr Asn Asn Ala Asn Asn Ala Thr Asp Thr

100 105 110Gln Arg Lys Asp Thr Phe Gly Gly Ala Ile Gly Ala Thr Ser Ala Val

115 120 125Ser Leu Ser Gly Gly Ala His Phe Leu Glu Asn Val Ala Asp Leu Gly

130 135 140Ser Ala Ile Gly Leu Val Pro Asp Thr Gln Asn Thr Glu Thr Val Lys145 150 155 160Leu Glu Ser Gly Ser Tyr Tyr Phe Glu Lys Asn Lys Ala Leu Lys Arg

165 170 175Ala Thr Ile Tyr Ala Pro Val Val Ser Ile Lys Ala Tyr Thr Ala Thr

180 185 190Phe Asn Gln Asn Arg Ser Leu Glu Glu Gly Ser Ala Ile Tyr Phe Thr

195 200 205Lys Glu Ala Ser Ile Glu Ser Leu Gly Ser Val Leu Phe Thr Gly Asn

210 215 220Leu Val Thr Pro Thr Leu Ser Thr Thr Thr Glu Gly Thr Pro Ala Thr225 230 235 240Thr Ser Gly Asp Val Thr Lys Tyr Gly Ala Ala Ile Phe Gly Gln Ile

245 250 255Ala Ser Ser Asn Gly Ser Gln Thr Asp Asn Leu Pro Leu Lys Leu Ile

260 265 270Ala Ser Gly Gly Asn Ile Cys Phe Arg Asn Asn Glu Tyr Arg Pro Thr

275 280 285Ser Ser Asp Thr Gly Thr Ser Thr Phe Cys Ser Ile Ala Gly Asp Val

290 295 300Lys Leu Thr Met Gln Ala Ala Lys Gly Lys Thr Ile Ser Phe Phe Asp305 310 315 320Ala Ile Arg Thr Ser Thr Lys Lys Thr Gly Thr Gln Ala Thr Ala Tyr

325 330 335Asp Thr Leu Asp Ile Asn Lys Ser Glu Asp Ser Glu Thr Val Asn Ser

340 345 350Ala Phe Thr Gly Thr Ile Leu Phe Ser Ser Glu Leu His Glu Asn Lys

355 360 365Ser Tyr Ile Pro Gln Asn Val Val Leu His Ser Gly Ser Leu Val Leu

370 375 380Lys Pro Asn Thr Glu Leu His Val Ile Ser Phe Glu Gln Lys Glu Gly385 390 395 400Ser Ser Leu Val Met Thr Pro Gly Ser Val Leu Ser Asn Gln Thr Val

405 410 415Ala Asp Gly Ala Leu Val Ile Asn Asn Met Thr Ile Asp Leu Ser Ser

420 425 430Val Glu Lys Asn Gly Ile Ala Glu Gly Asn Ile Phe Thr Pro Pro Glu

435 440 445Leu Arg Ile Ile Asp Thr Thr Thr Ser Gly Ser Gly Gly Thr Pro Ser

450 455 460Thr Asp Ser Glu Ser Asn Gln Asn Ser Asp Asp Thr Lys Glu Gln Asn465 470 475 480Asn Asn Asp Ala Ser Asn Gln Gly Glu Ser Ala Asn Gly Ser Ser Ser

485 490 495Pro Ala Val Ala Ala Ala His Thr Ser Arg Thr Arg Asn Phe Ala Ala

500 505 510Ala Ala Thr Ala Thr Pro Thr Thr Thr Pro Thr Ala Thr Thr Thr Thr

515 520 525Ser Asn Gln Val Ile Leu Gly Gly Glu Ile Lys Leu Ile Asp Pro Asn

530 535 540Gly Thr Phe Phe Gln Asn Pro Ala Leu Arg Ser Asp Gln Gln Ile Ser545 550 555 560Leu Leu Val Leu Pro Thr Asp Ser Ser Lys Met Gln Ala Gln Lys Ile

565 570 575Val Leu Thr Gly Asp Ile Ala Pro Gln Lys Gly Tyr Thr Gly Thr Leu

580 585 590Thr Leu Asp Pro Asp Gln Leu Gln Asn Gly Thr Ile Ser Ala Leu Trp

595 600 605Lys Phe Asp Ser Tyr Arg Gln Trp Ala Tyr Val Pro Arg Asp Asn His

610 615 620Phe Tyr Ala Asn Ser Ile Leu Gly Ser Gln Met Ser Met Val Thr Val625 630 635 640Lys Gln Gly Leu Leu Asn Asp Lys Met Asn Leu Ala Arg Phe Asp Glu

645 650 655Val Ser Tyr Asn Asn Leu Trp Ile Ser Gly Leu Gly Thr Met Leu Ser

660 665 670Gln Val Gly Thr Pro Thr Ser Glu Glu Phe Thr Tyr Tyr Ser Arg Gly

675 680 685Ala Ser Val Ala Leu Asp Ala Lys Pro Ala His Asp Val Ile Val Gly

690 695 700Ala Ala Phe Ser Lys Met Ile Gly Lys Thr Lys Ser Leu Lys Arg Glu705 710 715 720Asn Asn Tyr Thr His Lys Gly Ser Glu Tyr Ser Tyr Gln Ala Ser Val

725 730 735Tyr Gly Gly Lys Pro Phe His Phe Val Ile Asn Lys Lys Thr Glu Lys

740 745 750Ser Leu Pro Leu Leu Leu Gln Gly Val Ile Ser Tyr Gly Tyr Ile Lys

755 760 765His Asp Thr Val Thr His Tyr Pro Thr Ile Arg Glu Arg Asn Gln Gly

770 775 780Glu Trp Glu Asp Leu Gly Trp Leu Thr Ala Leu Arg Val Ser Ser Val785 790 795 800Leu Arg Thr Pro Ala Gln Gly Asp Thr Lys Arg Ile Thr Val Tyr Gly

805 810 815Glu Leu Glu Tyr Ser Ser Ile Arg Gln Lys Gln Phe Thr Glu Thr Glu

820 825 830Tyr Asp Pro Arg Tyr Phe Asp Asn Cys Thr Tyr Arg Asn Leu Ala Ile

835 840 845Pro Met Gly Leu Ala Phe Glu Gly Glu Leu Ser Gly Asn Asp Ile Leu

850 855 860Met Tyr Asn Arg Phe Ser Val Ala Tyr Met Pro Ser Ile Tyr Arg Asn865 870 875 880Ser Pro Thr Cys Lys Tyr Gln Val Leu Ser Ser Gly Glu Gly Gly Glu

885 890 895Ile Ile Cys Gly Val Pro Thr Arg Asn Ser Ala Arg Gly Glu Tyr Ser

900 905 910Thr Gln Leu Tyr Pro Gly Pro Leu Trp Thr LeuTyr Gly Ser Tyr Thr

915 920 925Ile Glu Ala Asp Ala His Thr Leu Ala His Met Met Asn Cys Gly Ala

930 935 940Arg Met Thr Phe945

<210>195

<211>82l

<212>PRT

<213>衣原体属

<400>195Met His His His His His His Glu Ala Ser Ser Ile Gln Asp Gln Ile1 5 10 15Lys Asn Thr Asp Cys Asn Val Ser Lys Val Gly Tyr Ser Thr Ser Gln

20 25 30Ala Phe Thr Asp Met Met Leu Ala Asp Asn Thr Glu Tyr Arg Ala Ala

35 40 45Asp Ser Val Ser Phe Tyr Asp Phe Ser Thr Ser Ser Gly Leu Pro Arg

50 55 60Lys His Leu Ser Ser Ser Ser Glu Ala Ser Pro Thr Thr Glu Gly Val65 70 75 80Ser Ser Ser Ser Ser Gly Glu Asn Thr Glu Asn Ser Gln Asp Ser Ala

85 90 95Pro Ser Ser Gly Glu Thr Asp Lys Lys Thr Glu Glu Glu Leu Asp Asn

100 105 110Gly Gly Ile Ile Tyr Ala Arg Glu Lys Leu Thr Ile Ser Glu Ser Gln

115 120 125Asp Ser Leu Ser Asn Pro Ser Ile Glu Leu His Asp Asn Ser Phe Phe

130 135 140Phe Gly Glu Gly Glu Val Ile Phe Asp His Arg Val Ala Leu Lys Asn145 150 155 160Gly Gly Ala Ile Tyr Gly Glu Lys Glu Val Val Phe Glu Asn Ile Lys

165 170 175Ser Leu Leu Val Glu Val Asn Ile Ser Val Glu Lys Gly Gly Ser Val

180 185 190Tyr Ala Lys Glu Arg Val Ser Leu Glu Asn Val Thr Glu Ala Thr Phe

195 200 205Ser Ser Asn Gly Gly Glu Gln Gly Gly Gly Gly Ile Tyr Ser Glu Gln

210 215 220Asp Met Leu Ile Ser Asp Cys Asn Asn Val His Phe Gln Gly Asn Ala225 230 235 240Ala Gly Ala Thr Ala Val Lys Gln Cys Leu Asp Glu Glu Met Ile Val

245 250 255Leu Leu Thr Glu Cys Val Asp Ser Leu Ser Glu Asp Thr Leu Asp Ser

260 265 270Thr Pro Glu Thr Glu Gln Thr Lys Ser Asn Gly Asn Gln Asp Gly Ser

275 280 285Ser Glu Thr Lys Asp Thr Gln Val Ser Glu Ser Pro Glu Ser Thr Pro

290 295 300Ser Pro Asp Asp Val Leu Gly Lys Gly Gly Gly Ile Tyr Thr Glu Lys305 310 315 320Ser Leu Thr Ile Thr Gly Ile Thr Gly Thr Ile Asp Phe Val Ser Asn

325 330 335Ile Ala Thr Asp Ser Gly Ala Gly Val Phe Thr Lys Glu Asn Leu Ser

340 345 350Cys Thr Asn Thr Asn Ser Leu Gln Phe Leu Lys AsrnSer Ala Gly Gln

355 360 365His Gly Gly Gly Ala Tyr Val Thr Gln Thr Met Ser Val Thr Asn Thr

370 375 380Thr Ser Glu Ser Ile Thr Thr Pro Pro Leu Val Gly Glu Val Ile Phe385 390 395 400Ser Glu Asn Thr Ala Lys Gly His Gly Gly Gly Ile Cys Thr Asn Lys

405 410 415Leu Ser Leu Ser Asn Leu Lys Thr Val Thr Leu Thr Lys Asn Ser Ala

420 425 430Lys Glu Ser Gly Gly Ala Ile Phe Thr Asp Leu Ala Ser Ile Pro Thr

435 440 445Thr Asp Thr Pro Glu Ser Ser Thr Pro Ser Ser Ser Ser Pro Ala Ser

450 455 460Thr Pro Glu Val Val Ala Ser Ala Lys Ile Asn Arg Phe Phe Ala Ser465 470 475 480Thr Ala Glu Pro Ala Ala Pro Ser Leu Thr Glu Ala Glu Ser Asp Gln

485 490 495Thr Asp Gln Thr Glu Thr Ser Asp Thr Asn Ser Asp Ile Asp Val Ser

500 505 510Ile Glu Asn Ile Leu Asn Val Ala Ile Asn Gln Asn Thr Ser Ala Lys

515 520 525Lys Gly Gly Ala Ile Tyr Gly Lys Lys Ala Lys Leu Ser Arg Ile Asn

530 535 540Asn Leu Glu Leu Ser Gly Asn Ser Ser Gln Asp Val Gly Gly Gly Leu545 550 555 560Cys Leu Thr Glu Ser Val Glu Phe Asp Ala Ile Gly Ser Leu Leu Ser

565 570 575His Tyr Asn Ser Ala Ala Lys Glu Gly Gly Val Ile His Ser Lys Thr

580 585 590Val Thr Leu Ser Asn Leu Lys Ser Thr Phe Thr Phe Ala Asp Asn Thr

595 600 605Val Lys Ala Ile Val Glu Ser Thr Pro Glu Ala Pro Glu Glu Ile Pro

610 615 620Pro Val Glu Gly Glu Glu Ser Thr Ala Thr Glu Asn Pro Asn Ser Asn625 630 635 640Thr Glu Gly Ser Ser Ala Asn Thr Asn Leu Glu Gly Ser Gln Gly Asp

645 650 655Thr Ala Asp Thr Gly Thr Gly Val Val Asn Asn Glu Ser Gln Asp Thr

660 665 670Ser Asp Thr Gly Asn Ala Glu Ser Gly Glu Gln Leu Gln Asp Ser Thr

675 680 685Gln Ser Asn Glu Glu Asn Thr Leu Pro Asn Ser Ser Ile Asp Gln Ser

690 695 700Asn Glu Asn Thr Asp Glu Ser Ser Asp Ser His Thr Glu Glu Ile Thr705 710 715 720Asp Glu Ser Val Ser Ser Ser Ser Lys Ser Gly Ser Ser Thr Pro Gln

725 730 735Asp Gly Gly Ala Ala Ser Ser Gly Ala Pro Ser Gly Asp Gln Ser Ile

740 745 750Ser Ala Asn Ala Cys Leu Ala Lys Ser Tyr Ala Ala Ser Thr Asp Ser

755 760 765Ser Pro Val Ser Asn Ser Ser Gly Ser Asp Val Thr Ala Ser Ser Asp

770 775 780Asn Pro Asp Ser Ser Ser Ser Gly Asp Ser Ala Gly Asp Ser Glu Gly785 790 795 800Pro Thr Glu Pro Glu Ala Gly Ser Thr Thr Glu Thr Pro Thr Leu Ile

805 810 815Gly Gly Gly Ala Ile

820

<210>196

<211>525

<212>PRT

<213>衣原体属

<400>196Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

50 55 60Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu Gly Ile Ser Thr65 70 75 80Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile Asn Ser Ala Thr

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Pro Leu Val Pro Arg Gly Ser

130 135 140Pro Leu Pro Val Gly Asn Pro Ala Glu Pro Ser Leu Leu Ile Asp Gly145 150 155 160Thr Met Trp Glu Gly Ala Ser Gly Asp Pro Cys Asp Pro Cys Ala Thr

165 170 175Trp Cys Asp Ala Ile Ser Ile Arg Ala Gly Tyr Tyr Gly Asp Tyr Val

180 185 190Phe Asp Arg Val Leu Lys Val Asp Val Asn Lys Thr Phe Ser Gly Met

195 200 205Ala Ala Thr Pro Thr Gln Ala Ile Gly Asn Ala Ser Asn Thr Asn Gln

210 215 220Pro Glu Ala Asn Gly Arg Pro Asn Ile Ala Tyr Gly Arg His Met Gln225 230 235 240Asp Ala Glu Trp Phe Ser Asn Ala Ala Phe Leu Ala Leu Asn Ile Trp

245 250 255Asp Arg Phe Asp Ile Phe Cys Thr Leu Gly Ala Ser Asn Gly Tyr Phe

260 265 270Lys Ala Ser Ser Ala Ala Phe Asn Leu Val Gly Leu Ile Gly Phe Ser

275 280 285Ala Ala Ser Ser Ile Ser Thr Asp Leu Pro Met Gln Leu Pro Asn Val

290 295 300Gly Ile Thr Gln Gly Val Val Glu Phe Tyr Thr Asp Thr Ser Phe Ser305 310 315 320Trp Ser Val Gly Ala Arg Gly Ala Leu Trp Glu Cys Gly Cys Ala Thr

325 330 335Leu Gly Ala Glu Phe Gln Tyr Ala Gln Ser Asn Pro Lys Ile Glu Met

340 345 350Leu Asn Val Thr Ser Ser Pro Ala Gln Phe Val Ile His Lys Pro Arg

355 360 365Gly Tyr Lys Gly Ala Ser Ser Asn Phe Pro Leu Pro Ile Thr Ala Gly

370 375 380Thr Thr Glu Ala Thr Asp Thr Lys Ser Ala Thr Ile Lys Tyr His Glu385 390 395 400Trp Gln Val Gly Leu Ala Leu Ser Tyr Arg Leu Asn Met Leu Val Pro

405 410 415Tyr Ile Gly Val Asn Trp Ser Arg Ala Thr Phe Asp Ala Asp Thr Ile

420 425 430Arg Ile Ala Gln Pro Lys Leu Lys Ser Glu Ile Leu Asn Ile Thr Thr

435 440 445Trp Asn Pro Ser Leu Ile Gly Ser Thr Thr Ala Leu Pro Asn Asn Ser

450 455 460Gly Lys Asp Val Leu Ser Asp Val Leu Gln Ile Ala Ser Ile Gln Ile465 470 475 480Asn Lys Met Lys Ser Arg Lys Ala Cys Gly Val Ala Val Gly Ala Thr

485 490 495Leu Ile Asp Ala Asp Lys Trp Ser Ile Thr Gly Glu Ala Arg Leu Ile

500 505 510Asn Glu Arg Ala Ala His Met Asn Ala Gln Phe Arg Phe

515 520 525

<210>197

<211>43

<212>DNA

<213>衣原体属

<400>197gataggcgcg ccgcaatcat gaaatttatg tcagctactg ctg 43

<210>198

<211>34

<212>DNA

<213>衣原体属

<400>198cagaacgcgt ttagaatgtc atacgagcac cgca 34

<210>199

<211>6

<212>DNA

<213>衣原体属

<400>199gcaatc 6

<210>200

<211>34

<212>DNA

<213>衣原体属

<400>200tgcaatcatg agttcgcaga aagatataaa aagc 34

<210>201

<211>38

<212>DNA

<213>衣原体属

<400>201cagagctagc ttaaaagatc aatcgcaatc cagtattc 38

<210>202

<211>5

<212>DNA

<213>衣原体属

<400>202caatc 5

<210>203

<211>31

<212>DNA

<213>衣原体属

<400>203tgcaatcatg aaaaaagcgt ttttcttttt c 31

<210>204

<211>31

<212>DNA

<213>衣原体属

<400>204cagaacgcgt ctagaatcgc agagcaattt c 31

<210>205

<211>30

<212>DNA

<213>衣原体属

<400>205gtgcaatcat gattcctcaa ggaatttacg 30

<210>206

<211>31

<212>DNA

<213>衣原体属

<400>206cagaacgcgt ttagaaccgg actttacttc c 31

<210>207

<211>50

<212>DNA

<213>衣原体属

<400>207cagacatatg catcaccatc accatcacga ggcgagctcg atccaagatc 50

<210>208

<211>40

<212>DNA

<213>衣原体属

<400>208cagaggtacc tcagatagca ctctctccta ttaaagtagg 40

<210>209

<211>55

<212>DNA

<213>衣原体属

<400>209cagagctagc atgcatcacc atcaccatca cgttaagatt gagaacttct ctggc 55

<210>210

<211>35

<212>DNA

<213>衣原体属

<400>210cagaggtacc ttagaatgtc atacgagcac cgcag 35

<210>211

<211>36

<212>DNA

<213>衣原体属

<400>211cagacatatg catcaccatc accatcacgg gttagc 36

<210>212

<211>35

<212>DNA

<213>衣原体属

<400>212cagaggtacc tcagctcctc cagcacactc tcttc 35

<210>213

<211>51

<212>DNA

<213>衣原体属

<400>213cagagctagc catcaccatc accatcacgg tgctatttct tgcttacgtg g 51

<210>214

<211>38

<212>DNA

<213>衣原体属

<400>214cagaggtact taaaagatca atcgcaatcc agtattcg 38

<210>215

<211>48

<212>DNA

<213>衣原体属

<400>215cagaggatcc acatcaccat caccatcacg gactagctag agaggttc 48

<210>216

<211>31

<212>DNA

<213>衣原体属

<400>216cagagaattc ctagaatcgc agagcaattt c 31

<210>217

<211>7

<212>DNA

<213>衣原体属

<400>217tgcaatc 7

<210>218

<211>22

<212>PRT

<213>衣原体属

<400>218Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Asp Ser Ser Leu1 5 10 15Val Pro Ser Ser Asp Pro

20

<210>219

<211>51

<212>DNA

<213>衣原体属

<400>219cagaggtacc gcatcaccat caccatcaca tgattcctca aggaatttac g 51

<210>220

<211>33

<212>DNA

<213>衣原体属

<400>220cagagcggcc gcttagaacc ggactttact tcc 33

<210>221

<211>24

<212>PRT

<213>衣原体属

<400>221Met Ala Ser Met Thr Gly Gly Gln Gln Asn Gly Arg Asp Ser Ser Leu1 5 10 15Val Pro His His His His His His

20

<210>222

<211>46

<212>DNA

<213>衣原体属

<400>222agagctagc catcaccatc accatcacct ctttggccag gatccc 46

<210>223

<211>30

<212>DNA

<213>衣原体属

<400>223agaactagt ctagaacctg taagtggtcc 30

<210>224

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>224Met Ser Gln Lys Asn Lys Asn Ser Ala Phe Met His Pro Val Asn Ile1 5 10 15Ser Thr Asp Leu

20

<210>225

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>225Lys Asn Ser Ala Phe Met His Pro Val Asn Ile Ser Thr Asp Leu Ala1 5 10 15Val Ile Val Gly

20

<210>226

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>226His Pro Val Asn Ile Ser Thr Asp Leu Ala Val Ile Val Gly Lys Gly1 5 10 15Pro Met Pro Arg

20

<210>227

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>227Ser Thr Asp Leu Ala Val Ile Val Gly Kys Gly Pro Met Pro Arg Thr1 5 10 15Glu Ile Val Lys

20

<210>228

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>228Val Ile Val Gly Lys Gly Pro Met Pro Arg Thr Glu Ile Val Lys Lys1 5 10 15Val Trp Glu Tyr

20

<210>229

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>229Gly Pro Met Pro Arg Thr Glu Ile Val Lys Lys Val Trp Glu Tyr Ile1 5 10 15Lys Lys His Asn

20

<210>230

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>230Ile Lys Lys His Asn Cys Gln Asp Gln Lys Asn Lys Arg Asn Ile Leu1 5 10 15Pro Asp Ala Asn

20

<210>231

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>231Asn Cys Gln Asp Gln Lys Asn Lys Arg Asn Ile Leu Pro Asp Ala Asn1 5 10 15Leu Ala Lys Val

20

<210>232

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>232Lys Asn Lys Arg Asn Ile Leu Pro Asp Ala Asn Leu Ala Lys Val Phe1 5 10 15Gly Ser Ser Asp

20

<210>233

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>233Ile Leu Pro Asp Ala Asn Leu Ala Lys Val Phe Gly Ser Ser Asp Pro1 5 10 15Ile Asp Met Phe

20

<210>234

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>234Asn Leu Ala Lys Val Phe Gly Ser Ser Asp Pro Ile Asp Met Phe Gln1 5 10 15Met Thr Lys Ala

20

<210>235

<211>22

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>235Phe Gly Ser Ser Asp Pro Ile Asp Met Phe Gln Met Thr Lys Ala Leu1 5 10 15Ser Lys His Ile Val Lys

20

<210>236

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>236Val Glu Ile Thr Gln Ala Val Pro Lys Tyr Ala Thr Val Gly Ser Pro1 5 10 15Tyr Pro Val Glu

20

<210>237

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>237Ala Val Pro Lys Tyr Ala Thr Val Gly Ser Pro Tyr Pro Val Glu Ile1 5 10 15Thr Ala Thr Gly

20

<210>238

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>238Ala Thr Val Gly Ser Pro Tyr Pro Val Glu Ile Thr Ala Thr Gly Lys1 5 10 15Arg Asp Cys Val

20

<210>239

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>239Pro Tyr Pro Val Glu Ile Thr Ala Thr Gly Lys Arg Asp Cys Val Asp1 5 10 15Val Ile Ile Thr

20

<210>240

<211>21

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>240Ile Thr Ala Thr Gly Lys Arg Asp Cys Val Asp Val Ile Ile Thr Gln1 5 10 15Gln Leu Pro Cys Glu

20

<210>241

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>241Lys Arg Asp Cys Val Asp Val Ile Ile Thr Gln Gln Leu Pro Cys Glu1 5 10 15Ala Glu Phe Val

20

<210>242

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>242Asp Val Ile Ile Thr Gln Gln Leu Pro Cys Glu Ala Glu Phe Val Arg1 5 10 15Ser Asp Pro Ala

20

<210>243

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>243Thr Gln Gln Leu Pro Cys Glu Ala Glu Phe Val Arg Ser Asp Pro Ala1 5 10 15Thr Thr Pro Thr

20

<210>244

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>244Cys Glu Ala Glu Phe Val Arg Ser Asp Pro Ala Thr Thr Pro Thr Ala1 5 10 15Asp Gly Lys Leu

20

<210>245

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>245Val Arg Ser Asp Pro Ala Thr Thr Pro Thr Ala Asp Gly Lys Leu Val1 5 10 15Trp Lys Ile Asp

20

<210>246

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>246Ala Thr Thr Pro Thr Ala Asp Gly Lys Leu Val Trp Lys Ile Asp Arg1 5 10 15Leu Gly Gln Gly

20

<210>247

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>247Ala Asp Gly Lys Leu Val Trp Lys Ile Asp Arg Leu Gly Gln Gly Glu1 5 10 15Lys Ser Lys Ile

20

<210>248

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>248Val Trp Lys Ile Asp Arg Leu Gly Gln Gly Glu Lys Ser Lys Ile Thr1 5 10 15Val Trp Val Lys

20

<210>249

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>249Arg Leu Gly Gln Gly Glu Lys Ser Lys Ile Thr Val Trp Val Lys Pro1 5 10 15Leu Lys Glu Gly

20

<210>250

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>250Gly Glu Lys Ser Lys Ile Thr Val Trp Val Lys ProLeu Lys Glu Gly1 5 10 15Cys Cys Phe Thr

20

<210>251

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>251Gly Glu Lys Ser Lys Ile Thr Val Trp Val Lys Pro Leu Lys Glu Gly1 5 10 15

<210>252

<211>12

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>252Lys Ile Thr Val Trp Val Lys Pro Leu Lys Glu Gly1 5 10

<210>253

<211>16

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>253Gly Asp Lys Cys Lys Ile Thr Val Trp Val Lys Pro Leu Lys Glu Gly1 5 10 15

<210>254

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>254Thr Glu Tyr Pro Leu Leu Ala Asp Pro Ser Phe Lys Ile Ser Glu Ala1 5 10 15Phe Gly Val Leu

20

<210>255

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>255Leu Ala Asp Pro Ser Phe Lys Ile Ser Glu Ala Phe Gly Val Leu Asn1 5 10 15Pro Glu Gly Ser

20

<210>256

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>256Phe Lys Ile Ser Glu Ala Phe Gly Val Leu Asn Pro Glu GlV Ser Leu1 5 10 15Ala Leu Arg Ala

20

<210>257

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>257Ala Phe Gly Val Leu Asn Pro Glu Gly Ser Leu Ala Leu Arg Ala Thr1 5 10 15Phe Leu Ile Asp

20

<210>258

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>258Asn Pro Glu Gly Ser Leu Ala Leu Arg Ala Thr Phe Leu Ile Asp Lys1 5 10 15His Gly Val Ile

20

<210>259

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>259Leu Ala Leu Arg Ala Thr Phe Leu Ile Asp Lys His Gly Val Ile Arg1 5 10 15His Ala Val Ile

20

<210>260

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>260Thr Phe Leu Ile Asp Lys His Gly Val Ile Arg His Ala Val Ile Asn1 5 10 15Asp Leu Pro Leu

20

<210>261

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>261Lys His Gly Val Ile Arg His Ala Val Ile Asn Asp Leu Pro Leu Gly1 5 10 15Arg Ser Ile Asp

20

<210>262

<211>20

<212>PRT

<213>人工序列

<220>

<223>实验室制

<400>262Arg His Ala Val Ile Asn Asp Leu Pro Leu Gly Arg Ser Ile Asp Glu1 5 10 15Glu Leu Arg Ile

20

<210>263

<211>897

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>604

<223>n＝A，T，C或G

<400>263atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggagt ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcgnaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>264

<211>298

<212>PRT

<213>衣原体属

<220>

<221>VARIANT

<222>202

<223>Xaa＝任何氨基酸

<400>264Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Val Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Xaa Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Pro Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>265

<211>897

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>604

<223>n＝A，T，C或G

<400>265atggcttcta tatgcggacg tttagggtct ggtacaggga atgctctaaa agcttttttt 60acacagccca acaataaaat ggcaagggta gtaaataaga cgaagggaat ggataagact 120attaaggttg ccaagtctgc tgccgaattg accgcaaata ttttggaaca agctggaggc 180gcgggctctt ccgcacacat tacagcttcc caagtgtcca aaggattagg ggatgcgaga 240actgttgtcg ctttagggaa tgcctttaac ggagcgttgc caggaacagt tcaaagtgcg 300caaagcttct tctctcacat gaaagctgct agtcagaaaa cgcaagaagg ggatgagggg 360ctcacagcag atctttgtgt gtctcataag cgcagagcgg ctgcggctgt ctgtagcatc 420atcggaggaa ttacctacct cgcgacattc ggagctatcc gtccgattct gtttgtcaac 480aaaatgctgg caaaaccgtt tctttcttcc caaactaaag caaatatggg atcttctgtt 540agctatatta tggcggctaa ccatgcagcg tctgtggtgg gtgctggact cgctatcagt 600gcgnaaagag cagattgcga agcccgctgc gctcgtattg cgagagaaga gtcgttactc 660gaagtgccgg gagaggaaaa tgcttgcgag aagaaagtcg ctggagagaa agccaagacg 720ttcacgcgca tcaagtatgc actcctcact atgctcgaga agtttttgga atgcgttgcc 780gacgttttca aattggtgcc gctgcctatt acaatgggta ttcgtgcgat tgtggctgct 840ggatgtacgt tcacttctgc aattattgga ttgtgcactt tctgcgccag agcataa 897

<210>266

<211>298

<212>PRT

<213>衣原体属

<220>

<221>VARIANT

<222>202

<223>Xaa＝任何氨基酸

<400>266Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu1 5 10 15Lys Ala Phe Phe Thr Gln Pro Asn Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Ile Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu Cys Val Ser

115 120 125His Lys Arg Arg Ala Ala Ala Ala Val Cys Ser Ile Ile Gly Gly Ile

165 170 175Gly Ser Ser Val Ser Tyr Ile Met Ala Ala Asn His Ala Ala Ser Val

180 185 190Val Gly Ala Gly Leu Ala Ile Ser Ala Xaa Arg Ala Asp Cys Glu Ala

195 200 205Arg Cys Ala Arg Ile Ala Arg Glu Glu Ser Leu Leu Glu Val Pro Gly

245 250 255Glu Cys Val Ala Asp Val Phe Lys Leu Val Pro Leu Pro Ile Thr Met

260 265 270Gly Ile Arg Ala Ile Val Ala Ala Gly Cys Thr Phe Thr Ser Ala Ile

275 280 285Ile Gly Leu Cys Thr Phe Cys Ala Arg Ala

290 295

<210>267

<211>680

<212>DNA

<213>衣原体属

<400>267tctatatcca tattgatagg aaaaaacgtc gcagaaagat tttagctatg acgtttatcc 60gagctttagg atattcaaca gatgcagata ttattgaaga gttcttttct gtagaggagc 120gttccttacg ttcagagaag gattttgtcg cgttagttgg taaagtttta gctgataacg 180tagttgatgc ggattcttca ttagtttacg ggaaagctgg agagaagcta agtactgcta 240tgctaaaacg catcttagat acgggagtcc aatctttgaa gattgctgtt ggcgcagatg 300aaaatcaccc aattattaag atgctcgcaa aagatcctac ggattcttac gaagctgctc 360ttaaagattt ttatcgcaga ttacgaccag gagagcctgc aactttagct aatgctcgat 420ccacaattat gcgtttattc ttcgatgcta aacgttataa tttaggccgc gttggacgtt 480ataaattaaa taaaaaatta ggcttcccat tagacgacga aacattatct caagtgactt 540tgagaaaaga agatgttatc ggcgcgttga aatatttgat tcgtttgcga atgggcgatg 600agaagacatc tatcgatgat attgaccatt tggcaaaccg acgagttcgc tctgttggag 660aactaattca gaatcactgt 680

<210>268

<211>359

<212>DNA

<213>衣原体属

<400>268cttatgttct ggagaatgtt gcaacaacat attaatcgaa ccagctcctc ctagtaacat 60agaaaccaag cccttttgag aaaaaacctg tacttcgcat cctttagcca tttgttgaat 120agctcctaac aaagagctaa ttttttcctc ttccttgttt ttctgaggcg ctgtggactc 180taaatatagc aagtgctctt ggaacacctc atcaacaatc gcttgtccta gattaggtat 240agagactgtc tctccatcaa ttaaatggag tttcaaagta atatcccctt ccgtccctcc 300atcacaagac tctatgaaag ctatctgatt ccatcgagca gaaatgtatg gggaaatac 359

<210>269

<211>124

<212>DNA

<213>衣原体属

<400>269gatcgaatca attgagggag ctcattaaca agaatagctg cagtttcttt gcgttcttct 60ggaataacaa gaaataggta atcggtacca ttgatagaac gaacacgaca aatcgcagaa 120ggtt 124

<210>270

<211>219

<212>DNA

<213>衣原体属

<400>270gatcctgttg ggcctagtaa taatacgttg gatttcccat aactcacttg tttatcctgc 60ataagagcac ggatacgctt atagtggtta tagacggcaa ccgaaatcgt ttttttcgcg 120cgctcttgtc caatgacata agagtcgatg tggcgtttga tttctttagg ggttaacact 180ctcagacttg ttggagagct tgtggaagat gttgcgatc 219

<210>271

<211>511

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>447

<223>n＝A，T，C或G

<400>271ggatccgaat tcggcacgag gagaaaatat aggaggttcc akcatcggaa gatctaatag 60acaaagaggt tttggcatag atggctcctc cttgtacgtt caacgatgat tgggagggat 120tgttatcgat agcttggttc ccagagaact gacaagtccc gctacattga gagaatgtaa 180cctgttctcc atagatagct cctcctacta cacctgaata agttggtgtt gctggagatg 240atggtgcggc tgctgcggct gcttgtaggg aagcagcagc tgcagcaggt gctgaagctg 300ttgttgcgac tcctgtggat gaggagtttg ctttgttgtt cgagaaagag aagcctgatt 360tcagattaga aatatttaca gttttagcat gtaagcctcc accttctttc ccaacaaggt 420tctctgttac agataaggag actagangca tctagtttta aagatttttt acagcagata 480cctccaccta tctctgtagc ggagttctca g 511

<210>272

<211>598

<212>DNA

<213>衣原体属

<400>272ctcttcctct cctcaatcta gttctggagc aactacagtc tccgactcag gagactctag 60ctctggctca aactcggata cctcaaaaac agttccagtc acagctaaag gcggtgggct 120ttatactgat aagaatcttt cgattactaa catcacagga attatcgaaa ttgcaaataa 180caaagcgaca gatgttggag gtggtgctta cgtaaaagga acccttactt gtaaaaactc 240tcaccgtcta caatttttga aaaactcttc cgataaacaa ggtggaggaa tctacggaga 300agacaacatc accctatcta atttgacagg gaagactcta ttccaagaga atactgccaa 360aaaagagggc ggtggactct tcataaaagg tacagataaa gctcttacaa tgacaggact 420ggatagtttc tgtttaatta ataacacatc agaaaaacat ggtggtggga gcctttgtta 480ccaaagaaat ctctcagact tacacctctt gatgtggaaa caattccagg aatcacgcct 540gtacatggtg aaacagtcat tactggcaat aaatctacag gaggtaatgg tggagggc 598

<210>273

<211>126

<212>DNA

<213>衣原体属

<400>273ggatccgaat tcggcacgag atgagcctta tagtttaaca aaagcttctc acattccttc 60gatagctttt tattagccgt ttttagcatc ctaatgagat ctcctcgttc gtaacaaata 120cgagag 126

<210>274

<211>264

<212>DNA

<213>衣原体属

<400>274ggatccgaat tcggcacgag ctcttttaaa tcttaattac aaaaagacaa attaattcaa 60tttttcaaaa aagaatttaa acattaattg ttgtaaaaaa acaatattta ttctaaaata 120ataaccatag ttacggggga atctctttca tggtttattt tagagctcat caacctaggc 180atacgcctaa aacatttcct ttgaaagttc accattcgtt ctccgataag catcctcaaa 240ttgctaaagc tatgtggatt acgg 264

<210>275

<211>359

<212>DNA

<213>衣原体属

<400>275ggatccgaat tcggcacgag ataaaacctg aaccacaaca aagatctaaa acttcttgat 60tttcagctgc aaattctttt agataaatat caaccatttc ttcagtttca tatcttggaa 120ttaaaacttg ttctcttaaa ttaattctag tatttaagta ttcaacatag cccattatta 180attgaattgg ataattttgc cttaataatt cacattcttt ttcagtaatt ttaggttcta 240aaccgtaccg ctttttttct aaaattaatg tttcttcatt attcatttta taagccactt 300tcctttattt tttgattttg ttcttctgtt agtaatgctt caataatagt taataattt 359

<210>276

<211>357

<212>DNA

<213>衣原体属

<400>276aaaacaattg atataatttt ttttttcata acttccagac tcctttctag aaaagtcttt 60atgggtagta gtgactctaa cgttttttat tattaagacg atccccggag atccttttaa 120tgatgaaaac ggaaacatcc tttcgccaga aactttagca ctattaaaga atcgttacgg 180gttagataag cctttattca cccagtatct tatctatttg aaatgtctgc taacactaga 240tttcggggaa tctcttatct acaaagatcg aaatctcagc attattgctg ccgctcttcc 300atcttccgct attcttggac ttgaaagctt gtgtttactc gtgccgaatt cggatcc 357

<210>277

<211>505

<212>DNA

<213>衣原体属

<400>277ggatccgaat tcggcacgag ctcgtgccga ttgcttgctt cagtcacccc atcggtatag 60agcactaaaa gagactcctc ttcaagaacg agagtgtaag cagggtgagg aggaacttca 120ggtaaaaatc ctaaggccat accaggatgc gacaggaaag agatatctcc attaggagct 180cggagacacg ctgggttgtg gccacaagaa tagtattcta gttctcgtgt tgcgtaatga 240taacaataaa tgcatagtgt tacaaacatc ccagattcag ctgtctgttg atagaagaga 300gcagctgttt gttgaacggc ttcttgaata gaggagagct cactcaaaaa ggtatgtaac 360atgtttttca ggaataagga gtaggcgcac gcattgactc ctttcccgga agcatcagca 420acgattagaa agagtttagc ttggggacct tcgcctataa caaagatatc aaagaaatct 480cctcctaccg taactgcagg aatat 505

<210>278

<211>407

<212>DNA

<213>衣原体属

<400>278ggatccgaat tcggcacgag aactactgag caaattgggt atccaacttc ctctttacga 60aagaaaaaca gaaggcattc tccataccaa gatttgttgc atcgacaata aaactccaat 120ctttggctct gctaactgga gcggtgctgg tatgattaaa aactttgaag acctattcat 180ccttcgccca attacagaga cacagcttca ggcctttatg gacgtctggt ctcttctaga 240aacaaatagc tcctatctgt ccccagagag cgtgcttacg gcccctactc cttcaagtag 300acctactcaa caagatacag attctgatga cgaacaaccg agtaccagcc agcaagctat 360ccgtatgaga aaataggatt agggaaacaa aacgacagca aaccaca 407

<210>279

<211>351

<212>DNA

<213>衣原体属

<400>279ctcgtgccgc ttacaggagg cttgtatcct ttaaaataga gtttttctta tgaccccatg 60tggcgatagg ccgggtctag cgccgatagt agaaatatcg gttggttttt gtccttgagg 120ggatcgtata ctttttcaaa gtatggtccc cgtatcgatt atctggaggc tcttatgtct 180ttttttcata ctagaaaata taagcttatc ctcagaggac tcttgtgttt agcaggctgt 240ttcttaatga acagctgttc ctctagtcga ggaaatcaac ccgctgatga gagcatctat 300gtcttgtcta tgaatcgcat gatttgtgat tctcgtgccg aattcggatc c 351

<210>280

<211>522

<212>DNA

<213>衣原体属

<400>280ggatccgaat tcggcacgag cagaggaaaa aggcgatact cctcttgaag atcgtttcac 60agaagatctt tccgaagtct ctggagaaga ttttcgagga ttgaaaaatt cgttcgatga 120tgattcttct tctgacgaaa ttctcgatgc gctcacaagt aaattttctg atcccacaat 180aaaggatcta gctcttgatt atctaattca aatagctccc tctgatggga aacttaagtc 240cgctctcatt caggcaaagc atcaactgat gagccagaat cctcaggcga ttgttggagg 300acgcaatgtt ctgttagctt cagaaacctt tgcttccaga gcaaatacat ctccttcatc 360gcttcgctcc ttatatttcc aagtaacctc atccccctct aattgcgcta atttacatca 420aatgcttgct tcttactcgc catcagagaa aaccgctgtt atggagtttc tagtgaatgg 480catggtagca gatttaaaat cggagggccc ttccattcct cc 522

<210>281

<211>577

<212>DNA

<213>衣原体属

<400>281ggatccgaat tcggcacgag atgcttctat tacaattggt ttggatgcgg aaaaagctta 60ccagcttatt ctagaaaagt tgggagatca aattcttggt ggaattgctg atactattgt 120tgatagtaca gtccaagata ttttagacaa aatcacaaca gacccttctc taggtttgtt 180gaaagctttt aacaactttc caatcactaa taaaattcaa tgcaacgggt tattcactcc 240caggaacatt gaaactttat taggaggaac tgaaatagga aaattcacag tcacacccaa 300aagctctggg agcatgttct tagtctcagc agatattatt gcatcaagaa tggaaggcgg 360cgttgttcta gctttggtac gagaaggtga ttctaagccc tacgcgatta gttatggata 420ctcatcaggc gttcctaatt tatgtagtct aagaaccaga attattaata caggattgac 480tccgacaacg tattcattac gtgtaggcgg tttagaaagc ggtgtggtat gggttaatgc 540cctttctaat ggcaatgata ttttaggaat aacaaat 577

<210>282

<211>607

<212>DNA

<213>衣原体属

<400>282actmatcttc cccgggctcg agtgcggccg caagcttgtc gacggagctc gatacaaaaa 60tgtgtgcgtg tgaaccgctt cttcaaaagc ttgtcttaaa agatattgtc tcgcttccgg 120attagttaca tgtttaaaaa ttgctagaac aatattattc ccaaccaagc tctctgcggt 180gctgaaaaaa cctaaattca aaagaatgac tcgccgctca tcttcagaaa gacgatccga 240cttccataat tcgatgtctt tccccatggg gatctctgta gggagccagt tatttgcgca 300gccattcaaa taatgttccc aagcccattt gtacttaata ggaacaagtt ggttgacatc 360gacctggttg cagttcacta gacgcttgct atttagatta acgcgtttct gttttccatc 420taaaatatct gcttgcataa gaaccgttaa ttttattgtt aatttatatg attaattact 480gacatgcttc acacccttct tccaaagaac agacaggtgc tttcttcgct ctttcaacaa 540taattcctgc cgaagcagac ttattcttca tccaacgagg ctgaattcct ctcttattaa 600tatctac 607

<210>283

<211>1077

<212>DNA

<213>衣原体属

<400>283ggatccgaat tcggcacgag aagttaacga tgacgatttg ttcctttggt agagaaggag 60caatcgaaac taaatgtgcg agagcatgtg aagactccaa tgcaggaata atcccctcat 120ttctagtaag caggaaaaaa gctcgtaacg cctcttcatc ggtggctaat gtataaaagg 180ctcgtcctga ctcatgcatt tcggcatgat ctggcccaac tgaaggataa tctaatccag 240cggaaatgga gtgagtttgt aatacttgtc catcgtcatc ttgaagaaga tacgaataaa 300atccgtggaa tactccaggt cgccctgttg caaaacgtgc tgcatgtttt cctgaagaaa 360tgcccagtcc tcccccttcc actccaatta attggacttt tggattcggg ataaaatgat 420ggaaaaatcc aatagcgttg gagccacctc cgatacatgc aatcagaata tcaggatctc 480ttcctgcaac tgcatggatt tgctctttca cttcagcgct tataacagac tgaaaaaatc 540gaacgatatc gggataaggt aaaggtccta aggccgatcc taagcaatag tgagtaaatg 600agtgtgttgt tgcccaatct tgtagagctt gattaactgc atctttgagt ccacaagatc 660cttttgttac agaaacgact tcagcaccta aaaagcgcat tttctctaca tttggtttct 720gtcgttccac atcttttgct cccatgtata ctacacaatc taatcctaga taagcacacg 780ctgttgctgt tgctactcca tgttgtcccg cacctgtttc agctacaaca cgtgttttcc 840caagatattt agcaagcaaa cactgaccaa gagcattatt cagtttatgt gctcctgtat 900gcaaaagatc ttcgcgttta agaaatactc tagggccatc aatagctcga gcaaaattct 960taacttcagt cagaggagtt tgtctccccg catagttttt caaaatacaa tctagttcag 1020ataaaaaact ttgctgagtt ttgagaatct cccattccgc ttttagattc tgtatag 1077

<210>284

<211>407

<212>DNA

<213>衣原体属

<400>284ggatccgaat tcggcacgag aactactgag caaattgggt atccaacttc ctctttacga 60aagaaaaaca gaaggcattc tccataccaa gatttgttgc atcgacaata aaactccaat 120ctttggctct gctaactgga gcggtgctgg tatgattaaa aactttgaag acctattcat 180ccttcgccca attacagaga cacagcttca ggcctttatg gacgtctggt ctcttctaga 240aacaaatagc tcctatctgt ccccagagag cgtgcttacg gcccctactc cttcaagtag 300acctactcaa caagatacag attctgatga cgaacaaccg agtaccagcc agcaagctat 360ccgtatgaga aaataggatt agggaaacaa aacgacagca aaccaca 407

<210>285

<211>802

<212>DNA

<213>衣原体属

<400>285ggatccgaat tcggcacgag ttagcttaat gtctttgtca tctctaccta catttgcagc 60taattctaca ggcacaattg gaatcgttaa tttacgtcgc tgcctagaag agtctgctct 120tgggaaaaaa gaatctgctg aattcgaaaa gatgaaaaac caattctcta acagcatggg 180gaagatggag gaagaactgt cttctatcta ttccaagctc caagacgacg attacatgga 240aggtctatcc gagaccgcag ctgccgaatt aagaaaaaaa ttcgaagatc tatctgcaga 300atacaacaca gctcaagggc agtattacca aatattaaac caaagtaatc tcaagcgcat 360gcaaaagatt atggaagaag tgaaaaaagc ttctgaaact gtgcgtattc aagaaggctt 420gtcagtcctt cttaacgaag atattgtctt atctatcgat agttcggcag ataaaaccga 480tgctgttatt aaagttcttg atgattcttt tcaaaataat taacatgcga agctagccga 540ggagtgccgt atgtctcaat ccacttattc tcttgaacaa ttagctgatt ttttgaaagt 600cgagtttcaa ggaaatggag ctactcttct ttccggagtt gaagagatcg aggaagcaaa 660aacggcacac atcacattct tagataatga aaaatatgct aaacatttaa aatcatcgga 720agctggcgct atcatcatat ctcgaacaca gtttcaaaaa tatcgagact tgaataaaaa 780ctttcttatc acttctgagt ct 802

<210>286

<211>588

<212>DNA

<213>衣原体属

<400>286ggatccgaat tcggcacgag gcaatattta ctcccaacat tacggttcca aataagcgat 60aaggtcttct aataaggaag ttaatgtaag aggctttttt attgcttttc gtaaggtagt 120attgcaaccg cacgcgattg aatgatacgc aagccatttc catcatggaa aagaaccctt 180ggacaaaaat acaaaggagg ttcactccta accagaaaaa gggagagtta gtttccatgg 240gttttcctta tatacacccg tttcacacaa ttaggagccg cgtctagtat ttggaataca 300aattgtcccc aagcgaattt tgttcctgtt tcagggattt ctcctaattg ttctgtcagc 360catccgccta tggtaacgca attagctgta gtaggaagat caactccaaa caggtcatag 420aaatcagaaa gctcataggt gcctgcagca ataacaacat tcttgtctga gtgagcgaat 480tgtttaaaag atgggcgatt atgagctacc tcatcagaga ctattttaaa tagatcattt 540tgggtaatca atccttctat agacccatat tcatcaatga taatctcg 588

<210>287

<211>489

<212>DNA

<213>衣原体属

<220>

<221>misc_feature

<222>488

<223>n＝A，T，C或G

<400>287agtgcctatt gttttgcagg ctttgtctga tgatagcgat accgtacgtg agattgctgt 60acaagtagct gttatgtatg gttctagttg cttactgcgc gccgtgggcg atttagcgaa 120aaatgattct tctattcaag tacgcatcac tgcttatcgt gctgcagccg tgttggagat 180acaagatctt gtgcctcatt tacgagttgt agtccaaaat acacaattag atggaacgga 240aagaagagaa gcttggagat ctttatgtgt tcttactcgg cctcatagtg gtgtattaac 300tggcatagat caagctttaa tgacctgtga gatgttaaag gaatatcctg aaaagtgtac 360ggaagaacag attcgtacat tattggctgc agatcatcca gaagtgcagg tagctacttt 420acagatcatt ctgagaggag gtagagtatt ccggtcatct tctataatgg aatcggttct 480cgtgccgnt 489

<210>288

<211>191

<212>DNA

<213>衣原体属

<400>288ggatccgaat tcaggatatg ctgttgggtt atcaataaaa agggttttgc cattttttaa 60gacgactttg tagataacgc taggagctgt agcaataata tcgagatcaa attctctaga 120gattctctca aagatgattt ctaagtgcag cagtcctaaa aatccacagc ggaacccaaa 180tccgagagag t 191

<210>289

<211>515

<212>DNA

<213>衣原体属

<400>289ggatccgaat tcggcacgag gagcgacgtg aaatagtgga atcttcccgt attcttatta 60cttctgcgtt gccttacgca aatggtcctt tgcattttgg acatattacc ggtgcttatt 120tgcctgcaga tgtttatgcg cgttttcaga gactacaagg caaagaggtt ttgtatattt 180gtggttctga tgaatacgga atcgcaatta cccttaatgc agagttggca ggcatggggt 240atcaagaata tgtcgacatg tatcataagc ttcataaaga taccttcaag aaattgggaa 300tttctgtaga tttcttttcc agaactacga acgcttatca tcctgctatt gtgcaagatt 360tctatcgaaa cttgcaggaa cgcggactgg tagagaatca ggtgaccgaa cagctgtatt 420ctgaggaaga agggaagttt ttagcggacc gttatgttgt aggtacttgt cccaagtgtg 480ggtttgatcg agctcgagga gatgagtgtc agcag 515

<210>290

<211>522

<212>DNA

<213>衣原体属

<400>290ggatccgaat tcggcacgag ggaggaatgg aagggccctc cgattktama tctgctacca 60tgccattcac tagaaactcc ataacagcgg ttttctctga tggcgagtaa gaagcaagca 120tttgatgtaa attagcgcaa ttagaggggg atgaggttac ttggaaatat aaggagcgaa 180gcgatgaagg agatgtattt gctctggaag caaaggtttc tgaagctaac agaacattgc 240gtcctccaac aatcgcctga ggattctggc tcatcagttg atgctttgcc tgaatgagag 300cggacttaag tttcccatca gagggagcta tttgaattag ataatcaaga gctagatcct 360ttattgtggg atcagaaaat ttacttgtga gcgcatcgag aatttcgtca gaagaagaat 420catcatcgaa cgaatttttc aatcctcgaa aatcttctcc agagacttcg gaaagatctt 480ctgtgaaacg atcttcaaga ggagtatcgc ctttttccyc tg 522

<210>291

<211>1002

<212>DNA

<213>衣原体属

<400>291atggcgacta acgcaattag atcggcagga agtgcagcaa gtaagatgct gctgccagtt 60gccaaagaac cagcggctgt cagctccttt gctcagaaag ggatttattg tattcaacaa 120ttttttacaa accctgggaa taagttagca aagtttgtag gggcaacaaa aagtttagat 180aaatgcttta agctaagtaa ggcggtttct gactgtgtcg taggatcgct ggaagaggcg 240ggatgcacag gggacgcatt gacctccgcg agaaacgccc agggtatgtt aaaaacaact 300cgagaagttg ttgccttagc taatgtgctc aatggagctg ttccatctat cgttaactcg 360actcagaggt gttaccaata cacacgtcaa gccttcgagt taggaagcaa gacaaaagaa 420agaaaaacgc ctggggagta tagtaaaatg ctattaactc gaggtgatta cctattggca 480gcttccaggg aagcttgtac ggcagtcggt gcaacgactt actcagcgac attcggtgtt 540ttacgtccgt taatgttaat caataaactc acagcaaaac cattcttaga caaagcgact 600gtaggcaatt ttggcacggc tgttgctgga attatgacca ttaatcatat ggcaggagtt 660gctggtgctg ttggcggaat cgcattagaa caaaagctgt tcaaacgtgc gaaggaatcc 720ctatacaatg agagatgtgc cttagaaaac caacaatctc agttgagtgg ggacgtgatt 780ctaagcgcgg aaagggcatt acgtaaagaa cacgttgcta ctctaaaaag aaatgtttta 840actcttcttg aaaaagcttt agagttggta gtggatggag tcaaactcat tcctttaccg 900attacagtgg cttgctccgc tgcaatttct ggagccttga cggcagcatc cgcaggaatt 960ggcttatata gcatatggca gaaaacaaag tctggcaaat aa 1002

<210>292

<211>333

<212>PRT

<213>衣原体属

<400>292Met Ala Thr Asn Ala Ile Arg Ser Ala Gly Ser Ala Ala Ser Lys Met1 5 10 15Leu Leu Pro Val Ala Lys Glu Pro Ala Ala Val Ser Ser Phe Ala Gln

20 25 30Lys Gly Ile Tyr Cys Ile Gln Gln Phe Phe Thr Asn Pro Gly Asn Lys

35 40 45Leu Ala Lys Phe Val Gly Ala Thr Lys Ser Leu Asp Lys Cys Phe Lys

50 55 60Leu Ser Lys Ala Val Ser Asp Cys Val Val Gly Ser Leu Glu Glu Ala65 70 75 80Gly Cys Thr Gly Asp Ala Leu Thr Ser Ala Arg Asn Ala Gln Gly Met

85 90 95Leu Lys Thr Thr Arg Glu Val Val Ala Leu Ala Asn Val Leu Asn Gly

100 105 110Ala Val Pro Ser Ile Val Asn Ser Thr Gln Arg Cys Tyr Gln Tyr Thr

115 120 125Arg Gln Ala Phe Glu Leu Gly Ser Lys Thr Lys Glu Arg Lys Thr Pro

130 135 140Gly Glu Tyr Ser Lys Met Leu Leu Thr Arg Gly Asp Tyr Leu Leu Ala145 150 155 160Ala Ser Arg Glu Ala Cys Thr Ala Val Gly Ala Thr Thr Tyr Ser Ala

165 170 175Thr Phe Gly Val Leu Arg Pro Leu Met Leu Ile Asn Lys Leu Thr Ala

180 185 190Lys Pro Phe Leu Asp Lys Ala Thr Val Gly Asn Phe Gly Thr Ala Val

195 200 205Ala Gly Ile Met Thr Ile Asn His Met Ala Gly Val Ala Gly Ala Val

210 215 220Gly Gly Ile Ala Leu Glu Gln Lys Leu Phe Lys Arg Ala Lys Glu Ser225 230 235 240Leu Tyr Asn Glu Arg Cys Ala Leu Glu Asn Gln Gln Ser Gln Leu Ser

245 250 255Gly Asp Val Ile Leu Ser Ala Glu Arg Ala Leu Arg Lys Glu His Val

260 265 270Ala Thr Leu Lys Arg Asn Val Leu Thr Leu Leu Glu Lys Ala Leu Glu

275 280 285Leu Val Val Asp Gly Val Lys Leu Ile Pro Leu Pro Ile Thr Val Ala

290 295 300Cys Ser Ala Ala Ile Ser Gly Ala Leu Thr Ala Ala Ser Ala Gly Ile305 310 315 320Gly Leu Tyr Ser Ile Trp Gln Lys Thr Lys Ser Gly Lys

325 330

<210>293

<211>7

<212>DNA

<213>衣原体属

<400>293tgcaatc

<210>294

<211>196

<212>PRT

<213>衣原体属

<400>294Thr Met Gly Ser Leu Val Gly Arg Gln Ala Pro Asp Phe Ser Gly Lys

5 10 15Ala Val Val Cys Gly Glu Glu Lys Glu Ile Ser Leu Ala Asp Phe Arg

20 25 30Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Lys Asp Phe Thr Tyr Val

35 40 45Cys Pro Thr Glu Leu His Ala Phe Gln Asp Arg Leu Val Asp Phe Glu

50 55 60Glu His Gly Ala Val Val Leu Gly Cys Ser Val Asp Asp Ile Glu Thr65 70 75 80His Ser Arg Trp Leu Thr Val Ala Arg Asp Ala Gly Gly Ile Glu Gly

85 90 95Thr Glu Tyr Pro Leu Leu Ala Asp Pro Ser Phe Lys Ile Ser Glu Ala

100 105 110Phe Gly Val Leu Asn Pro Glu Gly Ser Leu Ala Leu Arg Ala Thr Phe

115 120 125Leu Ile Asp Lys His Gly Val Ile Arg His Ala Val Ile Asn Asp Leu

130 135 140Pro Leu Gly Arg Ser Ile Asp Glu Glu Leu Arg Ile Leu Asp Ser Leu145 150 155 160Ile Phe Phe Glu Asn His Gly Met Val Cys Pro Ala Asn Trp Arg Ser

165 170 175Gly Glu Arg Gly Met Val Pro Ser Glu Glu Gly Leu Lys Glu Tyr Phe

180 185 190Gln Thr Met Asp

195

<210>295

<211>181

<212>PRT

<213>衣原体属

<400>295Lys Gly Gly Lys Met Ser Thr Thr Ile Ser Gly Asp Ala Ser Ser Leu

5 10 15Pro Leu Pro Thr Ala Ser Cys Val Glu Thr Lys Ser Thr Ser Ser Ser

20 25 30Thr Lys Gly Asn Thr Cys Ser Lys Ile Leu Asp Ile Ala Leu Ala Ile

35 40 45Val Gly Ala Leu Val Val Val Ala Gly Val Leu Ala Leu Val Leu Cys

50 55 60Ala Ser Asn Val Ile Phe Thr Val Ile Gly Ile Pro Ala Leu Ile Ile65 70 75 80Gly Ser Ala Cys Val Gly Ala Gly Ile Ser Arg Leu Met Tyr Arg Ser

85 90 95Ser Tyr Ala Ser Leu Glu Ala Lys Asn Val Leu Ala Glu Gln Arg Leu

100 105 110Arg Asn Leu Ser Glu Glu Lys Asp Ala Leu Ala Ser Val Ser Phe Ile

115 120 125Asn Lys Met Phe Leu Arg Gly Leu Thr Asp Asp Leu Gln Ala Leu Glu

130 135 140Ala Lys Val Met Glu Phe Glu Ile Asp Cys Leu Asp Arg Leu Glu Lys145 150 155 160Asn Glu Gln Ala Leu Leu Ser Asp Val Arg Leu Val Leu Ser Ser Tyr

165 170 175Thr Arg Trp Leu Asp

180

<210>296

<211>124

<212>PRT

<213>衣原体属

<400>296Ile Tyr Glu Val Met Asn Met Asp Leu Glu Thr Arg Arg Ser Phe Ala

5 10 15Val Gln Gln Gly His Tyr Gln Asp Pro Arg Ala Ser Asp Tyr Asp Leu

20 25 30Pro Arg Ala Ser Asp Tyr Asp Leu Pro Arg Ser Pro Tyr Pro Thr Pro

35 40 45Pro Leu Pro Ser Arg Tyr Gln Leu Gln Asn Met Asp Val Glu Ala Gly

50 55 60Phe Arg Glu Ala Val Tyr Ala Ser Phe Val Ala Gly Met Tyr Asn Tyr65 70 75 80Val Val Thr Gln Pro Gln Glu Arg Ile Pro Asn Ser Gln Gln Val Glu

85 90 95Gly Ile Leu Arg Asp Met Leu Thr Asn Gly Ser Gln Thr Phe Ser Asn

100 105 110Leu Met Gln Arg Trp Asp Arg Glu Val Asp Arg Glu

115 120

<210>297

<211>488

<212>PRT

<213>衣原体属

<400>297Lys Gly Ser Leu Pro Ile Leu Gly Pro Phe Leu Asn Gly Lys Met Gly

5 10 15Phe Trp Arg Thr Ser Ile Met Lys Met Asn Arg Ile Trp Leu Leu Leu

20 25 30Leu Thr Phe Ser Ser Ala Ile His Ser Pro Val Arg Gly Glu Ser Leu

35 40 45Val Cys Lys Asn Ala Leu Gln Asp Leu Ser Phe Leu Glu His Leu Leu

50 55 60Gln Val Lys Tyr Ala Pro Lys Thr Trp Lys Glu Gln Tyr Leu Gly Trp65 70 75 80Asp Leu Val Gln Ser Ser Val Ser Ala Gln Gln Lys Leu Arg Thr Gln

85 90 95Glu Asn Pro Ser Thr Ser Phe Cys Gln Gln Val Leu Ala Asp Phe Ile

100 105 110Gly Gly Leu Asn Asp Phe His Ala Gly Val Thr Phe Phe Ala Ile Glu

115 120 125Ser Ala Tyr Leu Pro Tyr Thr Val Gln Lys Ser Ser Asp Gly Arg Phe

130 135 140Tyr Phe Val Asp Ile Met Thr Phe Ser Ser Glu Ile Arg Val Gly Asp145 150 155 160Glu Leu Leu Glu Val Asp Gly Ala Pro Val Gln Asp Val Leu Ala Thr

165 170 175Leu Tyr Gly Ser Asn His Lys Gly Thr Ala Ala Glu Glu Ser Ala Ala

180 185 190Leu Arg Thr Leu Phe Ser Arg Met Ala Ser Leu Gly His Lys Val Pro

195 200 205Ser Gly Arg Thr Thr Leu Lys Ile Arg Arg Pro Phe Gly Thr Thr Arg

210 215 220Glu Val Arg Val Lys Trp Arg Tyr Val Pro Glu Gly Val Gly Asp Leu225 230 235 240Ala Thr Ile Ala Pro Ser Ile Arg Ala Pro Gln Leu Gln Lys Ser Met

245 250 255Arg Ser Phe Phe Pro Lys Lys Asp Asp Ala Phe His Arg Ser Ser Ser

260 265 270Leu Phe Tyr Ser Pro Met Val Pro His Phe Trp Ala Glu Leu Arg Asn

275 280 285His Tyr Ala Thr Ser Gly Leu Lys Ser Gly Tyr Asn Ile Gly Ser Thr

290 295 300Asp Gly Phe Leu Pro Val Ile Gly Pro Val Ile Trp Glu Ser Glu Gly305 310 315 320Leu Phe Arg Ala Tyr Ile Ser Ser Val Thr Asp Gly Asp Gly Lys Ser

325 330 335His Lys Val Gly Phe Leu Arg Ile Pro Thr Tyr Ser Trp Gln Asp Met

340 345 350Glu Asp Phe Asp Pro Ser Gly Pro Pro Pro Trp Glu Glu Phe Ala Lys

355 360 365Ile Ile Gln Val Phe Ser Ser Asn Thr Glu Ala Leu Ile Ile Asp Gln

370 375 380Thr Asn Asn Pro Gly Gly Ser Val Leu Tyr Leu Tyr Ala Leu Leu Ser385 390 395 400Met Leu Thr Asp Arg Pro Leu Glu Leu Pro Lys His Arg Met Ile Leu

405 410 415Thr Gln Asp Glu Val Val Asp Ala Leu Asp Trp Leu Thr Leu Leu Glu

420 425 430Asn Val Asp Thr Asn Val Glu Ser Arg Leu Ala Leu Gly Asp Asn Met

435 440 445Glu Gly Tyr Thr Val Asp Leu Gln Val Ala Glu Tyr Leu Lys Ser Phe

450 455 460Gly Arg Gln Val Leu Asn Cys Trp Ser Lys Gly Asp Ile Glu Leu Ser465 470 475 480Thr Pro Ile Pro Leu Phe Gly Phe

485

<210>298

<211>140

<212>PRT

<213>衣原体属

<400>298Arg Ile Asp Ile Ser Ser Val Thr Phe Phe Ile Gly Ile Leu Leu Ala

5 10 15Val Asn Ala Leu Thr Tyr Ser His Val Leu Arg Asp Leu Ser Val Ser

20 25 30Met Asp Ala Leu Phe Ser Arg Asn Thr Leu Ala Val Leu Leu Gly Leu

35 40 45Val Ser Ser Val Leu Asp Asn Val Pro Leu Val Ala Ala Thr Ile Gly

50 55 60Met Tyr Asp Leu Pro Met Asn Asp Pro Leu Trp Lys Leu Ile Ala Tyr65 70 75 80Thr Ala Gly Thr Gly Gly Ser Ile Leu Ile Ile Gy Ser Ala Ala Gly

85 90 95Val Ala Tyr Met Gly Met Glu Lys Val Ser Phe Gly Trp Tyr Val Lys

100 105 110His Ala Ser Trp Ile Ala Leu Ala Ser Tyr Phe Gly Gly Leu Ala Val

115 120 125Tyr Phe Leu Met Glu Asn Cys Val Ash Leu Phe Val

130 135 140

<210>299

<211>361

<212>PRT

<213>衣原体属

<400>299His Gln Glu Ile Ala Asp Ser Pro Leu Val Lys Lys Ala Glu Glu Gln

5 10 15Ile Asn Gln Ala Gln Gln Asp Ile Gln Thr Ile Thr Pro Ser Gly Leu

20 25 30Asp Ile Pro Ile Val Gly Pro Ser Gly Ser Ala Ala Ser Ala Gly Ser

35 40 45Ala Ala Gly Ala Leu Lys Ser Ser Asn Asn Ser Gly Arg Ile Ser Leu

50 55 60Leu Leu Asp Asp Val Asp Asn Glu Met Ala Ala Ile Ala Met Gln Gly65 70 75 80Phe Arg Ser Met Ile Glu Gln Phe Asrn Val Asn Asn Pro Ala Thr Ala

85 90 95Lys Glu Leu Gln Ala Met Glu Ala Gln Leu Thr Ala Met Ser Asp Gln

100 105 110Leu Val Gly Ala Asp Gly Glu Leu Pro Ala Glu Ile Gln Ala Ile Lys

115 120 125Asp Ala Leu Ala Gln Ala Leu Lys Gln Pro Ser Ala Asp Gly Leu Ala

130 135 140Thr Ala Met Gly Gln Val Ala Phe Ala Ala Ala Lys Val Gly Gly Gly145 150 155 160Ser Ala Gly Thr Ala Gly Thr Val Gln Met Asn Val Lys Gln Leu Tyr

165 170 175Lys Thr Ala Phe Ser Ser Thr Ser Ser Ser Ser Tyr Ala Ala Ala Leu

180 185 190Ser Asp Gly Tyr Ser Ala Tyr Lys Thr Leu Asn Ser Leu Tyr Ser Glu

195 200 205Ser Arg Ser Gly Val Gln Ser Ala Ile Ser Gln Thr Ala Asn Pro Ala

210 215 220Leu Ser Arg Ser Val Ser Arg Ser Gly Ile Glu Ser Gln Gly Arg Ser225 230 235 240Ala Asp Ala Ser Gln Arg Ala Ala Glu Thr Ile Val Arg Asp Ser Gln

245 250 255Thr Leu Gly Asp Val Tyr Ser Arg Leu Gln Val Leu Asp Ser Leu Met

260 265 270Ser Thr Ile Val Ser Asn Pro Gln Ala Asn Gln Glu Glu Ile Met Gln

275 280 285Lys Leu Thr Ala Ser Ile Ser Lys Ala Pro Gln Phe Gly Tyr Pro Ala

290 295 300Val Gln Asn Ser Val Asp Ser Leu Gln Lys Phe Ala Ala Gln Leu Glu305 310 315 320Arg Glu Phe Val Asp Gly Glu Arg Ser Leu Ala Glu Ser Gln Glu Asn

325 330 335Ala Phe Arg Lys Gln Pro Ala Phe Ile Gln Gln Val Leu Val Asn Ile

340 345 350Ala Ser Leu Phe Ser Gly Tyr Leu Ser

355 360

<210>300

<211>207

<212>PRT

<213>衣原体属

<400>300Ser Ser Lys Ile Val Ser Leu Cys Glu Gly Ala Val Ala Asp Ala Arg

5 10 15Met Cys Lys Ala Glu Leu Ile Lys Lys Glu Ala Asp Ala Tyr Leu Phe

20 25 30Cys Glu Lys Ser Gly Ile Tyr Leu Thr Lys Lys Glu Gly Ile Leu Ile

35 40 45Pro Ser Ala Gly Ile Asp Glu Ser Asn Thr Asp Gln Pro Phe Val Leu

50 55 60Tyr Pro Lys Asp Ile Leu Gly Ser Cys Asn Arg Ile Gly Glu Trp Leu65 70 75 80Arg Asn Tyr Phe Arg Val Lys Glu Leu Gly Val Ile Ile Thr Asp Ser

85 90 95His Thr Thr Pro Met Arg Arg Gly Val Leu Gly Ile Gly Leu Cys Trp

100 105 110Tyr Gly Phe Ser Pro Leu His Asn Tyr Ile Gly Ser Leu Asp Cys Phe

115 120 125Gly Arg Pro Leu Gln Met Thr Gln Ser Asn Leu Val Asp Ala Leu Ala

130 135 140Val Ala Ala Val Val Cys Met Gly Glu Gly Asn Glu Gln Thr Pro Leu145 150 155 160Ala Val Ile Glu Gln Ala Pro Asn Met Val Tyr His Ser Tyr Pro Thr

165 170 175Ser Arg Glu Glu Tyr Cys Ser Leu Arg Ile Asp Glu Thr Glu Asp Leu

180 185 190Tyr Gly Pro Phe Leu Gln Ala Val Thr Trp Ser Gln Glu Lys Lys

195 200 205

<210>301

<211>183

<212>PRT

<213>衣原体属

<400>301Ile Pro Pro Ala Pro Arg Gly His Pro Gln Ile Glu Val Thr Phe Asp

5 10 15Ile Asp Ala Asn Gly Ile Leu His Val Ser Ala Lys Asp Ala Ala Ser

20 25 30Gly Arg Glu Gln Lys Ile Arg Ile Glu Ala Ser Ser Gly Leu Lys Glu

34 40 45Asp Glu Ile Gln Gln Met Ile Arg Asp Ala Glu Leu His Lys Glu Glu

50 55 60Asp Lys Gln Arg Lys Glu Ala Ser Asp Val Lys Asn Glu Ala Asp Gly65 70 75 80Met Ile Phe Arg Ala Glu Lys Ala Val Lys Asp Tyr His Asp Lys Ile

85 90 95Pro Ala Glu Leu Val Lys Glu Ile Glu Glu His Ile Glu Lys Val Arg

100 105 110Gln Ala Ile Lys Glu Asp Ala Ser Thr Thr Ala Ile Lys Ala Ala Ser

115 120 125Asp Glu Leu Ser Thr Arg Met Gln Lys Ile Gly Glu Ala Met Gln Ala

130 135 140Gln Ser Ala Ser Ala Ala Ala Ser Ser Ala Ala Asn Ala Gln Gly Gly145 150 155 160Pro Asn Ile Asn Ser Glu Asp Leu Lys Lys His Ser Phe Ser Thr Arg

165 170 175Pro Pro Ala Gly Gly Ser Ala

180

<210>302

<211>232

<212>PRT

<213>衣原体属

<400>302Met Thr Lys His Gly Lys Arg Ile Arg Gly Ile Gln Glu Thr Tyr Asp

5 10 15Leu Ala Lys Ser Tyr Ser Leu Gly Glu Ala Ile Asp Ile Leu Lys Gln

20 25 30Cys Pro Thr Val Arg Phe Asp Gln Thr Val Asp Val Ser Val Lys Leu

35 40 45Gly Ile Asp Pro Arg Lys Ser Asp Gln Gln Ile Arg Gly Ser Val Ser

50 55 60Leu Pro His Gly Thr Gly Lys Val Leu Arg Ile Leu Val Phe Ala Ala65 70 75 80Gly Asp Lys Ala Ala Glu Ala Ile Glu Ala Gly Ala Asp Phe Val Gly

85 90 95Ser Asp Asp Leu Val Glu Lys Ile Lys Gly Gly Trp Val Asp Phe Asp

100 105 110Val Ala Val Ala Thr Pro Asp Met Met Arg Glu Val Gly Lys Leu Gly

115 120 125Lys Val Leu Gly Pro Arg Asn Leu Met Pro Thr Pro Lys Ala Gly Thr

130 135 140Val Thr Thr Asp Val Val Lys Thr Ile Ala Glu Leu Arg Lys Gly Lys145 150 155 160Ile Glu Phe Lys Ala Asp Arg Ala Gly Val Cys Asn Val Gly Val Ala

165 170 175Lys Leu Ser Phe Asp Ser Ala Gln Ile Lys Glu Asn Val Glu Ala Leu

180 185 190Cys Ala Ala Leu Val Lys Ala Lys Pro Ala Thr Ala Lys Gly Gln Tyr

195 200 205Leu Val Asn Phe Thr Ile Ser Ser Thr Met Gly Pro Gly Val Thr Val

210 215 220Asp Thr Arg Glu Leu Ile Ala Leu225 230<210>303<211>238<212>PRT<213>衣原体属<400>303Ile Asn Ser Lys Leu Glu Thr Lys Asn Leu Ile Tyr Leu Lys Leu Lys

5 10 15Ile Lys Lys Ser Phe Lys Met Gly Asn Ser Gly Phe Tyr Leu Tyr Asn

20 25 30Thr Gln Asn Cys Val Phe Ala Asp Asn Ile Lys Val Gly Gln Met Thr

35 40 45Glu Pro Leu Lys Asp Gln Gln Ile Ile Leu Gly Thr Thr Ser Thr Pro

50 55 60Val Ala Ala Lys Met Thr Ala Ser Asp Gly Ile Ser Leu Thr Val Ser65 70 75 80Asn Asn Pro Ser Thr Asn Ala Ser Ile Thr Ile Gly Leu Asp Ala Glu

85 90 95Lys Ala Tyr Gln Leu Ile Leu Glu Lys Leu Gly Asp Gln Ile Leu Gly

100 105 110Gly Ile Ala Asp Thr Ile Val Asp Ser Thr Val Gln Asp Ile Leu Asp

115 120 125Lys Ile Thr Thr Asp Pro Ser Leu Gly Leu Leu Lys Ala Phe Asn Asn

130 135 140Phe Pro Ile Thr Asn Lys Ile Gln Cys Asn Gly Leu Phe Thr Pro Arg145 150 155 160Asn Ile Glu Thr Leu Leu Gly Gly Thr Glu Ile Gly Lys Phe Thr Val

165 170 175Thr Pro Lys Ser Ser Gly Ser Met Phe Leu Val Ser Ala Asp Ile Ile

180 185 190Ala Ser Arg Met Glu Gly Gly Val Val Leu Ala Leu Val Arg Glu Gly

195 200 205Asp Ser Lys Pro Tyr Ala Ile Ser Tyr Gly Tyr Ser Ser Gly Val Pro

210 215 220Asn Leu Cys Ser Leu Arg Thr Arg Ile Ile Asn Thr Gly Leu225 230 235<210>304<211>133<212>PRT<213>衣原体属<400>304His Met His His His His His His Met Ala Ser Ile Cys Gly Arg Leu

5 10 15Gly Ser Gly Thr Gly Asn Ala Leu Lys Ala Phe Phe Thr Gln Pro Ser

20 25 30Asn Lys Met Ala Arg Val Val Asn Lys Thr Lys Gly Met Asp Lys Thr

35 40 45Val Lys Val Ala Lys Ser Ala Ala Glu Leu Thr Ala Asn Ile Leu Glu

50 55 60Gln Ala Gly Gly Ala Gly Ser Ser Ala His Ile Thr Ala Ser Gln Val65 70 75 80Ser Lys Gly Leu Gly Asp Thr Arg Thr Val Val Ala Leu Gly Asn Ala

85 90 95Phe Asn Gly Ala Leu Pro Gly Thr Val Gln Ser Ala Gln Ser Phe Phe

100 105 110Ser His Met Lys Ala Ala Ser Gln Lys Thr Gln Glu Gly Asp Glu Gly

115 120 125Leu Thr Ala Asp Leu

130<210>305<211>125<212>PRT<213>衣原体属<400>305Met Ala Ser Ile Cys Gly Arg Leu Gly Ser Gly Thr Gly Asn Ala Leu

5 10 15Lys Ala Phe Phe Thr Gln Pro Ser Asn Lys Met Ala Arg Val Val Asn

20 25 30Lys Thr Lys Gly Met Asp Lys Thr Val Lys Val Ala Lys Ser Ala Ala

35 40 45Glu Leu Thr Ala Asn Ile Leu Glu Gln Ala Gly Gly Ala Gly Ser Ser

85 90 95Val Gln Ser Ala Gln Ser Phe Phe Ser His Met Lys Ala Ala Ser Gln

100 105 110Lys Thr Gln Glu Gly Asp Glu Gly Leu Thr Ala Asp Leu

115 120 125<210>306<211>38<212>DNA<213>沙眼衣原体<400>306gagagcggcc gctcatgttt ataacaaagg aacttatg 38<210>307<211>39<212>DNA<213>沙眼衣原体<400>307gagagcggcc gcttacttag gtgagaagaa gggagtttc 39<210>308<211>1860<212>DNA<213>沙眼衣原体<400>308atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct catgtttata acaaaggaac ttatgaatcg agttatagaa 480atccatgctc actacgatca aagacaactt tctcaatctc caaatacaaa cttcttagta 540catcatcctt atcttactct tattcccaag tttctactag gagctctaat cgtctatgct 600ccttattcgt ttgcagaaat ggaattagct atttctggac ataaacaagg taaagatcga 660gataccttta ccatgatctc ttcctgtcct gaaggcacta attacatcat caatcgcaaa 720ctcatactca gtgatttctc gttactaaat aaagtttcat cagggggagc ctttcggaat 780ctagcaggga aaatttcctt cttaggaaaa aattcttctg cgtccattca ttttaaacac 840attaatatca atggttttgg agccggagtc ttttctgaat cctctattga atttactgat 900ttacgaaaac ttgttgcttt tggatctgaa agcacaggag gaatttttac tgcgaaagag 960gacatctctt ttaaaaacaa ccaccacatt gccttccgca ataatatcac caaagggaat 1020ggtggcgtta tccagctcca aggagatatg aaaggaagcg tatcctttgt agatcaacgt 1080ggagctatca tctttaccaa taaccaagct gtaacttctt catcaatgaa acatagtggt 1140cgtggaggag caattagcgg tgacttcgca ggatccagaa ttctttttct taataaccaa 1200caaattactt tcgaaggcaa tagcgctgtg catggaggtg ctatctacaa taagaatggc 1260cttgtcgagt tcttaggaaa tgcaggacct cttgccttta aagagaacac aacaatagct 1320aacgggggag ctatatacac aagtaatttc aaagcgaatc aacaaacatc ccccattcta 1380ttctctcaaa atcatgcgaa taagaaaggc ggagcgattt acgcgcaata tgtgaactta 1440gaacagaatc aagatactat tcgctttgaa aaaaataccg ctaaagaagg cggtggagcc 1500atcacctctt ctcaatgctc aattactgct cataatacca tcactttttc cgataatgct 1560gccggagatc ttggaggagg agcaattctt ctagaaggga aaaaaccttc tctaaccttg 1620attgctcata gtggtaatat tgcatttagc ggcaatacca tgcttcatat caccaaaaaa 1680gcttccctag atcgacacaa ttctatctta atcaaagaag ctccctataa aatccaactt 1740gcagcgaaca aaaaccattc tattcatttc tttgatcctg tcatggcatt gtcagcatca 1800tcttccccta tacaaatcaa tgctcctgag tatgaaactc ccttcttctc acctaagtaa 1860<210>309<211>619<212>PRT<213>沙眼衣原体<400>309Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Met Phe Ile Thr Lys Glu Leu Met Asn Arg Val Ile Glu145 150 155 160Ile His Ala His Tyr Asp Gln Arg Gln Leu Ser Gln Ser Pro Asn Thr

165 170 175Asn Phe Leu Val His His Pro Tyr Leu Thr Leu Ile Pro Lys Phe Leu

180 185 190Leu Gly Ala Leu Ile Val Tyr Ala Pro Tyr Ser Phe Ala Glu Met Glu

195 200 205Leu Ala Ile Ser Gly His Lys Gln Gly Lys Asp Arg Asp Thr Phe Thr

210 215 220Met Ile Ser Ser Cys Pro Glu Gly Thr Asn Tyr Ile Ile Asn Arg Lys225 230 235 240Leu Ile Leu Ser Asp Phe Ser Leu Leu Asn Lys Val Ser Ser Gly Gly

245 250 255Ala Phe Arg Asn Leu Ala Gly Lys Ile Ser Phe Leu Gly Lys Asn Ser

260 265 270Ser Ala Ser Ile His Phe Lys His Ile Asn Ile Asn Gly Phe Gly Ala

275 280 285Gly Val Phe Ser Glu Ser Ser Ile Glu Phe Thr Asp Leu Arg Lys Leu

290 295 300Val Ala Phe Gly Ser Glu Ser Thr Gly Gly Ile Phe Thr Ala Lys Glu305 310 315 320Asp Ile Ser Phe Lys Asn Asn His His Ile Ala Phe Arg Asn Asn Ile

325 330 335Thr Lys Gly Asn Gly Gly Val Ile Gln Leu Gln Gly Asp Met Lys Gly

340 345 350Ser Val Ser Phe Val Asp Gln Arg Gly Ala Ile Ile Phe Thr Asn Asn

355 360 365Gln Ala Val Thr Ser Ser Ser Met Lys His Ser Gly Arg Gly Gly Ala

370 375 380Ile Ser Gly Asp Phe Ala Gly Ser Arg Ile Leu Phe Leu Asn Asn Gln385 390 395 400Gln Ile Thr Phe Glu Gly Asn Ser Ala Val His Gly Gly Ala Ile Tyr

405 410 415Asn Lys Asn Gly Leu Val Glu Phe Leu Gly Asn Ala Gly Pro Leu Ala

420 425 430Phe Lys Glu Asn Thr Thr Ile Ala Asn Gly Gly Ala Ile Tyr Thr Ser

435 440 445Asn Phe Lys Ala Asn Gln Gln Thr Sar Pro Ile Leu Phe Ser Gln Asn

450 455 460His Ala Asn Lys Lys Gly Gly Ala Ile Tyr Ala Gln Tyr Val Asn Leu465 470 475 480Glu Gln Asn Gln Asp Thr Ile Arg Phe Glu Lys Asn Thr Ala Lys Glu

485 490 495Gly Gly Gly Ala Ile Thr Ser Ser Gln Cys Ser Ile Thr Ala His Asn

500 505 510Thr Ile Thr Phe Ser Asp Asn Ala Ala Gly Asp Leu Gly Gly Gly Ala

515 520 525Ile Leu Leu Glu Gly Lys Lys Pro Ser Leu Thr Leu Ile Ala His Ser

530 535 540Gly Asn Ile Ala Phe Ser Gly Asn Thr Met Leu His Ile Thr Lys Lys545 550 555 560Ala Ser Leu Asp Arg His Asn Ser Ile Leu Ile Lys Glu Ala Pro Tyr

565 570 575Lys Ile Gln Leu Ala Ala Asn Lys Asn His Ser Ile His Phe Phe Asp

580 585 590Pro Val Met Ala Leu Ser Ala Ser Ser Ser Pro Ile Gln Ile Asn Ala

595 600 605Pro Glu Tyr Glu Thr Pro Phe Phe Ser Pro Lys

610 615<210>310<211>39<212>DNA<213>沙眼衣原体<400>310gagagcggcc gctccattct attcatttct ttgatcctg 39<210>311<211>33<212>DNA<213>沙眼衣原体<400>311gagagcggcc gcttagaagc caacatagcc tcc 33<210>312<211>2076<212>DNA<213>沙眼衣原体<400>312atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct ccattctatt catttctttg atcctgtcat ggcattgtca 480gcatcatctt cccctataca aatcaatgct cctgagtatg aaactccctt cttctcacct 540aagggtatga tcgttttctc gggtgcgaat cttttagatg atgctaggga agatgttgca 600aatagaacat cgatttttaa ccaacccgtt catctatata atggcaccct atctatcgaa 660aatggagccc atctgattgt ccaaagcttc aaacagaccg gaggacgtat cagtttatct 720ccaggatcct ccttggctct atacacgatg aactcgttct tccatggcaa catatccagc 780aaagaacccc tagaaattaa tggtttaagc tttggagtag atatctctcc ttctaatctt 840caagcagaga tccgtgccgg caacgctcct ttacgattat ccggatcccc atctatccat 900gatcctgaag gattattcta cgaaaatcgc gatactgcag catcaccata ccaaatggaa 960atcttgctca cctctgataa aactgtagat atctccaaat ttactactga ttctctagtt 1020acgaacaaac aatcaggatt ccaaggagcc tggcatttta gctggcagcc aaatactata 1080aacaatacta aacaaaaaat attaagagct tcttggctcc caacaggaga atatgtcctt 1140gaatccaatc gagtggggcg tgccgttcct aattccttat ggagcacatt tttactttta 1200cagacagcct ctcataactt aggcgatcat ctatgtaata atcgatctct tattcctact 1260tcatacttcg gagttttaat tggaggaact ggagcagaaa tgtctaccca ctcctcagaa 1320gaagaaagct ttatatctcg tttaggagct acaggaacct ctatcatacg cttaactccc 1380tccctgacac tctctggagg aggctcacat atgttcggag attcgttcgt tgcagactta 1440ccagaacaca tcacttcaga aggaattgtt cagaatgtcg gtttaaccca tgtctgggga 1500ccccttactg tcaattctac attatgtgca gccttagatc acaacgcgat ggtccgcata 1560tgctccaaaa aagatcacac ctatgggaaa tgggatacat tcggtatgcg aggaacatta 1620ggagcctctt atacattcct agaatatgat caaactatgc gcgtattctc attcgccaac 1680atcgaagcca caaatatctt gcaaagagct tttactgaaa caggctataa cccaagaagt 1740ttttccaaga caaaacttct aaacatcgcc atccccatag ggattggtta tgaattctgc 1800ttagggaata gctcttttgc tctactaggt aagggatcca tcggttactc tcgagatatt 1860aaacgagaaa acccatccac tcttgctcac ctggctatga atgattttgc ttggactacc 1920aatggctgtt cagttccaac ctccgcacac acattggcaa atcaattgat tcttcgctat 1980aaagcatgtt ccttatacat cacggcatat actatcaacc gtgaagggaa gaacctctcc 2040aatagcttat cctgcggagg ctatgttggc ttctaa 2076<210>313<211>691<212>PRT<213>沙眼衣原体<400>313Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu AsT Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu His Ser Ile His Phe Phe Asp Pro Val Met Ala Leu Ser145 150 155 160Ala Ser Ser Ser Pro Ile Gln Ile Asn Ala Pro Glu Tyr Glu Thr Pro

165 170 175Phe Phe Ser Pro Lys Gly Met Ile Val Phe Ser Gly Ala Asn Leu Leu

180 185 190Asp Asp Ala Arg Glu Asp Val Ala Asn Arg Thr Ser Ile Phe Asn Gln

195 200 205Pro Val His Leu Tyr Asn Gly Thr Leu Ser Ile Glu Asn Gly Ala His

210 215 220Leu Ile Val Gln Ser Phe Lys Gln Thr Gly Gly Arg Ile Ser Leu Ser225 230 235 240Pro Gly Ser Ser Leu Ala Leu Tyr Thr Met Asn Ser Phe Phe His Gly

245 250 255Asn Ile Ser Ser Lys Glu Pro Leu Glu Ile Asn Gly Leu Ser Phe Gly

260 265 270Val Asp Ile Ser Pro Ser Asn Leu Gln Ala Glu Ile Arg Ala Gly Asn

275 280 285Ala Pro Leu Arg Leu Ser Gly Ser Pro Ser Ile His Asp Pro Glu Gly

290 295 300Leu Phe Tyr Glu Asn Arg Asp Thr Ala Ala Ser Pro Tyr Gln Met Glu305 310 315 320Ile Leu Leu Thr Ser Asp Lys Thr Val Asp Ile Ser Lys Phe Thr Thr

325 330 335Asp Ser Leu Val Thr Asn Lys Gln Ser Gly Phe Gln Gly Ala Trp His

340 345 350Phe Ser Trp Gln Pro Asn Thr Ile Asn Asn Thr Lys Gln Lys Ile Leu

355 360 365Arg Ala Ser Trp Leu Pro Thr Gly Glu Tyr Val Leu Glu Ser Asn Arg

370 375 380Val Gly Arg Ala Val Pro Asn Ser Leu Trp Ser Thr Phe Leu Leu Leu385 390 395 400Gln Thr Ala Ser His Asn Leu Gly Asp His Leu Cys Asn Asn Arg Ser

405 410 415Leu Ile Pro Thr Ser Tyr Phe Gly Val Leu Ile Gly Gly Thr Gly Ala

420 425 430Glu Met Ser Thr His Ser Ser Glu Glu Glu Ser Phe Ile Ser Arg Leu

435 440 445Gly Ala Thr Gly Thr Ser Ile Ile Arg Leu Thr Pro Ser Leu Thr Leu

450 455 460Ser Gly Gly Gly Ser His Met Phe Gly Asp Ser Phe Val Ala Asp Leu465 470 475 480Pro Glu His Ile Thr Ser Glu Gly Ile Val Gln Asn Val Gly Leu Thr

485 490 495His Val Trp Gly Pro Leu Thr Val Asn Ser Thr Leu Cys Ala Ala Leu

500 505 510Asp His Asn Ala Met Val Arg Ile Cys Ser Lys Lys Asp His Thr Tyr

515 520 525Gly Lys Trp Asp Thr Phe Gly Met Arg Gly Thr Leu Gly Ala Ser Tyr

530 535 540Thr Phe Leu Glu Tyr Asp Gln Thr Met Arg Val Phe Ser Phe Ala Asn545 550 555 560Ile Glu Ala Thr Asn Ile Leu Gln Arg Ala Phe Thr Glu Thr Gly Tyr

565 570 575Asn Pro Arg Ser Phe Ser Lys Thr Lys Leu Leu Asn Ile Ala Ile Pro

580 585 590Ile Gly Ile Gly Tyr Glu Phe Cys Leu Gly Asn Ser Ser Phe Ala Leu

595 600 605Leu Gly Lys Gly Ser Ile Gly Tyr Ser Arg Asp Ile Lys Arg Glu Asn

610 615 620Pro Ser Thr Leu Ala His Leu Ala Met Asn Asp Phe Ala Trp Thr Thr625 630 635 640Asn Gly Cys Ser Val Pro Thr Ser Ala His Thr Leu Ala Asn Gln Leu

645 650 655Ile Leu Arg Tyr Lys Ala Cys Ser Leu Tyr Ile Thr Ala Tyr Thr Ile

660 665 670Asn Arg Glu Gly Lys Asn Leu Ser Asn Ser Leu Ser Cys Gly Gly Tyr

675 680 685Val Gly Phe

690<210>314<211>38<212>DNA<213>沙眼衣原体<400>314gagagcggcc gctcatgatt aaaagaactt ctctatcc 38<210>315<211>36<212>DNA<213>沙眼衣原体<400>315agcggccgct tataattctg catcatcttc tatggc 36<210>316<211>1941<212>DNA<213>沙眼衣原体<400>316atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct catgattaaa agaacttctc tatcctttgc ttgcctcagt 480tttttttatc tttcaactat atccattttg caagctaatg aaacggatac gctacagttc 540cggcgattta ctttttcgga tagagagatt cagttcgtcc tagatcccgc ctctttaatt 600accgcccaaa acatcgtttt atctaattta cagtcaaacg gaaccggagc ctgtaccatt 660tcaggcaata cgcaaactca aatcttttct aattccgtta acaccaccgc agattctggt 720ggagcctttg atatggttac tacctcattc acggcctctg ataatgctaa tctactcttc 780tgcaacaact actgcacaca taataaaggc ggaggagcta ttcgttccgg aggacctatt 840cgattcttaa ataatcaaga cgtgcttttt tataataaca tatcggcagg ggctaaatat 900gttggaacag gagatcacaa cgaaaaaaat aggggcggtg cgctttatgc aactactatc 960actttgacag ggaatcgaac tcttgccttt attaacaata tgtctggaga ctgcggtgga 1020gccatctctg ctgacactca aatatcaata actgataccg ttaaaggaat tttatttgaa 1080aacaatcaca cgctcaatca tataccgtac acgcaagctg aaaatatggc acgaggagga 1140gcaatctgta gtagaagaga cttgtgctca atcagcaata attctggtcc catagttttt 1200aactataacc aaggcgggaa aggtggagct attagcgcta cccgatgtgt tattgacaat 1260aacaaagaaa gaatcatctt ttcaaacaat agttccctgg gatggagcca atcttcttct 1320gcaagtaacg gaggagccat tcaaacgaca caaggattta ctttacgaaa taataaaggc 1380tctatctact tcgacagcaa cactgctaca cacgccgggg gagccttaa ctgtggttac 1440attgacatcc gagataacgg acccgtctat tttctaaata actctgctgc ctggggagcg 1500gcctttaatt tatcgaaacc acgttcagcg acaaattata tccatacagg gacaggcgat 1560attgttttta ataataacgt tgtctttact cttgacggta atttattagg gaaacggaaa 1620ctttttcata ttaataataa tgagataaca ccatatacat tgtctctcgg cgctaaaaaa 1680gatactcgta tctattttta tgatcttttc caatgggagc gtgttaaaga aaatactagc 1740aataacccac catctcctac cagtagaaac accattaccg ttaacccgga aacagagttt 1800tctggagctg ttgtgttctc ctacaatcaa atgtctagtg acatacgaac tctgatgggt 1860aaagaacaca attacattaa agaagcccca actactttaa aattcggaac gctagccata 1920gaagatgatg cagaattata a 1941<210>317<211>646<212>PRT<213>沙眼衣原体<400>317Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Met Ile Lys Arg Thr Ser Leu Ser Phe Ala Cys Leu Ser145 150 155 160Phe Phe Tyr Leu Ser Thr Ile Ser Ile Leu Gln Ala Asn Glu Thr Asp

165 170 175Thr Leu Gln Phe Arg Arg Phe Thr Phe Ser Asp Arg Glu Ile Gln Phe

180 185 190Val Leu Asp Pro Ala Ser Leu Ile Thr Ala Gln Asn Ile Val Leu Ser

195 200 205Asn Leu Gln Ser Asn Gly Thr Gly Ala Cys Thr Ile Ser Gly Asn Thr

210 215 220Gln Thr Gln Ile Phe Ser Asn Ser Val Asn Thr Thr Ala Asp Ser Gly225 230 235 240Gly Ala Phe Asp Met Val Thr Thr Ser Phe Thr Ala Ser Asp Asn Ala

245 250 255Asn Leu Leu Phe Cys Asn Asn Tyr Cys Thr His Asn Lys Gly Gly Gly

260 265 270Ala Ile Arg Ser Gly Gly Pro Ile Arg Phe Leu Asn Asn Gln Asp Val

275 280 285Leu Phe Tyr Asn Asn Ile Ser Ala Gly Ala Lys Tyr Val Gly Thr Gly

290 295 300Asp His Asn Glu Lys Asn Arg Gly Gly Ala Leu Tyr Ala Thr Thr Ile305 310 315 320Thr Leu Thr Gly Asn Arg Thr Leu Ala Phe Ile Asn Asn Met Ser Gly

325 330 335Asp Cys Gly Gly Ala Ile Ser Ala Asp Thr Gln Ile Ser Ile Thr Asp

340 345 350Thr Val Lys Gly Ile Leu Phe Glu Asn Asn His Thr Leu Asn His Ile

355 360 365Pro Tyr Thr Gln Ala Glu Asn Met Ala Arg Gly Gly Ala Ile Cys Ser

370 375 380Arg Arg Asp Leu Cys Ser Ile Ser Asn Asn Ser Gly Pro Ile Val Phe385 390 395 400Asn Tyr Asn Gln Gly Gly Lys Gly Gly Ala Ile Ser Ala Thr Arg Cys

405 410 415Val Ile Asp Asn Asn Lys Glu Arg Ile Ile Phe Ser Asn Asn Ser Ser

420 425 430Leu Gly Trp Ser Gln Ser Ser Ser Ala Ser Asn Gly Gly Ala Ile Gln

435 440 445Thr Thr Gln Gly Phe Thr Leu Arg Asn Asn Lys Gly Ser Ile Tyr Phe

450 455 460Asp Ser Asn Thr Ala Thr His Ala Gly Gly Ala Ile Asn Cys Gly Tyr465 470 475 480Ile Asp Ile Arg Asp Asn Gly Pro Val Tyr Phe Leu Asn Asn Ser Ala

485 490 495Ala Trp Gly Ala Ala Phe Asn Leu Ser Lys Pro Arg Ser Ala Thr Asn

500 505 510Tyr Ile His Thr Gly Thr Gly Asp Ile Val Phe Asn Asn Asn Val Val

515 520 525Phe Thr Leu Asp Gly Asn Leu Leu Gly Lys Arg Lys Leu Phe His Ile

530 535 540Asn Asn Asn Glu Ile Thr Pro Tyr Thr Leu Ser Leu Gly Ala Lys Lys545 550 555 560Asp Thr Arg Ile Tyr Phe Tyr Asp Leu Phe Gln Trp Glu Arg Val Lys

565 570 575Glu Asn Thr Ser Asn Asn Pro Pro Ser Pro Thr Ser Arg Asn Thr Ile

580 585 590Thr Val Asn Pro Glu Thr Glu Phe Ser Gly Ala Val Val Phe Ser Tyr

595 600 605Asn Gln Met Ser Ser Asp Ile Arg Thr Leu Met Gly Lys Glu His Asn

610 615 620Tyr Ile Lys Glu Ala Pro Thr Thr Leu Lys Phe Gly Thr Leu Ala Ile625 630 635 640Glu Asp Asp Ala Glu Leu

645<210>318<211>34<212>DNA<213>沙眼衣原体<400>318gagagcggcc gctcgacata cgaactctga tggg 34<210>319<211>33<212>DNA<213>沙眼衣原体<400>319gagagcggcc gcttaaaaga ccagagctcc tcc 33<210>320<211>2148<212>DNA<213>沙眼衣原体<400>320atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cgacatacga actctgatgg gtaaagaaca caattacatt 480aaagaagccc caactacttt aaaattcgga acgctagcca tagaagatga tgcagaatta 540gaaatcttca atatcccgtt tacccaaaat ccgactagcc ttcttgcttt aggaagcggc 600gctacgctga ctgttggaaa gcacggtaag ctcaatatta caaatcttgg tgttatttta 660cccattattc tcaaagaggg gaagagtccg ccttgtattc gcgtcaaccc acaagatatg 720acccaaaata ctggtaccgg ccaaactcca tcaagcacaa gtagtataag cactccaatg 780attatcttta atgggcgcct ctcaattgta gacgaaaatt atgaatcagt ctacgacagt 840atggacctct ccagagggaa agcagaacaa ctaattctat ccatagaaac cactaatgat 900gggcaattag actccaattg gcaaagttct ctgaatactt ctctactctc tcctccacac 960tatggctatc aaggtctatg gactcctaat tggataacaa caacctatac catcacgctt 1020aataataatt cttcagctcc aacatctgct acctccatcg ctgagcagaa aaaaactagt 1080gaaactttta ctcctagtaa cacaactaca gctagtatcc ctaatattaa agcttccgca 1140ggatcaggct ctggatcggc ttccaattca ggagaagtta cgattaccaa acataccctt 1200gttgtaaact gggcaccagt cggctacata gtagatccta ttcgtagagg agatctgata 1260gccaatagct tagtacattc aggaagaaac atgaccatgg gcttacgatc attactcccg 1320gataactctt ggtttgcttt gcaaggagct gcaacaacat tatttacaaa acaacaaaaa 1380cgtttgagtt atcatggcta ctcttctgca tcaaaggggt ataccgtctc ttctcaagca 1440tcaggagctc atggtcataa gtttcttctt tccttctccc agtcatctga taagatgaaa 1500gaaaaagaaa caaataaccg cctttcttct cgttactatc tttctgcttt atgtttcgaa 1560catcctatgt ttgatcgcat tgctcttatc ggagcagcag cttgcaatta tggaacacat 1620aacatgcgga gtttctatgg aactaaaaaa tcttctaaag ggaaatttca ctctacaacc 1680ttaggagctt ctcttcgctg tgaactacgc gatagtatgc ctttacgatc aataatgctc 1740accccatttg ctcaggcttt attctctcga acagaaccag cttctatccg agaaagcggt 1800gatctagcta gattatttac attagagcaa gcccatactg ccgttgtctc tccaatagga 1860atcaaaggag cttattcttc tgatacatgg ccaacactct cttgggaaat ggaactagct 1920taccaaccca ccctctactg gaaacgtcct ctactcaaca cactattaat ccaaaataac 1980ggttcttggg tcaccacaaa taccccatta gctaaacatt ccttttatgg gagaggttct 2040cactccctca aattttctca tctgaaacta tttgctaact atcaagcaga agtggctact 2100tccactgtct cacactacat caatgcagga ggagctctgg tcttttaa 2148<210>321<211>715<212>PRT<213>沙眼衣原体<400>321Met His His His His His His Thr A1a Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Asp Ile Arg Thr Leu Met Gly Lys Glu His Asn Tyr Ile145 150 155 160Lys Glu Ala Pro Thr Thr Leu Lys Phe Gly Thr Leu Ala Ile Glu Asp

165 170 175Asp Ala Glu Leu Glu Ile Phe Asn Ile Pro Phe Thr Gln Asn Pro Thr

180 185 190Ser Leu Leu Ala Leu Gly Ser Gly Ala Thr Leu Thr Val Gly Lys His

195 200 205Gly Lys Leu Asn Ile Thr Asn Leu Gly Val Ile Leu Pro Ile Ile Leu

210 215 220Lys Glu Gly Lys Ser Pro Pro Cys Ile Arg Val Asn Pro Gln Asp Met225 230 235 240Thr Gln Asn Thr Gly Thr Gly Gln Thr Pro Ser Ser Thr Ser Ser Ile

245 250 255Ser Thr Pro Met Ile Ile Phe Asn Gly Arg Leu Ser Ile Val Asp Glu

260 265 270Asn Tyr Glu Ser Val Tyr Asp Ser Met Asp Leu Ser Arg Gly Lys Ala

275 280 285Glu Gln Leu Ile Leu Ser Ile Glu Thr Thr Asn Asp Gly Gln Leu Asp

290 295 300Ser Asn Trp Gln Ser Ser Leu Asn Thr Ser Leu Leu Ser Pro Pro His305 310 315 320Tyr Gly Tyr Gln Gly Leu Trp Thr Pro Asn Trp Ile Thr Thr Thr Tyr

325 330 335Thr Ile Thr Leu Asn Asn Asn Ser Ser Ala Pro Thr Ser Ala Thr Ser

340 345 350Ile Ala Glu Gln Lys Lys Thr Ser Glu Thr Phe Thr Pro Ser Asn Thr

355 360 365Thr Thr Ala Ser Ile Pro Asn Ile Lys Ala Ser Ala Gly Ser Gly Ser

370 375 380Gly Ser Ala Ser Asn Ser Gly Glu Val Thr Ile Thr Lys His Thr Leu385 390 395 400Val Val Asn Trp Ala Pro Val Gly Tyr Ile Val Asp Pro Ile Arg Arg

405 410 415Gly Asp Leu Ile Ala Asn Ser Leu Val His Ser Gly Arg Asn Met Thr

420 425 430Met Gly Leu Arg Ser Leu Leu Pro Asp Asn Ser Trp Phe Ala Leu Gln

435 440 445Gly Ala Ala Thr Thr Leu Phe Thr Lys Gln Gln Lys Arg Leu Ser Tyr

450 455 460His Gly Tyr Ser Ser Ala Ser Lys Gly Tyr Thr Val Ser Ser Gln Ala465 470 475 480Ser Gly Ala His Gly His Lys Phe Leu Leu Ser Phe Ser Gln Ser Ser

485 490 495Asp Lys Met Lys Glu Lys Glu Thr Asn Asn Arg Leu Ser Ser Arg Tyr

500 505 510Tyr Leu Ser Ala Leu Cys Phe Glu His Pro Met Phe Asp Arg Ile Ala

515 520 525Leu Ile Gly Ala Ala Ala Cys Asn Tyr Gly Thr His Asn Met Arg Ser

530 535 540Phe Tyr Gly Thr Lys Lys Ser Ser Lys Gly Lys Phe His Ser Thr Thr545 550 555 560Leu Gly Ala Ser Leu Arg Cys Glu Leu Arg Asp Ser Met Pro Leu Arg

565 570 575Ser Ile Met Leu Thr Pro Phe Ala Gln Ala Leu Phe Ser Arg Thr Glu

580 585 590Pro Ala Ser Ile Arg Glu Ser Gly Asp Leu Ala Arg Leu Phe Thr Leu

595 600 605Glu Gln Ala His Thr Ala Val Val Ser Pro Ile Gly Ile Lys Gly Ala

610 615 620Tyr Ser Ser Asp Thr Trp Pro Thr Leu Ser Trp Glu Met Glu Leu Ala625 630 635 640Tyr Gln Pro Thr Leu Tyr Trp Lys Arg Pro Leu Leu Asn Thr Leu Leu

645 650 655Ile Gln Asn Asn Gly Ser Trp Val Thr Thr Asn Thr Pro Leu Ala Lys

660 665 670His Ser Phe Tyr Gly Arg Gly Ser His Ser Leu Lys Phe Ser His Leu

675 680 685Lys Leu Phe Ala Asn Tyr Gln Ala Glu Val Ala Thr Ser Thr Val Ser

690 695 700His Tyr Ile Asn Ala Gly Gly Ala Leu Val Phe705 7l0 7l5<210>322<211>37<212>DNA<213>沙眼衣原体<400>322gagagcggcc gctcatgcct ttttctttga gatctac 37<210>323<211>36<212>DNA<213>沙眼衣原体<400>323gagagcggcc gcttacacag atccattacc ggactg 36<210>324<21l>1896<212>DNA<213>沙眼衣原体<400>324atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct catgcctttt tctttgagat ctacatcatt ttgtttttta 480gcttgtttgt gttcctattc gtatggattc gcgagctctc ctcaagtgtt aacacctaat 540gtaaccactc cttttaaggg ggacgatgtt tacttgaatg gagactgcgc ttttgtcaat 600gtctatgcag gggcagagaa cggctcaatt atctcagcta atggcgacaa tttaacgatt 660accggacaaa accatacatt atcatttaca gattctcaag ggccagttct tcaaaattat 720gccttcattt cagcaggaga gacacttact ctgaaagatt tttcgagttt gatgttctcg 780aaaaatgttt cttgcggaga aaagggaatg atctcaggga aaaccgtgag tatttccgga 840gcaggcgaag tgattttttg ggataactct gtggggtatt ctcctttgtc tattgtgcca 900gcatcgactc caactcctcc agcaccagca ccagctcctg ctgcttcaag ctctttatct 960ccaacagtta gtgatgctcg gaaagggtct attttttctg tagagactag tttggagatc 1020tcaggcgtca aaaaaggggt catgttcgat aataatgccg ggaattttgg aacagttttt 1080cgaggtaata gtaataataa tgctggtagt gggggtagtg ggtctgctac aacaccaagt 1140tttacagtta aaaactgtaa agggaaagtt tctttcacag ataacgtagc ctcctgtgga 1200ggcggagtag tctacaaagg aactgtgctt ttcaaagaca atgaaggagg catattcttc 1260cgagggaaca cagcatacga tgatttaggg attcttgctg ctactagtcg ggatcagaat 1320acggagacag gaggcggtgg aggagttatt tgctctccag atgattctgt aaagtttgaa 1380ggcaataaag gttctattgt ttttgattac aactttgcaa aaggcagagg cggaagcatc 1440ctaacgaaag aattctctct tgtagcagat gattcggttg tctttagtaa caatacagca 1500gaaaaaggcg gtggagctat ttatgctcct actatcgata taagcacgaa tggaggatcg 1560attctgtttg aaagaaaccg agctgcagaa ggaggcgcca tctgcgtgag tgaagcaagc 1620tctggttcaa ctggaaatct tactttaagc gcttctgatg gggatattgt tttttctggg 1680aatatgacga gtgatcgtcc tggagagcgc agcgcagcaa gaatcttaag tgatggaacg 1740actgtttctt taaatgcttc cggactatcg aagctgatct tttatgatcc tgtagtacaa 1800aataattcag cagcgggtgc atcgacacca tcaccatctt cttcttctat gcctggtgct 1860gtcacgatta atcagtccgg taatggatct gtgtaa 1896<210>325<211>631<212>PRT<213>沙眼衣原体<400>325Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Met Pro Phe Ser Leu Arg Ser Thr Ser Phe Cys Phe Leu145 150 155 160Ala Cys Leu Cys Ser Tyr Ser Tyr Gly Phe Ala Ser Ser Pro Gln Val

165 170 175Leu Thr Pro Asn Val Thr Thr Pro Phe Lys Gly Asp Asp Val Tyr Leu

180 185 190Asn Gly Asp Cys Ala Phe Val Asn Val Tyr Ala Gly Ala Glu Asn Gly

195 200 205Ser Ile Ile Ser Ala Asn Gly Asp Asn Leu Thr Ile Thr Gly Gln Asn

210 215 220His Thr Leu Ser Phe Thr Asp Ser Gln Gly Pro Val Leu Gln Asn Tyr225 230 235 240Ala Phe Ile Ser Ala Gly Glu Thr Leu Thr Leu Lys Asp Phe Ser Ser

245 250 255Leu Met Phe Ser Lys Asn Val Ser Cys Gly Glu Lys Gly Met Ile Ser

260 265 270Gly Lys Thr Val Ser Ile Ser Gly Ala Gly Glu Val Ile Phe Trp Asp

275 280 285Asn Ser Val Gly Tyr Ser Pro Leu Ser Ile Val Pro Ala Ser Thr Pro

290 295 300Thr Pro Pro Ala Pro Ala Pro Ala Pro Ala Ala Ser Ser Ser Leu Ser305 310 315 320Pro Thr Val Ser Asp Ala Arg Lys Gly Ser Ile Phe Ser Val Glu Thr

325 330 335Ser Leu Glu Ile Ser Gly Val Lys Lys Gly Val Met Phe Asp Asn Asn

340 345 350Ala Gly Asn Phe Gly Thr Val Phe Arg Gly Asn Ser Asn Asn Asn Ala

355 360 365Gly Ser Gly Gly Ser Gly Ser Ala Thr Thr Pro Ser Phe Thr Val Lys

370 375 380Asn Cys Lys Gly Lys Val Ser Phe Thr Asp Asn Val Ala Ser Cys Gly385 390 395 400Gly Gly Val Val Tyr Lys Gly Thr Val Leu Phe Lys Asp Asn Glu Gly

405 410 415Gly Ile Phe Phe Arg Gly Asn Thr Ala Tyr Asp Asp Leu Gly Ile Leu

420 425 430Ala Ala Thr Ser Arg Asp Gln Asn Thr Glu Thr Gly Gly Gly Gly Gly

435 440 445Val Ile Cys Ser Pro Asp Asp Ser Val Lys Phe Glu Gly Asn Lys Gly

450 455 460Ser Ile Val Phe Asp Tyr Asn Phe Ala Lys Gly Arg Gly Gly Ser Ile465 470 475 480Leu Thr Lys Glu Phe Ser Leu Val Ala Asp Asp Ser Val Val Phe Ser

485 490 495Asn Asn Thr Ala Glu Lys Gly Gly Gly Ala Ile Tyr Ala Pro Thr Ile

500 505 510Asp Ile Ser Thr Asn Gly Gly Ser Ile Leu Phe Glu Arg Asn Arg Ala

515 520 525Ala Glu Gly Gly Ala Ile Cys Val Ser Glu Ala Ser Ser Gly Ser Thr

530 535 540Gly Asn Leu Thr Leu Ser Ala Ser Asp Gly Asp Ile Val Phe Ser Gly545 550 555 560Asn Met Thr Ser Asp Arg Pro Gly Glu Arg Ser Ala Ala Arg Ile Leu

565 570 575Ser Asp Gly Thr Thr Val Ser Leu Asn Ala Ser Gly Leu Ser Lys Leu

580 585 590Ile Phe Tyr Asp Pro Val Val Gln Asn Asn Ser Ala Ala Gly Ala Ser

595 600 605Thr Pro Ser Pro Ser Ser Ser Ser Met Pro Gly Ala Val Thr Ile Asn

610 615 620Gln Ser Gly Asn Gly Ser Val625 630<210>326<211>40<212>DNA<213>沙眼衣原体<400>326gagagcggcc gctcgatcct gtagtacaaa ataattcagc 40<210>327<211>33<212>DNA<213>沙眼衣原体<400>327gagagcggcc gcttaaaaga ttctattcaa gcc 33<210>328<211>2148<212>DNA<213>沙眼衣原体<400>328atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cgatcctgta gtacaaaata attcagcagc gggtgcatcg 480acaccatcac catcttcttc ttctatgcct ggtgctgtca cgattaatca gtccggtaat 540ggatctgtga tttttaccgc cgagtcattg actccttcag aaaaacttca agttcttaac 600tctacttcta acttcccagg agctctgact gtgtcaggag gggagttggt tgtgacggaa 660ggagctacct taactactgg gaccattaca gccacctctg gacgagtgac tttaggatcc 720ggagcttcgt tgtctgccgt tgcaggtgct gcaaataata attatacttg tacagtatct 780aagttgggga ttgatttaga atccttttta actcctaact ataagacggc catactgggt 840gcggatggaa cagttactgt taacagcggc tctactttag acctagtgat ggagaatgag 900gcagaggtct atgataatcc gctttttgtg ggatcgctga caattccttt tgttactcta 960tcttctagta gtgctagtaa cggagttaca aaaaattctg tcactattaa tgatgcagac 1020gctgcgcact atgggtatca aggctcttgg tctgcagatt ggacgaaacc gcctctggct 1080cctgatgcta aggggatggt acctcctaat accaataaca ctctgtatct gacatggaga 1140cctgcttcga attacggtga atatcgactg gatcctcaga gaaagggaga actagtaccc 1200aactctcttt gggtagcggg atctgcatta agaaccttta ctaatggttt gaaagaacac 1260tatgtttcta gagatgttgg atttgtagca tctctgcatg ctctcgggga ttatattctg 1320aattatacgc aagatgatcg ggatggcttt ttagctagat atgggggatt ccaggcgacc 1380gcagcctccc attatgaaaa tgggtcaata tttggagtgg cttttggaca actctatggt 1440cagacaaaga gcagaatgta ttactctaaa gatgctggga acatgacgat gttgtcctgt 1500ttcggaagaa gttacgtaga tattaaagga acagaaactg ttatgtattg ggagacggct 1560tatggctatt ctgtgcacag aatgcatacg cagtatttta atgacaaaac gcagaagttc 1620gatcattcga aatgtcattg gcacaacaat aactattatg cgtttgtagg tgccgagcat 1680aatttcttag agtactgcat tcctactcgt cagttagcta gagattatga gcttacaggg 1740tttatgcgtt ttgaaatggc cggaggatgg tccagttcta cacgagaaac tggctcccta 1800actagatatt tcgctcgcgg gtcagggcat aatatgtcgc ttccaatagg aattgtagct 1860catgcagttt ctcatgtgcg aagatctcct ccttctaaac tgacactaaa tatgggatat 1920agaccagaca tttggcgtgt cactccacat tgcaatatgg aaattattgc taacggagtg 1980aagacaccta tacaaggatc cccgctggca cggcatgcct tcttcttaga agtgcatgat 2040actttgtata ttcatcattt tggaagagcc tatatgaact attcattaga tgctcgtcgt 2100cgacaaaccg cacattttgt atctatgggc ttgaatagaa tcttttaa 2148<210>329<211>715<212>PRT<213>沙眼衣原体<400>329Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Asp Pro Val Val Gln Asn Asn Ser Ala Ala Gly Ala Ser145 150 155 160Thr Pro Ser Pro Ser Ser Ser Ser Met Pro Gly Ala Val Thr Ile Asn

165 170 175Gln Ser Gly Asn Gly Ser Val Ile Phe Thr Ala Glu Ser Leu Thr Pro

180 185 190Ser Glu Lys Leu Gln Val Leu Asn Ser Thr Ser Asn Phe Pro Gly Ala

195 200 205Leu Thr Val Ser Gly Gly Glu Leu Val Val Thr Glu Gly Ala Thr Leu

210 215 220Thr Thr Gly Thr Ile Thr Ala Thr Ser Gly Arg Val Thr Leu Gly Ser225 230 235 240Gly Ala Ser Leu Ser Ala Val Ala Gly Ala Ala Asn Asn Asn Tyr Thr

245 250 255Cys Thr Val Ser Lys Leu Gly Ile Asp Leu Glu Ser Phe Leu Thr Pro

260 265 270Asn Tyr Lys Thr Ala Ile Leu Gly Ala Asp Gly Thr Val Thr Val Asn

275 280 285Ser Gly Ser Thr Leu Asp Leu Val Met Glu Asn Glu Ala Glu Val Tyr

290 295 300Asp Asn Pro Leu Phe Val Gly Ser Leu Thr Ile Pro Phe Val Thr Leu305 310 315 320Ser Ser Ser Ser Ala Ser Asn Gly Val Thr Lys Asn Ser Val Thr Ile

325 330 335Asn Asp Ala Asp Ala Ala His Tyr Gly Tyr Gln Gly Ser Trp Ser Ala

340 345 350Asp Trp Thr Lys Pro Pro Leu Ala Pro Asp Ala Lys Gly Met Val Pro

355 360 365Pro Asn Thr Asr Asn Thr Leu Tyr Leu Thr Trp Arg Pro Ala Ser Asn

370 375 380Tyr Gly Glu Tyr Arg Leu Asp Pro Gln Arg Lys Gly Glu Leu Val Pro385 390 395 400Asn Ser Leu Trp Val Ala Gly Ser Ala Leu Arg Thr Phe Thr Asn Gly

405 410 415Leu Lys Glu His Tyr Val Ser Arg Asp Val Gly Phe Val Ala Ser Leu

420 425 430His Ala Leu Gly Asp Tyr Ile Leu Asn Tyr Thr Gln Asp Asp Arg Asp

435 440 445Gly Phe Leu Ala Arg Tyr Gly Gly Phe Gln Ala Thr Ala Ala Ser His

450 455 460Tyr Glu Asn Gly Ser Ile Phe Gly Val Ala Phe Gly Gln Leu Tyr Gly465 470 475 480Gln Thr Lys Ser Arg Met Tyr Tyr Ser Lys Asp Ala Gly Asn Met Thr

485 490 495Met Leu Ser Cys Phe Gly Arg Ser Tyr Val Asp Ile Lys Gly Thr Glu

500 505 510Thr Val Met Tyr Trp Glu Thr Ala Tyr Gly Tyr Ser Val His Arg Met

515 520 525His Thr Gln Tyr Phe Asn Asp Lys Thr Gln Lys Phe Asp His Ser Lys

530 535 540Cys His Trp His Asn Asn Asn Tyr Tyr Ala Phe Val Gly Ala Glu His545 550 555 560Asn Phe Leu Glu Tyr Cys Ile Pro Thr Arg Gln Leu Ala Arg Asp Tyr

565 570 575Glu Leu Thr Gly Phe Met Arg Phe Glu Met Ala Gly Gly Trp Ser Ser

580 585 590Ser Thr Arg Glu Thr Gly Ser Leu Thr Arg Tyr Phe Ala Arg Gly Ser

595 600 605Gly His Asn Met Ser Leu Pro Ile Gly Ile Val Ala His Ala Val Ser

610 615 620His Val Arg Arg Ser Pro Pro Ser Lys Leu Thr Leu Asn Met Gly Tyr625 630 635 640Arg Pro Asp Ile Trp Arg Val Thr Pro His Cys Asn Met Glu Ile Ile

645 650 655Ala Asn Gly Val Lys Thr Pro Ile Gln Gly Ser Pro Leu Ala Arg His

660 665 670Ala Phe Phe Leu Glu Val His Asp Thr Leu Tyr Ile His His Phe Gly

675 680 685Arg Ala Tyr Met Asn Tyr Ser Leu Asp Ala Arg Arg Arg Gln Thr Ala

690 695 700His Phe Val Ser Met Gly Leu Asn Arg Ile Phe705 710 715<210>330<211>38<212>DNA<213>沙眼衣原体<400>330gagagcggcc gctcatgaaa tggctgtcag ctactgcg 38<210>331<211>34<212>DNA<213>沙眼衣原体<400>331gagcggccgc ttacttaatg cgaatttctt caag 34<210>332<211>1557<212>DNA<213>沙眼衣原体<400>332atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct catgaaatgg ctgtcagcta ctgcggtgtt tgctgctgtt 480ctcccctcag tttcagggtt ttgcttccca gaacctaaag aattaaattt ctctcgcgta 540gaaacttctt cctctaccac ttttactgaa acaattggag aagctggggc agaatatatc 600gtctctggta acgcatcttt cacaaaattt accaacattc ctactaccga tacaacaact 660cccacgaact caaactcctc tagctctagc ggagaaactg cttccgtttc tgaggatagt 720gactctacaa caacgactcc tgatcctaaa ggtggcggcg ccttttataa cgcgcactcc 780ggagttttgt cctttatgac acgatcagga acagaaggtt ccttaactct gtctgagata 840aaaatgactg gtgaaggcgg tgctatcttc tctcaaggag agctgctatt tacagatctg 900agaagtctaa ccatccaaaa taacttatcc cagctatccg gaggagcgat ttttggagga 960tctacaatct ccctatcagg gattactaaa gcgactttct cctgcaactc tgcagaagtt 1020cctgctcctg ttaagaaacc tacagaacct aaagctcaaa cagcaagcga aacgtcgggt 1080tctagtagtt ctagcggaaa tgattcggtg tcttccccca gttccagtag agctgaaccc 1140gcagcagcta atcttcaaag tcactttatt tgtgctacag ctactcctgc tgctcaaacc 1200gatacagaaa catcaactcc ctctcataag ccaggatctg ggggagctat ctatgctaaa 1260ggcgacctta ctatcgcaga ctctcaagag gtactattct caataaataa agctactaaa 1320gatggaggag cgatctttgc tgagaaagat gtttctttcg agaatattac atcattaaaa 1380gtacaaacta acggtgctga agaaaaggga ggagctatct atgctaaagg tgacctctca 1440attcaatctt ctaaacagag tctttttaat tctaactaca gtaaacaagg tgggggggct 1500ctatatgttg aaggaggtat aaacttccaa gatcttgaag aaattcgcat taagtaa 1557<210>333<211>518<212>PRT<213>沙眼衣原体<400>333Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Met Lys Trp Leu Ser Ala Thr Ala Val Phe Ala Ala Val145 150 155 160Leu Pro Ser Val Ser Gly Phe Cys Phe Pro Glu Pro Lys Glu Leu Asn

165 170 175Phe Ser Arg Val Glu Thr Ser Ser Ser Thr Thr Phe Thr Glu Thr Ile

180 185 190Gly Glu Ala Gly Ala Glu Tyr Ile Val Ser Gly Asn Ala Ser Phe Thr

195 200 205Lys Phe Thr Asn Ile Pro Thr Thr Asp Thr Thr Thr Pro Thr Asn Ser

210 215 220Asn Ser Ser Ser Ser Ser Gly Glu Thr Ala Ser Val Ser Glu Asp Ser225 230 235 240Asp Ser Thr Thr Thr Thr Pro Asp Pro Lys Gly Gly Gly Ala Phe Tyr

245 250 255Asn Ala His Ser Gly Val Leu Ser Phe Met Thr Arg Ser Gly Thr Glu

260 265 270Gly Ser Leu Thr Leu Ser Glu Ile Lys Met Thr Gly Glu Gly Gly Ala

275 280 285Ile Phe Ser Gln Gly Glu Leu Leu Phe Thr Asp Leu Thr Ser Leu Thr

290 295 300Ile Gln Asn Asn Leu Ser Gln Leu Ser Gly Gly Ala Ile Phe Gly Gly305 310 315 320Ser Thr Ile Ser Leu Ser Gly Ile Thr Lys Ala Thr Phe Ser Cys Asn

325 330 335Ser Ala Glu Val Pro Ala Pro Val Lys Lys Pro Thr Glu Pro Lys Ala

340 345 350Gln Thr Ala Ser Glu Thr Ser Gly Ser Ser Ser Ser Ser Gly Asn Asp

355 360 365Ser Val Ser Ser Pro Ser Ser Ser Arg Ala Glu Pro Ala Ala Ala Asn

370 375 380Leu Gln Ser His Phe Ile Cys Ala Thr Ala Thr Pro Ala Ala Gln Thr385 390 395 400Asp Thr Glu Thr Ser Thr Pro Ser His Lys Pro Gly Ser Gly Gly Ala

405 410 415Ile Tyr Ala Lys Gly Asp Leu Thr Ile Ala Asp Ser Gln Glu Val Leu

420 425 430Phe Ser Ile Asn Lys Ala Thr Lys Asp Gly Gly Ala Ile Phe Ala Glu

435 440 445Lys Asp Val Ser Phe Glu Asn Ile Thr Ser Leu Lys Val Gln Thr Asn

450 455 460Gly Ala Glu Glu Lys Gly Gly Ala Ile Tyr Ala Lys Gly Asp Leu Ser465 470 475 480Ile Gln Ser Ser Lys Gln Ser Leu Phe Asn Ser Asn Tyr Ser Lys Gln

485 490 495Gly Gly Gly Ala Leu Tyr Val Glu Gly Gly Ile Asn Phe Gln Asp Leu

500 505 510Glu Glu Ile Arg Ile Lys

515<210>334<211>37<212>DNA<213>沙眼衣原体<400>334gagagcggcc gctcggtgac ctctcaattc aatcttc 37<210>335<211>39<212>DNA<213>沙眼衣原体<400>335gagagcggcc gcttagttct ctgttacaga taaggagac 39<210>336<211>1758<212>DNA<213>沙眼衣原体<400>336atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cggtgacctc tcaattcaat cttctaaaca gagtcttttt 480aattctaact acagtaaaca aggtgggggg gctctatatg ttgaaggagg tataaacttc 540caagatcttg aagaaattcg cattaagtac aataaagctg gaacgttcga aacaaaaaaa 600atcactttac cttctttaaa agctcaagca tctgcaggaa atgcagatgc ttgggcctct 660tcctctcctc aatctggttc tggagcaact acagtctccg actcaggaga ctctagctct 720ggctcagact cggatacctc agaaacagtt ccagtcacag ctaaaggcgg tgggctttat 780actgataaga atctttcgat tactaacatc acaggaatta tcgaaattgc aaataacaaa 840gcgacagatg ttggaggtgg tgcttacgta aaaggaaccc ttacttgtga aaactctcac 900cgtctacaat ttttgaaaaa ctcttccgat aaacaaggtg gaggaatcta cggagaagac 960aacatcaccc tatctaattt gacagggaag actctattcc aagagaatac tgccaaagaa 1020gagggcggtg gactcttcat aaaaggtaca gataaagctc ttacaatgac aggactggat 1080agtttctgtt taattaataa cacatcagaa aaacatggtg gtggagcctt tgttaccaaa 1140gaaatctctc agacttacac ctctgatgtg gaaacaattc caggaatcac gcctgtacat 1200ggtgaaacag tcattactgg caataaatct acaggaggta atggtggagg cgtgtgtaca 1260aaacgtcttg ccttatctaa ccttcaaagc atttctatat ccgggaattc tgcagcagaa 1320aatggtggtg gagcccacac atgcccagat agcttcccaa cggcggatac tgcagaacag 1380cccgcagcag cttctgccgc gacgtctact cccaaatctg ccccggtctc aactgctcta 1440agcacacctt catcttctac cgtctcttca ttaaccttac tagcagcctc ttcacaagcc 1500tctcctgcaa cctctaataa ggaaactcaa gatcctaatg ctgatacaga cttattgatc 1560gattatgtag ttgatacgac tatcagcaaa aacactgcta agaaaggcgg tggaatctat 1620gctaaaaaag ccaagatgtc ccgcatagac caactgaata tctctgagaa ctccgctaca 1680gagataggtg gaggtatctg ctgtaaagaa tctttagaac tagatgctct agtctcctta 1740tctgtaacag agaactaa 1758<210>337<211>585<212>PRT<213>沙眼衣原体<400>337Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Gly Asp Leu Ser Ile Gln Ser Ser Lys Gln Ser Leu Phe145 150 155 160Asn Ser Asn Tyr Ser Lys Gln Gly Gly Gly Ala Leu Tyr Val Glu Gly

165 170 175Gly Ile Asn Phe Gln Asp Leu Glu Glu Ile Arg Ile Lys Tyr Asn Lys

180 185 190Ala Gly Thr Phe Glu Thr Lys Lys Ile Thr Leu Pro Ser Leu Lys Ala

195 200 205Gln Ala Ser Ala Gly Asn Ala Asp Ala Trp Ala Ser Ser Ser Pro Gln

210 215 220Ser Gly Ser Gly Ala Thr Thr Val Ser Asp Ser Gly Asp Ser Ser Ser225 230 235 240Gly Ser Asp Ser Asp Thr Ser Glu Thr Val Pro Val Thr Ala Lys Gly

245 250 255Gly Gly Leu Tyr Thr Asp Lys Asn Leu Ser Ile Thr Asn Ile Thr Gly

260 265 270Ile Ile Glu Ile Ala Asn Asn Lys Ala Thr Asp Val Gly Gly Gly Ala

275 280 285Tyr Val Lys Gly Thr Leu Thr Cys Glu Asn Ser His Arg Leu Gln Phe

290 295 300Leu Lys Asn Ser Ser Asp Lys Gln Gly Gly Gly Ile Tyr Gly Glu Asp305 310 315 320Asn Ile Thr Leu Ser Asn Leu Thr Gly Lys Thr Leu Phe Gln Glu Asn

325 330 335Thr Ala Lys Glu Glu Gly Gly Gly Leu Phe Ile Lys Gly Thr Asp Lys

340 345 350Ala Leu Thr Met Thr Gly Leu Asp Ser Phe Cys Leu Ile Asn Asn Thr

355 360 365Ser Glu Lys His Gly Gly Gly Ala Phe Val Thr Lys Glu Ile Ser Gln

370 375 380Thr Tyr Thr Ser Asp Val Glu Thr Ile Pro Gly Ile Thr Pro Val His385 390 395 400Gly Glu Thr Val Ile Thr Gly Asn Lys Ser Thr Gly Gly Asn Gly Gly

405 410 415Gly Val Cys Thr Lys Arg Leu Ala Leu Ser Asn Leu Gln Ser Ile Ser

420 425 430Ile Ser Gly Asn Ser Ala Ala Glu Asn Gly Gly Gly Ala His Thr Cys

435 440 445Pro Asp Ser Phe Pro Thr Ala Asp Thr Ala Glu Gln Pro Ala Ala Ala

450 455 460Ser Ala Ala Thr Ser Thr Pro Lys Ser Ala Pro Val Ser Thr Ala Leu465 470 475 480Ser Thr Pro Ser Ser Ser Thr Val Ser Ser Leu Thr Leu Leu Ala Ala

485 490 495Ser Ser Gln Ala Ser Pro Ala Thr Ser Asn Lys Glu Thr Gln Asp Pro

500 505 510Asn Ala Asp Thr Asp Leu Leu Ile Asp Tyr Val Val Asp Thr Thr Ile

515 520 525Ser Lys Asn Thr Ala Lys Lys Gly Gly Gly Ile Tyr Ala Lys Lys Ala

530 535 540Lys Met Ser Arg Ile Asp Gln Leu Asn Ile Ser Glu Asn Ser Ala Thr545 550 555 560Glu Ile Gly Gly Gly Ile Cys Cys Lys Glu Ser Leu Glu Leu Asp Ala

565 570 575Leu Val Ser Leu Ser Val Thr Glu Asn

580 585<210>338<211>38<212>DNA<213>沙眼衣原体<400>338gagagcggcc gctcgaccaa ctgaatatct ctgagaac 38<210>339<211>35<212>DNA<213>沙眼衣原体<400>339gagagcggcc gcttaagaga ctacgtggag ttctg 35<210>340<211>1965<212>DNA<213>沙眼衣原体<400>340atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cgaccaactg aatatctctg agaactccgc tacagagata 480ggtggaggta tctgctgtaa agaatcttta gaactagatg ctctagtctc cttatctgta 540acagagaacc ttgttgggaa agaaggtgga ggcttacatg ctaaaactgt aaatatttct 600aatctgaaat caggcttctc tttctcgaac aacaaagcaa actcctcatc cacaggagtc 660gcaacaacag cttcagcacc tgctgcagct gctgcttccc tacaagcagc cgcagcagcc 720gcaccatcat ctccagcaac accaacttat tcaggtgtag taggaggagc tatctatgga 780gaaaaggtta cattctctca atgtagcggg acttgtcagt tctctgggaa ccaagctatc 840gataacaatc cctcccaatc atcgttgaac gtacaaggag gagccatcta tgccaaaacc 900tctttgtcta ttggatcttc cgatgctgga acctcctata ttttctcggg gaacagtgtc 960tccactggga aatctcaaac aacagggcaa atagcgggag gagcgatcta ctcccctact 1020gttacattga attgtcctgc gacattctct aacaatacag cctctatagc tacaccgaag 1080acttcttctg aagatggatc ctcaggaaat tctattaaag ataccattgg aggagccatt 1140gcagggacag ccattaccct atctggagtc tctcgatttt cagggaatac ggctgattta 1200ggagctgcaa taggaactct agctaatgca aatacaccca gtgcaactag cggatctcaa 1260aatagcatta cagaaaaaat tactttagaa aacggttctt ttatttttga aagaaaccaa 1320gctaataaac gtggagcgat ttactctcct agcgtttcca ttaaagggaa taatattacc 1380ttcaatcaaa atacatccac tcatgatgga agcgctatct actttacaaa agatgctacg 1440attgagtctt taggatctgt tctttttaca ggaaataacg ttacagctac acaagctagt 1500tctgcaacat ctggacaaaa tacaaatact gccaactatg gggcagccat ctttggagat 1560ccaggaacca ctcaatcgtc tcaaacagat gccattttaa cccttcttgc ttcttctgga 1620aacattactt ttagcaacaa cagtttacag aataaccaag gtgatactcc cgctagcaag 1680ttttgtagta ttgcaggata cgtcaaactc tctctacaag ccgctaaagg gaagactatt 1740agctttttcg attgtgtgca cacctctacc aaaaaaacag gttcaacaca aaacgtttat 1800gaaactttag atattaataa agaagagaac agtaatccat atacaggaac tattgtgttc 1860tcttctgaat tacatgaaaa caaatcttac atcccacaga atgcaatcct tcacaacgga 1920actttagttc ttaaagagaa aacagaactc cacgtagtct cttaa 1965<210>341<211>654<212>PRT<213>沙眼衣原体<400>341Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Asp Gln Leu Asn Ile Ser Glu Asn Ser Ala Thr Glu Ile145 150 155 160Gly Gly Gly Ile Cys Cys Lys Glu Ser Leu Glu Leu Asp Ala Leu Val

165 170 175Ser Leu Ser Val Thr Glu Asn Leu Val Gly Lys Glu Gly Gly Gly Leu

180 185 190His Ala Lys Thr Val Asn Ile Ser Asn Leu Lys Ser Gly Phe Ser Phe

195 200 205Ser Asn Asn Lys Ala Asn Ser Ser Ser Thr Gly Val Ala Thr Thr Ala

210 215 220Ser Ala Pro Ala Ala Ala Ala Ala Ser Leu Gln Ala Ala Ala Ala Ala225 230 235 240Ala Pro Ser Ser Pro Ala Thr Pro Thr Tyr Ser Gly Val Val Gly Gly

245 250 255Ala Ile Tyr Gly Glu Lys Val Thr Phe Ser Gln Cys Ser Gly Thr Cys

260 265 270Gln Phe Ser Gly Asn Gln Ala Ile Asp Asn Asn Pro Ser Gln Ser Ser

275 280 285Leu Asn Val Gln Gly Gly Ala Ile Tyr Ala Lys Thr Ser Leu Ser Ile

290 295 300Gly Ser Ser Asp Ala Gly Thr Ser Tyr Ile Phe Ser Gly Asn Ser Val305 310 315 320Ser Thr Gly Lys Ser Gln Thr Thr Gly Gln Ile Ala Gly Gly Ala Ile

325 330 335Tyr Ser Pro Thr Val Thr Leu Asn Cys Pro Ala Thr Phe Ser Asn Asn

340 345 350Thr Ala Ser Ile Ala Thr Pro Lys Thr Ser Ser Glu Asp Gly Ser Ser

355 360 365Gly Asn Ser Ile Lys Asp Thr Ile Gly Gly Ala Ile Ala Gly Thr Ala

370 375 380Ile Thr Leu Ser Gly Val Ser Arg Phe Ser Gly Asn Thr Ala Asp Leu385 390 395 400Gly Ala Ala Ile Gly Thr Leu Ala Asn Ala Asn Thr Pro Ser A1a Thr

405 410 415Ser Gly Ser Gln Asn Ser Ile Thr Glu Lys Ile Thr Leu Glu Asn Gly

420 425 430Ser Phe Ile Phe Glu Arg Asn Gln Ala Asn Lys Arg Gly Ala Ile Tyr

435 440 445Ser Pro Ser Val Ser Ile Lys Gly Asn Asn Ile Thr Phe Asn Gln Asn

450 455 460Thr Ser Thr His Asp Gly Ser Ala Ile Tyr Phe Thr Lys Asp Ala Thr465 470 475 480Ile Glu Ser Leu Gly Ser Val Leu Phe Thr Gly Asn Asn Val Thr Ala

485 490 495Thr Gln Ala Ser Ser Ala Thr Ser Gly Gln Asn Thr Asn Thr Ala Asn

500 505 510Tyr Gly Ala Ala Ile Phe Gly Asp Pro Gly Thr Thr Gln Ser Ser Gln

515 520 525Thr Asp Ala Ile Leu Thr Leu Leu Ala Ser Ser Gly Asn Ile Thr Phe

530 535 540Ser Asn Asn Ser Leu Gln Asn Asn Gln Gly Asp Thr Pro Ala Ser Lys545 550 555 560Phe Cys Ser Ile Ala Gly Tyr Val Lys Leu Ser Leu Gln Ala Ala Lys

565 570 575Gly Lys Thr Ile Ser Phe Phe Asp Cys Val His Thr Ser Thr Lys Lys

580 585 590Thr Gly Ser Thr Gln Asn Val Tyr Glu Thr Leu Asp Ile Asn Lys Glu

595 600 605Glu Asn Ser Asn Pro Tyr Thr Gly Thr Ile Val Phe Ser Ser Glu Leu

610 615 620His Glu Asn Lys Ser Tyr Ile Pro Gln Asn Ala Ile Leu His Asn Gly625 630 635 640Thr Leu Val Leu Lys Glu Lys Thr Glu Leu His Val Val Ser

645 650<210>342<211>36<212>DNA<213>沙眼衣原体<400>342gagagcggcc gctcggaact attgtgttct cttctg 36<210>343<211>35<212>DNA<213>沙眼衣原体<400>343gagagcggcc gcttagaaga tcatgcgagc accgc 35<210>344<211>2103<212>DNA<213>沙眼衣原体<400>344atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cggaactatt gtgttctctt ctgaattaca tgaaaacaaa 480tcttacatcc cacagaatgc aatccttcac aacggaactt tagttcttaa agagaaaaca 540gaactccacg tagtctcttt tgagcagaaa gaagggtcta aattaattat ggaacccgga 600gctgtgttat ctaaccaaaa catagctaac ggagctctag ctatcaatgg gttaacgatt 660gatctttcca gtatggggac tcctcaagca ggggaaatct tctctcctcc agaattacgt 720atcgttgcca cgacctctag tgcatccgga ggaagcgggg tcagcagtag tataccaaca 780aatcctaaaa ggatttctgc agcagtgcct tcaggttctg ccgcaactac tccaactatg 840agcgagaaca aagttttcct aacaggagac cttactttaa tagatcctaa tggaaacttt 900taccaaaacc ctatgttagg aagcgatcta gatgtaccac taattaagct tccgactaac 960acaagtgacg tccaagtcta tgatttaact ttatctgggg atcttttccc tcagaaaggg 1020tacatgggaa cctggacatt agattctaat ccacaaacag ggaaacttca agccagatgg 1080acattcgata cctatcgtcg ctgggtatac atacctaggg ataatcattt ttatgcgaac 1140tctatcttag gctcccaaaa ctcaatgatt gttgtgaagc aagggcttat caacaacatg 1200ttgaataatg cccgcttcga tgatatcgct tacaataact tctgggtttc aggagtagga 1260actttcttag ctcaacaagg aactcctctt tccgaagaat tcagttacta cagccgcgga 1320acttcagttg ccatcgatgc caaacctaga caagatttta tcctaggagc tgcatttagt 1380aagatagtgg ggaaaaccaa agccatcaaa aaaatgcata attacttcca taagggctct 1440gagtactctt accaagcttc tgtctatgga ggtaaattcc tgtatttctt gctcaataag 1500caacatggtt gggcacttcc tttcctaata caaggagtcg tgtcctatgg acatattaaa 1560catgatacaa caacacttta cccttctatc catgaaagaa ataaaggaga ttgggaagat 1620ttaggatggt tagcggatct tcgtatctct atggatctta aagaaccttc taaagattct 1680tctaaacgga tcactgtcta tggggaactc gagtattcca gcattcgcca gaaacagttc 1740acagaaatcg attacgatcc aagacacttc gatgattgtg cttacagaaa tctgtcgctt 1800cctgtgggat gcgctgtcga aggagctatc atgaactgta atattcttat gtataataag 1860cttgcattag cctacatgcc ttctatctac agaaataatc ctgtctgtaa atatcgggta 1920ttgtcttcga atgaagctgg tcaagttatc tgcggagtgc caactagaac ctctgctaga 1980gcagaataca gtactcaact atatcttggt cccttctgga ctctctacgg aaactatact 2040atcgatgtag gcatgtatac gctatcgcaa atgactagct gcggtgctcg catgatcttc 2100taa 2103<2l0>345<211>700<212>PRT<213>沙眼衣原体<400>345Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Gly Thr Ile Val Phe Ser Ser Glu Leu His Glu Asn Lys145 150 155 160Ser Tyr Ile Pro Gln Asn Ala Ile Leu His Asn Gly Thr Leu Val Leu

165 170 175Lys Glu Lys Thr Glu Leu His Val Val Ser Phe Glu Gln Lys Glu Gly

180 185 190Ser Lys Leu Ile Met Glu Pro Gly Ala Val Leu Ser Asn Gln Asn Ile

195 200 205Ala Asn Gly Ala Leu Ala Ile Asn Gly Leu Thr Ile Asp Leu Ser Ser

210 215 220Met Gly Thr Pro Gln Ala Gly Glu Ile Phe Ser Pro Pro Glu Leu Arg225 230 235 240Ile Val Ala Thr Thr Ser Ser Ala Ser Gly Gly Ser Gly Val Ser Ser

245 250 255Ser Ile Pro Thr Asn Pro Lys Arg Ile Ser Ala Ala Val Pro Ser Gly

260 265 270Ser Ala Ala Thr Thr Pro Thr Met Ser Glu Asn Lys Val Phe Leu Thr

275 280 285Gly Asp Leu Thr Leu Ile Asp Pro Asn Gly Asn Phe Tyr Gln Asn Pro

290 295 300Met Leu Gly Ser Asp Leu Asp Val Pro Leu Ile Lys Leu Pro Thr Asn305 310 315 320Thr Ser Asp Val Gln Val Tyr Asp Leu Thr Leu Ser Gly Asp Leu Phe

325 330 335Pro Gln Lys Gly Tyr Met Gly Thr Trp Thr Leu Asp Ser Asn Pro Gln

340 345 350Thr Gly Lys Leu Gln Ala Arg Trp Thr Phe Asp Thr Tyr Arg Arg Trp

355 360 365yal Tyr Ile Pro Arg Asp Asn His Phe Tyr Ala Asn Ser Ile Leu Gly

370 375 380Ser Gln Asn Ser Met Ile Val Val Lys Gln Gly Leu Ile Asn Asn Met385 390 395 400Leu Asn Asn Ala Arg Phe Asp Asp Ile Ala Tyr Asn Asn Phe Trp Val

405 410 415Ser Gly Val Gly Thr Phe Leu Ala Gln Gln Gly Thr Pro Leu Ser Glu

420 425 430Glu Phe Ser Tyr Tyr Ser Arg Gly Thr Ser Val Ala Ile Asp Ala Lys

435 440 445Pro Arg Gln Asp Phe Ile Leu Gly Ala Ala Phe Ser Lys Ile Val Gly

450 455 460Lys Thr Lys Ala Ile Lys Lys Met His Asn Tyr Phe His Lys Gly Ser465 470 475 480Glu Tyr Ser Tyr Gln Ala Ser Val Tyr Gly Gly Lys Phe Leu Tyr Phe

485 490 495Leu Leu Asn Lys Gln His Gly Trp Ala Leu Pro Phe Leu Ile Gln Gly

500 505 510Val Val Ser Tyr Gly His Ile Lys His Asp Thr Thr Thr Leu Tyr Pro

515 520 525Ser Ile His Glu Arg Asn Lys Gly Asp Trp Glu Asp Leu Gly Trp Leu

530 535 540Ala Asp Leu Arg Ile Ser Met Asp Leu Lys Glu Pro Ser Lys Asp Ser545 550 555 560Ser Lys Arg Ile Thr Val Tyr Gly Glu Leu Glu Tyr Ser Ser Ile Arg

565 570 575Gln Lys Gln Phe Thr Glu Ile Asp Tyr Asp Pro Arg His Phe Asp Asp

580 585 590Cys Ala Tyr Arg Asn Leu Ser Leu Pro VaL Gly Cys Ala Val Glu Gly

595 600 605Ala Ile Met Asn Cys Asn Ile Leu Met Tyr Asn Lys Leu Ala Leu Ala

610 615 620Tyr Met Pro Ser Ile Tyr Arg Asn Asn Pro Val Cys Lys Tyr Arg Val625 630 635 640Leu Ser Ser Asn Glu Ala Gly Gln Val Ile Cys Gly Val Pro Thr Arg

645 650 655Thr Ser Ala Arg Ala Glu Tyr Ser Thr Gln Leu Tyr Leu Gly Pro Phe

660 665 670Trp Thr Leu Tyr Gly Asn Tyr Thr Ile Asp Val Gly Met Tyr Thr Leu

675 680 685Ser Gln Met Thr Ser Cys Gly Ala Arg Met Ile Phe

690 695 700<210>346<211>37<212>DNA<213>沙眼衣原体<400>346gagagcggcc gctcatgaaa tttatgtcag ctactgc 37<210>347<211>37<212>DNA<213>沙眼衣原体<400>347gagagcggcc gcttaccctg taattccagt gatggtc 37<210>348<211>1464<212>DNA<213>沙眼衣原体<400>348atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct catgaaattt atgtcagcta ctgctgtatt tgctgcagta 480ctctcctccg ttactgaggc gagctcgatc caagatcaaa taaagaatac cgactgcaat 540gttagcaaag taggatattc aacttctcaa gcatttactg atatgatgct agcagacaac 600acagagtatc gagctgctga tagtgtttca ttctatgact tttcgacatc ttccggatta 660cctagaaaac atcttagtag tagtagtgaa gcttctccaa cgacagaagg agtgtcttca 720tcttcatctg gagaaaatac tgagaattca caagattcag ctccctcttc tggagaaact 780gataagaaaa cagaagaaga actagacaat ggcggaatca tttatgctag agagaaacta 840actatctcag aatctcagga ctctctctct aatccaagca tagaactcca tgacaatagt 900tttttcttcg gagaaggtga agttatcttt gatcacagag ttgccctcaa aaacggagga 960gctatttatg gagagaaaga ggtagtcttt gaaaacataa aatctctact agtagaagta 1020aatatctcgg tcgagaaagg gggtagcgtc tatgcaaaag aacgagtatc tttagaaaat 1080gttaccgaag caaccttctc ctccaatggt ggggaacaag gtggtggtgg aatctattca 1140gaacaagata tgttaatcag tgattgcaac aatgtacatt tccaagggaa tgctgcagga 1200gcaacagcag taaaacaatg tctggatgaa gaaatgatcg tattgctcac agaatgcgtt 1260gatagcttat ccgaagatac actggatagc actccagaaa cggaacagac taagtcaaat 1320ggaaatcaag atggttcgtc tgaaacaaaa gatacacaag tatcagaatc accagaatca 1380actcctagcc ccgacgatgt tttaggtaaa ggtggtggta tctatacaga aaaatctttg 1440accatcactg gaattacagg gtaa 1464<210>349<211>487<212>PRT<213>沙眼衣原体<400>349Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

l00 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Met Lys Phe Met Ser Ala Thr Ala Val Phe Ala Ala Val145 150 155 160Leu Ser Ser Val Thr Glu Ala Ser Ser Ile Gln Asp Gln Ile Lys Asn

165 170 175Thr Asp Cys Asn Val Ser Lys Val Gly Tyr Ser Thr Ser Gln Ala Phe

180 185 190Thr Asp Met Met Leu Ala Asp Asn Thr Glu Tyr Arg Ala Ala Asp Ser

195 200 205Val Ser Phe Tyr Asp Phe Ser Thr Ser Ser Gly Leu Pro Arg Lys His

210 215 220Leu Ser Ser Ser Ser Glu Ala Ser Pro Thr Thr Glu Gly Val Ser Ser225 230 235 240Ser Ser Ser Gly Glu Asn Thr Glu Asn Ser Gln Asp Ser Ala Pro Ser

245 250 255Ser Gly Glu Thr Asp Lys Lys Thr Glu Glu Glu Leu Asp Asn Gly Gly

260 265 270Ile Ile Tyr Ala Arg Glu Lys Leu Thr Ile Ser Glu Ser Gln Asp Ser

275 280 285Leu Ser Asn Pro Ser Ile Glu Leu His Asp Asn Ser Phe Phe Phe Gly

290 295 300Glu Gly Glu Val Ile Phe Asp His Arg Val Ala Leu Lys Asn Gly Gly305 310 315 320Ala Ile Tyr Gly Glu Lys Glu Val Val Phe Glu Asn Ile Lys Ser Leu

325 330 335Leu Val Glu Val Asn Ile Ser Val Glu Lys Gly Gly Ser Val Tyr Ala

340 345 350Lys Glu Arg Val Ser Leu Glu Asn Val Thr Glu Ala Thr Phe Ser Ser

355 360 365Asn Gly Gly Glu Gln Gly Gly Gly Gly Ile Tyr Ser Glu Gln Asp Met

370 375 380Leu Ile Ser Asp Cys Asn Asn Val His Phe Gln Gly Asn Ala Ala Gly385 390 395 400Ala Thr Ala Val Lys Gln Cys Leu Asp Glu Glu Met Ile Val Leu Leu

405 410 415Thr Glu Cys Val Asp Ser Leu Ser Glu Asp Thr Leu Asp Ser Thr Pro

420 425 430Glu Thr Glu Gln Thr Lys Ser Asn Gly Asn Gln Asp Gly Ser Ser Glu

435 440 445Thr Lys Asp Thr Gln Val Ser Glu Ser Pro Glu Ser Thr Pro Ser Pro

450 455 460Asp Asp Val Leu Gly Lys Gly Gly Gly Ile Tyr Thr Glu Lys Ser Leu465 470 475 480Thr Ile Thr Gly Ile Thr Gly

485<210>350<211>37<212>DNA<213>沙眼衣原体<400>350gagagcggcc gctcgataca caagtatcag aatcacc 37<210>351<211>37<212>DNA<213>沙眼衣原体<400>351gagagcggcc gcttaagagg acgatgagac actctcg 37<210>352<211>1752<212>DNA<213>沙眼衣原体<400>352atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cgatacacaa gtatcagaat caccagaatc aactcctagc 480cccgacgatg ttttaggtaa aggtggtggt atctatacag aaaaatcttt gaccatcact 540ggaattacag ggactataga ttttgtcagt aacatagcta ccgattctgg agcaggtgta 600ttcactaaag aaaacttgtc ttgcaccaac acgaatagcc tacagttttt gaaaaactcg 660gcaggtcaac atggaggagg agcctacgtt actcaaacca tgtctgttac taatacaact 720agtgaaagta taactactcc ccctctcgta ggagaagtga ttttctctga aaatacagct 780aaagggcacg gtggtggtat ctgcactaac aaactttctt tatctaattt aaaaacggtg 840actctcacta aaaactctgc aaaggagtct ggaggagcta tttttacaga tctagcgtct 900ataccaacaa cagatacccc agagtcttct accccctctt cctcctcgcc tgcaagcact 960cccgaagtag ttgcttctgc taaaataaat cgattctttg cctctacggc agaaccggca 1020gccccttctc taacagaggc tgagtctgat caaacggatc aaacagaaac ttctgatact 1080aatagcgata tagacgtgtc gattgagaac attttgaatg tcgctatcaa tcaaaacact 1140tctgcgaaaa aaggaggggc tatttacggg aaaaaagcta aactttcccg tattaacaat 1200cttgaacttt cagggaattc atcccaggat gtaggaggag gtctctgttt aactgaaagc 1260gtagaatttg atgcaattgg atcgctctta tcccactata actctgctgc taaagaaggt 1320ggggttattc attctaaaac ggttactcta tctaacctca agtctacctt cacttttgca 1380gataacactg ttaaagcaat agtagaaagc actcctgaag ctccagaaga gattcctcca 1440gtagaaggag aagagtctac agcaacagaa aatccgaatt ctaatacaga aggaagttcg 1500gctaacacta accttgaagg atctcaaggg gatactgctg atacagggac tggtgttgtt 1560aacaatgagt ctcaagacac atcagatact ggaaacgctg aatctggaga acaactacaa 1620gattctacac aatctaatga agaaaatacc cttcccaata gtagtattga tcaatctaac 1680gaaaacacag acgaatcatc tgatagccac actgaggaaa taactgacga gagtgtctca 1740tcgtcctctt aa 1752<210>353<211>583<212>PRT<213>沙眼衣原体<400>353Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Asp Thr Gln Val Ser Glu Ser Pro Glu Ser Thr Pro Ser145 150 155 160Pro Asp Asp Val Leu Gly Lys Gly Gly Gly Ile Tyr Thr Glu Lys Ser

165 170 175Leu Thr Ile Thr Gly Ile Thr Gly Thr Ile Asp Phe Val Ser Asn Ile

180 185 190Ala Thr Asp Ser Gly Ala Gly Val Phe Thr Lys Glu Asn Leu Ser Cys

195 200 205Thr Asn Thr Asn Ser Leu Gln Phe Leu Lys Asn Ser Ala Gly Gln His

210 215 220Gly Gly Gly Ala Tyr Val Thr Gln Thr Met Ser Val Thr Asn Thr Thr225 230 235 240Ser Glu Ser Ile Thr Thr Pro Pro Leu Val Gly Glu Val Ile Phe Ser

245 250 255Glu Asn Thr Ala Lys Gly His Gly Gly Gly Ile Cys Thr Asn Lys Leu

260 265 270Ser Leu Ser Asn Leu Lys Thr Val Thr Leu Thr Lys Asn Ser Ala Lys

275 280 285Glu Ser Gly Gly Ala Ile Phe Thr Asp Leu Ala Ser Ile Pro Thr Thr

290 295 300Asp Thr Pro Glu Ser Ser Thr Pro Ser Ser Ser Ser Pro Ala Ser Thr305 310 315 320Pro Glu Val Val Ala Ser Ala Lys Ile Asn Arg Phe Phe Ala Ser Thr

325 330 335Ala Glu Pro Ala Ala Pro Ser Leu Thr Glu Ala Glu Ser Asp Gln Thr

340 345 350Asp Gln Thr Glu Thr Ser Asp Thr Asn Ser Asp Ile Asp Val Ser Ile

355 360 365Glu Asn Ile Leu Asn Val Ala Ile Asn Gln Asn Thr Ser Ala Lys Lys

370 375 380Gly Gly Ala Ile Tyr Gly Lys Lys Ala Lys Leu Ser Arg Ile Asn Asn385 390 395 400Leu Glu Leu Ser Gly Asn Ser Ser Gln Asp Val Gly Gly Gly Leu Cys

405 410 415Leu Thr Glu Ser Val Glu Phe Asp Ala Ile Gly Ser Leu Leu Ser His

420 425 430Tyr Asn Ser Ala Ala Lys Glu Gly Gly Val Ile His Ser Lys Thr Val

435 440 445Thr Leu Ser Asn Leu Lys Ser Thr Phe Thr Phe Ala Asp Asn Thr Val

450 455 460Lys Ala Ile Val Glu Ser Thr Pro Glu Ala Pro Glu Glu Ile Pro Pro465 470 475 480Val Glu Gly Glu Glu Ser Thr Ala Thr Glu Asn Pro Asn Ser Asn Thr

485 490 495Glu Gly Ser Ser Ala Asn Thr Asn Leu Glu Gly Ser Gln Gly Asp Thr

500 505 510Ala Asp Thr Gly Thr Gly Val Val Asn Asn Glu Ser Gln Asp Thr Ser

515 520 525Asp Thr Gly Asn Ala Glu Ser Gly Glu Gln Leu Gln Asp Ser Thr Gln

530 535 540Ser Asn Glu Glu Asn Thr Leu Pro Asn Ser Ser Ile Asp Gln Ser Asn545 550 555 560Glu Asn Thr Asp Glu Ser Ser Asp Ser His Thr Glu Glu Ile Thr Asp

565 570 575Glu Ser Val Ser Ser Ser Ser

580<210>354<211>39<212>DNA<213>沙眼衣原体<400>354gagagcggcc gctcgatcaa tctaacgaaa acacagacg 39<210>355<211>36<212>DNA<213>沙眼衣原体<400>355gagagcggcc gcttagacca aagctccatc agcaac 36<210>356<211>2052<212>DNA<213>沙眼衣原体<400>356atgcatcacc atcaccatca cacggccgcg tccgataact tccagctgtc ccagggtggg 60cagggattcg ccattccgat cgggcaggcg atggcgatcg cgggccagat caagcttccc 120accgttcata tcgggcctac cgccttcctc ggcttgggtg ttgtcgacaa caacggcaac 180ggcgcacgag tccaacgcgt ggtcgggagc gctccggcgg caagtctcgg catctccacc 240ggcgacgtga tcaccgcggt cgacggcgct ccgatcaact cggccaccgc gatggcggac 300gcgcttaacg ggcatcatcc cggtgacgtc atctcggtga cctggcaaac caagtcgggc 360ggcacgcgta cagggaacgt gacattggcc gagggacccc cggccgaatt ctgcagatat 420ccatcacact ggcggccgct cgatcaatct aacgaaaaca cagacgaatc atctgatagc 480cacactgagg aaataactga cgagagtgtc tcatcgtcct ctaaaagtgg atcatctact 540cctcaagatg gaggagcagc ttcttcaggg gctccctcag gagatcaatc tatctctgca 600aacgcttgtt tagctaaaag ctatgctgcg agtactgata gctcccctgt atctaattct 660tcaggttcag acgttactgc atcttctgat aatccagact cttcctcatc tggagatagc 720gctggagact ctgaaggacc gactgagcca gaagctggtt ctacaacaga aactcctact 780ttaataggag gaggwgctat ctatggagaa actgttaaga ttgagaactt ctctggccaa 840ggaatatttt ctggaaacaa agctatcgat aacaccacag aaggctcctc ttccaaatct 900aacgtcctcg gaggtgcggt ctatgctaaa acattgttta atctcgatag cgggagctct 960agacgaactg tcaccttctc cgggaatact gtctcttctc aatctacaac aggtcaggtt 1020gctggaggag ctatctactc tcctactgta accattgcta ctcctgtagt attttctaaa 1080aactctgcaa caaacaatgc taataacgct acagatactc agagaaaaga cacctttgga 1140ggagctatcg gagctacttc tgctgtttct ctatcaggag gggctcattt cttagaaaac 1200gttgctgacc tcggatctgc tattgggttg gtgccagaca cacaaaatac agaaacagtg 1260aaattagagt ctggctccta ctactttgaa aaaaataaag ctttaaaacg agctactatt 1320tacgcacctg tcgtttccat taaagcctat actgcgacat ttaaccaaaa cagatctcta 1380gaagaaggaa gcgcgattta ctttacaaaa gaagcatcta ttgagtcttt aggctctgtt 1440ctcttcacag gaaacttagt aaccccaacg ctaagcacaa ctacagaagg cacaccagcc 1500acaacctcag gagatgtaac aaaatatggt gctgctatct ttggacaaat agcaagctca 1560aacggatctc agacggataa ccttcccctg aaactcattg cttcaggagg aaatatttgt 1620ttccgaaaca atgaataccg tcctacttct tctgataccg gaacctctac tttctgtagt 1680attgcgggag atgttaaatt aaccatgcaa gctgcaaaag ggaaaacgat cagtttcttt 1740gatgcaatcc ggacctctac taagaaaaca ggtacacagg caactgccta cgatactctc 1800gatattaata aatctgagga ttcagaaact gtaaactctg cgtttacagg aacgattctg 1860ttctcctctg aattacatga aaataaatcc tatattccac aaaacgtagt tctacacagt 1920ggatctcttg tattgaagcc aaataccgag cttcatgtca tttcttttga gcagaaagaa 1980ggctcttctc tcgttatgac acctggatct gttctttcga accagactgt tgctgatgga 2040gctttggtct aa 2052<210>357<211>683<212>PRT<213>沙眼衣原体<400>357Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu1 5 10 15Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala

20 25 30Ile Ala Gly Gln Ile Lys Leu Pro Thr Val His Ile Gly Pro Thr Ala

35 40 45Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val

85 90 95Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser

100 105 110Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr

115 120 125Leu Ala Glu Gly Pro Pro Ala Glu Phe Cys Arg Tyr Pro Ser His Trp

130 135 140Arg Pro Leu Asp Gln Ser Asn Glu Asn Thr Asp Glu Ser Ser Asp Ser145 150 155 160His Thr Glu Glu Ile Thr Asp Glu Ser Val Ser Ser Ser Ser Lys Ser

165 170 175Gly Ser Ser Thr Pro Gln Asp Gly Gly Ala Ala Ser Ser Gly Ala Pro

180 185 190Ser Gly Asp Gln Ser Ile Ser Ala Asn Ala Cys Leu Ala Lys Ser Tyr

195 200 205Ala Ala Ser Thr Asp Ser Ser Pro Val Ser Asn Ser Ser Gly Ser Asp

210 215 220Val Thr Ala Ser Ser Asp Asn Pro Asp Ser Ser Ser Ser Gly Asp Ser225 230 235 240Ala Gly Asp Ser Glu Gly Pro Thr Glu Pro Glu Ala Gly Ser Thr Thr

245 250 255Glu Thr Pro Thr Leu Ile Gly Gly Gly Ala Ile Tyr Gly Glu Thr Val

260 265 270Lys Ile Glu Asn Phe Ser Gly Gln Gly Ile Phe Ser Gly Asn Lys Ala

275 280 285Ile Asp Asn Thr Thr Glu Gly Ser Ser Ser Lys Ser Asn Val Leu Gly

290 295 300Gly Ala Val Tyr Ala Lys Thr Leu Phe Asn Leu Asp Ser Gly Ser Ser305 310 315 320Arg Arg Thr Val Thr Phe Ser Gly Asn Thr Val Ser Ser Gln Ser Thr

325 330 335Thr Gly Gln Val Ala Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr Ile

340 345 350Ala Thr Pro Val Val Phe Ser Lys Asn Ser Ala Thr Asn Asn Ala Asn

355 360 365Asn Ala Thr Asp Thr Gln Arg Lys Asp Thr Phe Gly Gly Ala Ile Gly

370 375 380Ala Thr Ser Ala Val Ser Leu Ser Gly Gly Ala His Phe Leu Glu Asn385 390 395 400Val Ala Asp Leu Gly Ser Ala Ile Gly Leu Val Pro Asp Thr Gln Asn

405 410 415Thr Glu Thr Val Lys Leu Glu Ser Gly Ser Tyr Tyr Phe Glu Lys Asn

420 425 430Lys Ala Leu Lys Arg Ala Thr Ile Tyr Ala Pro Val Val Ser Ile Lys

435 440 445Ala Tyr Thr Ala Thr Phe Asn Gln Asn Arg Ser Leu Glu Glu Gly Ser

450 455 460Ala Ile Tyr Phe Thr Lys Glu Ala Ser Ile Glu Ser Leu Gly Ser Val465 470 475 480Leu Phe Thr Gly Asn Leu Val Thr Pro Thr Leu Ser Thr Thr Thr Glu

485 490 495Gly Thr Pro Ala Thr Thr Ser Gly Asp Val Thr Lys Tyr Gly Ala Ala

500 505 510Ile Phe Gly Gln Ile Ala Ser Ser Asn Gly Ser Gln Thr Asp Asn Leu

515 520 525Pro Leu Lys Leu Ile Ala Ser Gly Gly Asn Ile Cys Phe Arg Asn Asn

530 535 540Glu Tyr Arg Pro Thr Ser Ser Asp Thr Gly Thr Ser Thr Phe cys Ser545 550 555 560Ile Ala Gly Asp Val Lys Leu Thr Met Gln Ala Ala Lys Gly Lys Thr

565 570 575Ile Ser Phe Phe Asp Ala Ile Arg Thr Ser Thr Lys Lys Thr Gly Thr

580 585 590Gln Ala Thr Ala Tyr Asp Thr Leu Asp Ile Asn Lys Ser Glu Asp Ser

595 600 605Glu Thr Val Asn Ser Ala Phe Thr Gly Thr Ile Leu Phe Ser Ser Glu

610 615 620Leu His Glu Asn Lys Ser Tyr Ile Pro Gln Asn Val Val Leu His Ser625 630 635 640Gly Ser Leu Val Leu Lys Pro Asn Thr Glu Leu His Val Ile Ser Phe

645 650 655Glu Gln Lys Glu Gly Ser Ser Leu Val Met Thr Pro Gly Ser Val Leu

660 665 670Ser Asn Gln Thr Val Ala Asp Gly Ala Leu Val

675 680<210>358<211>1248<212>DNA<213>衣原体属<400>358catatgcatc accatcacca tcaccctcca gaatcgggct taatcatagc cattcacgat 60gatcctcgct ctctttctcc agaaaaagga gaaaatgctt tccatttttc tttgtccaag 120gctttatttg ctactctctt cagagaagag ctctctggat taacccctgc tctggtctcc 180tcctatcaag tttcggaaga cgggcggttt tatcgttttt gtattcgtaa agatgctaag 240tggagtgacg gctctctttt acttgcagaa gatgtaatag ctgcttggga acacactaaa 300caagctgggc gatattccct actttttgaa aagctatctt ttcgagcctc ttcttcttcg 360gaaatcctta ttgaactcaa agaacccgag cctcaactat tggcgatatt agcctctccg 420ttttttgctg tgtatcgtcc agaaaatcct ttctttctt ctggaccttt tatgccaaaa 480acctatgtgc aagggcaaac gctcgttcta caaaaaaacc cttattacta tgaccatgcg 540catgtggaat tacattccat agactttcgc atcattccca acatttacac agctctacac 600ctcttaagaa gaggtgacgt ggattgggtg gggcagcctt ggcaccaagg gattcctttt 660gagcttcgga ctacctctgc tctctacacc cattaccctg tagatggcac attctggctt 720attcttaatc ccaaagatcc tgtactttcc tctctatcta atcgtcagcg attgattgct 780gccatccaaa aggaaaaact ggtgaagcaa gctttaggaa cacaatatcg agtagctgaa 840agctctccat ctccagaggg aatcatagct catcaagaag cttctactcc ttttcctggg 900aaaattactt tgatatatcc caataatatt acgcgctgtc agcgtttggc cgaggtattg 960caagaacaat gccgagacgc aggtatccag ctgactcttg aaggactcga ataccatgta 1020tttgttcaaa aacgagccac tcaagatttc tctgtctcca cagcaacttc tatagctttc 1080catccccttg ctaaatctaa gttcgatcaa acggctctag acaatttcac ttgtctgccc 1140ttgtaccaca tagaatatga ttatattttg agcagaccgc tagatcaaat tgttcactat 1200ccttcaggta gtgttgattt gacctatgca cactttcact aggaattc 1248<210>359<211>1311<212>DNA<213>衣原体属<400>359catatgcatc accatcacca tcacatgtat gttcgctcta tcttttttag tattatcgcc 60ttcctaacgg tcggatgctc cttttctcct ccagaatcgg gcttaatcat agccattcac 120gatgatcctc gctctctttc tccagaaaaa ggagaaaatg ctttccattt ttctttgtcc 180aaggctttat ttgctactct cttcagagaa gagctctctg gattaacccc tgctctggtc 240tcctcctatc aagtttcgga agacgggcgg ttttatcgtt tttgtattcg taaagatgct 300aagtggagtg acggctctct tttacttgca gaagatgtaa tagctgcttg ggaacacact 360aaacaagctg ggcgatattc cctacttttt gaaaagctat cttttcgagc ctcttcttct 420tcggaaatcc ttattgaact caaagaaccc gagcctcaac tattggcgat attagcctct 480ccgttttttg ctgtgtatcg tccagaaaat ccttttcttt cttctggacc ttttatgcca 540aaaacctatg tgcaagggca aacgctcgtt ctacaaaaaa acccttatta ctatgaccat 600gcgcatgtgg aattacattc catagacttt cgcatcattc ccaacattta cacagctcta 660cacctcttaa gaagaggtga cgtggattgg gtggggcagc cttggcacca agggattcct 720tttgagcttc ggactacctc tgctctctac acccattacc ctgtagatgg cacattctgg 780cttattctta atcccaaaga tcctgtactt tcctctctat ctaatcgtca gcgattgatt 840gctgccatcc aaaaggaaaa actggtgaag caagctttag gaacacaata tcgagtagct 900gaaagctctc catctccaga gggaatcata gctcatcaag aagcttctac tccttttcct 960gggaaaatta ctttgatata tcccaataat attacgcgct gtcagcgttt ggccgaggta 1020ttgcaagaac aatgccgaga cgcaggtatc cagctgactc ttgaaggact cgaataccat 1080gtatttgttc aaaaacgagc cactcaagat ttctctgtct ccacagcaac ttctatagct 1140ttccatcccc ttgctaaatc taagttcgat caaacggctc tagacaattt cacttgtctg 1200cccttgtacc acatagaata tgattatatt ttgagcagac cgctagatca aattgttcac 1260tatccttcag gtagtgttga tttgacctat gcacactttc actaggaatt c 1311<210>360<211>813<212>DNA<213>衣原体属<400>360atgcatcacc atcaccatca cggaaattct ggtttttatt tgtataacac tcaaaactgc 60gtctttgctg ataatatcaa agttgggcaa atgacagagc cgctcaagga ccagcaaata 120atccttggga caacatcaac acctgtcgca gccaaaatga cagcttctga tggaatatct 180ttaacagtct ccaataatcc atcaaccaat gcttctatta caattggttt ggatgcggaa 240aaagcttacc agcttattct agaaaagttg ggagatcaaa ttcttggtgg aattgctgat 300actattgttg atagtacagt ccaagatatt ttagacaaaa tcacaacaga cccttctcta 360ggtttgttga aagcttttaa caactttcca atcactaata aaattcaatg caacgggtta 420ttcactccca ggaacattga aactttatta ggaggaactg aaataggaaa attcacagtc 480acacccaaaa gctctgggag catgttctta gtctcagcag atattattgc atcaagaatg 540gaaggcggcg ttgttctagc tttggtacga gaaggtgatt ctaagcccta cgcgattagt 600tatggatact catcaggcgt tcctaattta tgtagtctaa gaaccagaat tattaataca 660ggattgactc cgacaacgta ttcattacgt gtaggcggtt tagaaagcgg tgtggtatgg 720gttaatgccc tttctaatgg caatgatatt ttaggaataa caaatacttc taatgtatct 780tttttggagg taatacctca aacaaacgct taa 813<210>361<211>750<212>DNA<213>衣原体属<400>361atgcatcacc atcaccatca caaaataact ccgatcaaaa cacgtaaagt atttgcacat 60gattcgcttc aagagatctt gcaagaggct ttgccgcctc tgcaagaacg gagtgtggta 120gttgtctctt caaagattgt gagtttatgt gaaggcgctg tcgctgatgc aagaatgtgc 180aaagcagagt tgataaaaaa agaagcggat gcttatttgt tttgtgagaa aagcgggata 240tatctaacga aaaaagaagg tattttgatt ccttctgcag ggattgatga atcgaatacg 300gaccagcctt ttgttttata tcctaaagat attttgggat cgtgtaatcg catcggagaa 360tggttaagaa attattttcg agtgaaagag ctaggcgtaa tcattacaga tagccatact 420actccaatgc ggcgtggagt actgggtatc gggctgtgtt ggtatggatt ttctccatta 480cacaactata taggatcgct agattgtttc ggtcgtccct tacagatgac gcaaagtaat 540cttgtagatg ccttagcagt tgcggctgtt gtttgtatgg gagaggggaa tgagcaaaca 600ccgttagcgg tgatagagca ggcacctaat atggtctacc attcatatcc tacttctcga 660gaagagtatt gttctttgcg catagatgaa acagaggact tatacggacc ttttttgcaa 720gcggttacgt ggagtcaaga aaagaaatag 750<210>362<211>412<212>PRT<213>衣原体属<400>362Met His His His His His His Pro Pro Glu Ser Gly Leu Ile Ile Ala

5 10 15Ile His Asp Asp Pro Arg Ser Leu Ser Pro Glu Lys Gly Glu Asn Ala

20 25 30Phe His Phe Ser Leu Ser Lys Ala Leu Phe Ala Thr Leu Phe Arg Glu

35 40 45Glu Leu Ser Gly Leu Thr Pro Ala Leu Val Ser Ser Tyr Gln Val Ser

50 55 60Glu Asp Gly Arg Phe Tyr Arg Phe Cys Ile Arg Lys Asp Ala Lys Trp65 70 75 80Ser Asp Gly Ser Leu Leu Leu Ala Glu Asp Val Ile Ala Ala Trp Glu

85 90 95His Thr Lys Gln Ala Gly Arg Tyr Ser Leu Leu Phe Glu Lys Leu Ser

100 105 110Phe Arg Ala Ser Ser Ser Ser Glu Ile Leu Ile Glu Leu Lys Glu Pro

115 120 125Glu Pro Gln Leu Leu Ala Ile Leu Ala Ser Pro Phe Phe Ala Val Tyr

130 135 140Arg Pro Glu Asn Pro Phe Leu Ser Ser Gly Pro Phe Met Pro Lys Thr145 150 155 l60Tyr Val Gln Gly Gln Thr Leu Val Leu Gln Lys Asn Pro Tyr Tyr Tyr

165 170 175Asp His Ala His Val Glu Leu His Ser Ile Asp Phe Arg Ile Ile Pro

180 185 190Asn Ile Tyr Thr Ala Leu His Leu Leu Arg Arg Gly Asp Val Asp Trp

195 200 205Val Gly Gln Pro Trp His Gln Gly Ile Pro Phe Glu Leu Arg Thr Thr

210 215 220Ser Ala Leu Tyr Thr His Tyr Pro Val Asp Gly Thr Phe Trp Leu Ile225 230 235 240Leu Asn Pro Lys Asp Pro Val Leu Ser Ser Leu Ser Asn Arg Gln Arg

245 250 255Leu Ile Ala Ala Ile Gln Lys Glu Lys Leu Val Lys Gln Ala Leu Gly

260 265 270Thr Gln Tyr Arg Val Ala Glu Ser Ser Pro Ser Pro Glu Gly Ile Ile

275 280 285Ala His Gln Glu Ala Ser Thr Pro Phe Pro Gly Lys Ile Thr Leu Ile

290 295 300Tyr Pro Asn Asn Ile Thr Arg Cys Gln Arg Leu Ala Glu Val Leu Gln305 310 315 320Glu Gln Cys Arg Asp Ala Gly Ile Gln Leu Thr Leu Glu Gly Leu Glu

325 330 335Tyr His Val Phe Val Gln Lys Arg Ala Thr Gln Asp Phe Ser Val Ser

340 345 350Thr Ala Thr Ser Ile Ala Phe His Pro Leu Ala Lys Ser Lys Phe Asp

355 360 365Gln Thr Ala Leu Asp Asn Phe Thr Cys Leu Pro Leu Tyr His Ile Glu

370 375 380Tyr Asp Tyr Ile Leu Ser Arg Pro Leu Asp Gln Ile Val His Tyr Pro385 390 395 400Ser Gly Ser Val Asp Leu Thr Tyr Ala His Phe His

405 410<210>363<211>433<212>PRT<213>衣原体属<400>363Met His His His His His His Met Tyr Val Arg Ser Ile Phe Phe Ser

5 10 15Ile Ile Ala Phe Leu Thr Val Gly Cys Ser Phe Ser Pro Pro Glu Ser

20 25 30Gly Leu Ile Ile Ala Ile His Asp Asp Pro Arg Ser Leu Ser Pro Glu

35 40 45Lys Gly Glu Asn Ala Phe His Phe Ser Leu Ser Lys Ala Leu Phe Ala

50 55 60Thr Leu Phe Arg Glu Glu Leu Ser Gly Leu Thr Pro Ala Leu Val Ser65 70 75 80Ser Tyr Gln Val Ser Glu Asp Gly Arg Phe Tyr Arg Phe Cys Ile Arg

85 90 95Lys Asp Ala Lys Trp Ser Asp Gly Ser Leu Leu Leu Ala Glu Asp Val

100 105 110Ile Ala Ala Trp Glu His Thr Lys Gln Ala Gly Arg Tyr Ser Leu Leu

115 120 125Phe Glu Lys Leu Ser Phe Arg Ala Ser Ser Ser Ser Glu Ile Leu Ile

130 135 140Glu Leu Lys Glu Pro Glu Pro Gln Leu Leu Ala Ile Leu Ala Ser Pro145 150 155 160Phe Phe Ala Val Tyr Arg Pro Glu Asn Pro Phe Leu Ser Ser Gly Pro

165 170 175Phe Met Pro Lys Thr Tyr Val Gln Gly Gln Thr Leu Val Leu Gln Lys

180 185 190Asn Pro Tyr Tyr Tyr Asp His Ala His Val Glu Leu His Ser Ile Asp

195 200 205Phe Arg Ile Ile Pro Asn Ile Tyr Thr Ala Leu His Leu Leu Arg Arg

210 215 220Gly Asp Val Asp Trp Val Gly Gln Pro Trp His Gln Gly Ile Pro Phe225 230 235 240Glu Leu Arg Thr Thr Ser Ala Leu Tyr Thr His Tyr Pro Val Asp Gly

245 250 255Thr Phe Trp Leu Ile Leu Asn Pro Lys Asp Pro Val Leu Ser Ser Leu

260 265 270Ser Asn Arg Gln Arg Leu Ile Ala Ala Ile Gln Lys Glu Lys Leu Val

275 280 285Lys Gln Ala Leu Gly Thr Gln Tyr Arg Val Ala Glu Ser Ser Pro Ser

290 295 300Pro Glu Gly Ile Ile Ala His Gln Glu Ala Ser Thr Pro Phe Pro Gly305 310 315 320Lys Ile Thr Leu Ile Tyr Pro Asn Asn Ile Thr Arg Cys Gln Arg Leu

325 330 335Ala Glu Val Leu Gln Glu Gln Cys Arg Asp Ala Gly Ile Gln Leu Thr

340 345 350Leu Glu Gly Leu Glu Tyr His Val Phe Val Gln Lys Arg Ala Thr Gln

355 360 365Asp Phe Ser Val Ser Thr Ala Thr Ser Ile Ala Phe His Pro Leu Ala

370 375 380Lys Ser Lys Phe Asp Gln Thr Ala Leu Asp Asn Phe Thr Cys Leu Pro385 390 395 400Leu Tyr His Ile Glu Tyr Asp Tyr Ile Leu Ser Arg Pro Leu Asp Gln

405 410 415Ile Val His Tyr Pro Ser Gly Ser Val Asp Leu Thr Tyr Ala His Phe

420 425 430His<210>364<211>264<212>PRT<213>衣原体属<400>364Met Gly Asn Ser Gly Phe Tyr Leu Tyr Asn Thr Gln Asn Cys Val Phe

5 10 15Ala Asp Asn Ile Lys Val Gly Gln Met Thr Glu Pro Leu Lys Asp Gln

20 25 30Gln Ile Ile Leu Gly Thr Thr Ser Thr Pro Val Ala Ala Lys Met Thr

35 40 45Ala Ser Asp Gly Ile Ser Leu Thr Val Ser Asn Asn Pro Ser Thr Asn

50 55 60Ala Ser Ile Thr Ile Gly Leu Asp Ala Glu Lys Ala Tyr Gln Leu Ile65 70 75 80Leu Glu Lys Leu Gly Asp Gln Ile Leu Gly Gly Ile Ala Asp Thr Ile

85 90 95Val Asp Ser Thr Val Gln Asp Ile Leu Asp Lys Ile Thr Thr Asp Pro

100 105 110Ser Leu Gly Leu Leu Lys Ala Phe Asn Asn Phe Pro Ile Thr Asn Lys

115 120 125Ile Gln Cys Asn Gly Leu Phe Thr Pro Arg Asn Ile Glu Thr Leu Leu

130 135 140Gly Gly Thr Glu Ile Gly Lys Phe Thr Val Thr Pro Lys Ser Ser Gly145 150 155 160Ser Met Phe Leu Val Ser Ala Asp Ile Ile Ala Ser Arg Met Glu Gly

165 170 175Gly Val Val Leu Ala Leu Val Arg Glu Gly Asp Ser Lys Pro Tyr Ala

180 185 190Ile Ser Tyr Gly Tyr Ser Ser Gly Val Pro Asn Leu Cys Ser Leu Arg

195 200 205Thr Arg Ile Ile Asn Thr Gly Leu Thr Pro Thr Thr Tyr Ser Leu Arg

210 215 220Val Gly Gly Leu Glu Ser Gly Val Val Trp Val Asn Ala Leu Ser Asn225 230 235 240Gly Asn Asp Ile Leu Gly Ile Thr Asn Thr Ser Asn Val Ser Phe Leu

245 250 255Glu Val Ile Pro Gln Thr Asn Ala

260<210>365<211>249<212>PRT<213>衣原体属<400>365Met His His His His His His Lys Ile Thr Pro Ile Lys Thr Arg Lys

5 10 15Val Phe Ala His Asp Ser Leu Gln Glu Ile Leu Gln Glu Ala Leu Pro

20 25 30Pro Leu Gln Glu Arg Ser Val Val Val Val Ser Ser Lys Ile Val Ser

35 40 45Leu Cys Glu Gly Ala Val Ala Asp Ala Arg Met Cys Lys Ala Glu Leu

50 55 60Ile Lys Lys Glu Ala Asp Ala Tyr Leu Phe Cys Glu Lys Ser Gly Ile65 70 75 80Tyr Leu Thr Lys Lys Glu Gly Ile Leu Ile Pro Ser Ala Gly Ile Asp

85 90 95Glu Ser Asn Thr Asp Gln Pro Phe Val Leu Tyr Pro Lys Asp Ile Leu

100 105 110Gly Ser Cys Asn Arg Ile Gly Glu Trp Leu Arg Asn Tyr Phe Arg Val

115 120 125Lys Glu Leu Gly Val Ile Ile Thr Asp Ser His Thr Thr Pro Met Arg

130 135 140Arg Gly Val Leu Gly Ile Gly Leu Cys Trp Tyr Gly Phe Ser Pro Leu145 150 155 160His Asn Tyr Ile Gly Ser Leu Asp Cys Phe Gly Arg Pro Leu Gln Met

165 170 175Thr Gln Ser Asn Leu Val Asp Ala Leu Ala Val Ala Ala Val Val Cys

180 185 190Met Gly Glu Gly Asn Glu Gln Thr Pro Leu Ala Val Ile Glu Gln Ala

195 200 205Pro Asn Met Val Tyr His Ser Tyr Pro Thr Ser Arg Glu Glu Tyr Cys

210 215 220Ser Leu Arg Ile Asp Glu Thr Glu Asp Leu Tyr Gly Pro Phe Leu Gln225 230 235 240Ala Val Thr Trp Ser Gln Glu Lys Lys

245<210>366<211>2418<212>DNA<213>肺炎衣原体<400>366atggacccaa aagaaaaaaa ttacgatgca tccgctatta ctgttttaga agggctacaa 60gctgttcgtg agcgccccgg gatgtacatt ggagatacgg gaatcacggg tcttcatcat 120ctagtctatg aggttgtaga caacagcatt gacgaagcca tggcaggtta ttgctctagg 180attgatgttc gcattttaga ggacgggggt attgtcatcg tagataatgg ccgaggaatc 240cctatagaag ttcacgaaag agagtctgca aaacaaggta gagaggtctc tgctttagaa 300gtggttttaa cagtccttca tgctggagga aaattcgata aggatagcta taaagtatcc 360ggaggcttgc acggagttgg ggtttcttgc gttaatgctc tttcggagaa attagttgcc 420acggtcttta aagataagaa gtgttatcaa atggagttct ctaggggaat tcctgtaact 480ccattgcagt atgtaagtgt tagtgatcgg cagggaacag aaatcgtttt ctaccctgat 540cctaaaatat tttcgacttg tacttttgat cgctctattt taatgaaacg cttgcgagag 600cttgctttct taaatcgtgg gatcacaata gtctttgaag atgatcgaga tgttagcttt 660gacaaggtta ccttctttta tgagggaggg attcaatctt ttgtaagtta cctgaatcaa 720aataaagaaa gccttttctc tgaaccgatt tatatttgtg gaactcgagt aggagatgat 780ggagaaatcg agtttgaagc agccttacaa tggaattcag ggtattctga acttgtttat 840tcctatgcca ataatattcc tacacgccaa ggaggaacgc atcttacagg gttttctacc 900gcgcttacta gggtaatcaa tacgtatatt aaagctcata accttgcgaa gaataataag 960cttgcattaa ccggagaaga tattcgagaa ggtctgacag ctgtgatttc tgtaaaggtc 1020ccaaatccac aatttgaagg gcaaacaaaa cagaaattag gaaacagtga tgttagctca 1080gtggctcaac aggttgtagg ggaagctctg acaatctttt ttgaagagaa tcctcaaatt 1140gctaggatga ttgttgataa ggtttttgtt gcagcgcaag ctagagaagc tgcaaaaaaa 1200gctcgagaat tgactttaag gaaaagtgct ttagatagcg cacgcttacc tggaaaacta 1260attgattgtt tagaaaaaga tcccgaaaag tgtgagatgt acattgtgga gggggattct 1320gctggaggat ctgcgaaaca aggtagagat cgaagatttc aagcaattct gcctattcga 1380ggtaaaattc tgaacgtaga aaaagctcgt ctacagaaaa ttttccaaaa ccaagagata 1440ggaaccatca tagcagcttt aggctgtggc ataggtgctg ataattttaa tctcagtaaa 1500ttacgctata gacgtatcat tatcatgaca gatgctgacg tggacggttc tcatattcgt 1560accctacttc tcacattctt ctatcgtcat atgacagcgc ttattgaaaa tgaatgtgtt 1620tatattgctc aacctccttt atacaaggtg agtaagaaaa aagacttccg ttatattctt 1680tcagagaaag aaatggacag ctatttgctc atgttaggca cgaatgagag ctccattctc 1740tttaaatcta cggaaagaga attacgtgga gaggctttag agagttttat caacgtcatt 1800ttagatgtag agagctttat aaacactctt gagaaaaaag cgattccctt ctctgaattt 1860ttagagatgt ataaagaggg gataggctat cctttgtact atcttgctcc ggcaactgga 1920atgcagggag ggcgctatct ttattctgat gaggaaaaag aagaagcttt agctcaagaa 1980gaaactcata agtttaaaat catagagctt tataaagttg ctgtgttcgt agatattcaa 2040aatcaactca aagaatatgg tttagatatt tctagctatc ttatccctca gaaaaacgag 2100attgtgattg gaaatgaaga ttccccaagc tgtaactata gctgctatac cttggaagaa 2160gtcattaact atcttaaaaa tcttggaaga aaaggcatag aaattcagag gtataaaggt 2220cttggagaga tgaatgccga ccagctttgg gatactacta tgaatcctga gcagagaaca 2280ctcattcatg tgtcattgaa ggatgccgta gaagcagacc atattttcac tatgttgatg 2340ggggaagaag tccctccaag aagagaattc atagaaagtc atgctttgtc cattaggata 2400aataatttag atatttag 2418<210>367<211>888<212>DNA<213>肺炎衣原体<400>367atggaaaagt tactagtgac tgatattgac ggtacaatta cccatcaatc tcatcattta 60gataaaaagg tgtatgagcg gctctatgcg ctgcaccaag ctggttggaa gttgtttttc 120ttgacgggaa ggtattataa atatgctgca cgcttgtttt ctgattttga tgctccatat 180ttattaggat gccaaaacgg cgcttctgta tggtcttcaa catcatcaaa tcttctctat 240tctaaaagtt taccctcaga tttattatgt attttacaag attgtatgga gggggcaacg 300gctctttttt ccgtggaatc aggagctcct tacggggatc actactatcg cttttcaccg 360actcctatag ctcaagattt acacgaatat gtagatccta ggtactttcc taatgctaag 420gaaagagaga tcctatttga aacgcgctct ttaaaagacg actatgcttt tcctagtttt 480gctgcagcaa aagtctttgg actgcgagat gaggtcatca gaattcaaaa ggagctggaa 540cgccaagaag cactgacttc agtcgcgacg atgacgttaa tgcgctggcc ctttgacttt 600cgctatgcca tcttgttttt aacagataaa agcgtctcta aaggcaaagc cttagatcgt 660gttgtcaata tactttatga tggaaagaaa ccctttgtca tggcttcagg agatgatgct 720aatgatctcg atcttattga gagaggagat tttaaaattg tgatgagttc cgcacctgaa 780gagatgcacg ttcatgcgga ctttctagct cccccagcag ataagaatgg cattctttca 840gcttgggaag ctggtgtccg ctattatgac gaccttatga gtctttag 888<210>368<211>237<212>DNA<213>肺炎衣原体<400>368atgaaagaat ttttagccta tatcattaag aatctagtgg accgccctga agaagtccgt 60attaaagaag ttcaggggac tcacacgatt atttatgaac taagtgtagc taaacctgat 120atcgggaaga tcattggcaa agaaggccgt acgatcaaag cgattcgtac tcttctggtt 180tctgtagcaa gcaggaacaa tgtaagggtc agtttagaaa ttatggaaga aaagtag 237<210>369<211>1437<212>DNA<213>肺炎衣原体<400>369atgcgtgacg tttcagagct ttttcgaaca cattttatgc attacgcgtc ttacgtaatt 60ttagagagag cgattcctca tattcttgat ggcttaaaac cggtgcagcg tcgacttcta 120tggactttat tccttatgga cgacgggaaa atgcataaag ttgccaatat tgcaggaaga 180actatggctc tccatcccca tggcgatgcc cctattgttg aagctcttgt tgtcttagca 240aataaaggct acctcatcga cacgcaagga aacttcggaa atccccttac gggagatcct 300cacgctgctg cccgttatat agaagcacga ctcagtcctt tagctcgaga aacgctcttt 360aataccgact tgatagcttt tcatgactct tatgatggaa gagaaaaaga acctgatatt 420ttacctgcaa agctccccgt gcttttactt catggtgtgg acgggattgc tgtggggatg 480accacgaaaa ttttccctca caattttgca gaacttttga aagcgcaaat tgcaatttta 540aatgataaaa aattcactgt gtttcctgac tttccttcgg gaggattgat ggatccctcg 600gagtatcaag atggattggg atcgattaca ctgcgtgcat ctatagacat tattaatgat 660aaaacgcttg tagtgaaaca aatttgtcct caatctacga ctgagacttt gatccgttct 720atagagaacg cagcaaaacg tggcacaatt aaaatcgata ccatccaaga cttctctaca 780gatgtccctc acattgaaat taagctgcca aaaggctctc gagccaaaga gatgcttccc 840ttgttattcg agcatactga atgccaggtg attctctatt ctaagcccac agtcatttac 900gagaataagc ctgtagaatg ttcgatatcc gagattctca aactgcatac tacagctcta 960caggggtatc ttgaaaaaga acttttgttg ctccaagaac aacttacttt ggaccattat 1020cataaaacct tagaatacat ctttattaaa cataagctct atgattctgt ccgagaagtc 1080ctagccataa acaagaaaat ttctgctgat gacctacatc aagcagtgct ccatgctctg 1140gagccctggc ttcatgagct tgcaactccc gttacaaaac aagacacctc tcaacttgct 1200tcactaacga ttaagaaaat cctttgcttt aatgaagagg catgcactaa ggaactgcta 1260gccatagaaa aaaaacaagc agcgatacaa aaagatcttg gaagaataaa agaagtcacc 1320gtcaagtacc tcaaaggact tttagaacgc catggacact taggagagag aaaaacacag 1380atcacaaact ttaagacggc aaagacatct atcttgaaac aacaaacctt aatttaa 1437<210>370<211>774<212>DNA<213>肺炎衣原体<400>370atggcatttt attctccttc aacgatctct aaatatttta tctattctgg agcaggaaat 60cgtttccttc ttggtgaaac acttcctgag gttgaagatg ttcggttctt atgccaagag 120acgagggttg atggtttttt atatttaaag ccctcttctt gtgctgatgc gcaactcatt 180atttttaatt ccgatggatc acgtccaacg atgtgtggta acggcttgcg ttgtgcgatt 240gctcacttag cttctcagaa gggaaaatcg gacatctctg tatctacgga tagtggtcta 300tattcaggat atttttattc ttgggatcgt gtgcttgtag atatgactct cgcagattgg 360agagcttctg ttcatcgatt ggagtcgcgt cctgatcctc ttcccaaaga ggtcgtttgt 420atccatacgg gagtgcctca tgctgtcgta attcttcctg agatttctac tttagatctt 480tctatcttag gtccttttct tcgctatcat cagaccttct ctccagatgg ggtgaatgtc 540aattttgttc agatactggg acattgccag ttgcgcgttc gtacttacga acgtggagtc 600gaaggggaaa ctgcagcttg tggaacaggg gctctagctt ctgctcttgt tgtgtcaaac 660tcctatggat ggaaggagtc gatccaaatc catacttggg gtggagagct tatgactgtg 720agtcaaaata ggggacgggt atatcttcag ggctctgtaa ctagagattt ataa 774<210>371<211>576<212>DNA<213>肺炎衣原体<400>371atggcagacg gggaagttca taaattacgt gatattatag aaaaagagtt attggaagcg 60cgcagagtat ttttctcaga gcctgtaaca gagaaaagtg cttccgatgc aattaaaaag 120ctttggtatt tggaattaaa agatcctgga aagcctatag tttttgtgat caatagtcct 180gggggatctg tggacgcagg ttttgctgtt tgggatcaaa ttaaaatgtt aacctcaccc 240gtcactactg ttgtgacagg gttggcagct tctatgggct cggtattgag tttatgtgca 300gctcctggaa ggagatttgc aactcctcat tctagaatta tgattcatca accttcaata 360ggtggaccga ttaccggtca ggcaaccgat ttagacattc atgcgagaga gattttaaaa 420acaaaagctc gcattataga tgtctatgta gaggcgacaa atcaacctcg agatatcata 480gaaaaggcta tcgatagaga tatgtggatg acagccaacg aagctaagga ttttggttta 540ttcgatggca ttttattctc cttcaacgat ctctaa 576<210>372<211>699<212>DNA<213>肺炎衣原体<400>372atgacaaaac atggaaaacg tatacgaggc atcttaaaga actatgattt ctcaaaatca 60tattctttgc gggaggctat agatatttta aaacaatgtc ctccagtacg cttcgatcaa 120actgtagatg tatctatcaa gttagggata gatcctaaaa agagcgacca acaaattcgt 180ggagccgttt ttttacctaa tggtacagga aaaactttaa gaattttggt ttttgcttca 240gggaacaaag tcaaagaagc tgttgaagcg ggcgcagact ttatgggaag cgacgatctt 300gttgaaaaaa ttaaatccgg gtggctggaa ttcgatgttg ctgtcgctac cccagatatg 360atgcgtgaag taggaaaatt aggaaaagtc ttaggaccta gaaatctaat gcctacacct 420aaaacaggaa cggtaaccac agacgttgct aaagcaatct ccgaattgcg taaaggaaaa 480attgaattta aagcagaccg cgcaggcgta tgtaatgtag gcgtaggtaa gttgtctttt 540gaaagcagtc aaatcaaaga aaatattgaa gctctaagtt ctgctttaat taaggccaaa 600cctcctgcag ctaaaggtca atatttagtc tcattcacta tttcttccac tatggggcct 660ggtatttcta tagatactag agaattaatg gcatcttaa 699<210>373<211>369<212>DNA<213>肺炎衣原体<400>373atgccacgca tcattggaat tgatattcct gcaaagaaaa agttaaaaat aagtctgaca 60tatatttatg gaataggatc agctcgttct gatgaaatca ttaaaaagtt gaagttagat 120cctgaggcaa gagcctctga attaactgaa gaagaagtag gacgactgaa ctctctgcta 180caatcagaat ataccgtaga aggggatttg cgacgtcgtg ttcaatcgga tatcaaaaga 240ttgatcgcca tccattctta tcgaggtcag agacatagac tttctttacc agtaagagga 300caacgtacaa aaactaattc tcgtactcga aaaggtaaaa gaaaaacagt cgcaggtaag 360aagaaataa 369<210>374<211>5172<212>DNA<213>肺炎衣原体<400>374atgaagtggc taccagctac agctgttttt gctgccgtac tccccgcact aacagccttc 60ggagatcccg cgtctgttga aataagtacc agccatacag gatccgggga tcctacaagc 120gacgctgcct taacaggatt tacacaaagt tccacagaaa ctgacggtac tacctatacc 180attgtcggtg atatcacctt ctctactttt acgaatattc ctgttcccgt agtaactcca 240gacgccaacg atagttccag caatagctct aaaggaggaa gtagcagtag tggagctaca 300tctctaatcc gatcctcaaa cctacactcc gattttgatt ttacaaaaga tagcgtgtta 360gacctctatc accttttctt tccttcagct tcaaatactc tcaatcctgc actcctttct 420tccagtagca gcggtggatc ctcgagcagc agtagctcct catcatctgg aagtgcatct 480gctgttgttg ctgcggaccc aaaaggaggc gctgcctttt atagtaacga ggctaacgga 540actttaacct tcactacaga ctctggaaat cccggctccc tgactcttca gaatcttaaa 600atgaccggag atggagccgc catctactcg aagggtcctc tagtatttac tggtttaaaa 660aatctaacct ttacaggaaa tgaatctcag aaatctggag gtgctgccta tactgaaggc 720gcactcacaa cacaagcaat cgttgaagcc gtaactttta ctggcaacac ctcggcaggg 780caaggaggcg ctatctatgt taaagaagct accctattca atgctctaga cagcctcaaa 840tttgaaaaaa acacttctgg gcaagctggt ggtggaatct atacagagtc tacgctcaca 900atctcgaaca tcacaaaatc tattgaattt atctctaata aagcttctgt ccctgccccc 960gctcctgagc ccacctctcc ggctccaagt agcttaataa attctacaac gatcgatacc 1020tcgactctcc aaacccgagc agcatccgca actccagcag tggctcctgt tgctgccgta 1080actccaacac caatctctac tcaagagacc gcaggaaatg gaggcgctat ctatgctaaa 1140caaggtattt cgatatccac gtttaaagat ctgaccttca agtctaactc tgcatcggta 1200gatgccaccc ttactgtcga ttctagcact attggagaat ctggaggtgc tatctttgca 1260gcagactcta tacaaatcca acagtgcacg ggaaccacct tattcagtgg caatactgcc 1320aataagtctg gtgggggtat ttacgctgta ggacaagtca ccctagaaga tatagcgaat 1380ctgaagatga ccaacaacac ctgtaaaggt gaaggtggag ccatctacac taaaaaggct 1440ttaactatca acaacggtgc cattctcact acattttctg gaaatacatc gacagataat 1500ggtggggcta tttttgctgt aggtggcatc actctctctg atcttgtaga agtccgcttt 1560agtaaaaata agaccggaaa ttattccgct cctattacca aagcggctag caacacagct 1620cctgtagttt ctagctctac aactgctgca tctcctgcgg tccctgctgc cgctgcagca 1680cctgttacaa acgcagcaaa aggaggggct ttatatagta cagaaggact gactgtatct 1740ggaatcacat cgatattgtc gtttgaaaac aacgaatgcc agaatcaagg aggtggggct 1800tacgttacta aaaccttcca gtgttccgat tctcatcgcc tccagtttac tagtaataaa 1860gcagcagatg aaggcggggg cctgtattgt ggtgacgatg tcacgctaac gaacctgaca 1920gggaaaacac tatttcaaga gaatagcagt gagaaacatg gaggtgggct ctctctcgcc 1980tcaggaaaat ctctgactat gacatcgtta gagagcttct gcttaaatgc aaatacagca 2040aaggaaaacg gaggcggtgc gaatgtccct gaaaatattg tactcacctt cacctatact 2100cccactccaa atgaacctgc gcctgtgcag cagcccgtgt atggagaagc tcttgttact 2160ggaaatacag ccacaaaaag tggtgggggc atttacacga aaaatgcggc cttctcaaat 2220ttatcttctg taacttttga tcaaaatacc tcttcagaaa atggtggtgc cttacttacc 2280caaaaagctg cagataaaac ggactgttct ttcacctata ttacaaatgt caatatcacc 2340aacaatacag ctacaggaaa tggtgggggc attgctgggg gaaaagcaca tttcgatcgc 2400attgataatc ttacagtcca aagcaaccaa gcaaagaaag gtggtggggt ttatcttgaa 2460gatgccctca tcctggaaaa ggttattaca ggttctgtct cacaaaatac agctacagaa 2520agtggtgggg gtatctacgc taaggatatt caactacaag ctctacctgg aagcttcaca 2580attaccgata ataaagtcga aactagtctt actactagca ctaatttata tggtgggggc 2640atctattcca gtggagctgt cacgctaacc aatatatctg gaacctttgg cattacagga 2700aactctgtta tcaatacagc gacatcccag gatgcagata tacaaggtgg gggcatttat 2760gcaaccacgt ctctctcaat aaatcaatgt aatacaccca ttctatttag caacaactct 2820gctgccacta aaaaaacatc aacaacaaag caaattgctg gtggggctat cttctccgct 2880gcagtaacta tcgagaataa ctctcagccc attattttct taaataattc cgcaaagtcg 2940gaagcaacta cagcagcaac tgcaggaaat aaagatagct gtggaggagc cattgcagct 3000aactctgtta ctttaacaaa taaccctgaa ataaccttta aaggaaatta tgcagaaact 3060ggaggagcga ttggctgtat tgatcttact aatggctcac ctccccgtaa agtctctatt 3120gcagacaacg gttctgtcct ttttcaagac aactctgcgt taaatcgcgg aggcgctatc 3180tatggagaga ctatcgatat ctccaggaca ggtgcgactt tcatcggtaa ctcttcaaaa 3240catgatggaa gtgcaatttg ctgttcaaca gccctaactc ttgcgccaaa ctcccaactt 3300atctttgaaa acaataaggt tacggaaacc acagccacta caaaagcttc cataaataat 3360ttaggagctg caatttatgg aaataatgag actagtgacg tcactatctc tttatcagct 3420gagaatggaa gtattttctt taaaaacaat ctatgcacag caacaaacaa atactgcagt 3480attgctggaa acgtaaaatt tacagcaata gaagcttcag cagggaaagc tatatctttc 3540tatgatgcag ttaacgtttc caccaaagaa acaaatgctc aagagctaaa attaaatgaa 3600aaagcgacaa gtacaggaac gattctattt tctggggaac ttcacgaaaa taaatcctat 3660attccacaga aagtcacttt cgcacatggg aatctcattc taggtaaaaa tgcagaactt 3720agcgtagttt cctttaccca atctccaggc accacaatca ctatgggccc aggatcggtt 3780ctttccaacc atagcaaaga agcaggagga atcgctataa acaatgtcat cattgatttt 3840agtgaaatcg ttcctactaa agataatgca acagtagctc cacccactct taaattagta 3900tcgagaacta atgcagatag taaagataag attgatatta caggaactgt gactcttcta 3960gatcctaatg gcaacttata tcaaaattct tatcttggtg aagaccgcga tatcactctt 4020ttcaatatag acaattctgc aagtggggca gttacagcca cgaatgtcac ccttcaaggg 4080aatttaggag ctaaaaaagg atatttagga acctggaatt tggatccaaa ttcctcgggt 4140tcaaaaatta ttctaaaatg gacctttgac aaatacctgc cctggcccta catccctaga 4200gacaaccact tctacatcaa ctctatttgg ggagcacaaa actctttagt gactgtgaaa 4260caagggatct tagggaacat gttgaacaat gcaaggtttg aagatcctgc tttcaacaac 4320ttctgggctt cggctatagg atctttcctt aggaaagaag tatctcgaaa ttctgactca 4380ttcacctatc atggcagagg ctataccgct gctgtggatg ccaaacctcg ccaagaattt 4440attttaggag ctgccttcag tcaggttttt ggtcacgccg agtctgaata tcaccttgac 4500aactataagc ataaaggctc aggtcactct acacaagcat ctctttatgc tggcaatatc 4560ttctattttc ctgcgatacg gtctcggcct attctattcc aaggtgtggc gacctatggt 4620tatatgcaac atgacaccac aacctactat ccttctattg aagaaaaaaa tatggcaaac 4680tgggatagca ttgcttggtt atttgatctg cgtttcagtg tggatcttaa agaacctcaa 4740cctcactcta cagcaaggct taccttctat acagaagctg agtataccag aattcgccag 4800gagaaattca cagagctaga ctatgatcct agatctttct ctgcatgctc ttatggaaac 4860ttagcaattc ctactggatt ctctgtagac ggagcattag cttggcgtga gattattcta 4920tataataaag tatcagctgc gtacctccct gtgattctca ggaataatcc aaaagcgacc 4980tatgaagttc tctctacaaa agaaaagggc aacgtagtca acgttctccc tacaagaaac 5040gcagctcgtg cagaggtgag ctctcaaatt tatcttggaa gttactggac actctacggc 5100acgtatacta ttgatgcttc aatgaatact ttagtgcaaa tggccaacgg agggatccgg 5160tttgtattct ag 5172<210>375<211>5172<212>DNA<213>肺炎衣原体<400>375atgaagtggc taccagctac agctgttttt gctgccgtac tccccgcact aacagccttc 60ggagatcccg cgtctgttga aataagtacc agccatacag gatccgggga tcctacaagc 120gacgctgcct taacaggatt tacacaaagt tccacagaaa ctgacggtac tacctatacc 180attgtcggtg atatcacctt ctctactttt acgaatattc ctgttcccgt agtaactcca 240gacgccaacg atagttccag caatagctct aaaggaggaa gtagcagtag tggagctaca 300tctctaatcc gatcctcaaa cctacactcc gattttgatt ttacaaaaga tagcgtgtta 360gacctctatc accttttctt tccttcagct tcaaatactc tcaatcctgc actcctttct 420tccagtagca gcggtggatc ctcgagcagc agtagctcct catcatctgg aagtgcatct 480gctgttgttg ctgcggaccc aaaaggaggc gctgcctttt atagtaacga ggctaacgga 540actttaacct tcactacaga ctctggaaat cccggctccc tgactcttca gaatcttaaa 600atgaccggag atggagccgc catctactcg aagggtcctc tagtatttac tggtttaaaa 660aatctaacct ttacaggaaa tgaatctcag aaatctggag gtgctgccta tactgaaggc 720gcactcacaa cacaagcaat cgttgaagcc gtaactttta ctggcaacac ctcggcaggg 780caaggaggcg ctatctatgt taaagaagct accctattca atgctctaga cagcctcaaa 840tttgaaaaaa acacttctgg gcaagctggt ggtggaatct atacagagtc tacgctcaca 900atctcgaaca tcacaaaatc tattgaattt atctctaata aagcttctgt ccctgccccc 960gctcctgagc ccacctctcc ggctccaagt agcttaataa attctacaac gatcgatacc 1020tcgactctcc aaacccgagc agcatccgca actccagcag tggctcctgt tgctgccgta 1080actccaacac caatctctac tcaagagacc gcaggaaatg gaggcgctat ctatgctaaa 1140caaggtattt cgatatccac gtttaaagat ctgaccttca agtctaactc tgcatcggta 1200gatgccaccc ttactgtcga ttctagcact attggagaat ctggaggtgc tatctttgca 1260gcagactcta tacaaatcca acagtgcacg ggaaccacct tattcagtgg caatactgcc 1320aataagtctg gtgggggtat ttacgctgta ggacaagtca ccctagaaga tatagcgaat 1380ctgaagatga ccaacaacac ctgtaaaggt gaaggtggag ccatctacac taaaaaggct 1440ttaactatca acaacggtgc cattctcact acattttctg gaaatacatc gacagataat 1500ggtggggcta tttttgctgt aggtggcatc actctctctg atcttgtaga agtccgcttt 1560agtaaaaata agaccggaaa ttattccgct cctattacca aagcggctag caacacagct 1620cctgtagttt ctagctctac aactgctgca tctcctgcgg tccctgctgc cgctgcagca 1680cctgttacaa acgcagcaaa aggaggggct ttatatagta cagaaggact gactgtatct 1740ggaatcacat cgatattgtc gtttgaaaac aacgaatgcc agaatcaagg aggtggggct 1800tacgttacta aaaccttcca gtgttccgat tctcatcgcc tccagtttac tagtaataaa 1860gcagcagatg aaggcggggg cctgtattgt ggtgacgatg tcacgctaac gaacctgaca 1920gggaaaacac tatttcaaga gaatagcagt gagaaacatg gaggtgggct ctctctcgcc 1980tcaggaaaat ctctgactat gacatcgtta gagagcttct gcttaaatgc aaatacagca 2040aaggaaaacg gaggcggtgc gaatgtccct gaaaatattg tactcacctt cacctatact 2100cccactccaa atgaacctgc gcctgtgcag cagcccgtgt atggagaagc tcttgttact 2160ggaaatacag ccacaaaaag tggtgggggc atttacacga aaaatgcggc cttctcaaat 2220ttatcttctg taacttttga tcaaaatacc tcttcagaaa atggtggtgc cttacttacc 2280caaaaagctg cagataaaac ggactgttct ttcacctata ttacaaatgt caatatcacc 2340aacaatacag ctacaggaaa tggtgggggc attgctgggg gaaaagcaca ttttgatcgc 2400attgataatc ttacagtcca aagcaaccaa gcaaagaaag gtggtggggt ttatcttgaa 2460gatgccctca tcctggaaaa ggttattaca ggttctgtct cacaaaatac agctacagaa 2520agtggtgggg gtatctacgc taaggatatt caactacaag ctctacctgg aagcttcaca 2580attaccgata ataaagtcga aactagtctt actactagca ctaatttata tggtgggggc 2640atctattcca gtggagctgt cacgctaacc aatatatctg gaacctttgg cattacagga 2700aactctgtta tcaatacagc gacatcccag gatgcagata tacaaggtgg gggcatttat 2760gcaaccacgt ctctctcaat aaatcaatgt aatacaccca ttctatttag caacaactct 2820gctgccacta aaaaaacatc aacaacaaag caaattgctg gtggggctat cttctccgct 2880gcagtaacta tcgagaataa ctctcagccc attattttct taaataattc cgcaaagtcg 2940gaagcaacta cagcagcaac tgcaggaaat aaagatagct gtggaggagc cattgcagct 3000aactctgtta ctttaacaaa taaccctgaa ataaccttta aaggaaatta tgcagaaact 3060ggaggagcga ttggctgtat tgatcttact aatggctcac ctccccgtaa agtctctatt 3120gcagacaacg gttctgtcct ttttcaagac aactctgcgt taaatcgcgg aggcgctatc 3180tatggagaga ctatcgatat ctccaggaca ggtgcgactt tcatcggtaa ctcttcaaaa 3240catgatggaa gtgcaatttg ctgttcaaca gccctaactc ttgcgccaaa ctcccaactt 3300atctttgaaa acaataaggt tacggaaacc acagccacta caaaagcttc cataaataat 3360ttaggagctg caatttatgg aaataatgag actagtgaca tcactatctc tttatcagct 3420gagaatggaa gtattttctt taaaaacaat ctatgcacag caacaaacaa atactgcagt 3480attgctggaa acgtaaaatt tacagcaata gaagcttcag cagggaaagc tatatctttc 3540tatgatgcag ttaacgtttc caccaaagaa acaaatgctc aagagctaaa attaaatgaa 3600aaagcgacaa gtacaggaac gattctattt tctggggaac ttcacgaaaa taaatcctat 3660attccacaga aagtcacttt cgcacatggg aatctcattc taggtaaaaa tgcagaactt 3720agcgtagttt cctttaccca atctccaggc accacaatca ctatgggccc aggatcggtt 3780ctttccaacc atagcaaaga agcaggagga atcgctataa acaatgtcat cattgatttt 3840agtgaaatcg ttcctactaa agataatgca acagtagctc cacccactct taaattagta 3900tcgagaacta atgcagatag taaagataag attgatatta caggaactgt gactcttcta 3960gatcctaatg gcaacttata tcaaaattct tatcttggtg aagaccgcga tatcactctt 4020ttcaatatag acaattctgc aagtggggca gttacagcca cgaatgtcac ccttcaaggg 4080aatttaggag ctaaaaaagg atatttagga acctggaatt tggatccaaa ttcctcgggt 4140tcaaaaatta ttctaaaatg gacctttgac aaatacctgc gctggcccta catccctaga 4200gacaaccact tctacatcaa ctctatttgg ggagcacaaa actctttagt gactgtgaaa 4260caagggatct tagggaacat gttgaacaat gcaaggtttg aagatcctgc tttcaacaac 4320ttctgggctt cggctatagg atctttcctt aggaaagaag tatctcgaaa ttctgactca 4380ttcacctatc atggcagagg ctataccgct gctgtggatg ccaaacctcg ccaagaattt 4440attttaggag ctgccttcag tcaggttttt ggtcacgccg agtctgaata tcaccttgac 4500aactataagc ataaaggctc aggtcactct acacaagcat ctctttatgc tggcaatatc 4560ttctattttc ctgcgatacg gtctcggcct attctattcc aaggtgtggc gacctatggt 4620tatatgcaac atgacaccac aacctactat ccttctattg aagaaaaaaa tatggcaaac 4680tgggatagca ttgcttggtt atttgatctg cgtttcagtg tggatcttaa agaacctcaa 4740cctcactcta cagcaaggct taccttctat acagaagctg agtataccag aattcgccag 4800gagaaattca cagagctaga ctatgatcct agatctttct ctgcatgctc ttatggaaac 4860ttagcaattc ctactggatt ctctgtagac ggagcattag cttggcgtga gattattcta 4920tataataaag tatcagctgc gtacctccct gtgattctca ggaataatcc aaaagcgacc 4980tatgaagttc tctctacaaa agaaaagggc aacgtagtca acgttctccc tacaagaaac 5040gcagctcgtg cagaggtgag ctctcaaatt tatcttggaa gttactggac actctacggc 5100acgtatacta ttgatgcttc aatgaatact ttagtgcaaa tggccaacgg agggatccgg 5160tttgtattct ag 5172<210>376<211>3759<212>DNA<213>肺炎衣原体<400>376atgttgaagt gccctgaacg ggtcagtgtt aaaaaaaagg aagatatccc agaccttcca 60aatcttatcg aaatccaaat taagtcttat aagcagtttc ttcaaattgg aaaattagca 120gaagaaagag aaaatatcgg tttagaagag gttttcaggg aaatttttcc cattaaatcc 180tataacgaag ctaccgttct tgagtacctt tcatataatt tgggtgtgcc aaaatattct 240ccagaagaat gtatccgtag aggaattacc tatagcgtca ctttgaaagt ccgttttcgt 300ttaaccgatg aaacgggaat caaagaagaa gaagtctata tgggaacgat ccctctaatg 360actgataaag ggacatttat cattaatgga gctgaaagag tcgttgtttc ccaagttcat 420cgttctccag gaattaactt tgaacaagaa aaacattcca aaggtaatat tttattctcc 480ttcagaatca ttccttatcg tggaagttgg ctcgaagcta ttttcgatat taatgactta 540atttatatcc atattgatag aaaaaaacgt agaagaaaaa ttctagcaat cacctttatc 600cgagctcttg gatactcttc agatgcagat atcatcgaag aattcttcac aataggagaa 660agttctctta gaagtgagaa agactttgct cttcttgttg gaaggatttt agcagacaat 720attattgatg aagcctcctc tctagtttat ggaaaagccg gagaaaagtt aagtacagca 780atgttaaaac ggatgctcga tgctggaatc gcttctgtta agattgctgt agatgctgat 840gaaaatcatc ctattatcaa aatgctcgct aaggatccta cagattcata cgaagccgct 900ttaaaagatt tttatcgtag actacgtcca ggagaacctg caactctagc taatgcacgt 960tctactatca tgaggctctt ctttgacccc aaacgttata atctaggacg tgtagggcgt 1020tataagctca atcgcaaact aggcttctct atagatgatg aagctctgtc tcaagttact 1080ttgagaaaag aagatgtgat cggagcctta aagtatctga ttcgtttgaa aatgggagat 1140gaaaaagctt gtgtagacga tattgatcat cttgctaatc gacgtgtccg ctctgtcgga 1200gaactcattc aaaatcaatg tcgttcagga cttgctagaa tggagaaaat tgttagagag 1260agaatgaatt tattcgattt ctcctcagat acgttgactc caggaaaagt tgtctctgct 1320aaaggtctcg ctagcgtgtt aaaagatttc tttggccgct cccagctttc gcagtttatg 1380gaccaaacca accctgtagc tgagttaact cacaaacgac gtctttctgc attaggtcca 1440ggaggactaa atagagaacg cgcaggattt gaagttcgtg acgtgcacgc aagtcattat 1500ggacgtattt gtcctattga aactcctgaa ggtccaaata ttggtctgat cacctctctt 1560tcctcttttg ctaaaattaa cgaatttgga ttcattgaaa ctccttatag aattgtaaga 1620gatggaatcg taacagatga aatcgaatac atgacagccg atgttgaaga agaatgtgtg 1680attgcacagg cttcagcaag cctagatgag tacaatatgt ttacggaacc cgtctgttgg 1740gtacgttatg ctggagaagc tttcgaagca gatacaagca ccgtaaccca tatggatgtt 1800tctccgaaac agctcgtttc tattgttaca ggattgattc ctttcttaga gcacgacgat 1860gcgaaccgcg ccttgatggg ctccaatatg caacgtcaag cggttccctt acttaaaacc 1920gaagctcctg ttgttggcac tggattagaa tgtcgtgctg ctaaagattc tggagctatt 1980gttgttgcag aagaagatgg tgttgttgat tttgttgatg gttacaaagt agttgttgct 2040gcaaaacata atcctacaat taaacgtacc tatcatctga aaaagttcct tagatctaat 2100tcaggaactt gcattaacca acagcccttg tgtgcagtcg gtgatgtcat aactaagggt 2160gatgtgattg ctgatggacc cgcaactgat cgtggagaac ttgctttagg taaaaatgta 2220ctcgttgcct ttatgccttg gtatggatac aactttgagg atgcgatcat tatctctgaa 2280aaattgatca gagaagatgc ctatacctct atttatattg aggaattcga actaacagcc 2340cgagatacaa aattaggaaa agaagagatc actcgtgaca ttcctaacgt atctgatgaa 2400gtattggcca atctcggtga ggatgggatc attcgtatcg gtgctgaggt taaacctggg 2460gatattcttg ttggtaagat cacaccaaaa tcagaaacag aattagctcc agaagagcgt 2520ctgctccgtg ctatttttgg tgaaaaagct gctgacgtta aagatgcatc tttaacagtg 2580cctccaggaa ctgaaggcgt cgttatggat gttaaagtct tcagtagaaa ggatagattg 2640tcaaagagtg atgacgaact tgtagaagaa gctgttcatc ttaaagattt gcaaaaagga 2700tataaaaacc aagttgcaac tttaaaaaca gaatatcgtg agaaattagg agctctctta 2760ttaaatgaga aagcacctgc agccattatt caccgtcgta cagcagaaat cgttgttcat 2820gaaggcctac tctttgatca agagacaata gaacggatag aacaagaaga tttagtggat 2880cttttaatgc ctaactgtga aatgtatgaa gtgttgaaag gacttctatc agattacgaa 2940acggcattac aacggctaga aatcaattat aagactgaag ttgagcatat tcgtgaggga 3000gatgcagatt tagatcatgg tgtcattcgc caagttaaag tctacgttgc ctctaagaga 3060aaacttcaag ttggagataa aatggctgga cgacacggaa ataaaggtgt tgtttccaaa 3120atcgttcccg aagcggatat gccatatctc tctaacggag aaactgtaca aatgatcctg 3180aaccccctcg gggtgccttc aaggatgaac cttggacagg tattagaaac acacctaggt 3240tatgcagcaa aaactgcagg catttacgtg aaaacccctg tttttgaagg attccctgaa 3300caacgtatct gggatatgat gatagaacag ggattaccag aagatgggaa gtccttctta 3360tatgatggga agacaggtga acgctttgat aacaaggtag tgataggcta tatctatatg 3420ctaaagctca gtcacttgat cgctgataag attcacgcaa gatctatagg gccatattct 3480ttagtcacgc aacaacctct cggtggtaaa gctcagatgg gaggacaaag attcggggaa 3540atggaagttt gggctctaga agcatatggg gttgctcata tgctccaaga aattctaacc 3600gtgaaatctg atgatgtctc aggaagaaca aggatttacg aatctatcgt taagggggaa 3660aacctcttgc gatcaggaac gcctgagtcg ttcaatgtgc taattaaaga gatgcagggt 3720ctaggacttg atgttcgtcc tatggtcgta gacgcttaa 3759<210>377<211>675<212>DNA<213>肺炎衣原体<400>377atgacatcct ggatagaatt acttgataag caaattgaag atcaacatat gttaaagcac 60gaattttatc agcgttggtc tgaaggaaag ttagaaaaac aacaacttca agcttatgcc 120aaagattact atttacatat taaagcattt ccttgttacc tttcagcgct gcatgctcgc 180tgtgatgact tgcagattcg tagacaaatt cttgagaatc tcatggatga agaagctgga 240aatcctaatc acatagattt atggagacag tttgctttat ctcttggagt ttctgaagag 300gagcttgcca atcatgaatt cagtcaggct gctcaagata tggtagcgac atttcgccgc 360ttatgcgaca tgccacaact tgccgtgggt ttaggcgctc tctatactta tgagattcag 420attcctcaag tctgtgtaga gaaaatccgt ggtttgaaag aatattttgg agtttctgct 480cgaggctatg catactttac tgtacatcaa gaagctgata ttaaacatgc cagcgaagag 540aaagaaatgc tacaaacttt ggtaggcaga gagaatcctg atgctgtttt gcaaggatca 600caagaagttt tagatactct atggaacttt ttgagctctt ttattaattc aacggagcct 660tgttcttgta agtag 675<210>378<211>1671<212>DNA<213>肺炎衣原体<400>378atgtccaaac tcatcagacg agtagttacg gtccttgcgc taacgagtat ggcgagttgc 60tttgccagcg ggggtataga ggccgctgta gcagagtctc tgattactaa gatcgtcgct 120agtgcggaaa caaagccagc acctgttcct atgacagcga agaaggttag acttgtccgt 180agaaataaac aaccagttga acaaaaaagc cgtggtgctt tttgtgataa agaattttat 240ccctgtgaag agggacgatg tcaacctgta gaggctcagc aagagtcttg ctacggaaga 300ttgtattctg taaaagtaaa cgatgattgc aacgtagaaa tttgccagtc cgttccagaa 360tacgctactg taggatctcc ttaccctatt gaaatccttg ctataggcaa aaaagattgt 420gttgatgttg tgattacaca acagctacct tgcgaagctg aattcgtaag cagtgatcca 480gaaacaactc ctacaagtga tgggaaatta gtctggaaaa tcgatcgcct gggtgcagga 540gataaatgca aaattactgt atgggtaaaa cctcttaaag aaggttgctg cttcacagct 600gctactgtat gtgcttgccc agagctccgt tcttatacta aatgcggtca accagccatt 660tgtattaagc aagaaggacc tgactgtgct tgcctaagat gccctgtatg ctacaaaatc 720gaagtagtga acacaggatc tgctattgcc cgtaacgtaa ctgtagataa tcctgttccc 780gatggctatt ctcatgcatc tggtcaaaga gttctctctt ttaacttagg agacatgaga 840cctggcgata aaaaggtatt tacagttgag ttctgccctc aaagaagagg tcaaatcact 900aacgttgcta ctgtaactta ctgcggtgga cacaaatgtt ctgcaaatgt aactacagtt 960gttaatgagc cttgtgtaca agtaaatatc tctggtgctg attggtctta cgtatgtaaa 1020cctgtggagt actctatctc agtatcgaat cctggagact tggttcttca tgatgtcgtg 1080atccaagata cactcccttc tggtgttaca gtactcgaag ctcctggtgg agagatctgc 1140tgtaataaag ttgtttggcg tattaaagaa atgtgcccag gagaaaccct ccagtttaaa 1200cttgtagtga aagctcaagt tcctggaaga ttcacaaatc aagttgcagt aactagtgag 1260tctaactgcg gaacatgtac atcttgcgca gaaacaacaa cacattggaa aggtcttgca 1320gctacccata tgtgcgtatt agacacaaat gatcctatct gtgtaggaga aaatactgtc 1380tatcgtatct gtgtaactaa ccgtggttct gctgaagata ctaacgtatc tttaatcttg 1440aagttctcaa aagaacttca gccaatagct tcttcaggtc caactaaagg aacgatttca 1500ggtaataccg ttgttttcga cgctttacct aaactcggtt ctaaggaatc tgtagagttt 1560tctgttacct tgaaaggtat tgctcccgga gatgctcgcg gcgaagctat tctttcttct 1620gatacactga cttcaccagt atcagacaca gaaaataccc acgtgtatta a 1671<210>379<211>1386<212>DNA<213>肺炎衣原体<400>379atgacccaag aatttgattg tgttgttatt ggtgcgggac ctagtggcta tgttgccgca 60atcactgctg cgcaatcaaa attacggacc gctcttattg aagaagacca ggctgggggg 120acctgcttaa accgcggatg catcccttca aaagccctca ttgctggagc caatgttgta 180tctcacatta agcatgcgga gcagttcggc atccatgttg atggttatac aatcgattac 240cctgcgatgg caaaaagaaa aaatacagtc gtccagggga tccgtcaagg attagaagga 300ttgatccgca gcaacaagat tactgtctta aaaggaaccg gatctctagt atcttctaca 360gaagttaaag ttattggcca agacacgact ataatcaaag ccaatcatat tatcctagct 420acaggatccg agcctcgtcc tttcccaggg gttcccttct cctctagaat tttgagttcc 480acagggatct tagaacttga agtcctccct aaaaagctcg ctattattgg tggcggcgtt 540attggctgtg aatttgcgtc tctatttcac actttaggcg ttgagattac cgttatagaa 600gctttggatc atattcttgc ggttaacaat aaagaagttt ctcaaaccgt aacgaataaa 660tttacgaaac aaggaattcg aattcttacc aaagcctcga tctctgcaat cgaagaatcc 720caaaaccaag ttcgcattac tgtgaacgat caagtggaag agtttgatta tgtcttggtg 780gctattggtc gccaatttaa tacagcaagt atagggctag ataatgctgg agtgatccgg 840gacgatcgtg gcgtgattcc tgttgacgaa accatgcgca ctaatgttcc aaatatctat 900gcgattggag acatcactgg aaagtggcta cttgctcatg tggcttcgca ccaaggcgtt 960attgccgcga aaaatatttc gggacatcac gaagttatgg attattctgc cataccttct 1020gtgatcttta cccacccaga aattgctatg gtaggtctat ctctacaaga agcagaacaa 1080caaaatcttc ctgcaaagct caccaaattt ccttttaaag cgattggaaa agctgttgct 1140ttgggagcat ctgatggttt tgctgctatt gtgagtcatg aaattaccca gcaaatactc 1200ggagcttatg tcataggacc tcacgcctca tcattaattg gagagatgac cttagcgatc 1260cgcaatgagc tgaccctacc ttgcatatat gaaaccgtgc atgctcatcc cacactctct 1320gaagtttggg ctgaaggtgc tttacttgct acaaatcacc ctttacactt ccctcctaag 1380tcatga 1386<210>380<211>1635<212>DNA<213>肺炎衣原体<400>380atggcagcga aaaatattaa atataatgaa gaagccagaa aaaaaataca taaaggggta 60aaaactcttg cagaagcagt aaaagttact ctaggtccta aaggacgtca cgtagttata 120gataagagct ttggctctcc ccaagtgact aaagatggtg ttactgtagc taaagaaatc 180gagctcgaag acaaacatga aaacatgggc gctcagatgg taaaagaagt cgccagcaaa 240actgctgaca aagcaggcga cggaactaca acagcaactg ttcttgcaga agcaatctat 300agcgaaggtc taagaaatgt cactgccggt gccaatccta tggacctaaa aagaggtatc 360gacaaagccg taaaagttgt tgttgatgaa ctcaaaaaaa ttagtaaacc tgtacaacat 420cacaaagaaa tcgctcaagt agctactatc tcagcaaata atgattccga aatcggaaat 480cttattgcag aagctatgga aaaagttggt aaaaacggat ccattactgt tgaagaagct 540aaaggcttcg aaactgttct cgacgttgta gaaggaatga acttcaaccg tggatacctc 600tccagctact tctccacaaa tccagaaact caagaatgcg ttttagaaga cgctctgatt 660ctaatctacg ataaaaaaat ctctggaatt aaagacttcc ttccagtttt acaacaagta 720gcagaatctg gacgccctct tttaatcatt gcagaagaaa ttgaaggaga agctttagca 780actctagtag tcaatagact ccgtgcagga ttcagagtct gtgcagtgaa agctcctggt 840ttcggtgaca gaagaaaagc tatgttagaa gacatcgcta tccttactgg tggccaacta 900gttagcgaag aacttggcat gaaactagag aatacaactc tagcaatgtt aggaaaagct 960aagaaagtta tcgtaactaa agaagatacc acaatcgtcg aaggcttagg aaacaaacct 1020gatatccaag ctcgatgcga caatattaaa aaacaaatcg aagatagcac ttcagattac 1080gacaaagaaa aactccaaga gcgtttagct aaactctccg gtggtgtcgc cgtaatccgc 1140gtaggagctg ctaccgaaat agagatgaaa gagaaaaaag acagagtaga tgatgcacaa 1200cacgcaacca ttgcagctgt cgaagaagga atcctccctg gtggtggaac tgccttagtt 1260cgctgtatcc ctacactaga agctttcctt cctatgctag caaacgaaga cgaagctatt 1320ggtactcgta ttattctaaa agcattaaca gctccattaa agcaaattgc aagtaacgca 1380ggtaaagaag gcgctatcat ttgtcagcaa gttctagcaa gatctgcaaa tgaaggctat 1440gatgctttac gtgacgctta tacagatatg attgacgcag gaattttaga tccaactaaa 1500gtgactcgct cagctctaga aagcgcagct tctatcgcag gattactcct cacaacagaa 1560gccttaatcg ctgatatccc agaagagaaa tcttcttcag ctccagcgat gccaagcgca 1620ggaatggact actag 1635<210>381<211>1995<212>DNA<213>肺炎衣原体<400>381atggaaaaag tttcttctta tccctcagtt cctttacctc ttggggcttc taaaatttcc 60ccaaaccgct atcgatttgc tttatatgct tcacaagcta ccgaagtcat ccttgcttta 120acagacgaaa attcagaagt catagaagtc cctctttacc ccgatacaca ccgcacgggt 180gcgatttggc atatagagat cgagggtatt tctgatcaat cgtcttatgc atttcgtgtt 240catgggccta aaaagcatgg aatgcaatac tcttttaaag aatatcttgc agatccctat 300gcgaagaata ttcattcccc acagagtttt ggttcgcgaa agaaacaggg ggattatgca 360ttttgttatt taaaggaaga accatttcct tgggatggtg atcagcctct gcatttgccg 420aaagaagaga tgatcatcta tgagatgcat gtacgttcct tcacgcaatc ttcttcatct 480agggttcatg ctccgggaac cttcctagga atcattgaaa agatcgacca tctgcataag 540ctgggaatca acgctgttga actcttacct atctttgagt tcgatgagac tgcgcatcct 600tttagaaatt cgaaattccc ttatctgtgc aattattggg gttatgctcc cctaaatttc 660ttttctcctt gccgacgtta tgcttatgcc tctgatcctt gcgctccaag tagagagttt 720aaaactttag taaagacctt gcatcaagaa ggtattgagg tcattcttga tgttgttttt 780aatcatacgg gcttgcaagg gacgacctgc tctttgcctt ggatagacac tccgagctat 840tatattttag atgcacaagg tcactttaca aattattcag gctgtggaaa cactctcaat 900acaaaccgcg cccccacgac ccaatggatt ctcgacatct tacgttattg ggtagaagaa 960atgcatgtcg atgggttccg atttgatctt gcttctgtct tttctcgtgg tccttcggga 1020tctcccctac aattcgctcc tgttttagag gcgatttctt ttgatccttt acttgcgagc 1080acaaagatta tagctgagcc ttgggatgct ggcggtttgt atcaggtggg ctatttcccc 1140acactgtctc caagatggag tgaatggaac ggcccgtatc gtgataacgt gaaagcattt 1200cttaatgggg atcaaaatct cataggaacc tttgcttcta gaatttcagg atctcaagac 1260atctatcctc acggctcgcc tacaaattcg attaactatg tcagttgcca tgatggtttt 1320acgttatgtg acactgtgac ttataaccac aaacataatg aggctaacgg agaggataat 1380cgtgacggca cagatgcgaa ctacagctac aatttcggaa cggaagggaa aacagaagac 1440cctggcattc ttgaagttcg tgaaagacag ttacgaaatt ttttccttac tttgatggtc 1500tcgcaaggca ttccgatgat tcaatcagga gatgagtatg cccataccgc ggaaggcaat 1560aacaaccgtt gggctttgga ttcgaatgcg aattacttcc tttgggatca gcttaccgca 1620aagcctacac tgatgcactt tctctgtgat ctcattgcgt ttcgaaaaaa atataaaaca 1680ctttttaatc gaggctttct ttccaataag gaaatcagtt gggtagatgc tatgggaaat 1740cccatgacat ggcgccctgg aaatttctta gcatttaaaa taaaatcgcc aaaagcgcat 1800gtatatgttg cttttcacgt gggagctcaa gaccaacttg cgaccttacc taaagcctcc 1860agcaactttc ttccttatca aatagttgcc gagagtcagc aagggtttgt ccctcaaaat 1920gtagcaacgc cgacagtgtc gctacagccc cataccacgc taattgcgat cagccatgcg 1980aaagaggtta cctga 1995<210>382<211>987<212>DNA<213>肺炎衣原体<400>382atggcattca aagaggtcgt tcgtgttgct gtcacaggag gcaaagggca gattgcgtat 60aattttttat ttgcattagc ccatggagat gtttttggag tggatcgtgg tgtagattta 120cggatctatg atgtgccggg tacagagaga gctctctcag gggtgcgtat ggagctcgat 180gacggtgcat atcctctttt acatcgtctg cgtgtgacga catcgttaaa cgacgctttt 240gatggtatcg atgcggcgtt tctgataggt gctgtgcctc gtggacccgg tatggagcga 300ggagatcttt taaagcaaaa tggtcagatc ttttcgttac agggggccgc tttaaataca 360gcagcaaaaa gagatgctaa gatttttgtt gtagggaacc ctgtcaatac gaattgctgg 420attgctatga aacatgctcc cagattgcat cggaaaaatt tccatgcgat gttacgcttg 480gatcagaatc gcatgcatag catgctcgct catcgtgctg aggttcctct agaggaggtc 540tcccgtgttg tcatctgggg aaatcattct gcaaagcagg ttcctgactt cacacaagca 600cgtatctcag ggaaacccgc agccgaggtt atcggagatc gagattggtt ggaaaacatt 660ttagtacact ccgtgcagaa tcgtggaagc gctgtaattg aagcaagagg gaaatcttcg 720gcagcatccg catctcgagc acttgccgag gccgcgcgat ctattttttg tcctaaaagt 780gacgagtggt tttcttctgg agtgtgttcg gatcataatc cttatggtat tcctgaagac 840ttgatttttg gttttccatg tcgtatgttg ccttctggag attatgaaat cattcctgga 900ttgccttggg agccttttat cagaaataag attcaaattt ccctggatga aattgctcag 960gaaaaagcta gcgtgtcttc gttataa 987<210>383<211>654<212>DNA<213>肺炎衣原体<400>383atgaaaagag tcatttataa aaccatattt tgcgggttaa ctttacttac aagtttgagt 60agttgttccc tggatcctaa aggatataac ctagagacaa aaaactcgag ggacttaaat 120caagagtctg ttatactgaa ggaaaaccgt gaaacacctt ctcttgttaa gagactctct 180cgtcgttctc gaagactctt cgctcgacgt gatcaaactc agaaggatac gctgcaagtg 240caagctaact ttaagaccta cgcagaaaag atttcagagc aggacgaaag agacctttct 300ttcgttgtct cgtctgctgc agaaaagtct tcaatttcgt tagctttgtc tcagggtgaa 360attaaggatg ctttgtaccg tatccgagaa gtccaccctc tagctttaat agaagctctt 420gctgaaaacc ctgccttgat agaagggatg aaaaagatgc aaggccgtga ttggatttgg 480aatcttttct taacacaatt aagtgaagta ttttctcaag cttggtctca aggggttatc 540tctgaagaag atatcgccgc atttgcctcc accttaggtt tggactccgg gaccgttgcg 600tccattgtcc aaggggaaag gtggcccgag cttgtggata tagtgataac ttaa 654<210>384<211>813<212>DNA<213>肺炎衣原体<400>384atgatcataa taaaaaacaa tgagctcatg ataagacgtt ttttcaaaac gcttttccct 60ccgggtcctc aatactcttt atgttatgct tcgatcctga tcgttttgag ttcccttgtt 120tgtgttccta cattttgttg gttatttctc cctgaactgt ctttatctaa attcaatcct 180tctcccatta ggaacctatt tttagtttcc tccactctat ccaaagtccc tcctactgcg 240attgcagaac atttacgtct ttctgcggat gcacctacat atctccatga attctctatt 300aaagaagctg agtcgagctt gcatgctctt gggatttttt cctctttagt tatagaaaaa 360tctcctgata ataagggcat tacaattttc tataccttac aaacacctat tgcttatgtt 420gggaaccgat ctaatacgtt atgcaatctc gaggggagct gctttcttgg tcaaccgtac 480ttcccctctc tgaatctccc tcagattttt ttctctcaag aagatttaaa aatgcaaaaa 540ctccctaaag aaaaaatgct ttttaccaag attcttctta aggagcttgc tatggagtct 600ccgaaaatca ttgatttatc tttatctgat gcataccctg gagaaattat agtgacgctc 660tcttcaggca gtctgttaag acttccaatt aagaccttag atcgtgcctt agacctgtat 720aagcacatga aaaaaagtcc tgtaatcgag agcgaaaaac aatatgtcta tgatttgcgt 780tttccaaatt tcttattatt aaaagctcta tga 813<210>385<211>1956<212>DNA<213>肺炎衣原体<400>385atggttaatc ctattggtcc aggtcctata gacgaaacag aacgcacacc tcccgcagat 60ctttctgctc aaggattgga ggcgagtgca gcaaataaga gtgcggaagc tcaaagaata 120gcaggtgcgg aagctaagcc taaagaatct aagaccgatt ctgtagagcg atggagcatc 180ttgcgttctg cagtgaatgc tctcatgagt ctggcagata agctgggtat tgcttctagt 240aacagctcgt cttctactag cagatctgca gacgtggact caacgacagc gaccgcacct 300acgcctcctc cacccacgtt tgatgattat aagactcaag cgcaaacagc ttacgatact 360atctttacct caacatcact agctgacata caggctgctt tggtgagcct ccaggatgct 420gtcactaata taaaggatac agcggctact gatgaggaaa ccgcaatcgc tgcggagtgg 480gaaactaaga atgccgatgc agttaaagtt ggcgcgcaaa ttacagaatt agcgaaatat 540gcttcggata accaagcgat tcttgactct ttaggtaaac tgacttcctt cgacctctta 600caggctgctc ttctccaatc tgtagcaaac aataacaaag cagctgagct tcttaaagag 660atgcaagata acccagtagt cccagggaaa acgcctgcaa ttgctcaatc tttagttgat 720cagacagatg ctacagcgac acagatagag aaagatggaa atgcgattag ggatgcatat 780tttgcaggac agaacgctag tggagctgta gaaaatgcta aatctaataa cagtataagc 840aacatagatt cagctaaagc agcaatcgct actgctaaga cacaaatagc tgaagctcag 900aaaaagttcc ccgactctcc aattcttcaa gaagcggaac aaatggtaat acaggctgag 960aaagatctta aaaatatcaa acctgcagat ggttctgatg ttccaaatcc aggaactaca 1020gttggaggct ccaagcaaca aggaagtagt attggtagta ttcgtgtttc catgctgtta 1080gatgatgctg aaaatgagac cgcttccatt ttgatgtctg ggtttcgtca gatgattcac 1140atgttcaata cggaaaatcc tgattctcaa gctgcccaac aggagctcgc agcacaagct 1200agagcagcga aagccgctgg agatgacagt gctgctgcag cgctggcaga tgctcagaaa 1260gctttagaag cggctctagg taaagctggg caacaacagg gcatactcaa tgctttagga 1320cagatcgctt ctgctgctgt tgtgagcgca ggagttcctc ccgctgcagc aagttctata 1380gggtcatctg taaaacagct ttacaagacc tcaaaatcta caggttctga ttataaaaca 1440cagatatcag caggttatga tgcttacaaa tccatcaatg atgcctatgg tagggcacga 1500aatgatgcga ctcgtgatgt gataaacaat gtaagtaccc ccgctctcac acgatccgtt 1560cctagagcac gaacagaagc tcgaggacca gaaaaaacag atcaagccct cgctagggtg 1620atttctggca atagcagaac tcttggagat gtctatagtc aagtttcggc actacaatct 1680gtaatgcaga tcatccagtc gaatcctcaa gcgaataatg aggagatcag acaaaagctt 1740acatcggcag tgacaaagcc tccacagttt ggctatcctt atgtgcaact ttctaatgac 1800tctacacaga agttcatagc taaattagaa agtttgtttg ctgaaggatc taggacagca 1860gctgaaataa aagcactttc ctttgaaacg aactccttgt ttattcagca ggtgctggtc 1920aatatcggct ctctatattc tggttatctc caataa 1956<210>386<211>805<212>PRT<213>肺炎衣原体<400>386Met Asp Pro Lys Glu Lys Asn Tyr Asp Ala Ser Ala Ile Thr Val Leu

5 10 15Glu Gly Leu Gln Ala Val Arg Glu Arg Pro Gly Met Tyr Ile Gly Asp

20 25 30Thr Gly Ile Thr Gly Leu His His Leu Val Tyr Glu Val Val Asp Asn

35 40 45Ser Ile Asp Glu Ala Met Ala Gly Tyr Cys Ser Arg Ile Asp Val Arg

50 55 60Ile Leu Glu Asp Gly Gly Ile Val Ile Val Asp Asn Gly Arg Gly Ile65 70 75 80Pro Ile Glu Val His Glu Arg Glu Ser Ala Lys Gln Gly Arg Glu Val

85 90 95Ser Ala Leu Glu Val Val Leu Thr Val Leu His Ala Gly Gly Lys Phe

100 105 110Asp Lys Asp Ser Tyr Lys Val Ser Gly Gly Leu His Gly Val Gly Val

115 120 125Ser Cys Val Asn Ala Leu Ser Glu Lys Leu Val Ala Thr Val Phe Lys

130 135 140Asp Lys Lys Cys Tyr Gln Met Glu Phe Ser Arg Gly Ile Pro Val Thr145 150 155 160Pro Leu Gln Tyr Val Ser Val Ser Asp Arg Gln Gly Thr Glu Ile Val

165 170 175Phe Tyr Pro Asp Pro Lys Ile Phe Ser Thr Cys Thr Phe Asp Arg Ser

180 185 190Ile Leu Met Lys Arg Leu Arg Glu Leu Ala Phe Leu Asn Arg Gly Ile

195 200 205Thr Ile Val Phe Glu Asp Asp Arg Asp Val Ser Phe Asp Lys Val Thr

210 215 220Phe Phe Tyr Glu Gly Gly Ile Gln Ser Phe Val Ser Tyr Leu Asn Gln225 230 235 240Asn Lys Glu Ser Leu Phe Ser Glu Pro Ile Tyr Ile Cys Gly Thr Arg

245 250 255Val Gly Asp Asp Gly Glu Ile Glu Phe Glu Ala Ala Leu Gln Trp Asn

260 265 270Ser Gly Tyr Ser Glu Leu Val Tyr Ser Tyr Ala Asn Asn Ile Pro Thr

275 280 285Arg Gln Gly Gly Thr His Leu Thr Gly Phe Ser Thr Ala Leu Thr Arg

290 295 300Val Ile Asn Thr Tyr Ile Lys Ala His Asn Leu Ala Lys Asn Asn Lys305 310 315 320Leu Ala Leu Thr Gly Glu Asp Ile Arg Glu Gly Leu Thr Ala Val Ile

325 330 335Ser Val Lys Val Pro Asn Pro Gln Phe Glu Gly Gln Thr Lys Gln Lys

340 345 350Leu Gly Asn Ser Asp Val Ser Ser Val Ala Gln Gln Val Val Gly Glu

355 360 365Ala Leu Thr Ile Phe Phe Glu Glu Asn Pro Gln Ile Ala Arg Met Ile

370 375 380Val Asp Lys Val Phe Val Ala Ala Gln Ala Arg Glu Ala Ala Lys Lys385 390 395 400Ala Arg Glu Leu Thr Leu Arg Lys Ser Ala Leu Asp Ser Ala Arg Leu

405 410 415Pro Gly Lys Leu Ile Asp Cys Leu Glu Lys Asp Pro Glu Lys Cys Glu

420 425 430Met Tyr Ile Val Glu Gly Asp Ser Ala Gly Gly Ser Ala Lys Gln Gly

435 440 445Arg Asp Arg Arg Phe Gln Ala Ile Leu Pro Ile Arg Gly Lys Ile Leu

450 455 460Asn Val Glu Lys Ala Arg Leu Gln Lys Ile Phe Gln Asn Gln Glu Ile465 470 475 480Gly Thr Ile Ile Ala Ala Leu Gly Cys Gly Ile Gly Ala Asp Asn Phe

485 490 495Asn Leu Ser Lys Leu Arg Tyr Arg Arg Ile Ile Ile Met Thr Asp Ala

500 505 510Asp Val Asp Gly Ser His Ile Arg Thr Leu Leu Leu Thr Phe Phe Tyr

515 520 525Arg His Met Thr Ala Leu Ile Glu Asn Glu Cys Val Tyr Ile Ala Gln

530 535 540Pro Pro Leu Tyr Lys Val Ser Lys Lys Lys Asp Phe Arg Tyr Ile Leu545 550 555 560Ser Glu Lys Glu Met Asp Ser Tyr Leu Leu Met Leu Gly Thr Asn Glu

565 570 575Ser Ser Ile Leu Phe Lys Ser Thr Glu Arg Glu Leu Arg Gly Glu Ala

580 585 590Leu Glu Ser Phe Ile Asn Val Ile Leu Asp Val Glu Ser Phe Ile Asn

595 600 605Thr Leu Glu Lys Lys Ala Ile Pro Phe Ser Glu Phe Leu Glu Met Tyr

6l0 615 620Lys Glu Gly Ile Gly Tyr Pro Leu Tyr Tyr Leu Ala Pro Ala Thr Gly625 630 635 640Met Gln Gly Gly Arg Tyr Leu Tyr Ser Asp Glu Glu Lys Glu Glu Ala

645 650 655Leu Ala Gln Glu Glu Thr His Lys Phe Lys Ile Ile Glu Leu Tyr Lys

660 665 670Val Ala Val Phe Val Asp Ile Gln Asn Gln Leu Lys Glu Tyr Gly Leu

675 680 685Asp Ile Ser Ser Tyr Leu Ile Pro Gln Lys Asn Glu Ile Val Ile Gly

690 695 700Asn Glu Asp Ser Pro Ser Cys Asn Tyr Ser Cys Tyr Thr Leu Glu Glu705 710 715 720Val Ile Asn Tyr Leu Lys Asn Leu Gly Arg Lys Gly Ile Glu Ile Gln

725 730 735Arg Tyr Lys Gly Leu Gly Glu Met Asn Ala Asp Gln Leu Trp Asp Thr

740 745 750Thr Met Asn Pro Glu Gln Arg Thr Leu Ile His Val Ser Leu Lys Asp

755 760 765Ala Val Glu Ala Asp His Ile Phe Thr Met Leu Met Gly Glu Glu Val

770 775 780Pro Pro Arg Arg Glu Phe Ile Glu Ser His Ala Leu Ser Ile Arg Ile785 790 795 800Asn Asn Leu Asp Ile

805<210>387<211>295<212>PRT<213>肺炎衣原体<400>387Met Glu Lys Leu Leu Val Thr Asp Ile Asp Gly Thr Ile Thr His Gln

5 10 15Ser His His Leu Asp Lys Lys Val Tyr Glu Arg Leu Tyr Ala Leu His

20 25 30Gln Ala Gly Trp Lys Leu Phe Phe Leu Thr Gly Arg Tyr Tyr Lys Tyr

35 40 45Ala Ala Arg Leu Phe Ser Asp Phe Asp Ala Pro Tyr Leu Leu Gly Cys

50 55 60Gln Asn Gly Ala Ser Val Trp Ser Ser Thr Ser Ser Asn Leu Leu Tyr65 70 75 80Ser Lys Ser Leu Pro Ser Asp Leu Leu Cys Ile Leu Gln Asp Cys Met

85 90 95Glu Gly Ala Thr Ala Leu Phe Ser Val Glu Ser Gly Ala Pro Tyr Gly

100 105 110Asp His Tyr Tyr Arg Phe Ser Pro Thr Pro Ile Ala Gln Asp Leu His

115 120 125Glu Tyr Val Asp Pro Arg Tyr Phe Pro Asn Ala Lys Glu Arg Glu Ile

130 135 140Leu Phe Glu Thr Arg Ser Leu Lys Asp Asp Tyr Ala Phe Pro Ser Phe145 150 155 160Ala Ala Ala Lys Val Phe Gly Leu Arg Asp Glu Val Ile Arg Ile Gln

165 170 175Lys Glu Leu Glu Arg Gln Glu Ala Leu Thr Ser Val Ala Thr Met Thr

180 185 190Leu Met Arg Trp Pro Phe Asp Phe Arg Tyr Ala Ile Leu Phe Leu Thr

195 200 205Asp Lys Ser Val Ser Lys Gly Lys Ala Leu Asp Arg Val Val Asn Ile

210 215 220Leu Tyr Asp Gly Lys Lys Pro Phe Val Met Ala Ser Gly Asp Asp Ala225 230 235 240Asn Asp Leu Asp Leu Ile Glu Arg Gly Asp Phe Lys Ile Val Met Ser

245 250 255Ser Ala Pro Glu Glu Met His Val His Ala Asp phe Leu Ala Pro Pro

260 265 270Ala Asp Lys Asn Gly Ile Leu Ser Ala Trp Glu Ala Gly Val Arg Tyr

275 280 285Tyr Asp Asp Leu Met Ser Leu

290 295<210>388<211>78<212>PRT<213>肺炎衣原体<400>388Met Lys Glu Phe Leu Ala Tyr Ile Ile Lys Asn Leu Val Asp Arg Pro

5 10 15Glu Glu Val Arg Ile Lys Glu Val Gln Gly Thr His Thr Ile Ile Tyr

20 25 30Glu Leu Ser Val Ala Lys Pro Asp Ile Gly Lys Ile Ile Gly Lys Glu

35 40 45Gly Arg Thr Ile Lys Ala Ile Arg Thr Leu Leu Val Ser Val Ala Ser

50 55 60Arg Asn Asn Val Arg Val Ser Leu Glu Ile Met Glu Glu Lys65 70 75<210>389<211>478<212>PRT<213>肺炎衣原体<400>389Met Arg Asp Val Ser Glu Leu Phe Arg Thr His Phe Met His Tyr Ala

5 10 15Ser Tyr Val Ile Leu Glu Arg Ala Ile Pro His Ile Leu Asp Gly Leu

20 25 30Lys Pro Val Gln Arg Arg Leu Leu Trp Thr Leu Phe Leu Met Asp Asp

35 40 45Gly Lys Met His Lys Val Ala Asn Ile Ala Gly Arg Thr Met Ala Leu

50 55 60His Pro His Gly Asp Ala Pro Ile Val Glu Ala Leu Val Val Leu Ala65 70 75 80Asn Lys Gly Tyr Leu Ile Asp Thr Gln Gly Asn Phe Gly Asn Pro Leu

85 90 95Thr Gly Asp Pro His Ala Ala Ala Arg Tyr Ile Glu Ala Arg Leu Ser

100 105 110Pro Leu Ala Arg Glu Thr Leu Phe Asn Thr Asp Leu Ile Ala Phe His

115 120 125Asp Ser Tyr Asp Gly Arg Glu Lys Glu Pro Asp Ile Leu Pro Ala Lys

130 135 140Leu Pro Val Leu Leu Leu His Gly Val Asp Gly Ile Ala Val Gly Met145 150 155 160Thr Thr Lys Ile Phe Pro His Asn Phe Ala Glu Leu Leu Lys Ala Gln

165 170 175Ile Ala Ile Leu Asn Asp Lys Lys Phe Thr Val Phe Pro Asp Phe Pro

180 185 190Ser Gly Gly Leu Met Asp Pro Ser Glu Tyr Gln Asp Gly Leu Gly Ser

195 200 205Ile Thr Leu Arg Ala Ser Ile Asp Ile Ile Asn Asp Lys Thr Leu Val

210 215 220Val Lys Gln Ile Cys Pro Gln Ser Thr Thr Glu Thr Leu Ile Arg Ser225 230 235 240Ile Glu Asn Ala Ala Lys Arg Gly Thr Ile Lys Ile Asp Thr Ile Gln

245 250 255Asp Phe Ser Thr Asp Val Pro His Ile Glu Ile Lys Leu Pro Lys Gly

260 265 270Ser Arg Ala Lys Glu Met Lau Pro Leu Leu Phe Glu His Thr Glu Cys

275 280 285Gln Val Ile Leu Tyr Ser Lys Pro Thr Val Ile Tyr Glu Asn Lys Pro

290 295 300Val Glu Cys Ser Ile Ser Glu Ile Leu Lys Leu His Thr Thr Ala Leu305 310 315 320Gln Gly Tyr Leu Glu Lys Glu Leu Leu Leu Leu Gln Glu Gln Leu Thr

325 330 335Leu Asp His Tyr His Lys Thr Leu Glu Tyr Ile Phe Ile Lys His Lys

340 345 350Leu Tyr Asp Ser Val Arg Glu Val Leu Ala Ile Asn Lys Lys Ile Ser

355 360 365Ala Asp Asp Leu His Gln Ala Val Leu His Ala Leu Glu Pro Trp Leu

370 375 380His Glu Leu Ala Thr Pro Val Thr Lys Gln Asp Thr Ser Gln Leu Ala385 390 395 400Ser Leu Thr Ile Lys Lys Ile Leu Cys Phe Asn Glu Glu Ala Cys Thr

405 410 415Lys Glu Leu Leu Ala Ile Glu Lys Lys Gln Ala Ala Ile Gln Lys Asp

420 425 430Leu Gly Arg Ile Lys Glu Val Thr Val Lys Tyr Leu Lys Gly Leu Leu

435 440 445Glu Arg His Gly His Leu Gly Glu Arg Lys Thr Gln Ile Thr Asn Phe

450 455 460Lys Thr Ala Lys Thr Ser Ile Leu Lys Gln Gln Thr Leu Ile465 470 475<210>390<211>257<212>PRT<213>肺炎衣原体<400>390Met Ala Phe Tyr Ser Pro Ser Thr Ile Ser Lys Tyr Phe Ile Tyr Ser

5 10 15Gly Ala Gly Asn Arg Phe Leu Leu Gly Glu Thr Leu Pro Glu Val Glu

20 25 30Asp Val Arg Phe Leu Cys Gln Glu Thr Arg Val Asp Gly Phe Leu Tyr

35 40 45Leu Lys Pro Ser Ser Cys Ala Asp Ala Gln Leu Ile Ile Phe Asn Ser

50 55 60Asp Gly Ser Arg Pro Thr Met Cys Gly Asn Gly Leu Arg Cys Ala Ile65 70 75 80Ala His Leu Ala Ser Gln Lys Gly Lys Ser Asp Ile Ser Val Ser Thr

85 90 95Asp Ser Gly Leu Tyr Ser Gly Tyr Phe Tyr Ser Trp Asp Arg Val Leu

100 105 110Val Asp Met Thr Leu Ala Asp Trp Arg Ala Ser Val His Arg Leu Glu

115 120 125Ser Arg Pro Asp Pro Leu Pro Lys Glu Val Val Cys Ile His Thr Gly

130 135 140Val Pro His Ala Val Val Ile Leu Pro Glu Ile Ser Thr Leu Asp Leu145 150 155 160Ser Ile Leu Gly Pro Phe Leu Arg Tyr His Gln Thr Phe Ser Pro Asp

165 170 175Gly Val Asn Val Asn Phe Val Gln Ile Leu Gly His Cys Gln Leu Arg

180 185 190Val Arg Thr Tyr Glu Arg Gly Val Glu Gly Glu Thr Ala Ala Cys Gly

195 200 205Thr Gly Ala Leu Ala Ser Ala Leu Val Val Ser Asn Ser Tyr Gly Trp

210 215 220Lys Glu Ser Ile Gln Ile His Thr Trp Gly Gly Glu Leu Met Thr Val225 230 235 240Ser Gln Asn Arg Gly Arg Val Tyr Leu Gln Gly Ser Val Thr Arg Asp

245 250 255Leu<210>391<211>191<212>PRT<213>肺炎衣原体<400>391Met Ala Asp Gly Glu Val His Lys Leu Arg Asp Ile Ile Glu Lys Glu

5 10 15Leu Leu Glu Ala Arg Arg Val Phe Phe Ser Glu Pro Val Thr Glu Lys

20 25 30Ser Ala Ser Asp Ala Ile Lys Lys Leu Trp Tyr Leu Glu Leu Lys Asp

35 40 45Pro Gly Lys Pro Ile Val Phe Val Ile Asn Ser Pro Gly Gly Ser Val

50 55 60Asp Ala Gly Phe Ala Val Trp Asp Gln Ile Lys Met Leu Thr Ser Pro65 70 75 80Val Thr Thr Val Val Thr Gly Leu Ala Ala Ser Met Gly Ser Val Leu

85 90 95Ser Leu Cys Ala Ala Pro Gly Arg Arg Phe Ala Thr Pro His Ser Arg

100 105 110Ile Met Ile His Gln Pro Ser Ile Gly Gly Pro Ile Thr Gly Gln Ala

115 120 125Thr Asp Leu Asp Ile His Ala Arg Glu Ile Leu Lys Thr Lys Ala Arg

130 135 140Ile Ile Asp Val Tyr Val Glu Ala Thr Asn Gln Pro Arg Asp Ile Ile145 150 155 160Glu Lys Ala Ile Asp Arg Asp Met Trp Met Thr Ala Asn Glu Ala Lys

165 170 175Asp Phe Gly Leu Leu Asp Gly Ile Leu Phe Ser Phe Asn Asp Leu

180 185 190<210>392<211>232<212>PRT<213>肺炎衣原体<400>392Met Thr Lys His Gly Lys Arg Ile Arg Gly Ile Leu Lys Asn Tyr Asp

5 10 15Phe Ser Lys Ser Tyr Ser Leu Arg Glu Ala Ile Asp Ile Leu Lys Gln

20 25 30Cys Pro Pro Val Arg Phe Asp Gln Thr Val Asp Val Ser Ile Lys Leu

35 40 45Gly Ile Asp Pro Lys Lys Ser Asp Gln Gln Ile Arg Gly Ala Val Phe

50 55 60Leu Pro Asn Gly Thr Gly Lys Thr Leu Arg Ile Leu Val Phe Ala Ser65 70 75 80Gly Asn Lys Val Lys Glu Ala Val Glu Ala Gly Ala Asp Phe Met Gly

85 90 95Ser Asp Asp Leu Val Glu Lys Ile Lys Ser Gly Trp Leu Glu Phe Asp

100 105 110Val Ala Val Ala Thr Pro Asp Met Met Arg Glu Val Gly Lys Leu Gly

115 120 125Lys Val Leu Gly Pro Arg Asn Leu Met Pro Thr Pro Lys Thr Gly Thr

130 135 140Val Thr Thr Asp Val Ala Lys Ala Ile Ser Glu Leu Arg Lys Gly Lys145 150 155 160Ile Glu Phe Lys Ala Asp Arg Ala Gly Val Cys Asn Val Gly Val Gly

165 170 175Lys Leu Ser Phe Glu Ser Ser Gln Ile Lys Glu Asn Ile Glu Ala Leu

180 185 190Ser Ser Ala Leu Ile Lys Ala Lys Pro Pro Ala Ala Lys Gly Gln Tyr

195 200 205Leu Val Ser Phe Thr Ile Ser Ser Thr Met Gly Pro Gly Ile Ser Ile

210 215 220Asp Thr Arg Glu Leu Met Ala Ser225 230<210>393<211>122<212>PRT<213>肺炎衣原体<400>393Met Pro Arg Ile Ile Gly Ile Asp Ile Pro Ala Lys Lys Lys Leu Lys

5 10 15Ile Ser Leu Thr Tyr Ile Tyr Gly Ile Gly Ser Ala Arg Ser Asp Glu

20 25 30Ile Ile Lys Lys Leu Lys Leu Asp Pro Glu Ala Arg Ala Ser Glu Leu

35 40 45Thr Glu Glu Glu Val Gly Arg Leu Asn Ser Leu Leu Gln Ser Glu Tyr

85 90 95Pro Val Arg Gly Gln Arg Thr Lys Thr Asn Ser Arg Thr Arg Lys Gly

100 105 110Lys Arg Lys Thr Val Ala Gly Lys Lys Lys

115 120<210>394<211>1723<212>PRT<213>肺炎衣原体<400>394Met Lys Trp Leu Pro Ala Thr Ala Val Phe Ala Ala Val Leu Pro Ala

5 10 15Leu Thr Ala Phe Gly Asp Pro Ala Ser Val Glu Ile Ser Thr Ser His

20 25 30Thr Gly Ser Gly Asp Pro Thr Ser Asp Ala Ala Leu Thr Gly Phe Thr

35 40 45Gln Ser Ser Thr Glu Thr Asp Gly Thr Thr Tyr Thr Ile Val Gly Asp

50 55 60Ile Thr Phe Ser Thr Phe Thr Asn Ile Pro Val Pro Val Val Thr Pro65 70 75 80Asp Ala Asn Asp Ser Ser Ser Asn Ser Ser Lys Gly Gly Ser Ser Ser

85 90 95Ser Gly Ala Thr Ser Leu Ile Arg Ser Ser Asn Leu His Ser Asp Phe

100 105 110Asp Phe Thr Lys Asp Ser Val Leu Asp Leu Tyr His Leu Phe Phe Pro

115 120 125Ser Ala Ser Asn Thr Leu Asn Pro Ala Leu Leu Ser Ser Ser Ser Ser

130 135 140Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Ala Ser145 150 155 160Ala Val Val Ala Ala Asp Pro Lys Gly Gly Ala Ala Phe Tyr Ser Asn

165 170 175Glu Ala Asn Gly Thr Leu Thr Phe Thr Thr Asp Ser Gly Asn Pro Gly

180 185 190Ser Leu Thr Leu Gln Asn Leu Lys Met Thr Gly Asp Gly Ala Ala Ile

195 200 205Tyr Ser Lys Gly Pro Leu Val Phe Thr Gly Leu Lys Asn Leu Thr Phe

210 215 220Thr Gly Asn Glu Ser Gln Lys Ser Gly Gly Ala Ala Tyr Thr Glu Gly225 230 235 240Ala Leu Thr Thr Gln Ala Ile Val Glu Ala Val Thr Phe Thr Gly Asn

245 250 255Thr Ser Ala Gly Gln Gly Gly Ala Ile Tyr Val Lys Glu Ala Thr Leu

260 265 270Phe Asn Ala Leu Asp Ser Leu Lys Phe Glu Lys Asn Thr Ser Gly Gln

275 280 285Ala Gly Gly Gly Ile Tyr Thr Glu Ser Thr Leu Thr Ile Ser Asn Ile

290 295 300Thr Lys Ser Ile Glu Phe Ile Ser Asn Lys Ala Ser Val Pro Ala Pro305 310 315 320Ala Pro Glu Pro Thr Ser Pro Ala Pro Ser Ser Leu Ile Asn Ser Thr

325 330 335Thr Ile Asp Thr Ser Thr Leu Gln Thr Arg Ala Ala Ser Ala Thr Pro

340 345 350Ala Val Ala Pro Val Ala Ala Val Thr Pro Thr Pro Ile Ser Thr Gln

355 360 365Glu Thr Ala Gly Asn Gly Gly Ala Ile Tyr Ala Lys Gln Gly Ile Ser

370 375 380Ile Ser Thr Phe Lys Asp Leu Thr Phe Lys Ser Asn Ser Ala Ser Val385 390 395 400Asp Ala Thr Leu Thr Val Asp Ser Ser Thr Ile Gly Glu Ser Gly Gly

405 410 415Ala Ile Phe Ala Ala Asp Ser Ile GlnIle Gln Gln Cys Thr Gly Thr

420 425 430Thr Leu Phe Ser Gly Asn Thr Ala Asn Lys Ser Gly Gly Gly Ile Tyr

435 440 445Ala Val Gly Gln Val Thr Leu Glu Asp Ile Ala Asn Leu Lys Met Thr

450 455 460Asn Asn Thr Cys Lys Gly Glu Gly Gly Ala Ile Tyr Thr Lys Lys Ala465 470 475 480Leu Thr Ile Asn Asn Gly Ala Ile Leu Thr Thr Phe Ser Gly Asn Thr

485 490 495Ser Thr Asp Asn Gly Gly Ala Ile Phe Ala Val Gly Gly Ile Thr Leu

500 505 510Ser Asp Leu Val Glu Val Arg Phe Ser Lys Asn Lys Thr Gly Asn Tyr

515 520 525Ser Ala Pro Ile Thr Lys Ala Ala Ser Asn Thr Ala Pro Val Val Ser

530 535 540Ser Ser Thr Thr Ala Ala Ser Pro Ala Val Pro Ala Ala Ala Ala Ala545 550 555 560Pro Val Thr Asn Ala Ala Lys Gly Gly Ala Leu Tyr Ser Thr Glu Gly

565 570 575Leu Thr Val Ser Gly Ile Thr Ser Ile Leu Ser Phe Glu Asn Asn Glu

580 585 590Cys Gln Asn Gln Gly Gly Gly Ala Tyr Val Thr Lys Thr Phe Gln Cys

595 600 605Ser Asp Ser His Arg Leu Gln Phe Thr Ser Asn Lys Ala Ala Asp Glu

610 615 620Gly Gly Gly Leu Tyr Cys Gly Asp AsP Val Thr Leu Thr Asn Leu Thr625 630 635 640Gly Lys Thr Leu Phe Gln Glu Asn Ser Ser Glu Lys His Gly Gly Gly

645 650 655Leu Ser Leu Ala Ser Gly Lys Ser Leu Thr Met Thr Ser Leu Glu Ser

660 665 670Phe Cys Leu Asn Ala Asn Thr Ala Lys Glu Asn Gly Gly Gly Ala Asn

675 680 685Val Pro Glu Asn Ile Val Leu Thr Phe Thr Tyr Thr Pro Thr Pro Asn

690 695 700Glu Pro Ala Pro Val Gln Gln Pro Val Tyr Gly Glu Ala Leu Val Thr705 710 715 720Gly Asn Thr Ala Thr Lys Ser Gly Gly Gly Ile Tyr Thr Lys Asn Ala

725 730 735Ala Phe Ser Asn Leu Ser Ser Val Thr Phe Asp Gln Asn Thr Ser Ser

740 745 750Glu Asn Gly Gly Ala Leu Leu Thr Gln Lys Ala Ala Asp Lys Thr Asp

755 760 765Cys Ser Phe Thr Tyr Ile Thr Asn Val Asn Ile Thr Asn Asn Thr Ala

770 775 780Thr Gly Asn Gly Gly Gly Ile Ala Gly Gly Lys Ala His Phe Asp Arg785 790 795 800Ile Asp Asn Leu Thr Val Gln Ser Asn Gln Ala Lys Lys Gly Gly Gly

805 810 815Val Tyr Leu Glu Asp Ala Leu Ile Leu Glu Lys Val Ile Thr Gly Ser

820 825 830Val Ser Gln Asn Thr Ala Thr Glu Ser Gly Gly Gly Ile Tyr Ala Lys

835 840 845Asp Ile Gln Leu Gln Ala Leu Pro Gly Ser Phe Thr Ile Thr Asp Asn

850 855 860Lys Val Glu Thr Ser Leu Thr Thr Ser Thr Asn Leu Tyr Gly Gly Gly865 870 875 880Ile Tyr Ser Ser Gly Ala Val Thr Leu Thr Asn Ile Ser Gly Thr Phe

885 890 895Gly Ile Thr Gly Asn Ser Val Ile Asn Thr Ala Thr Ser Gln Asp Ala

900 905 910Asp Ile Gln Gly Gly Gly Ile Tyr Ala Thr Thr Ser Leu Ser Ile Asn

915 920 925Gln Cys Asn Thr Pro Ile Leu Phe Ser Asn Asn Ser Ala Ala Thr Lys

930 935 940Lys Thr Ser Thr Thr Lys Gln Ile Ala Gly Gly Ala Ile Phe Ser Ala945 950 955 960Ala Val Thr Ile Glu Asn Asn Ser Gln Pro Ile Ile Phe Leu Asn Asn

965 970 975Ser Ala Lys Ser Glu Ala Thr Thr Ala Ala Thr Ala Gly Asn Lys Asp

980 985 990Ser Cys Gly Gly Ala Ile Ala Ala Asn Ser Val Thr Leu Thr Asn Asn

995 1000 1005Pro Glu Ile Thr Phe Lys Gly Asn Tyr Ala Glu Thr Gly Gly Ala Ile

1010 1015 1020Gly Cys Ile Asp Leu Thr Asn Gly Ser Pro Pro Arg Lys Val Ser Ile1025 1030 1035 1040Ala Asp Asn Gly Ser Val Leu Phe Gln Asp Asn Ser Ala Leu Asn Arg

1045 1050 1055Gly Gly Ala Ile Tyr Gly Glu Thr Ile Asp Ile Ser Arg Thr Gly Ala

1060 1065 1070Thr Phe Ile Gly Asn Ser Ser Lys His Asp Gly Ser Ala Ile Cys Cys

1075 1080 1085Ser Thr Ala Leu Thr Leu Ala Pro Asn Ser Gln Leu Ile Phe Glu Asn

1090 1095 1100Asn Lys Val Thr Glu Thr Thr Ala Thr Thr Lys Ala Ser Ile Asn Asn1105 1110 1115 1120Leu Gly Ala Ala Ile Tyr Gly Asn Asn Glu Thr Ser Asp Val Thr Ile

1125 1130 1135Ser Leu Ser Ala Glu Asn Gly Ser Ile Phe Phe Lys Asn Asn Leu Cys

1140 1145 1150Thr Ala Thr Asn Lys Tyr Cys Ser Ile Ala Gly Asn Val Lys Phe Thr

1155 1160 1165Ala Ile Glu Ala Ser Ala Gly Lys Ala Ile Ser Phe Tyr Asp Ala Val

1170 1175 1180Asn Val Ser Thr Lys Glu Thr Asn Ala Gln Glu Leu Lys Leu Asn Glu1185 1190 1195 1200Lys Ala Thr Ser Thr Gly Thr Ile Leu Phe Ser Gly Glu Leu His Glu

1205 1210 1215Asn Lys Ser Tyr Ile Pro Gln Lys Val Thr Phe Ala His Gly Asn Leu

1220 1225 1230Ile Leu Gly Lys Asn Ala Glu Leu Ser Val Val Ser Phe Thr Gln Ser

1235 1240 1245Pro Gly Thr Thr Ile Thr Met Gly Pro Gly Ser Val Leu Ser Asn His

1250 1255 1260Ser Lys Glu Ala Gly Gly Ile Ala Ile Asn Asn Val Ile Ile Asp Phe1265 1270 1275 1280Ser Glu Ile Val Pro Thr Lys Asp Asn Ala Thr Val Ala Pro Pro Thr

1285 1290 1295Leu Lys Leu Val Ser Arg Thr Asn Ala Asp Ser Lys Asp Lys Ile Asp

1300 1305 1310Ile Thr Gly Thr Val Thr Leu Leu Asp Pro Asn Gly Asn Leu Tyr Gln

1315 1320 1325Asn Ser Tyr Leu Gly Glu Asp Arg Asp Ile Thr Leu Phe Asn Ile Asp

1330 1335 1340Asn Ser Ala Ser Gly Ala Val Thr Ala Thr Asn Val Thr Leu Gln Gly1345 1350 1355 1360Asn Leu Gly Ala Lys Lys Gly Tyr Leu Gly Thr Trp Asn Leu Asp Pro

1365 1370 1375Asn Ser Ser Gly Ser Lys Ile Ile Leu Lys Trp Thr Phe Asp Lys Tyr

1380 1385 1390Leu Arg Trp Pro Tyr Ile Pro Arg Asp Asn His Phe Tyr Ile Asn Ser

1395 1400 1405Ile Trp Gly Ala Gln Asn Ser Leu Val Thr Val Lys Gln Gly Ile Leu

1410 1415 1420Gly Asn Met Leu Asn Asn Ala Arg Phe Glu Asp Pro Ala Phe Asn Asn1425 1430 1435 1440Phe Trp Ala Ser Ala Ile Gly Ser Phe Leu Arg Lys Glu Val Ser Arg

1445 1450 1455Asn Ser Asp Ser Phe Thr Tyr His Gly Arg Gly Tyr Thr Ala Ala Val

1460 1465 1470Asp Ala Lys Pro Arg Gln Glu Phe Ile Leu Gly Ala Ala Phe Ser Gln

1475 1480 1485Val Phe Gly His Ala Glu Ser Glu Tyr His Leu Asp Asn Tyr Lys His

1490 1495 1500Lys Gly Ser Gly His Ser Thr Gln Ala Ser Leu Tyr Ala Gly Asn Ile1505 1510 1515 1520Phe Tyr Phe Pro Ala Ile Arg Ser Arg Pro Ile Leu Phe Gln Gly Val

1525 1530 1535Ala Thr Tyr Gly Tyr Met Gln His Asp Thr Thr Thr Tyr Tyr Pro Ser

1540 1545 1550Ile Glu Glu Lys Asn Met Ala Asn Trp Asp Ser Ile Ala Trp Leu Phe

1555 1560 1565Asp Leu Arg Phe Ser Val Asp Leu Lys Glu Pro Gln Pro His Ser Thr

1570 1575 1580Ala Arg Leu Thr Phe Tyr Thr Glu Ala Glu Tyr Thr Arg Ile Arg Gln1585 1590 1595 1600Glu Lys Phe Thr Glu Leu Asp Tyr Asp Pro Arg Ser Phe Ser Ala Cys

1605 1610 1615Ser Tyr Gly Asn Leu Ala Ile Pro Thr Gly Phe Ser Val Asp Gly Ala

1620 1625 1630Leu Ala Trp Arg Glu Ile Ile Leu Tyr Asn Lys Val Ser Ala Ala Tyr

1635 1640 1645Leu Pro Val Ile Leu Arg Asn Asn Pro Lys Ala Thr Tyr Glu Val Leu

1650 1655 1660Ser Thr Lys Glu Lys Gly Asn Val Val Asn Val Leu Pro Thr Arg Asn1665 1670 1675 1680Ala Ala Arg Ala Glu Val Ser Ser Gln Ile Tyr Leu Gly Ser Tyr Trp

1685 1690 1695Thr Leu Tyr Gly Thr Tyr Thr Ile Asp Ala Ser Met Asn Thr Leu Val

1700 1705 1710Gln Met Ala Asn Gly Gly Ile Arg Phe Val Phe

1715 1720<210>395<211>1723<212>PRT<213>肺炎衣原体<400>395Met Lys Trp Leu Pro Ala Thr Ala Val Phe Ala Ala Val Leu Pro Ala1 5 10 15Leu Thr Ala Phe Gly Asp Pro Ala Ser Val Glu Ile Ser Thr Ser His

20 25 30Thr Gly Ser Gly Asp Pro Thr Ser Asp Ala Ala Leu Thr Gly Phe Thr

35 40 45Gln Ser Ser Thr Glu Thr Asp Gly Thr Thr Tyr Thr Ile Val Gly Asp

85 90 95Ser Gly Ala Thr Ser Leu Ile Arg Ser Ser Asn Leu His Ser Asp Phe

100 105 110Asp Phe Thr Lys Asp Ser Val Leu Asp Leu Tyr His Leu Phe Phe Pro

115 120 125Ser Ala Ser Asn Thr Leu Asn Pro Ala Leu Leu Ser Ser Ser Ser Ser

165 170 175Glu Ala Asn Gly Thr Leu Thr Phe Thr Thr Asp Ser Gly Asn Pro Gly

180 185 190Ser Leu Thr Leu Gln Asn Leu Lys Met Thr Gly Asp Gly Ala Ala Ile

195 200 205Tyr Ser Lys Gly Pro Leu Val Phe Thr Gly Leu Lys Asn Leu Thr Phe

245 250 255Thr Ser Ala Gly Gln Gly Gly Ala Ile Tyr Val Lys Glu Ala Thr Leu

260 265 270Phe Asn Ala Leu Asp Ser Leu Lys Phe Glu Lys Asn Thr Ser Gly Gln

275 280 285Ala Gly Gly Gly Ile Tyr Thr Glu Ser Thr Leu Thr Ile Ser Asn Ile

325 330 335Thr Ile Asp Thr Ser Thr Leu Gln Thr Arg Ala Ala Ser Ala Thr Pro

340 345 350Ala Val Ala Pro Val Ala Ala Val Thr Pro Thr Pro Ile Ser Thr Gln

355 360 365Glu Thr Ala Gly Asn Gly Gly Ala Ile Tyr Ala Lys Gln Gly Ile Ser

405 410 415Ala Ile Phe Ala Ala Asp Ser Ile Gln Ile Gln Gln Cys Thr Gly Thr

420 425 430Thr Leu Phe Ser Gly Asn Thr Ala Asn Lys Ser Gly Gly Gly Ile Tyr

435 440 445Ala Val Gly Gln Val Thr Leu Glu Asp Ile Ala Asn Leu Lys Met Thr

485 490 495Ser Thr Asp Asn Gly Gly Ala Ile Phe Ala Val Gly Gly Ile Thr Leu

500 505 510Ser Asp Leu Val Glu Val Arg Phe Ser Lys Asn Lys Thr Gly Asn Tyr

515 520 525Ser Ala ProIle Thr Lys Ala Ala Ser Asn Thr Ala Pro Val Val Ser

565 570 575Leu Thr Val Ser Gly Ile Thr Ser Ile Leu Ser Phe Glu Asn Asn Glu

580 585 590Cys Gln Asn Gln Gly Gly Gly Ala Tyr Val Thr Lys Thr Phe Gln Cys

595 600 605Ser Asp Ser His Arg Leu Gln Phe Thr Ser Asn Lys Ala Ala Asp Glu

645 650 655Leu Ser Leu Ala Ser Gly Lys Ser Leu Thr Met Thr Ser Leu Glu Ser

660 665 670Phe Cys Leu Asn Ala Asn Thr Ala Lys Glu Asn Gly Gly Gly Ala Asn

675 680 685Val Pro Glu Asn Ile Val Leu Thr Phe Thr Tyr Thr Pro Thr Pro Asn

725 730 735Ala Phe Ser Asn Leu Ser Ser Val Thr Phe Asp Gln Asn Thr Ser Ser

740 745 750Glu Asn Gly Gly Ala Leu Leu Thr Gln Lys Ala Ala Asp Lys Thr Asp

755 760 765Cys Ser Phe Thr Tyr Ile Thr Asn Val Asn Ile Thr Asn Asn Thr Ala

805 810 815Val Tyr Leu Glu Asp Ala Leu Ile Leu Glu Lys Val Ile Thr Gly Ser

820 825 830Val Ser Gln Asn Thr Ala Thr Glu Ser Gly Gly Gly Ile Tyr Ala Lys

835 840 845Asp Ile Gln Leu Gln Ala Leu Pro Gly Ser Phe Thr Ile Thr Asp Asn

885 890 895Gly Ile Thr Gly Asn Ser Val Ile Asn Thr Ala Thr Ser Gln Asp Ala

900 905 910Asp Ile Gln Gly Gly Gly Ile Tyr Ala Thr Thr Ser Leu Ser Ile Asn

915 920 925Gln Cys Asn Thr Pro Ile Leu Phe Ser Asn Asn Ser Ala Ala Thr Lys

965 970 975Ser Ala Lys Ser Glu Ala Thr Thr Ala Ala Thr Ala Gly Asn Lys Asp

980 985 990Ser Cys Gly Gly Ala Ile Ala Ala Asn Ser Val Thr Leu Thr Asn Asn

995 1000 1005Pro Glu Ile Thr Phe Lys Gly Asn Tyr Ala Glu Thr Gly Gly Ala Ile

1045 1050 1055Gly Gly Ala Ile Tyr Gly Glu Thr Ile Asp Ile Ser Arg Thr Gly Ala

1060 1065 1070Thr Phe Ile Gly Asn Ser Ser Lys His Asp Gly Ser Ala Ile Cys Cys

1075 1080 1085Ser Thr Ala Leu Thr Leu Ala Pro Asn Ser Gln Leu Ile Phe Glu Asn

1090 1095 1100Asn Lys Val Thr Glu Thr Thr Ala Thr Thr Lys Ala Ser Ile Asn Asn1105 1110 1115 1120Leu Gly Ala Ala Ile Tyr Gly Asn Asn Glu Thr Ser Asp Ile Thr Ile

1125 1130 1135Ser Leu Ser Ala Glu Asn Gly Ser Ile Phe Phe Lys Asn Asn Leu Cys

1140 1145 1150Thr Ala Thr Asn Lys Tyr Cys Ser Ile Ala Gly Asn Val Lys Phe Thr

1155 1160 1165Ala Ile Glu Ala Ser Ala Gly Lys Ala Ile Ser Phe Tyr Asp Ala Val

1205 1210 1215Asn Lys Ser Tyr Ile Pro Gln Lys Val Thr Phe Ala His Gly Asn Leu

1220 1225 1230Ile Leu Gly Lys Asn Ala Glu Leu Ser Val Val Ser Phe Thr Gln Ser

1235 1240 1245Pro Gly Thr Thr Ile Thr Met Gly Pro Gly Ser Val Leu Ser Asn His

1285 1290 1295Leu Lys Leu Val Ser Arg Thr Asn Ala Asp Ser Lys Asp Lys Ile Asp

1300 1305 1310Ile Thr Gly Thr Val Thr Leu Leu Asp Pro Asn Gly Asn Leu Tyr Gln

1315 1320 1325Asn Ser Tyr Leu Gly Glu Asp Arg Asp Ile Thr Leu Phe Asn Ile Asp

1365 1370 1375Asn Ser Ser Gly Ser Lys Ile Ile Leu Lys Trp Thr Phe Asp Lys Tyr

1380 1385 1390Leu Arg Trp Pro Tyr Ile Pro Arg Asp Asn His Phe Tyr Ile Asn Ser

1395 1400 1405Ile Trp Gly Ala Gln Asn Ser Leu Val Thr Val Lys Gln Gly Ile Leu

1445 1450 1455Asn Ser Asp Ser Phe Thr Tyr His Gly Arg Gly Tyr Thr Ala Ala Val

1460 1465 1470Asp Ala Lys Pro Arg Gln Glu Phe Ile Leu Gly Ala Ala Phe Ser Gln

1475 1480 1485Val Phe Gly His Ala Glu Ser Glu Tyr His Leu Asp Asn Tyr Lys His

1525 1530 1535Ala Thr Tyr Gly Tyr Met Gln His Asp Thr Thr Thr Tyr Tyr Pro Ser

1540 1545 1550Ile Glu Glu Lys Asn Met Ala Asn Trp Asp Ser Ile Ala Trp Leu Phe

1555 1560 1565Asp Leu Arg Phe Ser Val Asp Leu Lys Glu Pro Gln Pro His Ser Thr

1605 1610 1615Ser Tyr Gly Asn Leu Ala Ile Pro Thr Gly Phe Ser Val Asp Gly Ala

1620 1625 1630Leu Ala Trp Arg Glu Ile Ile Leu Tyr Asn Lys Val Ser Ala Ala Tyr

1635 1640 1645Leu Pro Val Ile Leu Arg Asn Asn Pro Lys Ala Thr Tyr Glu Val Leu

1685 1690 1695Thr Leu Tyr Gly Thr Tyr Thr Ile Asp Ala Ser Met Asn Thr Leu Val

1700 1705 1710Gln Met Ala Asn Gly Gly Ile Arg Phe Val Phe

1715 1720<210>396<211>1252<212>PRT<213>肺炎衣原体<400>396Met Leu Lys Cys Pro Glu Arg Val Ser Val Lys Lys Lys Glu Asp Ile

5 10 15Pro Asp Leu Pro Asn Leu Ile Glu Ile Gln Ile Lys Ser Tyr Lys Gln

20 25 30Phe Leu Gln Ile Gly Lys Leu Ala Glu Glu Arg Glu Asn Ile Gly Leu

35 40 45Glu Glu Val Phe Arg Glu Ile Phe Pro Ile Lys Ser Tyr Asn Glu Ala

50 55 60Thr Val Leu Glu Tyr Leu Ser Tyr Asn Leu Gly Val Pro Lys Tyr Ser65 70 75 80Pro Glu Glu Cys Ile Arg Arg Gly Ile Thr Tyr Ser Val Thr Leu Lys

85 90 95Val Arg Phe Arg Leu Thr Asp Glu Thr Gly Ile Lys Glu Glu Glu Val

100 105 110Tyr Met Gly Thr Ile Pro Leu Met Thr Asp Lys Gly Thr Phe Ile Ile

115 120 125Asn Gly Ala Glu Arg Val Val Val Ser Gln Val His Arg Ser Pro Gly

130 135 140Ile Asn Phe Glu Gln Glu Lys His Ser Lys Gly Asn Ile Leu Phe Ser145 150 155 160Phe Arg Ile Ile Pro Tyr Arg Gly Ser Trp Leu Glu Ala Ile Phe Asp

165 170 175Ile Asn Asp Leu Ile Tyr Ile His Ile Asp Arg Lys Lys Arg Arg Arg

180 185 190Lys Ile Leu Ala Ile Thr Phe Ile Arg Ala Leu Gly Tyr Ser Ser Asp

195 200 205Ala Asp Ile Ile Glu Glu Phe Phe Thr Ile Gly Glu Ser Ser Leu Arg

210 215 220Ser Glu Lys Asp Phe Ala Leu Leu Val Gly Arg Ile Leu Ala Asp Asn225 230 235 240Ile Ile Asp Glu Ala Ser Ser Leu Val Tyr Gly Lys Ala Gly Glu Lys

245 250 255Leu Ser Thr Ala Met Leu Lys Arg Met Leu Asp Ala Gly Ile Ala Ser

260 265 270Val Lys Ile Ala Val Asp Ala Asp Glu Asn His Pro Ile Ile Lys Met

275 280 285Leu Ala Lys Asp Pro Thr Asp Ser Tyr Glu Ala Ala Leu Lys Asp Phe

290 295 300Tyr Arg Arg Leu Arg Pro Gly Glu Pro Ala Thr Leu Ala Asn Ala Arg305 310 315 320Ser Thr Ile Met Arg Leu Phe Phe Asp Pro Lys Arg Tyr Asn Leu Gly

325 330 335Arg Val Gly Arg Tyr Lys Leu Asn Arg Lys Leu Gly Phe Ser Ile Asp

340 345 350Asp Glu Ala Leu Ser Gln Val Thr Leu Arg Lys Glu Asp Val Ile Gly

355 360 365Ala Leu Lys Tyr Leu Ile Arg Lei Lys Met Gly Asp Glu Lys Ala Cys

370 375 380Val Asp Asp Ile Asp His Leu Ala Asn Arg Arg Val Arg Ser Val Gly385 390 395 400Glu Leu Ile Gln Asn Gln Cys Arg Ser Gly Leu Ala Arg Met Glu Lys

405 410 415Ile Val Arg Glu Arg Met Asn Leu Phe Asp Phe Ser Ser Asp Thr Leu

420 425 430Thr Pro Gly Lys Val Val Ser Ala Lys Gly Leu Ala Ser Val Leu Lys

435 440 445Asp Phe Phe Gly Arg Ser Gln Leu Ser Gln Phe Met Asp Gln Thr Asn

450 455 460Pro Val Ala Glu Leu Thr His Lys Arg Arg Leu Ser Ala Leu Gly Pro465 470 475 480Gly Gly Leu Asn Arg Glu Arg Ala Gly Phe Glu Val Arg Asp Val His

485 490 495Ala Ser His Tyr Gly Arg Ile Cys Pro Ile Glu Thr Pro Glu Gly Pro

500 505 510Asn Ile Gly Leu Ile Thr Ser Leu Ser Ser Phe Ala Lys Ile Asn Glu

515 520 525Phe Gly Phe Ile Glu Thr Pro Tyr Arg Ile Val Arg Asp Gly Ile Val

530 535 540Thr Asp Glu Ile Glu Tyr Met Thr Ala Asp Val Glu Glu Glu Cys Val545 550 555 560Ile Ala Gln Ala Ser Ala Ser Leu Asp Glu Tyr Asn Met Phe Thr Glu

565 570 575Pro Val Cys Trp Val Arg Tyr Ala Gly Glu Ala Phe Glu Ala Asp Thr

580 585 590Ser Thr Val Thr His Met Asp Val Ser Pro Lys Gln Leu Val Ser Ile

595 600 605Val Thr Gly Leu Ile Pro Phe Leu Glu His Asp Asp Ala Asn Arg Ala

610 615 620Leu Met Gly Ser Asn Met Gln Arg Gln Ala Val Pro Leu Leu Lys Thr625 630 635 640Glu Ala Pro Val Val Gly Thr Gly Leu Glu Cys Arg Ala Ala Lys Asp

645 650 655Ser Gly Ala Ile Val Val Ala Glu Glu Asp Gly Val Val Asp Phe Val

660 665 670Asp Gly Tyr Lys Val Val Val Ala Ala Lys His Asn Pro Thr Ile Lys

675 680 685Arg Thr Tyr His Leu Lys Lys Phe Leu Arg Ser Asn Ser Gly Thr Cys

690 695 700Ile Asn Gln Gln Pro Leu Cys Ala Val Gly Asp Val Ile Thr Lys Gly705 710 715 720Asp Val Ile Ala Asp Gly Pro Ala Thr Asp Arg Gly Glu Leu Ala Leu

725 730 735Gly Lys Asn Val Leu Val Ala Phe Met Pro Trp Tyr Gly Tyr Asn Phe

740 745 750Glu Asp Ala Ile Ile Ile Ser Glu Lys Leu Ile Arg Glu Asp Ala Tyr

755 760 765Thr Ser Ile Tyr Ile Glu Glu Phe Glu Leu Thr Ala Arg Asp Thr Lys

770 775 780Leu Gly Lys Glu Glu Ile Thr Arg Asp Ile Pro Asn Val Ser Asp Glu785 790 795 800Val Leu Ala Asn Leu Gly Glu Asp Gly Ile Ile Arg Ile Gly Ala Glu

805 810 815Val Lys Pro Gly Asp Ile Leu Val Gly Lys Ile Thr Pro Lys Ser Glu

820 825 830Thr Glu Leu Ala Pro Glu Glu Arg Leu Leu Arg Ala Ile Phe Gly Glu

835 840 845Lys Ala Ala Asp Val Lys Asp Ala Ser Leu Thr Val Pro Pro Gly Thr

850 855 860Glu Gly Val Val Met Asp Val Lys Val Phe Ser Arg Lys Asp Arg Leu865 870 875 880Ser Lys Ser Asp Asp Glu Leu Val Glu Glu Ala Val His Leu Lys Asp

885 890 895Leu Gln Lys Gly Tyr Lys Asn Gln Val Ala Thr Leu Lys Thr Glu Tyr

900 905 910Arg Glu Lys Leu Gly Ala Leu Leu Leu Asn Glu Lys Ala Pro Ala Ala

915 920 925Ile Ile His Arg Arg Thr Ala Glu Ile Val Val His Glu Gly Leu Leu

930 935 940Phe Asp Gln Glu Thr Ile Glu Arg Ile Glu Gln Glu Asp Leu Val Asp945 950 955 960Leu Leu Met Pro Asn Cys Glu Met Tyr Glu Val Leu Lys Gly Leu Leu

965 970 975Ser Asp Tyr Glu Thr Ala Leu Gln Arg Leu Glu Ile Asn Tyr Lys Thr

980 985 990Glu Val Glu His Ile Arg Glu Gly Asp Ala Asp Leu Asp His Gly Val

995 1000 1005Ile Arg Gln Val Lys Val Tyr Val Ala Ser Lys Arg Lys Leu Gln Val

1010 1015 1020Gly Asp Lys Met Ala Gly Arg His Gly Asn Lys Gly Val Val Ser Lys1025 1030 1035 1040Ile Val Pro Glu Ala Asp Met Pro Tyr Leu Ser Asn Gly Glu Thr Val

1045 1050 1055Gln Met Ile Leu Asn Pro Leu Gly Val Pro Ser Arg Met Asn Leu Gly

1060 1065 1070Gln Val Leu Glu Thr His Leu Gly Tyr Ala Ala Lys Thr Ala Gly Ile

1075 1080 1085Tyr Val Lys Thr Pro Val Phe Glu Gly Phe Pro Glu Gln Arg Ile Trp

1090 1095 1100Asp Met Met Ile Glu Gln Gly Leu Pro Glu Asp Gly Lys Ser Phe Leu1105 1110 1115 1120Tyr Asp Gly Lys Thr Gly Glu Arg Phe Asp Asn Lys Val Val Ile Gly

1125 1130 1135Tyr Ile Tyr Met Leu Lys Leu Ser His Leu Ile Ala Asp Lys Ile His

1140 1145 1150Ala Arg Ser Ile Gly Pro Tyr Ser Leu Val Thr Gln Gln Pro Leu Gly

1155 1160 1165Gly Lys Ala Gln Met Gly Gly Gln Arg Phe Gly Glu Met Glu Val Trp

1170 1175 1180Ala Leu Glu Ala Tyr Gly Val Ala His Met Leu Gln Glu Ile Leu Thr1185 1190 1195 1200Val Lys Ser Asp Asp Val Ser Gly Arg Thr Arg Ile Tyr Glu Ser Ile

1205 1210 1215Val Lys Gly Glu Asn Leu Leu Arg Ser Gly Thr Pro Glu Ser Phe Asn

1220 1225 1230Val Leu Ile Lys Glu Met Gln Gly Leu Gly Leu Asp Val Arg Pro Met

1235 1240 1245Val Val Asp Ala

1250<210>397<211>224<212>PRT<213>肺炎衣原体<400>397Met Thr Ser Trp Ile Glu Leu Leu Asp Lys Gln Ile Glu Asp Gln His

5 10 15Met Leu Lys His Glu Phe Tyr Gln Arg Trp Ser Glu Gly Lys Leu Glu

20 25 30Lys Gln Gln Leu Gln Ala Tyr Ala Lys Asp Tyr Tyr Leu His Ile Lys

35 40 45Ala Phe Pro Cys Tyr Leu Ser Ala Leu His Ala Arg Cys Asp Asp Leu

50 55 60Gln Ile Arg Arg Gln Ile Leu Glu Asn Leu Met Asp Glu Glu Ala Gly65 70 75 80Asn Pro Asn His Ile Asp Leu Trp Arg Gln Phe Ala Leu Ser Leu Gly

85 90 95Val Ser Glu Glu Glu Leu Ala Asn His Glu Phe Ser Gln Ala Ala Gln

100 105 110Asp Met Val Ala Thr Phe Arg Arg Leu Cys Asp Met Pro Gln Leu Ala

115 120 125Val Gly Leu Gly Ala Leu Tyr Thr Tyr Glu Ile Gln Ile Pro Gln Val

130 135 140Cys Val Glu Lys Ile Arg Gly Leu Lys Glu Tyr Phe Gly Val Ser Ala145 150 155 160Arg Gly Tyr Ala Tyr Phe Thr Val His Gln Glu Ala Asp Ile Lys His

165 170 175Ala Ser Glu Glu Lys Glu Met Leu Gln Thr Leu Val Gly Arg Glu Asn

180 185 190Pro Asp Ala Val Leu Gln Gly Ser Gln Glu Val Leu Asp Thr Leu Trp

195 200 205Asn Phe Leu Ser Ser Phe Ile Asn Ser Thr Glu Pro Cys Ser Cys Lys

210 215 220<210>398<211>556<212>PRT<213>肺炎衣原体<400>398Met Ser Lys Leu Ile Arg Arg Val Val Thr Val Leu Ala Leu Thr Ser

5 10 15Met Ala Ser Cys Phe Ala Ser Gly Gly Ile Glu Ala Ala Val Ala Glu

20 25 30Ser Leu Ile Thr Lys Ile Val Ala Ser Ala Glu Thr Lys Pro Ala Pro

35 40 45Val Pro Met Thr Ala Lys Lys Val Arg Leu Val Arg Arg Asn Lys Gln

50 55 60Pro Val Glu Gln Lys Ser Arg Gly Ala Phe Cys Asp Lys Glu Phe Tyr65 70 75 80Pro Cys Glu Glu Gly Arg Cys Gln Pro Val Glu Ala Gln Gln Glu Ser

85 90 95Cys Tyr Gly Arg Leu Tyr Ser Val Lys Val Asn Asp Asp Cys Asr Val

100 105 110Glu Ile Cys Gln Ser Val Pro Glu Tyr Ala Thr Val Gly Ser Pro Tyr

115 120 125Pro Ile Glu Ile Leu Ala Ile Gly Lys Lys Asp Cys Val Asp Val Val

130 135 140Ile Thr Gln Gln Leu Pro Cys Glu Ala Glu Phe Val Ser Ser Asp Pro145 150 155 160Glu Thr Thr Pro Thr Ser Asp Gly Lys Leu Val Trp Lys Ile Asp Arg

165 170 175Leu Gly Ala Gly Asp Lys Cys Lys Ile Thr Val Trp Val Lys Pro Leu

180 185 190Lys Glu Gly Cys Cys Phe Thr Ala Ala Thr Val Cys Ala Cys Pro Glu

195 200 205Leu Arg Ser Tyr Thr Lys Cys Gly Gln Pro Ala Ile Cys Ile Lys Gln

210 215 220Glu Gly Pro Asp Cys Ala Cys Leu Arg Cys Pro Val Cys Tyr Lys Ile225 230 235 240Glu Val Val Asn Thr Gly Ser Ala Ile Ala Arg Asn Val Thr Val Asp

245 250 255Asn Pro Val Pro Asp Gly Tyr Ser His Ala Ser Gly Gln Arg Val Leu

260 265 270Ser Phe Asn Leu Gly Asp Met Arg Pro Gly Asp Lys Lys Val Phe Thr

275 280 285Val Glu Phe Cys Pro Gln Arg Arg Gly Gln Ile Thr Asn Val Ala Thr

290 295 300Val Thr Tyr Cys Gly Gly His Lys Cys Ser Ala Asn Val Thr Thr Val305 310 315 320Val Asn Glu Pro Cys Val Gln Val Asn Ile Ser Gly Ala Asp Trp Ser

325 330 335Tyr Val Cys Lys Pro Val Glu Tyr Ser Ile Ser Val Ser Asn Pro Gly

340 345 350Asp Leu Val Leu His Asp Val Val Ile Gln Asp Thr Leu Pro Ser Gly

355 360 365Val Thr Val Leu Glu Ala Pro Gly Gly Glu Ile Cys Cys Asn Lys Val

370 375 380Val Trp Arg Ile Lys Glu Met Cys Pro Gly Glu Thr Leu Gln Phe Lys385 390 395 400Leu Val Val Lys Ala Gln Val Pro Gly Arg Phe Thr Asn Gln Val Ala

405 410 415Val Thr Ser Glu Ser Asn Cys Gly Thr Cys Thr Ser Cys Ala Glu Thr

420 425 430Thr Thr His Trp Lys Gly Leu Ala Ala Thr His Met Cys Val Leu Asp

435 440 445Thr Asn Asp Pro Ile Cys Val Gly Glu Asn Thr Val Tyr Arg Ile Cys

450 455 460Val Thr Asn Arg Gly Ser Ala Glu Asp Thr Asn Val Ser Leu Ile Leu465 470 475 480Lys Phe Ser Lys Glu Leu Gln Pro Ile Ala Ser Ser Gly Pro Thr Lys

485 490 495Gly Thr Ile Ser Gly Asn Thr Val Val Phe Asp Ala Leu Pro Lys Leu

500 505 510Gly Ser Lys Glu Ser Val Glu Phe Ser Val Thr Leu Lys Gly Ile Ala

515 520 525Pro Gly Asp Ala Arg Gly Glu Ala Ile Leu Ser Ser Asp Thr Leu Thr

530 535 540Ser Pro Val Ser Asp Thr Glu Asn Thr His Val Tyr545 550 555<210>399<211>461<212>PRT<213>肺炎衣原体<400>399Met Thr Gln Glu Phe Asp Cys Val Val Ile Gly Ala Gly Pro Ser Gly

5 10 15Tyr Val Ala Ala Ile Thr Ala Ala Gln Ser Lys Leu Arg Thr Ala Leu

20 25 30Ile Glu Glu Asp Gln Ala Gly Gly Thr Cys Leu Asn Arg Gly Cys Ile

35 40 45Pro Ser Lys Ala Leu Ile Ala Gly Ala Asn Val Val Ser His Ile Lys

50 55 60His Ala Glu Gln Phe Gly Ile His Val Asp Gly Tyr Thr Ile Asp Tyr65 70 75 80Pro Ala Met Ala Lys Arg Lys Asn Thr Val Val Gln Gly Ile Arg Gln

85 90 95Gly Leu Glu Gly Leu Ile Arg Ser Asn Lys Ile Thr Val Leu Lys Gly

100 105 110Thr Gly Ser Leu Val Ser Ser Thr Glu Val Lys Val Ile Gly Gln Asp

115 120 125Thr Thr Ile Ile Lys Ala Asn His Ile Ile Leu Ala Thr Gly Ser Glu

130 135 140Pro Arg Pro Phe Pro Gly Val Pro Phe Ser Ser Arg Ile Leu Ser Ser145 150 155 160Thr Gly Ile Leu Glu Leu Glu Val Leu Pro Lys Lys Leu Ala Ile Ile

165 170 175Gly Gly Gly Val Ile Gly Cys Glu Phe Ala Ser Leu Phe His Thr Leu

180 185 190Gly Val Glu Ile Thr Val Ile Glu Ala Leu Asp His Ile Leu Ala Val

195 200 205Asn Asn Lys Glu Val Ser Gln Thr Val Thr Asn Lys Phe Thr Lys Gln

210 215 220Gly Ile Arg Ile Leu Thr Lys Ala Ser Ile Ser Ala Ile Glu Glu Ser225 230 235 240Gln Asn Gln Val Arg Ile Thr Val Asn Asp Gln Val Glu Glu Phe Asp

245 250 255Tyr Val Leu Val Ala Ile Gly Arg Gln Phe Asn Thr Ala Ser Ile Gly

260 265 270Leu Asp Asn Ala Gly Val Ile Arg Asp Asp Arg Gly Val Ile Pro Val

275 280 285Asp Glu Thr Met Arg Thr Asn Val Pro Asn Ile Tyr Ala Ile Gly Asp

290 295 300Ile Thr Gly Lys Trp Leu Leu Ala His Val Ala Ser His Gln Gly Val305 310 315 320Ile Ala Ala Lys Asn Ile Ser Gly His His Glu Val Met Asp Tyr Ser

325 330 335Ala Ile Pro Ser Val Ile Phe Thr His Pro Glu Ile Ala Met Val Gly

340 345 350Leu Ser Leu Gln Glu Ala Glu Gln Gln Asn Leu Pro Ala Lys Leu Thr

355 360 365Lys Phe Pro Phe Lys Ala Ile Gly Lys Ala Val Ala Leu Gly Ala Ser

370 375 380Asp Gly Phe Ala Ala Ile Val Ser His Glu Ile Thr Gln Gln Ile Leu385 390 395 400Gly Ala Tyr Val Ile Gly Pro His Ala Ser Ser Leu Ile Gly Glu Met

405 410 415Thr Leu Ala Ile Arg Asn Glu Leu Thr Leu Pro Cys Ile Tyr Glu Thr

420 425 430Val His Ala His Pro Thr Leu Ser Glu Val Trp Ala Glu Gly Ala Leu

435 440 445Leu Ala Thr Asn His Pro Leu His Phe Pro Pro Lys Ser

450 455 460<210>400<211>544<212>PRT<213>肺炎衣原体<400>400Met Ala Ala Lys Asn Ile Lys Tyr Asn Glu Glu Ala Arg Lys Lys Ile

5 10 15His Lys Gly Val Lys Thr Leu Ala Glu Ala Val Lys Val Thr Leu Gly

20 25 30Pro Lys Gly Arg His Val Val Ile Asp Lys Ser Phe Gly Ser Pro Gln

35 40 45Val Thr Lys Asp Gly Val Thr Val Ala Lys Glu Ile Glu Leu Glu Asp

50 55 60Lys His Glu Asn Met Gly Ala Gln Met Val Lys Glu Val Ala Ser Lys65 70 75 80Thr Ala Asp Lys Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala

85 90 95Glu Ala Ile Tyr Ser Glu Gly Leu Arg Asn Val Thr Ala Gly Ala Asn

100 105 110Pro Met Asp Leu Lys Arg Gly Ile Asp Lys Ala Val Lys Val Val Val

115 120 125Asp Glu Leu Lys Lys Ile Ser Lys Pro Val Gln His His Lys Glu Ile

130 135 140Ala Gln Val Ala Thr Ile Ser Ala Asn Asn Asp Ser Glu Ile Gly Asn145 150 155 160Leu Ile Ala Glu Ala Met Glu Lys Val Gly Lys Asn Gly Ser Ile Thr

165 170 175Val Glu Glu Ala Lys Gly Phe Glu Thr Val Leu Asp Val Val Glu Gly

180 185 190Met Asn Phe Asn Arg Gly Tyr Leu Ser Ser Tyr Phe Ser Thr Asn Pro

195 200 205Glu Thr Gln Glu Cys Val Leu Glu Asp Ala Leu Ile Leu Ile Tyr Asp

210 215 220Lys Lys Ile Ser Gly Ile Lys Asp Phe Leu Pro Val Leu Gln Gln Val225 230 235 240Ala Glu Ser Gly Arg Pro Leu Leu Ile Ile Ala Glu Glu Ile Glu Gly

245 250 255Glu Ala Leu Ala Thr Leu Val Val Asn Arg Leu Arg Ala Gly Phe Arg

260 265 270Val Cys Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met

275 280 285Leu Glu Asp Ile Ala Ile Leu Thr Gly Gly Gln Leu Val Ser Glu Glu

290 295 300Leu Gly Met Lys Leu Glu Asn Thr Thr Leu Ala Met Leu Gly Lys Ala305 310 315 320Lys Lys Val Ile Val Thr Lys Glu Asp Thr Thr Ile Val Glu Gly Leu

325 330 335Gly Asn Lys Pro Asp Ile Gln Ala Arg Cys Asp Asn Ile Lys Lys Gln

340 345 350Ile Glu Asp Ser Thr Ser Asp Tyr Asp Lys Glu Lys Leu Gln Glu Arg

355 360 365Leu Ala Lys Leu Ser Gly Gly Val Ala Val Ile Arg Val Gly Ala Ala

370 375 380Thr Glu Ile Glu Met Lys Glu Lys Lys Asp Arg Val Asp Asp Ala Gln385 390 395 400His Ala Thr Ile Ala Ala Val Glu Glu Gly Ile Leu Pro Gly Gly Gly

405 410 415Thr Ala Leu Val Arg Cys Ile Pro Thr Leu Glu Ala Phe Leu Pro Met

420 425 430Leu Ala Asn Glu Asp Glu Ala Ile Gly Thr Arg Ile Ile Leu Lys Ala

435 440 445Leu Thr Ala Pro Leu Lys Gln Ile Ala Ser Asn Ala Gly Lys Glu Gly

450 455 460Ala Ile Ile Cys Gln Gln Val Leu Ala Arg Ser Ala Asn Glu Gly Tyr465 470 475 480Asp Ala Leu Arg Asp Ala Tyr Thr Asp Met Ile Asp Ala Gly Ile Leu

485 490 495Asp Pro Thr Lys Val Thr Arg Ser Ala Leu Glu Ser Ala Ala Ser Ile

500 505 510Ala Gly Leu Leu Leu Thr Thr Glu Ala Leu Ile Ala Asp Ile Pro Glu

515 520 525Glu Lys Ser Ser Ser Ala Pro Ala Met Pro Ser Ala Gly Met Asp Tyr

530 535 540<210>401<211>664<212>PRT<213>肺炎衣原体<400>401Met Glu Lys Val Ser Ser Tyr Pro Ser Val Pro Leu Pro Leu Gly Ala

5 10 15Ser Lys Ile Ser Pro Asn Arg Tyr Arg Phe Ala Leu Tyr Ala Ser Gln

20 25 30Ala Thr Glu Val Ile Leu Ala Leu Thr Asp Glu Asn Ser Glu Val Ile

35 40 45Glu Val Pro Leu Tyr Pro Asp Thr His Arg Thr Gly Ala Ile Trp His

50 55 60Ile Glu Ile Glu Gly Ile Ser Asp Gln Ser Ser Tyr Ala Phe Arg Val65 70 75 80His Gly Pro Lys Lys His Gly Met Gln Tyr Ser Phe Lys Glu Tyr Leu

85 90 95Ala Asp Pro Tyr Ala Lys Asn Ile His Ser Pro Gln Ser Phe Gly Ser

100 105 110Arg Lys Lys Gln Gly Asp Tyr Ala Phe Cys Tyr Leu Lys Glu Glu Pro

115 120 125Phe Pro Trp Asp Gly Asp Gln Pro Leu His Leu Pro Lys Glu Glu Met

130 135 140Ile Ile Tyr Glu Met His Val Arg Ser Phe Thr Gln Ser Ser Ser Ser145 150 155 160Arg Val His Ala Pro Gly Thr Phe Leu Gly Ile Ile Glu Lys Ile Asp

165 170 175His Leu His Lys Leu Gly Ile Asn Ala Val Glu Leu Leu Pro Ile Phe

180 185 190Glu Phe Asp Glu Thr Ala His Pro Phe Arg Asn Ser Lys Phe Pro Tyr

195 200 205Leu Cys Asn Tyr Trp Gly Tyr Ala Pro Leu Asn Phe Phe Ser Pro Cys

210 215 220Arg Arg Tyr Ala Tyr Ala Ser Asp Pro Cys Ala Pro Ser Arg Glu Phe225 230 235 240Lys Thr Leu Val Lys Thr Leu His Gln Glu Gly Ile Glu Val Ile Leu

245 250 255Asp Val Val Phe Asn His Thr Gly Leu Gln Gly Thr Thr Cys Ser Leu

260 265 270Pro Trp Ile Asp Thr Pro Ser Tyr Tyr Ile Leu Asp Ala Gln Gly His

275 280 285Phe Thr Asn Tyr Ser Gly Cys Gly Asn Thr Leu Asn Thr Asn Arg Ala

290 295 300Pro Thr Thr Gln Trp Ile Leu Asp Ile Leu Arg Tyr Trp Val Glu Glu305 310 315 320Met His Val Asp Gly Phe Arg Phe Asp Leu Ala Ser Val Phe Ser Arg

325 330 335Gly Pro Ser Gly Ser Pro Leu Gln Phe Ala Pro Val Leu Glu Ala Ile

340 345 350Ser Phe Asp Pro Leu Leu Ala Ser Thr Lys Ile Ile Ala Glu Pro Trp

355 360 365Asp Ala Gly Gly Leu Tyr Gln Val Gly Tyr Phe Pro Thr Leu Ser Pro

370 375 380Arg Trp Ser Glu Trp Asn Gly Pro Tyr Arg Asp Asn Val Lys Ala Phe385 390 395 400Leu Asn Gly Asp Gln Asn Leu Ile Gly Thr Phe Ala Ser Arg Ile Ser

405 410 415Gly Ser Gln Asp Ile Tyr Pro His Gly Ser Pro Thr Asn Ser Ile Asn

420 425 430Tyr Val Ser Cys His Asp Gly Phe Thr Leu Cys Asp Thr Val Thr Tyr

435 440 445Asn His Lys His Asn Glu Ala Asn Gly Glu Asp Asn Arg Asp Gly Thr

450 455 460Asp Ala Asn Tyr Ser Tyr Asn Phe Gly Thr Glu Gly Lys Thr Glu Asp465 470 475 480Pro Gly Ile Leu Glu Val Arg Glu Arg Gln Leu Arg Asn Phe Phe Leu

485 490 495Thr Leu Met Val Ser Gln Gly Ile Pro Met Ile Gln Ser Gly Asp Glu

500 505 510Tyr Ala His Thr Ala Glu Gly Asn Asn Asn Arg Trp Ala Leu Asp Ser

515 520 525Asn Ala Asn Tyr Phe Leu Trp Asp Gln Leu Thr Ala Lys Pro Thr Leu

530 535 540Met His Phe Leu Cys Asp Leu Ile Ala Phe Arg Lys Lys Tyr Lys Thr545 550 555 560Leu Phe Asn Arg Gly Phe Leu Ser Asn Lys Glu Ile Ser Trp Val Asp

565 570 575Ala Met Gly Asn Pro Met Thr Trp Arg Pro Gly Asn Phe Leu Ala Phe

580 585 590Lys Ile Lys Ser Pro Lys Ala His Val Tyr Val Ala Phe His Val Gly

595 600 605Ala Gln Asp Gln Leu Ala Thr Leu Pro Lys Ala Ser Ser Asn Phe Leu

610 615 620Pro Tyr Gln Ile Val Ala Glu Ser Gln Gln Gly Phe Val Pro Gln Asn625 630 635 640Val Ala Thr Pro Thr Val Ser Leu Gln Pro His Thr Thr Leu Ile Ala

645 650 655Ile Ser His Ala Lys Glu Val Thr

660<210>402<211>328<212>PRT<213>肺炎衣原体<400>402Met Ala Phe Lys Glu Val Val Arg Val Ala Val Thr Gly Gly Lys Gly

5 10 15Gln Ile Ala Tyr Asn Phe Leu Phe Ala Leu Ala His Gly Asp Val Phe

20 25 30Gly Val Asp Arg Gly Val Asp Leu Arg Ile Tyr Asp Val Pro Gly Thr

35 40 45Glu Arg Ala Leu Ser Gly Val Arg Met Glu Leu Asp Asp Gly Ala Tyr

50 55 60Pro Leu Leu His Arg Leu Arg Val Thr Thr Ser Leu Asn Asp Ala Phe65 70 75 80Asp Gly Ile Asp Ala Ala Phe Leu Ile Gly Ala Val Pro Arg Gly Pro

85 90 95Gly Met Glu Arg Gly Asp Leu Leu Lys Gln Asn Gly Gln Ile Phe Ser

100 105 110Leu Gln Gly Ala Ala Leu Asn Thr Ala Ala Lys Arg Asp Ala Lys Ile

115 120 125Phe Val Val Gly Asn Pro Val Asn Thr Asn Cys Trp Ile Ala Met Lys

130 135 140His Ala Pro Arg Leu His Arg Lys Asn Phe His Ala Met Leu Arg Leu145 150 155 160Asp Gln Asn Arg Met His Ser Met Leu Ala His Arg Ala Glu Val Pro

165 170 175Leu Glu Glu Val Ser Arg Val Val Ile Trp Gly Asn His Ser Ala Lys

180 185 190Gln Val Pro Asp Phe Thr Gln Ala Arg Ile Ser Gly Lys Pro Ala Ala

195 200 205Glu Val Ile Gly Asp Arg Asp Trp Leu Glu Asn Ile Leu Val His Ser

210 215 220Val Gln Asn Arg Gly Ser Ala Val Ile Glu Ala Arg Gly Lys Ser Ser225 230 235 240Ala Ala Ser Ala Ser Arg Ala Leu Ala Glu Ala Ala Arg Ser Ile Phe

245 250 255Cys Pro Lys Ser Asp Glu Trp Phe Ser Ser Gly Val Cys Ser Asp His

260 265 270Asn Pro Tyr Gly Ile Pro Glu Asp Leu Ile Phe Gly Phe Pro Cys Arg

275 280 285Met Leu Pro Ser Gly Asp Tyr Glu Ile Ile Pro Gly Leu Pro Trp Glu

290 295 300Pro Phe Ile Arg Asn Lys Ile Gln Ile Ser Leu Asp Glu Ile Ala Gln305 310 315 320Glu Lys Ala Ser Val Ser Ser Leu

325<210>403<211>217<212>PRT<213>肺炎衣原体<400>403Met Lys Arg Val Ile Tyr Lys Thr Ile Phe Cys Gly Leu Thr Leu Leu

5 10 15Thr Ser Leu Ser Ser Cys Ser Leu Asp Pro Lys Gly Tyr Asn Leu Glu

20 25 30Thr Lys Asn Ser Arg Asp Leu Asn Gln Glu Ser Val Ile Leu Lys Glu

35 40 45Asn Arg Glu Thr Pro Ser Leu Val Lys Arg Leu Ser Arg Arg Ser Arg

50 55 60Arg Leu Phe Ala Arg Arg Asp Gln Thr Gln Lys Asp Thr Leu Gln Val65 70 75 80Gln Ala Asn Phe Lys Thr Tyr Ala Glu Lys Ile Ser Glu Gln Asp Glu

85 90 95Arg Asp Leu Ser Phe Val Val Ser Ser Ala Ala Glu Lys Ser Ser Ile

100 105 110Ser Leu Ala Leu Ser Gln Gly Glu Ile Lys Asp Ala Leu Tyr Arg Ile

115 120 125Arg Glu Val His Pro Leu Ala Leu Ile Glu Ala Leu Ala Glu Asn Pro

130 135 140Ala Leu Ile Glu Gly Met Lys Lys Met Gln Gly Arg Asp Trp Ile Trp145 150 155 160Asn Leu Phe Leu Thr Gln Leu Ser Glu Val Phe Ser Gln Ala Trp Ser

165 170 175Gln Gly Val Ile Ser Glu Glu Asp Ile Ala Ala Phe Ala Ser Thr Leu

180 185 190Gly Leu Asp Ser Gly Thr Val Ala Ser Ile Val Gln Gly Glu Arg Trp

195 200 205Pro Glu Leu Val Asp Ile Val Ile Thr

210 215<210>404<211>270<212>PRT<213>肺炎衣原体<400>404Met Ile Ile Ile Lys Asn Asn Glu Leu Met Ile Arg Arg Phe Phe Lys

5 10 15Thr Leu Phe Pro Pro Gly Pro Gln Tyr Ser Leu Cys Tyr Ala Ser Ile

20 25 30Leu Ile Val Leu Ser Ser Leu Val Cys Val Pro Thr Phe Cys Trp Leu

35 40 45Phe Leu Pro Glu Leu Ser Leu Ser Lys Phe Asn Pro Ser Pro Ile Arg

50 55 60Asn Leu Phe Leu Val Ser Ser Thr Leu Ser Lys Val Pro Pro Thr Ala65 70 75 80Ile Ala Glu His Leu Arg Leu Ser Ala Asp Ala Pro Thr Tyr Leu His

85 90 95Glu Phe Ser Ile Lys Glu Ala Glu Ser Ser Leu His Ala Leu Gly Ile

100 105 110Phe Ser Ser Leu Val Ile Glu Lys Ser Pro Asp Asn Lys Gly Ile Thr

115 120 125Ile Phe Tyr Thr Leu Gln Thr Pro Ile Ala Tyr Val Gly Asn Arg Ser

130 135 140Asn Thr Leu Cys Asn Leu Glu Gly Ser Cys Phe Leu Gly Gln Pro Tyr145 150 155 160Phe Pro Ser Leu Asn Leu Pro Gln Ile Phe Phe Ser Gln Glu Asp Leu

165 170 175Lys Met Gln Lys Leu Pro Lys Glu Lys Met Leu Phe Thr Lys Ile Leu

180 185 190Leu Lys Glu Leu Ala Met Glu Ser Pro Lys Ile Ile Asp Leu Ser Leu

195 200 205Ser Asp Ala Tyr Pro Gly Glu Ile Ile Val Thr Leu Ser Ser Gly Ser

210 215 220Leu Leu Arg Leu Pro Ile Lys Thr Leu Asp Arg Ala Leu Asp Leu Tyr225 230 235 240Lys His Met Lys Lys Ser Pro Val Ile Glu Ser Glu Lys Gln Tyr Val

245 250 255Tyr Asp Leu Arg Phe Pro Asn Phe Leu Leu Leu Lys Ala Leu

260 265 270<210>405<211>651<212>PRT<213>肺炎衣原体<400>405Met Val Asn Pro Ile Gly Pro Gly Pro Ile Asp Glu Thr Glu Arg Thr

5 10 15Pro Pro Ala Asp Leu Ser Ala Gln Gly Leu Glu Ala Ser Ala Ala Asn

20 25 30Lys Ser Ala Glu Ala Gln Arg Ile Ala Gly Ala Glu Ala Lys Pro Lys

35 40 45Glu Ser Lys Thr Asp Ser Val Glu Arg Trp Ser Ile Leu Arg Ser Ala

50 55 60Val Asn Ala Leu Met Ser Leu Ala Asp Lys Leu Gly Ile Ala Ser Ser65 70 75 80Asn Ser Ser Ser Ser Thr Ser Arg Ser Ala Asp Val Asp Ser Thr Thr

85 90 95Ala Thr Ala Pro Thr Pro Pro Pro Pro Thr Phe Asp Asp Tyr Lys Thr

100 105 110Gln Ala Gln Thr Ala Tyr Asp Thr Ile Phe Thr Ser Thr Ser Leu Ala

115 120 125Asp Ile Gln Ala Ala Leu Val Ser Leu Gln Asp Ala Val Thr Asn Ile

130 135 140Lys Asp Thr Ala Ala Thr Asp Glu Glu Thr Ala Ile Ala Ala Glu Trp145 150 155 160Glu Thr Lys Asn Ala Asp Ala Val Lys Val Gly Ala Gln Ile Thr Glu

165 170 175Leu Ala Lys Tyr Ala Ser Asp Asn Gln Ala Ile Leu Asp Ser Leu Gly

180 185 190Lys Leu Thr Ser Phe Asp Leu Leu Gln Ala Ala Leu Leu Gln Ser Val

195 200 205Ala Asn Asn Asn Lys Ala Ala Glu Leu Leu Lys Glu Met Gln Asp Asn

210 215 220Pro Val Val Pro Gly Lys Thr Pro Ala Ile Ala Gln Ser Leu Val Asp225 230 235 240Gln Thr Asp Ala Thr Ala Thr Gln Ile Glu Lys Asp Gly Asn Ala Ile

245 250 255Arg Asp Ala Tyr Phe Ala Gly Gln Asn Ala Ser Gly Ala Val Glu Asn

260 265 270Ala Lys Ser Asn Asn Ser Ile Ser Asn Ile Asp Ser Ala Lys Ala Ala

275 280 285Ile Ala Thr Ala Lys Thr Gln Ile Ala Glu Ala Gln Lys Lys Phe Pro

290 295 300Asp Ser Pro Ile Leu Gln Glu Ala Glu Gln Met Val Ile Gln Ala Glu305 310 315 320Lys Asp Leu Lys Asn Ile Lys Pro Ala Asp Gly Ser Asp Val Pro Asn

325 330 335Pro Gly Thr Thr Val Gly Gly Ser Lys Gln Gln Gly Ser Ser Ile Gly

340 345 350Ser Ile Arg Val Ser Met Leu Leu Asp Asp Ala Glu Asn Glu Thr Ala

355 360 365Ser Ile Leu Met Ser Gly Phe Arg Gln Met Ile His Met Phe Asn Thr

370 375 380Glu Asn Pro Asp Ser Gln Ala Ala Gln Gln Glu Leu Ala Ala Gln Ala385 390 395 400Arg Ala Ala Lys Ala Ala Gly Asp Asp Ser Ala Ala Ala Ala Leu Ala

405 410 415Asp Ala Gln Lys Ala Leu Glu Ala Ala Leu Gly Lys Ala Gly Gln Gln

420 425 430Gln Gly Ile Leu Asn Ala Leu Gly Gln Ile Ala Ser Ala Ala Val Val

435 440 445Ser Ala Gly Val Pro Pro Ala Ala Ala Ser Ser Ile Gly Ser Ser Val

450 455 460Lys Gln Leu Tyr Lys Thr Ser Lys Ser Thr Gly Ser Asp Tyr Lys Thr465 470 475 480Gln Ile Ser Ala Gly Tyr Asp Ala Tyr Lys Ser Ile Asn Asp Ala Tyr

485 490 495Gly Arg Ala Arg Asn Asp Ala Thr Arg Asp Val Ile Asn Asn Val Ser

500 505 510Thr Pro Ala Leu Thr Arg Ser Val Pro Arg Ala Arg Thr Glu Ala Arg

515 520 525Gly Pro Glu Lys Thr Asp Gln Ala Leu Ala Arg Val Ile Ser Gly Asn

530 535 540Ser Arg Thr Leu Gly Asp Val Tyr Ser Gln Val Ser Ala Leu Gln Ser545 550 555 560Val Met Gln Ile Ile Gln Ser Asn Pro Gln Ala Asn Asn Glu Glu Ile

565 570 575Arg Gln Lys Leu Thr Ser Ala Val Thr Lys Pro Pro Gln Phe Gly Tyr

580 585 590Pro Tyr Val Gln Leu Ser Asn Asp Ser Thr Gln Lys Phe Ile Ala Lys

595 600 605Leu Glu Ser Leu Phe Ala Glu Gly Ser Arg Thr Ala Ala Glu Ile Lys

610 615 620Ala Leu Ser Phe Glu Thr Asn Ser Leu Phe Ile Gln Gln Val Leu Val625 630 635 640Asn Ile Gly Ser Leu Tyr Ser Gly Tyr Leu Gln

645 650<210>406<211>1074<212>DNA<213>沙眼衣原体血清变型D<400>406gtgcgtaaaa ctgtcattgt tgctatgtct ggaggagtgg attcctcggt tgttgcttat 60ctcttaaaga agcaagggga gtataatgtt gttgggctct tcatgaaaaa ttggggagag 120caggacgaga atggtgagtg tactgcaacc aaagattttc gcgatgtaga gcggatcgca 180gaacaattgt ccattccata ttacacagtt tccttttcta aggaatataa agagcgagtg 240ttttctagat ttctaagaga atatgcgaac ggctacactc ccaatcctga tgtgttatgc 300aatcgagaaa tcaaatttga tttattacag aagaaggtac gtgagctaaa aggtgatttt 360ttagccacgg gacattattg tcgaggaggg gctgatggaa ctggtttgtc cagaggaata 420gaccccaata aagaccaaag ttatttctta tgtggcactc ctaaggatgc tttatccaat 480gtacttttcc ccctgggagg tatgtataaa acggaggtac gtcgaattgc tcaagaagct 540ggtttagcta ccgccacaaa aaaagatagc acagggattt gcttcattgg taaacggcct 600tttaagagtt tccttgagca gtttgtagca gactctcctg gagacattat tgattttgat 660acacaacagg tagtcggccg acatgaagga gcccattatt atacgattgg acagcgtcga 720gggttaaaca taggaggaat ggaaaagcct tgttatgttc ttagcaagaa tatggaaaag 780aatattgttt acattgtaag gggtgaagat catcctttac tttatcgaca agagctttta 840gctaaggaac ttaattggtt tgttcccttg caggagccta tgatctgtag tgctaaagtt 900cggtacagat cccctgacga gaaatgttct gtatatcctt tggaagatgg aacggtaaaa 960gtgattttcg atgtccctgt gaaagctgtc acccctggac agactgtagc tttctaccag 1020ggggacattt gtttaggagg aggagtgatt gaagtgccta tgattcatca gctg 1074<210>407<211>1827<212>DNA<213>沙眼衣原体血清变型D<400>407atgggttttt ggagaacatc gattatgaaa atgaatagga tttggctatt actgcttacc 60ttttcttctg ccatacattc tcctgtacaa ggagaaagct tggtttgcaa gaatgctctt 120caagatttga gttttttaga gcatttatta caggttaaat atgctcctaa aacatggaaa 180gagcaatact taggatggga tcttgttcaa agctccgttt ctgcacagca gaagcttcgt 240acacaagaaa atccatcaac aagtttttgc cagcaggtcc ttgctgattt tatcggagga 300ttaaatgact ttcacgctgg agtaactttc tttgcgatag aaagtgctta ccttccttat 360accgtacaaa aaagtagtga cggccgtttc tactttgtag atatcatgac tttttcttca 420gagatccgtg ttggagatga gttgctagag gtggatgggg cgcctgtcca agatgtactc 480gctactctat atggaagcaa tcacaaaggg actgcagctg aagagtcggc tgctttaaga 540acactatttt ctcgcatggc ctctttaggg cacaaagtac cttctgggcg cactacttta 600aagattcgtc gtccttttgg tactacgaga gaagttcgtg tgaaatggcg ttatgttcct 660gaaggtgtag gagatttggc taccatagct ccttctatca gggctccaca gttacagaaa 720tcgatgagaa gctttttccc taagaaagat gatgcgtttc atcggtctag ttcgctattc 780tactctccaa tggttccgca tttttgggca gagcttcgca atcattatgc aacgagtggt 840ttgaaaagcg ggtacaatat tgggagtacc gatgggtttc tccctgtcat tgggcctgtt 900atatgggagt cggagggtct tttccgcgct tatatttctt cggtgactga tggggatggt 960aagagccata aagtaggatt tctaagaatt cctacatata gttggcagga catggaagat 1020tttgatcctt caggaccgcc tccttgggaa gaatttgcta agattattca agtattttct 1080tctaatacag aagctttgat tatcgaccaa acgaacaacc caggtggtag tgtcctttat 1140ctttatgcac tgctttccat gttgacagac cgtcctttag aacttcctaa acatagaatg 1200attctgactc aggatgaagt ggttgatgct ttagattggt taaccctgtt ggaaaacgta 1260gacacaaacg tggagtctcg ccttgctctg ggagacaaca tggaaggata tactgtggat 1320ctacaggttg ccgagtattt aaaaagcttt ggacgtcaag tattgaattg ttggagtaaa 1380ggggatatcg agttatcaac gcctattcct ctttttggtt ttgagaagat tcatccacat 1440cctcgagttc aatactctaa accgatttgt gttttgatca atgagcaaga cttttcttgt 1500gctgacttct tccctgtagt tttgaaagac aatgatcgag ctcttattgt tggtactcga 1560acagctggag ctggaggatt tgtctttaat gtgcagttcc caaatagaac tggaataaaa 1620acttgttctt taacaggatc attagctgtt agagagcatg gtgccttcat tgagaacatc 1680ggagtcgaac cgcatatcga tctgcctttt acagcgaatg atattcgcta taaaggctat 1740tccgagtatc ttgataaggt caaaaaattg gtttgtcagc tgatcaataa cgacggtacc 1800attattcttg cggaagatgg tagtttt 1827<210>408<211>804<212>DNA<213>沙眼衣原体血清变型D<400>408ttgccccccc gctccccctc ttttttagta catatatggc gtcttttttt tgctaaaggg 60ccgaattatt ctcttcccta cgctttcctg tgtatcttcg ttagcgttct cgtcttttta 120cccatcggct tatggctgac tctgcctagt tttttaaatt tcaagcactc cctaacgcct 180attaagacat tgtttcttac ctgtacggag cctccttgcc ttcctgagcc ttttttctcg 240gatatcttgc atctttctgc tgattcccct ccagctttac agacattttc cacgaagtct 300gccgagcact ttttaaatga attaggagtt ttttctttta tttctattga gaaggttcct 360gatcataaag gcttagctat ttcctatgct ttgcatactc cgttagcttt tttaggaaat 420caaactcata cattcatagg ttatgaagga caaaccttcc cagctttgcc cttttttcaa 480tccttagaac tacctacagt cttcttttcg caacaagctc tttcccaaac acgcattcca 540catcaaacac tgtctattgt cacgagccta atagatcaac tacagatgga tcctcctagc 600atcattgact tatctcaaat cgatcattat ccgggagaat ttgtggtatc cttatcttct 660ggaacactct tacgttttcg taaagactct ttccttcctg gaatccaaca ctatcaacaa 720gcactctctc taggagcctt ctctcctcaa caagctgtca tttgcgacct tcgttgcgaa 780gactatcttt tacttaaacg taaa 804<210>409<211>663<212>DNA<213>沙眼衣原体血清变型D<400>409atgaaaaagt ttatctataa gtatagcttt ggagctctct tgttgctctc cgggctctcc 60ggattgagca gctgttgcgc caactcttat ggatcgactc ttgcaaaaaa tacagccgag 120ataaaagaag aatctgttac acttcgcgag aagccggatg ccggctgtaa aaagaaatct 180tcttgttact tgagaaaatt tttctcgcgc aagaaaccta aagagaagac agagcctgtg 240ttgccgaact ttaagtctta cgcagatcca atgacagatt ccgaaagaaa agacctttct 300ttcgtagtat ctgctgctgc tgataagtct tctattgctt tggctatggc tcagggggaa 360attaaaggcg cattatcgcg tattagagag atccatcctc ttgcattgtt acaagctctt 420gcagaagatc ctgctttaat tgctggaatg aaaaagatgc aaggacggga ttgggtctgg 480aatatcttta tcacagaatt aagcaaagtt ttttctcaag cagcatcttt aggggctttc 540agcgttgcag acgttgccgc gttcgcgtcg accttaggat tagactcggg gaccgttacc 600tcaattgttg atggggaaag gtgggctgag ctgatcgatg tcgtgattca gaaccctgct 660ata 663<210>410<211>1470<212>DNA<213>沙眼衣原体血清变型D<400>410atgagcgacc tctcggacct atttaaaact catttcacac agtatgcgtc ttacgtcatt 60ttggaacgtg caatccctca tgttttagat ggcctcaagc ctgttcaaag aaggcttctt 120tggaccttat tccgtatgga tgatggtaaa atgcataagg tggctaatat cgcaggacgt 180acgatggcgc tgcacccgca tggtgatgcg cctatcgtgg aagctcttgt cgttttggca 240aataaagggt tcctgataga gacacaaggg aactttggta accctctcac aggagatcct 300catgcagcgg ctcgttatat agaagcgcgg ctaagccctt tagctaaaga ggtacttttt 360aatacggatc tcatgacctt ccatgattct tacgatggaa gagagcaaga acccgatatc 420ttagctgcaa agattcctct actactcctt catggcgtgg atggcatcgc agtagggatg 480actacaaaaa ttttccctca caacttttgt gatctactag aagcacaaat agctatactg 540aatgaccaac cgttttctct ccttcccgac ttccctccag gaggcacgat ggatgcttcc 600gactaccaag atggcttagg atccattgtt ctgcgcgcaa caattgatat tattaatgac 660aaaaccttgc taatcaaaga aatctgtcct tccacaacta cagagactct aattcgttct 720atcgaaaacg cagcaaaacg aggaatcatt aaaatcgatt cgattcaaga tttctctacg 780gacctccctc atatcgagat caaactccct aaaggtatct acgctaaaga tctgttacgc 840cctctatata cacatacaga atgtcaggtt atcttaacct ctcggccaac agctatttac 900cagggaaaac cttgggaaac aacgatcagc gaaatcctac gcttacaaac caagactctc 960caaaattacc taaaaaaaga attactcata ctagaagatt ccttaagccg cgagctgtac 1020cacaaaactt tagaatatct attcattaaa cataagcttt acgataccgt gcgctccatg 1080ctttctaaaa gaaagacgtc tccttcatca agtaccattc acaacgctgt tttggaagct 1140ctgactccat ttcttgacac gctcccggct cctgataagc aagcaaccgc tcaactagca 1200gctctaacta ttaaaaaaat cctctgtttt gatgaaaatt cctacgagaa ggagctggca 1260tgcttagaaa agaaacgcag tagcgtacag aaagatctga gccaactgaa aaaatacaca 1320gttctctaca ttaagaagct gctcgaaacc tacagacaac tcgggcatcg aaagacaaaa 1380attgcaaaat ttgatgacct acctaccgag agagtctccg ctcataagaa agcaaaagaa 1440ctcgctgcgc tcgatcaaga agagaacttc 1470<210>411<211>234<212>DNA<213>沙眼衣原体血清变型D<400>411atgaaagagt ttttagcgta cattgtaaaa aatcttgttg ataagccaga ggaagtgcat 60ctgaaagagg tgcagggaac caatacgatt atctacgaat tgactgttgc taagggagat 120atcggtaaaa ttatcggtaa agaaggacgc actattaagg ctatccgtac tttattggtt 180tccgtagcaa gtcgagataa tgtgaaagtc agcctagaaa ttatggaaga gcgg 234<210>412<211>1941<212>DNA<213>沙眼衣原体血清变型D<400>412atggaatcag gaccagaatc agtttcttct aatcagagct cgatgaatcc aattattaat 60gggcaaatcg cttctaattc ggagaccaaa gagtccacga aggagtcaga agcgagtcct 120tcagcatcgt cctctgtaag cagctggagt tttttatcct cagcaaagca tgcattaatc 180tctcttcgtg atgccatctt gaataaaaat tctagtccaa cagactctct ctctcaatta 240gaggcctcta cttctacctc tacggttaca cgtgtagctg cgcgagatta taatgaggct 300aaatcgaatt ttgatacggc gaaaagtgga ttagagaacg ctacgacact tgctgaatac 360gagacgaaaa tggctgattt aatggcagct ctccaagata tggagcgttt ggctaaacag 420aaggctgaag ttacaagaat taaagaagct cttcaagaga aacaagaggt tattgataag 480ctcaatcagt tagttaaact tgaaaaacag aatcagactt taaaggaaac tttaacaacc 540acagactctg cagatcagat tccagcgatt aatagtcagt tagagatcaa caaaaattct 600gcagatcaaa ttatcaaaga tctggaagga caaaacataa gttatgaagc tgttctcact 660aacgcaggag aggttatcaa agcttcttct gaagcgggaa ttaagttagg acaagctttg 720cagtctattg tggatgctgg ggatcaaagc caggctgcag ttcttcaagc acagcaaaat 780aatagcccag ataatatcgc agccacgaag aaattaattg atgctgctga aacgaaggta 840aacgagttaa aacaagagca tacagggcta acggactcgc ctttagtgaa aaaagctgag 900gagcagatta gtcaagcaca aaaagatatt caagagatca aacctagtgg ttcggatatt 960cctatcgttg gtccgagtgg gtcagctgct tccgcaggaa gtgcggtagg agcgttgaaa 1020tcctctaaca attcaggaag aatttccttg ttgcttgatg atgtagacaa tgaaatggca 1080gcgattgcaa tgcaaggttt tcgatctatg atcgaacaat ttaatgtaaa caatcctgca 1140acagctaaag agctacaagc tatggaggct cagctgactg cgatgtcaga tcaactggtt 1200ggtgcggatg gcgagctccc agccgaaata caagcaatca aagatgctct tgcgcaagct 1260ttgaaacaac catcaacaga tggtttagct acagctatgg gacaagtggc ttttgcagct 1320gccaaggttg gaggaggctc cgcaggaaca gctggcactg tccagatgaa tgtaaaacag 1380ctttacaaga cagcgttttc ttcgacttct tccagctctt atgcagcagc actttccgat 1440ggatattctg cttacaaaac actgaactct ttatattccg aaagcagaag cggcgtgcag 1500tcagctatta gtcaaactgc aaatcccgcg ctttccagaa gcgtttctcg ttctggcata 1560gaaagtcaag gacgcagtgc agatgctagc caaagagcag cagaaactat tgtcagagat 1620agccaaacgt taggtgatgt atatagccgc ttacaggttc tggattcttt gatgtctacg 1680attgtgagca atccgcaagt aaatcaagaa gagattatgc agaagctcac ggcatctatt 1740agcaaagctc cacaatttgg gtatcctgct gttcagaatt ctgcggatag cttgcagaag 1800tttgctgcgc aattggaaag agagtttgtt gatggggaac gtagtctcgc agaatctcga 1860gagaatgcgt ttagaaaaca gcccgctttc attcaacagg tgttggtaaa cattgcttct 1920ctattctctg gttatctttct 1941<210>413<211>693<212>DNA<213>沙眼衣原体血清变型D<400>413atgatggagg tgtttatgaa ttttttagat cagttagatt taattattca aaataagcat 60atgctagaac acacatttta tgtgaaatgg tcgaaggggg agcttactaa agagcaatta 120caggcgtatg ccaaagacta ttatttacat atcaaagcct ttcctaaata tttatctgcg 180attcatagtc gttgcgatga tttagaggcg cgtaagttat tgttagataa cttgatggat 240gaagagaacg gttaccctaa tcatattgat ttgtggaagc agtttgtgtt tgctctagga 300gttactccag aagagttaga ggctcatgag cctagtgaag cagcaaaagc gaaagtagct 360actttcatgc ggtggtgtac aggagattct ttagctgcag gagtggctgc tttgtattct 420tatgagagtc aaattccacg tatcgctaga gagaaaattc gtggattgac tgagtacttt 480ggattttcca atcctgaaga ctatgcatat ttcacagaac atgaagaagc ggatgtgcgg 540catgctagag aagaaaaagc gctcattgag atgcttctca aagatgacgc tgataaagtg 600ttagaggcat cgcaagaagt aacgcaatct ttgtatggct ttttagattc ttttttggat 660ccaggaactt gttgtagttg tcatcaatct tat 693<210>414<211>1599<212>DNA<213>沙眼衣原体血清变型D<400>414ttgtctaata gttttcgaga ccaagaacaa ggtttacagg cagtctttcg cgccgcgcgt 60gtaatatctc atatgttttc tcagacaatc ggtccttatg ggtttagcac gattgttcat 120aatgtccagg atacgcggac aacgcaagat agtcagagta tgctgaagga tattctgttt 180ccagatgtct ttgaaaatat aggtatgaaa ctcatccgag atactgcctt gcgaactcgt 240atgcgattcg gagatggggc aaaaaccaca gctttactaa tagaagcgtt attagcggag 300ggcatgacag gtatccagaa aggtttggat cctcatgaaa tccatcgagg aatgcttctt 360gcggaaaaga aaatccaaga ggttttttat agagaaacat ttcctctaag cgatctggaa 420catacagtgt atgtatccag tatcgcgcga cgttgtaata gcgaaatcgc gtctgtttta 480tctagcgcag tgggttatgg agggaagaac ggttactata tcgtagaaga acatgaagag 540catgaaacat actggcatgc cgaagagcat gctgtgtggg attttggata tgcttctcct 600tactttatta cgcatgcgga aacaggaacg gtagaatata gccaggttta tattttagtt 660agtgaacagc cgctgcatta ttcgaaccca tcttttttaa catttcttca atcagttgtt 720caggcaggga aaacaccgct tgtgatttta gcagaagctt ttgataaaga attattagct 780atgctggaaa tgaatcaaat agagagggtt ttccctgtct gtgctgtgaa agtatctggg 840aagcacgccc gggaatcttt agaggacatt gcggtattaa ccggagctac attgctctca 900gaaatggatt tcgaagacag cgaggaagag agaatcacaa atcgattagg ctttgtagca 960ggaatttgtg tttcttctac cagtctttgt gtccctagag aaacagacaa taagcagaga 1020atggcagaac actgtgcttt tttacaggat aaattgagtt tctcacagga agaagaggct 1080agcgctaggt tgagaaggag attggcaagg ctttcttcag gcgaagtatg tattcatatt 1140gctgcagact gtattcctca ggaggagata ggttatatca cctcttctat acgagccatg 1200acagaatctt tacgatcagg atgcttgcct ggaggtgggt gcgcattcat tcgagcggca 1260agagaaattt ctgttccgct tgctctttct cctagtgagc gttttggttt tcttgctgtg 1320cttagtgccg cagagaagcc ttttcgtgcc attgttactc gcagcagaag agtggaggag 1380gaggtgttct ctgaagtctt ctctcaagcg gactggcgag taggatttaa cggagtttct 1440ggatttgtgg aagatattgt ttcgcaaggg atttgtgatg gagcctcttg tattcagtat 1500gctttaagtc atgcagtggg gacgactggt ctgttgttaa catctgcgct ctttatagct 1560tcgcaggagc cgatgttgag agaggaaaat tctgaagaa 1599<210>415<211>1395<212>DNA<213>沙眼衣原体血清变型D<400>415atgaatgaag ctttcgactg tgtagttatc ggagcggggc cagggggcta tgttgcagca 60atcactgccg ctcaagcagg actcaaaact gcgctaatcg aaaagcgaga ggctggcgga 120acctgtttaa accgagggtg tattccttct aaagccctct tagcaggagc tgaagtcgtt 180acccaaatac gccatgctga ccagtttggg attcatgtag aaggattcag catcaactat 240cccgctatgg tacaaaggaa ggattccgta gtccgtagca tccgcgatgg acttaatggt 300ctcattcgca gcaataagat cactgtcttc tctggaagag gctctttgat ctcttcaaca 360gaagtaaaaa tcttaggaga aaacccttct gtaatcaaag cgcactccat tatcctagcc 420accggctctg aaccacgagc tttccccggg attccttttt ccgcagaatc tcctcggatt 480ttatgctcaa caggcgtgct aaacctcaaa gaaatccctc aaaaaatggc cattattggc 540ggtggtgtga tcggttgcga attcgcttcc ttattccata cgttaggctc cgaagtttct 600gtgatcgaag caagctctca aatccttgct ttgaataatc cagatatttc aaaaaccatg 660ttcgataaat tcacccgaca aggactccgt ttcgtactag aagcctctgt atcaaatatt 720gaggatatag gagatcgcgt tcggttaact atcaatggga atgtcgaaga atacgattac 780gttctcgtat ctataggacg ccgtttgaat acagaaaata ttggcttgga taaagctggt 840gttatttgtg atgaacgcgg agtcatccct accgatgcca caatgcgcac aaacgtacct 900aacatttatg ctattggaga tatcacagga aaatggcaac ttgcccatgt agcttctcat 960caaggaatca ttgcagcacg gaatatagct ggccataaag aggaaatcga ttactctgcc 1020gtcccttctg tgatctttac cttccctgaa gtcgcttcag taggcctatc cccaacagca 1080gctcaacaac aaaaaatccc cgtcaaagta acaaaattcc catttcgagc tattggaaaa 1140gcggtcgcaa tgggcgaggc cgatggattt gcagccatta tcagccatga gactactcag 1200cagatcctag gagcttatgt gattggccct catgcctcat cactgatttc cgaaattacc 1260ctagcagttc gtaatgaact gactcttcct tgtatttacg aaactatcca cgcacatcca 1320accttagcag aagtttgggc tgaaagtgcg ttgttagctg ttgatacccc attacatatg 1380ccccctgcta aaaaa 1395<210>416<211>366<212>DNA<213>沙眼衣原体血清变型D<400>416atgccacgca tcattggaat agatattcct gcgaaaaaga aattaaaaat aagtcttaca 60tatatttatg gaatagggcc agctctttct aaagagatca ttgctagatt gcagttgaat 120cccgaagcta gagctgcaga gttgactgag gaagaggttg gtcgactaaa cgctctttta 180cagtcggatt acgttgttga aggggatttg cgccgtcgtg tgcaatctga tatcaaacgt 240ctgattacta tccatgctta tcgtggacaa agacatagac tttctttgcc tgttcgtggt 300cagagaacaa aaacaaattc tcgcacgcgt aagggtaaac gtaaaactgt tgcaggtaag 360aagaaa 366<210>417<211>1659<212>DNA<213>沙眼衣原体血清变型D<400>417atgcgaatag gagatcctat gaacaaactc atcagacgag cagtgacgat cttcgcggtg 60actagtgtgg cgagtttatt tgctagcggg gtgttagaga cctctatggc agagtctctc 120tctacaaacg ttattagctt agctgacacc aaagcgaaag acaacacttc tcataaaagc 180aaaaaagcaa gaaaaaacca cagcaaagag actcccgtag accgtaaaga ggttgctccg 240gttcatgagt ctaaagctac aggacctaaa caggattctt gctttggcag aatgtataca 300gtcaaagtta atgatgatcg caatgttgaa atcacacaag ctgttcctga atatgctacg 360gtaggatctc cctatcctat tgaaattact gctacaggta aaagggattg tgttgatgtt 420atcattactc agcaattacc atgtgaagca gagttcgtac gcagtgatcc agcgacaact 480cctactgctg atggtaagct agtttggaaa attgaccgct taggacaagg cgaaaagagt 540aaaattactg tatgggtaaa acctcttaaa gaaggttgct gctttacagc tgcaacagta 600tgcgcttgtc cagagatccg ttcggttaca aaatgtggac aacctgctat ctgtgttaaa 660caagaaggcc cagagaatgc ttgtttgcgt tgcccagtag tttacaaaat taatatagtg 720aaccaaggaa cagcaacagc tcgtaacgtt gttgttgaaa atcctgttcc agatggttac 780gctcattctt ctggacagcg tgtactgacg tttactcttg gagatatgca acctggagag 840cacagaacaa ttactgtaga gttttgtccg cttaaacgtg gtcgtgctac caatatagca 900acggtttctt actgtggagg acataaaaat acagcaagcg taacaactgt gatcaacgag 960ccttgcgtac aagtaagtat tgcaggagca gattggtctt atgtttgtaa gcctgtagaa 1020tatgtgatct ccgtttccaa tcctggagat cttgtgttgc gagatgtcgt cgttgaagac 1080actctttctc ccggagtcac agttcttgaa gctgcaggag ctcaaatttc ttgtaataaa 1140gtagtttgga ctgtgaaaga actgaatcct ggagagtctc tacagtataa agttctagta 1200agagcacaaa ctcctggaca attcacaaat aatgttgttg tgaagagctg ctctgactgt 1260ggtacttgta cttcttgcgc agaagcgaca acttactgga aaggagttgc tgctactcat 1320atgtgcgtag tagatacttg tgaccctgtt tgtgtaggag aaaatactgt ttaccgtatt 1380tgtgtcacca acagaggttc tgcagaagat acaaatgttt ctttaatgct taaattctct 1440aaagaactgc aacctgtatc cttctctgga ccaactaaag gaacgattac aggcaataca 1500gtagtattcg attcgttacc tagattaggt tctaaagaaa ctgtagagtt ttctgtaaca 1560ttgaaagcag tatcagctgg agatgctcgt ggggaagcga ttctttcttc cgatacattg 1620actgttccag tttctgatac agagaataca cacatctat 1659<210>418<211>576<212>DNA<213>沙眼衣原体血清变型D<400>418atgcctgaag gggaaatgat gcataagttg caagatgtca tagatagaaa gttgttggat 60tctcgtcgta ttttcttctc cgaacctgta acggagaaaa gtgctacaga agccatcaaa 120aagctttggt atttggaact caccaatcct gggcagccaa ttgtatttgt cattaatagc 180cctggagggt ctgttgatgc tgggtttgct gtttgggacc aaattaaaat gatctcttct 240cctttgacta cagttgttac aggtttagca gcatctatgg gatctgtatt gagtttgtgt 300gctgttccag gaagacgttt tgctacgcct catgcgcgca ttatgattca ccagccttct 360attggaggaa ccattactgg tcaagccacg gacttggata ttcatgctcg tgaaatttta 420aaaacaaaag cacgcattat tgatgtgtat gtcgaggcaa ctggacaatc tcgagaggtg 480atagagaaag ctatcgatcg agatatgtgg atgagtgcaa atgaagcaat ggagtttgga 540ctgttagatg ggattctctt ctcttttaac gacttg 576<210>419<211>825<212>DNA<213>沙眼衣原体血清变型D<400>419atgggattct cttctctttt aacgacttgt agatatcttt tatattctgg agcaggaaac 60agtttcattt tgggagaatc gatgccttct cttgaggatg ttctgttttt atgccaggaa 120gagatggttg atgggttttt atgtgtagag tcttctgaaa tagcagatgc taaactcact 180gtttttaata gtgatggatc tatcgcgtct atgtgcggga atgggttgcg gtgcgcaatg 240gcgcacgtag cccagtgctt tggacttgaa gatgtttcta ttgaaacaga acgtggtgtt 300taccaaggta agttcttttc tatgaatcgg gtattggttg atatgacatt acctgattgg 360aaaaaagctg agcggaaatt aacgcatgtg ttgcctggta tgccggaaca agtatttttt 420attgatacag gggttccgca tgtcgtggtt ttcgtttctg atttaagtaa ggttcccgta 480caagaatggg ggtctttctt gcgttatcat gaagattttg ctcctgaagg tgtaaatgta 540gattttgttc agcggaagaa ggatgatcta ctgcttgtct atacttatga gcgaggttgt 600gagcgagaaa ccttatcttg tgggacaggg atgttggcaa gtgctttggt tgcagcggat 660atcttttctc taggacaaga tttctctata gcggtgtgtt ctcgtagtag aaatctgatt 720aagatttttt ctgagaaagg caaggtattt ttagagggtc ctgtgagcct attgaatcgt 780agtgagaact ttgggtggtt agagcctaaa tcaagacgtt ttgga 825<210>420<211>5310<212>DNA<213>沙眼衣原体血清变型D<400>420atgaaattta tgtcagctac tgctgtattt gctgcagcac tctcctccgt tactgaggcg 60agctcgatcc aagatcaaat aaagaatacc gactgcaatg ttagcaaatt aggatattca 120acttctcaag catttactga tatgatgcta gcagacaaca cagagtatcg agctgctgat 180agtgtttcat tctatgactt ttcgacatct tccagattac ctagaaaaca tcttagtagt 240agtagtgaag cttctccaac gacagaagga gtgtcttcat cttcatctgg agaaactgat 300gagaaaacag aagaagaact agacaatggc ggaatcattt atgctagaga gaaactaact 360atctcagaat ctcaggactc tctctctaat caaagcatag aactccatga caatagtatt 420ttcttcggag aaggtgaagt tatctttgat cacagagttg ccctcaaaaa cggaggagct 480atttatggag agaaagaggt agtctttgaa aacataaaat ctctactagt agaagtaaat 540atcgcggtcg agaaaggggg tagcgtctat gcaaaagaac gagtatcttt agaaaatgtt 600accgaagcaa ccttctcctc caatggtggg gaacaaggtg gtggtggaat ctattcagaa 660caggatatgt taatcagtga ttgcaacaat gtacatttcc aagggaatgc tgcaggagca 720acagcagtaa aacaatgtct ggatgaagaa atgatcgtat tgctcgcaga atgcgttgat 780agcttatccg aagatacact ggatagcact ccagaaacgg aacagactga gtcaaatgga 840aatcaagacg gttcgtctga aacagaagat acacaagtat cagaatcacc agaatcaact 900cctagccccg acgatgtttt aggtaaaggt ggtggtatct atacagaaaa atctttgacc 960atcactggaa ttacagggac tatagatttt gtcagtaaca tagctaccga ttctggagca 1020ggtgtattca ctaaagaaaa cttgtcttgc accaacacga atagcctaca gtttttgaaa 1080aactcggcag gtcaacatgg aggaggagcc tacgttactc aaaccatgtc tgttactaat 1140acaactagtg aaagtataac tactccccct ctcataggag aagtgatttt ctctgaaaat 1200acagctaaag ggcacggtgg tggtatctgc actaacaaac tttctttatc taatttaaaa 1260acggtgactc tcactaaaaa ctctgcaaag gagtctggag gagctatttt tacagatctg 1320gcgtctatac caataacaga taccccagaa tcttctaccc cctcttcctc ctcgcctgca 1380agcactcctg aagtagttgc ttctgctaaa ataaatcgat tctttgcctc tacggcaaaa 1440ccggcagccc cttctctaac agaggctgag tctgatcaaa cggatcaaac agaaacttct 1500gatactaata gcgatataga cgtgtcgatt gagaacattt tgaatgtcgc tatcaatcaa 1560aacacttctg cgaaaaaagg aggggctatt tacgggaaaa aagctaaact ttcccgtatt 1620aacaatcttg aactttcagg gaattcatcc caggatgtag gaggaggtct ctgtttaact 1680gaaagcgtag aatttgatgc aattggatcg ctcttatccc actataactc tgctgctaaa 1740gaaggtgggg ctattcattc taaaacggtt actctatcta acctcaagtc taccttcact 1800tttgcagata acactgttaa agcaatagta gaaagcactc ctgaagctcc agaagagatt 1860cctccagtag aaggagaaga gtctacagca acagaagatc caaattctaa tacagaagga 1920agttcggcta acactaacct tgaaggatct caaggggata ctgctgatac agggactggt 1980gatgttaaca atgagtctca agacacatca gatactggaa acgctgaatc tgaagaacaa 2040ctacaagatt ctacacaatc taatgaagaa aatacccttc ccaatagtaa tattgatcaa 2100tctaacgaaa acacagacga atcatctgat agccacactg aggaaataac tgacgagagt 2160gtctcatcgt cctctgaaag tggatcatct actcctcaag atggaggagc agcttcttca 2220ggggctccct caggagatca atctatctct gcaaacgctt gtttagctaa aagctatgct 2280gcgagtactg atagctcccc cgtatctaat tcttcaggtt cagaagagcc tgtcacttct 2340tcttcagatt cagacgttac tgcatcttct gataatccag actcttcctc atctggagat 2400agcgctggag actctgaaga accgactgag ccagaagctg gttctacaac agaaactctt 2460actttaatag gaggaggtgc tatctatgga gaaactgtta agattgagaa cttctctggc 2520caaggaatat tttctggaaa caaagctatc gataacacca cagaaggctc ctcttccaaa 2580tctgacgtcc tcggaggtgc ggtctatgct aaaacattgt ttaatctcga tagcgggagc 2640tctagacgaa ctgtcacctt ctccgggaat actgtctctt ctcaatctac aacaggtcag 2700gttgctggag gagctatcta ctctcctact gtaaccattg ctactcctgt agtattttct 2760aaaaactctg caacaaacaa tgctaataac actacagata ctcagagaaa agacaccttt 2820ggaggagcta tcggagctac ttctgctgtt tctctatcag gaggggctca tttcttagaa 2880aacgttgctg acctcggatc tgctattggg ttggtgccag gcacacaaaa tacagaaaca 2940gtgaaattag agtctggctc ctactacttt gaaaaaaata aagctttaaa acgagctact 3000atttacgcac ctgtcgtttc cattaaagcc tatactgcga catttaacca aaacagatct 3060ctagaagaag gaagcgcgat ttactttaca aaagaagcat ctattgagtc tttaggctct 3120gttctcttca caggaaactt agtaacccta acgctaagca caactacaga aggcacacca 3180gccacaacct caggagatgt aacaaaatat ggtgctgcta tctttggaca aatagcaagc 3240tcaaacggat ctcagacgga taaccttccc ctgaaactca ttgcttcagg aggaaatatt 3300tgtttccgaa acaatgaata ccgtcctact tcttctgata ccggaacctc tactttctgt 3360agtattgcgg gagatgttaa attaaccatg caagctgcaa aagggaaaac gatcagtttc 3420tttgatgcaa tccggacctc tactaagaaa acaggtacac aggcaactgc ctacgatact 3480ctcgatatta ataaatctga ggattcagaa actgtaaact ctgcgtttac aggaacgatt 3540ctgttctcct ctgaattaca tgaaaataaa tcctatattc cacaaaacgt agttctacac 3600agtggatctc ttgtattgaa gccaaatacc gagcttcatg ttatttcttt tgagcagaaa 3660gaaggctctt ctctcgttat gacacctgga tctgttcttt cgaaccagac tgttgctgat 3720ggagctttgg tcataaataa catgaccatt gatttatcca gcgtagagaa aaatggtatt 3780gctgaaggaa atatctttac tcctccagaa ttgagaatca tagacactac tacaggtgga 3840agcggtggaa ccccatctac agatagtgaa agtaaccaga atagtgatga taccgaggag 3900caaaataata atgacgcctc gaatcaagga gaaagcgcga atggatcgtc ttctcctgca 3960gtagctgctg cacacacatc tcgtacaaga aactttgccg ctgcagctac agccacacct 4020acgacaacac caacggctac aactacaaca agcaaccaag taatcctagg aggagaaatt 4080aaactcatcg atcctaatgg gaccttcttc cagaaccctg cattaagatc cgac aacaa 4140atctccttgt tagtgctccc tacagactca tcaaaaatgc aagctcagaa aatagtactg 4200acgggtgata ttgctcctca gaaaggatat acaggaacac tcactctgga tcctgatcaa 4260ctacaaaatg gaacgatctc agtgctctgg aaatttgact cttatagaca atgggcttat 4320gtacctagag acaatcattt ctatgcgaac tcgattctgg gatctcaaat gttaatggtc 4380acagtcaaac aaggcttgct caacgataaa atgaatctag ctcgctttga ggaagttagc 4440tataacaacc tgtggatatc aggactagga acgatgctat cgcaagtagg aacacctact 4500tctgaagaat tcacttatta cagcagagga gcttctgttg ccttagatgc taaaccagcc 4560catgatgtga ttgttggagc tgcatttagt aagatgatcg ggaaaacaaa atccttgaaa 4620agagagaata actacactca caaaggatcc gaatattctt accaagcatc ggtatacgga 4680ggcaaaccat tccactttgt aatcaataaa aaaacggaaa aatcgctacc gctattgtta 4740caaggagtca tctcttacgg atatatcaaa catgatacag tgactcacta tccaacgatc 4800cgtgaacgaa acaaaggaga atgggaagac ttaggatggc tgacagctct ccgtgtctcc 4860tctgtcttaa gaactcctgc acaaggggat actaaacgta tcactgttta cggagaattg 4920gaatactcca gtatccgtca gaaacaattc acagaaacag aatacgatcc tcgttacttc 4980gacaactgca cctatagaaa cttagcaatt cctatggggt tagcattcga aggagagctc 5040tctggtaacg atattttgat gtacaacaga ttctctgtag catacatgct atcaatctat 5100cgaaattctc caacatgcaa ataccaagtg ctctcttcag gagaaggcgg agaaattatt 5160tgtggagtac cgacaagaaa ctcagctcgc ggagaataca gcacgcagct gtacctggga 5220cctttgtgga ctctgtatgg atcctacacg atagaagcag acgcacatac actagctcat 5280atgatgaact gcggtgctcg tatgacattc 5310<210>421<211>5253<212>DNA<213>沙眼衣原体血清变型D<400>421atgaaatggc tgtcagctac tgcggtgttt gctgctgttc tcccctcagt ttcagggttt 60tgcttcccag aacctaaaga attaaatttc tctcgcgtag gaacttcttc ctctaccact 120tttactgaaa cagttggaga agctggggca gaatatatcg tctctggtaa cgcatctttc 180acaaaattta ccaacattcc tactaccgat acaacaactc ccacgaactc aaactcctct 240agctctaacg gagagactgc ttccgtttct gaggatagtg actctacaac aacgactcct 300gatcctaaag gtggcggcgc cttttataac gcgcactccg gagttttatc ctttatgaca 360cgatcaggaa cagaaggttc cttaactctg tctgagataa aaataactgg tgaaggcggt 420gctatcttct ctcaaggaga gctgctattt acagatctga caggtctaac catccaaaat 480aacttatccc agctatccgg aggagcgatt tttggagaat ctacaatctc cctatcaggg 540attactaaag cgactttctc ctccaactct gcagaagttc ctgctcctgt taagaaacct 600acagaaccta aagctcaaac agcaagcgaa acgtcgggtt ctagtagttc tagcggaaat 660gattcggtgt cttcccccag ttccagtaga gctgaacccg cagcagctaa tcttcaaagt 720cactttattt gtgctacagc tactcctgct gctcaaaccg atacagaaac atcaactccc 780tctcataagc caggatctgg gggagctatc tatgctaaag gcgaccttac tatcgcagac 840tctcaagagg tactattctc aataaataaa gctactaaag atggaggagc gatctttgct 900gagaaagatg tttctttcga gaatattaca tcattaaaag tacaaactaa cggtgctgaa 960gaaaagggag gagctatcta tgctaaaggt gacctctcaa ttcaatcttc taaacagagt 1020ctttttaatt ctaactacag taaacaaggt ggtggggctc tatatgttga aggagatata 1080aacttccaag atcttgaaga aattcgcatt aagtacaata aagctggaac gttcgaaaca 1140aaaaaaatca ctttaccaaa agctcaagca tctgcaggaa atgcagatgc ttgggcctct 1200tcctctcctc aatctggttc tggagcaact acagtctcca actcaggaga ctctagctct 1260ggctcagact cggatacctc agaaacagtt ccagccacag ctaaaggcgg tgggctttat 1320actgataaga atctttcgat tactaacatc acaggaatta tcgaaattgc aaataacaaa 1380gcgacagatg ttggaggtgg tgcttacgta aaaggaaccc ttacttgtga aaactctcac 1440cgtctacaat ttttgaaaaa ctcttccgat aaacaaggtg gaggaatcta cggagaagac 1500aacatcaccc tatctaattt gacagggaag actctattcc aagagaatac tgccaaagaa 1560gagggcggtg gactcttcat aaaaggtaca gataaagctc ttacaatgac aggactggat 1620agtttctgtt taattaataa cacatcagaa aaacatggtg gtggagcctt tgttaccaaa 1680gaaatctctc agacttacac ctctgatgtg gaaacaattc caggaatcac gcctgtacat 1740ggtgaaacag tcattactgg caataaatct acaggaggta atggtggagg cgtgtgtaca 1800aaacgtcttg ccttatctaa ccttcaaagc atttctatat ccgggaattc tgcagctgaa 1860aatggtggtg gagcccacac atgcccagat agcttcccaa cggcggatac tgcagaacag 1920cccgcagcag cttctgccgc gacgtctact cccgagtctg ccccagtggt ctcaactgct 1980ctaagcacac cttcatcttc taccgtctct tcattaacct tactagcagc ctcttcacaa 2040gcctctcctg caacctctaa taaggaaact caagatccta atgctgatac agacttattg 2100atcgattatg tagttgatac gactatcagc aaaaacactg ctaagaaagg cggtggaatc 2160tatgctaaaa aagccaagat gtcccgcata gaccaactga atatctctga gaactccgct 2220acagagatag gtggaggtat ctgctgtaaa gaatctttag aactagatgc cctagtctcc 2280ttatctgtaa cagagaacct tgttgggaaa gaaggtggag gcttacatgc taaaactgta 2340aatatttcta atctgaaatc aggcttctct ttctcgaaca acaaagcaaa ctcctcatcc 2400acaggagtcg caacaacagc ttcagcacct gctgcagctg ctgcttccct acaagcagcc 2460gcagcagccg taccatcatc tccagcaaca ccaacttatt caggtgtagt aggaggagct 2520atctatggag aaaaggttac attctctcaa tgtagcggga cttgtcagtt ctctgggaac 2580caagctatcg ataacaatcc ctcccaatca tcgttgaacg tacaaggagg agccatctat 2640gccaaaacct ctttgtctat tggatcttcc gatgctggaa cctcctatat tttctcgggg 2700aacagtgtct ccactgggaa atctcaaaca acagggcaaa tagcgggagg agcgatctac 2760tcccctactg ttacattgaa ttgtcctgcg acattctcta acaatacagc ctctatggct 2820acaccaaaga cttcttctga agatggatcc tcaggaaatt ctattaaaga taccattgga 2880ggagccattg cagggacagc cattacccta tctggagtct ctcgattttc agggaatacg 2940gctgatttag gagctgcaat aggaactcta gctaatgcaa atacacccag tgcaactagc 3000ggatctcaaa atagcattac agaaaaaatt actttagaaa acggttcttt tatttttgaa 3060agaaaccaag ctaataaacg tggagcgatt tactctccta gcgtttccat taaagggaat 3120aatattacct tcaatcaaaa tacatccact catgatggaa gtgctatcta ctttacaaaa 3180gatgctacga ttgagtcttt aggatctgtt ctttttacag gaaataacgt tacagctaca 3240caagctagtt ctgcaacatc tggacaaaat acaaatactg ccaactatgg ggcagccatc 3300tttggagatc caggaaccac tcaatcgtct caaacagatg ccattttaac ccttcttgct 3360tcttctggaa acattacttt tagcaacaac agtttacaga ataaccaagg tgatactccc 3420gctagcaagt tttgtagtat tgcaggatac gtcaaactct ctctacaagc cgctaaaggg 3480aagactatta gctttttcga ttgtgtgcac acctctacca aaaaaatagg ttcaacacaa 3540aacgtttatg aaactttaga tattaataaa gaagagaaca gtaatccata tacaggaact 3600attgtgttct cttctgaatt acatgaaaac aaatcttaca tcccacagaa tgcaatcctt 3660cacaacggaa ctttagttct taaagagaaa acagaactcc acgtagtctc ttttgagcag 3720aaagaagggt ctaaattaat tatgaaaccc ggagctgtgt tatctaacca aaacatagct 3780aacggagctc tagttatcaa tgggttaacg attgatcttt ccagtatggg gactcctcaa 3840gcaggggaaa tcttctctcc tccagaatta cgtatcgttg ccacgacctc tagtgcatcc 3900ggaggaagcg gggtcagcag tagtatacca acaaatccta aaaggatttc tgcagcagcg 3960ccttcaggtt ctgccgcaac tactccaact atgagcgaga acaaagtttt cctaacagga 4020gaccttactt taatagatcc taatggaaac ttttaccaaa accctatgtt aggaagcgat 4080ctagatgtac cactaattaa gcttccgact aacacaagtg acgtccaagt ctatgattta 4140actttatctg gggatctttt ccctcagaaa gggtacatgg gaacctggac attagattct 4200aatccacaaa cagggaaact tcaagccaga tggacattcg atacctatcg tcgctgggta 4260tacataccta gggataatca tttttatgcg aactctatct taggctccca aaactcaatg 4320attgttgtga agcaagggct tatcaacaac atgttgaata atgcccgctt cgatgatatc 4380gcttacaata acttctgggt ttcaggagta ggaactttct tagctcaaca aggaactcct 4440ctttccgaag aattcagtta ctacagccgc ggaacttcag ttgccatcga tgccaaacct 4500agacaagatt ttatcctagg agctgcattt agtaagatgg tggggaaaac caaagccatc 4560aaaaaaatgc ataattactt ccataagggc tctgagtact cttaccaagc ttctgtctat 4620ggaggtaaat tcctgtattt cttgctcaat aagcaacatg gttgggcact tcctttccta 4680atacaaggag tcgtgtccta tggacatatt aaacatgata caacaacact ttacccttct 4740atccatgaaa gaaataaagg agattgggaa gatttaggat ggttagcgga tcttcgtatc 4800tctatggatc ttaaagaacc ttctaaagat tcttctaaac ggatcactgt ctatggggaa 4860cttgagtatt ccagcattcg ccagaaacag ttcacagaaa tcgattacga tccaagacac 4920ttcgatgatt gtgcttacag aaatctgtcg cttcctgtgg gatgcgctgt cgaaggagct 4980atcatgaact gtaatattct tatgtataat aagcttgcat tagcctacat gccttctatc 5040tacagaaata atcctgtctg taaatatcgg gtattgtctt cgaatgaagc tggtcaagtt 5100atctgcggag tgccaactag aacctctgct agagcagaat acagtactca actatatctt 5160ggtcccttct ggactctcta cggaaactat actatcgatg taggcatgta tacgctatcg 5220caaatgacta gctgcggtgc tcgcatgatc ttc 5253<210>422<211>1980<212>DNA<213>沙眼衣原体血清变型D<400>422atgagcgaaa aaagaaagtc taacaaaatt attggtatcg acctagggac gaccaactct 60tgcgtctctg ttatggaagg tggccaacct aaagttattg cctcttctga aggaactcgt 120actactcctt ctatcgttgc ttttaaaggt ggcgaaactc ttgttggaat tcctgcaaaa 180cgtcaggcag taaccaatcc tgaaaaaaca ttggcttcta ctaagcgatt catcggtaga 240aaattctctg aagtcgaatc tgaaattaaa acagtcccct acaaagttgc tcctaactcg 300aaaggagatg cggtctttga tgtggaacaa aaactgtaca ctccagaaga aatcggcgct 360cagatcctca tgaagatgaa ggaaactgct gaggcttatc tcggagaaac agtaacggaa 420gcagtcatta ccgtaccagc ttactttaac gattctcaaa gagcttctac aaaagatgct 480ggacgtatcg caggattaga tgttaaacgc attattcctg aaccaacagc ggccgctctt 540gcttatggta ttgataagga aggagataaa aaaatcgccg tcttcgactt aggaggagga 600actttcgata tttctatctt ggaaatcggt gacggagttt ttgaagttct ctcaaccaac 660ggggatactc acttgggagg agacgacttc gatggagtca tcatcaactg gatgcttgat 720gaattcaaaa aacaagaagg cattgatcta agcaaagata acatggcttt gcaaagattg 780aaagatgctg ctgaaaaagc aaaaatagaa ttgtctggtg tatcgtctac tgaaatcaat 840cagccattca tcactatcga cgctaatgga cctaaacatt tggctttaac tctaactcgc 900gctcaattcg aacacctagc ttcctctctc attgagcgaa ccaaacaacc ttgtgctcag 960gctttaaaag atgctaaatt gtccgcttct gacattgatg atgttcttct agttggcgga 1020atgtccagaa tgcctgcggt acaagcagtt gtaaaagaga tctttggtaa agagcctaat 1080aaaggcgtca atccagatga agttgtagcg attggagctg ctattcaggg tggtgtcctc 1140ggcggagaag tgaaagacgt tctgttgttg gatgtgattc ccctctcttt aggaattgag 1200actctaggtg gggtcatgac tcctttggta gagagaaaca ctacaatccc tactcagaag 1260aagcaaatct tctctacagc cgctgacaat cagccagcag tgactatcgt cgttcttcaa 1320ggtgaacggc ctatggcgaa agacaataag gaaattggaa gatttgatct aacagacatt 1380cctcctgctc ctcgcggcca tccacaaatt gaggtaacct tcgatattga tgccaacgga 1440attttacacg tttctgctaa agatgctgct agtggacgcg aacaaaaaat ccgtattgaa 1500gcaagctctg gattaaaaga agatgaaatt caacaaatga tccgcgatgc agagcttcat 1560aaagaggaag acaaacaacg aaaagaagct tctgatgtga aaaatgaagc cgatggaatg 1620atctttagag ccgaaaaagc tgtgaaagat taccacgaca aaattcctgc agaacttgtt 1680aaagaaattg aagagcatat tgagaaagta cgccaagcaa tcaaagaaga tgcttccaca 1740acagctatca aagcagcttc tgatgagttg agtactcata tgcaaaaaat cggagaagct 1800atgcaggctc aatccgcatc cgcagcagca tcttctgcag cgaatgctca aggagggcca 1860aacattaact ccgaagatct gaaaaaacat agtttcagca cacgacctcc agcaggagga 1920agcgcctctt ctacagacaa cattgaagat gctgatgttg aaattgttga taaacctgag 1980<210>423<211>978<212>DNA<213>沙眼衣原体血清变型D<400>423atggtttctc aaacagtgag tgtagcagta acaggaggaa cagggcaaat agcctatagc 60tttctatttt ctctggctca tggagatgtt tttggccttg attgtggcat cgatctgcgt 120atctacgata ttcctggaac agaaagggct ttatctggtg tgcgcatgga gctagatgat 180ggtgctttcc ctttattaca gcgtgtgcag gtaacgacat cattgcatga tgcttttgat 240ggcattgatg cggcattcct tatagggtca gttcctagag gcccaggaat ggagagaaga 300gatcttctaa agaaaaatgg ggagattttt gctacgcaag gaaaagcttt gaacacaaca 360gccaagcggg atgcaaagat ttttgttgtt gggaaccctg tgaataccaa ttgctggata 420gcaatgaatc atgctcccag attattgaga aagaactttc atgcgatgct acgattggac 480cagaatcgta tgcatagcat gttatcgcat agagcagaag tacctttatc ggctgtatca 540caagttgtgg tttggggaaa tcactccgcc aaacaagtgc ctgattttac gcaagctctg 600attaatgacc gtcctatcgc agagacgata gcggatcgtg attggttaga gaatattatg 660gtgccttctg tacagagtcg tggtagtgca gtaatcgaag cacgagggaa gtcttcggca 720gcttctgcag cacgagcttt agcagaggct gctcgatcaa tatatcagcc aaaagaagga 780gaatggtttt cttccggagt gtgttcggac cacaatccct atggattacc ggaagattta 840atctttggtt tcccttgtcg aatgctagca acgggagaat atgaagtgat tccaaggctt 900ccttgggatg cctttatccg tgggaaaatg caaatatctc ttgatgagat tcttcaggaa 960aaagctagcg tatctttg 978<210>424<211>696<212>DNA<213>沙眼衣原体血清变型D<400>424atgacaaagc atggaaaacg cattcgtggt atccaagaga cttacgattt agctaagtcg 60tattctttgg gtgaagcgat agatatttta aaacagtgtc ctactgtgcg tttcgatcaa 120acggttgatg tgtctgttaa attagggatc gatccaagaa agagtgatca gcaaattcgt 180ggttcggttt ctttacctca cggtacaggt aaagttttgc gaattttagt ttttgctgct 240ggagataagg ctgcagaggc tattgaagca ggagcggact ttgttggtag cgacgactta 300gtagagaaaa tcaaaggtgg atgggttgac ttcgatgttg cggttgccac tcccgatatg 360atgagagagg tcggaaagct aggaaaagtt ttgggtccaa gaaaccttat gcctacgcct 420aaagccggaa ctgtaacaac agatgtggtt aaaactgttg cggaactgcg aaaaggtaaa 480attgaattta aagctgatcg agctggtgta tgcaacgtcg gagttgcgaa gctttctttc 540gatagtgcgc aaatcaaaga aaatgtcgaa gcgttgtgtg cagccttagt taaagctaaa 600cccgcaactg ctaaaggaca atatttagtt aatttcacta tttcctcgac catggggcca 660ggggttaccg tggatactag ggagttgatt gcgtta 696<210>425<211>3756<212>DNA<213>沙眼衣原体血清变型D<400>425atgttcaagt gcccggagcg ggtcagcatc aaaaagaaag aagatatttt agatcttcct 60aatcttgtcg aagttcaaat caagtcgtat aagcagtttc ttcaaatcgg gaagcttgct 120gaagagcgag aaaacattgg tttagaagaa gtcttcagag aaattttccc tatcaagtct 180tataatgaag ctacgatttt agagtacctc tcttataact taggagtgcc caaatactcc 240ccagaagagt gtattcgtcg gggaatcacc tatagtgtta ctttaaaggt tcgtttccgt 300ttaactgatg aaacggggat taaagaagaa gaagtctata tgggaaccat ccccatcatg 360actgataagg gaacctttat tattaatggg gcagagagag tcgttgtttc tcaagtccac 420cgttctccag gaatcaattt tgaacaagaa aaacattcta aaggaaatgt tttattttct 480tttagaatta ttccttatcg aggaagttgg ttagaagctg tcttcgacat taatgacctt 540atctatatcc atattgatag gaaaaaacgt cgcagaaaga ttttagctat gacgtttatc 600cgagctttag gatattcaac agatgcagat attattgaag agttcttttc tgtagaggag 660cgttccttac gtttagagaa ggattttgtc gcgttagttg gtaaagtttt agctgataac 720gtagttgatg cggattcttc attagtttac gggaaagctg gagagaagct aagtactgct 780atgctaaaac gcatcttaga tgcgggagtc caatctttga agattgctgt tggcgcagat 840gaaaatcacc caattattaa gatgctcgca aaagatccta cggattctta cgaagctgct 900cttaaagatt tttatcgcag attacgacca ggagagcctg caactttagt taatgctcga 960tccacaatta tgcgcttatt cttcgatgct aaacgctata atttaggccg cgttggacgt 1020tataaattaa ataaaaaatt aggattccca ttagacgacg aaacattatc tcaagtgact 1080ttgagaaaag aagatgttat cggcgcgttg aaatatttga ttcgtttgcg aatgggcgat 1140gagaagacat ctatcgatga tattgaccat ttggcaaacc gacgagttcg ctctgttgga 1200gaactaattc agaatcactg tcgttctgga ttggctagaa tggaaaagat cgttcgagaa 1260agaatgaatc tctttgattt ctcttctgat accctaactc caggaaagat tatttctgct 1320aaagggttag tcagtgtcct gaaagatttc ttcagccgtt ctcaattatc tcagtttatg 1380gatcagacaa accctgtcgc agaattgacg cacaagcgtc gtctgtcagc attaggacct 1440gggggattga atagagaaag agctgggttt gaagttcgag acgttcacgc aagccactat 1500ggtagaattt gtccaattga gactcctgaa ggaccaaaca ttgggttgat tacttcactg 1560tcttcctttg ctaagatcaa tgaatttgga ttcatagaga ctccttatcg tgtcgtgcgc 1620gatggcatcg tgacagatga aattgagtat atgacagcag atgttgaaga agagtgtgtc 1680attgctcagg cttctgcgga gctcgatgag tatgatatgt ttaaaactcc cgtatgctgg 1740gctagataca aaggagaggc ttttgaagcc gacacaagta cggttacgca tatggacgtt 1800tctccaaaac agctggtatc tgtggttacg gggctgattc ctttcttgga acacgacgat 1860gctaaccgag ctcttatggg atcgaacatg caacggcagg ctgtaccatt attgaaaacg 1920gaagctgcta ttgttggaac tggattagaa gggcgtgctg ccaaagattc tggagctatt 1980attgtggctc aggaagatgg ggtagtcgaa tacgtagata gctatgagat tgtcgtagcg 2040aagaagaata atccaacgct taaggatcgt tatcagctta aaaaattctt aagatccaac 2100tccggaacat gcatcaacca aactcctttg tgttctgtgg gagatgtggt tacgcatgga 2160gatgttttag cggatggccc agcaaccgat aaaggggaat tggctcttgg taaaaacgta 2220ttagtagcct tcatgccttg gtacgggtat aacttcgaag atgcgattat catctccgag 2280aggttgatta aacaagatgc gtacacttct atttacatag aagaatttga gttaacagct 2340cgagatacaa aactcggtaa agaagaaatt actagagata ttcctaacgt ttctgaagag 2400gttttggcaa atctcggaga ggatggtgtc gtccgtattg gggctgaagt caagccggga 2460gatattcttg tcggtaaaat cactccgaaa tctgagacgg aactagctcc tgaagagcgt 2520ttgttgcgag ctatttttgg agagaaggcg gcggacgtaa aagatgcctc tctaacggtt 2580cctcctggta cagaaggagt cgtaatggat gtcaaagtat tcagcagaaa ggatcgcttg 2640tccaagagcg atgatgaact ggttgaagaa gctgtgcatc ttaaggatct acagaaagaa 2700tataagagtc agttagctca attgaaagta gaacatagag agaaactggg ggctctattg 2760ctcaatgaaa aagctcctgc agcgattata caccgtcgtt cggcagatat tttggttcaa 2820gaaggtgcta tttttgatca agagactatc gaactcttag aaagagagtc gctagttgat 2880ttgctgatgg ctccttgtga catgtatgat gttttgaaag atattctttc tagctatgaa 2940acagctgttc agcgtttgga agtcaattat aaaaccgaag ctgagcacat aaaagaaggt 3000gatgctgact tagatcatgg agttatccga caagttaaag tttacgtggc ttccaagcga 3060aaacttcaag ttggggataa aatggctgga cgtcacggaa acaagggagt ggtttccaag 3120attgttccag aagcagacat gcctttctta gctaacggtg aaacagtaca gatgattttg 3180aacccgttag gggtgccttc tcgaatgaac cttggacagg ttttagagac acatttagga 3240tatgctgcaa aaactgcagg tatctatgtg aaaactccgg tctttgaagg gttcccagag 3300tctcgtattt gggatatgat gatagagcag ggattgcccg aagatggtaa gtcttaccta 3360tttgatggta aaaccggaga gcgtttcgat agcaaagtgg tcgttggata catctacatg 3420ttgaaattga gtcacttaat tgctgataag atccacgctc gttctatagg accttactct 3480ctcgttacgc agcaacctct tggaggtaaa gcgcagatgg gaggacagag attcggggaa 3540atggaggtat gggctttaga ggcgtatggg gtagctcata tgttacaaga gattctgact 3600gttaagtccg acgatgtttc gggaagaact cgtatctacg aatcaatcgt gaaaggagaa 3660aacttacttc gttctggaac gcctgagtcg ttcaacgttt tgattaaaga aatgcaaggt 3720ctagggcttg atgttcgccc tatggtagta gatgct 3756<210>426<211>894<212>DNA<213>沙眼衣原体血清变型D<400>426atgttgaaaa ttgatttaac aggaaaaatt gctttcatag ccggcatagg cgatgataac 60gggtatggct ggggcattgc caaaatgtta gcagaagcag gcgcaaccat acttgtgggg 120acctgggttc ctatctataa aattttctct caatctttgg agttaggaaa attcaatgca 180tctcgtgaac tctccaatgg agaattgcta actttcgcta aaatctatcc catggatgcc 240agtttcgaca ccccagaaga tattcctcag gaaattttgg aaaataaacg ttacaaagat 300ctttctgggt acactgtatc cgaagttgta gaacaggtga aaaaacattt tggacacatt 360gatattcttg ttcactcttt agcaaacagt ccggaaattg ctaaaccatt acttgatacc 420tctcgtaaag gctatcttgc cgccttaagt acatccagct actcctttat cagccttctc 480tctcattttg gcccaattat gaatgcagga gctagcacca tctctctaac ttatcttgct 540tccatgcgtg ctgttccagg gtatggcgga ggaatgaacg cagcaaaagc tgctttagaa 600agtgatacaa aagtactggc ttgggaagcc ggccgacgtt ggggagtccg agtgaatact 660atctcggcag ggccattagc tagccgtgca ggaaaagcta ttggatttat tgagagaatg 720gtggattact accaagactg ggctccacta ccttctccaa tggaagctga gcaagtaggc 780gcagcagcag ccttcttagt ctctccccta gctagcgcaa ttacgggaga aactctctat 840gtggatcacg gagccaatgt gatgggcata ggtccagaaa tgtttcctaa ggat 894<210>427<211>894<212>DNA<213>沙眼衣原体血清变型D<400>427atgagtttac agaagttatt agttacagac attgacggga caattacaca tcaatcccac 60ctacttcatg atcgtgttgt aaaggctttg catcaatact atgattctgg ttggcagtta 120ttttttctaa ctggcagata tttttcttat gcatatcctc tttttcaaaa cttttcggtt 180ccttttctat taggtagcca gaatggttct tccgtgtggt cctccacgga taaagagttt 240atttattttc gtagcttgtc tcgagatttt ctatatgttt tagagaaata ttttgaagat 300ttagatctca ttgcctgtat agaatctgga gcctctaatc gtgatgtata ctttcgaaag 360ggattaggga aaacatctca ggaactcaaa gcgattcttg atgctgtgta ttttcctaca 420ccagaagctg cgcgactgct ggtggatgtt cagggacatt tatcagaaga attttcttat 480gaagattttg ccattgccaa atttttcggt gagagagagg aagtgaagaa aattatggat 540agatttattc aatctccaga agtttcttca caggtaacca tgaattacat gcgttggcct 600tttgatttca aatacgcagt gcttttactt actttaaaag atgtttcaaa aggttttgct 660gtagatcaag ttgttcagac cttctataaa gagaataagc cttttattat ggcttctggg 720gatgatgcta acgatatcga cctgctatct cgaggagatt ttaaaattgt tatacagacg 780gctccagagg agatgcatgg attagcggac tttttggctc ccccggcgaa ggattttggt 840attctctccg cctgggaagc tggtgagctg cgttacaaac agctagttaa tcct 894<210>428<211>459<212>DNA<213>沙眼衣原体血清变型D<400>428atgttgcgct tgtttcaaca tatattgtgt tttttagaag aagacccttc gtttgtagac 60gtccctcaag agctttcttt tgtcaatgaa gctttctctg gttctatgcg ttgggaagta 120ggtaggatgc taggctcttt acttctcctg ttagggatat ttggaggggg gtgtttgcta 180tttcgacgtt ttttgcgttc ccgcggacat cttcctagcg gcaattcgtc cattaagatt 240ttggatcaac gggttttggc ttcaaaaacc tccatctatg tgattaaagt agcgaacaag 300actttagttg ttgctgagag aggagagcga gtgaccttat tatctgaatt tcctccgaat 360acagatctta atgagctaat acagaaggat caaaaaaaac cttcgactcc tcgaggggag 420atgctttcag gtttcttaaa gcaatttaaa gaaaagaaa 459<210>429<211>1707<212>DNA<213>沙眼衣原体血清变型D<400>429atgccaaaac aagctgatta tacttgggga gcaaaaaaga atctcgatac gatagcttgc 60ttaccagaag acgttaaaca atttaaagac cttctctacg cgatgtatgg cttcaccgcg 120acagaagaag aacccactag cgaagtacat cctggtgcga tcctaaaagg tacagttgtt 180gacataagca aagactttgt tgttgtagat gtcggcttaa aatctgaggg agttattcct 240atgtctgagt ttatcgactc ttcagaaggt ttaactgtcg gagccgaagt cgaagtttac 300ctagaccaaa ctgaggatga cgaaggaaaa gttgttttat ccagagaaaa agcaacaaga 360caacgacaat gggaatacat tcttgctcac tgcgaggaag gttctattgt taagggacaa 420attacccgaa aagttaaggg tggtttgatc gtagatattg gtatggaagc cttccttcca 480ggatcccaaa tagacaataa gaagatcaag aacttagatg attacgtagg caaggtttgt 540gagttcaaaa ttctcaaaat caacgtagat cgtcggaacg ttgttgtatc tagaagagaa 600cttctcgaag ctgaacgcat ttctaagaaa gcagagttga tcgagcaaat cactatcggt 660gagcgtcgca aaggtatcgt taagaatatc acagatttcg gagtattctt ggatcttgat 720ggcattgacg gcctactcca cattacagac atgacatgga aacgcattcg tcacccatcc 780gaaatggttg aactcaacca agaattggaa gtcatcatcc ttagcgttga taaagaaaaa 840ggtcgcgtag ctcttggcct caaacaaaaa gagcataatc cttgggaaga tattgagaag 900aaatatcctc caggaaaacg tgttcgcgga aaaattgtta aactccttcc ttatggagca 960tttattgaaa tcgaagaagg aattgaaggc cttattcacg tttcagagat gtcttgggtt 1020aagaacattg tagatcctaa tgaagtggtc aacaaaggtg atgaagtcga agtagttgtt 1080ctttctatcc aaaaagatga aggaaaaatc tctctcggtc tcaaacaaac aaaacacaat 1140ccttgggata acattgaaga aaaatatcct atcggcctcc gcgtaacagc agaaattaaa 1200aatctgacaa actacggagc tttcgttgag ttggagccag gaatcgaagg tttgatccat 1260atctctgaca tgagttggat taaaaaagtt tcccatcctt cagagctctt caaaaaaggt 1320aataccgtcg aagcagttat tctgtctgta gacaaagaaa gcaaaaaaat cactttgggc 1380gtgaaacaat taactcctaa tccatgggat gagattgaag ttatgttccc tgtcggaagt 1440gatatctctg gcgtagtaac taaaattacg gctttcggag ctttcgttga gttgcaaaat 1500ggtatcgaag gactgatcca tgtatccgag ctttcagaga aaccttttgc taaaattgaa 1560gatgttctct ctattggaga caaagtttct gctaaagtta tcaagctaga cccagatcac 1620aagaaagttt ctctttctat taaagagttc cttgttcatg ggggagatgc tggtcacgat 1680gcggaagaag aatcttctga cagagac 1707<210>430<211>1998<212>DNA<213>沙眼衣原体血清变型D<400>430atggaatctt tgtctgttcg ttccactatc cctttacctc taggagccaa aaagctctcc 60gctgatcgct accgtttttc tctattttct tcacaagccc agcaggttac tcttgtacta 120ttagaccctc tttctgaaat tcatgaaatt cctctatctt ctaccgacca caggactgga 180gccatctggc atatcgaaat tgcaggcatt tctagtgaat ggtcgtatgc ttataaacta 240cgtggtacag acttgagctc tcaaaagttt gctacagatt cttacatcgc agacccttat 300tctaagaata tctactcccc tcaactattt ggatccccta aacaagaaaa ggattacgca 360tttagttacc tgaaacatga ggattttgac tgggaaggcg acactccttt gcaccttcca 420aaagaaaatt acttcattta tgaaatgcat gttcggtcat tcacccgaga tccgtcttcc 480caggtttccc atcctggaac tttccttggt attatcgaaa aaatagacca cctcaaacaa 540ctaggcgttc atgcagttga actccttcct attttcgaat tcgatgaaac cgtccatcca 600tttaaaaatc aggacttccc ccacctgtgt aactattggg ggtattcttc ggtgaatttt 660ttctgcccct ctcgccgtta tacttatggg gcagaccctt gcgctccggc ccgagagttc 720aagactcttg tcaaagcatt acaccgtgcg ggaatcgaag tcattctcga tgtcgttttc 780aatcatacag gctttgaagg cacaagctgc cctcttccct ggatagatct agaatcctat 840tatatggtca atgatcatgg ggatctcatg aatttctccg ggtgtggtaa tacagtcaat 900accaacaccc ccactactct gaaatggatt cttgatgctt tgcggtactg ggtacaggaa 960atgcacgtag atggatttcg ttttgattta gcctcagtct tctctagaga tccacaagga 1020gtccctctcc ctttaacccc cattttgcaa gctatatcct ctgattccat tttatcagaa 1080actaaactga tcgctgaacc ttgggacgct ggaggtttgt atcagcttgg acacttcccc 1140tctatatcaa cccgatggag cgagtggaat ggatgctacc gtgaccatgt aaaagccttc 1200ctgaatggag atgctcatca agtaagttcc tttgcttcac gaatatctgg atctcatgac 1260atctatccca atgggaaacc tacgaactcg attaactata tctgctctca tgatggcttc 1320acactctacg atactgttgc ctataacgat aagcacaatg aagagaatgg tgaatacaat 1380cgtgatggga cttcagcaaa ctatagctat aactttggct gcgaaggaga aacgacagat 1440cccaccattt gcgctctacg tgaacgccaa atgaaaaact tctttcttgc tctcttttta 1500tctcaaggaa ttcccatgat acaatccgga gatgaatatg ggcacacagc ttatggaaat 1560aataatcact ggtgcttaga cacaaagatc aattactttc tttgggatcg attagctgaa 1620aggaaagaac tgttttcttt cttatgccaa gtcattgctc tgcgcaaagc ttataccgaa 1680ttattcaata cctctttctt atcagaagat acgattacct ggctaaatac aaaaggttct 1740cccagagagt ggggagccga tcattatcta gcttttgagt tgaaacacct gaactacagt 1800ttattcgtag cgttttatag tgggaatgaa cgtattgaga tctctttacc taaacctaga 1860aaagaacatt tggcctatga aaaaattgta gatagcacaa caggattctt ttctcagata 1920ttatctccca aactctctct tgaaccttat agctctttgg tagccatcag cagaagaaaa 1980acctccttgg aatctaga 1998<210>431<211>609<212>PRT<213>沙眼衣原体血清变型D<400>431Met Gly Phe Trp Arg Thr Ser Ile Met Lys Met Asn Arg Ile Trp Leu

5 10 15Leu Leu Leu Thr Phe Ser Ser Ala Ile His Ser Pro Val Gln Gly Glu

20 25 30Ser Leu Val Cys Lys Asn Ala Leu Gln Asp Leu Ser Phe Leu Glu His

35 40 45Leu Leu Gln Val Lys Tyr Ala Pro Lys Thr Trp Lys Glu Gln Tyr Leu

50 55 60Gly Trp Asp Leu Val Gln Ser Ser Val Ser Ala Gln Gln Lys Leu Arg65 70 75 80Thr Gln Glu Asn Pro Ser Thr Ser Phe Cys Gln Gln Val Leu Ala Asp

85 90 95Phe Ile Gly Gly Leu Asn Asp Phe His Ala Gly Val Thr Phe Phe Ala

100 105 110Ile Glu Ser Ala Tyr Leu Pro Tyr Thr Val Gln Lys Ser Ser Asp Gly

115 120 125Arg Phe Tyr Phe Val Asp Ile Met Thr Phe Ser Ser Glu Ile Arg Val

130 135 140Gly Asp Glu Leu Leu Glu Val Asp Gly Ala Pro Val Gln Asp Val Leu145 150 155 160Ala Thr Leu Tyr Gly Ser Asn His Lys Gly Thr Ala Ala Glu Glu Ser

165 170 175Ala Ala Leu Arg Thr Leu Phe Ser Arg Met Ala Ser Leu Gly His Lys

180 185 190Val Pro Ser Gly Arg Thr Thr Leu Lys Ile Arg Arg Pro Phe Gly Thr

195 200 205Thr Arg Glu Val Arg Val Lys Trp Arg Tyr Val Pro Glu Gly Val Gly

210 215 220Asp Leu Ala Thr Ile Ala Pro Ser Ile Arg Ala Pro Gln Leu Gln Lys225 230 235 240Ser Met Arg Ser Phe Phe Pro Lys Lys Asp Asp Ala Phe His Arg Ser

245 250 255Ser Ser Leu Phe Tyr Ser Pro Met Val Pro His Phe Trp Ala Glu Leu

260 265 270Arg Asn His Tyr Ala Thr Ser Gly Leu Lys Ser Gly Tyr Asn Ile Gly

275 280 285Ser Thr Asp Gly Phe Leu Pro Val Ile Gly Pro Val Ile Trp Glu Ser

290 295 300Glu Gly Leu Phe Arg Ala Tyr Ile Ser Ser Val Thr Asp Gly Asp Gly305 310 315 320Lys Ser His Lys Val Gly Phe Leu Arg Ile Pro Thr Tyr Ser Trp Gln

325 330 335Asp Met Glu Asp Phe Asp Pro Ser Gly Pro Pro Pro Trp Glu Glu Phe

340 345 350Ala Lys Ile Ile Gln Val Phe Ser Ser Asn Thr Glu Ala Leu Ile Ile

355 360 365Asp Gln Thr Asn Asn Pro Gly Gly Ser Val Leu Tyr Leu Tyr Ala Leu

370 375 380Leu Ser Met Leu Thr Asp Arg Pro Leu Glu Leu Pro Lys His Arg Met385 390 395 400Ile Leu Thr Gln Asp Glu Val Val Asp Ala Leu Asp Trp Leu Thr Leu

405 410 415Leu Glu Asn Val Asp Thr Asn Val Glu Ser Arg Leu Ala Leu Gly Asp

420 425 430Asn Met Glu Gly Tyr Thr Val Asp Leu Gln Val Ala Glu Tyr Leu Lys

435 440 445Ser Phe Gly Arg Gln Val Leu Asn Cys Trp Ser Lys Gly Asp Ile Glu

450 455 460Leu Ser Thr Pro Ile Pro Leu Phe Gly Phe Glu Lys Ile His Pro His465 470 475 480Pro Arg Val Gln Tyr Ser Lys Pro Ile Cys Val Leu Ile Asn Glu Gln

485 490 495Asp Phe Ser Cys Ala Asp Phe Phe Pro Val Val Leu Lys Asp Asn Asp

500 505 510Arg Ala Leu Ile Val Gly Thr Arg Thr Ala Gly Ala Gly Gly Phe Val

515 520 525Phe Asn Val Gln Phe Pro Asn Arg Thr Gly Ile Lys Thr Cys Ser Leu

530 535 540Thr Gly Ser Leu Ala Val Arg Glu His Gly Ala Phe Ile Glu Asn Ile545 550 555 560Gly Val Glu Pro His Ile Asp Leu Pro Phe Thr Ala Asn Asp Ile Arg

565 570 575Tyr Lys Gly Tyr Ser Glu Tyr Leu Asp Lys Val Lys Lys Leu Val Cys

580 585 590Gln Leu Ile Asn Asn Asp Gly Thr Ile Ile Leu Ala Glu Asp Gly Ser

595 600 605Phe<210>432<211>268<212>PRT<213>沙眼衣原体血清变型D<400>432Met Pro Pro Arg Ser Pro Ser Phe Leu Val His Ile Trp Arg Leu Phe

5 10 15Phe Ala Lys Gly Pro Asn Tyr Ser Leu Pro Tyr Ala Phe Leu Cys Ile

20 25 30Phe Val Ser Val Leu Val Phe Leu Pro Ile Gly Leu Trp Leu Thr Leu

35 40 45Pro Ser Phe Leu Asn Phe Lys His Ser Leu Thr Pro Ile Lys Thr Leu

50 55 60Phe Leu Thr Cys Thr Glu Pro Pro Cys Leu Pro Glu Pro Phe Phe Ser65 70 75 80Asp Ile Leu His Leu Ser Ala Asp Ser Pro Pro Ala Leu Gln Thr Phe

85 90 95Ser Thr Lys Ser Ala Glu His Phe Leu Asn Glu Leu Gly Val Phe Ser

100 105 110Phe Ile Ser Ile Glu Lys Val Pro Asp His Lys Gly Leu Ala Ile Ser

115 120 125Tyr Ala Leu His Thr Pro Leu Ala Phe Leu Gly Asn Gln Thr His Thr

130 135 140Phe Ile Gly Tyr Glu Gly Gln Thr Phe Pro Ala Leu Pro Phe Phe Gln145 150 155 160Ser Leu Glu Leu Pro Thr Val Phe Phe Ser Gln Gln Ala Leu Ser Gln

165 170 175Thr Arg Ile Pro His Gln Thr Leu Ser Ile Val Thr Ser Leu Ile Asp

180 185 190Gln Leu Gln Met Asp Pro Pro Ser Ile Ile Asp Leu Ser Gln Ile Asp

195 200 205His Tyr Pro Gly Glu Phe Val Val Ser Leu Ser Ser Gly Thr Leu Leu

210 215 220Arg Phe Arg Lys Asp Ser Phe Leu Pro Gly Ile Gln His Tyr Gln Gln225 230 235 240Ala Leu Ser Leu Gly Ala Phe Ser Pro Gln Gln Ala Val Ile Cys Asp

245 250 255Leu Arg Cys Glu Asp Tyr Leu Leu Leu Lys Arg Lys

260 265<210>433<211>221<212>PRT<213>沙眼衣原体血清变型D<400>433Met Lys Lys Phe Ile Tyr Lys Tyr Ser Phe Gly Ala Leu Leu Leu Leu

5 10 15Ser Gly Leu Ser Gly Leu Ser Ser Cys Cys Ala Asn Ser Tyr Gly Ser

20 25 30Thr Leu Ala Lys Asn Thr Ala Glu Ile Lys Glu Glu Ser Val Thr Leu

35 40 45Arg Glu Lys Pro Asp Ala Gly Cys Lys Lys Lys Ser Ser Cys Tyr Leu

50 55 60Arg Lys Phe Phe Ser Arg Lys Lys Pro Lys Glu Lys Thr Glu Pro Val65 70 75 80Leu Pro Asn Phe Lys Ser Tyr Ala Asp Pro Met Thr Asp Ser Glu Arg

85 90 95Lys Asp Leu Ser Phe Val Val Ser Ala Ala Ala Asp Lys Ser Ser Ile

100 105 110Ala Leu Ala Met Ala Gln Gly Glu Ile Lys Gly Ala Leu Ser Arg Ile

115 120 125Arg Glu Ile His Pro Leu Ala Leu Leu Gln Ala Leu Ala Glu Asp Pro

130 135 140Ala Leu Ile Ala Gly Met Lys Lys Met Gln Gly Arg Asp Trp Val Trpl45 150 155 160Asn Ile Phe Ile Thr Glu Leu Ser Lys Val Phe Ser Gln Ala Ala Ser

165 170 175Leu Gly Ala Phe Ser Val Ala Asp Val Ala Ala Phe Ala Ser Thr Leu

180 185 190Gly Leu Asp Ser Gly Thr Val Thr Ser Ile Val Asp Gly Glu Arg Trp

195 200 205Ala Glu Leu Ile Asp Val Val Ile Gln Asn Pro Ala Ile

210 215 220<210>434<211>490<212>PRT<213>沙眼衣原体血清变型D<400>434Met Ser Asp Leu Ser Asp Leu Phe Lys Thr His Phe Thr Gln Tyr Ala

5 10 15Ser Tyr Val Ile Leu Glu Arg Ala Ile Pro His Val Leu Asp Gly Leu

20 25 30Lys Pro Val Gln Arg Arg Leu Leu Trp Thr Leu Phe Arg Met Asp Asp

35 40 45Gly Lys Met His Lys Val Ala Asn Ile Ala Gly Arg Thr Met Ala Leu

50 55 60His Pro His Gly Asp Ala Pro Ile Val Glu Ala Leu Val Val Leu Ala 65 70 75 80Asn Lys Gly Phe Leu Ile Glu Thr Gln Gly Asn Phe Gly Asn Pro Leu

85 90 95Thr Gly Asp Pro His Ala Ala Ala Arg Tyr Ile Glu Ala Arg Leu Ser

l00 105 110Pro Leu Ala Lys Glu Val Leu Phe Asn Thr Asp Leu Met Thr Phe His

115 120 125Asp Ser Tyr Asp Gly Arg Glu Gln Glu Pro Asp Ile Leu Ala Ala Lys

130 135 140Ile Pro Leu Leu Leu Leu His Gly Val Asp Gly Ile Ala Val Gly Met145 150 155 160Thr Thr Lys Ile Phe Pro His Asn Phe Cys Asp Leu Leu Glu Ala Gln

165 170 175Ile Ala Ile Leu Asn Asp Gln Pro Phe Ser Leu Leu Pro Asp Phe Pro

180 185 190Pro Gly Gly Thr Met Asp Ala Ser Asp Tyr Gln Asp Gly Leu Gly Ser

195 200 205Ile Val Leu Arg Ala Thr Ile Asp Ile Ile Asn Asp Lys Thr Leu Leu

210 215 220Ile Lys Glu Ile Cys Pro Ser Thr Thr Thr Glu Thr Leu Ile Arg Ser225 230 235 240Ile Glu Asn Ala Ala Lys Arg Gly Ile Ile Lys Ile Asp Ser Ile Gln

245 250 255Asp Phe Ser Thr Asp Leu Pro His Ile Glu Ile Lys Leu Pro Lys Gly

260 265 270Ile Tyr Ala Lys Asp Leu Leu Arg Pro Leu Tyr Thr His Thr Glu Cys

275 280 285Gln Val Ile Leu Thr Ser Arg Pro Thr Ala Ile Tyr Gln Gly Lys Pro

290 295 300Trp Glu Thr Thr Ile Ser Glu Ile Leu Arg Leu Gln Thr Lys Thr Leu305 310 315 320Gln Asn Tyr Leu Lys Lys Glu Leu Leu Ile Leu Glu Asp Ser Leu Ser

325 330 335Arg Glu Leu Tyr His Lys Thr Leu Glu Tyr Leu Phe Ile Lys His Lys

340 345 350Leu Tyr Asp Thr Val Arg Ser Met Leu Ser Lys Arg Lys Thr Ser Pro

355 360 365Ser Ser Ser Thr Ile His Asn Ala Val Leu Glu Ala Leu Thr Pro Phe

370 375 380Leu Asp Thr Leu Pro Ala Pro Asp Lys Gln Ala Thr Ala Gln Leu Ala385 390 395 400Ala Leu Thr Ile Lys Lys Ile Leu Cys Phe Asp Glu Asn Ser Tyr Glu

405 410 415Lys Glu Leu Ala Cys Leu Glu Lys Lys Arg Ser Ser Val Gln Lys Asp

420 425 430Leu Ser Gln Leu Lys Lys Tyr Thr Val Leu Tyr Ile Lys Lys Leu Leu

435 440 445Glu Thr Tyr Arg Gln Leu Gly His Arg Lys Thr Lys Ile Ala Lys Phe

450 455 460Asp Asp Leu Pro Thr Glu Arg Val Ser Ala His Lys Lys Ala Lys Glu465 470 475 480Leu Ala Ala Leu Asp Gln Glu Glu Asn Phe

485 490<210>435<211>78<212>PRT<213>沙眼衣原体血清变型D<400>435Met Lys Glu Phe Leu Ala Tyr Ile Val Lys Asn Leu Val Asp Lys Pro

5 10 15Glu Glu Val His Leu Lys Glu Val Gln Gly Thr Asn Thr Ile Ile Tyr

20 25 30Glu Leu Thr Val Ala Lys Gly Asp Ile Gly Lys Ile Ile Gly Lys Glu

35 40 45Gly Arg Thr Ile Lys Ala Ile Arg Thr Leu Leu Val Ser Val Ala Ser

50 55 60Arg Asp Asn Val Lys Val Ser Leu Glu Ile Met Glu Glu Arg65 70 75<210>436<211>647<212>PRT<213>沙眼衣原体血清变型D<400>436Met Glu Ser Gly Pro Glu Ser Val Ser Ser Asn Gln Ser Ser Met Asn

5 10 15Pro Ile Ile Asn Gly Gln Ile Ala Ser Asn Ser Glu Thr Lys Glu Ser

20 25 30Thr Lys Glu Ser Glu Ala Ser Pro Ser Ala Ser Ser Ser Val Ser Ser

35 40 45Trp Ser Phe Leu Ser Ser Ala Lys His Ala Leu Ile Ser Leu Arg Asp

50 55 60Ala Ile Leu Asn Lys Asn Ser Ser Pro Thr Asp Ser Leu Ser Gln Leu 65 70 75 80Glu Ala Ser Thr Ser Thr Ser Thr Val Thr Arg Val Ala Ala Arg Asp

85 90 95Tyr Asn Glu Ala Lys Ser Asn Phe Asp Thr Ala Lys Ser Gly Leu Glu

100 105 110Asn Ala Thr Thr Leu Ala Glu Tyr Glu Thr Lys Met Ala Asp Leu Met

115 120 125Ala Ala Leu Gln Asp Met Glu Arg Leu Ala Lys Gln Lys Ala Glu Val

130 135 140Thr Arg Ile Lys Glu Ala Leu Gln Glu Lys Gln Glu Val Ile Asp Lys145 150 155 160Leu Asn Gln Leu Val Lys Leu Glu Lys Gln Asn Gln Thr Leu Lys Glu

165 170 175Thr Leu Thr Thr Thr Asp Ser Ala Asp Gln Ile Pro Ala Ile Asn Ser

180 185 190Gln Leu Glu Ile Asn Lys Asn Ser Ala Asp Gln Ile Ile Lys Asp Leu

195 200 205Glu Gly Gln Asn Ile Ser Tyr Glu Ala Val Leu Thr Asn Ala Gly Glu

210 215 220Val Ile Lys Ala Ser Ser Glu Ala Gly Ile Lys Leu Gly Gln Ala Leu225 230 235 240Gln Ser Ile Val Asp Ala Gly Asp Gln Ser Gln Ala Ala Val Leu Gln

245 250 255Ala Gln Gln Asn Asn Ser Pro Asp Asn Ile Ala Ala Thr Lys Lys Leu

260 265 270Ile Asp Ala Ala Glu Thr Lys Val Asn Glu Leu Lys Gln Glu His Thr

275 280 285Gly Leu Thr Asp Ser Pro Leu Val Lys Lys Ala Glu Glu Gln Ile Ser

290 295 300Gln Ala Gln Lys Asp Ile Gln Glu Ile Lys Pro Ser Gly Ser Asp Ile305 310 315 320Pro Ile Val Gly Pro Ser Gly Ser Ala Ala Ser Ala Gly Ser Ala Val

325 330 335Gly Ala Leu Lys Ser Ser Asn Asn Ser Gly Arg Ile Ser Leu Leu Leu

340 345 350Asp Asp Val Asp Asn Glu Met Ala Ala Ile Ala Met Gln Gly Phe Arg

355 360 365Ser Met Ile Glu Gln Phe Asn Val Asn Asn Pro Ala Thr Ala Lys Glu

370 375 380Leu Gln Ala Met Glu Ala Gln Leu Thr Ala Met Ser Asp Gln Leu Val385 390 395 400Gly Ala Asp Gly Glu Leu Pro Ala Glu Ile Gln Ala Ile Lys Asp Ala

405 410 415Leu Ala Gln Ala Leu Lys Gln Pro Ser Thr Asp Gly Leu Ala Thr Ala

420 425 430Met Gly Gln Val Ala Phe Ala Ala Ala Lys Val Gly Gly Gly Ser Ala

435 440 445Gly Thr Ala Gly Thr Val Gln Met Asn Val Lys Gln Leu Tyr Lys Thr

450 455 460Ala Phe Ser Ser Thr Ser Ser Ser Ser Tyr Ala Ala Ala Leu Ser Asp465 470 475 480Gly Tyr Ser Ala Tyr Lys Thr Leu Asn Ser Leu Tyr Ser Glu Ser Arg

485 490 495Ser Gly Val Gln Ser Ala Ile Ser Gln Thr Ala Asn Pro Ala Leu Ser

500 505 510Arg Ser Val Ser Arg Ser Gly Ile Glu Ser Gln Gly Arg Ser Ala Asp

515 520 525Ala Ser Gln Arg Ala Ala Glu Thr Ile Val Arg Asp Ser Gln Thr Leu

530 535 540Gly Asp Val Tyr Ser Arg Leu Gln Val Leu Asp Ser Leu Met Ser Thr545 550 555 560Ile Val Ser Asn Pro Gln Val Asn Gln Glu Glu Ile Met Gln Lys Leu

565 570 575Thr Ala Ser Ile Ser Lys Ala Pro Gln Phe Gly Tyr Pro Ala Val Gln

580 585 590Asn Ser Ala Asp Ser Leu Gln Lys Phe Ala Ala Gln Leu Glu Arg Glu

595 600 605Phe Val Asp Gly Glu Arg Ser Leu Ala Glu Ser Arg Glu Asn Ala Phe

610 615 620Arg Lys Gln Pro Ala Phe Ile Gln Gln Val Leu Val Asn Ile Ala Ser625 630 635 640Leu Phe Ser Gly Tyr Leu Ser

645<210>437<211>231<212>PRT<213>沙眼衣原体血清变型D<400>437Met Met Glu Val Phe Met Asn Phe Leu Asp Gln Leu Asp Leu Ile Ile

5 10 15Gln Asn Lys His Met Leu Glu His Thr Phe Tyr Val Lys Trp Ser Lys

20 25 30Gly Glu Leu Thr Lys Glu Gln Leu Gln Ala Tyr Ala Lys Asp Tyr Tyr

35 40 45Leu His Ile Lys Ala Phe Pro Lys Tyr Leu Ser Ala Ile His Ser Arg

50 55 60Cys Asp Asp Leu Glu Ala Arg Lys Leu Leu Leu Asp Asn Leu Met Asp65 70 75 80Glu Glu Asn Gly Tyr Pro Asn His Ile Asp Leu Trp Lys Gln Phe Val

85 90 95Phe Ala Leu Gly Val Thr Pro Glu Glu Leu Glu Ala His Glu Pro Ser

100 105 110Glu Ala Ala Lys Ala Lys Val Ala Thr Phe Met Arg Trp Cys Thr Gly

115 120 125Asp Ser Leu Ala Ala Gly Val Ala Ala Leu Tyr Ser Tyr Glu Ser Gln

130 135 140Ile Pro Arg Ile Ala Arg Glu Lys Ile Arg Gly Leu Thr Glu Tyr Phe145 150 155 160Gly Phe Ser Asn Pro Glu Asp Tyr Ala Tyr Phe Thr Glu His Glu Glu

165 170 175Ala Asp Val Arg His Ala Arg Glu Glu Lys Ala Leu Ile Glu Met Leu

180 185 190Leu Lys Asp Asp Ala Asp Lys Val Leu Glu Ala Ser Gln Glu Val Thr

195 200 205Gln Ser Leu Tyr Gly Phe Leu Asp Ser Phe Leu Asp Pro Gly Thr Cys

210 215 220Cys Ser Cys His Gln Ser Tyr225 230<210>438<211>533<212>PRT<213>沙眼衣原体血清变型D<400>438Met Ser Asn Ser Phe Arg Asp Gln Glu Gln Gly Leu Gln Ala Val Phe

5 10 15Arg Ala Ala Arg Val Ile Ser His Met Phe Ser Gln Thr Ile Gly Pro

20 25 30Tyr Gly Phe Ser Thr Ile Val His Asn Val Gln Asp Thr Arg Thr Thr

35 40 45Gln Asp Ser Gln Ser Met Leu Lys Asp Ile Leu Phe Pro Asp Val Phe

50 55 60Glu Asn Ile Gly Met Lys Leu Ile Arg Asp Thr Ala Leu Arg Thr Arg65 70 75 80Met Arg Phe Gly Asp Gly Ala Lys Thr Thr Ala Leu Leu Ile Glu Ala

85 90 95Leu Leu Ala Glu Gly Met Thr Gly Ile Gln Lys Gly Leu Asp Pro His

100 105 110Glu Ile His Arg Gly Met Leu Leu Ala Glu Lys Lys Ile Gln Glu Val

115 120 125Phe Tyr Arg Glu Thr Phe Pro Leu Ser Asp Leu Glu His Thr Val Tyr

130 135 140Val Ser Ser Ile Ala Arg Arg Cys Asn Ser Glu Ile Ala Ser Val Leu145 150 155 160Ser Ser Ala Val Gly Tyr Gly Gly Lys Asn Gly Tyr Tyr Ile Val Glu

165 170 175Glu His Glu Glu His Glu Thr Tyr Trp His Ala Glu Glu His Ala Val

180 185 190Trp Asp Phe Gly Tyr Ala Ser Pro Tyr Phe Ile Thr His Ala Glu Thr

195 200 205Gly Thr Val Glu Tyr Ser Gln Val Tyr Ile Leu Val Ser Glu Gln Pro

210 215 220Leu His Tyr Ser Asn Pro Ser Phe Leu Thr Phe Leu Gln Ser Val Val225 230 235 240Gln Ala Gly Lys Thr Pro Leu Val Ile Leu Ala Glu Ala Phe Asp Lys

245 250 255Glu Leu Leu Ala Met Leu Glu Met Asn Gln Ile Glu Arg Val Phe Pro

260 265 270Val Cys Ala Val Lys Val Ser Gly Lys His Ala Arg Glu Ser Leu Glu

275 280 285Asp Ile Ala Val Leu Thr Gly Ala Thr Leu Leu Ser Glu Met Asp Phe

290 295 300Glu Asp Ser Glu Glu Glu Arg Ile Thr Asn Arg Leu Gly Phe Val Ala305 310 315 320Gly Ile Cys Val Ser Ser Thr Ser Leu Cys Val Pro Arg Glu Thr Asp

325 330 335Asn Lys Gln Arg Met Ala Glu His Cys Ala Phe Leu Gln Asp Lys Leu

340 345 350Ser Phe Ser Gln Glu Glu Glu Ala Ser Ala Arg Leu Arg Arg Arg Leu

355 360 365Ala Arg Leu Ser Ser Gly Glu Val Cys Ile His Ile Ala Ala Asp Cys

370 375 380Ile Pro Gln Glu Glu Ile Gly Tyr Ile Thr Ser Ser Ile Arg Ala Met385 390 395 400Thr Glu Ser Leu Arg Ser Gly Cys Leu Pro Gly Gly Gly Cys Ala Phe

405 410 415Ile Arg Ala Ala Arg Glu Ile Ser Val Pro Leu Ala Leu Ser Pro Ser

420 425 430Glu Arg Phe Gly Phe Leu Ala Val Leu Ser Ala Ala Glu Lys Pro Phe

435 440 445Arg Ala Ile Val Thr Arg Ser Arg Arg Val Glu Glu Glu Val Phe Ser

450 455 460Glu Val Phe Ser Gln Ala Asp Trp Arg Val Gly Phe Asn Gly Val Ser465 470 475 480Gly Phe Val Glu Asp Ile Val Ser Gln Gly Ile Cys Asp Gly Ala Ser

485 490 495Cys Ile Gln Tyr Ala Leu Ser His Ala Val Gly Thr Thr Gly Leu Leu

500 505 510Leu Thr Ser Ala Leu Phe Ile Ala Ser Gln Glu Pro Met Leu Arg Glu

515 520 525Glu Asn Ser Glu Glu

530<210>439<211>465<212>PRT<213>沙眼衣原体血清变型D<400>439Met Asn Glu Ala Phe Asp Cys Val Val Ile Gly Ala Gly Pro Gly Gly

5 10 15Tyr Val Ala Ala Ile Thr Ala Ala Gln Ala Gly Leu Lys Thr Ala Leu

20 25 30Ile Glu Lys Arg Glu Ala Gly Gly Thr Cys Leu Asn Arg Gly Cys Ile

35 40 45Pro Ser Lys Ala Leu Leu Ala Gly Ala Glu Val Val Thr Gln Ile Arg

50 55 60His Ala Asp Gln Phe Gly Ile His Val Glu Gly Phe Ser Ile Asn Tyr65 70 75 80Pro Ala Met Val Gln Arg Lys Asp Ser Val Val Arg Ser Ile Arg Asp

85 90 95Gly Leu Asn Gly Leu Ile Arg Ser Asn Lys Ile Thr Val Phe Ser Gly

100 105 110Arg Gly Ser Leu Ile Ser Ser Thr Glu Val Lys Ile Leu Gly Glu Asn

115 120 125Pro Ser Val Ile Lys Ala His Ser Ile Ile Leu Ala Thr Gly Ser Glu

130 135 140Pro Arg Ala Phe Pro Gly Ile Pro Phe Ser Ala Glu Ser Pro Arg Ile145 150 155 160Leu Cys Ser Thr Gly Val Leu Asn Leu Lys Glu Ile Pro Gln Lys Met

165 170 175Ala Ile Ile Gly Gly Gly Val Ile Gly Cys Glu Phe Ala Ser Leu Phe

180 185 190His Thr Leu Gly Ser Glu Val Ser Val Ile Glu Ala Ser Ser Gln Ile

195 200 205Leu Ala Leu Asn Asn Pro Asp Ile Ser Lys Thr Met Phe Asp Lys Phe

210 215 220Thr Arg Gln Gly Leu Arg Phe Val Leu Glu Ala Ser Val Ser Asn Ile225 230 235 240Glu Asp Ile Gly Asp Arg Val Arg Leu Thr Ile Asn Gly Asn Val Glu

245 250 255Glu Tyr Asp Tyr Val Leu Val Ser Ile Gly Arg Arg Leu Asn Thr Glu

260 265 270Asn Ile Gly Leu Asp Lys Ala Gly Val Ile Cys Asp Glu Arg Gly Val

275 280 285Ile Pro Thr Asp Ala Thr Met Arg Thr Asn Val Pro Asn Ile Tyr Ala

290 295 300Ile Gly Asp Ile Thr Gly Lys Trp Gln Leu Ala His Val Ala Ser His305 310 315 320Gln Gly Ile Ile Ala Ala Arg Asn Ile Ala Gly His Lys Glu Glu Ile

325 330 335Asp Tyr Ser Ala Val Pro Ser Val Ile Phe Thr Phe Pro Glu Val Ala

340 345 350Ser Val Gly Leu Ser Pro Thr Ala Ala Gln Gln Gln Lys Ile Pro Val

355 360 365Lys Val Thr Lys Phe Pro Phe Arg Ala Ile Gly Lys Ala Val Ala Met

370 375 380Gly Glu Ala Asp Gly Phe Ala Ala Ile Ile Ser His Glu Thr Thr Gln385 390 395 400Gln Ile Leu Gly Ala Tyr Val Ile Gly Pro His Ala Ser Ser Leu Ile

405 410 415Ser Glu Ile Thr Leu Ala Val Arg Asn Glu Leu Thr Leu Pro Cys Ile

420 425 430Tyr Glu Thr Ile His Ala His Pro Thr Leu Ala Glu Val Trp Ala Glu

435 440 445Ser Ala Leu Leu Ala Val Asp Thr Pro Leu His Met Pro Pro Ala Lys

450 455 460Lys465<210>440<211>122<212>PRT<213>沙眼衣原体血清变型D<400>440Met Pro Arg Ile Ile Gly Ile Asp Ile Pro Ala Lys Lys Lys Leu Lys

5 10 15Ile Ser Leu Thr Tyr Ile Tyr Gly Ile Gly Pro Ala Leu Ser Lys Glu

20 25 30Ile Ile Ala Arg Leu Gln Leu Asn Pro Glu Ala Arg Ala Ala Glu Leu

35 40 45Thr Glu Glu Glu Val Gly Arg Leu Asn Ala Leu Leu Gln Ser Asp Tyr

85 90 95Pro Val Arg Gly Gln Arg Thr Lys Thr Asn Ser Arg Thr Arg Lys Gly

100 105 110Lys Arg Lys Thr Val Ala Gly Lys Lys Lys

115 120<210>441<211>553<212>PRT<213>沙眼衣原体血清变型D<400>441Met Arg Ile Gly Asp Pro Met Asn Lys Leu Ile Arg Arg Ala Val Thr

5 10 15Ile Phe Ala Val Thr Ser Val Ala Ser Leu Phe Ala Ser Gly Val Leu

20 25 30Glu Thr Ser Met Ala Glu Ser Leu Ser Thr Asn Val Ile Ser Leu Ala

35 40 45Asp Thr Lys Ala Lys Asp Asn Thr Ser His Lys Ser Lys Lys Ala Arg

50 55 60Lys Asn His Ser Lys Glu Thr Pro Val Asp Arg Lys Glu Val Ala Pro65 70 75 80Val His Glu Ser Lys Ala Thr Gly Pro Lys Gln Asp Ser Cys Phe Gly

85 90 95Arg Met Tyr Thr Val Lys Val Asn Asp Asp Arg Asn Val Glu Ile Thr

100 105 110Gln Ala Val Pro Glu Tyr Ala Thr Val Gly Ser Pro Tyr Pro Ile Glu

115 120 125Ile Thr Ala Thr Gly Lys Arg Asp Cys Val Asp Val Ile Ile Thr Gln

130 135 140Gln Leu Pro Cys Glu Ala Glu Phe Val Arg Ser Asp Pro Ala Thr Thr145 150 155 160Pro Thr Ala Asp Gly Lys Leu Val Trp Lys Ile Asp Arg Leu Gly Gln

165 170 175Gly Glu Lys Ser Lys Ile Thr Val Trp Val Lys Pro Leu Lys Glu Gly

180 185 190Cys Cys Phe Thr Ala Ala Thr Val Cys Ala Cys Pro Glu Ile Arg Ser

195 200 205Val Thr Lys Cys Gly Gln Pro Ala Ile Cys Val Lys Gln Glu Gly Pro

210 215 220Glu Asn Ala Cys Leu Arg Cys Pro Val Val Tyr Lys Ile Asn Ile Val225 230 235 240Asn Gln Gly Thr Ala Thr Ala Arg Asn Val Val Val Glu Asn Pro Val

245 250 255Pro Asp Gly Tyr Ala His Ser Ser Gly Gln Arg Val Leu Thr Phe Thr

260 265 270Leu Gly Asp Met Gln Pro Gly Glu His Arg Thr Ile Thr Val Glu Phe

275 280 285Cys Pro Leu Lys Arg Gly Arg Ala Thr Asn Ile Ala Thr Val Ser Tyr

290 295 300Cys Gly Gly His Lys Asn Thr Ala Ser Val Thr Thr Val Ile Asn Glu305 310 315 320Pro Cys Val Gln Val Ser Ile Ala Gly Ala Asp Trp Ser Tyr Val Cys

325 330 335Lys Pro Val Glu Tyr Val Ile Ser Val Ser Asn Pro Gly Asp Leu Val

340 345 350Leu Arg Asp Val Val Val Glu Asp Thr Leu Ser Pro Gly Val Thr Val

355 360 365Leu Glu Ala Ala Gly Ala Gln Ile Ser Cys Asn Lys Val Val Trp Thr

370 375 380Val Lys Glu Leu Asn Pro Gly Glu Ser Leu Gln Tyr Lys Val Leu Val385 390 395 400Arg Ala Gln Thr Pro Gly Gln Phe Thr Asn Asn Val Val Val Lys Ser

405 410 415Cys Ser Asp Cys Gly Thr Cys Thr Ser Cys Ala Glu Ala Thr Thr Tyr

420 425 430Trp Lys Gly Val Ala Ala Thr His Met Cys Val Val Asp Thr Cys Asp

435 440 445Pro Val Cys Val Gly Glu Asn Thr Val Tyr Arg Ile Cys Val Thr Asn

450 455 460Arg Gly Ser Ala Glu Asp Thr Asn Val Ser Leu Met Leu Lys Phe Ser465 470 475 480Lys Glu Leu Gln Pro Val Ser Phe Ser Gly Pro Thr Lys Gly Thr Ile

485 490 495Thr Gly Asn Thr Val Val Phe Asp Ser Leu Pro Arg Leu Gly Ser Lys

500 505 510Glu Thr Val Glu Phe Ser Val Thr Leu Lys Ala Val Ser Ala Gly Asp

515 520 525Ala Arg Gly Glu Ala Ile Leu Ser Ser Asp Thr Leu Thr Val Pro Val

530 535 540Ser Asp Thr Glu Asn Thr His Ile Tyr545 550<210>442<211>192<212>PRT<213>沙眼衣原体血清变型D<400>442Met Pro Glu Gly Glu Met Met His Lys Leu Gln Asp Val Ile Asp Arg

5 10 15Lys Leu Leu Asp Ser Arg Arg Ile Phe Phe Ser Glu Pro Val Thr Glu

20 25 30Lys Ser Ala Thr Glu Ala Ile Lys Lys Leu Trp Tyr Leu Glu Leu Thr

35 40 45Asn Pro Gly Gln Pro Ile Val Phe Val Ile Asn Ser Pro Gly Gly Ser

50 55 60Val Asp Ala Gly Phe Ala Val Trp Asp Gln Ile Lys Met Ile Ser Ser65 70 75 80Pro Leu Thr Thr Val Val Thr Gly Leu Ala Ala Ser Met Gly Ser Val

85 90 95Leu Ser Leu Cys Ala Val Pro Gly Arg Arg Phe Ala Thr Pro His Ala

100 105 110Arg Ile Met Ile His Gln Pro Ser Ile Gly Gly Thr Ile Thr Gly Gln

115 120 125Ala Thr Asp Leu Asp Ile His Ala Arg Glu Ile Leu Lys Thr Lys Ala

130 135 140Arg Ile Ile Asp Val Tyr Val Glu Ala Thr Gly Gln Ser Arg Glu Val145 150 155 160Ile Glu Lys Ala Ile Asp Arg Asp Met Trp Met Ser Ala Asn Glu Ala

165 170 175Met Glu Phe Gly Leu Leu Asp Gly Ile Leu Phe Ser Phe Asn Asp Leu

180 185 190<210>443<211>275<212>PRT<213>沙眼衣原体血清变型D<400>443Met Gly Phe Ser Ser Leu Leu Thr Thr Cys Arg Tyr Leu Leu Tyr Ser

5 10 15Gly Ala Gly Asn Ser Phe Ile Leu Gly Glu Ser Met Pro Ser Leu Glu

20 25 30Asp Val Leu Phe Leu Cys Gln Glu Glu Met Val Asp Gly Phe Leu Cys

35 40 45Val Glu Ser Ser Glu Ile Ala Asp Ala Lys Leu Thr Val Phe Asn Ser

50 55 60Asp Gly Ser Ile Ala Ser Met Cys Gly Asn Gly Leu Arg Cys Ala Met65 70 75 80Ala His Val Ala Gln Cys Phe Gly Leu Glu Asp Val Ser Ile Glu Thr

85 90 95Glu Arg Gly Val Tyr Gln Gly Lys Phe Phe Ser Met Asn Arg Val Leu

100 105 110Val Asp Met Thr Leu Pro Asp Trp Lys Lys Ala Glu Arg Lys Leu Thr

115 120 125His Val Leu Pro Gly Met Pro Glu Gln Val Phe Phe Ile Asp Thr Gly

130 135 140Val Pro His Val Val Val Phe Val Ser Asp Leu Ser Lys Val Pro Val145 150 155 160Gln Glu Trp Gly Ser Phe Leu Arg Tyr His Glu Asp Phe Ala Pro Glu

165 170 175Gly Val Asn Val Asp Phe Val Gln Arg Lys Lys Asp Asp Leu Leu Leu

180 185 190Val Tyr Thr Tyr Glu Arg Gly Cys Glu Arg Glu Thr Leu Ser Cys Gly

195 200 205Thr Gly Met Leu Ala Ser Ala Leu Val Ala Ala Asp Ile Phe Ser Leu

210 215 220Gly Gln Asp Phe Ser Ile Ala Val Cys Ser Arg Ser Arg Asn Leu Ile225 230 235 240Lys Ile Phe Ser Glu Lys Gly Lys Val Phe Leu Glu Gly Pro Val Ser

245 250 255Leu Leu Asn Arg Ser Glu Asn Phe Gly Trp Leu Glu Pro Lys Ser Arg

260 265 270Arg Phe Gly

275<210>444<211>1770<212>PRT<213>沙眼衣原体血清变型D<400>444Met Lys Phe Met Ser Ala Thr Ala Val Phe Ala Ala Ala Leu Ser Ser

5 10 15Val Thr Glu Ala Ser Ser Ile Gln Asp Gln Ile Lys Asn Thr Asp Cys

20 25 30Asn Val Ser Lys Leu Gly Tyr Ser Thr Ser Gln Ala Phe Thr Asp Met

35 40 45Met Leu Ala Asp Asn Thr Glu Tyr Arg Ala Ala Asp Ser Val Ser Phe

50 55 60Tyr Asp Phe Ser Thr Ser Ser Arg Leu Pro Arg Lys His Leu Ser Ser65 70 75 80Ser Ser Glu Ala Ser Pro Thr Thr Glu Gly Val Ser Ser Ser Ser Ser

85 90 95Gly Glu Thr Asp Glu Lys Thr Glu Glu Glu Leu Asp Asn Gly Gly Ile

100 105 110Ile Tyr Ala Arg Glu Lys Leu Thr Ile Ser Glu Ser Gln Asp Ser Leu

115 120 125Ser Asn Gln Ser Ile Glu Leu His Asp Asn Ser Ile Phe Phe Gly Glu

130 135 140Gly Glu Val Ile Phe Asp His Arg Val Ala Leu Lys Asn Gly Gly Ala145 150 155 160Ile Tyr Gly Glu Lys Glu Val Val Phe Glu Asn Ile Lys Ser Leu Leu

165 170 175Val Glu Val Asn Ile Ala Val Glu Lys Gly Gly Ser Val Tyr Ala Lys

180 185 190Glu Arg Val Ser Leu Glu Asn Val Thr Glu Ala Thr Phe Ser Ser Asn

195 200 205Gly Gly Glu Gln Gly Gly Gly Gly Ile Tyr Ser Glu Gln Asp Met Leu

210 215 220Ile Ser Asp Cys Asn Asn Val His Phe Gln Gly Asn Ala Ala Gly Ala225 230 235 240Thr Ala Val Lys Gln Cys Leu Asp Glu Glu Met Ile Val Leu Leu Ala

245 250 255Glu Cys Val Asp Ser Leu Ser Glu Asp Thr Leu Asp Ser Thr Pro Glu

260 265 270Thr Glu Gln Thr Glu Ser Asn Gly Asn Gln Asp Gly Ser Ser Glu Thr

275 280 285Glu Asp Thr Gln Val Ser Glu Ser Pro Glu Ser Thr Pro Ser Pro Asp

290 295 300Asp Val Leu Gly Lys Gly Gly Gly Ile Tyr Thr Glu Lys Ser Leu Thr305 310 315 320Ile Thr Gly Ile Thr Gly Thr Ile Asp Phe Val Ser Asn Ile Ala Thr

325 330 335Asp Ser Gly Ala Gly Val Phe Thr Lys Glu Asn Leu Ser Cys Thr Asn

340 345 350Thr Asn Ser Leu Gln Phe Leu Lys Asn Ser Ala Gly Gln His Gly Gly

355 360 365Gly Ala Tyr Val Thr Gln Thr Met Ser Val Thr Asn Thr Thr Ser Glu

370 375 380Ser Ile Thr Thr Pro Pro Leu Ile Gly Glu Val Ile Phe Ser Glu Asn385 390 395 400Thr Ala Lys Gly His Gly Gly Gly Ile Cys Thr Asn Lys Leu Ser Leu

405 410 415Ser Asn Leu Lys Thr Val Thr Leu Thr Lys Asn Ser Ala Lys Glu Ser

420 425 430Gly Gly Ala Ile Phe Thr Asp Leu Ala Ser Ile Pro Ile Thr Asp Thr

435 440 445Pro Glu Ser Ser Thr Pro Ser Ser Ser Ser Pro Ala Ser Thr Pro Glu

450 455 460Val Val Ala Ser Ala Lys Ile Asn Arg Phe Phe Ala Ser Thr Ala Lys465 470 475 480Pro Ala Ala Pro Ser Leu Thr Glu Ala Glu Ser Asp Gln Thr Asp Gln

485 490 495Thr Glu Thr Ser Asp Thr Asn Ser Asp Ile Asp Val Ser Ile Glu Asn

500 505 510Ile Leu Asn Val Ala Ile Asn Gln Asn Thr Ser Ala Lys Lys Gly Gly

515 520 525Ala Ile Tyr Gly Lys Lys Ala Lys Leu Ser Arg Ile Asn Asn Leu Glu

530 535 540Leu Ser Gly Asn Ser Ser Gln Asp Val Gly Gly Gly Leu Cys Leu Thr545 550 555 560Glu Ser Val Glu Phe Asp Ala Ile Gly Ser Leu Leu Ser His Tyr Asn

565 570 575Ser Ala Ala Lys Glu Gly Gly Ala Ile His Ser Lys Thr Val Thr Leu

580 585 590Ser Asn Leu Lys Ser Thr Phe Thr Phe Ala Asp Asn Thr Val Lys Ala

595 600 605Ile Val Glu Ser Thr Pro Glu Ala Pro Glu Glu Ile Pro Pro Val Glu

610 615 620Gly Glu Glu Ser Thr Ala Thr Glu Asp Pro Asn Ser Asn Thr Glu Gly625 630 635 640Ser Ser Ala Asn Thr Asn Leu Glu Gly Ser Gln Gly Asp Thr Ala Asp

645 650 655Thr Gly Thr Gly Asp Val Asn Asn Glu Ser Gln Asp Thr Ser Asp Thr

660 665 670Gly Asn Ala Glu Ser Glu Glu Gln Leu Gln Asp Ser Thr Gln Ser Asn

675 680 685Glu Glu Asn Thr Leu Pro Asn Ser Asn Ile Asp Gln Ser Asn Glu Asn

690 695 700Thr Asp Glu Ser Ser Asp Ser His Thr Glu Glu Ile Thr Asp Glu Ser705 710 715 720Val Ser Ser Ser Ser Glu Ser Gly Ser Ser Thr Pro Gln Asp Gly Gly

725 730 735Ala Ala Ser Ser Gly Ala Pro Ser Gly Asp Gln Ser Ile Ser Ala Asn

740 745 750Ala Cys Leu Ala Lys Ser Tyr Ala Ala Ser Thr Asp Ser Ser Pro Val

755 760 765Ser Asn Ser Ser Gly Ser Glu Glu Pro Val Thr Ser Ser Ser Asp Ser

770 775 780Asp Val Thr Ala Ser Ser Asp Asn Pro Asp Ser Ser Ser Ser Gly Asp785 790 795 800Ser Ala Gly Asp Ser Glu Glu Pro Thr Glu Pro Glu Ala Gly Ser Thr

805 810 815Thr Glu Thr Leu Thr Leu Ile Gly Gly Gly Ala Ile Tyr Gly Glu Thr

820 825 830Val Lys Ile Glu Asn Phe Ser Gly Gln Gly Ile Phe Ser Gly Asn Lys

835 840 845Ala Ile Asp Asn Thr Thr Glu Gly Ser Ser Ser Lys Ser Asp Val Leu

850 855 860Gly Gly Ala Val Tyr Ala Lys Thr Leu Phe Asn Leu Asp Ser Gly Ser865 870 875 880Ser Arg Arg Thr Val Thr Phe Ser Gly Asn Thr Val Ser Ser Gln Ser

885 890 895Thr Thr Gly Gln Val Ala Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr

900 905 910Ile Ala Thr Pro Val Val Phe Ser Lys Asn Ser Ala Thr Asn Asn Ala

915 920 925Asn Asn Thr Thr Asp Thr Gln Arg Lys Asp Thr Phe Gly Gly Ala Ile

930 935 940Gly Ala Thr Ser Ala Val Ser Leu Ser Gly Gly Ala His Phe Leu Glu945 950 955 960Asn Val Ala Asp Leu Gly Ser Ala Ile Gly Leu Val Pro Gly Thr Gln

965 970 975Asn Thr Glu Thr Val Lys Leu Glu Ser Gly Ser Tyr Tyr Phe Glu Lys

980 985 990Asn Lys Ala Leu Lys Arg Ala Thr Ile Tyr Ala Pro Val Val Ser Ile

995 1000 1005Lys Ala Tyr Thr Ala Thr Phe Asn Gln Asn Arg Ser Leu Glu Glu Gly

1010 1015 1020Ser Ala Ile Tyr Phe Thr Lys Glu Ala Ser Ile Glu Ser Leu Gly Ser1025 1030 1035 1040Val Leu Phe Thr Gly Asn Leu Val Thr Leu Thr Leu Ser Thr Thr Thr

1045 1050 1055Glu Gly Thr Pro Ala Thr Thr Ser Gly Asp Val Thr Lys Tyr Gly Ala

1060 1065 1070Ala Ile Phe Gly Gln Ile Ala Ser Ser Asn Gly Ser Gln Thr Asp Asn

1075 1080 1085Leu Pro Leu Lys Leu Ile Ala Ser Gly Gly Asn Ile Cys Phe Arg Asn

1090 1095 1100Asn Glu Tyr Arg Pro Thr Ser Ser Asp Thr Gly Thr Ser Thr Phe Cys1105 1110 1115 1120Ser Ile Ala Gly Asp Val Lys Leu Thr Met Gln Ala Ala Lys Gly Lys

1125 1130 1135Thr Ile Ser Phe Phe Asp Ala Ile Arg Thr Ser Thr Lys Lys Thr Gly

1140 1145 1150Thr Gln Ala Thr Ala Tyr Asp Thr Leu Asp Ile Asn Lys Ser Glu Asp

1155 1160 1165Ser Glu Thr Val Asn Ser Ala Phe Thr Gly Thr Ile Leu Phe Ser Ser

1170 1175 1180Glu Leu His Glu Asn Lys Ser Tyr Ile Pro Gln Asn Val Val Leu His1185 1190 1195 1200Ser Gly Ser Leu Val Leu Lys Pro Asn Thr Glu Leu His Val Ile Ser

1205 1210 1215Phe Glu Gln Lys Glu Gly Ser Ser Leu Val Met Thr Pro Gly Ser Val

1220 1225 1230Leu Ser Asn Gln Thr Val Ala Asp Gly Ala Leu Val Ile Asn Asn Met

1235 1240 1245Thr Ile Asp Leu Ser Ser Val Glu Lys Asn Gly Ile Ala Glu Gly Asn

1250 1255 1260Ile Phe Thr Pro Pro Glu Leu Arg Ile Ile Asp Thr Thr Thr Gly Gly1265 1270 1275 1280Ser Gly Gly Thr Pro Ser Thr Asp Ser Glu Ser Asn Gln Asn Ser Asp

1285 1290 1295Asp Thr Glu Glu Gln Asn Asn Asn Asp Ala Ser Asn Gln Gly Glu Ser

1300 1305 1310Ala Asn Gly Ser Ser Ser Pro Ala Val Ala Ala Ala His Thr Ser Arg

1315 1320 1325Thr Arg Asn Phe Ala Ala Ala Ala Thr Ala Thr Pro Thr Thr Thr Pro

1330 1335 1340Thr Ala Thr Thr Thr Thr Ser Asn Gln Val Ile Leu Gly Gly Glu Ile1345 1350 1355 1360Lys Leu Ile Asp Pro Asn Gly Thr Phe Phe Gln Asn Pro Ala Leu Arg

1365 1370 1375Ser Asp Gln Gln Ile Ser Leu Leu Val Leu Pro Thr Asp Ser Ser Lys

1380 1385 1390Met Gln Ala Gln Lys Ile Val Leu Thr Gly Asp Ile Ala Pro Gln Lys

1395 1400 1405Gly Tyr Thr Gly Thr Leu Thr Leu Asp Pro Asp Gln Leu Gln Asn Gly

1410 1415 1420Thr Ile Ser Val Leu Trp Lys Phe Asp Ser Tyr Arg Gln Trp Ala Tyr1425 1430 1435 1440Val Pro Arg Asp Asn His Phe Tyr Ala Asn Ser Ile Leu Gly Ser Gln

1445 1450 1455Met Leu Met Val Thr Val Lys Gln Gly Leu Leu Asn Asp Lys Met Asn

1460 1465 1470Leu Ala Arg Phe Glu Glu Val Ser Tyr Asn Asn Leu Trp Ile Ser Gly

1475 1480 1485Leu Gly Thr Met Leu Ser Gln Val Gly Thr Pro Thr Ser Glu Glu Phe

1490 1495 1500Thr Tyr Tyr Ser Arg Gly Ala Ser Val Ala Leu Asp Ala Lys Pro Ala1505 1510 1515 1520His Asp Val Ile Val Gly Ala Ala Phe Ser Lys Met Ile Gly Lys Thr

1525 1530 1535Lys Ser Leu Lys Arg Glu Asn Asn Tyr Thr His Lys Gly Ser Glu Tyr

1540 1545 1550Ser Tyr Gln Ala Ser Val Tyr Gly Gly Lys Pro Phe His Phe Val Ile

1555 1560 1565Asn Lys Lys Thr G1u Lys Ser Leu Pro Leu Leu Leu Gln Gly Val Ile

1570 1575 1580Ser Tyr Gly Tyr Ile Lys His Asp Thr Val Thr His Tyr Pro Thr Ile1585 1590 1595 1600Arg Glu Arg Asn Lys Gly Glu Trp Glu Asp Leu Gly Trp Leu Thr Ala

1605 1610 1615Leu Arg Val Ser Ser Val Leu Arg Thr Pro Ala Gln Gly Asp Thr Lys

1620 1625 1630Arg Ile Thr Val Tyr Gly Glu Leu Glu Tyr Ser Ser Ile Arg Gln Lys

1635 1640 1645Gln Phe Thr Glu Thr Glu Tyr Asp Pro Arg Tyr Phe Asp Asn Cys Thr

1650 1655 1660Tyr Arg Asn Leu Ala Ile Pro Met Gly Leu Ala Phe Glu Gly Glu Leu1665 1670 1675 1680Ser Gly Asn Asp Ile Leu Met Tyr Asn Arg Phe Ser Val Ala Tyr Met

1685 1690 1695Leu Ser Ile Tyr Arg Asn Ser Pro Thr Cys Lys Tyr Gln Val Leu Ser

1700 1705 1710Ser Gly Glu Gly Gly Glu Ile Ile Cys Gly Val Pro Thr Arg Asn Ser

1715 1720 1725Ala Arg Gly Glu Tyr Ser Thr Gln Leu Tyr Leu Gly Pro Leu Trp Thr

1730 1735 1740Leu Tyr Gly Ser Tyr Thr Ile Glu Ala Asp Ala His Thr Leu Ala His1745 1750 1755 1760Met Met Asn Cys Gly Ala Arg Met Thr Phe

1765 1770<210>445<211>1751<212>PRT<213>沙眼衣原体血清变型D<400>445Met Lys Trp Leu Ser Ala Thr Ala Val Phe Ala Ala Val Leu Pro Ser

5 10 15Val Ser Gly Phe Cys Phe Pro Glu Pro Lys Glu Leu Asn Phe Ser Arg

20 25 30Val Gly Thr Ser Ser Ser Thr Thr Phe Thr Glu Thr Val Gly Glu Ala

35 40 45Gly Ala Glu Tyr Ile Val Ser Gly Asn Ala Ser Phe Thr Lys Phe Thr

50 55 60Asn Ile Pro Thr Thr Asp Thr Thr Thr Pro Thr Asn Ser Asn Ser Ser65 70 75 80Ser Ser Asn Gly Glu Thr Ala Ser Val Ser Glu Asp Ser Asp Ser Thr

85 90 95Thr Thr Thr Pro Asp Pro Lys Gly Gly Gly Ala Phe Tyr Asn Ala His

100 105 110Ser Gly Val Leu Ser Phe Met Thr Arg Ser Gly Thr Glu Gly Ser Leu

115 120 125Thr Leu Ser Glu Ile Lys Ile Thr Gly Glu Gly Gly Ala Ile Phe Ser

130 135 140Gln Gly Glu Leu Leu Phe Thr Asp Leu Thr Gly Leu Thr Ile Gln Asn145 150 155 160Asn Leu Ser Gln Leu Ser Gly Gly Ala Ile Phe Gly Glu Ser Thr Ile

165 170 175Ser Leu Ser Gly Ile Thr Lys Ala Thr Phe Ser Ser Asn Ser Ala Glu

180 185 190Val Pro Ala Pro Val Lys Lys Pro Thr Glu Pro Lys Ala Gln Thr Ala

195 200 205Ser Glu Thr Ser Gly Ser Ser Ser Ser Ser Gly Asn Asp Ser Val Ser

245 250 255Thr Ser Thr Pro Ser His Lys Pro Gly Ser Gly Gly Ala Ile Tyr Ala

260 265 270Lys Gly Asp Leu Thr Ile Ala Asp Ser Gln Glu Val Leu Phe Ser Ile

275 280 285Asn Lys Ala Thr Lys Asp Gly Gly Ala Ile Phe Ala Glu Lys Asp Val

325 330 335Ser Lys Gln Ser Leu Phe Asn Ser Asn Tyr Ser Lys Gln Gly Gly Gly

340 345 350Ala Leu Tyr Val Glu Gly Asp Ile Asn Phe Gln Asp Leu Glu Glu Ile

355 360 365Arg Ile Lys Tyr Asn Lys Ala Gly Thr Phe Glu Thr Lys Lys Ile Thr

370 375 380Leu Pro Lys Ala Gln Ala Ser Ala Gly Asn Ala Asp Ala Trp Ala Ser385 390 395 400Ser Ser Pro Gln Ser Gly Ser Gly Ala Thr Thr Val Ser Asn Ser Gly

405 410 415Asp Ser Ser Ser Gly Ser Asp Ser Asp Thr Ser Glu Thr Val Pro Ala

420 425 430Thr Ala Lys Gly Gly Gly Leu Tyr Thr Asp Lys Asn Leu Ser Ile Thr

435 440 445Asn Ile Thr Gly Ile Ile Glu Ile Ala Asn Asn Lys Ala Thr Asp Val

450 455 460Gly Gly Gly Ala Tyr Val Lys Gly Thr Leu Thr Cys Glu Asn Ser His465 470 475 480Arg Leu Gln Phe Leu Lys Asn Ser Ser Asp Lys Gln Gly Gly Gly Ile

485 490 495Tyr Gly Glu Asp Asn Ile Thr Leu Ser Asn Leu Thr Gly Lys Thr Leu

500 505 510Phe Gln Glu Asn Thr Ala Lys Glu Glu Gly Gly Gly Leu Phe Ile Lys

515 520 525Gly Thr Asp Lys Ala Leu Thr Met Thr Gly Leu Asp Ser Phe Cys Leu

530 535 540Ile Asn Asn Thr Ser Glu Lys His Gly Gly Gly Ala Phe Val Thr Lys545 550 555 560Glu Ile Ser Gln Thr Tyr Thr Ser Asp Val Glu Thr Ile Pro Gly Ile

565 570 575Thr Pro Val His Gly Glu Thr Val Ile Thr Gly Asn Lys Ser Thr Gly

580 585 590Gly Asn Gly Gly Gly Val Cys Thr Lys Arg Leu Ala Leu Ser Asn Leu

595 600 605Gln Ser Ile Ser Ile Ser Gly Asn Ser Ala Ala Glu Asn Gly Gly Gly

610 615 620Ala His Thr Cys Pro Asp Ser Phe Pro Thr Ala Asp Thr Ala Glu Gln625 630 635 640Pro Ala Ala Ala Ser Ala Ala Thr Ser Thr Pro Glu Ser Ala Pro Val

645 650 655Val Ser Thr Ala Leu Ser Thr Pro Ser Ser Ser Thr Val Ser Ser Leu

660 665 670Thr Leu Leu Ala Ala Ser Ser Gln Ala Ser Pro Ala Thr Ser Asn Lys

675 680 685Glu Thr Gln Asp Pro Asn Ala Asp Thr Asp Leu Leu Ile Asp Tyr Val

690 695 700Val Asp Thr Thr Ile Ser Lys Asn Thr Ala Lys Lys Gly Gly Gly Ile705 710 715 720Tyr Ala Lys Lys Ala Lys Met Ser Arg Ile Asp Gln Leu Asn Ile Ser

725 730 735Glu Asn Ser Ala Thr Glu Ile Gly Gly Gly Ile Cys Cys Lys Glu Ser

740 745 750Leu Glu Leu Asp Ala Leu Val Ser Leu Ser Val Thr Glu Asn Leu Val

755 760 765Gly Lys Glu Gly Gly Gly Leu His Ala Lys Thr Val Asn Ile Ser Asn

770 775 780Leu Lys Ser Gly Phe Ser Phe Ser Asn Asn Lys Ala Asn Ser Ser Ser785 790 795 800Thr Gly Val Ala Thr Thr Ala Ser Ala Pro Ala Ala Ala Ala Ala Ser

805 810 815Leu Gln Ala Ala Ala Ala Ala Val Pro Ser Ser Pro Ala Thr Pro Thr

820 825 830Tyr Ser Gly Val Val Gly Gly Ala Ile Tyr Gly Glu Lys Val Thr Phe

835 840 845Ser Gln Cys Ser Gly Thr Cys Gln Phe Ser Gly Asn Gln Ala Ile Asp

850 855 860Asn Asn Pro Ser Gln Ser Ser Leu Asn Val Gln Gly Gly Ala Ile Tyr865 870 875 880Ala Lys Thr Ser Leu Ser Ile Gly Ser Ser Asp Ala Gly Thr Ser Tyr

885 890 895Ile Phe Ser Gly Asn Ser Val Ser Thr Gly Lys Ser Gln Thr Thr Gly

900 905 910Gln Ile Ala Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr Leu Asn Cys

915 920 925Pro Ala Thr Phe Ser Asn Asn Thr Ala Ser Met Ala Thr Pro Lys Thr

930 935 940Ser Ser Glu Asp Gly Ser Ser Gly Asn Ser Ile Lys Asp Thr Ile Gly945 950 955 960Gly Ala Ile Ala Gly Thr Ala Ile Thr Leu Ser Gly Val Ser Arg Phe

965 970 975Ser Gly Asn Thr Ala Asp Leu Gly Ala Ala Ile Gly Thr Leu Ala Asn

980 985 990Ala Asn Thr Pro Ser Ala Thr Ser Gly Ser Gln Asn Ser Ile Thr Glu

995 1000 1005Lys Ile Thr Leu Glu Asn Gly Ser Phe Ile Phe Glu Arg Asn Gln Ala

1010 1015 1020Asn Lys Arg Gly Ala Ile Tyr Ser Pro Ser Val Ser Ile Lys Gly Asn1025 1030 1035 1040Asn Ile Thr Phe Asn Gln Asn Thr Ser Thr His Asp Gly Ser Ala Ile

1045 1050 1055Tyr Phe Thr Lys Asp Ala Thr Ile Glu Ser Leu Gly Ser Val Leu Phe

1060 1065 1070Thr Gly Asn Asn Val Thr Ala Thr Gln Ala Ser Ser Ala Thr Ser Gly

1075 1080 1085Gln Asn Thr Asn Thr Ala Asn Tyr Gly Ala Ala Ile Phe Gly Asp Pro

1090 1095 1100Gly Thr Thr Gln Ser Ser Gln Thr Asp Ala Ile Leu Thr Leu Leu Ala1105 1110 1115 1120Ser Ser Gly Asn Ile Thr Phe Ser Asn Asn Ser Leu Gln Asn Asn Gln

1125 1130 1135Gly Asp Thr Pro Ala Ser Lys Phe Cys Ser Ile Ala Gly Tyr Val Lys

1140 1145 1150Leu Ser Leu Gln Ala Ala Lys Gly Lys Thr Ile Ser Phe Phe Asp Cys

1155 1160 1165Val His Thr Ser Thr Lys Lys Ile Gly Ser Thr Gln Asn Val Tyr Glu

1170 1175 1180Thr Leu Asp Ile Asn Lys Glu Glu Asn Ser Asn Pro Tyr Thr Gly Thr1185 1190 1195 1200Ile Val Phe Ser Ser Glu Leu His Glu Asn Lys Ser Tyr Ile Pro Gln

1205 1210 1215Asn Ala Ile Leu His Asn Gly Thr Leu Val Leu Lys Glu Lys Thr Glu

1220 1225 1230Leu His Val Val Ser Phe Glu Gln Lys Glu Gly Ser Lys Leu Ile Met

1235 1240 1245Lys Pro Gly Ala Val Leu Ser Asn Gln Asn Ile Ala Asn Gly Ala Leu

1250 1255 1260Val Ile Asn Gly Leu Thr Ile Asp Leu Ser Ser Met Gly Thr Pro Gln1265 1270 1275 1280Ala Gly Glu Ile Phe Ser Pro Pro Glu Leu Arg Ile Val Ala Thr Thr

1285 1290 1295Ser Ser Ala Ser Gly Gly Ser Gly Val Ser Ser Ser Ile Pro Thr Asn

1300 1305 1310Pro Lys Arg Ile Ser Ala Ala Ala Pro Ser Gly Ser Ala Ala Thr Thr

1315 1320 1325Pro Thr Met Ser Glu Asn Lys Val Phe Leu Thr Gly Asp Leu Thr Leu

1330 1335 1340Ile Asp Pro Asn Gly Asn Phe Tyr Gln Asn Pro Met Leu Gly Ser Asp1345 1350 1355 1360Leu Asp Val Pro Leu Ile Lys Leu Pro Thr Asn Thr Ser Asp Val Gln

1365 1370 1375Val Tyr Asp Leu Thr Leu Ser Gly Asp Leu Phe Pro Gln Lys Gly Tyr

1380 1385 1390Met Gly Thr Trp Thr Leu Asp Ser Asn Pro Gln Thr Gly Lys Leu Gln

1395 1400 1405Ala Arg Trp Thr Phe Asp Thr Tyr Arg Arg Trp Val Tyr Ile Pro Arg

1410 1415 1420Asp Asn His Phe Tyr Ala Asn Ser Ile Leu Gly Ser Gln Asn Ser Met1425 1430 1435 l440Ile Val Val Lys Gln Gly Leu Ile Asn Asn Met Leu Asn Asn Ala Arg

1445 1450 1455Phe Asp Asp Ile Ala Tyr Asn Asn Phe Trp Val Ser Gly Val Gly Thr

1460 1465 1470Phe Leu Ala Gln Gln Gly Thr Pro Leu Ser Glu Glu Phe Ser Tyr Tyr

1475 1480 1485Ser Arg Gly Thr Ser Val Ala Ile Asp Ala Lys Pro Arg Gln Asp Phe

1490 1495 1500Ile Leu Gly Ala Ala Phe Ser Lys Met Val Gly Lys Thr Lys Ala Ile1505 1510 1515 1520Lys Lys Met His Asn Tyr Phe His Lys Gly Ser Glu Tyr Ser Tyr Gln

1525 1530 1535Ala Ser Val Tyr Gly Gly Lys Phe Leu Tyr Phe Leu Leu Asn Lys Gln

1540 1545 1550His Gly Trp Ala Leu Pro Phe Leu Ile Gln Gly Val Val Ser Tyr Gly

1555 1560 1565His Ile Lys His Asp Thr Thr Thr Leu Tyr Pro Ser Ile His Glu Arg

1570 1575 1580Asn Lys Gly Asp Trp Glu Asp Leu Gly Trp Leu Ala Asp Leu Arg Ile1585 1590 1595 1600Ser Met Asp Leu Lys Glu Pro Ser Lys Asp Ser Ser Lys Arg Ile Thr

1605 1610 1615Val Tyr Gly Glu Leu Glu Tyr Ser Ser Ile Arg Gln Lys Gln Phe Thr

1620 1625 1630Glu Ile Asp Tyr Asp Pro Arg His Phe Asp Asp Cys Ala Tyr Arg Asn

1635 1640 1645Leu Ser Leu Pro Val Gly Cys Ala Val Glu Gly Ala Ile Met Asn Cys

1650 1655 1660Asn Ile Leu Met Tyr Asn Lys Leu Ala Leu Ala Tyr Met Pro Ser Ile1665 1670 1675 1680Tyr Arg Asn Asn Pro Val Cys Lys Tyr Arg Val Leu Ser Ser Asn Glu

1685 1690 1695Ala Gly Gln Val Ile Cys Gly Val Pro Thr Arg Thr Ser Ala Arg Ala

1700 1705 1710Glu Tyr Ser Thr Gln Leu Tyr Leu Gly Pro Phe Trp Thr Leu Tyr Gly

1715 1720 1725Asn Tyr Thr Ile Asp Val Gly Met Tyr Thr Leu Ser Gln Met Thr Ser

1730 1735 1740Cys Gly Ala Arg Met Ile Phe1745 1750<210>446<211>660<212>PRT<213>沙眼衣原体血清变型D<400>446Met Ser Glu Lys Arg Lys Ser Asn Lys Ile Ile Gly Ile Asp Leu Gly

5 10 15Thr Thr Asn Ser Cys Val Ser Val Met Glu Gly Gly Gln Pro Lys Val

20 25 30Ile Ala Ser Ser Glu Gly Thr Arg Thr Thr Pro Ser Ile Val Ala Phe

35 40 45Lys Gly Gly Glu Thr Leu Val Gly Ile Pro Ala Lys Arg Gln Ala Val

50 55 60Thr Asn Pro Glu Lys Thr Leu Ala Ser Thr Lys Arg Phe Ile Gly Arg65 70 75 80Lys Phe Ser Glu Val Glu Ser Glu Ile Lys Thr Val Pro Tyr Lys Val

85 90 95Ala Pro Asn Ser Lys Gly Asp Ala Val Phe Asp Val Glu Gln Lys Leu

100 105 110Tyr Thr Pro Glu Glu Ile Gly Ala Gln Ile Leu Met Lys Met Lys Glu

115 120 125Thr Ala Glu Ala Tyr Leu Gly Glu Thr Val Thr Glu Ala Val Ile Thr

130 135 140Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Ala Ser Thr Lys Asp Ala145 150 155 160Gly Arg Ile Ala Gly Leu Asp Val Lys Arg Ile Ile Pro Glu Pro Thr

165 170 175Ala Ala Ala Leu Ala Tyr Gly Ile Asp Lys Glu Gly Asp Lys Lys Ile

180 185 190Ala Val Phe Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu

195 200 205Ile Gly Asp Gly Val Phe Glu Val Leu Ser Thr Asn Gly Asp Thr His

210 215 220Leu Gly Gly Asp Asp Phe Asp Gly Val Ile Ile Asn Trp Met Leu Asp225 230 235 240Glu Phe Lys Lys Gln Glu Gly Ile Asp Leu Ser Lys Asp Asn Met Ala

245 250 255Leu Gln Arg Leu Lys Asp Ala Ala Glu Lys Ala Lys Ile Glu Leu Ser

260 265 270Gly Val Ser Ser Thr Glu Ile Asn Gln Pro Phe Ile Thr Ile Asp Ala

275 280 285Asn Gly Pro Lys His Leu Ala Leu Thr Leu Thr Arg Ala Gln Phe Glu

290 295 300His Leu Ala Ser Ser Leu Ile Glu Arg Thr Lys Gln Pro Cys Ala Gln305 310 315 320Ala Leu Lys Asp Ala Lys Leu Ser Ala Ser Asp Ile Asp Asp Val Leu

325 330 335Leu Val Gly Gly Met Ser Arg Met Pro Ala Val Gln Ala Val Val Lys

340 345 350Glu Ile Phe Gly Lys Glu Pro Asn Lys Gly Val Asn Pro Asp Glu Val

355 360 365Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Gly Gly Glu Val

370 375 380Lys Asp Val Leu Leu Leu Asp Val Ile Pro Leu Ser Leu Gly Ile Glu385 390 395 400Thr Leu Gly Gly Val Met Thr Pro Leu Val Glu Arg Asn Thr Thr Ile

405 410 415Pro Thr Gln Lys Lys Gln Ile Phe Ser Thr Ala Ala Asp Asn Gln Pro

420 425 430Ala Val Thr Ile Val Val Leu Gln Gly Glu Arg Pro Met Ala Lys Asp

435 440 445Asn Lys Glu Ile Gly Arg Phe Asp Leu Thr Asp Ile Pro Pro Ala Pro

450 455 460Arg Gly His Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly465 470 475 480Ile Leu His Val Ser Ala Lys Asp Ala Ala Ser Gly Arg Glu Gln Lys

485 490 495Ile Arg Ile Glu Ala Ser Ser Gly Leu Lys Glu Asp Glu Ile Gln Gln

500 505 510Met Ile Arg Asp Ala Glu Leu His Lys Glu Glu Asp Lys Gln Arg Lys

515 520 525Glu Ala Ser Asp Val Lys Asn Glu Ala Asp Gly Met Ile Phe Arg Ala

530 535 540Glu Lys Ala Val Lys Asp Tyr His Asp Lys Ile Pro Ala Glu Leu Val545 550 555 560Lys Glu Ile Glu Glu His Ile Glu Lys Val Arg Gln Ala Ile Lys Glu

565 570 575Asp Ala Ser Thr Thr Ala Ile Lys Ala Ala Ser Asp Glu Leu Ser Thr

580 585 590His Met Gln Lys Ile Gly Glu Ala Met Gln Ala Gln Ser Ala Ser Ala

595 600 605Ala Ala Ser Ser Ala Ala Asn Ala Gln Gly Gly Pro Asn Ile Asn Ser

610 615 620Glu Asp Leu Lys Lys His Ser Phe Ser Thr Arg Pro Pro Ala Gly Gly625 630 635 640Ser Ala Ser Ser Thr Asp Asn Ile Glu Asp Ala Asp Val Glu Ile Val

645 650 655Asp Lys Pro Glu

660<210>447<211>326<212>PRT<213>沙眼衣原体血清变型D<400>447Met Val Ser Gln Thr Val Ser Val Ala Val Thr Gly Gly Thr Gly Gln

5 10 15Ile Ala Tyr Ser Phe Leu Phe Ser Leu Ala His Gly Asp Val Phe Gly

20 25 30Leu Asp Cys Gly Ile Asp Leu Arg Ile Tyr Asp Ile Pro Gly Thr Glu

35 40 45Arg Ala Leu Ser Gly Val Arg Met Glu Leu Asp Asp Gly Ala Phe Pro

50 55 60Leu Leu Gln Arg Val Gln Val Thr Thr Ser Leu His Asp Ala Phe Asp65 70 75 80Gly Ile Asp Ala Ala Phe Leu Ile Gly Ser Val Pro Arg Gly Pro Gly

85 90 95Met Glu Arg Arg Asp Leu Leu Lys Lys Asn Gly Glu Ile Phe Ala Thr

100 105 110Gln Gly Lys Ala Leu Asn Thr Thr Ala Lys Arg Asp Ala Lys Ile Phe

115 120 125Val Val Gly Asn Pro Val Asn Thr Asn Cys Trp Ile Ala Met Asn His

130 135 110Ala Pro Arg Leu Leu Arg Lys Asn Phe His Ala Met Leu Arg Leu Asp145 150 155 160Gln Asn Arg Met His Ser Met Leu Ser His Arg Ala Glu Val Pro Leu

165 170 175Ser Ala Val Ser Gln Val Val Val Trp Gly Asn His Ser Ala Lys Gln

180 185 190Val Pro Asp Phe Thr Gln Ala Leu Ile Asn Asp Arg Pro Ile Ala Glu

195 200 205Thr Ile Ala Asp Arg Asp Trp Leu Glu Asn Ile Met Val Pro Ser Val

210 215 220Gln Ser Arg Gly Ser Ala Val Ile Glu Ala Arg Gly Lys Ser Ser Ala225 230 235 240Ala Ser Ala Ala Arg Ala Leu Ala Glu Ala Ala Arg Ser Ile Tyr Gln

245 250 255Pro Lys Glu Gly Glu Trp Phe Ser Ser Gly Val Cys Ser Asp His Asn

260 265 270Pro Tyr Gly Leu Pro Glu Asp Leu Ile Phe Gly Phe Pro Cys Arg Met

275 280 285Leu Ala Thr Gly Glu Tyr Glu Val Ile Pro Arg Leu Pro Trp Asp Ala

290 295 300Phe Ile Arg Gly Lys Met Gln Ile Ser Leu Asp Glu Ile Leu Gln Glu305 310 315 320Lys Ala Ser Val Ser Leu

325<210>448<211>232<212>PRT<213>沙眼衣原体血清变型D<400>448Met Thr Lys His Gly Lys Arg Ile Arg Gly Ile Gln Glu Thr Tyr Asp

5 10 15Leu Ala Lys Ser Tyr Ser Leu Gly Glu Ala Ile Asp Ile Leu Lys Gln

20 25 30Cys Pro Thr Val Arg Phe Asp Gln Thr Val Asp Val Ser Val Lys Leu

35 40 45Gly Ile Asp Pro Arg Lys Ser Asp Gln Gln Ile Arg Gly Ser Val Ser

85 90 95Ser Asp Asp Leu Val Glu Lys Ile Lys Gly Gly Trp Val Asp Phe Asp

100 105 110Val Ala Val Ala Thr Pro Asp Met Met Arg Glu Val Gly Lys Leu Gly

115 120 125Lys Val Leu Gly Pro Arg Asn Leu Met Pro Thr Pro Lys Ala Gly Thr

130 135 140Val Thr Thr Asp Val Val Lys Thr Val Ala Glu Leu Arg Lys Gly Lys145 150 155 160Ile Glu Phe Lys Ala Asp Arg Ala Gly Val Cys Asn Val Gly Val Ala

165 170 175Lys Leu Ser Phe Asp Ser Ala Gln Ile Lys Glu Asn Val Glu Ala Leu

180 185 190Cys Ala Ala Leu Val Lys Ala Lys Pro Ala Thr Ala Lys Gly Gln Tyr

195 200 205Leu Val Asn Phe Thr Ile Ser Ser Thr Met Gly Pro Gly Val Thr Val

210 215 220Asp Thr Arg Glu Leu Ile Ala Leu225 230<210>449<211>1252<212>PRT<213>沙眼衣原体血清变型D<400>449Met Phe Lys Cys Pro Glu Arg Val Ser Ile Lys Lys Lys Glu Asp Ile

5 10 15Leu Asp Leu Pro Asn Leu Val Glu Val Gln Ile Lys Ser Tyr Lys Gln

20 25 30Phe Leu Gln Ile Gly Lys Leu Ala Glu Glu Arg Glu Asn Ile Gly Leu

35 40 45Glu Glu Val Phe Arg Glu Ile Phe Pro Ile Lys Ser Tyr Asn Glu Ala

50 55 60Thr Ile Leu Glu Tyr Leu Ser Tyr Asn Leu Gly Val Pro Lys Tyr Ser65 70 75 80Pro Glu Glu Cys Ile Arg Arg Gly Ile Thr Tyr Ser Val Thr Leu Lys

85 90 95Val Arg Phe Arg Leu Thr Asp Glu Thr Gly Ile Lys Glu Glu Glu Val

100 105 110Tyr Met Gly Thr Ile Pro Ile Met Thr Asp Lys Gly Thr Phe Ile Ile

115 120 125Asn Gly Ala Glu Arg Val Val Val Ser Gln Val His Arg Ser Pro Gly

130 135 140Ile Asn Phe Glu Gln Glu Lys His Ser Lys Gly Asn Val Leu Phe Ser145 150 155 160Phe Arg Ile Ile Pro Tyr Arg Gly Ser Trp Leu Glu Ala Val Phe Asp

165 170 175Ile Asn Asp Leu Ile Tyr Ile His Ile Asp Arg Lys Lys Arg Arg Arg

180 185 190Lys Ile Leu Ala Met Thr Phe Ile Arg Ala Leu Gly Tyr Ser Thr Asp

195 200 205Ala Asp Ile Ile Glu Glu Phe Phe Ser Val Glu Glu Arg Ser Leu Arg

210 215 220Leu Glu Lys Asp Phe Val Ala Leu Val Gly Lys Val Leu Ala Asp Asn225 230 235 240Val Val Asp Ala Asp Ser Ser Leu Val Tyr Gly Lys Ala Gly Glu Lys

245 250 255Leu Ser Thr Ala Met Leu Lys Arg Ile Leu Asp Ala Gly Val Gln Ser

260 265 270Leu Lys Ile Ala Val Gly Ala Asp Glu Asn His Pro Ile Ile Lys Met

275 280 285Leu Ala Lys Asp Pro Thr Asp Ser Tyr Glu Ala Ala Leu Lys Asp Phe

290 295 300Tyr Arg Arg Leu Arg Pro Gly Glu Pro Ala Thr Leu Val Asn Ala Arg305 310 315 320Ser Thr Ile Met Arg Leu Phe Phe Asp Ala Lys Arg Tyr Ash Leu Gly

325 330 335Arg Val Gly Arg Tyr Lys Leu Asn Lys Lys Leu Gly Phe Pro Leu Asp

340 345 350Asp Glu Thr Leu Ser Gln Val Thr Leu Arg Lys Glu Asp Val Ile Gly

355 360 365Ala Leu Lys Tyr Leu Ile Arg Leu Arg Met Gly Asp Glu Lys Thr Ser

370 375 380Ile Asp Asp Ile Asp His Leu Ala Asn Arg Arg Val Arg Ser Val Gly385 390 395 400Glu Leu Ile Gln Asn His Cys Arg Ser Gly Leu Ala Arg Met Glu Lys

405 410 415Ile Val Arg Glu Arg Met Asn Leu Phe Asp Phe Ser Ser Asp Thr Leu

420 425 430Thr Pro Gly Lys Ile Ile Ser Ala Lys Gly Leu Val Ser Val Leu Lys

435 440 445Asp Phe Phe Ser Arg Ser Gln Leu Ser Gln Phe Met Asp Gln Thr Asn

485 490 495Ala Ser HiS Tyr Gly Arg Ile Cys Pro Ile Glu Thr Pro Glu Gly Pro

500 505 510Asn Ile Gly Leu Ile Thr Ser Leu Ser Ser Phe Ala Lys Ile Asn Glu

515 520 525Phe Gly Phe Ile Glu Thr Pro Tyr Arg Val Val Arg Asp Gly Ile Val

530 535 540Thr Asp Glu Ile Glu Tyr Met Thr Ala Asp Val Glu Glu Glu Cys Val545 550 555 560Ile Ala Gln Ala Ser Ala Glu Leu Asp Glu Tyr Asp Met Phe Lys Thr

565 570 575Pro Val Cys Trp Ala Arg Tyr Lys Gly Glu Ala Phe Glu Ala Asp Thr

580 585 590Ser Thr Val Thr His Met Asp Val Ser Pro Lys Gln Leu Val Ser Val

595 600 605Val Thr Gly Leu Ile Pro Phe Leu Glu His Asp Asp Ala Asn Arg Ala

610 615 620Leu Met Gly Ser Asn Met Gln Arg Gln Ala Val Pro Leu Leu Lys Thr625 630 635 640Glu Ala Ala Ile Val Gly Thr Gly Leu Glu Gly Arg Ala Ala Lys Asp

645 650 655Ser Gly Ala Ile Ile Val Ala Gln Glu Asp Gly Val Val Glu Tyr Val

660 665 670Asp Ser Tyr Glu Ile Val Val Ala Lys Lys Asn Asn Pro Thr Leu Lys

675 680 685Asp Arg Tyr Gln Leu Lys Lys Phe Leu Arg Ser Asn Ser Gly Thr Cys

690 695 700Ile Asn Gln Thr Pro Leu Cys Ser Val Gly Asp Val Val Thr His Gly705 710 715 720Asp Val Leu Ala Asp Gly Pro Ala Thr Asp Lys Gly Glu Leu Ala Leu

725 730 735Gly Lys Asn Val Leu Val Ala Phe Met Pro Trp Tyr Gly Tyr Asn Phe

740 745 750Glu Asp Ala Ile Ile Ile Ser Glu Arg Leu Ile Lys Gln Asp Ala Tyr

755 760 765Thr Ser Ile Tyr Ile Glu Glu Phe Glu Leu Thr Ala Arg Asp Thr Lys

770 775 780Leu Gly Lys Glu Glu Ile Thr Arg Asp Ile Pro Asn Val Ser Glu Glu785 790 795 800Val Leu Ala Asn Leu Gly Glu Asp Gly Val Val Arg Ile Gly Ala Glu

805 810 815Val Lys Pro Gly Asp Ile Leu Val Gly Lys Ile Thr Pro Lys Ser Glu

820 825 830Thr Glu Leu Ala Pro Glu Glu Arg Leu Leu Arg Ala Ile Phe Gly Glu

835 840 845Lys Ala Ala Asp Val Lys Asp Ala Ser Leu Thr Val Pro Pro Gly Thr

885 890 895Leu Gln Lys Glu Tyr Lys Ser Gln Leu Ala Gln Leu Lys Val Glu His

900 905 910Arg Glu Lys Leu Gly Ala Leu Leu Leu Asn Glu Lys Ala ProAla Ala

915 920 925Ile Ile His Arg Arg Ser Ala Asp Ile Leu Val Gln Glu Gly Ala Ile

930 935 940Phe Asp Gln Glu Thr Ile Glu Leu Leu Glu Arg Glu Ser Leu Val Asp945 950 955 960Leu Leu Met Ala Pro Cys Asp Met Tyr Asp Val Leu Lys Asp Ile Leu

965 970 975Ser Ser Tyr Glu Thr Ala Val Gln Arg Leu Glu Val Asn Tyr Lys Thr

980 985 990Glu Ala Glu His Ile Lys Glu Gly Asp Ala Asp Leu Asp His Gly Val

995 1000 1005Ile Arg Gln Val Lys Val Tyr Val Ala Ser Lys Arg Lys Leu Gln Val

1010 1015 1020Gly Asp Lys Met Ala Gly Arg His Gly Asn Lys Gly Val Val Ser Lys1025 1030 1035 1040Ile Val Pro Glu Ala Asp Met Pro Phe Leu Ala Asn Gly Glu Thr Val

1045 1050 1055Gln Met Ile Leu Asn Pro Leu Gly Val Pro Ser Arg Met Asn Leu Gly

1060 1065 1070Gln Val Leu Glu Thr His Leu Gly Tyr Ala Ala Lys Thr Ala Gly Ile

1075 1080 1085Tyr Val Lys Thr Pro Val Phe Glu Gly Phe Pro Glu Ser Arg Ile Trp

1090 1095 1100Asp Met Met Ile Glu Gln Gly Leu Pro Glu Asp Gly Lys Ser Tyr Leu1105 1110 1115 1120Phe Asp Gly Lys Thr Gly Glu Arg Phe Asp Ser Lys Val Val Val Gly

1125 1130 1135Tyr Ile Tyr Met Leu Lys Leu Ser His Leu Ile Ala Asp Lys Ile His

1140 1145 1150Ala Arg Ser Ile Gly Pro Tyr Ser Leu Val Thr Gln Gln Pro Leu Gly

1155 1160 1165Gly Lys Ala Gln Met Gly Gly Gln Arg Phe Gly Glu Met Glu Val Trp

1205 1210 1215Val Lys Gly Glu Asn Leu Leu Arg Ser Gly Thr Pro Glu Ser Phe Asn

1220 1225 1230Val Leu Ile Lys Glu Met Gln Gly Leu Gly Leu Asp Val Arg Pro Met

1235 1240 1245Val Val Asp Ala

1250<210>450<211>298<212>PRT<213>沙眼衣原体血清变型D<400>450Met Leu Lys Ile Asp Leu Thr Gly Lys Ile Ala Phe Ile Ala Gly Ile

5 10 15Gly Asp Asp Asn Gly Tyr Gly Trp Gly Ile Ala Lys Met Leu Ala Glu

20 25 30Ala Gly Ala Thr Ile Leu Val Gly Thr Trp Val Pro Ile Tyr Lys Ile

35 40 45Phe Ser Gln Ser Leu Glu Leu Gly Lys Phe Asn Ala Ser Arg Glu Leu

50 55 60Ser Asn Gly Glu Leu Leu Thr Phe Ala Lys Ile Tyr Pro Met Asp Ala65 70 75 80Ser Phe Asp Thr Pro Glu Asp Ile Pro Gln Glu Ile Leu Glu Asn Lys

85 90 95Arg Tyr Lys Asp Leu Ser Gly Tyr Thr Val Ser Glu Val Val Glu Gln

100 105 110Val Lys Lys His Phe Gly His Ile Asp Ile Leu Val His Ser Leu Ala

115 120 125Asn Ser Pro Glu Ile Ala Lys Pro Leu Leu Asp Thr Ser Arg Lys Gly

130 135 140Tyr Leu Ala Ala Leu Ser Thr Ser Ser Tyr Ser Phe Ile Ser Leu Leu145 150 155 160Ser His Phe Gly Pro Ile Met Asn Ala Gly Ala Ser Thr Ile Ser Leu

165 170 175Thr Tyr Leu Ala Ser Met Arg Ala Val Pro Gly Tyr Gly Gly Gly Met

180 185 190Asn Ala Ala Lys Ala Ala Leu Glu Ser Asp Thr Lys Val Leu Ala Trp

195 200 205Glu Ala Gly Arg Arg Trp Gly Val Arg Val Asn Thr Ile Ser Ala Gly

210 215 220Pro Leu Ala Ser Arg Ala Gly Lys Ala Ile Gly Phe Ile Glu Arg Met225 230 235 240Val Asp Tyr Tyr Gln Asp Trp Ala Pro Leu Pro Ser Pro Met Glu Ala

245 250 255Glu Gln Val Gly Ala Ala Ala Ala Phe Leu Val Ser Pro Leu Ala Ser

260 265 270Ala Ile Thr Gly Glu Thr Leu Tyr Val Asp His Gly Ala Asn Val Met

275 280 285Gly Ile Gly Pro Glu Met Phe Pro Lys Asp

290 295<210>451<211>298<212>PRT<213>沙眼衣原体血清变型D<400>451Met Ser Leu Gln Lys Leu Leu Val Thr Asp Ile Asp Gly Thr Ile Thr

5 10 15His Gln Ser His Leu Leu His Asp Arg Val Val Lys Ala Leu His Gln

20 25 30Tyr Tyr Asp Ser Gly Trp Gln Leu Phe Phe Leu Thr Gly Arg Tyr Phe

35 40 45Ser Tyr Ala Tyr Pro Leu Phe Gln Asn Phe Ser Val Pro Phe Leu Leu

50 55 60Gly Ser Gln Asn Gly Ser Ser Val Trp Ser Ser Thr Asp Lys Glu Phe65 70 75 80Ile Tyr Phe Arg Ser Leu Ser Arg Asp Phe Leu Tyr Val Leu Glu Lys

85 90 95Tyr Phe Glu Asp Leu Asp Leu Ile Ala Cys Ile Glu Ser Gly Ala Ser

100 105 110Asn Arg Asp Val Tyr Phe Arg Lys Gly Leu Gly Lys Thr Ser Gln Glu

115 120 125Leu Lys Ala Ile Leu Asp Ala Val Tyr Phe Pro Thr Pro Glu Ala Ala

130 135 140Arg Leu Leu Val Asp Val Gln Gly His Leu Ser Glu Glu Phe Ser Tyr145 150 155 160Glu Asp Phe Ala Ile Ala Lys Phe Phe Gly Glu Arg Glu Glu Val Lys

165 170 175Lys Ile Met Asp Arg Phe Ile Gln Ser Pro Glu Val Ser Ser Gln Val

180 185 190Thr Met Asn Tyr Met Arg Trp Pro Phe Asp Phe Lys Tyr Ala Val Leu

195 200 205Leu Leu Thr Leu Lys Asp Val Ser Lys Gly Phe Ala Val Asp Gln Val

210 215 220Val Gln Thr Phe Tyr Lys Glu Asn Lys Pro Phe Ile Met Ala Ser Gly225 230 235 240Asp Asp Ala Asn Asp Ile Asp Leu Leu Ser Arg Gly Asp Phe Lys Ile

245 250 255Val Ile Gln Thr Ala Pro Glu Glu Met His Gly Leu Ala Asp Phe Leu

260 265 270Ala Pro Pro Ala Lys Asp Phe Gly Ile Leu Ser Ala Trp Glu Ala Gly

275 280 285Glu Leu Arg Tyr Lys Gln Leu Val Asn Pro

290 295<210>452<211>153<212>PRT<213>沙眼衣原体血清变型D<400>452Met Leu Arg Leu Phe Gln His Ile Leu Cys Phe Leu Glu Glu Asp Pro

5 10 15Ser Phe Val Asp Val Pro Gln Glu Leu Ser Phe Val Asn Glu Ala Phe

20 25 30Ser Gly Ser Met Arg Trp Glu Val Gly Arg Met Leu Gly Ser Leu Leu

35 40 45Leu Leu Leu Gly Ile Phe Gly Gly Gly Cys Leu Leu Phe Arg Arg Phe

50 55 60Leu Arg Ser Arg Gly His Leu Pro Ser Gly Asn Ser Ser Ile Lys Ile65 70 75 80Leu Asp Gln Arg Val Leu Ala Ser Lys Thr Ser Ile Tyr Val Ile Lys

85 90 95Val Ala Asn Lys Thr Leu Val Val Ala Glu Arg Gly Glu Arg Val Thr

100 105 1l0Leu Leu Ser Glu Phe Pro Pro Asn Thr Asp Leu Asn Glu Leu Ile Gln

115 120 125Lys Asp Gln Lys Lys Pro Ser Thr Pro Arg Gly Glu Met Leu Ser Gly

130 135 140Phe Leu Lys Gln Phe Lys Glu Lys Lys145 150<210>453<211>569<212>PRT<213>沙眼衣原体血清变型D<400>453Met Pro Lys Gln Ala Asp Tyr Thr Trp Gly Ala Lys Lys Asn Leu Asp

5 10 15Thr Ile Ala Cys Leu Pro Glu Asp Val Lys Gln Phe Lys Asp Leu Leu

20 25 30Tyr Ala Met Tyr Gly Phe Thr Ala Thr Glu Glu Glu Pro Thr Ser Glu

35 40 45Val His Pro Gly Ala Ile Leu Lys Gly Thr Val Val Asp Ile Ser Lys

50 55 60Asp Phe Val Val Val Asp Val Gly Leu Lys Ser Glu Gly Val Ile Pro65 70 75 80Met Ser Glu Phe Ile Asp Ser Ser Glu Gly Leu Thr Val Gly Ala Glu

85 90 95Val Glu Val Tyr Leu Asp Gln Thr Glu Asp Asp Glu Gly Lys Val Val

100 105 110Leu Ser Arg Glu Lys Ala Thr Arg Gln Arg Gln Trp Glu Tyr Ile Leu

115 120 125Ala His Cys Glu Glu Gly Ser Ile Val Lys Gly Gln Ile Thr Arg Lys

130 135 140Val Lys Gly Gly Leu Ile Val Asp Ile Gly Met Glu Ala Phe Leu Pro145 150 155 160Gly Ser Gln Ile Asp Asn Lys Lys Ile Lys Asn Leu Asp Asp Tyr Val

165 170 175Gly Lys Val Cys Glu Phe Lys Ile Leu Lys Ile Asn Val Asp Arg Arg

180 185 190Asn Val Val Val Ser Arg Arg Glu Leu Leu Glu Ala Glu Arg Ile Ser

195 200 205Lys Lys Ala Glu Leu Ile Glu Gln Ile Thr Ile Gly Glu Arg Arg Lys

210 215 220Gly Ile Val Lys Asn Ile Thr Asp Phe Gly Val Phe Leu Asp Leu Asp225 230 235 240Gly Ile Asp Gly Leu Leu His Ile Thr Asp Met Thr Trp Lys Arg Ile

245 250 255Arg His Pro Ser Glu Met Val Glu Leu Asn Gln Glu Leu Glu Val Ile

260 265 270Ile Leu Ser Val Asp Lys Glu Lys Gly Arg Val Ala Leu Gly Leu Lys

275 280 285Gln Lys Glu His Asn Pro Trp Glu Asp Ile Glu Lys Lys Tyr Pro Pro

290 295 300Gly Lys Arg Val Arg Gly Lys Ile Val Lys Leu Leu Pro Tyr Gly Ala305 310 315 320Phe Ile Glu Ile Glu Glu Gly Ile Glu Gly Leu Ile His Val Ser Glu

325 330 335Met Ser Trp Val Lys Asn Ile Val Asp Pro Asn Glu Val Val Asn Lys

340 345 350Gly Asp Glu Val Glu Val Val Val Leu Ser Ile Gln Lys Asp Glu Gly

355 360 365Lys Ile Ser Leu Gly Leu Lys Gln Thr Lys His Asn Pro Trp Asp Asn

370 375 380Ile Glu Glu Lys Tyr Pro Ile Gly Leu Arg Val Thr Ala Glu Ile Lys385 390 395 400Asn Leu Thr Asn Tyr Gly Ala Phe Val Glu Leu Glu Pro Gly Ile Glu

405 410 415Gly Leu Ile His Ile Ser Asp Met Ser Trp Ile Lys Lys Val Ser His

420 425 430Pro Ser Glu Leu Phe Lys Lys Gly Asn Thr Val Glu Ala Val Ile Leu

435 440 445Ser Val Asp Lys Glu Ser Lys Lys Ile Thr Leu Gly Val Lys Gln Leu

450 455 460Thr Pro Asn Pro Trp Asp Glu Ile Glu Val Met Phe Pro Val Gly Ser465 470 475 480Asp Ile Ser Gly Val Val Thr Lys Ile Thr Ala Phe Gly Ala Phe Val

485 490 495Glu Leu Gln Asn Gly Ile Glu Gly Leu Ile His Val Ser Glu Leu Ser

500 505 510Glu Lys Pro Phe Ala Lys Ile Glu Asp Val Leu Ser Ile Gly Asp Lys

515 520 525Val Ser Ala Lys Val Ile Lys Leu Asp Pro Asp His Lys Lys Val Ser

530 535 540Leu Ser Ile Lys Glu Phe Leu Val His Gly Gly Asp Ala Gly His Asp545 550 555 560Ala Glu Glu Glu Ser Ser Asp Arg Asp

565<210>454<211>666<212>PRT<213>沙眼衣原体血清变型D<400>454Met Glu Ser Leu Ser Val Arg Ser Thr Ile Pro Leu Pro Leu Gly Ala

5 10 15Lys Lys Leu Ser Ala Asp Arg Tyr Arg Phe Ser Leu Phe Ser Ser Gln

20 25 30Ala Gln Gln Val Thr Leu Val Leu Leu Asp Pro Leu Ser Glu Ile His

35 40 45Glu Ile Pro Leu Ser Ser Thr Asp His Arg Thr Gly Ala Ile Trp His

50 55 60Ile Glu Ile Ala Gly Ile Ser Ser Glu Trp Ser Tyr Ala Tyr Lys Leu65 70 75 80Arg Gly Thr Asp Leu Ser Ser Gln Lys Phe Ala Thr Asp Ser Tyr Ile

85 90 95Ala Asp Pro Tyr Ser Lys Asn Ile Tyr Ser Pro Gln Leu Phe Gly Ser

100 105 110Pro Lys Gln Glu Lys Asp Tyr Ala Phe Ser Tyr Leu Lys His Glu Asp

115 120 125Phe Asp Trp Glu Gly Asp Thr Pro Leu His LeuProLys Glu Asn Tyr

130 135 140Phe Ile Tyr Glu Met His Val Arg Ser Phe Thr Arg Asp Pro Ser Ser145 150 155 160Gln Val Ser His Pro Gly Thr Phe Leu Gly Ile Ile Glu Lys Ile Asp

165 170 175His Leu Lys Gln Leu Gly Val His Ala Val Glu Leu Leu Pro Ile Phe

180 185 190Glu Phe Asp Glu Thr Val His Pro Phe Lys Asn Gln Asp Phe Pro His

195 200 205Leu Cys Asn Tyr Trp Gly Tyr Ser Ser Val Asn Phe Phe Cys Pro Ser

210 215 220Arg Arg Tyr Thr Tyr Gly Ala Asp Pro Cys Ala Pro Ala Arg Glu Phe225 230 235 240Lys Thr Leu Val Lys Ala Leu His Arg Ala Gly Ile Glu Val Ile Leu

245 250 255Asp Val Val Phe Asn His Thr Gly Phe Glu Gly Thr Ser Cys Pro Leu

260 265 270Pro Trp Ile Asp Leu Glu Ser Tyr Tyr Met Val Asn Asp His Gly Asp

275 280 285Leu Met Asn Phe Ser Gly Cys Gly Asn Thr Val Asn Thr Asn Thr Pro

290 295 300Thr Thr Leu Lys Trp Ile Leu Asp Ala Leu Arg Tyr Trp Val Gln Glu305 310 315 320Met His Val Asp Gly Phe Arg Phe Asp Leu Ala Ser Val Phe Ser Arg

325 330 335Asp Pro Gln Gly Val Pro Leu Pro Leu Thr Pro Ile Leu Gln Ala Ile

340 345 350Ser Ser Asp Ser Ile Leu Ser Glu Thr Lys Leu Ile Ala Glu Pro Trp

355 360 365Asp Ala Gly Gly Leu Tyr Gln Leu Gly His Phe Pro Ser Ile Ser Thr

370 375 380Arg Trp Ser Glu Trp Asn Gly Cys Tyr Arg Asp His Val Lys Ala Phe385 390 395 400Leu Asn Gly Asp Ala His Gln Val Ser Ser Phe Ala Ser Arg Ile Ser

405 410 415Gly Ser His Asp Ile Tyr Pro Asn Gly Lys Pro Thr Asn Ser Ile Asn

420 425 430Tyr Ile Cys Ser His Asp Gly Phe Thr Leu Tyr Asp Thr Val Ala Tyr

435 440 445Asn Asp Lys His Asn Glu Glu Asn Gly Glu Tyr Asn Arg Asp Gly Thr

450 455 460Ser Ala Asn Tyr Ser Tyr Asn Phe Gly Cys Glu Gly Glu Thr Thr Asp465 470 475 480Pro Thr Ile Cys Ala Leu Arg Glu Arg Gln Met Lys Asn Phe Phe Leu

485 490 495Ala Leu Phe Leu Ser Gln Gly Ile Pro Met Ile Gln Ser Gly Asp Glu

500 505 510Tyr Gly His Thr Ala Tyr Gly Asn Asn Asn His Trp Cys Leu Asp Thr

515 520 525Lys Ile Asn Tyr Phe Leu Trp Asp Arg Leu Ala Glu Arg Lys Glu Leu

530 535 540Phe Ser Phe Leu Cys Gln Val Ile Ala Leu Arg Lys Ala Tyr Thr Glu545 550 555 560Leu Phe Asn Thr Ser Phe Leu Ser Glu Asp Thr Ile Thr Trp Leu Asn

565 570 575Thr Lys Gly Ser Pro Arg Glu Trp Gly Ala Asp His Tyr Leu Ala Phe

580 585 590Glu Leu Lys His Leu Asn Tyr Ser Leu Phe Val Ala Phe Tyr Ser Gly

595 600 605Asn Glu Arg Ile Glu Ile Ser Leu Pro Lys Pro Arg Lys Glu His Leu

610 615 620Ala Tyr Glu Lys Ile Val Asp Ser Thr Thr Gly Phe Phe Ser Gln Ile625 630 635 640Leu Ser Pro Lys Leu Ser Leu Glu Pro Tyr Ser Ser Leu Val Ala Ile

645 650 655Ser Arg Arg Lys Thr Ser Leu Glu Ser Arg

660 665<210>455<211>882<212>DNA<213>肺炎衣原体<400>455gtgtccaaac atacttctga atccaggatt gctcaagata tgttagaacg ttattctggc 60tctagcgtaa agcaattttg tccttatctc ttactcacga acttctctta ctatatccaa 120acctttgcaa aacttcatgg ggtgcccgtc tttgagggtt ctatgttttc tgctgcccat 180gctcctcatc ttaaaacttc aattttagat tttaaactag ggtctccagg agctgcatta 240actatagact tatgttcatt tcttcctgat ctcaaagcag cgcttatgtt aggaatgtgt 300gggggcttac gctctcatta tcaggttgga gattactttg tccccgtagc tagcatacgt 360ggagagggta cttcagacgc ctatttccct cctgaagttc cggctcttgc aaattttgtt 420gtacagaaag caacaactga agttttagaa gataagaagg caaactacca tattggcatt 480acccacacga ccaacattcg cttttgggaa tttaacaaaa aatttagaaa aaaactgtac 540gaaaccaaag ctcaatccgc tgaaatggag tgtgcgacac tttttgctgc cggataccgt 600agaaacctgc ccattggagc gttattattg atttcagatc ttcccttaag gaaggaggga 660atcaaaacga agtccagtgg gaacttcatc tttaatactt atacggaaga ccacatctta 720acaggacaag aagtcataga gaaccttgaa aaagtcatgc taaaacgagc agcttctgac 780cataagaagg atcaacagta tcgaggatta cctcatatgg aagttggaga agccgatgac 840actatggcta gcggctctga aacttccgac agtgactatt ga 882<210>456<211>1185<212>DNA<213>肺炎衣原体<400>456atgtcaaaag aaacttttca acgtaataag ccccatatca atattgggac gatcgggcac 60gttgaccatg gtaaaactac gctaacagcg gcaattacac gcgcgctatc aggggatgga 120ttggcctctt tccgtgacta tagttcaatt gacaatactc cagaagaaaa ggctcgtgga 180attactatca acgcttctca cgttgaatac gaaaccccaa atcgtcacta cgctcacgta 240gactgccctg gtcacgctga ctatgttaaa aatatgatta caggcgccgc tcaaatggac 300ggagctatcc tagtcgtttc agctacagac ggagctatgc cacaaactaa agaacatatc 360ttgctagctc gccaggttgg agttccttat atcgttgttt tcttgaataa agtagatatg 420atctctcaag aagatgctga acttattgac cttgttgaga tggaacttag tgagcttctt 480gaagaaaaag gctacaaagg atgccctatt atccgtggtt ctgctttgaa agctcttgaa 540ggtgatgcaa attatatcga aaaagttcga gaacttatgc aagctgtgga tgacaacatc 600cctacaccag aaagagaaat tgataagcct ttcttaatgc ctatcgaaga cgtattctca 660atctctggtc gtggtactgt ggttacagga agaatcgagc gtggaatcgt taaagtttct 720gataaagttc agctcgtggg attaggagag actaaagaaa caatcgttac tggagtcgaa 780atgttcagga aagaacttcc tgaaggtcgt gcaggagaaa acgttggttt actcctcaga 840ggtattggaa agaacgatgt tgaaagaggt atggtggttt gtcagcctaa cagcgtgaag 900cctcatacga aatttaagtc agctgtttac gttcttcaga aagaagaagg cggacgtcat 960aagcctttct tcagcggata cagacctcag ttcttcttcc gtactacaga cgtgacagga 1020gtcgtaactc ttcctgaagg aactgaaatg gtaatgcctg gagataacgt tgagcttgat 1080gttgagctca ttggaacagt tgctcttgaa gaaggaatga gatttgcaat tcgtgaaggt 1140ggtcgtacta tcggcgctgg aacgatttca aagatcaatg cttaa 1185<210>457<211>1656<212>DNA<213>肺炎衣原体<400>457atgccacaaa aagtcctgat tacttcagct ttaccctatg ctaatggtcc gctacatttt 60ggacatattg caggagtcta tcttcctgca gatgtgtatg caagattccg tagattgtta 120ggagacgatg tcctttatat ttgtggttcc gatgaatttg gcatagcgat caccttaaat 180gcggatcgtg aggggttggg gtatcaagag tacgtggata tgtaccataa gttacataaa 240gatacttttg agaagttagg gtttgctttg gatttctttt ctaggacgac gaaccctttt 300catgctgagc ttgtccaaga tttttattcc caacttaaag cgtctggatt gattgaaaat 360cgcatatctg aacaactgta ttcagaacaa gaacaacgtt ttcttgcgga tcgttatgta 420gaagggacgt gtcctcggtg cggttttgat catgctcgag gagacgagtg tcagagctgt 480ggtgcggatt atgaggctat agatttaatc ggccctaagt ctaagatttc tggggttgag 540ttagtaaaaa aagagactga gcactcatat tttcttttgg accgtatgaa agacgctcta 600ctttctttta ttcagggatg ctatttacct gatcatgtcc gtaaatttgt tgttgattac 660atagaacatg tcaggtctcg agccattact cgagatttat cttgggggat tcctgttcca 720gactttcctg gaaaggtgtt ttatgtatgg tttgacgctc ctataggata tatcagtgga 780actatggaat gggcagcttc tcaaggaaac cctgacgaat ggaagcgttt ctggcttgaa 840gacggtgtag agtatgtcca gtttataggt aaagataatc ttcctttcca ttctgtagtt 900ttcccagcta tggaattggg tcagaaactt gactataaaa aagttgatgc cctcgtagtt 960tcagagtttt atcttttaga aggacggcaa ttcagtaaat ccgagggcaa ttatgtggat 1020atggacaagt ttttgagttc ctattcctta gacaaattgc gctatgtatt ggcggctaca 1080gctcctgaaa cttcggatag tgagtttact ttccttgatt ttaagactcg ttgtaattct 1140gagttggtag gaaagtttgg gaattttata aaccgagttc ttgcttttgc agaaaagaat 1200cactatgaca agctttctta tcattctgtg gttttagaag atagtgacag ggcatttctt 1260gaagaagcgc gtcaacttgt tcgagatgct gagaagtgct acagagagta tagtttacgt 1320aaggctacga gtgtgattat gtcactggca gctttaggga atgtctattt taaccaacaa 1380gcaccttgga agctattgaa agaagggact cgtgagcgtg ttgaggccat tttattctgc 1440gcatgttatt gtcagaagtt gttagcttta atttcttatc ctattattcc cgaaagcgct 1500gtagctattt gggagatgat ctcaccaaaa tctttagaaa attgcaattt ggatacgatg 1560tatgctaggg atctatggaa agaagaaatt cttgatgtta taaacgaaga atttcatttg 1620aagtccccca ggttattatt tactactgta gagtag 1656<210>458<211>294<212>DNA<213>肺炎衣原体<400>458atgattaaaa aagatcgttt cactaatgaa aagttaaata agcttttcga tagtcctttt 60agcctagtga actacgcgat taaacaagca aagatcaaaa ttgccaaagg cgatgttcgc 120tcctctaatg ttgcgatcga aacactcgtc ttgttagata gagaagggat acagcctgag 180tttactgaag agattgtagt aactgctagc cctactgtgg aaagaaagag atcagaacat 240acaaattcta gaaaaaaaga tccctcagca tatacttgga gtgatgtaaa gtaa 294<210>459<211>618<212>DNA<213>肺炎衣原体<400>459atgaataaga tcctagttga ctctcctttt tctccagatc accagaagtg ctgtcctaag 60ctttttacaa ttagtgctcc tgctggagtt ggaaagacaa cacttgtccg tatgttagag 120caagagtttt cttctgcttt tgctgagact atatcggtaa caacaaggaa acctcgagag 180ggtgaagtcc caggtaaaga ttatcatttt gtttcccacg aagaatttca aagacttttg 240gatcgtcagg ctctcttaga atgggtgttc ttattcggag agtgttacgg aacaagtatg 300ttagagattg aaagaatttg gagcctaggg aagcacgctg ttgctgttat tgatatccaa 360ggagccttgt ttattcgctc tcggatgcct agtgtatcta tttttattgc tccaccttca 420caggaggagt tagaaagaag gttagcttca cggggatctg aagagggctc tcaaagaaaa 480gaacggctgg agcacagtct tattgagcta gcagctgcaa atcagtttga ttatgtcatt 540attaacgacg acttaaatca agcgtacagg gttttaaaaa gcatttttat agctgaagaa 600cataggaaca tattatga 618<210>460<211>1809<212>DNA<213>肺炎衣原体<400>460ttgaaagaat ataagataga gaacattcgc aatttttcaa tcatagcgca tattgatcac 60gggaagtcta caattgctga tcgcctttta gaaagtacga gcacagtaga agaacgggag 120atgcgtgagc agctcttaga ttccatggat cttgaaagag agcgtggcat tacaattaaa 180gctcatcctg tcaccatgac gtatctatat gaaggagagg tgtatcaact gaacctgatt 240gatacccctg gtcacgtgga cttttcgtat gaagtctctc gatctctatc tgcatgtgag 300ggcgccttac ttattgtaga tgccgcccag ggggtgcagg cacaaagtct tgctaatgtc 360tacctggccc ttgaaagaga tttagagatc attcctgtat taaacaagat tgatctacct 420gccgctgatc ccgtgagaat tgctcaacag attgaagatt atataggcct agacactacg 480aacattattg cctgttctgc aaaaacaggt caggggatcc ctgcaatcct gaaagcaatt 540atcgatcttg ttcctcctcc aaaagcacct gcagaaacag agcttaaagc tttagtcttt 600gattctcatt atgaccctta cgttggcatt atggtctacg tacgcattat tagcggggaa 660ttaaaaaaag gagaccgcat tacttttatg gcggctaaag gctcctcgtt tgaagtctta 720ggtatagggg cctttctccc taaagcaaca tttatagaag gttccttacg ccctggtcag 780gtgggttttt ttattgccaa tctcaaaaaa gtgaaggatg tgaagatcgg cgatacagtc 840acgaaaacaa aacatcctgc aaaaactcct ttggaaggct tcaaagagat caatccggta 900gtttttgctg gaatttatcc tatagattct tctgattttg atactttgaa agatgcttta 960ggaagactac agctcaatga ttctgcttta actatagaac aagaaagcag tcactcttta 1020ggctttggtt ttcgttgtgg cttcttagga cttcttcatc ttgagattat ctttgaaaga 1080atcattcgag aatttgactt agatattatt gcaacggctc caagtgtcat ctataaagtc 1140gtcttaaaaa acgggaaagt tctagatatt gataacccct caggatatcc ggatcctgcg 1200atcatcgagc atgtggaaga gccttgggtt catgtgaata ttatcacccc tcaagaatat 1260ctgagcaaca ttatgaacct ctgtttagat aaacgtggga tctgcgtaaa aacagaaatg 1320ctagatcagc accgtctagt tcttgcttac gaactccctt taaatgagat tgtctcggat 1380ttcaatgaca agctgaagtc agtaactaaa ggttatggat cctttgacta ccgtcttggg 1440gattaccgta agggatcgat catcaaatta gaggttctta ttaacgagga gcccatagat 1500gctttttctt gtttagtcca tagagataaa gcagaatctc gtggaagaag tatctgcgaa 1560aagcttgtgg acgtgattcc acaacaactc ttcaagattc ccatccaagc tgccattaac 1620aaaaaagtca ttgccagaga aacgattcgt gcgctttcta agaacgtgac cgcaaagtgt 1680tatggcggag atattactag gaaacgcaag ctgtgggaaa agcaaaagaa aggaaaaaaa 1740cgtatgaagg aatttggaaa agtttccatt cccaatacag ctttcattga agttctaaaa 1800ttagattaa 1809<210>461<211>975<212>DNA<213>肺炎衣原体<400>461atggaacttc ttccacacga aaaacaagta gttgaatatg aaaaggctat agccgaattt 60aaagaaaaaa ataagaaaaa ttctctctta tcttcttcag agattcagaa attggaaaag 120cgtttagata aattaaaaga aaagatctat tcggatttga ctccttggga gcgtgtacaa 180atatgtcgcc acccttcgcg tccccgtact gtcaactata ttgaagggat gtgtgaggag 240tttgtcgagc tttgtggaga tcgcaccttc cgagatgatc ccgcagttgt tggtggcttt 300gtaaaaatcc agggtcagcg ttttgtcctt attggccaag aaaagggatg cgatacagcg 360tcacgccttc ataggaactt cggtatgtta tgtcccgagg gtttcagaaa agcccttcgc 420ttaggaaaac tcgctgaaaa gtttggcttg cctgtggtct ttcttgtcga taccccagga 480gcatatcctg gattgactgc tgaagagaga ggacaaggat gggcaattgc caaaaatctt 540tttgagctct caagacttgc cactcccgtg attattgtcg ttatcggtga gggatgttca 600ggtggagctt tgggcatggc tgtaggtgat tctgtagcta tgttagagca ttcctattat 660tctgtaattt ccccagaagg atgcgcctcc attctttgga aagatcctaa gaaaaatagc 720gaagcagctt ccatgttgaa aatgcatgga gaaaacttaa aacaatttgg cattatcgat 780actgttatca aagagcccat tgggggagct caccacgatc ctgcattggt atatagcaat 840gttcgagagt ttatcatcca agagtggtta cgattaaaag atctagctat agaagagctg 900ttggagaaac ggtacgaaaa atttcgctct ataggtcttt atgaaactac ttctgaaagc 960ggtcctgagg cataa 975<210>462<211>1980<212>DNA<213>肺炎衣原体<400>462atgaaactac ttctgaaagc ggtcctgagg cataaaaatc atctcgttat attaggctgt 60tctctactcg caattttagg acttaccttt tcatctcaga tggagatttt ttctttaggg 120atgattgcta aaacaggccc cgacgccttt ttactttttg gacgtaagga atctggaaaa 180cttgtaaagg tttcagaact aagtcagaaa gatattttag agaattggca ggcaattagt 240aaggattcag agacacttac agtctctgat gccacgacat acatcgccga acatgggaaa 300agcacagcct ctctgacgag caagctctct aagtttgtcc gtaactacat cgatgtgagc 360cgctttcgag gactggcaat cttcttaatc tgcgttgcta tttttaaagc agtcacctta 420tttttccaac gtttccttgg gcaagtcgtt gctatacggg taagccgaga cttacgtcag 480gactacttta aggccctaca acaactcccc atgaccttct tccatgatca tgatatcggt 540aatttaagta atcgtgtcat gacagattct gcaagcattg ccttagcagt aaactcttta 600atgattaact acattcaagc cccaattacc ttcatattga cattgggagt ctgtctgtcg 660atttcatgga agttttcaat tcttatttgt gttgcctttc ctatctttat ccttcccatt 720gtcgtgatcg ctagaaagat caaaaattta gcaaaacgta ttcaaaagag tcaggattca 780ttttcctccg ttctttatga ttttcttgct ggggttatga cagtaaaagt ctttcgtaca 840gaaaaatttg ccttcacaaa atattgtgag cataacaata agatttctgc tttagaggag 900aaaagtgctg cttacggttt gcttccacga cccctcctgc ataccatagc ttctttattt 960tttgcttttg tcgtcgttat cggaatttat aaatttgcta ttcctcccga agaacttatc 1020gtattttgtg gtttgctcta cctaatctac gaccctatta agaagttcgg ggatgaaaat 1080acctccatca tgaggggatg tgctgctgcg gagagatttt atgaagtctt gaatcacccc 1140gatcttcata gtcaaaaaga aagagaaatc gagttccttg gactttctaa tacaatcaca 1200ttcgagaatg tttccttcgg ctatcaggaa gataagcaca tcctcaaaaa tctaagcttt 1260accttacata aaggcgaagc tctaggcatt gtaggaccta caggatctgg aaaaacaaca 1320cttgttaaat tacttcctag gctctacgaa gtctcccaag gaaagattct tatcgactct 1380cttcctatta cggaatataa caaagggtcc ttaaggaatc acatcgcctg tgtattacag 1440aatcctttct tattctatga tactgtatgg aataacctta cctgtggtaa ggatatggag 1500gaggaggctg ttttagaagc tctaaaacgt gcctacgctg atgagtttat tttaaagctc 1560cctaaaggag tccatagcgt gctcgaagaa tctgggaaga atctctcagg aggacagcag 1620caacgtttgg caatagcacg tgctctgttg aaaaacgcct ccatcttaat tttagatgag 1680gcaacgtcag ctctagatgc cattagtgaa aattacatta agaatatcat tggagagctt 1740aaaggacagt gcacacaaat cattattgcc cacaagctga ccactcttga acatgtagat 1800cgcgtgctct acatagaaaa tggtcaaaaa attgccgaag gcacaaaaga agaactctta 1860cagacgtgtc ctgaattttt aaaaatgtgg gagctctcag ggactaaaga atataacagg 1920gtctttgttc ctgatcacaa attagtcgca aatcctacgg acatggcaat aacaacttag 1980<210>463<211>1236<212>DNA<213>肺炎衣原体<400>463atgattccta ccatgttaat gttcttcatt atctgtttta ctttatgctc gggattcatt 60tcgttatctc aaattgcttt gttttctttg cctacgagtt tgatctcgca ctataagcgc 120tctaaatcta agaaacagca gcgagtagct acccttcttc tacatcccca ccacctgctc 180atcaccttaa ttttttgtga tatcggactg aatattgcta ttcaaaactg ttttgccatt 240ctatttggag atgcagcttc gtggtggttt actgtaggtc ttcctttagc aattactttg 300atcttaggtg agattctccc taaagcagta gctcttcctt ttaatacaca gattgctagt 360tccgtagccc ctcttattct ttgtgttact aaaatcttca aacccctact ccactggggt 420atcgtaggaa ttaattatgt ggtccaatgg attttatcga agcaacagat tgatatcatc 480caaccccaag agctgaagga agtattgcaa agttgtaagg atttcggcgt agtcaatcaa 540gaagaaagcc gtttactcta tggttatctt tctcttagtg attgtagtgt taaagagcgt 600atgcagccac gccaggatat tttattttat gatatccaaa cccctttaga gaacctctat 660cttttatttt ctaaacagca ttgctcacga gttcctatat gtaacgataa cctccaaaac 720cttctgggca tttgcacagc gcgctctctt cttttacatg acaagccact gcaatcttcg 780gatgatctcc tccccttgct gaaaaaaccg tattatatgc cagaaaccat ctctgcaaaa 840atggctttat gtcagatggc agctgaagac gaaaccctag ggatgatcat tgatgaatac 900ggatctattg aaggattgat cactcaagaa gacctctttg aaattgttgc tggagaaatt 960gtagaccaga gagataataa aatactctat accacctcag gagctgatgt tattattgcc 1020tcaggaactt tagaactccg tgagtttagt gagatcttcg atatcaacct accgacgaac 1080aataatattg cgactatagg aggctggtta atagagcaaa tcggaacgat tccgacaaca 1140ggaatgaaac tctcttggaa taacttgctt ttccaggtat tagacgctgc tccgaatcgc 1200attcgccgtg tgtatataag gaaattgtat gactaa 1236<210>464<211>1215<212>DNA<213>肺炎衣原体<400>464atgactaatt ctgctctctt ttggatagga gtcaacatta tctgtattgt cttacaagga 60ttctattcga tgatggaaat ggcctgcgtg tcatttaacc gtgtacgatt gcaatactat 120ctgactaaag atcataagaa agctcgctac attaatttcc tgattcgccg cccctatcgt 180ttatttggaa cggtgatgtt aggagtgaat atcgctctac aagtcgggtc tgagtcctca 240agaaattgct atcgagcttt aggaatcact ccagattacg ctcctttcac tcaaattttt 300atagttgtga tttttgcaga acttctacct ctaacaatat cacggaagat tcctgaaaaa 360ttagcacttt ggggagcacc gattctctat tattcccact atattttcta tcctctgatt 420cagctcatag gaagtctcac tgagggtctt tactatcttc taaatattag gaaagaaaaa 480ttgaactcta cattaagtag agacgagttc caaaaagctt tagagactca ccatgaagaa 540caagatttca atacaattgc tacaaatatt ttctctttaa gtgcgacttg tgcagatcag 600gtatgccaac ctttagaaca ggttaccatg cttccttctt ctgcaaatgt taaagatttt 660tgccggacta taaaaaatac agatatcaac tttattcctg tctatcacaa ggcccgaaaa 720aacgttattg ggattgccca tcctaaagac tttgtcaata aagctcttga tgaaccccta 780atcaataatc tacactcgcc ttggtttatc actgcaaaat caaaacttat tcgtatcctc 840aaagagtttc gagacaaccg ttcgagtgtt gctgttgtcc tcaatgcttc tggtgaacct 900ataggtattc ttagtttaaa tgcaattttc aaaatcttat tcaacactac aaacattgct 960catttaaaac ccaagaccat ctctgttatt gaaagaacgt ttcctggcaa ctctcgcata 1020aaagatctgc aaaaagaact cgatattcaa tttccgcaat atcctgtaga aaccctagcc 1080caattggtat tgcaactgct agacagtcct gcagaagtag gaacttctgt aattatcaac 1140aacttgcttt tagaagttaa agagatgtct ttatctggga taaaaaccgt atcgattaaa 1200aacttactct catag 1215<210>465<211>1632<212>DNA<213>肺炎衣原体<400>465ttgttcggct cggagtccct ccgttatcaa ttgttgatcc aagattttgc aaaagtttca 60gaagagggca taggcctttt ggagtctaaa gagtattctt tacttcaggc taagctagtt 120ttaagggctc tggctcaaaa ttcttctttt gatgattggt ttagaagttt taagaagtgt 180cagatttcct atccagagtt agctcatgat cgcgatgtct tagaagaatt tgggattcaa 240gttctgcgtg agggaatcga aaatccttcc gtgaccgttc gtgctgtgag tgtccttgct 300attgggcttg ctagagattt tcgcttggtc cctctcctgc tccaaagttg taatgatgac 360agtgctattg ttcgatcttt ggctcttcag gttgctgtga actatggctc tgaaagttta 420aaaaaggcca ttgtagagct tgcccgtaat gatgattcta ttcatgttcg gattacagca 480tatcaggtgg tcgctctttt acagatagag gagctattgc catttttaag agagcgtgct 540gagaacaaac ttgtagatag tgtagaacgt cgagaggcgt ggaaggcttg cttggaactc 600tcttctcaat ttctagagac gggtgtagct aaggacgata ttgatcaagc gttgttcact 660tgtgaagtgt tgcgtaacgg tatgttgcca gagactactg agatttttac agaactctta 720tctgtagagc atcctgaagt gcaggagtct ctcttacttt ctgctttagc ttggagtcat 780cagctacaga atcacaaaga gtttcttagt aaagtgcgcc atgtgatgtg cacttctcca 840tttgcaaaag tacgttttca agctgctgca cttctccatc tgcatggaga ccctttgggc 900agagactctc tggttgaggg cttgcgctct cctcaacctc ttgtgtgtga ggcagcttcg 960gcggctctct gctctttagg aatccatgga gtccctttgg caaaggagca tttggagagc 1020ctttcttctc gaaaggctgc tgcgaacctc tccattttgc ttcttgtgag ccgtgaagat 1080attgaaagag ctggagatgt gattgctcgc tacctctcca atcctgaaat gtgctgggct 1140atagagtatt tcttatggga tgcacaatgg aatttacgtg gtgatacctt ccctctatat 1200tcggatatga ttaaacgtga gattggtagg aagctcattc gccttttggc agtagctcgc 1260tatagccaag ccaaggctgt aacagcaacg ttcctttcag gacagcaagc tcagggatgg 1320agcttttttt ctggaatgtt ctgggaagag ggagatgtga aaacttctga ggatttggtt 1380acagatgctt gctttgcagc aaagttggaa ggagcgttag cctcgctatg tcagaaaaaa 1440gatcaagctt ccctacagag ggtctctcaa ctttataatg acagccgttg gcaagataaa 1500ttagcaatct tagagagcgt tgctttttct gagaatcttg atgctgtgcc ttttcttcta 1560gactgctgcc atcacgaagc tccttcgctg cgaagtgcag cagcgggtgc tcttttctct 1620attttcaaat aa 1632<210>466<211>312<212>DNA<213>肺炎衣原体<400>466atgtcattta aacgtttctt gcaacagatc cctgtacgta tctgtctact tattatctat 60ctctaccaat ggcttatctc ccctctctta ggctcgtgct gtagattttt tccttcctgt 120tcgcactatg cagaacaagc cttaaaatct cacggcttcc tgatgggctg ctggctttct 180ataaagagaa tcggaaagtg tggcccctgg catcctggag gcattgacat ggtccctaag 240actgctttgc aggaagtttt agaaccttac caggaaatag acggtggtga ttcaagccat 300ttttctgaat ga 312<210>467<211>1089<212>DNA<213>肺炎衣原体<400>467atggctttca aaagaaaaac tagatggctg tggcaagtct tgatcctgag tgtgggattg 60aatatgcttt ttttgctctt attttactct gccatatttc gtaaagacat ctataagctg 120catttatttt ccggaccttt gattgcgaaa agtagtcgta aggtctacct ttctgaagat 180tttttaaacg agatatctca agcatctttg gacgacttga tttcgttgtt caaagatgag 240cgctatatgt atggtcggcc gataaaactt tgggcgttga gtgtagcgat agcttcccac 300cacatagaca tcactcctgt gctttcgaag cctttgacct atacagagtt gaaaggatct 360tcagtgcggt ggcttttgcc gaatattgat cttaaagact ttcctgtgat tttggactat 420ttgcgttgcc acaagtatcc ctatacttct aagggcttgt ttttgctgat agaaaagatg 480gtacaagaag gctgggtaga tgaagattgc ctgtatcatt tctgctcgac tccagaattt 540ctttacttgc gtacgttact tgtaggtgca gacgtgcagg cctcttcagt agcctcatta 600gctcgtatgg tgattcgttg cggatccgaa cgtttctttc atttttgcaa tgaagagagc 660cgcacttcca tgatttcagc tacacaacgt cagaaagtct taaaatctta tttagattgt 720gaagaatctc tggcagcctt gcttttgctt gtccatgata gtgatgttgt tttgcatgaa 780ttttgtgatg aagatcttga gaaggtcatc cgcctgatgc ctcaagagtc tccctatagt 840cagaatttct tctctcgatt acagcattct ccgcgtagag agttggcctg catgtcgact 900cagagggtag aggctcctcg tgttcaagaa gatcaggatg aagagtatgt ggtacaggac 960ggggattctt tatggttgat agctaagagg tttggcattc ctatggataa gatcattcag 1020aaaaatggct tgaatcacca ccgtctattt cctggtaagg ttctaaaact tcctgcaaag 1080cagtcttag 1089<210>468<211>1308<212>DNA<213>肺炎衣原体<400>468atgttttcac gatggatcac cctcttttta ttattcatta gccttactgg atgctcctcc 60tactcttcaa aacataaaca atctttaatt attcccatac atgacgaccc tgtagctttt 120tctcctgaac aagcaaaacg ggccatggac ctttctattg cccaacttct ttttgatggt 180ctgactagag aaactcatcg cgaatccaat gatttggaat tagcgattgc cagtcgctat 240acagtctctg aagacttttg ctcttatacg ttctttatca aagacagcgc tttatggagc 300gacggaacac caatcacctc cgaagatatc cgtaacgctt gggagtatgc acaggagaac 360tctccccaca tacagatctt ccaaggactt aacttctcaa ctccttcatc aaatgcaatt 420acgattcatc tcgactcgcc caaccccgat tttcctaagc ttcttgcctt tcctgcattt 480gctatcttta aaccagaaaa cccgaagctc tttagcggtc cgtatactct tgtagagtat 540ttcccagggc ataacattca tttaaagaaa aaccctaact attacgacta ccactgcgtc 600tccatcaact ccatcaaact gctcattatt cctgatatat atacagccat ccacctccta 660aacagaggca aggtggactg ggtaggacaa ccctggcatc aagggattcc ttgggagctc 720cataaacaat cgcaatatca ctactacacc tatcctgtag aaggtgcctt ctggctttgt 780ctaaatacaa aatccccaca cttaaatgat cttcaaaaca gacatagact cgctacttgt 840attgataaac gttctatcat tgaagaagct cttcaaggaa cccaacaacc agcggaaaca 900ctgtcccgag gagctccaca accaaatcaa tataaaaaac aaaagcctct aactccacaa 960gaaaaactcg tgcttaccta tccctcagat attctaagat gccaacgcat agcagaaatc 1020ttaaaggaac aatggaaagc tgctggaata gatttaatcc ttgaaggact cgaataccat 1080ctgtttgtta acaaacgaaa agtccaagac tacgccatag caacacagac tggagttgct 1140tattacccag gagcaaatct aatttctgaa gaagacaagc tcctgcaaaa ctttgagatt 1200atcccgatct actatctgag ctatgactat ctcactcaag attttataga gggagtaatc 1260tataatgctt ctggagctgt agatctcaaa tatacctatt tcccctag 1308<210>469<211>1749<212>DNA<213>肺炎衣原体<400>469gtgtctggga agaaagatgg tgtaagggga atgatctttg tccctcttag catcctagta 60ctaatctttt tacctcttcc tcagatcctt cttgattttg gattgtgtat tagttttgca 120ttgtctttac taacggtctg ttgggtcttt accttaaatt caagcaattc agcgaagctt 180tttcctccat ttttcttata tctttgccta ttgcggttgg gattgaatct tgcatcaaca 240cgatggattg tctcttcagg aaccgcctct tctctgattg tttctttagg cagtttcttc 300tctttaggaa gtctatgggc agcaacgttt gcgtgcctcc ttcttttctt tgtgaacttt 360ttgatggttt caaagggttc ggaaagaatc gcagaggtcc gttcgcggtt tttcttagag 420gctcttccag caaaacagat ggctttagat tctgatcttg tttctggaag agcttcttat 480aaggctgtca aaaaacaaaa aaatgccctt atagaagaag gggatttctt ctctgccatg 540gagggggtct ttcgttttgt taaaggggat gcaattatta gttgtatcct tttactcgtg 600aacgtagttt ctgtaacttg tctttattat acttcgggtt atgctcttga gcagatgtgg 660tttacagttt taggagatgc tttagtgagt caagtacctg ctttacttac ttcgtgtgct 720gcagccactc ttattagtaa aatcgataag gaagagagcc ttttaaatta cctgttcgaa 780tactacaaac agttgcgtca gcatttcagg gtggtgtcgt tattgatctt ttctttgtgc 840tgcattccca gttctccaaa attccctatc gttttgctcg cgagtctttt atggttggcg 900tatcgaaaag aagagcctgc atcagaagat tcttgtatag aacgtgcgtt ctcttatgtt 960gagggggcct gccctaagga acaagaatca cagttctatc aagtatatcg tgcagcatcc 1020gaagaagtat ttgaagattt aggagttaga ttgcctgtgc ttacttctct acgtattgaa 1080gagcgtcctt ggctccgagt atttggccag aatgtatact tagatgaaat gactccagag 1140gctgtgcttc ctttccttag aaacatcgct catgaggctc tcaatgccga ggtagttcaa 1200aagtaccttg aggaatcaga gagagtgttt ggcatcgctg ttgaagacat cgttcctaag 1260aaaatctctt taagctctct tgtagttctt tctcgcctcc ttgttagaga aagggtatcg 1320cttaagcttt tcccaaagat tctagaggcc gttgcggtat accaaaattc tggagacagc 1380ttggagatcc ttgcggaaaa agtgcgaaag tctctcggat attggattgg gagaagtctc 1440tgggatcaga aacaaaccct tgaggtaatt accatagatt ttcatgttga agaattgata 1500aacagctcat actcaaagtc taatcctgta atgcaagaga atgtgatccg tcgagtagac 1560agtcttttag aacggtcggt atttaaagat tttcgagcca tagttacgag ctgtgaaaca 1620cgatttgaga tgaaaaaaat gctcgaccca catttccctg atcttttggt tttatctcat 1680gatgagcttc ctaaagaaat ccctatttcc ttcttaggga tcgtttcaga tgaggtttta 1740gttccttaa 1749<210>470<211>516<212>DNA<213>肺炎衣原体<400>470atgaaaaaat tattattttc tacatttctt cttgttttag gatcaacaag cgcagctcat 60gcaaatttag gctatgttaa tttaaagcga tgtcttgaag aatccgatct aggtaaaaag 120gaaactgaag aattggaagc tatgaaacag cagtttgtaa aaaatgctga gaaaatagaa 180gaagaactca cttctattta taataagttg caagatgaag attacatgga aagcctatcg 240gattctgcct ctgaagagtt gcgaaagaaa ttcgaagatc tttcaggaga gtacaatgcg 300taccagtctc agtactatca atctatcaat caaagtaatg taaaacgcat tcaaaaactc 360attcaagaag taaaaatagc tgcagaatca gtgcggtcca aagaaaaact agaagctatc 420cttaatgaag aagctgtctt agcaatagca cctgggactg ataaaacaac cgaaattatt 480gctattctta acgaatcttt caaaaaacaa aactag 516<210>471<211>1083<212>DNA<213>肺炎衣原体<400>471atgtccgaag caccagtcta cactcttaaa cagttagctg agctactaca agtcgaagtt 60caaggaaata tagaaactcc tatttcaggt gttgaagata ttagtcaggc gcaacctcac 120catattgctt ttttagataa tgagaaatac tctagctttc taaaaaacac caaagctggt 180gctattattt tatctagatc tcaggcaatg caacatgccc acctaaagaa aaactttctt 240attaccaatg aatccccttc tctaacattt caaaagtgca tagagttgtt tattgaaccc 300gtaacatcag ggtttcctgg tattcatcct actgcagtga ttcatcctac tgcacgtatt 360gagaaaaatg taaccataga accttacgtt gtcattagtc aacatgccca tatcggctct 420gacacataca tcggagctgg aagtgtcatt ggagctcaca gcgttctagg tgctaactgt 480ctgattcacc ctaaggtggt gattcgagaa agagtcctca tgggaaaccg tgtagttgtt 540caacctggag ctgttttagg atcctgtggt tttggttata ttacaaatgc ttttggtcat 600cacaaacctt taaagcatct aggctatgtg attgtaggtg atgatgtaga aatcggagcc 660aacactacga tagatcgtgg tcgattcaag aacaccgtga tccatgaagg aactaaaata 720gataaccaag tacaagtagc tcatcacgta gaaattggaa agcatagtat tattgttgcc 780caagcaggca ttgcaggttc tacaaaaatt ggtgaacatg tcatcattgg agggcaaacc 840ggaattactg ggcatatttc tattgcagac catgtgatca tgattgctca aactggagtc 900acaaaatcta tcacctctcc aggcatttat ggaggcgctc cagcacgacc ttatcaagaa 960acacatcggt tgattgctaa aattcggaac cttcctaaaa ctgaagaaag actaagtaag 1020ttagaaaaac aagtaagaga tctatcgact cccagccttg ctgagattcc ttcagagatc 1080taa 1083<210>472<211>1200<212>DNA<213>肺炎衣原体<400>472atggcagcat caggaggcac aggtggttta ggaggcactc agggtgtcaa ccttgcagct 60gtagaagctg cagctgcaaa agcagatgca gcagaagttg tagccagcca agaaggttct 120gagatgaaca tgattcaaca atctcaggac ctgacaaatc ccgcagcagc aacacgcacg 180aaaaaaaagg aagagaagtt tcaaactcta gaatctcgga aaaaaggaga agctggaaag 240gctgagaaaa aatctgaatc tacagaagag aagcctgaca cagatcttgc tgataagtat 300gcttctggga attctgaaat ctctggtcaa gaacttcgcg gcctgcgtga tgcaatagga 360gacgatgctt ctccagaaga cattcttgct cttgtacaag agaaaattaa agacccagct 420ctgcaatcca cagctttgga ctacctggtt caaacgactc caccctccca aggtaaatta 480aaagaagcgc ttatccaagc aaggaatact catacggagc aattcggacg aactgctatt 540ggtgcgaaaa acatcttatt tgcctctcaa gaatatgcag accaactgaa tgtttctcct 600tcagggcttc gctctttgta cttagaagtg actggagaca cacatacctg tgatcagcta 660ctttctatgc ttcaagaccg ctatacctac caagatatgg ctattgtcag ctcctttcta 720atgaaaggaa tggcaacaga attaaaaagg cagggtccct acgtacccag tgcgcaacta 780caagttctca tgacagaaac tcgtaacctg caagcagttc ttacctcgta cgattacttt 840gaaagtcgcg ttcctatttt actcgatagc ttaaaagctg agggaatcca aactccttct 900gatctaaact ttgtgaaggt agctgagtcc taccataaaa tcattaacga taagttccca 960acagcatcta aagtagaacg agaagtccgc aatctcatag gagacgatgt tgattctgtg 1020accggtgtct tgaacttatt cttttctgct ttacgtcaaa cgtcgtcacg ccttttctct 1080tcagcagaca aacgtcagca attaggagct atgattgcta atgctttaga tgctgtaaat 1140ataaacaatg aagattatcc caaagcatca gacttcccta aaccctatcc ttggtcatga 1200<210>473<211>675<212>DNA<213>肺炎衣原体<400>473atgacatcct ggatagaatt acttgataag caaattgaag atcaacatat gttaaagcac 60gaattttatc agcgttggtc tgaaggaaag ttagaaaaac aacaacttca agcttatgcc 120aaagattact atttacatat taaagcattt ccttgttacc tttcagcgct gcatgctcgc 180tgtgatgact tgcagattcg tagacaaatt cttgagaatc tcatggatga agaagctgga 240aatcctaatc acatagattt atggagacag tttgctttat ctcttggagt ttctgaagag 300gagcttgcca atcatgaatt cagtcaggct gctcaagata tggtagcgac atttcgccgc 360ttatgcgaca tgccacaact tgccgtgggt ttaggcgctc tctatactta tgagattcag 420attcctcaag tctgtgtaga gaaaatccgt ggtttgaaag aatattttgg agtttctgct 480cgaggctatg catactttac tgtacatcaa gaagctgata ttaaacatgc cagcgaagag 540aaagaaatgc tacaaacttt ggtaggcaga gagaatcctg atgctgtttt gcaaggatca 600caagaagttt tagatactct atggaacttt ttgagctctt ttattaattc aacggagcct 660tgttcttgta agtag 675<210>474<211>741<212>DNA<213>肺炎衣原体<400>474atgaaaatca ccacagtcaa aacaccaaaa atatatcctt atgatgacct atattctatt 60ctagagtctt cattgcctaa gttaaacgaa cgctctattg ttgtgattac gtctaagata 120gtctctttat gtgaaggtgc tgttgtagaa cttgagaagg tttctaaaga tgaattaata 180aagcaagaag cagatgccta tgtttttgta gagaaatacg gcatatatct aactaagaag 240tgggggatac tcattccttc agcggggatt gacgagtcca atgttgaagg ttattttgtg 300ttgtatccta gggatttttt gctttccgtg aatactctag gggattggtt aaggaatttc 360tatcatctcg agcattgcgg aatcattata tcggatagtc atacgactcc gttgcgtcgg 420ggaactatgg gtttaggctt atgttggaat ggttttttcc ctttatataa ttatgtagga 480aaaccagatt gttttggtcg tgctttgaag atgacttata gcaatttatt agatggttta 540tcggcagctg cggttctttg tatgggagag ggagacgagc agactcccat tgctattata 600gaggaagctc ccaagattac cttccattct tctccaacta cattacaaga tatgagcact 660ttagcaatcg ctgaggatga agatttatat ggtcctctgc tacaatctat ggcatgggaa 720actcccgcac caacctcctg a 741<210>475<211>1062<212>DNA<213>肺炎衣原体<400>475atgaataaaa gacaaaaaga taaattaaaa atctgtgtta ttattagcac gttgatttta 60gtaggaattt ttgcaagagc tcctcgtggt gacactttta agactttttt aaagtctgaa 120gaagctatca tctactcaaa tcaatgcaat gaggacatgc gtaaaattct atgcgatgct 180atagaacacg ctgatgaaga gatcttccta cgtatttata acctctcaga acccaagatc 240caacagagtt taactcgaca agctcaagca aaaaacaaag ttacgatcta ctatcaaaaa 300tttaaaattc cccaaatctt aaagcaagcc agcaatgtaa ctttagtcga gcaacctcca 360gcagggcgta aactgatgca tcaaaaagct ctttccatag ataagaaaga tgcttggcta 420ggatctgcga actacaccaa tctttctcta cgtttagata ataatctcat tctaggaatg 480catagctcgg agctctgtga tctcattatc acaaatacct ctggagactt ttctataaag 540gatcaaacag gaaagtattt tgttcttcct caagatcgta aaattgcaat acaagctgta 600ctcgaaaaaa tccagacagc tcagaaaacc atccaagttg ctatgtttgc tctgacccac 660tcggagatta ttcaagcctt acatcaagca aaacaacgag gaatccatgt agatattatc 720attgatagaa gtcatagcaa acttactttt aagcaattac gacaattaaa tatcaataaa 780gactttgttt ctataaatac cgcaccctgt actcttcacc ataagtttgc agttatagat 840aataaaactc tacttgcagg atctataaat tggtctaaag gaagattctc cttaaatgat 900gaaagcttga tcatactgga aaacctgacc aaacaacaaa atcagaaact tcgaatgatt 960tggaaagatc tagctaagca ttcagaacat cctacagtag acgatgaaga aaaagaaatt 1020atagaaaaaa gtcttccagt agaagagcaa gaagcagcgt ga 1062<210>476<211>561<212>DNA<213>肺炎衣原体<400>476gtggcattaa attttaagat taacaggcaa ataagagctc ctaaagttcg tctcattggt 60tcagccggag aacagttagg aatacttgct atcaaagatg ctttggattt agcccgagag 120gcaggtcttg atttagttga agttgcttca aatagcgagc ctcctgtatg taagatcatg 180gactacggta aataccgtta tggtctgaca aaaaaggaaa aagatagtaa aaaagctcaa 240catcaggtgc gcataaaaga agttaagctt aagcctaaca tagacgaaaa tgatttttcg 300actaagttaa agcaagcgcg tacgttcgtt gaaaaaggaa ataaagtcaa aattacatgc 360atgttccgtg gtagagaatt agcttatcca gaacatggtt ttaaagttgt tcaaaaaatg 420agtcagggtt tagaggatat tggtttcgtt gaagctgaac ccaaactagc aggtcgttcc 480ttgatttgtg ttgtggctcc aggaacagta aaaacaaaga aaaaacagga aaagtctcat 540gcccaagatg aaaaccaata a 561<210>477<211>3135<212>DNA<213>肺炎衣原体<400>477atggtcgaag ttgaagaaaa gcattacacc atcgtcaaac gtaatggaat gtttgtccca 60tttaatcaag atcggatttt ccaggctttg gaggcagctt ttcgagatac gcgtagctta 120gaaactagtt ctccactacc taaagactta gaagaatcta ttgcgcaaat tactcataaa 180gtcgtgaagg aagtcctcgc taaaatttca gaaggtcagg tagtcactgt agagagaatc 240caggatcttg tagaaagtca gctctatatt agcgggttgc aggatgtggc tcgcgattat 300attgtttaca gggaccaacg caaggcagag cgcggtaact cttcgtccat aattgccatc 360atacgtagag acgggggaag cgctaaattt aatcctatga agatctctgc agctctcgaa 420aaagcattca gagcgacgct ccaaattaat gggatgactc ctcctgcaac actatccgaa 480attaatgacc ttacccttag gatcgttgaa gatgtcctaa gccttcatgg tgaagaagct 540attaatctgg aagagatcca agatattgtt gaaaagcaac ttatggttgc cggctattat 600gatgtggcca agaattatat tttatataga gaagctcgtg cacgagcccg tgctaataaa 660gatcaagatg gacaagaaga gtttgtcccc caagaggaaa cgtacgttgt tcaaaaagaa 720gacggcacca cctaccttct gagaaaaaca gatttagaaa agaggttttc ttgggcatgc 780aaacgctttc ctaaaactac agattctcaa ctgcttgcag atatggcatt tatgaatttg 840tattcaggaa tcaaagaaga cgaggtcacc acagcatgca tcatggcggc acgtgccaat 900atcgagagag aacctgatta cgcttttatc gcagcagaac tcctcacgag ttccttgtat 960gaagagacct taggatgcag ctctcaagac cccaatttat cagaaataca taaaaaacat 1020tttaaagaat acatcctcaa tggagaagag tatcgcttga atcctcaatt aaaggattat 1080gatctcgatg ctcttagtga agtcctagac ctctctagag accaacagtt ttcctatatg 1140ggagtccaaa atctctacga tcgctatttt aatctgcatg aaggacgacg tttagagact 1200gcgcagatct tttggatgcg ggtttctatg ggcttagcct taaatgaagg agaacaaaag 1260aatttttggg caatcacttt ctataatctg ttatccacat tccgctatac cccagcaact 1320cctacattgt ttaactccgg aatgcgtcat tcccaactca gttcatgcta tctttccaca 1380gtaaaagatg acctaagtca catttataag gtgatttctg ataatgcttt gctttctaaa 1440tgggcagggg gaattggaaa tgattggaca gatgtccgtg ctacaggagc tgtaattaag 1500ggaaccaatg gaaagagtca aggcgtcatt cccttcatta aggttgccaa tgatactgca 1560attgcagtga atcagggggg caaacgtaaa ggtgctatgt gcgtatattt agaaaactgg 1620cacttggatt acgaagactt tttagaattg cggaagaata caggagatga gcgtcgtaga 1680actcacgata tcaatacagc aagctggatt cctgatctct tctttaagag actagaaaaa 1740aaaggcatgt ggacactctt tagccccgat gatgtcccag gtttacacga agcctatggg 1800ttagagtttg aaaagcttta tgaagaatat gaacgtaagg ttgaatctgg ggaaatccgt 1860ctttataaaa aagtagaagc cgaagtgctg tggcgtaaaa tgttaagcat gctttacgaa 1920acagggcatc cttggattac atttaaagat ccttcgaata ttcgctcaaa ccaagatcat 1980gttggcgtcg tacgctgttc taatctatgt acagagattt tattgaactg ttcggaatca 2040gagactgcag tttgtaattt aggttccata aacttggtag aacatatccg taatgacaag 2100ttagatgaag aaaaattaaa agaaactatc tcaatagcca tccgtatttt ggataacgtt 2160attgacctga acttctaccc tacaccagag gctaaacaag ccaacctaac tcacagagct 2220gtggggttgg gggttatggg attccaggat gttctttacg agttgaacat tagctatgcc 2280tcacaagaag ctgtcgaatt ttctgacgag tgctcggaga tcatcgcata ctacgctatt 2340ctagcctcga gcttactcgc gaaagaacga ggtacatatg cttcttattc aggatctaag 2400tgggatcgtg ggtatctacc cttagatact atcgagcttc tcaaagaaac tcgcggagag 2460cataatgttc ttgtagacac atcaagtaaa aaagattgga ctccagttcg tgatactatc 2520cagaaatacg gaatgagaaa tagccaggtc atggcaattg ctcctacagc aacgatctcg 2580aatatcatag gggtcaccca atctatagag cccatgtata aacatctctt tgtaaagtcc 2640aacctttccg gagagtttac gatccccaac acctacctga ttaaaaaact taaggaatta 2700ggactttggg atgcagaaat gttagatgat ctaaaatatt ttgacggatc tctattggaa 2760attgaaagga tccctaatca cttgaaaaag cttttcctta cggcatttga aatcgaaccc 2820gagtggatta tagagtgtac ctctagaaga cagaaatgga ttgatatggg agtttctcta 2880aatctgtatc ttgctgagcc agatggtaaa aaactctcca atatgtatct cacggcttgg 2940aaaaaaggat taaagactac ctattattta agatctcaag ctgcaacatc agtagagaaa 3000tcatttatag atatcaataa acgcggcatt cagcctcgtt ggatgaaaaa taaatcagcg 3060tccacaagta ttgtggtcga aagaaaaaca acccccgttt gttcaatgga agaaggttgc 3120gaatcttgtc aataa 3135<210>478<211>1041<212>DNA<213>肺炎衣原体<400>478atggaagcag atattttaga tggaaagctc aaacgggttg aggtaagtaa aaaaggattg 60gtgaattgta atcaagtaga tgtcaatcag ctagtcccta tcaagtataa atgggcttgg 120gaacattacc tcaatggatg tgcaaacaac tggcttccta ctgaagttcc tatggcaaga 180gatatcgagt tgtggaaatc agatgaactg tctgaagacg aacgcagggt cattttgtta 240aacctaggat ttttcagtac cgcggaaagc ctagtcggaa ataacatcgt tcttgctatc 300ttcaaacata tcacaaaccc tgaagcaaga cagtatttac tgcgtcaagc ttttgaggaa 360gccgtacata cacatacatt tctctatatt tgcgaatctt taggacttga tgaaggcgaa 420gtattcaatg cctataatga aagagcctca attagggcta aagatgattt tcaaatgaca 480ttaacagtcg atgtccttga tcctaatttt tctgtacagt cttcagaagg ccttgggcag 540ttcattaaaa acttagtagg atactatatc attatggaag gaatcttctt ctatagtggt 600tttgtaatga ttctctcttt ccatagacaa aataaaatga caggaattgg agaacagtac 660caatacatcc tcagagatga aaccatacat ttaaattttg gaatcgatct tatcaatgga 720attaaagaag aaaaccccga agtttggact acggaactac aagaagaaat cgtcgctctt 780attgaaaaag ctgtagagct tgaaattgag tacgctaaag attgcttacc tcgaggaatc 840ttgggattaa gatcttcgat gtttatagat tacgttcgtc atattgcaga tcgtcgttta 900gagagaattg ggttgaagcc tatctatcac tccagaaatc ctttcccttg gatgagcgaa 960accatggatc tgaataaaga aaagaatttc tttgaaaccc gggttaccga ataccaaacc 1020gctggtaatt taagttggta a 1041<210>479<211>984<212>DNA<213>肺炎衣原体<400>479atggatgcga aaatgggata tatatttaaa gtgatgcgtt ggattttctg tttcgtggca 60tgtggtataa cttttggatg taccaattct gggtttcaga atgcaaattc acgtccttgt 120atactatcca tgaatcgcat gattcatgat tgtgttgaaa gagtcgtggg gaataggctt 180gctaccgctg ttttgatcaa aggatcctta gaccctcatg cgtatgagat ggttaaaggg 240gataaggaca agattgctgg aagtgccgta attttttgta acggcctggg tcttgagcat 300acattaagtt tgcggaagca tttagaaaat aatcccaata gtgtcaagtt aggggagcgg 360ttgatagcgc gtggggcctt tgttcctcta gaagaagacg gtatttgcga tcctcatatc 420tggatggatc tttctatttg gaaggaagct gtcatagaaa ttacagaagt tctcattgaa 480aagttccctg aatggtctgc tgaatttaaa gcaaatagtg aggaacttgt ttgtgaaatg 540tctattttag attcttgggc gaaacaatgc ttgagcacaa ttcctgaaaa tttacggtat 600cttgtctcag gtcataatgc gttcagttac tttacacgtc gctatttagc tactcctgaa 660gaagtggctt ccggagcatg gaggtctcgt tgtatttctc ctgagggtct atctccagaa 720gctcaaatca gtgttcgtga tattatggcg gttgtagatt atattaatga gcatgatgtc 780agtgtggttt tccctgagga tactctgaac caagatgcgt tgaaaaaaat tgtttcttct 840ctgaagaaaa gtcatttagt tcgtctagct caaaaaccat tgtatagtga taatgtggac 900gacaattatt ttagcacctt taaacataat gtctgcctta tcacagaaga attaggaggg 960gtggctcttg aatgtcaaag atga 984<210>480<211>444<212>DNA<213>肺炎衣原体<400>480atgcaaaacc aatacgagca attactagaa tccttagcac ccctattaaa tacgacactt 60gctccagata aaaataactc ttgtttaatc cgtttcagcg atacccatgt ccctgtgcaa 120atagaagaag atggaaattc cggagatctt gcagtatcga cactactagg tactcttcct 180gaaaacgtat ttcgcgagcg tattttcaaa gctgctctct ctgtaaatgg ctcgttccaa 240tccagcatca agggaattct aggctacggt gaggtcactc aacagctcta tctttcagat 300atcctgagta tgaactacct aaatggagaa aagttattcg agtatctcaa gctcttttct 360ttgcatgcta agatttggat ggaatcccta agaacaggga atcttcctga ccttcatgtt 420ttgggaatct actacgtcgc gtga 444<210>481<211>1581<212>DNA<213>肺炎衣原体<400>481gtgaatgttt taaaatacac aaaacactca ccctcagcac atgcttggaa acttatagga 60acctctccta aacacgggat ttatctccca ctattttcaa tacacacaaa aaatagctgt 120ggaatcggtg aatttttaga tctcattcct ctgatctctt ggtgccaaaa acagggcttc 180agcgttattc agcttctccc tttaaatgat actggtgaag atacgagtcc ctataacagc 240atctcttccg tagccctgaa tcccctattc ctttccctat cctctcttcc aaatatcgat 300accatccctg aagttgccaa gaaacttcaa gatatgcatg agttatgctc gactccatca 360gtcagctata ctcaagttaa agaaaaaaaa tgggcattct taagagagta ctaccaaaaa 420tgttgcaagt cttccctcga aggaaactca aatttttctg agtttctaga aagcgagcgc 480tattggcttt atccctatgg gacctttcgt gcaatcaaac atcatatgca cggagaacct 540attaataact ggccgaagtc gctcacagat caggagaatt ttccggactt aactaaaaaa 600ttccatgatg aagtcctctt tttttcctat ctacagtttc tctgttacca acagctctgc 660gaagtgaaag cctatgcaga tcaacaccac gtcctgctta aaggagacct ccctattctt 720attagcaagg atagctgtga tgtttggtat ttccgagact acttttcttc atcaaggtct 780gtaggagctc ctcctgacct ctacaattct gaaggacaaa actggcatct gcctatttat 840aatttttcac aacttgccaa agacgactac atttggtgga aagagcgtct gcgatatgct 900caaaacttct attccgtcta tcgcttagat catattatag gatttttccg tttgtggatt 960tgggattctt caggaagagg aaggttcatt ccagacaatc ctaaagacta tataaagcag 1020ggcacggaga tcctttctac tatgctcgga gcctcttcta tgttacctat cggagaagat 1080ttagggatta taccccaaga cgtcaaaacg acattaacac acttaggaat ctgtggaacc 1140cggattccac gatgggaacg caactgggaa agcgacagtg ccttcattcc cctaaaagat 1200tataatccac tttctgtgac cactctctct acccacgact ctgatacgtt tgcccaatgg 1260tggctcaatt cacctaagga agctaagcaa tttgctaaat ttctacatct tccttttcaa 1320aaaaccctga ctacagaaac tcaaatagac atcttaaaac tttctcatga atcagcatct 1380atctttcata tcaacctctt taacgattat ctcgccctct gccctgattt agtatcaaaa 1440aatctacaaa gagaacgcat taatacacct gggacaattt ctaaaaagaa ttggtcgtat 1500cgagttcggc cttccttaga agaactcgct attcataaaa aatttaatgg ttacattgag 1560aagatcctta caggactgta a 1581<210>482<211>1908<212>DNA<213>肺炎衣原体<400>482atgatccctt ttactaaaac aatagggttc cgtttgtggt tggcttgcgc cgttgctatc 60attgcacctc tagggatcaa catcgtatgg ttaaacctag atcaataccg caccatagtc 120tctgctattt ctactgcact gaaagaaaac gctgctttca aagccaatac tctcactcag 180attgtccctt tgaatgtcga tgttctatct ctattttctg atgtcttaga tttagatgct 240ggtattccag agactccgaa cgttctcctt agcaatgaaa tgcagaaagt attccaaggg 300atctataatg aaatctcttt aatcaaggta ttcccaaatg gagataaaat tgttgttgct 360tctagcattc ctgaacactt aggggaaaac tataatcaca aaatagacat ccctaagaac 420actccatttt tagcagccct aaaacaatct cctaaaaatc aggaagtctt ttctgtaatg 480caagctaatg tttttgatgc aaaaactcaa gaactccaag ggatcttata caccacgttc 540agtgctgaga gcttactcaa agatctcctg ataaacaagc aatcctatct cactgtaaaa 600actgcgatcc tttccaaata cggcgttatc ttaaaagctt ctgatcctgc tctccatctc 660catactgtct accctgacat gacgaaagaa aaattctgcc aagtttttct caatgatgat 720ccttgcccta tagactcaga attaggtcct ttaactctct cccctctgga tattggagaa 780aatttctatt cttttaaaat caaagatact gagatttggg gctgtattga aaatgttccc 840agtatagata ttgcagtcct ttcctatgct aaaaaagaag agagctttgc gcctttatgg 900cgcagagctc gcatgtacac tgcctatttc ttttgcattc tcttagggag cctcatagcc 960tttattgtag caagacgatt gtcgttacct atcagaaaac ttgccactgc gatgatagaa 1020tctaggaaaa acaaaaactg cctctatact gacgactcct tagggtttga gatcaacaga 1080cttggccata tttttaatgc tatggtggag aatctccaca aacagcaaca cctcgctaag 1140acgaactttg agatgaaaga aaatgcacag aacgctctac atttaggaga gcaggctcag 1200cagcgacttc ttcctaatac tctccccagc tatcctcata tagaactcgc aaaagcctat 1260atccctgcca ttactgtagg tggtgatttc tttgatgttt ttgttgtagg agagggttcg 1320aaggctcgcc tattcctgat tgttgctgac gcctcaggga aaggtgttaa tgcttgtggg 1380tattcgctat ttctaaaaaa tatgctcaga acattccttt ctcgctcttc gtctcttcaa 1440caggcaatcc aagaaacctc acgcttattt tataacaata caaaaaactc agggatgttt 1500gtcactctat gtgtgtactg ttatcatcaa acttccaaca ccatggaata ttattcttgt 1560ggacatcctc ctgcctgcta cctagatcct gatggcgaga cttcttggct attccatcct 1620ggaatggctt taggcttcct tcccgaagtt gcgaacatca cttcaaagct atttcatcct 1680aagccagggt ctctctttgt cttgtattct gatggtatta cagaagccca taataacaat 1740aacgacatgt ttggagaaga gcgcctacaa gctgcaattc aaggattgac agggaaaagt 1800gctgctgatg ccgtccacag gttgatgtta agtgtaaaaa cctttgtcgg gaactcccat 1860caacatgacg acatcacctt attaatatta aaggtattag aatcatga 1908<210>483<211>945<212>DNA<213>肺炎衣原体<400>483gtgttctcat acataaaaaa ccgaattctt tttaatttgc tttctctatg gattgttttg 60acactcacgt tcctagttat gaaaaccatc ccaggagatc ctttcaatga cgaaggctgc 120aatgttcttt ccgaagaggt cttacaaacc ctaaagtctc gatacggttt agataaacct 180ctctatcaac aatacacaca atacctccac tccatcgcaa aactagattt tgggaactcg 240ttagtttata aagatcgcaa agtaacgaac atcatttcga ctgcctttcc tatatcagca 300atcctaggat tgcaaagtct ttttctctcc ataggagggg ggatcgctct cggcaccata 360gcagcattaa aaaaaaagaa acaaagacgc tatattctag gcgcctctat actccaaatc 420tcgattcctg cttttatatt cgcaacactc ttacaatatg tctttgctgt aaaaattcct 480cttcttccta tcgcctgttg gggaagcttt actcatacta tactcccgac tctcgcactt 540gctgtaactc ccatggcctt catcatacag cttacctact cttcagtatc cgcagcatta 600aacaaagact atgtcctact agcctatgca aaaggactct ccccacttaa agtcgttata 660aaacatattt taccctacgc catattccca accatttctt attccgcatt cctaactact 720acagtgatta caggaacctt tgctatcgaa aatatcttct gtattcctgg attaggtaaa 780tggtttattt gtagtatcaa acaacgagac tacccagtag cccttggctt atccgtattt 840tatggaacct tatttatgct ctcttcttta ctttctgacc tgattcaatc cattatagat 900ccgcaaatcc gttatgcgca cggaaaggaa aaaaaaagaa aataa 945<210>484<211>3723<212>DNA<213>肺炎衣原体<400>484ttgacctgga taccccttca ctgtcattct caatactctg ttcttgatgc aatgagctcc 60atcaaagatt tcgttgcgaa aggtcaggaa tttggaattc ccgctctggc tctaacagac 120catgggaatc tttatggagc tgttgatttc tataaagaat gcactcaaaa agggatccaa 180cccatcattg gttgcgagtg ttatattgct ccaggatcac gtttcgataa gaaaaaagag 240aagcgtagtc gtgcagcaca ccatctcatt ttattatgta aaaatgaaca agggtaccgc 300aacctttgta ttttaacctc cctagcattt actgagggtt tctattactt tcctcggata 360gacaaggatc ttttgagaca gtactctgaa ggcttaatct gtttatctgg ttgtttatct 420agttctgttt cagatgctgc cttaaaatct ccggaagctc tgcttcttga attgcaatgg 480tttcaagacc tattcaaaga tgattatttc acagaagtac aactacacaa gatgtccgaa 540gagagcattg caggctttaa agaggaatgg ttaaagcaag aatattactc tctcattgaa 600aaacagatca aagtcaatac tgcagtgtta gaagcaagta agcgcttagg cattcctact 660gtagctacga atgacatcca ttacatcaat gcaaacgatt ggcaagctca tgaaatcctg 720ttgaatgtcc aatctgggga gactgtgcgg attgcgaaac agaatactca tatccccaat 780cctaaacgaa aggtctatcg cagtcgcgag tactatttta aatcccctgc gcaaatggca 840gagttattta aagatattcc tgaggtcatt tccaacacat tagaagttgc caaacggtgt 900gattttactt ttgatttttc caagaaacac taccctatct atgtccctga atctttaaaa 960accttaaaca gctacacgga ggaagaccgt tatcaagctt ctgcagtctt cttaaaacag 1020ctagctgaag aagctttgcc taagaaatac tcttctgaag ttcttgctca tattgctaag 1080aaatttccac atcgggaccc tatcgatatt gtcaaagaaa ggatggacat ggagatggcc 1140atcatcattc ctaaaggaat gtgtgactat cttttgattg tttgggacat tattcattgg 1200gccaaagcaa atggcattcc tgtaggccct ggaagaggtt caggagctgg atccgtatta 1260ctatttttgt tagggatcac agaaatcgag cccatacgat ttgatttatt ctttgagaga 1320tttatcaatc ctgagcgttt gtcttaccca gatattgaca tcgatatttg catggcagga 1380cgtgaacgtg tcattaatta tgcaattgag cgtcatggca aagataatgt agctcaaatc 1440attacttttg gaactatgaa agccaaaatg gctgtcaaag atgtgggaag aactttagac 1500atggccttat ctaaagtgaa ccacattgcg aaacatattc cagatttaaa tactacgttg 1560tctaaagctt tagaaacaga tcctgaccta catcagctct atattaacga tgccgaatct 1620gcacaagtga ttgatatggc gctttgctta gaaggctcca tacggaatac aggggttcat 1680gctgctggtg tgattatctg tggagaccag ctgaccaatc acattccgat ttgtatttct 1740aaagactcca caatgattac aacacaatac tctatgaaac ccgtggagag tgttggaatg 1800cttaaagtcg acttattagg gctcaagact ttaaccagta tcaatattgc aatgtctgca 1860attgaaaaga aaacaggaca atcgctagct atggcgacac tgcctttgga tgatgccacc 1920acattttctc ttttacatca gggaaagact atggggatat ttcaaatgga atccaagggg 1980atgcaagaat tagcaaaaaa cctacgccct gacctctttg aggaaatcat tgctatgggt 2040gctttatacc gcccaggccc tatggatatg attccttctt ttattaaccg caagcatggc 2100aaagaaatta tagaatacga ccatcccctt atggaatcca ttcttaagga aacctatgga 2160attatggtct accaagagca agtcatgcag attgctggtg cattagctag ttattctctt 2220ggagaaggtg atgtattacg acgtgccatg gggaagaaag acttccaaca gatggagcag 2280gagcgcgaaa agttctgtaa acgcgcctgc aataacggca tagatcctga gttagcgact 2340gtcatctttg ataagatgga aaaatttgct gcctacggct ttaacaaatc tcatgctgct 2400gcctatggct tgattactta tacaacggcg tatctcaaag caaattatcc taaagagtgg 2460cttgcggcct tacttacctg tgattctgac gatattgaga agataggaaa actgattcga 2520gaagctcaga gtatgggcat tccgattctt cctcctcata tcaatgtctc tagcaatcac 2580tttgtagcta ctgatgaagg catacgcttt gcgatgggag ctattaaagg gattgggcgt 2640ggtttaattg agagcattgt agaagagaga gatcatcatg gtccttatga gagcatccgc 2700gactttatcc agaggtctga tttaaaaaaa gtttcgaaaa aaagtataga aagtttaatc 2760gatgcgggtt gttttgattg ctttgattct aaccgagatt tgctgttagc ctctgtagag 2820cccctctatg aagctattgc caaagacaag aaagaggctg catctggtgt gatgacgttc 2880tttactttag gagctatgga tcgaaaaaat gaagtcccca tttgtcttcc taaagacatt 2940ccgactcgct ctaagaaaga acttttaaaa aaagaaaaag agctcttagg gatttacctt 3000acagagcacc ctatggatac cgtgcgagat catctttctc gtctttctgt agttcttgct 3060ggagaatttg aaaatctccc gcatggttct gtagtccgca ccgtgtttat tattgataaa 3120gtaacgacta aaatttcatc aaaagcgcaa aagaagtttg ctgtccttcg tgttagtgat 3180ggcatcgatt cttatgaact gccgatctgg ccagatatgt atgaagaaca acaagaactt 3240ctagaagaag atcgtcttat ctatgctatt cttgttttag ataagcgcag tgattctcta 3300cgtatttctt gtcgctggat gaaagatctt tctattgtta atgaaaacat catttatgag 3360tgtgatcaag cttttgatag aataaaaaat caggtgcaaa aaatgtcatt tacaatgtca 3420acctctggca aagaaactaa agctaaaggg aataagccta atgagaatgg gcatacacaa 3480gctttagctc ctgtgactct atctttagat ctcaatgaac tccgtcatag tcatctatgt 3540atcttaaaga agattgtgca aaagcaccct ggctcacgga cattagtttt agtttttact 3600caagataacg aaagagttgc ctcgatgtct cctgacgacg cgtatttcgt ttgtgaagat 3660attgaagaac tccgtcaaga acttgtgact gcagaccttc ctgtgcgtgt aattactgtt 3720tga 3723<210>485<211>1731<212>DNA<213>肺炎衣原体<400>485atgacagatt ttcctactca cttcaaagga cccaaactta accccattaa agtaaatcca 60aacttttttg agaggaatcc taaagtcgca agggtactgc aaattacagc cgtagtctta 120ggaatcattg ccctcttatc cggtatagta ctcattatag gcacccctct cggagctcct 180ataagtatga tcctcggcgg atgtctttta gcttctggag gcgccttatt tgttggtggt 240acgattgcta cgatattgca agctagaaat agttataaga aggccgtgaa ccaaaagaaa 300ctctcagagc ctttgatgga acgccccgaa ttgaaagcct tagattattc cctagatctg 360aaagaggtat gggacctaca tcattctgtt gtcaaacatc ttaaaaaatt agacctgaat 420ctttccaaaa cccaaaggga agttctaaat caaatcaaaa ttgatgatga gggaccctcc 480ctaggggaat gcgccgctat gatttcagaa aactacgacg catgcttaaa gatgctcgcg 540tatcgtgagg agctcctgaa agaacaaacc caataccaag agacacgatt caatcagaac 600ctcactcata gaaataaagt tttgctctcc atcctctcaa ggatcacgga caatatttct 660aaagcgggcg gggtcttttc tttgaaattt tccacgctaa gctcgcggat gtcacgaatt 720cataccacca ccactgtgat tctggcttta agtgccgttg tttctgtcat ggtcgtagca 780gctctaattc caggtggcat tttagcacta cctatacttt tggctgttgc tatttctgca 840ggagtgattg tcaccggact ttcctatcta gttcgtcaga ttttaagtaa caccaagcgt 900aatcgtcagg atttttataa agattttgta aaaaatgtag atatagagct tcttaaccaa 960acggtaactt tacagcgatt cctctttgaa atgctcaaag gtgttctgaa agaagaagaa 1020gaagtctcct tagaaggtca agattggtat acacaataca taaccaatgc acccatagaa 1080aaaagattga tcgaagagat cagagttacc tacaaagaga tcgatgctca gaccaaaaaa 1140atgaagacag acttggagtt cttagaaaat gaggtgcgtt ccgggagact gtctgtagcg 1200tccccgtcgg aagatccaag tgaaactcct atttttactc aaggtaagga gtttgcaaag 1260ttacgtcgcc aaacctctca gaatatatcc acgatttatg gtccggacaa tgaaaatatt 1320gatcccgaat tttccttacc ctggatgcct aaaaaagaag aagaaataga ccatagctta 1380gaacctgtta caaagttgga acccggttca agagaagagt tgttgttggt agagggggtc 1440aacccaacct taagagaact caatatgaga attgcacttc tacaacaaca actatcaagt 1500gtccgaaaat ggagacaccc tcgaggggaa cattacggga atgttatcta ttcagataca 1560gaactcgatc gtattcagat gctagaaggc gcattttata atcacctcag ggaagctcaa 1620gaggaaatca cccagtctct cggagacctt gttgacattc aaaaccgtat tttagggatc 1680atagttgaag gggactcaga ttcaagaaca gaagaagagc ctcaggaata g 1731<210>486<211>4224<212>DNA<213>肺炎衣原体<400>486atgaaatatt ctttaccttg gctacttacc tcttcggctt tagttttctc cctacatcca 60ctaatggctg ctaacacgga tctctcatca tccgataact atgaaaatgg tagtagtggt 120agcgcagcat tcactgccaa ggaaacttcg gatgcttcag gaactaccta cactctcact 180agcgatgttt ctattacgaa tgtatctgca attactcctg cagataaaag ctgttttaca 240aacacaggag gagcattgag ttttgttgga gctgatcact cattggttct gcaaaccata 300gcgcttacgc atgatggtgc tgcaattaac aataccaaca cagctctttc tttctcagga 360ttctcgtcac tcttaatcga ctcagctcca gcaacaggaa cttcgggcgg caagggtgct 420atttgtgtga caaatacaga gggaggtact gcgactttta ctgacaatgc cagtgtcacc 480ctccaaaaaa atacttcaga aaaagatgga gctgcagttt ctgcctacag catcgatctt 540gctaagacta cgacagcagc tctcttagat caaaatacta gcacaaaaaa tggcggggcc 600ctctgtagta cagcaaacac tacagtccaa ggaaactcag gaacggtgac cttctcctca 660aatactgcta cagataaagg tggggggatc tactcaaaag aaaaggatag cacgctagat 720gccaatacag gagtcgttac cttcaaatct aatactgcaa agacgggggg tgcttggagc 780tctgatgaca atcttgctct taccggcaac actcaagtac tttttcagga aaataaaaca 840accggctcag cagcacaggc aaataacccg gaaggttgtg gtggggcaat ctgttgttat 900cttgctacag caacagacaa aactggatta gccatttctc agaatcaaga aatgagcttc 960actagtaata caacaactgc gaatggtgga gcgatctacg ctactaaatg tactctggat 1020ggaaacacaa ctcttacctt cgatcagaat actgcgacag caggatgtgg cggagctatc 1080tatacagaaa ctgaagattt ttctcttaag ggaagtacgg gaaccgtgac cttcagcaca 1140aatacagcaa agacaggcgg cgccttatat tctaaaggaa acagctcgct gactggaaat 1200accaacctgc tcttttcagg gaacaaagct acgggcccga gtaattcttc agcaaatcaa 1260gagggttgcg gtggggcaat cctagccttt attgattcag gatccgtaag cgataaaaca 1320ggactatcga ttgcaaacaa ccaagaagtc agcctcacta gtaatgctgc aacagtaagt 1380ggtggtgcga tctatgctac caaatgtact ctaactggaa acggctccct gacctttgac 1440ggcaatactg ctggaacttc aggaggggcg atctatacag aaactgaaga ttttactctt 1500acaggaagta caggaaccgt gaccttcagc acaaatacag caaagacagg cggcgcctta 1560tattctaaag gcaacaactc tctgtctggt aataccaacc tgctcttttc agggaacaaa 1620gctacgggcc cgagtaattc ttcagcaaat caagagggtt gcggtggggc aatcctatcg 1680tttcttgagt cagcatctgt aagtactaaa aaaggactct ggattgaaga taacgaaaac 1740gtgagtctct ctggtaatac tgcaacagta agtggcggtg cgatctatgc gaccaagtgt 1800gctctgcatg gaaacacgac tcttaccttt gatggcaata ctgccgaaac tgcaggagga 1860gcgatctata cagaaaccga agattttact cttacgggaa gtacgggaac cgtgaccttc 1920agcacaaata cagcaaagac agcaggggct ctacatacta aaggaaatac ttcctttacc 1980aaaaataagg ctcttgtatt ttctggaaat tcagcaacag caacagcaac aacaactaca 2040gatcaagaag gttgtggtgg agcgatcctc tgtaatatct cagagtctga catagctaca 2100aaaagcttaa ctcttactga aaatgagagt ttaagtttca ttaacaatac ggcaaaaaga 2160agtggtggtg gtatttatgc tcctaagtgt gtaatctcag gcagtgaatc cataaacttt 2220gatggcaata ctgctgaaac ttcgggagga gcgatttatt cgaaaaacct ttcgattaca 2280gctaacggtc ctgtctcctt taccaataat tctggaggca agggaggcgc catttatata 2340gccgatagcg gagaactttc cttagaggct attgatgggg atattacttt ctcagggaac 2400cgagcgactg agggaacttc aactcccaac tcgatccatt taggtgcagg ggctaagatc 2460actaagcttg cagcagctcc tggtcatacg atttattttt atgatcctat tacgatggaa 2520gctcctgcat ctggaggaac aatagaggag ttagtcatca atcctgttgt caaagctatt 2580gttcctcctc cccaaccaaa aaatggtcct atagcttcag tgcctgtagt ccctgtagca 2640cctgcaaacc caaacacggg aactatagta ttttcttctg gaaaactccc cagtcaagat 2700gcctcgattc ctgcaaatac taccaccata ctgaaccaga agatcaactt agcaggagga 2760aatgtcgttt taaaagaagg agccacccta caagtatatt ccttcacaca gcagcctgat 2820tctacagtat tcatggatgc aggaacgacc ttagagacca cgacaactaa caatacagat 2880ggcagcatcg atctaaagaa tctctctgta aatctggatg ctttagatgg caagcgtatg 2940ataacgattg ccgtaaacag cacaagtggg ggattaaaaa tctcagggga tctgaaattc 3000cataacaatg aaggaagttt ctatgacaat cctgggttga aagcaaactt aaatcttcct 3060ttcttagatc tttcttctac ttcaggaact gtaaatttag acgacttcaa tccgattcct 3120tctagcatgg ctgctccgga ttatgggtat caagggagtt ggactctggt tcctaaagta 3180ggagctggag ggaaggtgac tttggtcgcg gaatggcaag cgttaggata cactcctaaa 3240ccagagcttc gtgcgacttt agttcctaat agcctttgga atgcttatgt aaacatccat 3300tctatacagc aggagatcgc cactgcgatg tcggacgctc cctcacatcc agggatttgg 3360attggaggta ttggcaacgc cttccatcaa gacaagcaaa aggaaaatgc aggattccgt 3420ttgatttcca gaggttatat tgttggtggc agcatgacca cccctcaaga atataccttt 3480gctgttgcat tcagccaact ctttggcaaa tctaaggatt acgtagtctc ggatattaaa 3540tctcaagtct atgcaggatc tctctgtgct cagagctctt atgtcattcc cctgcatagc 3600tcattacgtc gccacgtcct ctctaaggtc cttccagagc tcccaggaga aactcccctt 3660gttctccatg gtcaagtttc ctatggaaga aaccaccata atatgacgac aaagcttgcg 3720aacaacacac aagggaaatc agactgggac agccatagct tcgctgttga agtcggtggt 3780tctcttcctg tagatctaaa ctacagatac cttaccagct actctcccta tgtgaaactc 3840caagttgtga gtgtaaatca aaaaggattc caagaggttg ctgctgatcc acgtatcttt 3900gacgctagcc atctggtcaa cgtgtctatc cctatgggac tcaccttcaa acacgaatca 3960gcaaagcccc ccagtgcttt gcttcttact ttaggttacg ctgtagatgc ttaccgggat 4020caccctcact gcctgacctc cttaacaaat ggcacctcgt ggtctacgtt tgctacaaac 4080ttatcacgac aagctttctt tgctgaggct tctggacatc tgaagttact tcatggtctt 4140gactgcttcg cttctggaag ttgtgaactg cgcagctcct caagaagcta taatgcaaac 4200tgtggaactc gttattcttt ctaa 4224<210>487<211>804<212>DNA<213>肺炎衣原体<400>487atgggcaatt caggtttcta tttacaagat actcaaaaca ctattttcgc agataacatt 60cgtcttggtc aaatgaccac agttcttaaa aaagacgagg ttattatagg cacagataca 120actccaacag taacaaaatt tagtggcgat aagggaattg taattactac agactcaacc 180ataacaccat ctagcactac tttttctttg gatatggaag ctgtaatcaa agaagtaaca 240gataaaatct taactcaaat tgaagatgag ttagtcaaag acattataaa aaacataact 300caaagtctaa tagaagaagt aattaagaaa atacacattg atccttcttt ctcatattct 360agagcattta aagatgttaa tataactaat aaaattcagt gcaatggtct atttacaaaa 420gaaaatatag ggaatttaga cggaggaaca gaaatagctt cgtcttcagt aacacctgat 480aatgctaata gtatgttctt aatttgtgcg gatattatag ccacacgcat ggaaggaaca 540gtggccttgg cgttagttaa agaaggagat ttatctcctt gctctattag ttatggatac 600tccgctggat atccgaatat aatttcacta agagcaaccg tcggaaacaa aacaactgct 660ccagttaaat tctctttgag agcaggaggg atggatagtg gtgttgtgtg ggtaaatgct 720atgccaaatg gagaaaaaat tttaggagtt gacgcagttt cgaagattac tatcttagaa 780gtaaaaccac aaacaaatgg ttaa 804<210>488<211>306<212>DNA<213>肺炎衣原体<400>488atgaataaca gacaaaacac taatgacttt atcagaattg tgaaggatgt tgaaaaggcg 60tttccagaac tagatatcaa agtaaaaata gataaagaaa aagttacttt tttgacttct 120ccaacagagc tttatcacaa aagtatatct gtcatactca atttactaaa cagcattgaa 180tcatctctag accttttccc agactctcca gtagttgaag aattagaaaa aaataatctt 240aagctcaaaa aagctctgat catgctaatt ctatcaagaa aagacatgtt ctcaaaaaca 300gaataa 306<210>489<211>806<212>DNA<213>肺炎衣原体<400>489gtgaaaacaa tagcattttg ctcatttaaa ggagggactg gtaaaactac cttgtctctc 60aatgttggtt gtaatttagc ccaatatagc aacaaaaagg ttttgcttgt ggatttagat 120ccacaagcaa accttactac aggtcttggt gtacaatctt gttatgaatc taatttgaac 180gacattttta gaagttcagg aaacgtaagg gatatcattc aagatacgaa gatagaaaac 240ttacacatag taccttctag tattctcata gaggagtttc gagaatttaa tagaaatagt 300gtactggata caagtcattt gcgttcatct ttacaactta ttgaatccaa ttatgatctg 360tgtattttag acactccacc aagtctgggg acgctcaccg aagaagcctt tattgcatca 420gatcatttga ttgtttgtct tactcctgaa ccattttcca tattaggatt acagaaaatc 480aaagagtttt gttcagtgtt acctaaaaag aaagacttat cagtgttagg aatagttttt 540tctttttggg acggaaggaa ttcaacaaat tcaacctact tgaacattat agaatctatc 600tacgaaggga aagtgttatc tagtaaagta cgaagagaca taacattaag cagatctctt 660ttaaaagaaa catccatagc taacgcatac cctaattcta gagcaagtca tgacatactg 720cgtctaacaa aggagataga agataaacta ttcaataaag aaatgtctgc ccaggaagtg 780ttgtgagtaa gttagtcaaa gaagca 806<210>490<211>293<212>PRT<213>肺炎衣原体<400>490Met Ser Lys His Thr Ser Glu Ser Arg Ile Ala Gln Asp Met Leu Glu 1 5 10 15Arg Tyr Ser Gly Ser Ser Val Lys Gln Phe Cys Pro Tyr Leu Leu Leu

20 25 30Thr Asn Phe Ser Tyr Tyr Ile Gln Thr Phe Ala Lys Leu His Gly Val

35 40 45Pro Val Phe Glu Gly Ser Met Phe Ser Ala Ala His Ala Pro His Leu

50 55 60Lys Thr Ser Ile Leu Asp Phe Lys Leu Gly Ser Pro Gly Ala Ala Leu65 70 75 80Thr Ile Asp Leu Cys Ser Phe Leu Pro Asp Leu Lys Ala Ala Leu Met

85 90 95Leu Gly Met Cys Gly Gly Leu Arg Ser His Tyr Gln Val Gly Asp Tyr

100 105 110Phe Val Pro Val Ala Ser Ile Arg Gly Glu Gly Thr Ser Asp Ala Tyr

115 120 125Phe Pro Pro Glu Val Pro Ala Leu Ala Asn Phe Val Val Gln Lys Ala

130 135 140Thr Thr Glu Val Leu Glu Asp Lys Lys Ala Asn Tyr His Ile Gly Ile145 150 155 160Thr His Thr Thr Asn Ile Arg Phe Trp Glu Phe Asn Lys Lys Phe Arg

165 170 175Lys Lys Leu Tyr Glu Thr Lys Ala Gln Ser Ala Glu Met Glu Cys Ala

180 185 190Thr Leu Phe Ala Ala Gly Tyr Arg Arg Asn Leu Pro Ile Gly Ala Leu

195 200 205Leu Leu Ile Ser Asp Leu Pro Leu Arg Lys Glu Gly Ile Lys Thr Lys

210 215 220Ser Ser Gly Asn Phe Ile Phe Asn Thr Tyr Thr Glu Asp His Ile Leu225 230 235 240Thr Gly Gln Glu Val Ile Glu Asn Leu Glu Lys Val Met Leu Lys Arg

245 250 255Ala Ala Ser Asp His Lys Lys Asp Gln Gln Tyr Arg Gly Leu Pro His

260 265 270Met Glu Val Gly Glu Ala Asp Asp Thr Met Ala Ser Gly Ser Glu Thr

275 280 285Ser Asp Ser Asp Tyr

290<210>491<211>394<212>PRT<213>肺炎衣原体<400>491Met Ser Lys Glu Thr Phe Gln Arg Asn Lys Pro His Ile Asn Ile Gly1 5 10 15Thr Ile Gly His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile

20 25 30Thr Arg Ala Leu Ser Gly Asp Gly Leu Ala Ser Phe Arg Asp Tyr Ser

35 40 45Ser Ile Asp Asn Thr Pro Glu Glu Lys Ala Arg Gly Ile Thr Ile Asn

50 55 60Ala Ser His Val Glu Tyr Glu Thr Pro Asn Arg His Tyr Ala His Val65 70 75 80Asp Cys Pro Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Ala

85 90 95Ala Gln Met Asp Gly Ala Ile Leu Val Val Ser Ala Thr Asp Gly Ala

100 105 110Met Pro Gln Thr Lys Glu His Ile Leu Leu Ala Arg Gln Val Gly Val

115 120 125Pro Tyr Ile Val Val Phe Leu Asn Lys Val Asp Met Ile Ser Gln Glu

130 135 140Asp Ala Glu Leu Ile Asp Leu Val Glu Met Glu Leu Ser Glu Leu Leu145 150 155 160Glu Glu Lys Gly Tyr Lys Gly Cys Pro Ile Ile Arg Gly Ser Ala Leu

165 170 175Lys Ala Leu Glu Gly Asp Ala Asn Tyr Ile Glu Lys Val Arg Glu Leu

180 185 190Met Gln Ala Val Asp Asp Asn Ile Pro Thr Pro Glu Arg Glu Ile Asp

195 200 205Lys Pro Phe Leu Met Pro Ile Glu Asp Val Phe Ser Ile Ser Gly Arg

210 215 220Gly Thr Val Val Thr Gly Arg Ile Glu Arg Gly Ile Val Lys Val Ser225 230 235 240Asp Lys Val Gln Leu Val Gly Leu Gly Glu Thr Lys Glu Thr Ile Val

245 250 255Thr Gly Val Glu Met Phe Arg Lys Glu Leu Pro Glu Gly Arg Ala Gly

260 265 270Glu Asn Val Gly Leu Leu Leu Arg Gly Ile Gly Lys Asn Asp Val Glu

275 280 285Arg Gly Met Val Val Cys Gln Pro Asn Ser Val Lys Pro His Thr Lys

290 295 300Phe Lys Ser Ala Val Tyr Val Leu Gln Lys Glu Glu Gly Gly Arg His305 310 315 320Lys Pro Phe Phe Ser Gly Tyr Arg Pro Gln Phe Phe Phe Arg Thr Thr

325 330 335Asp Val Thr Gly Val Val Thr Leu Pro Glu Gly Thr Glu Met Val Met

340 345 350Pro Gly Asp Asn Val Glu Leu Asp Val Glu Leu Ile Gly Thr Val Ala

355 360 365Leu Glu Glu Gly Met Arg Phe Ala Ile Arg Glu Gly Gly Arg Thr Ile

370 375 380Gly Ala Gly Thr Ile Ser Lys Ile Asn Ala385 390<210>492<211>560<212>PRT<213>肺炎衣原体<220><221>VARIANT<222>553，554，555，556，558，559，560<223>Xaa＝任何氨基酸<400>492Met Pro Gln Lys Val Leu Ile Thr Ser Ala Leu Pro Tyr Ala Asn Gly1 5 10 15Pro Leu His Phe Gly His Ile Ala Gly Val Tyr Leu Pro Ala Asp Val

20 25 30Tyr Ala Arg Phe Arg Arg Leu Leu Gly Asp Asp Val Leu Tyr Ile Cys

35 40 45Gly Ser Asp Glu Phe Gly Ile Ala Ile Thr Leu Asn Ala Asp Arg Glu

50 55 60Gly Leu Gly Tyr Gln Glu Tyr Val Asp Met Tyr His Lys Leu His Lys65 70 75 80Asp Thr Phe Glu Lys Leu Gly Phe Ala Leu Asp Phe Phe Ser Arg Thr

85 90 95Thr Asn Pro Phe His Ala Glu Leu Val Gln Asp Phe Tyr Ser Gln Leu

100 105 110Lys Ala Ser Gly Leu Ile Glu Asn Arg Ile Ser Glu Gln Leu Tyr Ser

115 120 125Glu Gln Glu Gln Arg Phe Leu Ala Asp Arg Tyr Val Glu Gly Thr Cys

130 135 140Pro Arg Cys Gly Phe Asp His Ala Arg Gly Asp Glu Cys Gln Ser Cys145 150 155 160Gly Ala Asp Tyr Glu Ala Ile Asp Leu Ile Gly Pro Lys Ser Lys Ile

165 170 175Ser Gly Val Glu Leu Val Lys Lys Glu Thr Glu His Ser Tyr Phe Leu

180 185 190Leu Asp Arg Met Lys Asp Ala Leu Leu Ser Phe Ile Gln Gly Cys Tyr

195 200 205Leu Pro Asp His Val Arg Lys Phe Val Val Asp Tyr Ile Glu His Val

210 215 220Arg Ser Arg Ala Ile Thr Arg Asp Leu Ser Trp Gly Ile Pro Val Pro225 230 235 240Asp Phe Pro Gly Lys Val Phe Tyr Val Trp Phe Asp Ala Pro Ile Gly

245 250 255Tyr Ile Ser Gly Thr Met Glu Trp Ala Ala Ser Gln Gly Asn Pro Asp

260 265 270Glu Trp Lys Arg Phe Trp Leu Glu Asp Gly Val Glu Tyr Val Gln Phe

275 280 285Ile Gly Lys Asp Asn Leu Pro Phe His Ser Val Val Phe Pro Ala Met

290 295 300Glu Leu Gly Gln Lys Leu Asp Tyr Lys Lys Val Asp Ala Leu Val Val305 310 315 320Ser Glu Phe Tyr Leu Leu Glu Gly Arg Gln Phe Ser Lys Ser Glu Gly

325 330 335Asn Tyr Val Asp Met Asp Lys Phe Leu Ser Ser Tyr Ser Leu Asp Lys

340 345 350Leu Arg Tyr Val Leu Ala Ala Thr Ala Pro Glu Thr Ser Asp Ser Glu

355 360 365Phe Thr Phe Leu Asp Phe Lys Thr Arg Cys Asn Ser Glu Leu Val Gly

370 375 380Lys Phe Gly Asn Phe Ile Asn Arg Val Leu Ala Phe Ala Glu Lys Asn385 390 395 400His Tyr Asp Lys Leu Ser Tyr His Ser Val Val Leu Glu Asp Ser Asp

405 410 415Arg Ala Phe Leu Glu Glu Ala Arg Gln Leu Val Arg Asp Ala Glu Lys

420 425 430Cys Tyr Arg Glu Tyr Ser Leu Arg Lys Ala Thr Ser Val Ile Met Ser

435 440 445Leu Ala Ala Leu Gly Asn Val Tyr Phe Asn Gln Gln Ala Pro Trp Lys

450 455 460Leu Leu Lys Glu Gly Thr Arg Glu Arg Val Glu Ala Ile Leu Phe Cys465 470 475 480Ala Cys Tyr Cys Gln Lys Leu Leu Ala Leu Ile Ser Tyr Pro Ile Ile

485 490 495Pro Glu Ser Ala Val Ala Ile Trp Glu Met Ile Ser Pro Lys Ser Leu

500 505 510Glu Asn Cys Asn Leu Asp Thr Met Tyr Ala Arg Asp Leu Trp Lys Glu

515 520 525Glu Ile Leu Asp Val Ile Asn Glu Glu Phe His Leu Lys Ser Pro Arg

530 535 540Leu Leu Phe Thr Thr Val Glu Thr Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa545 550 555 560<210>493<211>97<212>PRT<213>肺炎衣原体<400>493Met Ile Lys Lys Asp Arg Phe Thr Asn Glu Lys Leu Asn Lys Leu Phe1 5 10 15Asp Ser Pro Phe Ser Leu Val Asn Tyr Ala Ile Lys Gln Ala Lys Ile

20 25 30Lys Ile Ala Lys Gly Asp Val Arg Ser Ser Asn Val Ala Ile Glu Thr

35 40 45Leu Val Leu Leu Asp Arg Glu Gly Ile Gln Pro Glu Phe Thr Glu Glu

50 55 60Ile Val Val Thr Ala Ser Pro Thr Val Glu Arg Lys Arg Ser Glu His65 70 75 80Thr Asn Ser Arg Lys Lys Asp Pro Ser Ala Tyr Thr Trp Ser Asp Val

85 90 95Lys<210>494<211>205<212>PRT<213>肺炎衣原体<400>494Met Asn Lys Ile Leu Val Asp Ser Pro Phe Ser Pro Asp His Gln Lys1 5 10 15Cys Cys Pro Lys Leu Phe Thr Ile Ser Ala Pro Ala Gly Val Gly Lys

20 25 30Thr Thr Leu Val Arg Met Leu Glu Gln Glu Phe Ser Ser Ala Phe Ala

35 40 45Glu Thr Ile Ser Val Thr Thr Arg Lys Pro Arg Glu Gly Glu Val Pro

50 55 60Gly Lys Asp Tyr His Phe Val Ser His Glu Glu Phe Gln Arg Leu Leu65 70 75 80Asp Arg Gln Ala Leu Leu Glu Trp Val Phe Leu Phe Gly Glu Cys Tyr

85 90 95Gly Thr Ser Met Leu Glu Ile Glu Arg Ile Trp Ser Leu Gly Lys His

100 105 110Ala Val Ala Val Ile Asp Ile Gln Gly Ala Leu Phe Ile Arg Ser Arg

115 120 125Met Pro Ser Val Ser Ile Phe Ile Ala Pro Pro Ser Gln Glu Glu Leu

130 135 140Glu Arg Arg Leu Ala Ser Arg Gly Ser Glu Glu Gly Ser Gln Arg Lysl45 150 155 160Glu Arg Leu Glu His Ser Leu Ile Glu Leu Ala Ala Ala Asn Gln Phe

165 170 175Asp Tyr Val Ile Ile Asn Asp Asp Leu Asn Gln Ala Tyr Arg Val Leu

180 185 190Lys Ser Ile Phe Ile Ala Glu Glu His Arg Asn Ile Leu

195 200 205<210>495<211>602<212>PRT<213>肺炎衣原体<400>495Met Lys Glu Tyr Lys Ile Glu Asn Ile Arg Asn Phe Ser Ile Ile Ala1 5 10 15His Ile Asp His Gly Lys Ser Thr Ile Ala Asp Arg Leu Leu Glu Ser

20 25 30Thr Ser Thr Val Glu Glu Arg Glu Met Arg Glu Gln Leu Leu Asp Ser

35 40 45Met Asp Leu Glu Arg Glu Arg Gly Ile Thr Ile Lys Ala His Pro Val

50 55 60Thr Met Thr Tyr Leu Tyr Glu Gly Glu Val Tyr Gln Leu Asn Leu Ile65 70 75 80Asp Thr Pro Gly His Val Asp Phe Ser Tyr Glu Val Ser Arg Ser Leu

85 90 95Ser Ala Cys Glu Gly Ala Leu Leu Ile Val Asp Ala Ala Gln Gly Val

100 105 110Gln Ala Gln Ser Leu Ala Asn Val Tyr Leu Ala Leu Glu Arg Asp Leu

115 120 125Glu Ile Ile Pro Val Leu Asn Lys Ile Asp Leu Pro Ala Ala Asp Pro

130 135 140Val Arg Ile Ala Gln Gln Ile Glu Asp Tyr Ile Gly Leu Asp Thr Thr145 150 155 160Asn Ile Ile Ala Cys Ser Ala Lys Thr Gly Gln Gly Ile Pro Ala Ile

165 170 175Leu Lys Ala Ile Ile Asp Leu Val Pro Pro Pro Lys Ala Pro Ala Glu

180 185 190Thr Glu Leu Lys Ala Leu Val Phe Asp Ser His Tyr Asp Pro Tyr Val

195 200 205Gly Ile Met Val Tyr Val Arg Ile Ile Ser Gly Glu Leu Lys Lys Gly

210 215 220Asp Arg Ile Thr Phe Met Ala Ala Lys Gly Ser Ser Phe Glu Val Leu225 230 235 240Gly Ile Gly Ala Phe Leu Pro Lys Ala Thr Phe Ile Glu Gly Ser Leu

245 250 255Arg Pro Gly Gln Val Gly Phe Phe Ile Ala Asn Leu Lys Lys Val Lys

260 265 270Asp Val Lys Ile Gly Asp Thr Val Thr Lys Thr Lys His Pro Ala Lys

275 280 285Thr Pro Leu Glu Gly Phe Lys Glu Ile Asn Pro Val Val Phe Ala Gly

290 295 300Ile Tyr Pro Ile Asp Ser Ser Asp Phe Asp Thr Leu Lys Asp Ala Leu305 310 315 320Gly Arg Leu Gln Leu Asn Asp Ser Ala Leu Thr Ile Glu Gln Glu Ser

325 330 335Ser His Ser Leu Gly Phe Gly Phe Arg Cys Gly Phe Leu Gly Leu Leu

340 345 350His Leu Glu Ile Ile Phe Glu Arg Ile Ile Arg Glu Phe Asp Leu Asp

355 360 365Ile Ile Ala Thr Ala Pro Ser Val Ile Tyr Lys Val Val Leu Lys Asn

370 375 380Gly Lys Val Leu Asp Ile Asp Asn Pro Ser Gly Tyr Pro Asp Pro Ala385 390 395 400Ile Ile Glu His Val Glu Glu Pro Trp Val His Val Asn Ile Ile Thr

405 410 415Pro Gln Glu Tyr Leu Ser Asn Ile Met Asn Leu Cys Leu Asp Lys Arg

420 425 430Gly Ile Cys Val Lys Thr Glu Met Leu Asp Gln His Arg Leu Val Leu

435 440 445Ala Tyr Glu Leu Pro Leu Asn Glu Ile Val Ser Asp Phe Asn Asp Lys

450 455 460Leu Lys Ser Val Thr Lys Gly Tyr Gly Ser Phe Asp Tyr Arg Leu Gly465 470 475 480Asp Tyr Arg Lys Gly Ser Ile Ile Lys Leu Glu Val Leu Ile Asn Glu

485 490 495Glu Pro Ile Asp Ala Phe Ser Cys Leu Val His Arg Asp Lys Ala Glu

500 505 510Ser Arg Gly Arg Ser Ile Cys Glu Lys Leu Val Asp Val Ile Pro Gln

515 520 525Gln Leu Phe Lys Ile Pro Ile Gln Ala Ala Ile Asn Lys Lys Val Ile

530 535 540Ala Arg Glu Thr Ile Arg Ala Leu Ser Lys Asn Val Thr Ala Lys Cys545 550 555 560Tyr Gly Gly Asp Ile Thr Arg Lys Arg Lys Leu Trp Glu Lys Gln Lys

565 570 575Lys Gly Lys Lys Arg Met Lys Glu Phe Gly Lys Val Ser Ile Pro Asn

580 585 590Thr Ala Phe Ile Glu Val Leu Lys Leu Asp

595 600<210>496<211>324<212>PRT<213>肺炎衣原体<400>496Met Glu Leu Leu Pro His Glu Lys Gln Val Val Glu Tyr Glu Lys Ala1 5 10 15Ile Ala Glu Phe Lys Glu Lys Asn Lys Lys Asn Ser Leu Leu Ser Ser

20 25 30Ser Glu Ile Gln Lys Leu Glu Lys Arg Leu Asp Lys Leu Lys Glu Lys

35 40 45Ile Tyr Ser Asp Leu Thr Pro Trp Glu Arg Val Gln Ile Cys Arg His

50 55 60Pro Ser Arg Pro Arg Thr Val Asn Tyr Ile Glu Gly Met Cys Glu Glu65 70 75 80Phe Val Glu Leu Cys Gly Asp Arg Thr Phe Arg Asp Asp Pro Ala Val

85 90 95Val Gly Gly Phe Val Lys Ile Gln Gly Gln Arg Phe Val Leu Ile Gly

100 105 110Gln Glu Lys Gly Cys Asp Thr Ala Ser Arg Leu His Arg Asn Phe Gly

115 120 125Met Leu Cys Pro Glu Gly Phe Arg Lys Ala Leu Arg Leu Gly Lys Leu

130 135 140Ala Glu Lys Phe Gly Leu Pro Val Val Phe Leu Val Asp Thr Pro Gly145 150 155 160Ala Tyr Pro Gly Leu Thr Ala Glu Glu Arg Gly Gln Gly Trp Ala Ile

165 170 175Ala Lys Asn Leu Phe Glu Leu Ser Arg Leu Ala Thr Pro Val Ile Ile

180 185 190Val Val Ile Gly Glu Gly Cys Ser Gly Gly Ala Leu Gly Met Ala Val

195 200 205Gly Asp Ser Val Ala Met Leu Glu His Ser Tyr Tyr Ser Val Ile Ser

210 215 220Pro Glu Gly Cys Ala Ser Ile Leu Trp Lys Asp Pro Lys Lys Asn Ser225 230 235 240Glu Ala Ala Ser Met Leu Lys Met His Gly Glu Asn Leu Lys Gln Phe

245 250 255Gly Ile Ile Asp Thr Val Ile Lys Glu Pro Ile Gly Gly Ala His His

260 265 270Asp Pro Ala Leu Val Tyr Ser Asn Val Arg Glu Phe Ile Ile Gln Glu

275 280 285Trp Leu Arg Leu Lys Asp Leu Ala Ile Glu Glu Leu Leu Glu Lys Arg

290 295 300Tyr Glu Lys Phe Arg Ser Ile Gly Leu Tyr Glu Thr Thr Ser Glu Ser305 310 315 320Gly Pro Glu Ala<210>497<211>659<212>PRT<213>肺炎衣原体<400>497Met Lys Leu Leu Leu Lys Ala Val Leu Arg His Lys Asn His Leu Val1 5 10 15Ile Leu Gly Cys Ser Leu Leu Ala Ile Leu Gly Leu Thr Phe Ser Ser

20 25 30Gln Met Glu Ile Phe Ser Leu Gly Met Ile Ala Lys Thr Gly Pro Asp

35 40 45Ala Phe Leu Leu Phe Gly Arg Lys Glu Ser Gly Lys Leu Val Lys Val

50 55 60Ser Glu Leu Ser Gln Lys Asp Ile Leu Glu Asn Trp Gln Ala Ile Ser65 70 75 80Lys Asp Ser Glu Thr Leu Thr Val Ser Asp Ala Thr Thr Tyr Ile Ala

85 90 95Glu His Gly Lys Ser Thr Ala Ser Leu Thr Ser Lys Leu Ser Lys Phe

100 105 110Val Arg Asn Tyr Ile Asp Val Ser Arg Phe Arg Gly Leu Ala Ile Phe

115 120 125Leu Ile Cys Val Ala Ile Phe Lys Ala Val Thr Leu Phe Phe Gln Arg

130 135 140Phe Leu Gly Gln Val Val Ala Ile Arg Val Ser Arg Asp Leu Arg Gln145 150 155 160Asp Tyr Phe Lys Ala Leu Gln Gln Leu Pro Met Thr Phe Phe His Asp

165 170 175His Asp Ile Gly Asn Leu Ser Asn Arg Val Met Thr Asp Ser Ala Ser

180 185 190Ile Ala Leu Ala Val Asn Ser Leu Met Ile Asn Tyr Ile Gln Ala Pro

195 200 205Ile Thr Phe Ile Leu Thr Leu Gly Val Cys Leu Ser Ile Ser Trp Lys

210 215 220Phe Ser Ile Leu Ile Cys Val Ala Phe Pro Ile Phe Ile Leu Pro Ile225 230 235 240Val Val Ile Ala Arg Lys Ile Lys Asn Leu Ala Lys Arg Ile Gln Lys

245 250 255Ser Gln Asp Ser Phe Ser Ser Val Leu Tyr Asp Phe Leu Ala Gly Val

260 265 270Met Thr Val Lys Val Phe Arg Thr Glu Lys Phe Ala Phe Thr Lys Tyr

275 280 285Cys Glu His Asn Asn Lys Ile Ser Ala Leu Glu Glu Lys Ser Ala Ala

290 295 300Tyr Gly Leu Leu Pro Arg Pro Leu Leu His Thr Ile Ala Ser Leu Phe305 310 315 320Phe Ala Phe Val Val Val Ile Gly Ile Tyr Lys Phe Ala Ile Pro Pro

325 330 335Glu Glu Leu Ile Val Phe Cys Gly Leu Leu Tyr Leu Ile Tyr Asp Pro

340 345 350Ile Lys Lys Phe Gly Asp Glu Asn Thr Ser Ile Met Arg Gly Cys Ala

355 360 365Ala Ala Glu Arg Phe Tyr Glu Val Leu Asn His Pro Asp Leu His Ser

370 375 380Gln Lys Glu Arg Glu Ile Glu Phe Leu Gly Leu Ser Asn Thr Ile Thr385 390 395 400Phe Glu Asn Val Ser Phe Gly Tyr Gln Glu Asp Lys His Ile Leu Lys

405 410 415Asn Leu Ser Phe Thr Leu His Lys Gly Glu Ala Leu Gly Ile Val Gly

420 425 430Pro Thr Gly Ser Gly Lys Thr Thr Leu Val Lys Leu Leu Pro Arg Leu

435 440 445Tyr Glu Val Ser Gln Gly Lys Ile Leu Ile Asp Ser Leu Pro Ile Thr

450 455 460Glu Tyr Asn Lys Gly Ser Leu Arg Asn His Ile Ala Cys Val Leu Gln465 470 475 480Asn Pro Phe Leu Phe Tyr Asp Thr Val Trp Asn Asn Leu Thr Cys Gly

485 490 495Lys Asp Met Glu Glu Glu Ala Val Leu Glu Ala Leu Lys Arg Ala Tyr

500 505 510Ala Asp Glu Phe Ile Leu Lys Leu Pro Lys Gly Val His Ser Val Leu

515 520 525Glu Glu Ser Gly Lys Asn Leu Ser Gly Gly Gln Gln Gln Arg Leu Ala

530 535 540Ile Ala Arg Ala Leu Leu Lys Asn Ala Ser Ile Leu Ile Leu Asp Glu545 550 555 560Ala Thr Ser Ala Leu Asp Ala Ile Ser Glu Asn Tyr Ile Lys Asn Ile

565 570 575Ile Gly Glu Leu Lys Gly Gln Cys Thr Gln Ile Ile Ile Ala His Lys

580 585 590Leu Thr Thr Leu Glu His Val Asp Arg Val Leu Tyr Ile Glu Asn Gly

595 600 605Gln Lys Ile Ala Glu Gly Thr Lys Glu Glu Leu Leu Gln Thr Cys Pro

610 615 620Glu Phe Leu Lys Met Trp Glu Leu Ser Gly Thr Lys Glu Tyr Asn Arg625 630 635 640Val Phe Val Pro Asp His Lys Leu Val Ala Asn Pro Thr Asp Met Ala

645 650 655Ile Thr Thr<210>498<211>411<212>PRT<213>肺炎衣原体<400>498Met Ile Pro Thr Met Leu Met Phe Phe Ile Ile Cys Phe Thr Leu Cys1 5 10 15Ser Gly Phe Ile Ser Leu Ser Gln Ile Ala Leu Phe Ser Leu Pro Thr

20 25 30Ser Leu Ile Ser His Tyr Lys Arg Ser Lys Ser Lys Lys Gln Gln Arg

35 40 45Val Ala Thr Leu Leu Leu His Pro His His Leu Leu Ile Thr Leu Ile

50 55 60Phe Cys Asp Ile Gly Leu Asn Ile Ala Ile Gln Asn Cys Phe Ala Ile65 70 75 80Leu Phe Gly Asp Ala Ala Ser Trp Trp Phe Thr Val Gly Leu Pro Leu

85 90 95Ala Ile Thr Leu Ile Leu Gly Glu Ile Leu Pro Lys Ala Val Ala Leu

100 105 110Pro Phe Asn Thr Gln Ile Ala Ser Ser Val Ala Pro Leu Ile Leu Cys

115 120 125Val Thr Lys Ile Phe Lys Pro Leu Leu His Trp Gly Ile Val Gly Ile

130 135 140Asn Tyr Val Val Gln Trp Ile Leu Ser Lys Gln Gln Ile Asp Ile Ile145 150 155 160Gln Pro Gln Glu Leu Lys Glu Val Leu Gln Ser Cys Lys Asp Phe Gly

165 170 175Val Val Asn Gln Glu Glu Ser Arg Leu Leu Tyr Gly Tyr Leu Ser Leu

180 185 190Ser Asp Cys Ser Val Lys Glu Arg Met Gln Pro Arg Gln Asp Ile Leu

195 200 205Phe Tyr Asp Ile Gln Thr Pro Leu Glu Asn Leu Tyr Leu Leu Phe Ser

210 215 220Lys Gln His Cys Ser Arg Val Pro Ile Cys Asn Asp Asn Leu Gln Asn225 230 235 240Leu Leu Gly Ile Cys Thr Ala Arg Ser Leu Leu Leu His Asp Lys Pro

245 250 255Leu Gln Ser Ser Asp Asp Leu Leu Pro Leu Leu Lys Lys Pro Tyr Tyr

260 265 270Met Pro Glu Thr Ile Ser Ala Lys Met Ala Leu Cys Gln Met Ala Ala

275 280 285Glu Asp Glu Thr Leu Gly Met Ile Ile Asp Glu Tyr Gly Ser Ile Glu

290 295 300Gly Leu Ile Thr Gln Glu Asp Leu Phe Glu Ile Val Ala Gly Glu Ile305 310 315 320Val Asp Gln Arg Asp Asn Lys Ile Leu Tyr Thr Thr Ser Gly Ala Asp

325 330 335Val Ile Ile Ala Ser Gly Thr Leu Glu Leu Arg Glu Phe Ser Glu Ile

340 345 350Phe Asp Ile Asn Leu Pro Thr Asn Asn Asn Ile Ala Thr Ile Gly Gly

355 360 365Trp Leu Ile Glu Gln Ile Gly Thr Ile Pro Thr Thr Gly Met Lys Leu

370 375 380Ser Trp Asn Asn Leu Leu Phe Gln Val Leu Asp Ala Ala Pro Asn Arg385 390 395 400Ile Arg Arg Val Tyr Ile Arg Lys Leu Tyr Asp

405 410<210>499<211>404<212>PRT<213>肺炎衣原体<400>499Met Thr Asn Ser Ala Leu Phe Trp Ile Gly Val Asn Ile Ile Cys Ile1 5 10 15Val Leu Gln Gly Phe Tyr Ser Met Met Glu Met Ala Cys Val Ser Phe

20 25 30Asn Arg Val Arg Leu Gln Tyr Tyr Leu Thr Lys Asp His Lys Lys Ala

35 40 45Arg Tyr Ile Asn Phe Leu Ile Arg Arg Pro Tyr Arg Leu Phe Gly Thr

50 55 60Val Met Leu Gly Val Asn Ile Ala Leu Gln Val Gly Ser Glu Ser Ser65 70 75 80Arg Asn Cys Tyr Arg Ala Leu Gly Ile Thr Pro Asp Tyr Ala Pro Phe

85 90 95Thr Gln Ile Phe Ile Val Val Ile Phe Ala Glu Leu Leu Pro Leu Thr

100 105 110Ile Ser Arg Lys Ile Pro Glu Lys Leu Ala Leu Trp Gly Ala Pro Ile

115 120 125Leu Tyr Tyr Ser His Tyr Ile Phe Tyr Pro Leu Ile Gln Leu Ile Gly

130 135 140Ser Leu Thr Glu Gly Leu Tyr Tyr Leu Leu Asn Ile Arg Lys Glu Lys145 150 155 160Leu Asn Ser Thr Leu Ser Arg Asp Glu Phe Gln Lys Ala Leu Glu Thr

165 170 175His His Glu Glu Gln Asp Phe Asn Thr Ile Ala Thr Asn Ile Phe Ser

180 185 190Leu Ser Ala Thr Cys Ala Asp Gln Val Cys Gln Pro Leu Glu Gln Val

195 200 205Thr Met Leu Pro Ser Ser Ala Asn Val Lys Asp Phe Cys Arg Thr Ile

210 215 220Lys Asn Thr Asp Ile Asn Phe Ile Pro Val Tyr His Lys Ala Arg Lys225 230 235 240Asn Val Ile Gly Ile Ala His Pro Lys Asp Phe Val Asn Lys Ala Leu

245 250 255Asp Glu Pro Leu Ile Asn Asn Leu His Ser Pro Trp Phe Ile Thr Ala

260 265 270Lys Ser Lys Leu Ile Arg Ile Leu Lys Glu Phe Arg Asp Asn Arg Ser

275 280 285Ser Val Ala Val Val Leu Asn Ala Ser Gly Glu Pro Ile Gly Ile Leu

290 295 300Ser Leu Asn Ala Ile Phe Lys Ile Leu Phe Asn Thr Thr Asn Ile Ala305 310 315 320His Leu Lys Pro Lys Thr Ile Ser Val Ile Glu Arg Thr Phe Pro Gly

325 330 335Asn Ser Arg Ile Lys Asp Leu Gln Lys Glu Leu Asp Ile Gln Phe Pro

340 345 350Gln Tyr Pro Val Glu Thr Leu Ala Gln Leu Val Leu Gln Leu Leu Asp

355 360 365Ser Pro Ala Glu Val Gly Thr Ser Val Ile Ile Asn Asn Leu Leu Leu

370 375 380Glu Val Lys Glu Met Ser Leu Ser Gly Ile Lys Thr Val Ser Ile Lys385 390 395 400Asn Leu Leu Ser<210>500<211>543<212>PRT<213>肺炎衣原体<400>500Met Phe Gly Ser Glu Ser Leu Arg Tyr Gln Leu Leu Ile Gln Asp Phe1 5 10 15Ala Lys Val Ser Glu Glu Gly Ile Gly Leu Leu Glu Ser Lys Glu Tyr

20 25 30Ser Leu Leu Gln Ala Lys Leu Val Leu Arg Ala Leu Ala Gln Asn Ser

35 40 45Ser Phe Asp Asp Trp Phe Arg Ser Phe Lys Lys Cys Gln Ile Ser Tyr

50 55 60Pro Glu Leu Ala His Asp Arg Asp Val Leu Glu Glu Phe Gly Ile Gln65 70 75 80Val Leu Arg Glu Gly Ile Glu Asn Pro Ser Val Thr Val Arg Ala Val

85 90 95Ser Val Leu Ala Ile Gly Leu Ala Arg Asp Phe Arg Leu Val Pro Leu

100 105 110Leu Leu Gln Ser Cys Asn Asp Asp Ser Ala Ile Val Arg Ser Leu Ala

115 120 125Leu Gln Val Ala Val Asn Tyr Gly Ser Glu Ser Leu Lys Lys Ala Ile

130 135 140Val Glu Leu Ala Arg Asn Asp Asp Ser Ile His Val Arg Ile Thr Ala145 150 155 160Tyr Gln Val Val Ala Leu Leu Gln Ile Glu Glu Leu Leu Pro Phe Leu

165 170 175Arg Glu Arg Ala Glu Asn Lys Leu Val Asp Ser Val Glu Arg Arg Glu

180 185 190Ala Trp Lys Ala Cys Leu Glu Leu Ser Ser Gln Phe Leu Glu Thr Gly

195 200 205Val Ala Lys Asp Asp Ile Asp Gln Ala Leu Phe Thr Cys Glu Val Leu

210 215 220Arg Asn Gly Met Leu Pro Glu Thr Thr Glu Ile Phe Thr Glu Leu Leu225 230 235 240Ser Val Glu His Pro Glu Val Gln Glu Ser Leu Leu Leu Ser Ala Leu

245 250 255Ala Trp Ser His Gln Leu Gln Asn His Lys Glu Phe Leu Ser Lys Val

260 265 270Arg His Val Met Cys Thr Ser Pro Phe Ala Lys Val Arg Phe Gln Ala

275 280 285Ala Ala Leu Leu His Leu His Gly Asp Pro Leu Gly Arg Asp Ser Leu

290 295 300Val Glu Gly Leu Arg Ser Pro Gln Pro Leu Val Cys Glu Ala Ala Ser305 310 315 320Ala Ala Leu Cys Ser Leu Gly Ile His Gly Val Pro Leu Ala Lys Glu

325 330 335His Leu Glu Ser Leu Ser Ser Arg Lys Ala Ala Ala Asn Leu Ser Ile

340 345 350Leu Leu Leu Val Ser Arg Glu Asp Ile Glu Arg Ala Gly Asp Val Ile

355 360 365Ala Arg Tyr Leu Ser Asn Pro Glu Met Cys Trp Ala Ile Glu Tyr Phe

370 375 380Leu Trp Asp Ala Gln Trp Asn Leu Arg Gly Asp Thr Phe Pro Leu Tyr385 390 395 400Ser Asp Met Ile Lys Arg Glu Ile Gly Arg Lys Leu Ile Arg Leu Leu

405 410 415Ala Val Ala Arg Tyr Ser Gln Ala Lys Ala Val Thr Ala Thr Phe Leu

420 425 430Ser Gly Gln Gln Ala Gln Gly Trp Ser Phe Phe Ser Gly Met Phe Trp

435 440 445Glu Glu Gly Asp Val Lys Thr Ser Glu Asp Leu Val Thr Asp Ala Cys

450 455 460Phe Ala Ala Lys Leu Glu Gly Ala Leu Ala Ser Leu Cys Gln Lys Lys465 470 475 480Asp Gln Ala Ser Leu Gln Arg Val Ser Gln Leu Tyr Asn Asp Ser Arg

485 490 495Trp Gln Asp Lys Leu Ala Ile Leu Glu Ser Val Ala Phe Ser Glu Asn

500 505 510Leu Asp Ala Val Pro Phe Leu Leu Asp Cys Cys His His Glu Ala Pro

515 520 525Ser Leu Arg Ser Ala Ala Ala Gly Ala Leu Phe Ser Ile Phe Lys

530 535 540<210>501<211>103<212>PRT<213>肺炎衣原体<400>501Met Ser Phe Lys Arg Phe Leu Gln Gln Ile Pro Val Arg Ile Cys Leu1 5 10 15Leu Ile Ile Tyr Leu Tyr Gln Trp Leu Ile Ser Pro Leu Leu Gly Ser

20 25 30Cys Cys Arg Phe Phe Pro Ser Cys Ser His Tyr Ala Glu Gln Ala Leu

35 40 45Lys Ser His Gly Phe Leu Met Gly Cys Trp Leu Ser Ile Lys Arg Ile

50 55 60Gly Lys Cys Gly Pro Trp His Pro Gly Gly Ile Asp Met Val Pro Lys65 70 75 80Thr Ala Leu Gln Glu Val Leu Glu Pro Tyr Gln Glu Ile Asp Gly Gly

85 90 95Asp Ser Ser His Phe Ser Glu

100<210>502<211>362<212>PRT<213>肺炎衣原体<400>502Met Ala Phe Lys Arg Lys Thr Arg Trp Leu Trp Gln Val Leu Ile Leu1 5 10 15Ser Val Gly Leu Asn Met Leu Phe Leu Leu Leu Phe Tyr Ser Ala Ile

20 25 30Phe Arg Lys Asp Ile Tyr Lys Leu His Leu Phe Ser Gly Pro Leu Ile

35 40 45Ala Lys Ser Ser Arg Lys Val Tyr Leu Ser Glu Asp Phe Leu Asn Glu

50 55 60Ile Ser Gln Ala Ser Leu Asp Asp Leu Ile Ser Leu Phe Lys Asp Glu65 70 75 80Arg Tyr Met Tyr Gly Arg Pro Ile Lys Leu Trp Ala Leu Ser Val Ala

85 90 95Ile Ala Ser His His Ile Asp Ile Thr Pro Val Leu Ser Lys Pro Leu

100 105 110Thr Tyr Thr Glu Leu Lys Gly Ser Ser Val Arg Trp Leu Leu Pro Asn

115 120 125Ile Asp Leu Lys Asp Phe Pro Val Ile Leu Asp Tyr Leu Arg Cys His

130 135 140Lys Tyr Pro Tyr Thr Ser Lys Gly Leu Phe Leu Leu Ile Glu Lys Met145 150 155 160Val Gln Glu Gly Trp Val Asp Glu Asp Cys Leu Tyr His Phe Cys Ser

165 170 175Thr Pro Glu Phe Leu Tyr Leu Arg Thr Leu Leu Val Gly Ala Asp Val

180 185 190Gln Ala Ser Ser Val Ala Ser Leu Ala Arg Met Val Ile Arg Cys Gly

195 200 205Ser Glu Arg Phe Phe His Phe Cys Asn Glu Glu Ser Arg Thr Ser Met

210 215 220Ile Ser Ala Thr Gln Arg Gln Lys Val Leu Lys Ser Tyr Leu Asp Cys225 230 235 240Glu Glu Ser Leu Ala Ala Leu Leu Leu Leu Val His Asp Ser Asp Val

245 250 255Val Leu His Glu Phe Cys Asp Glu Asp Leu Glu Lys Val Ile Arg Leu

260 265 270Met Pro Gln Glu Ser Pro Tyr Ser Gln Asn Phe Phe Ser Arg Leu Gln

275 280 285His Ser Pro Arg Arg Glu Leu Ala Cys Met Ser Thr Gln Arg Val Glu

290 295 300Ala Pro Arg Val Gln Glu Asp Gln Asp Glu Glu Tyr Val Val Gln Asp305 310 315 320Gly Asp Ser Leu Trp Leu Ile Ala Lys Arg Phe Gly Ile Pro Met Asp

325 330 335Lys Ile Ile Gln Lys Asn Gly Leu Asn His His Arg Leu Phe Pro Gly

340 345 350Lys Val Leu Lys Leu Pro Ala Lys Gln Ser

355 360<210>503<211>582<212>PRT<213>肺炎衣原体<400>503Met Ser Gly Lys Lys Asp Gly Val Arg Gly Met Ile Phe Val Pro Leu1 5 10 15Ser Ile Leu Val Leu Ile Phe Leu Pro Leu Pro Gln Ile Leu Leu Asp

20 25 30Phe Gly Leu Cys Ile Ser Phe Ala Leu Ser Leu Leu Thr Val Cys Trp

35 40 45Val Phe Thr Leu Asn Ser Ser Asn Ser Ala Lys Leu Phe Pro Pro Phe

50 55 60Phe Leu Tyr Leu Cys Leu Leu Arg Leu Gly Leu Asn Leu Ala Ser Thr65 70 75 80Arg Trp Ile Val Ser Ser Gly Thr Ala Ser Ser Leu Ile Val Ser Leu

85 90 95Gly Ser Phe Phe Ser Leu Gly Ser Leu Trp Ala Ala Thr Phe Ala Cys

100 105 110Leu Leu Leu Phe Phe Val Asn Phe Leu Met Val Ser Lys Gly Ser Glu

115 120 125Arg Ile Ala Glu Val Arg Ser Arg Phe Phe Leu Glu Ala Leu Pro Ala

130 135 140Lys Gln Met Ala Leu Asp Ser Asp Leu Val Ser Gly Arg Ala Ser Tyr145 150 155 160Lys Ala Val Lys Lys Gln Lys Asn Ala Leu Ile Glu Glu Gly Asp Phe

165 170 175Phe Ser Ala Met Glu Gly Val Phe Arg Phe Val Lys Gly Asp Ala Ile

180 185 190Ile Ser Cys Ile Leu Leu Leu Val Asn Val Val Ser Val Thr Cys Leu

195 200 205Tyr Tyr Thr Ser Gly Tyr Ala Leu Glu Gln Met Trp Phe Thr Val Leu

210 215 220Gly Asp Ala Leu Val Ser Gln Val Pro Ala Leu Leu Thr Ser Cys Ala225 230 235 240Ala Ala Thr Leu Ile Ser Lys Ile Asp Lys Glu Glu Ser Leu Leu Asn

245 250 255Tyr Leu Phe Glu Tyr Tyr Lys Gln Leu Arg Gln His Phe Arg Val Val

260 265 270Ser Leu Leu Ile Phe Ser Leu Cys Cys Ile Pro Ser Ser Pro Lys Phe

275 280 285Pro Ile Val Leu Leu Ala Ser Leu Leu Trp Leu Ala Tyr Arg Lys Glu

290 295 300Glu Pro Ala Ser Glu Asp Ser Cys Ile Glu Arg Ala Phe Ser Tyr Val305 310 315 320Glu Gly Ala Cys Pro Lys Glu Gln Glu Ser Gln Phe Tyr Gln Val Tyr

325 330 335Arg Ala Ala Ser Glu Glu Val Phe Glu Asp Leu Gly Val Arg Leu Pro

340 345 350Val Leu Thr Ser Leu Arg Ile Glu Glu Arg Pro Trp Leu Arg Val Phe

355 360 365Gly Gln Asn Val Tyr Leu Asp Glu Met Thr Pro Glu Ala Val Leu Pro

370 375 380Phe Leu Arg Asn Ile Ala His Glu Ala Leu Asn Ala Glu Val Val Gln385 390 395 400Lys Tyr Leu Glu Glu Ser Glu Arg Val Phe Gly Ile Ala Val Glu Asp

405 410 415Ile Val Pro Lys Lys Ile Ser Leu Ser Ser Leu Val Val Leu Ser Arg

420 425 430Leu Leu Val Arg Glu Arg Val Ser Leu Lys Leu Phe Pro Lys Ile Leu

435 440 445Glu Ala Val Ala Val Tyr Gln Asn Ser Gly Asp Ser Leu Glu Ile Leu

450 455 460Ala Glu Lys Val Arg Lys Ser Leu Gly Tyr Trp Ile Gly Arg Ser Leu465 470 475 480Trp Asp Gln Lys Gln Thr Leu Glu Val Ile Thr Ile Asp Phe His Val

485 490 495Glu Glu Leu Ile Asn Ser Ser Tyr Ser Lys Ser Asn Pro Val Met Gln

500 505 510Glu Asn Val Ile Arg Arg Val Asp Ser Leu Leu Glu Arg Ser Val Phe

515 520 525Lys Asp Phe Arg Ala Ile Val Thr Ser Cys Glu Thr Arg Phe Glu Met

530 535 540Lys Lys Met Leu Asp Pro His Phe Pro Asp Leu Leu Val Leu Ser His545 550 555 560Asp Glu Leu Pro Lys Glu Ile Pro Ile Ser Phe Leu Gly Ile Val Ser

565 570 575Asp Glu Val Leu Val Pro

580<210>504<211>435<212>PRT<213>肺炎衣原体<400>504Met Phe Ser Arg Trp Ile Thr Leu Phe Leu Leu Phe Ile Ser Leu Thr1 5 10 15Gly Cys Ser Ser Tyr Ser Ser Lys His Lys Gln Ser Leu Ile Ile Pro

20 25 30Ile His Asp Asp Pro Val Ala Phe Ser Pro Glu Gln Ala Lys Arg Ala

35 40 45Met Asp Leu Ser Ile Ala Gln Leu Leu Phe Asp Gly Leu Thr Arg Glu

50 55 60Thr His Arg Glu Ser Asn Asp Leu Glu Leu Ala Ile Ala Ser Arg Tyr65 70 75 80Thr Val Ser Glu Asp Phe Cys Ser Tyr Thr Phe Phe Ile Lys Asp Ser

85 90 95Ala Leu Trp Ser Asp Gly Thr Pro Ile Thr Ser Glu Asp Ile Arg Asn

100 105 110Ala Trp Glu Tyr Ala Gln Glu Asn Ser Pro His Ile Gln Ile Phe Gln

115 120 125Gly Leu Asn Phe Ser Thr Pro Ser Ser Asn Ala Ile Thr Ile His Leu

130 135 140Asp Ser Pro Asn Pro Asp Phe Pro Lys Leu Leu Ala Phe Pro Ala Phe145 150 155 160Ala Ile Phe Lys Pro Glu Asn Pro Lys Leu Phe Ser Gly Pro Tyr Thr

165 170 175Leu Val Glu Tyr Phe Pro Gly His Asn Ile His Leu Lys Lys Asn Pro

180 185 190Asn Tyr Tyr Asp Tyr His Cys Val Ser Ile Asn Ser Ile Lys Leu Leu

195 200 205Ile Ile Pro Asp Ile Tyr Thr Ala Ile His Leu Leu Asn Arg Gly Lys

210 215 220Val Asp Trp Val Gly Gln Pro Trp His Gln Gly Ile Pro Trp Glu Leu225 230 235 240His Lys Gln Ser Gln Tyr His Tyr Tyr Thr Tyr Pro Val Glu Gly Ala

245 250 255Phe Trp Leu Cys Leu Asn Thr Lys Ser Pro His Leu Asn Asp Leu Gln

260 265 270Asn Arg His Arg Leu Ala Thr Cys Ile Asp Lys Arg Ser Ile Ile Glu

275 280 285Glu Ala Leu Gln Gly Thr Gln Gln Pro Ala Glu Thr Leu Ser Arg Gly

290 295 300Ala Pro Gln Pro Asn Gln Tyr Lys Lys Gln Lys Pro Leu Thr Pro Gln305 310 315 320Glu Lys Leu Val Leu Thr Tyr Pro Ser Asp Ile Leu Arg Cys Gln Arg

325 330 335Ile Ala Glu Ile Leu Lys Glu Gln Trp Lys Ala Ala Gly Ile Asp Leu

340 345 350Ile Leu Glu Gly Leu Glu Tyr His Leu Phe Val Asn Lys Arg Lys Val

355 360 365Gln Asp Tyr Ala Ile Ala Thr Gln Thr Gly Val Ala Tyr Tyr Pro Gly

370 375 380Ala Asn Leu Ile Ser Glu Glu Asp Lys Leu Leu Gln Asn Phe Glu Ile385 390 395 400Ile Pro Ile Tyr Tyr Leu Ser Tyr Asp Tyr Leu Thr Gln Asp Phe Ile

405 410 415Glu Gly Val Ile Tyr Asn Ala Ser Gly Ala Val Asp Leu Lys Tyr Thr

420 425 430Tyr Phe Pro

435<210>505<211>171<212>PRT<213>肺炎衣原体<400>505Met Lys Lys Leu Leu Phe Ser Thr Phe Leu Leu Val Leu Gly Ser Thr1 5 10 15Ser Ala Ala His Ala Asn Leu Gly Tyr Val Asn Leu Lys Arg Cys Leu

20 25 30Glu Glu Ser Asp Leu Gly Lys Lys Glu Thr Glu Glu Leu Glu Ala Met

35 40 45Lys Gln Gln Phe Val Lys Asn Ala Glu Lys Ile Glu Glu Glu Leu Thr

50 55 60Ser Ile Tyr Asn Lys Leu Gln Asp Glu Asp Tyr Met Glu Ser Leu Ser65 70 75 80Asp Ser Ala Ser Glu Glu Leu Arg Lys Lys Phe Glu Asp Leu Ser Gly

85 90 95Glu Tyr Asn Ala Tyr Gln Ser Gln Tyr Tyr Gln Ser Ile Asn Gln Ser

100 105 110Asn Val Lys Arg Ile Gln Lys Leu Ile Gln Glu Val Lys Ile Ala Ala

115 120 125Glu Ser Val Arg Ser Lys Glu Lys Leu Glu Ala Ile Leu Asn Glu Glu

130 135 140Ala Val Leu Ala Ile Ala Pro Gly Thr Asp Lys Thr Thr Glu Ile Ile145 150 155 160Ala Ile Leu Asn Glu Ser Phe Lys Lys Gln Asn

165 170<210>506<211>360<212>PRT<213>肺炎衣原体<400>506Met Ser Glu Ala Pro Val Tyr Thr Leu Lys Gln Leu Ala Glu Leu Leu1 5 10 15Gln Val Glu Val Gln Gly Asn Ile Glu Thr Pro Ile Ser Gly Val Glu

20 25 30Asp Ile Ser Gln Ala Gln Pro His His Ile Ala Phe Leu Asp Asn Glu

35 40 45Lys Tyr Ser Ser Phe Leu Lys Asn Thr Lys Ala Gly Ala Ile Ile Leu

50 55 60Ser Arg Ser Gln Ala Met Gln His Ala His Leu Lys Lys Asn Phe Leu65 70 75 80Ile Thr Asn Glu Ser Pro Ser Leu Thr Phe Gln Lys Cys Ile Glu Leu

85 90 95Phe Ile Glu Pro Val Thr Ser Gly Phe Pro Gly Ile His Pro Thr Ala

100 105 110Val Ile His Pro Thr Ala Arg Ile Glu Lys Asn Val Thr Ile Glu Pro

115 120 125Tyr Val Val Ile Ser Gln His Ala His Ile Gly Ser Asp Thr Tyr Ile

130 135 140Gly Ala Gly Ser Val Ile Gly Ala His Ser Val Leu Gly Ala Asn Cys145 150 155 160Leu Ile His Pro Lys Val Val Ile Arg Glu Arg Val Leu Met Gly Asn

165 170 175Arg Val Val Val Gln Pro Gly Ala Val Leu Gly Ser Cys Gly Phe Gly

180 185 190Tyr Ile Thr Asn Ala Phe Gly His His Lys Pro Leu Lys His Leu Gly

195 200 205Tyr Val Ile Val Gly Asp Asp Val Glu Ile Gly Ala Asn Thr Thr Ile

210 215 220Asp Arg Gly Arg Phe Lys Asn Thr Val Ile His Glu Gly Thr Lys Ile225 230 235 240Asp Asn Gln Val Gln Val Ala His His Val Glu Ile Gly Lys His Ser

245 250 255Ile Ile Val Ala Gln Ala Gly Ile Ala Gly Ser Thr Lys Ile Gly Glu

260 265 270His Val Ile Ile Gly Gly Gln Thr Gly Ile Thr Gly His Ile Ser Ile

275 280 285Ala Asp His Val Ile Met Ile Ala Gln Thr Gly Val Thr Lys Ser Ile

290 295 300Thr Ser Pro Gly Ile Tyr Gly Gly Ala Pro Ala Arg Pro Tyr Gln Glu305 310 315 320Thr His Arg Leu Ile Ala Lys Ile Arg Asn Leu Pro Lys Thr Glu Glu

325 330 335Arg Leu Ser Lys Leu Glu Lys Gln Val Arg Asp Leu Ser Thr Pro Ser

340 345 350Leu Ala Glu Ile Pro Ser Glu Ile

355 360<210>507<211>399<212>PRT<213>肺炎衣原体<400>507Met Ala Ala Ser Gly Gly Thr Gly Gly Leu Gly Gly Thr Gln Gly Val1 5 10 15Asn Leu Ala Ala Val Glu Ala Ala Ala Ala Lys Ala Asp Ala Ala Glu

20 25 30Val Val Ala Ser Gln Glu Gly Ser Glu Met Asn Met Ile Gln Gln Ser

35 40 45Gln Asp Leu Thr Asn Pro Ala Ala Ala Thr Arg Thr Lys Lys Lys Glu

50 55 60Glu Lys Phe Gln Thr Leu Glu Ser Arg Lys Lys Gly Glu Ala Gly Lys65 70 75 80Ala Glu Lys Lys Ser Glu Ser Thr Glu Glu Lys Pro Asp Thr Asp Leu

85 90 95Ala Asp Lys Tyr Ala Ser Gly Asn Ser Glu Ile Ser Gly Gln Glu Leu

100 105 110Arg Gly Leu Arg Asp Ala Ile Gly Asp Asp Ala Ser Pro Glu Asp Ile

115 120 125Leu Ala Leu Val Gln Glu Lys Ile Lys Asp Pro Ala Leu Gln Ser Thr

130 135 140Ala Leu Asp Tyr Leu Val Gln Thr Thr Pro Pro Ser Gln Gly Lys Leu145 150 155 160Lys Glu Ala Leu Ile Gln Ala Arg Asn Thr His Thr Glu Gln Phe Gly

165 170 175Arg Thr Ala Ile Gly Ala Lys Asn Ile Leu Phe Ala Ser Gln Glu Tyr

180 185 190Ala Asp Gln Leu Asn Val Ser Pro Ser Gly Leu Arg Ser Leu Tyr Leu

195 200 205Glu Val Thr Gly Asp Thr His Thr Cys Asp Gln Leu Leu Ser Met Leu

210 215 220Gln Asp Arg Tyr Thr Tyr Gln Asp Met Ala Ile Val Ser Ser Phe Leu225 230 235 240Met Lys Gly Met Ala Thr Glu Leu Lys Arg Gln Gly Pro Tyr Val Pro

245 250 255Ser Ala Gln Leu Gln Val Leu Met Thr Glu Thr Arg Asn Leu Gln Ala

260 265 270Val Leu Thr Ser Tyr Asp Tyr Phe Glu Ser Arg Val Pro Ile Leu Leu

275 280 285Asp Ser Leu Lys Ala Glu Gly Ile Gln Thr Pro Ser Asp Leu Asn Phe

290 295 300Val Lys Val Ala Glu Ser Tyr His Lys Ile Ile Asn Asp Lys Phe Pro305 310 315 320Thr Ala Ser Lys Val Glu Arg Glu Val Arg Asn Leu Ile Gly Asp Asp

325 330 335Val Asp Ser Val Thr Gly Val Leu Asn Leu Phe Phe Ser Ala Leu Arg

340 345 350Gln Thr Ser Ser Arg Leu Phe Ser Ser Ala Asp Lys Arg Gln Gln Leu

355 360 365Gly Ala Met Ile Ala Asn Ala Leu Asp Ala Val Asn Ile Asn Asn Glu

370 375 380Asp Tyr Pro Lys Ala Ser Asp Phe Pro Lys Pro Tyr Pro Trp Ser385 390 395<210>508<211>224<212>PRT<213>肺炎衣原体<400>508Met Thr Ser Trp Ile Glu Leu Leu Asp Lys Gln Ile Glu Asp Gln His1 5 10 15Met Leu Lys His Glu Phe Tyr Gln Arg Trp Ser Glu Gly Lys Leu Glu

20 25 30Lys Gln Gln Leu Gln Ala Tyr Ala Lys Asp Tyr Tyr Leu His Ile Lys

35 40 45Ala Phe Pro Cys Tyr Leu Ser Ala Leu His Ala Arg Cys Asp Asp Leu

85 90 95Val Ser Glu Glu Glu Leu Ala Asn His Glu Phe Ser Gln Ala Ala Gln

100 105 110Asp Met Val Ala Thr Phe Arg Arg Leu Cys Asp Met Pro Gln Leu Ala

115 120 125Val Gly Leu Gly Ala Leu Tyr Thr Tyr Glu Ile Gln Ile Pro Gln Val

l65 170 175Ala Ser Glu Glu Lys Glu Met Leu Gln Thr Leu Val Gly Arg Glu Asn

180 185 190Pro Asp Ala Val Leu Gln Gly Ser Gln Glu Val Leu Asp Thr Leu Trp

195 200 205Asn Phe Leu Ser Ser Phe Ile Asn Ser Thr Glu Pro Cys Ser Cys Lys

210 215 220<210>509<211>246<212>PRT<213>肺炎衣原体<400>509Met Lys Ile Thr Thr Val Lys Thr Pro Lys Ile Tyr Pro Tyr Asp Asp1 5 10 15Leu Tyr Ser Ile Leu Glu Ser Ser Leu Pro Lys Leu Asn Glu Arg Ser

20 25 30Ile Val Val Ile Thr Ser Lys Ile Val Ser Leu Cys Glu Gly Ala Val

35 40 45Val Glu Leu Glu Lys Val Ser Lys Asp Glu Leu Ile Lys Gln Glu Ala

50 55 60Asp Ala Tyr Val Phe Val Glu Lys Tyr Gly Ile Tyr Leu Thr Lys Lys65 70 75 80Trp Gly Ile Leu Ile Pro Ser Ala Gly Ile Asp Glu Ser Asn Val Glu

85 90 95Gly Tyr Phe Val Leu Tyr Pro Arg Asp Phe Leu Leu Ser Val Asn Thr

100 105 110Leu Gly Asp Trp Leu Arg Asn Phe Tyr His Leu Glu His Cys Gly Ile

115 120 125Ile Ile Ser Asp Ser His Thr Thr Pro Leu Arg Arg Gly Thr Met Gly

130 135 140Leu Gly Leu Cys Trp Asn Gly Phe Phe Pro Leu Tyr Asn Tyr Val Gly145 150 155 160Lys Pro Asp Cys Phe Gly Arg Ala Leu Lys Met Thr Tyr Ser Asn Leu

165 170 175Leu Asp Gly Leu Ser Ala Ala Ala Val Leu Cys Met Gly Glu Gly Asp

180 185 190Glu Gln Thr Pro Ile Ala Ile Ile Glu Glu Ala Pro Lys Ile Thr Phe

195 200 205His Ser Ser Pro Thr Thr Leu Gln Asp Met Ser Thr Leu Ala Ile Ala

210 215 220Glu Asp Glu Asp Leu Tyr Gly Pro Leu Leu Gln Ser Met Ala Trp Glu225 230 235 240Thr Pro Ala Pro Thr Ser

245<210>510<211>353<212>PRT<213>肺炎衣原体<400>510Met Asn Lys Arg Gln Lys Asp Lys Leu Lys Ile Cys Val Ile Ile Ser1 5 10 15Thr Leu Ile Leu Val Gly Ile Phe Ala Arg Ala Pro Arg Gly Asp Thr

20 25 30Phe Lys Thr Phe Leu Lys Ser Glu Glu Ala Ile Ile Tyr Ser Asn Gln

35 40 45Cys Asn Glu Asp Met Arg Lys Ile Leu Cys Asp Ala Ile Glu His Ala

50 55 60Asp Glu Glu Ile Phe Leu Arg Ile Tyr Asn Leu Ser Glu Pro Lys Ile65 70 75 80Gln Gln Ser Leu Thr Arg Gln Ala Gln Ala Lys Asn Lys Val Thr Ile

85 90 95Tyr Tyr Gln Lys Phe Lys Ile Pro Gln Ile Leu Lys Gln Ala Ser Asn

100 105 110Val Thr Leu Val Glu Gln Pro Pro Ala Gly Arg Lys Leu Met His Gln

115 120 125Lys Ala Leu Ser Ile Asp Lys Lys Asp Ala Trp Leu Gly Ser Ala Asn

130 135 140Tyr Thr Asn Leu Ser Leu Arg Leu Asp Asn Asn Leu Ile Leu Gly Met145 150 155 160His Ser Ser Glu Leu Cys Asp Leu Ile Ile Thr Asn Thr Ser Gly Asp

165 170 175Phe Ser Ile Lys Asp Gln Thr Gly Lys Tyr Phe Val Leu Pro Gln Asp

180 185 190Arg Lys Ile Ala Ile Gln Ala Val Leu Glu Lys Ile Gln Thr Ala Gln

195 200 205Lys Thr Ile Gln Val Ala Met Phe Ala Leu Thr His Ser Glu ILe Ile

210 215 220Gln Ala Leu His Gln Ala Lys Gln Arg Gly Ile His Val Asp Ile Ile225 230 235 240Ile Asp Arg Ser His Ser Lys Leu Thr Phe Lys Gln Leu Arg Gln Leu

245 250 255Asn Ile Asn Lys Asp Phe Val Ser Ile Asn Thr Ala Pro Cys Thr Leu

260 265 270His His Lys Phe Ala Val Ile Asp Asn Lys Thr Leu Leu Ala Gly Ser

275 280 285Ile Asn Trp Ser Lys Gly Arg Phe Ser Leu Asn Asp Glu Ser Leu Ile

290 295 300Ile Leu Glu Asn Leu Thr Lys Gln Gln Asn Gln Lys Leu Arg Met Ile305 310 315 320Trp Lys Asp Leu Ala Lys His Ser Glu His Pro Thr Val Asp Asp Glu

325 330 335Glu Lys Glu Ile Ile Glu Lys Ser Leu Pro Val Glu Glu Gln Glu Ala

340 345 350Ala<210>511<211>186<212>PRT<213>肺炎衣原体<400>511Met Ala Leu Asn Phe Lys Ile Asn Arg Gln Ile Arg Ala Pro Lys Val1 5 10 15Arg Leu Ile Gly Ser Ala Gly Glu Gln Leu Gly Ile Leu Ala Ile Lys

20 25 30Asp Ala Leu Asp Leu Ala Arg Glu Ala Gly Leu Asp Leu Val Glu Val

35 40 45Ala Ser Asn Ser Glu Pro Pro Val Cys Lys Ile Met Asp Tyr Gly Lys

50 55 60Tyr Arg Tyr Gly Leu Thr Lys Lys Glu Lys Asp Ser Lys Lys Ala Gln65 70 75 80His Gln Val Arg Ile Lys Glu Val Lys Leu Lys Pro Asn Ile Asp Glu

85 90 95Asn Asp Phe Ser Thr Lys Leu Lys Gln Ala Arg Thr Phe Val Glu Lys

100 105 110Gly Asn Lys Val Lys Ile Thr Cys Met Phe Arg Gly Arg Glu Leu Ala

115 120 125Tyr Pro Glu His Gly Phe Lys Val Val Gln Lys Met Ser Gln Gly Leu

130 135 140Glu Asp Ile Gly Phe Val Glu Ala Glu Pro Lys Leu Ala Gly Arg Ser145 150 155 160Leu Ile Cys Val Val Ala Pro Gly Thr Val Lys Thr Lys Lys Lys Gln

165 170 175Glu Lys Ser His Ala Gln Asp Glu Asn Gln

180 185<210>512<211>276<212>PRT<213>肺炎衣原体<220><221>VARIANT<222>269，270，271，272，274，275，276<223>Xaa＝任何氨基酸<400>512Met Gly Asn Ser Gly Phe Tyr Leu Gln Asp Thr Gln Asn Thr Ile Phe1 5 10 15Ala Asp Asn Ile Arg Leu Gly Gln Met Thr Thr Val Leu Lys Lys Asp

20 25 30Glu Val Ile Ile Gly Thr Asp Thr Thr Pro Thr Val Thr Lys Phe Ser

35 40 45Gly Asp Lys Gly Ile Val Ile Thr Thr Asp Ser Thr Ile Thr Pro Ser

50 55 60Ser Thr Thr Phe Ser Leu Asp Met Glu Ala Val Ile Lys Glu Val Thr65 70 75 80Asp Lys Ile Leu Thr Gln Ile Glu Asp Glu Leu Val Lys Asp Ile Ile

85 90 95Lys Asn Ile Thr Gln Ser Leu Ile Glu Glu Val Ile Lys Lys Ile His

100 105 110Ile Asp Pro Ser Phe Ser Tyr Ser Arg Ala Phe Lys Asp Val Asn Ile

115 120 125Thr Asn Lys Ile Gln Cys Asn Gly Leu Phe Thr Lys Glu Asn Ile Gly

130 135 140Asn Leu Asp Gly Gly Thr Glu Ile Ala Ser Ser Ser Val Thr Pro Asp145 150 155 160Asn Ala Asn Ser Met Phe Leu Ile Cys Ala Asp Ile Ile Ala Thr Arg

165 170 175Met Glu Gly Thr Val Ala Leu Ala Leu Val Lys Glu Gly Asp Leu Ser

180 185 190Pro Cys Ser Ile Ser Tyr Gly Tyr Ser Ala Gly Tyr Pro Asn Ile Ile

195 200 205Ser Leu Arg Ala Thr Val Gly Asn Lys Thr Thr Ala Pro Val Lys Phe

210 215 220Ser Leu Arg Ala Gly Gly Met Asp Ser Gly Val Val Trp Val Asn Ala225 230 235 240Met Pro Asn Gly Glu Lys Ile Leu Gly Val Asp Ala Val Ser Lys Ile

245 250 255Thr Ile Leu Glu Val Lys Pro Gln Thr Asn Gly Thr Xaa Xaa Xaa Xaa

260 265 270Phe Xaa Xaa Xaa

275<210>513<211>1044<212>PRT<213>肺炎衣原体<400>513Met Val Glu Val Glu Glu Lys His Tyr Thr Ile Val Lys Arg Asn Gly1 5 10 15Met Phe Val Pro Phe Asn Gln Asp Arg Ile Phe Gln Ala Leu Glu Ala

20 25 30Ala Phe Arg Asp Thr Arg Ser Leu Glu Thr Ser Ser Pro Leu Pro Lys

35 40 45Asp Leu Glu Glu Ser Ile Ala Gln Ile Thr His Lys Val Val Lys Glu

50 55 60Val Leu Ala Lys Ile Ser Glu Gly Gln Val Val Thr Val Glu Arg Ile65 70 75 80Gln Asp Leu Val Glu Ser Gln Leu Tyr Ile Ser Gly Leu Gln Asp Val

85 90 95Ala Arg Asp Tyr Ile Val Tyr Arg Asp Gln Arg Lys Ala Glu Arg Gly

100 105 110Asn Ser Ser Ser Ile Ile Ala Ile Ile Arg Arg Asp Gly Gly Ser Ala

115 120 125Lys Phe Asn Pro Met Lys Ile Ser Ala Ala Leu Glu Lys Ala Phe Arg

130 135 140Ala Thr Leu Gln Ile Asn Gly Met Thr Pro Pro Ala Thr Leu Ser Glu145 150 155 160Ile Asn Asp Leu Thr Leu Arg Ile Val Glu Asp Val Leu Ser Leu His

165 170 175Gly Glu Glu Ala Ile Asn Leu Glu Glu Ile Gln Asp Ile Val Glu Lys

180 185 190Gln Leu Met Val Ala Gly Tyr Tyr Asp Val Ala Lys Asn Tyr Ile Leu

195 200 205Tyr Arg Glu Ala Arg Ala Arg Ala Arg Ala Asn Lys Asp Gln Asp Gly

210 215 220Gln Glu Glu Phe Val Pro Gln Glu Glu Thr Tyr Val Val Gln Lys Glu225 230 235 240Asp Gly Thr Thr Tyr Leu Leu Arg Lys Thr Asp Leu Glu Lys Arg Phe

245 250 255Ser Trp Ala Cys Lys Arg Phe Pro Lys Thr Thr Asp Ser Gln Leu Leu

260 265 270Ala Asp Met Ala Phe Met Asn Leu Tyr Ser Gly Ile Lys Glu Asp Glu

275 280 285Val Thr Thr Ala Cys Ile Met Ala Ala Arg Ala Asn Ile Glu Arg Glu

290 295 300Pro Asp Tyr Ala Phe Ile Ala Ala Glu Leu Leu Thr Ser Ser Leu Tyr305 310 315 320Glu Glu Thr Leu Gly Cys Ser Ser Gln Asp Pro Asn Leu Ser Glu Ile

325 330 335His Lys Lys His Phe Lys Glu Tyr Ile Leu Asn Gly Glu Glu Tyr Arg

340 345 350Leu Asn Pro Gln Leu Lys Asp Tyr Asp Leu Asp Ala Leu Ser Glu Val

355 360 365Leu Asp Leu Ser Arg Asp Gln Gln Phe Ser Tyr Met Gly Val Gln Asn

370 375 380Leu Tyr Asp Arg Tyr Phe Asn Leu His Glu Gly Arg Arg Leu Glu Thr385 390 395 400Ala Gln Ile Phe Trp Met Arg Val Ser Met Gly Leu Ala Leu Asn Glu

405 410 415Gly Glu Gln Lys Asn Phe Trp Ala Ile Thr Phe Tyr Asn Leu Leu Ser

420 425 430Thr Phe Arg Tyr Thr Pro Ala Thr Pro Thr Leu Phe Asn Ser Gly Met

435 440 445Arg His Ser Gln Leu Ser Ser Cys Tyr Leu Ser Thr Val Lys Asp Asp

450 455 460Leu Ser His Ile Tyr Lys Val Ile Ser Asp Asn Ala Leu Leu Ser Lys465 470 475 480Trp Ala Gly Gly Ile Gly Asn Asp Trp Thr Asp Val Arg Ala Thr Gly

485 490 495Ala Val Ile Lys Gly Thr Asn Gly Lys Ser Gln Gly Val Ile Pro Phe

500 505 510Ile Lys Val Ala Asn Asp Thr Ala Ile Ala Val Asn Gln Gly Gly Lys

515 520 525Arg Lys Gly Ala Met Cys Val Tyr Leu Glu Asn Trp His Leu Asp Tyr

530 535 540Glu Asp Phe Leu Glu Leu Arg Lys Asn Thr Gly Asp Glu Arg Arg Arg545 550 555 560Thr His Asp Ile Asn Thr Ala Ser Trp Ile Pro Asp Leu Phe Phe Lys

565 570 575Arg Leu Glu Lys Lys Gly Met Trp Thr Leu Phe Ser Pro Asp Asp Val

580 585 590Pro Gly Leu His Glu Ala Tyr Gly Leu Glu Phe Glu Lys Leu Tyr Glu

595 600 605Glu Tyr Glu Arg Lys Val Glu Ser Gly Glu Ile Arg Leu Tyr Lys Lys

610 615 620Val Glu Ala Glu Val Leu Trp Arg Lys Met Leu Ser Met Leu Tyr Glu625 630 635 640Thr Gly His Pro Trp Ile Thr Phe Lys Asp Pro Ser Asn Ile Arg Ser

645 650 655Asn Gln Asp His Val Gly Val Val Arg Cys Ser Asn Leu Cys Thr Glu

660 665 670Ile Leu Leu Asn Cys Ser Glu Ser Glu Thr Ala Val Cys Asn Leu Gly

675 680 685Ser Ile Asn Leu Val Glu His Ile Arg Asn Asp Lys Leu Asp Glu Glu

690 695 700Lys Leu Lys Glu Thr Ile Ser Ile Ala Ile Arg Ile Leu Asp Asn Val705 710 715 720Ile Asp Leu Asn Phe Tyr Pro Thr Pro Glu Ala Lys Gln Ala Asn Leu

725 730 735Thr His Arg Ala Val Gly Leu Gly Val Met Gly Phe Gln Asp Val Leu

740 745 750Tyr Glu Leu Asn Ile Ser Tyr Ala Ser Gln Glu Ala Val Glu Phe Ser

755 760 765Asp Glu Cys Ser Glu Ile Ile Ala Tyr Tyr Ala Ile Leu Ala Ser Ser

770 775 780Leu Leu Ala Lys Glu Arg Gly Thr Tyr Ala Ser Tyr Ser Gly Ser Lys785 790 795 800Trp Asp Arg Gly Tyr Leu Pro Leu Asp Thr Ile Glu Leu Leu Lys Glu

805 810 815Thr Arg Gly Glu His Asn Val Leu Val Asp Thr Ser Ser Lys Lys Asp

820 825 830Trp Thr Pro Val Arg Asp Thr Ile Gln Lys Tyr Gly Met Arg Asn Ser

835 840 845Gln Val Met Ala Ile Ala Pro Thr Ala Thr Ile Ser Asn Ile Ile Gly

850 855 860Val Thr Gln Ser Ile Glu Pro Met Tyr Lys His Leu Phe Val Lys Ser865 870 875 880Asn Leu Ser Gly Glu Phe Thr Ile Pro Asn Thr Tyr Leu Ile Lys Lys

885 890 895Leu Lys Glu Leu Gly Leu Trp Asp Ala Glu Met Leu Asp Asp Leu Lys

900 905 910Tyr Phe Asp Gly Ser Leu Leu Glu Ile Glu Arg Ile Pro Asn His Leu

915 920 925Lys Lys Leu Phe Leu Thr Ala Phe Glu Ile Glu Pro Glu Trp Ile Ile

930 935 940Glu Cys Thr Ser Arg Arg Gln Lys Trp Ile Asp Met Gly Val Ser Leu945 950 955 960Asn Leu Tyr Leu Ala Glu Pro Asp Gly Lys Lys Leu Ser Asn Met Tyr

965 970 975Leu Thr Ala Trp Lys Lys Gly Leu Lys Thr Thr Tyr Tyr Leu Arg Ser

980 985 990Gln Ala Ala Thr Ser Val Glu Lys Ser Phe Ile Asp Ile Asn Lys Arg

995 1000 1005Gly Ile Gln Pro Arg Trp Met Lys Asn Lys Ser Ala Ser Thr Ser Ile

1010 1015 1020Val Val Glu Arg Lys Thr Thr Pro Val Cys Ser Met Glu Glu Gly Cys1025 1030 1035 1040Glu Ser Cys Gln<210>514<211>346<212>PRT<213>肺炎衣原体<400>514Met Glu Ala Asp Ile Leu Asp Gly Lys Leu Lys Arg Val Glu Val Ser1 5 10 15Lys Lys Gly Leu Val Asn Cys Asn Gln Val Asp Val Asn Gln Leu Val

20 25 30Pro Ile Lys Tyr Lys Trp Ala Trp Glu His Tyr Leu Asn Gly Cys Ala

35 40 45Asn Asn Trp Leu Pro Thr Glu Val Pro Met Ala Arg Asp Ile Glu Leu

50 55 60Trp Lys Ser Asp Glu Leu Ser Glu Asp Glu Arg Arg Val Ile Leu Leu65 70 75 80Asn Leu Gly Phe Phe Ser Thr Ala Glu Ser Leu Val Gly Asn Asn Ile

85 90 95Val Leu Ala Ile Phe Lys His Ile Thr Asn Pro Glu Ala Arg Gln Tyr

100 105 110Leu Leu Arg Gln Ala Phe Glu Glu Ala Val His Thr His Thr Phe Leu

115 120 125Tyr Ile Cys Glu Ser Leu Gly Leu Asp Glu Gly Glu Val Phe Asn Ala

130 135 140Tyr Asn Glu Arg Ala Ser Ile Arg Ala Lys Asp Asp Phe Gln Met Thr145 150 155 160Leu Thr Val Asp Val Leu Asp Pro Asn Phe Ser Val Gln Ser Ser Glu

165 170 175Gly Leu Gly Gln Phe Ile Lys Asn Leu Val Gly Tyr Tyr Ile Ile Met

180 185 190Glu Gly Ile Phe Phe Tyr Ser Gly Phe Val Met Ile Leu Ser Phe His

195 200 205Arg Gln Asn Lys Met Thr Gly Ile Gly Glu Gln Tyr Gln Tyr Ile Leu

210 215 220Arg Asp Glu Thr Ile His Leu Asn Phe Gly Ile Asp Leu Ile Asn Gly225 230 235 240Ile Lys Glu Glu Asn Pro Glu Val Trp Thr Thr Glu Leu Gln Glu Glu

245 250 255Ile Val Ala Leu Ile Glu Lys Ala Val Glu Leu Glu Ile Glu Tyr Ala

260 265 270Lys Asp Cys Leu Pro Arg Gly Ile Leu Gly Leu Arg Ser Ser Met Phe

275 280 285Ile Asp Tyr Val Arg His Ile Ala Asp Arg Arg Leu Glu Arg Ile Gly

290 295 300Leu Lys Pro Ile Tyr His Ser Arg Asn Pro Phe Pro Trp Met Ser Glu305 310 315 320Thr Met Asp Leu Asn Lys Glu Lys Asn Phe Phe Glu Thr Arg Val Thr

325 330 335Glu Tyr Gln Thr Ala Gly Asn Leu Ser Trp

340 345<210>515<211>327<212>PRT<213>肺炎衣原体<400>515Met Asp Ala Lys Met Gly Tyr Ile Phe Lys Val Met Arg Trp Ile Phe1 5 10 15Cys Phe Val Ala Cys Gly Ile Thr Phe Gly Cys Thr Asn Ser Gly Phe

20 25 30Gln Asn Ala Asn Ser Arg Pro Cys Ile Leu Ser Met Asn Arg Met Ile

35 40 45His Asp Cys Val Glu Arg Val Val Gly Asn Arg Leu Ala Thr Ala Val

50 55 60Leu Ile Lys Gly Ser Leu Asp Pro His Ala Tyr Glu Met Val Lys Gly65 70 75 80Asp Lys Asp Lys Ile Ala Gly Ser Ala Val Ile Phe Cys Asn Gly Leu

85 90 95Gly Leu Glu His Thr Leu Ser Leu Arg Lys His Leu Glu Asr Asn Pro

l00 105 110Asn Ser Val Lys Leu Gly Glu Arg Leu Ile Ala Arg Gly Ala Phe Val

115 120 125Pro Leu Glu Glu Asp Gly Ile Cys Asp Pro His Ile Trp Met Asp Leu

130 135 140Ser Ile Trp Lys Glu Ala Val Ile Glu Ile Thr Glu Val Leu Ile Glu145 150 155 160Lys Phe Pro Glu Trp Ser Ala Glu Phe Lys Ala Asn Ser Glu Glu Leu

165 170 175Val Cys Glu Met Ser Ile Leu Asp Ser Trp Ala Lys Gln Cys Leu Ser

180 185 190Thr Ile Pro Glu Asn Leu Arg Tyr Leu Val Ser Gly His Asn Ala Phe

195 200 205Ser Tyr Phe Thr Arg Arg Tyr Leu Ala Thr Pro Glu Glu Val Ala Ser

210 215 220Gly Ala Trp Arg Ser Arg Cys Ile Ser Pro Glu Gly Leu Ser Pro Glu225 230 235 240Ala Gln Ile Ser Val Arg Asp Ile Met Ala Val Val Asp Tyr Ile Asn

245 250 255Glu His Asp Val Ser Val Val Phe Pro Glu Asp Thr Leu Asn Gln Asp

260 265 270Ala Leu Lys Lys Ile Val Ser Ser Leu Lys Lys Ser His Leu Val Arg

275 280 285Leu Ala Gln Lys Pro Leu Tyr Ser Asp Asn Val Asp Asp Asn Tyr Phe

290 295 300Ser Thr Phe Lys His Asn Val Cys Leu Ile Thr Glu Glu Leu Gly Gly305 310 315 320Val Ala Leu Glu Cys Gln Arg

325<210>516<211>101<212>PRT<213>肺炎衣原体<400>516Met Asr Asn Arg Gln Asn Thr Asn Asp Phe Ile Arg Ile Val Lys Asp1 5 10 15Val Glu Lys Ala Phe Pro Glu Leu Asp Ile Lys Val Lys Ile Asp Lys

20 25 30Glu Lys Val Thr Phe Leu Thr Ser Pro Thr Glu Leu Tyr His Lys Ser

35 40 45Ile Ser Val Ile Leu Asn Leu Leu Asn Ser Ile Glu Ser Ser Leu Asp

50 55 60Leu Phe Pro Asp Ser Pro Val Val Glu Glu Leu Glu Lys Asn Asn Leu65 70 75 80Lys Leu Lys Lys Ala Leu Ile Met Leu Ile Leu Ser Arg Lys Asp Met

85 90 95Phe Ser Lys Thr Glu

100<210>517<211>261<212>PRT<213>肺炎衣原体<400>517Met Lys Thr Ile Ala Phe Cys Ser Phe Lys Gly Gly Thr Gly Lys Thr1 5 10 15Thr Leu Ser Leu Asn Val Gly Cys Asn Leu Ala Gln Tyr Ser Asn Lys

20 25 30Lys Val Leu Leu Val Asp Leu Asp Pro Gln Ala Asn Leu Thr Thr Gly

35 40 45Leu Gly Val Gln Ser Cys Tyr Glu Ser Asn Leu Asn Asp Ile Phe Arg

50 55 60Ser Ser Gly Asn Val Arg Asp Ile Ile Gln Asp Thr Lys Ile Glu Asn65 70 75 80Leu His Ile Val Pro Ser Ser Ile Leu Ile Glu Glu Phe Arg Glu Phe

85 90 95Asn Arg Asn Ser Val Leu Asp Thr Ser His Leu Arg Ser Ser Leu Gln

100 105 110Leu Ile Glu Ser Asn Tyr Asp Leu Cys Ile Leu Asp Thr Pro Pro Ser

115 120 125Leu Gly Thr Leu Thr Glu Glu Ala Phe Ile Ala Ser Asp His Leu Ile

130 135 140Val Cys Leu Thr Pro Glu Pro Phe Ser Ile Leu Gly Leu Gln Lys Ile145 150 155 160Lys Glu Phe Cys Ser Val Leu Pro Lys Lys Lys Asp Leu Ser Val Leu

165 170 175Gly Ile Val Phe Ser Phe Trp Asp Gly Arg Asn Ser Thr Asn Ser Thr

180 185 190Tyr Leu Asn Ile Ile Glu Ser Ile Tyr Glu Gly Lys Val Leu Ser Ser

195 200 205Lys Val Arg Arg Asp Ile Thr Leu Ser Arg Ser Leu Leu Lys Glu Thr

210 215 220Ser Ile Ala Asn Ala Tyr Pro Asn Ser Arg Ala Ser His Asp Ile Leu225 230 235 240Arg Leu Thr Lys Glu Ile Glu Asp Lys Leu Phe Asn Lys Glu Met Ser

245 250 255Ala Gln Glu Val Leu

260<210>518<211>526<212>PRT<213>肺炎衣原体<400>518Met Asn Val Leu Lys Tyr Thr Lys His Ser Pro Ser Ala His Ala Trp1 5 10 15Lys Leu Ile Gly Thr Ser Pro Lys His Gly Ile Tyr Leu Pro Leu Phe

20 25 30Ser Ile His Thr Lys Asn Ser Cys Gly Ile Gly Glu Phe Leu Asp Leu

35 40 45Ile Pro Leu Ile Ser Trp Cys Gln Lys Gln Gly Phe Ser Val Ile Gln

50 55 60Leu Leu Pro Leu Asn Asp Thr Gly Glu Asp Thr Ser Pro Tyr Asn Ser65 70 75 80Ile Ser Ser Val Ala Leu Asn Pro Leu Phe Leu Ser Leu Ser Ser Leu

85 90 95Pro Asn Ile Asp Thr Ile Pro Glu Val Ala Lys Lys Leu Gln Asp Met

100 105 110His Glu Leu Cys Ser Thr Pro Ser Val Ser Tyr Thr Gln Val Lys Glu

115 120 125Lys Lys Trp Ala Phe Leu Arg Glu Tyr Tyr Gln Lys Cys Cys Lys Ser

130 135 140Ser Leu Glu Gly Asn Ser Asn Phe Ser Glu Phe Leu Glu Ser Glu Arg145 150 155 160Tyr Trp Leu Tyr Pro Tyr Gly Thr Phe Arg Ala Ile Lys His His Met

165 170 175His Gly Glu Pro Ile Asn Asn Trp Pro Lys Ser Leu Thr Asp Gln Glu

180 185 190Asn Phe Pro Asp Leu Thr Lys Lys Phe His Asp Glu Val Leu Phe Phe

195 200 205Ser Tyr Leu Gln Phe Leu Cys Tyr Gln Gln Leu Cys Glu Val Lys Ala

210 215 220Tyr Ala Asp Gln His His Val Leu Leu Lys Gly Asp Leu Pro Ile Leu225 230 235 240Ile Ser Lys Asp Ser Cys Asp Val Trp Tyr Phe Arg Asp Tyr Phe Ser

245 250 255Ser Ser Arg Ser Val Gly Ala Pro Pro Asp Leu Tyr Asn Ser Glu Gly

260 265 270Gln Asn Trp His Leu Pro Ile Tyr Asn Phe Ser Gln Leu Ala Lys Asp

275 280 285Asp Tyr Ile Trp Trp Lys Glu Arg Leu Arg Tyr Ala Gln Asn Phe Tyr

290 295 300Ser Val Tyr Arg Leu Asp His Ile Ile Gly Phe Phe Arg Leu Trp Ile305 310 315 320Trp Asp Ser Ser Gly Arg Gly Arg Phe Ile Pro Asp Asn Pro Lys Asp

325 330 335Tyr Ile Lys Gln Gly Thr Glu Ile Leu Ser Thr Met Leu Gly Ala Ser

340 345 350Ser Met Leu Pro Ile Gly Glu Asp Leu Gly Ile Ile Pro Gln Asp Val

355 360 365Lys Thr Thr Leu Thr His Leu Gly Ile Cys Gly Thr Arg Ile Pro Arg

370 375 380Trp Glu Arg Asn Trp Glu Ser Asp Ser Ala Phe Ile Pro Leu Lys Asp385 390 395 400Tyr Asn Pro Leu Ser Val Thr Thr Leu Ser Thr His Asp Ser Asp Thr

405 410 415Phe Ala Gln Trp Trp Leu Asn Ser Pro Lys Glu Ala Lys Gln Phe Ala

420 425 430Lys Phe Leu His Leu Pro Phe Gln Lys Thr Leu Thr Thr Glu Thr Gln

435 440 445Ile Asp Ile Leu Lys Leu Ser His Glu Ser Ala Ser Ile Phe His Ile

450 455 460Asn Leu Phe Asn Asp Tyr Leu Ala Leu Cys Pro Asp Leu Val Ser Lys465 470 475 480Asn Leu Gln Arg Glu Arg Ile Asn Thr Pro Gly Thr Ile Ser Lys Lys

485 490 495Asn Trp Ser Tyr Arg Val Arg Pro Ser Leu Glu Glu Leu Ala Ile His

500 505 510Lys Lys Phe Asn Gly Tyr Ile Glu Lys Ile Leu Thr Gly Leu

515 520 525<210>519<211>147<212>PRT<213>肺炎衣原体<400>519Met Gln Asn Gln Tyr Glu Gln Leu Leu Glu Ser Leu Ala Pro Leu Leu1 5 10 15Asn Thr Thr Leu Ala Pro Asp Lys Asn Asn Ser Cys Leu Ile Arg Phe

20 25 30Ser Asp Thr His Val Pro Val Gln Ile Glu Glu Asp Gly Asn Ser Gly

35 40 45Asp Leu Ala Val Ser Thr Leu Leu Gly Thr Leu Pro Glu Asn Val Phe

50 55 60Arg Glu Arg Ile Phe Lys Ala Ala Leu Ser Val Asn Gly Ser Phe Gln65 70 75 80Ser Ser Ile Lys Gly Ile Leu Gly Tyr Gly Glu Val Thr Gln Gln Leu

85 90 95Tyr Leu Ser Asp Ile Leu Ser Met Asn Tyr Leu Asn Gly Glu Lys Leu

100 105 110Phe Glu Tyr Leu Lys Leu Phe Ser Leu His Ala Lys Ile Trp Met Glu

115 120 125Ser Leu Arg Thr Gly Asn Leu Pro Asp Leu His Val Leu Gly Ile Tyr

130 135 140Tyr Val Ala145<210>520<211>635<212>PRT<213>肺炎衣原体<400>520Met Ile Pro Phe Thr Lys Thr Ile Gly Phe Arg Leu Trp Leu Ala Cys1 5 10 15Ala Val Ala Ile Ile Ala Pro Leu Gly Ile Asn Ile Val Trp Leu Asn

20 25 30Leu Asp Gln Tyr Arg Thr Ile Val Ser Ala Ile Ser Thr Ala Leu Lys

35 40 45Glu Asn Ala Ala Phe Lys Ala Asn Thr Leu Thr Gln Ile Val Pro Leu

50 55 60Asn Val Asp Val Leu Ser Leu Phe Ser Asp Val Leu Asp Leu Asp Ala65 70 75 80Gly Ile Pro Glu Thr Pro Asn Val Leu Leu Ser Asn Glu Met Gln Lys

85 90 95Val Phe Gln Gly Ile Tyr Asn Glu Ile Ser Leu Ile Lys Val Phe Pro

100 105 110Asn Gly Asp Lys Ile Val Val Ala Ser Ser Ile Pro Glu His Leu Gly

115 120 125Glu Asn Tyr Asn His Lys Ile Asp Ile Pro Lys Asn Thr Pro Phe Leu

130 135 140Ala Ala Leu Lys Gln Ser Pro Lys Asn Gln Glu Val Phe Ser Val Met145 150 155 160Gln Ala Asn Val Phe Asp Ala Lys Thr Gln Glu Leu Gln Gly Ile Leu

165 170 175Tyr Thr Thr Phe Ser Ala Glu Ser Leu Leu Lys Asp Leu Leu Ile Asn

180 185 190Lys Gln Ser Tyr Leu Thr Val Lys Thr Ala Ile Leu Ser Lys Tyr Gly

195 200 205Val Ile Leu Lys Ala Ser Asp Pro Ala Leu His Leu His Thr Val Tyr

210 215 220Pro Asp Met Thr Lys Glu Lys Phe Cys Gln Val Phe Leu Asn Asp Asp225 230 235 240Pro Cys Pro Ile Asp Ser Glu Leu Gly Pro Leu Thr Leu Ser Pro Leu

245 250 255Asp Ile Gly Glu Asn Phe Tyr Ser Phe Lys Ile Lys Asp Thr Glu Ile

260 265 270Trp Gly Cys Ile Glu Asn Val Pro Ser Ile Asp Ile Ala Val Leu Ser

275 280 285Tyr Ala Lys Lys Glu Glu Ser Phe Ala Pro Leu Trp Arg Arg Ala Arg

290 295 300Met Tyr Thr Ala Tyr Phe Phe Cys Ile Leu Leu Gly Ser Leu Ile Ala305 310 315 320Phe Ile Val Ala Arg Arg Leu Ser Leu Pro Ile Arg Lys Leu Ala Thr

325 330 335Ala Met Ile Glu Ser Arg Lys Asn Lys Asn Cys Leu Tyr Thr Asp Asp

340 345 350Ser Leu Gly Phe Glu Ile Asn Arg Leu Gly His Ile Phe Asn Ala Met

355 360 365Val Glu Asn Leu His Lys Gln Gln His Leu Ala Lys Thr Asn Phe Glu

370 375 380Met Lys Glu Asn Ala Gln Asn Ala Leu His Leu Gly Glu Gln Ala Gln385 390 395 400Gln Arg Leu Leu Pro Asn Thr Leu Pro Ser Tyr Pro His Ile Glu Leu

405 410 415Ala Lys Ala Tyr Ile Pro Ala Ile Thr Val Gly Gly Asp Phe Phe Asp

420 425 430Val Phe Val Val Gly Glu Gly Ser Lys Ala Arg Leu Phe Leu Ile Val

435 440 445Ala Asp Ala Ser Gly Lys Gly Val Asn Ala Cys Gly Tyr Ser Leu Phe

450 455 460Leu Lys Asn Met Leu Arg Thr Phe Leu Ser Arg Ser Ser Ser Leu Gln465 470 475 480Gln Ala Ile Gln Glu Thr Ser Arg Leu Phe Tyr Asn Asn Thr Lys Asn

485 490 495Ser Gly Met Phe Val Thr Leu Cys Val Tyr Cys Tyr His Gln Thr Ser

500 505 510Asn Thr Met Glu Tyr Tyr Ser Cys Gly His Pro Pro Ala Cys Tyr Leu

515 520 525Asp Pro Asp Gly Glu Thr Ser Trp Leu Phe His Pro Gly Met Ala Leu

530 535 540Gly Phe Leu Pro Glu Val Ala Asn Ile Thr Ser Lys Leu Phe His Pro545 550 555 560Lys Pro Gly Ser Leu Phe Val Leu Tyr Ser Asp Gly Ile Thr Glu Ala

565 570 575His Asn Asn Asn Asn Asp Met Phe Gly Glu Glu Arg Leu Gln Ala Ala

580 585 590Ile Gln Gly Leu Thr Gly Lys Ser Ala Ala Asp Ala Val His Arg Leu

595 600 605Met Leu Ser Val Lys Thr Phe Val Gly Asn Ser His Gln His Asp Asp

610 615 620Ile Thr Leu Leu Ile Leu Lys Val Leu Glu Ser625 630 635<210>521<211>314<212>PRT<213>肺炎衣原体<400>521Met Phe Ser Tyr Ile Lys Asn Arg Ile Leu Phe Asn Leu Leu Ser Leu1 5 10 15Trp Ile Val Leu Thr Leu Thr Phe Leu Val Met Lys Thr Ile Pro Gly

20 25 30Asp Pro Phe Asn Asp Glu Gly Cys Asn Val Leu Ser Glu Glu Val Leu

35 40 45Gln Thr Leu Lys Ser Arg Tyr Gly Leu Asp Lys Pro Leu Tyr Gln Gln

50 55 60Tyr Thr Gln Tyr Leu His Ser Ile Ala Lys Leu Asp Phe Gly Asn Ser65 70 75 80Leu Val Tyr Lys Asp Arg Lys Val Thr Asn Ile Ile Ser Thr Ala Phe

85 90 95Pro Ile Ser Ala Ile Leu Gly Leu Gln Ser Leu Phe Leu Ser Ile Gly

100 105 110Gly Gly Ile Ala Leu Gly Thr Ile Ala Ala Leu Lys Lys Lys Lys Gln

115 120 125Arg Arg Tyr Ile Leu Gly Ala Ser Ile Leu Gln Ile Ser Ile Pro Ala

130 135 140Phe Ile Phe Ala Thr Leu Leu Gln Tyr Val Phe Ala Val Lys Ile Pro145 150 155 160Leu Leu Pro Ile Ala Cys Trp Gly Ser Phe Thr His Thr Ile Leu Pro

165 170 175Thr Leu Ala Leu Ala Val Thr Pro Met Ala Phe Ile Ile Gln Leu Thr

180 185 190Tyr Ser Ser Val Ser Ala Ala Leu Asn Lys Asp Tyr Val Leu Leu Ala

195 200 205Tyr Ala Lys Gly Leu Ser Pro Leu Lys Val Val Ile Lys His Ile Leu

210 215 220Pro Tyr Ala Ile Phe Pro Thr Ile Ser Tyr Ser Ala Phe Leu Thr Thr225 230 235 240Thr Val Ile Thr Gly Thr Phe Ala Ile Glu Asn Ile Phe Cys Ile Pro

245 250 255Gly Leu Gly Lys Trp Phe Ile Cys Ser Ile Lys Gln Arg Asp Tyr Pro

260 265 270Val Ala Leu Gly Leu Ser Val Phe Tyr Gly Thr Leu Phe Met Leu Ser

275 280 285Ser Leu Leu Ser Asp Leu Ile Gln Ser Ile Ile Asp Pro Gln Ile Arg

290 295 300Tyr Ala His Gly Lys Glu Lys Lys Arg Lys305 310<210>522<211>1240<212>PRT<213>肺炎衣原体<400>522Met Thr Trp Ile Pro Leu His Cys His Ser Gln Tyr Ser Val Leu Asp1 5 10 15Ala Met Ser Ser Ile Lys Asp Phe Val Ala Lys Gly Gln Glu Phe Gly

20 25 30Ile Pro Ala Leu Ala Leu Thr Asp His Gly Asn Leu Tyr Gly Ala Val

35 40 45Asp Phe Tyr Lys Glu Cys Thr Gln Lys Gly Ile Gln Pro Ile Ile Gly

50 55 60Cys Glu Cys Tyr Ile Ala Pro Gly Ser Arg Phe Asp Lys Lys Lys Glu65 70 75 80Lys Arg Ser Arg Ala Ala His His Leu Ile Leu Leu Cys Lys Asn Glu

85 90 95Gln Gly Tyr Arg Asn Leu Cys Ile Leu Thr Ser Leu Ala Phe Thr Glu

100 105 110Gly Phe Tyr Tyr Phe Pro Arg Ile Asp Lys Asp Leu Leu Arg Gln Tyr

115 120 125Ser Glu Gly Leu Ile Cys Leu Ser Gly Cys Leu Ser Ser Ser Val Ser

130 135 140Asp Ala Ala Leu Lys Ser Pro Glu Ala Leu Leu Leu Glu Leu Gln Trp145 150 155 160Phe Gln Asp Leu Phe Lys Asp Asp Tyr Phe Thr Glu Val Gln Leu His

165 170 175Lys Met Ser Glu Glu Ser Ile Ala Gly Phe Lys Glu Glu Trp Leu Lys

180 185 190Gln Glu Tyr Tyr Ser Leu Ile Glu Lys Gln Ile Lys Val Asn Thr Ala

195 200 205Val Leu Glu Ala Ser Lys Arg Leu Gly Ile Pro Thr Val Ala Thr Asn

210 215 220Asp Ile His Tyr Ile Asn Ala Asn Asp Trp Gln Ala His Glu Ile Leu225 230 235 240Leu Asn Val Gln Ser Gly Glu Thr Val Arg Ile Ala Lys Gln Asn Thr

245 250 255His Ile Pro Asn Pro Lys Arg Lys Val Tyr Arg Ser Arg Glu Tyr Tyr

260 265 270Phe Lys Ser Pro Ala Gln Met Ala Glu Leu Phe Lys Asp Ile Pro Glu

275 280 285Val Ile Ser Asn Thr Leu Glu Val Ala Lys Arg Cys Asp Phe Thr Phe

290 295 300Asp Phe Ser Lys Lys His Tyr Pro Ile Tyr Val Pro Glu Ser Leu Lys305 310 315 320Thr Leu Asn Ser Tyr Thr Glu Glu Asp Arg Tyr Gln Ala Ser Ala Val

325 330 335Phe Leu Lys Gln Leu Ala Glu Glu Ala Leu Pro Lys Lys Tyr Ser Ser

340 345 350Glu Val Leu Ala His Ile Ala Lys Lys Phe Pro His Arg Asp Pro Ile

355 360 365Asp Ile Val Lys Glu Arg Met Asp Met Glu Met Ala Ile Ile Ile Pro

370 375 380Lys Gly Met Cys Asp Tyr Leu Leu Ile Val Trp Asp Ile Ile His Trp385 390 395 400Ala Lys Ala Asn Gly Ile Pro Val Gly Pro Gly Arg Gly Ser Gly Ala

405 410 415Gly Ser Val Leu Leu Phe Leu Leu Gly Ile Thr Glu Ile Glu Pro Ile

420 425 430Arg Phe Asp Leu Phe Phe Glu Arg Phe Ile Asn Pro Glu Arg Leu Ser

435 440 445Tyr Pro Asp Ile Asp Ile Asp Ile Cys Met Ala Gly Arg Glu Arg Val

450 455 460Ile Asn Tyr Ala Ile Glu Arg His Gly Lys Asp Asn Val Ala Gln Ile465 470 475 480Ile Thr Phe Gly Thr Met Lys Ala Lys Met Ala Val Lys Asp Val Gly

485 490 495Arg Thr Leu Asp Met Ala Leu Ser Lys Val Asn His Ile Ala Lys His

500 505 510Ile Pro Asp Leu Asn Thr Thr Leu Ser Lys Ala Leu Glu Thr Asp Pro

515 520 525Asp Leu His Gln Leu Tyr Ile Asn Asp Ala Glu Ser Ala Gln Val Ile

530 535 540Asp Met Ala Leu Cys Leu Glu Gly Ser Ile Arg Asn Thr Gly Val His545 550 555 560Ala Ala Gly Val Ile Ile Cys Gly Asp Gln Leu Thr Asn His Ile Pro

565 570 575Ile Cys Ile Ser Lys Asp Ser Thr Met Ile Thr Thr Gln Tyr Ser Met

580 585 590Lys Pro Val Glu Ser Val Gly Met Leu Lys Val Asp Leu Leu Gly Leu

595 600 605Lys Thr Leu Thr Ser Ile Asn Ile Ala Met Ser Ala Ile Glu Lys Lys

610 615 620Thr Gly Gln Ser Leu Ala Met Ala Thr Leu Pro Leu Asp Asp Ala Thr625 630 635 640Thr Phe Ser Leu Leu His Gln Gly Lys Thr Met Gly Ile Phe Gln Met

645 650 655Glu Ser Lys Gly Met Gln Glu Leu Ala Lys Asn Leu Arg Pro Asp Leu

660 665 670Phe Glu Glu Ile Ile Ala Met Gly Ala Leu Tyr Arg Pro Gly Pro Met

675 680 685Asp Met Ile Pro Ser Phe Ile Asn Arg Lys His Gly Lys Glu Ile Ile

690 695 700Glu Tyr Asp His Pro Leu Met Glu Ser Ile Leu Lys Glu Thr Tyr Gly705 710 715 720Ile Met Val Tyr Gln Glu Gln Val Met Gln Ile Ala Gly Ala Leu Ala

725 730 735Ser Tyr Ser Leu Gly Glu Gly Asp Val Leu Arg Arg Ala Met Gly Lys

740 745 750Lys Asp Phe Gln Gln Met Glu Gln Glu Arg Glu Lys Phe Cys Lys Arg

755 760 765Ala Cys Asn Asn Gly Ile Asp Pro Glu Leu Ala Thr Val Ile Phe Asp

770 775 780Lys Met Glu Lys Phe Ala Ala Tyr Gly Phe Asn Lys Ser His Ala Ala785 790 795 800Ala Tyr Gly Leu Ile Thr Tyr Thr Thr Ala Tyr Leu Lys Ala Asn Tyr

805 810 815Pro Lys Glu Trp Leu Ala Ala Leu Leu Thr Cys Asp Ser Asp Asp Ile

820 825 830Glu Lys Ile Gly Lys Leu Ile Arg Glu Ala Gln Ser Met Gly Ile Pro

835 840 845Ile Leu Pro Pro His Ile Asn Val Ser Ser Asn His Phe Val Ala Thr

850 855 860Asp Glu Gly Ile Arg Phe Ala Met Gly Ala Ile Lys Gly Ile Gly Arg865 870 875 880Gly Leu Ile Glu Ser Ile Val Glu Glu Arg Asp His His Gly Pro Tyr

885 890 895Glu Ser Ile Arg Asp Phe Ile Gln Arg Ser Asp Leu Lys Lys Val Ser

900 905 910Lys Lys Ser Ile Glu Ser Leu Ile Asp Ala Gly Cys Phe Asp Cys Phe

915 920 925Asp Ser Asn Arg Asp Leu Leu Leu Ala Ser Val Glu Pro Leu Tyr Glu

930 935 940Ala Ile Ala Lys Asp Lys Lys Glu Ala Ala Ser Gly Val Met Thr Phe945 950 955 960Phe Thr Leu Gly Ala Met Asp Arg Lys Asn Glu Val Pro Ile Cys Leu

965 970 975Pro Lys Asp Ile Pro Thr Arg Ser Lys Lys Glu Leu Leu Lys Lys Glu

980 985 990Lys Glu Leu Leu Gly Ile Tyr Leu Thr Glu His Pro Met Asp Thr Val

995 1000 1005Arg Asp His Leu Ser Arg Leu Ser Val Val Leu Ala G1y Glu Phe Glu

1010 1015 1020Asn Leu Pro His Gly Ser Val Val Arg Thr Val Phe Ile Ile Asp Lys1025 1030 1035 1040Val Thr Thr Lys Ile Ser Ser Lys Ala Gln Lys Lys Phe Ala Val Leu

1045 1050 1055Arg Val Ser Asp Gly Ile Asp Ser Tyr Glu Leu Pro Ile Trp Pro Asp

1060 1065 1070Met Tyr Glu Glu Gln Gln Glu Leu Leu Glu Glu Asp Arg Leu Ile Tyr

1075 1080 1085Ala Ile Leu Val Leu Asp Lys Arg Ser Asp Ser Leu Arg Ile Ser Cys

1090 1095 1100Arg Trp Met Lys Asp Leu Ser Ile Val Asn Glu Asn Ile Ile Tyr Glu1105 1110 1115 1120Cys Asp Gln Ala Phe Asp Arg Ile Lys Asn Gln Val Gln Lys Met Ser

1125 1130 1135Phe Thr Met Ser Thr Ser Gly Lys Glu Thr Lys Ala Lys Gly Asn Lys

1140 1l45 1150Pro Asn Glu Asn Gly His Thr Gln Ala Leu Ala Pro Val Thr Leu Ser

1155 1160 1165Leu Asp Leu Asn Glu Leu Arg His Ser His Leu Cys Ile Leu Lys Lys

1170 1175 1180Ile Val Gln Lys His Pro Gly Ser Arg Thr Leu Val Leu Val Phe Thr1185 1190 1195 1200Gln Asp Asn Glu Arg Val Ala Ser Met Ser Pro Asp Asp Ala Tyr Phe

1205 1210 1215Val Cys Glu Asp Ile Glu Glu Leu Arg Gln Glu Leu Val Thr Ala Asp

1220 1225 1230Leu Pro Val Arg Val Ile Thr Val

1235 1240<210>523<211>576<212>PRT<213>肺炎衣原体<400>523Met Thr Asp Phe Pro Thr His Phe Lys Gly Pro Lys Leu Asn Pro Ile1 5 10 15Lys Val Asn Pro Asn Phe Phe Glu Arg Asn Pro Lys Val Ala Arg Val

20 25 30Leu Gln Ile Thr Ala Val Val Leu Gly Ile Ile Ala Leu Leu Ser Gly

35 40 45Ile Val Leu Ile Ile Gly Thr Pro Leu Gly Ala Pro Ile Ser Met Ile

50 55 60Leu Gly Gly Cys Leu Leu Ala Ser Gly Gly Ala Leu Phe Val Gly Gly65 70 75 80Thr Ile Ala Thr Ile Leu Gln Ala Arg Asn Ser Tyr Lys Lys Ala Val

85 90 95Asn Gln Lys Lys Leu Ser Glu Pro Leu Met Glu Arg Pro Glu Leu Lys

100 105 110Ala Leu Asp Tyr Ser Leu Asp Leu Lys Glu Val Trp Asp Leu His His

l15 120 125Ser Val Val Lys His Leu Lys Lys Leu Asp Leu Asn Leu Ser Lys Thr

130 135 140Gln Arg Glu Val Leu Asn Gln Ile Lys Ile Asp Asp Glu Gly Pro Ser145 150 155 160Leu Gly Glu Cys Ala Ala Met Ile Ser Glu Asn Tyr Asp Ala Cys Leu

165 170 175Lys Met Leu Ala Tyr Arg Glu Glu Leu Leu Lys Glu Gln Thr Gln Tyr

180 185 190Gln Glu Thr Arg Phe Asn Gln Asn Leu Thr His Arg Asn Lys Val Leu

195 200 205Leu Ser Ile Leu Ser Arg Ile Thr Asp Asn Ile Ser Lys Ala Gly Gly

210 215 220Val Phe Ser Leu Lys Phe Ser Thr Leu Ser Ser Arg Met Ser Arg Ile225 230 235 240His Thr Thr Thr Thr Val Ile Leu Ala Leu Ser Ala Val Val Ser Val

245 250 255Met Val Val Ala Ala Leu Ile Pro Gly Gly Ile Leu Ala Leu Pro Ile

260 265 270Leu Leu Ala Val Ala Ile Ser Ala Gly Val Ile Val Thr Gly Leu Ser

275 280 285Tyr Leu Val Arg Gln Ile Leu Ser Asn Thr Lys Arg Asn Arg Gln Asp

290 295 300Phe Tyr Lys Asp Phe Val Lys Asn Val Asp Ile Glu Leu Leu Asn Gln305 310 315 320Thr Val Thr Leu Gln Arg Phe Leu Phe Glu Met Leu Lys Gly Val Leu

325 330 335Lys Glu Glu Glu Glu Val Ser Leu Glu Gly Gln Asp Trp Tyr Thr Gln

340 345 350Tyr Ile Thr Asn Ala Pro Ile Glu Lys Arg Leu Ile Glu Glu Ile Arg

355 360 365Val Thr Tyr Lys Glu Ile Asp Ala Gln Thr Lys Lys Met Lys Thr Asp

370 375 380Leu Glu Phe Leu Glu Asn Glu Val Arg Ser Gly Arg Leu Ser Val Ala385 390 395 400Ser Pro Ser Glu Asp Pro Ser Glu Thr Pro Ile Phe Thr Gln Gly Lys

405 410 415Glu Phe Ala Lys Leu Arg Arg Gln Thr Ser Gln Asn Ile Ser Thr Ile

420 425 430Tyr Gly Pro Asp Asn Glu Asn Ile Asp Pro Glu Phe Ser Leu Pro Trp

435 440 445Met Pro Lys Lys Glu Glu Glu Ile Asp His Ser Leu Glu Pro Val Thr

450 455 460Lys Leu Glu Pro Gly Ser Arg Glu Glu Leu Leu Leu Val Glu Gly Val465 470 475 480Asn Pro Thr Leu Arg Glu Leu Asn Met Arg Ile Ala Leu Leu Gln Gln

485 490 495Gln Leu Ser Ser Val Arg Lys Trp Arg His Pro Arg Gly Glu His Tyr

500 505 510Gly Asn Val Ile Tyr Ser Asp Thr Glu Leu Asp Arg Ile Gln Met Leu

515 520 525Glu Gly Ala Phe Tyr Asn His Leu Arg Glu Ala Gln Glu Glu Ile Thr

530 535 540Gln Ser Leu Gly Asp Leu Val Asp Ile Gln Asn Arg Ile Leu Gly Ile545 550 555 560Ile Val Glu Gly Asp Ser Asp Ser Arg Thr Glu Glu Glu Pro Gln Glu

565 570 575<210>524<211>439<212>PRT<213>肺炎衣原体<220><221>VARIANT<222>428，429，430，431，432，433，434，435，437，438，439<223>Xaa＝任何氨基酸<400>524Ile Thr Ile Ala Val Asn Ser Thr Ser Gly Gly Leu Lys Ile Ser Gly1 5 10 15Asp Leu Lys Phe His Asn Asn Glu Gly Ser Phe Tyr Asp Asn Pro Gly

20 25 30Leu Lys Ala Asn Leu Asn Leu Pro Phe Leu Asp Leu Ser Ser Thr Ser

35 40 45Gly Thr Val Asn Leu Asp Asp Phe Asn Pro Ile Pro Ser Ser Met Ala

50 55 60Ala Pro Asp Tyr Gly Tyr Gln Gly Ser Trp Thr Leu Val Pro Lys Val65 70 75 80Gly Ala Gly Gly Lys Val Thr Leu Val Ala Glu Trp Gln Ala Leu Gly

85 90 95Tyr Thr Pro Lys Pro Glu Leu Arg Ala Thr Leu Val Pro Asn Ser Leu

100 105 110Trp Asn Ala Tyr Val Asn Ile His Ser Ile Gln Gln Glu Ile Ala Thr

115 120 125Ala Met Ser Asp Ala Pro Ser His Pro Gly Ile Trp Ile Gly Gly Ile

130 135 140Gly Asn Ala Phe His Gln Asp Lys Gln Lys Glu Asn Ala Gly Phe Arg145 150 155 160Leu Ile Ser Arg Gly Tyr Ile Val Gly Gly Ser Met Thr Thr Pro Gln

165 170 175Glu Tyr Thr Phe Ala Val Ala Phe Ser Gln Leu Phe Gly Lys Ser Lys

180 185 190Asp Tyr Val Val Ser Asp Ile Lys Ser Gln Val Tyr Ala Gly Ser Leu

195 200 205Cys Ala Gln Ser Ser Tyr Val Ile Pro Leu His Ser Ser Leu Arg Arg

210 215 220His Val Leu Ser Lys Val Leu Pro Glu Leu Pro Gly Glu Thr Pro Leu225 230 235 240Val Leu His Gly Gln Val Ser Tyr Gly Arg Asn His His Asn Met Thr

245 250 255Thr Lys Leu Ala Asn Asn Thr Gln Gly Lys Ser Asp Trp Asp Ser His

260 265 270Ser Phe Ala Val Glu Val Gly Gly Ser Leu Pro Val Asp Leu Asn Tyr

275 280 285Arg Tyr Leu Thr Ser Tyr Ser Pro Tyr Val Lys Leu Gln Val Val Ser

290 295 300Val Asn Gln Lys Gly Phe Gln Glu Val Ala Ala Asp Pro Arg Ile Phe305 310 315 320Asp Ala Ser His Leu Val Asn Val Ser Ile Pro Met Gly Leu Thr Phe

325 330 335Lys His Glu Ser Ala Lys Pro Pro Ser Ala Leu Leu Leu Thr Leu Gly

340 345 350Tyr Ala Val Asp Ala Tyr Arg Asp His Pro His Cys Leu Thr Ser Leu

355 360 365Thr Asn Gly Thr Ser Trp Ser Thr Phe Ala Thr Asn Leu Ser Arg Gln

370 375 380Ala Phe Phe Ala Glu Ala Ser Gly His Leu Lys Leu Leu His Gly Leu385 390 395 400Asp Cys Phe Ala Ser Gly Ser Cys Glu Leu Arg Ser Ser Ser Arg Ser

405 410 415Tyr Asn Ala Asn Cys Gly Thr Arg Tyr Ser Phe Xaa Xaa Xaa Xaa Xaa

420 425 430Xaa Xaa Xaa Phe Xaa Xaa Xaa

435<210>525<211>867<212>DNA<213>沙眼衣原体D血清变型<400>525atgacccatc agcataaaaa aatcagcgaa gaaacaatcg cctgtgacat gctagagcgc 60tataccggct ctaccgttca agagttccag ccctatctcc ttcttactaa ttttgcgtat 120tacgtggatg ttttcgctga aatctatcag gtccctgttt ctcgaggatc catgttttcg 180gcagcgcatg cgcctcaaat tcacacctca atcatcgatt ttaaattagg ctctccagga 240gcagctctta ccgtagatct gtgttctttc cttcccaatg ctacagcagc gatcatgttg 300ggcatgtgtg gaggcttaag atcccactac caaataggag attattttgt ccctgttgct 360agcatccgaa aagatggaac atcagatgca tacttccccc cagaggtccc tgcattagct 420aattttgtcg tacaaaaaat gatcaccaat attctcgaag ccaaaaacct cccttaccat 480ataggcatca cccacacgac taacattcgg ttttgggagt ttaataaaga gttccgtcga 540aaactatatg aaaataaagc tcaaactgtc gagatggagt gtgccacctt atttgctgca 600ggataccgaa ggaatcttcc tttaggagca cttttgctga tatcggatct acctttgcga 660aaagatggaa ttaaaactaa ggaaagcagt tcggcagtcc taaactctca caccaaagag 720catatactaa caggcgttga ggtgtttgcc tctctacaag agaaatcagg cccaggaatc 780aagaaaacaa aaggcttgcc gcacatggag tttgggcaag ccgatgattc tctttctgaa 840caaactgaag tttctggcgg ggatttc 867<210>526<211>1182<212>DNA<213>沙眼衣原体D血清变型<400>526atgtcaaaag aaacttttca acgtaataag cctcatatca acatagggac cattggccac 60gttgaccatg gtaagactac gttgacagct gctattacgc gtgcgttgtc tggagatggg 120ttggctgatt ttcgtgatta tagctctatt gacaacactc ctgaagaaaa agctcgcggt 180attacaatta acgcttccca cgttgagtac gaaacagcta atcgtcacta cgctcacgtg 240gactgccctg gtcacgctga ctatgttaaa aacatgatca ccggtgcagc tcaaatggac 300ggggctattc tagtagtttc tgcaacagac ggagctatgc ctcaaactaa agagcatatt 360cttttggcaa gacaagttgg ggttccttac atcgttgttt ttctcaataa aattgacatg 420atttccgaag aagacgctga attggtcgac ttagttgaga tggagttggt tgagcttctt 480gaagagaaag gatacaaagg gtgtccaatc atcagaggtt ctgctctgaa agctttggaa 540ggggatgctg catacataga gaaagttcga gagctaatgc aagccgtcga tgataacatc 600cctactccag aaagagaaat tgacaagcct ttcttaatgc ctattgagga cgtattctct 660atctccggac gaggaactgt agtaactgga cgtattgagc gtggaattgt taaagtttcc 720gataaagttc agttggtcgg tcttagagat actaaagaaa cgattgttac tggggttgaa 780atgttcagaa aagaactccc agaaggtcgt gcaggagaga acgttggatt gctcctcaga 840ggtattggta agaacgatgt ggaaagagga atggttgttt gcttgccaaa cagtgttaaa 900cctcatacac agttcaagtg tgctgtttac gttttgcaaa aagaagaagg tggacgacat 960aagcctttct tcacaggata tagacctcaa ttcttcttcc gtacaacaga cgtcacaggt 1020gtggtaactc tgcctgaggg aattgagatg gtcatgcctg gggataacgt tgagtttgaa 1080gtgcaattga ttagccctgt ggctttagaa gaaggtatga gatttgcgat tcgtgaaggt 1140ggtcgtacaa tcggtgctgg aactatttct aagatcattg ca 1182<210>527<211>1650<212>DNA<213>沙眼衣原体D血清变型<400>527gtggaatctt cccgtattct tattacttct gcgttgcctt acgcaaatgg tcctttgcat 60tttggacata ttaccggtgc ttatttgcct gcagatgttt atgcgcgttt tcagagacta 120caaggcaaag aggtcttgta tatttgtggt tctgatgaat acggaatcgc aattaccctt 180aatgcagagt tggcaggcat ggggtatcaa gaatatgtcg acatgtatca taagcttcat 240aaagatacct tcaagaaatt gggaatttct gtagatttct tttccagaac tacgaacact 300tatcatcctg ctattgtgca agatttctat cgaaacttgc aggaacgcgg actggtagag 360aatcaggtga ccgaacagct gtattctgag gaagaaggga agtttctagc ggaccgttat 420gttgtaggta cttgtcccaa gtgtgggttc gatcgagctc gaggagatga gtgtcagcag 480tgcggtgccg attacgaagc tagagatctg aaagagcctc gttctaaatt aacgggggca 540gctttatctt tacgtgatac ggaacatgct tacttgcatt tggagcgcat gaaagaagat 600ttgcttgctt tcgtgcaagg tatttatcta cgtcctcata tgcgtaattt cgttacggat 660tacatcgagc atttacgtcc tcgagcagtg actcgagatt tgtcttgggg aatacccgtt 720cctgatttgg aaaataaggt attctatgta tggttcgatg ctccaattgg ttacataagt 780ggaactatgg attgggcagc atcgattgga gaccctgaag cttggaagaa gttttggttg 840gacgatactg tgacctacgc acagtttata ggtaaagata atacttcttt ccatgcggct 900attttccctg ctatggaaat aggacaatct cttccctata agaaagtgga tgctcttgta 960acatcagaat ttttattgtt agaaggtttc cagttcagta aatcggatgg gaattttata 1020gacatggatg cgtttttaga aacgtattcc ttggataaac tgcgttatgt gttggcagcg 1080attgctccag agacttcgga tagcgaattc tctttccaag agttcaagac gcgatgcaat 1140tctgagcttg tagggaagta tggaaatttt gtgaatcgag ttctagcttt tgctgttaag 1200aatggatgca cagagctttc ttctcctcaa ttagagcaaa aggatttgga ttttatctca 1260aaatctcaaa aacttgctaa ggatgcagcc gaacattacg cacaatacag tttgcgtaag 1320gcgtgttcca cgattatgga attagctgct ttagggaatg gctatttcaa tgatgaagct 1380ccatggaaat tggctaaaga gggtaactgg aatcgggtac gcgctattct attctgtgct 1440tgttactgcc agaagttgct agctctcatt tcctatccta ttatgcctga aacagcattg 1500aagattttgg aaatgatagc tccacattcc ttagatctag gttcccaaga tccagataga 1560ttacaatctc tttggacaga ttcctttttt gattactcgg aagagaaatt ttctctgaaa 1620gagcctgaat tattgttcac aatggtagag 1650<210>528<211>300<212>DNA<213>沙眼衣原体D血清变型<400>528atggctagaa aagatcgttt aactaatgaa agactgaata agctatttga tagccccttt 60agtttggtta attacgtaat taagcaagct aagaacaaaa ttgctagagg agatgttcgt 120tcttctaatg tcgcgattga ggcgctgaac ttcctggatc tttatggcat tcagtccgaa 180tacgctgaaa gagatgatcg agagagacat ttgtctgcta caggagagag acgaagagaa 240caaggtttcg gaacatccag aagaaaagat ccttctctgt acaactggag cgacgtgaaa 300<210>529<211>615<212>DNA<213>沙眼衣原体D血清变型<400>529atgtcagtaa aggttatttc ccccttttct caagacgggg ttcaatgctt tcccaagctt 60tttatcatta gcgctcctgc tggagcaggg aagacaacac tcacccatat gctacaaaga 120gagtttcctg atgcatttga gaagacggtg tcgtcaacga cacgttcggc tcgtccaggc 180gaagtgcatg gcgtggatta tttgtttgta tctgaagatg actttaagca atctttagat 240agggaagatt ttttggaatg ggtcttttta tttgggactt attacggaac gagtaaggcg 300gagatttcta gagttctgca aaagggtaag cactgtatag ccgtgattga tgtacaagga 360gctttggctc tgaagaagca aatgccggca gtcactattt ttattcaagc tccctctcaa 420gaagaacttg agcgccgttt gaatgctcgg gattcagaga aagatttcca gaagaaagaa 480agattagagc atagcgctgt cgaaattgct gccgctagcg aatttgatta tgttgtggtt 540aatgatgatt tgattacagc atatcaagtt ttaagaagta tttttatagc tgaagaacat 600aggatgagtc atggc 615<210>530<211>1806<212>DNA<213>沙眼衣原体D血清变型<400>530ttgaaaccgt ataaaattga gaacattcgt aatttttcta tcattgctca tatcgaccac 60gggaaatcta cgatcgcaga tcgtttgtta gaaagtacta gtactatcga acaaagagag 120atgcgcgaac aacttttaga ttctatggat ctagaaagag aacgcgggat taccatcaaa 180gcgcatccgg tcactatgac ctatgaatac gaaggggaga cttacgaact caatctaata 240gatactcctg gacacgtaga tttctcttat gaagtatccc gatcactagc agcttgtgaa 300ggagcgctgc ttatagtaga tgctgcccaa ggtgttcaag ctcaaagctt agctaatgta 360tatctggctc tagaacgaga tttagaaatc attcctgttt taaataaaat agacttacct 420gctgctcaac cagaagctat aaaaaaacaa atcgaagagt tcatcggatt agatacttca 480aacaccattg cttgctcagc gaaaacaggt cagggtatcc ctgaaatttt agagtctatt 540atacgactcg ttcccccacc aaaacctcca caggaaacag aacttaaagc tttgatcttt 600gattctcact acgatcctta tgtaggaatc atggtttatg tacgcgtgat cagtggagaa 660atcaaaaagg gagatcgcat taccttcatg gcaaccaaag gctcctcttt tgaggtctta 720ggaataggag ctttcttacc ggaagctact ctcatggaag gatccttacg agccggacaa 780gtgggatact tcattgccaa cctaaaaaaa gtaaaggatg taaaaattgg cgatacagtc 840actactgtta aacatcctgc taaagagcct ttagaaggct ttaaagaaat caaacctgta 900gtgtttgctg gtatctatcc tatagattct tctgactttg ataccctgaa agatgctcta 960ggccggttgc agctaaacga ctcagctctt acgattgaac aagagaacag tcattctctc 1020ggatttgggt tccgctgtgg atttttagga ctgctgcact tagaaatcat ctttgagaga 1080atctctagag aatttgatct cgatattatt gctacagctc ctagcgttat ctacaaagtc 1140gtcttaaaaa atggtaaaac cctttttatt gataacccaa cagcatatcc tgacccagct 1200cttattgaac acatggagga gccttgggtc catgttaata tcattacgcc tcaagagtat 1260ctcagcaata ttatgagcct ttgtatggat aagcgtggga tctgtctaaa aacagatatg 1320cttgaccaac acagactggt gctttcatat gagctgcctc tcaatgagat tgtttctgat 1380ttcaatgata aactcaaatc tgtgacgaaa ggatacggct cctttgatta ccggttagga 1440gattataaaa agggtgctat cattaagctg gaaattctaa ttaatgatga ggctgttgat 1500gccttttcct gccttgtaca cagagacaaa gcagaatcaa aaggcagaag catctgcgag 1560aaactcgtag atgttatccc tcctcagctc tttaaaatcc ctattcaggc ggccatcaat 1620aaaaagatta ttgccagaga gacgattcga gctttagcga aaaatgtaac tgctaagtgc 1680tatggtggag atatcacaag aaaacgcaag ttgtgggaca aacagaaaaa agggaagaaa 1740cgaatgaaag aattcggaaa agtatccatt ccgaacacgg cgtttgttga agtccttaaa 1800atggag 1806<210>531<211>972<212>DNA<213>沙眼衣原体D血清变型<400>531gtggaactac ttcctcatga aaaacaggtt gtcgaatacg aaaaaacgat cgccgagttt 60aaagaaaaaa ataaagaaaa cagcctgctt tcttcttcag agattcaaaa attggataag 120cgtttagata gattaaaaga aaaaatttat tccgatctca ccccttggga aagagtacaa 180atttgtcgac atccttcgag acctagaaca gtgaattata tcgaaggaat gtgcgaagag 240tttgtagaac tttgtggaga tcgaacgttc cgagatgatc ctgcagttgt cggagggttc 300gcaaagattc aagggcagcg tttcatgctt atagggcaag aaaagggttg cgacacaaaa 360tctcgcatgc atcgtaactt cgggatgctt tgtcccgaag gctttagaaa ggctctacgc 420ttagctaaaa tggcagagaa attcggtttg ccaattatct ttctcgttga tacccctgga 480gctttccctg gattaacagc cgaagaaaga ggtcaaggtt gggctattgc gacaaactta 540tttgagttag ctagattagc taccccaatc attgtaattg tgattggtga aggatgttca 600ggaggcgctc taggaatggc tataggagat gttgtagcga tgctagaaca ctcgtattat 660tctgtaattt ctcctgaagg gtgtgcttct attttatgga aagatcctaa aaagaacagc 720gatgctgctg ccatgttaaa aatgcatgga gaggatctta agggatttgc tattgtggac 780gcagtgatca aagaacccat aggtggggct catcacaatc ctgcggccac atatcgtagt 840gttcaagaat atgtccttca agaatggctt aaattgaaag atttaccggt agaagagttg 900ctagaaaaac gatatcagaa attccgaacg ataggtctat atgaaacttc ttctgaaagc 960gattctgagg ca 972<210>532<211>1938<212>DNA<213>沙眼衣原体D血清变型<400>532atgaaacttc ttctgaaagc gattctgagg cataagaagc atttagtttt attcggtttt 60tctcttttat ccatattagg gctaacaata acgtctcaag cagaaatttt ttctctaggt 120cttattgcta agacaggtcc tgatacgttt cttctttttg ggaagcagga gggagcttcc 180ttagtcaaaa ggaaagagct gtccaaagat caacttcttg aacagtggga taatattgtt 240ggtgagggag acacgctatc tttgcctcaa gcgaatgctt atattgcgaa acattcagga 300ggctctcagt caataacaaa aaggctttcc gcctatctct ctggttgttt tgacttttct 360cgtttgcaat gcctcgcgct ttttctagta gttgttgcta ttttgaaatc aacaacgcta 420ttttttcaga ggtttttagc acaattaatt gctattcgtg tgagctgctc tttacgtaaa 480gattacttct tagctttaca aacgctcccg atgacattct ttcatgcaca cgatatgggg 540aatctaagta gtcgtgtgat agcagattca tctatgattg cattagctat taatgccctt 600atggtgaatt acattcaggc tcctatcact atgactttag ccttagtagt gtgcttgtct 660atttcttgga aattttgtgc ttgtgtttgt ttagcgttcc ctatttttat tttgccaatt 720gttatcattg caaagaaagt taaagcattg gctaaacgaa ttcaaaagag tcaagatcat 780tctgccgctg cgttattgga ttttctttta ggtattctta cagtaaaagt atttagaact 840gagcagtttt cttttagtaa gtattgtcag aaaaatgatg agattgctcg attggaagag 900cgcagtgctg cgtatagttt aattccaaga cctcttctgc acactattgc ctcgttgttc 960tttgctttgg tcattatgat cggtttgtat cattttcata tcccacctga ggagcttgtg 1020gtcttttgtg ggcttttgta tctcatttat gatccgatta aaaagtttgc tgatgaaaat 1080gcgaatatca tgtggggatg cgctgctgca gaacggtttt atgaagtatt ggatctagca 1140aagcagcagt ccaatgtttc tgaaaagtta aatgaattcc agggattaca acatagtatt 1200cagttttgca atgtatcctt tggatatgta gaggatagtc ccgtattatc ggatttcaac 1260ttagtattaa aaaaagggga ggctatcggt attgttggtc caacaggatc tgggaaatct 1320accatagcaa agttattgcc aaggctttat gaagtctctc atggcgaact gttaattgat 1380tcacttccga tacgaagcta ctgcaaaaat tctttaagga aacatattgg ttgtgtgctg 1440cagcatccat ttttattcta tgatacggtg tggaataacc tgacttgtgg cagaaccttt 1500tcagaagaag aagtatttca tgctttaaag caagctcatg cctacgaatt tgtttctaaa 1560atgcctcaag gcgtgcacag cttattagag gaatccagta aaaatttatc tggaggtcag 1620cagcaacgtt tgacaatagc tagagcattg ctgcataaca cctccattct gttgctagat 1680gaggcaacat cagcattgga tgccattagc gaaaattatg ttaaagagat agtcgggcag 1740ttaaaaggcc gttgtacaca aattatcatt gcccacaagc tctccactct cgaatacgta 1800gatcggattg tttacttgga acaagggaag aaaatagcag aaggaaccaa agaagagtta 1860ttagactctt gcccagcttt tcaaagaatg tgggtcttat cgggtgctaa ggactgggaa 1920ctcaatgctg tcgtaaaa 1938<210>533<211>1242<212>DNA<213>沙眼衣原体D血清变型<400>533atgttttctt cagcaattgt tattctaact gcaatttttg tcttgtgctc ggggtttgtt 60tctttatcgc atatagcttt attctcgctc ccttcttccc ttattgctca ttacagtcac 120tcaaaaaata ggcagctccg acaaattgcc aatcttatgg cctaccccaa tcatttgctc 180atgaccctag tcttcttcga catagggatt aatattggag tgcaaaactg catagcaacc 240ttagtaggcg attcggcatc tctattgctt accgtaggag ttcccctcgc tttgacacta 300gttttgggag aaattgtccc taaggttatc gcaatccctt acaatgcacg aattgcaaag 360attgtaaccc caatcatctt tgcctcaact aaaagcttcc gccctatatt tgattgggct 420atctcgggta tcaattttat cgttcagaaa atgttggccc gtcaagaaag tgattttatt 480caaccccaag aattaaaaga agtcctccga agctgtaaag atttcggagt tgtaaatcat 540gaggaaagtc gtcttctatt tggctatcta tccatggaag aaggtagcat taaagaacgc 600atgacgccca aacaagaaat cattttttat gatgtcctta ctccgattga aaatttatat 660aaactcttct ctggacctaa acaaagctat tccaaagttc tagtttgtaa aggtggtcta 720caaaatctct taggagtttg ttctgcaaaa ttgcttcttc tctacaaaga aaaattacaa 780tctgccgaag aactcttgcc tctccttcgt aaacctcact acattcctga aacagtatca 840gctaagacag ctttgtatca tctagcagga gaagactgtg gtttaggtat tatcattgat 900gaatatgggt ctatagaagg attgatcacc caaaatgatc tatttaaaat agtctctgat 960ggggtagctc ataatcgccc atcttttaaa caattcgctc actcagacaa gaatgttgtt 1020attgctgcag gcacctatga gctttctgat ttctatgacc tgtttggagt tgatcttcct 1080actacagcta attgcgttac cataggcgga tggctgacag aacaattagg agaaatccct 1140gaaacaggaa caaaattcgc ttggggacaa tttgtattcc aaatactaga cgcggctcct 1200aattgtgtga aacgggtgta tataaggaaa acccatggaa ac 1242<210>534<211>1212<212>DNA<213>沙眼衣原体D血清变型<400>534atggaaacta actctccctt tttctggtta ggagtgaacc tcctttgtat ttttgtccaa 60gggttctttt ccatgatgga aatggcttgc atatcattca atcgcgtgcg gttgcaatat 120taccttacga aaagcaataa aaaagcctct tacattaact tccttgttag aagaccttat 180cgcttatttg gaaccgtaat gttgggagta aatattgctt tgcaaatagg gtctgagtca 240tcacgaactt gttacaaact cctagggatt tctcctgaat atgctcctgc aacgcaaatt 300attttagtcg tcatttttgc tgaattaatt cctttagcta tctctcgtaa aattccagaa 360aaaatcgcct taaaaggagc ccctatcctc tatttcgctc actatctttt ctatccgctc 420atccaatgtg tcggtggcat taccaatatg atctacttta ttctgaatat taaggaagag 480acgctccact caacgcttag ccgagatgaa ttgcaaaaga cattagaaac tcatcatgaa 540gagcatgatt tcaatgtgat agctacaaat attttctctt taagcgcaac ttctgtagag 600caagtatgtc aatatttgga ccaaatcccg atactttcag ctaccgcttc cgtacgagat 660gtttgccagc tcgttcgtcg ccatcgttta gattttgtcc ctgtttacca taaagttaaa 720aagaatgtag tgggaatagc ttttccaaaa aacctcatta atcgaaatcc cagtgaccct 780gttgtccctt acctaagctc tccctggttc ataacagcta aatctaagct cattcatgcg 840atccaagaat tccgcaagaa tagttctaac gtcgccattg ttttaaataa taatggcgag 900cctatgggag ttttaggctt acatacggtg tttaaaacgt tattcaacac aagaaatatc 960gcccaattaa aacccaaacc aacttcttta attgaacgaa ctttctctgg gaacacacct 1020ttgtctgaaa tagaaaatga gctcgatatt atttttatgg ataatgattg tacaacaatt 1080gagcaactca tgttaaaact tctggatact cctccagaag taggcgcctc tatcattatc 1140aacgacctac tgttagaggt aaaagagatt tccttgtacg gcatcaaaac tgttgctatc 1200aaagatactc tg 1212<210>535<211>1617<212>DNA<213>沙眼衣原体D血清变型<400>535atgtgttgtg tggatggatc taattccatc caacaacgaa tgcgtttttg tgagtatcgt 60accgcagcgc aagaggctaa gacctcatta tcttccgatt gttccttact agaagctcgc 120ttggctttac gagccttagc caaacatcat gaatattctg cttggagaga ggccttcctc 180cgttctcaag aacgctttcc ttcattggaa gcagatcgtg atattcatga ggatcttgca 240gcttctcttc tacaaaaaaa tattagacat tcttcactta ccgttcgagt aattactatt 300ttagctgtag ggatggcgag agactatcgg ttagtgccta ttgttttgca ggctttgtct 360gatgatagcg ataccgtacg tgagattgct gtacaagtag ctgttatgta tggttctagt 420tgcttactgc gcgccgtggg cgatttagcg aaaaatgatt cttctattca agtacgcatc 480actgcttatc gtgctgcagc cgtgttggag atacaagatc ttgtgcctca tttacgagtt 540gtagtccaaa atacacaatt agatggaacg gaaagaagag aagcttggag atctttatgt 600gttcttactc ggcctcatag tggtgtatta actggcatag atcaagcttt aatgacctgt 660gagatgttaa aggaatatcc tgaaaagtgt acggaagaac agattcgtac attattggct 720gcagatcatc cagaagtgca ggtagctact ttacagatca ttctgagagg aggtagagta 780ttccggtcat cttctataat ggaatcggtt caaaagttag cttgtaattc actttctgct 840cgtgttcaga tgcaagctgc agccattctc tatttagaag gagatccttt cggagaagat 900aagcttacag aaggtttatc agctacttcc agcatccttt gtgaagctgc ctcagaagcg 960gtctgctcat tagggattca tggagttcat ttagctggac gttttttatc aaaagtacaa 1020ggaatgcgtt ctcgagtgaa tcttgctttc gcgcttttgg taagtcgaga gaaggtagaa 1080gaagctggag atgttgttgc ttcttttatt catagaatag agccctgtcg agctattgaa 1140cagtttttat gtgaagatca gaagattttt gtagcttcat ctcctctgca ggtagaaatc 1200atgaaaaggg atttggcgaa gaagatcatt cgtttattag ttgcagctca gtacagcaaa 1260gcaaaaatgg ttgtcgctca gtatttagca gggcagcagg tgggatggag tttctgttct 1320gaagtctttt gggaagaagg ggatagcgag gattttgttg aaccattaca agaagagagt 1380tttgcgtttg ccttagagaa agctctttct tttttgcaac gcgaaggagg agaagctggg 1440ttgcatgcag tgatcagttt atatccacat agtcgctggc aagacaagtt gactatcttg 1500gaagcaattg cttattcaga aaatagaatc gctacatgtt ttttaagaga gcgttgtctg 1560caggaagcgg cctctttaca atcggcagct gcaggagctg tattcgcctt attcaaa 1617<210>536<211>312<212>DNA<213>沙眼衣原体D血清变型<400>536atgcaaactt cccggatcag ctcttttttc cgagggcttg ttcacctgta ccgttgggcg 60atttctcctt ttctcggggc tccttgtcgc tttttcccta catgctctga gtacgctctt 120gttgcactaa agaaacatcc gctcagaaaa agcctttttc tcatcgccaa gcgcttactc 180aaatgcggcc cttggtgcat aggaggtatc gatctcgtcc ctagaacttc tgttgaagaa 240tatctcagtt cccctacccc tctagcagaa tccccagacg acaggactgt gccacacacc 300caagaaactt ct 312<210>537<211>1008<212>DNA<213>沙眼衣原体D血清变型<400>537atgcagcttt tttttggtag attttacgaa gtggcgtgta tagtagcaag tattttgagg 60gagagggatg taggagtttt tatggggata gaaggaagag gatcaggagc tatgcaaagt 120aaaaaaacga ttaaatggct gaagcaagct ctcgttctta gttctattgt gaatatccta 180ttactgcttt tgatttattc gaccgtattt agaaaagata tttataaatt acgggttttt 240ccagggaatc tcatcgctaa aagttcacga atagggaaga ttcctgaaga cattttggaa 300agactagaaa atgcttcgtt tgccgattta ttagccttgt tgcaggaaga gagaatggtt 360ttcggccatc cattaaaatc ttgggctcta ggggtgagca tccaaaaata ttttgtagat 420atcgctccta tgctgacgca tcctttaact tttattagac tcaaaagtcc tgaacgtact 480tggttacttc cggatattaa tgatcaggag tttacacgga tttgtcagta tttgcttaca 540gagaggttcc cattctcttc acgaggtttt tttcgtatta tggtgcgtga ttgtgaagca 600gggatggtgg atgaagatgt tctgtatcgg ttttgtcatc ttcctgagtt tctctatgtg 660cgttctctcc tttttggtgc ggaaatcgaa gctgcttcgg tcgcttctct ggcaagaatg 720attatccaag gaggggagga cttattcttt tccctgtgtt gtttagaaaa tcgtcaaacg 780gcgatttctg atcatcagag gcgctgtttt ctgaaagctt atgtggatag acaggaacct 840ttagcagctc ttctcttgtt agtacatgac gcggactggg tgttgcatga gttttctgat 900agcgatttac aatcctttat tcaacttttg cctagagagg cacactatac taagaagttt 960cttgggtgtg tggcacagtc ctgtcgtctg gggattctgc tagagggg 1008<210>538<211>1278<212>DNA<213>沙眼衣原体D血清变型<400>538atgtatgttc gctctatctt ttttagtatt atcgccttcc taacggtcgg atgctccttt 60tctcctccag aatcgggctt aatcatagcc attcacgatg atcctcgctc tctttctcca 120gaaaaaggag aaaatgcttt ccatttttct ttgtccaagg ctttatttgc tactctcttc 180agagaagagc tctctggatt aacccctgct ctggtctcct cctatcaagt ttcggaagac 240gggcggtttt atcgtttttg tattcgtaaa gatgctaagt ggagtgacgg ctctctttta 300cttgcagaag atgtaatagc tgcttgggaa cacactaaac aagctgggcg atattcccta 360ctttttgaaa agctatcttt tcgagcctct tcttcttcag aaatccttat tgaactcaaa 420gaacccgagc ctcaactatt ggcgatatta gcctctccgt tttttgctgt gtatcgtcca 480gaaaatcctt ttctttcttc tggacctttt atgccaaaaa cctatgtgca agggcaaacg 540ctcgttctac aaaaaaaccc ttattactat gaccatgcgc atgtggaatt acattccata 600gactttcgca tcattcccaa catttacaca gctctacacc tcttaagaag aggtgacgtg 660gattgggtgg ggcagccttg gcaccaaggg attccttttg agcttcggac tacctctgct 720ctctacaccc attactctgt agatggcaca ttctggctta ttcttaatcc caaagatcct 780gtactttcct ctctatctaa tcgtcagcga ttgattgctg ccgtccaaaa ggaaaaactg 840gtgaagcaag ctttaggaac acaatatcga gtagctgaaa gctctccatc tccagaggga 900atcatagctc atcaagaagc ttctactcct tttcctggga aaattacttt gatatatccc 960aataatatta cgcgctgtca gcgtttggcc gaggtattgc aagaacaatg ccgagacgca 1020ggtatccagc tgactcttga aggactcgaa taccatgtat ttgttcaaaa acgagccact 1080caagatttct ctgtctccac agcaacttct atagctttcc atccccttgc taaatctaag 1140ttcgatcaaa cggctctaga caatttcact tgtctgccct tgtaccacat agaatatgat 1200tatattttga gcagaccgct agatcaaatt gttcactatc cttcaggtag tgttgatttg 1260acctatgcac actttcac 1278<210>539<211>1815<212>DNA<213>沙眼衣原体D血清变型<400>539atgcaaaata ttcttcgaac ttcttcttgc agatatatgt ttttgctggg tattcgttcg 60gtgtggaatc gggtggctgt tgtgaataac tttagaggaa gttcatggaa aattgtagca 120atccccagtt gtatactgtt tactttgata ttccatttac ctagatggct gattgatttt 180ggggtatgta caaatttagc gtgctccttg tcgatcattt tttgggtgtt ttctctacgc 240tcttcagctt cggctcgtat tttcccttct ctccttttgt atctttgtct attgcgactt 300ggcctgaatt tagcctccac ccgatggatt ttatcttctg gatgggcttc tcctttaatt 360tttgcgttag ggaatttctt ttcccttggg agcatcccgg ttgctcttac ggtatgttta 420ctcctgtttt tagtgaattt tctcgtcata actaaaggag cagagcgtat tgcggaagtg 480cgagctcgtt tttcattaga agcgctccca ggtaaacaaa tgtctttaga tgctgatatt 540gctgctggaa ggatcgggta tagcagagcg tctgttaaaa aaagctctct tttagaagag 600agtgattact tctccgccat ggagggcgta ttccgctttg taaaaggcga tgcgataatg 660agttgggtgt tgttaggagt gaatatccta gctgctctgt ttttaggacg agctactcat 720gttggcgatt tgtggttaac tgtattaggc gatgctttag tgagtcaaat tccagcattg 780cttacatcgt gtgcagcagc aacgcttata gctaaagttg gggaaaaaga aagtctagcg 840cagcatctgc tagattatta tgagcagagt cgccagagtt ttctttttat cgctttgatc 900ctatgtggga tggcttgtat tccaggagct cctaaagctc tgatcctagg tttttcagtt 960ttattattct tagggtataa gaatccttct tcaggagaga ctcttctctt ccagaaagaa 1020cgggtagagt ttgtattgcc tgatgaggga gtgggaaatc ctgctaattt gtacaaggac 1080gcccgcaatc agatttatca agagttaggc gtagttttcc cggaagctat tgttgtacgt 1140catgtaacag gatcttctcc acgtttaatc ttttctgggc aagaggtcgc tttgagagag 1200ctgtcttgcc cagctatact agaatcgatt aggcagctag ctccagaaac gatcagtgaa 1260cgcttcgtta ctcgcttagt tgatgagttt cgagagcatg cattcttatc gatagaagag 1320atccttccgt taaaaatatc agagaattct ttgattttct tattgagagc tcttgttaga 1380gaacgagtgt ctttgcattt attccctaag attctcgaag ctatagatgt atatggctct 1440caaccaaaga attctcagga attggtagag tgtgtacgaa aatatcttgg gaagcaaatt 1500ggtttatcct tatggaatcg ccaagatgtc ttagaggtaa ttacgataga ctctctggtt 1560gagcagtttg tgagagattc acaagaaaag gttgtgttgg atttaaatga aaaagtagtt 1620gctcaggtga agcatttatt gcgggtaggg gaggggaatt ttcgagctat cgtaacggga 1680tccgaaacaa gaaaagaact gaaacgcata gtggatcctt atttcccaga tttattggtt 1740ttagcacata gcgaacttcc agaagagatc cctataactt tgttaggagc ggtgtctgat 1800gaggttttat tatca 1815<210>540<211>519<212>DNA<213>沙眼衣原体D血清变型<400>540atgaaaaagt tcttattact tagcttaatg tctttgtcat ctctacctac atttgcagct 60aattctacag gcacaattgg aatcgttaat ttacgtcgct gcctagaaga gtctgctctt 120gggaaaaaag aatctgctga attcgaaaag atgaaaaacc aattctctaa cagcatgggg 180aagatggagg aagaactgtc ttctatctat tccaagctcc aagacgacga ttacatggaa 240ggtctatccg agaccgcagc tgccgaatta agaaaaaaat tcgaagatct atctgcagaa 300tacaacacag ctcaagggca gtattaccaa atattaaacc aaagtaatct caagcgcatg 360caaaagatta tggaagaagt gaaaaaagct tctgaaactg tgcgtattca agaaggcttg 420tcagtccttc ttaacgaaga tattgtctta tctatcgata gttcggcaga taaaaccgat 480gctgttatta aagttcttga tgattctttt caaaataat 519<210>541<211>1062<212>DNA<213>沙眼衣原体D血清变型<400>541atgtctcaat ccacttattc tcttgaacaa ttagctgatt ttttgaaagt cgagtttcaa 60ggaaatggag ctactcttct ttccggagtt gaagagatcg aggaagcaaa aacggcacac 120atcacattct tagataatga aaagtatgct aaacatttaa aatcatcgga agctggcgct 180atcatcatat ctcgaacaca gtttcaaaaa tatcgagact tgaataaaaa ctttcttatc 240acttctgagt ctccttccct agtttttcaa aagtgtttag aattattcat tactcctgtt 300gactcaggat tcccaggtat tcatccgaca gccgttatcc atccaactgc gattattgaa 360gatcatgttt gtattgagcc ctatgctgta gtttgtcagc atgctcatgt tggatctgct 420tgccatattg ggtcaggtag cgtcattgga gcttattcaa ccgttggaga acactcttat 480atccatcctc gagtagttat tagagaacga gtctctattg ggaaacgagt aattattcaa 540ccaggagctg ttataggctc ttgtgggttc gggtatgtta ctagtgcttt tggacagcac 600aaacatttaa aacacctcgg gaaagtcatt attgaagacg acgtagagat cggcgcaaat 660acaactatcg acagaggccg gtttaaacac agtgttgtgc gtgaaggttc gaaaattgat 720aatcttgtgc aaattgccca tcaggtggag gtcggtcaac acagcatgat tgtagctcaa 780gctggaattg caggttctac aaagattggc aatcatgtaa ttatcggtgg acaagccggc 840ataaccggac atatttgcat tgcagatcat gtcattatga tggctcagac tggcgtcact 900aaatctatta cttctccagg gatctatggc ggagcgcctg ctcgtccata tcaagaaatt 960catcgccaag tagccaaagt acgcaacctt ccacgactcg aagaacgtat cgcagcactt 1020gagaaactag tccagaaatt agaagctctc tcagaacaac at 1062<210>542<211>1263<212>nNA<213>沙眼衣原体D血清变型<400>542atgactgcat caggaggagc tggagggcta ggcagcaccc aaacagtaga cgttgcgcga 60gcacaagctg ctgcagctac tcaagatgca caagaggtta tcggctctca ggaagcttct 120gaggcaagta tgctcaaagg atgtgaggat ctcataaatc ctgcagctgc aacccgaatc 180aaaaaaaaag gagagaagtt tgaatcatta gaagctcgtc gcaaaccaac agcggataaa 240gcagaaaaga aatccgagag cacagaggaa aaaggcgata ctcctcttga agatcgtttc 300acagaagatc tttccgaagt ctccggagaa gattttcgag gattgaaaaa ttcgttcgat 360gatgattctt ctcctgacga aattctcgat gcgctcacaa gtaaattttc tgatcccaca 420ataaaggatc tagctcttga ttatctaatt caaacagctc cctctgatgg gaaacttaag 480tccactctca ttcaggcaaa gcatcaactg atgagccaga atcctcaggc gattgttgga 540ggacgcaatg ttctgttagc ttcagaaacc tttgcttcca gagcaaatac atctccttca 600tcgcttcgct ccttatattt ccaagtaacc tcatccccct ctaattgcgc taatttacat 660caaatgcttg cttcttactt gccatcagag aaaaccgctg ttatggagtt tctagtaaat 720ggcatggtag cagatttaaa atcggagggc ccttccattc ctcctgcaaa attgcaagta 780tatatgacgg aactaagcaa tctccaagcc ttacactctg taaatagctt ttttgataga 840aatattggga acttggaaaa tagcttaaag catgaaggac atgcccctat tccatcctta 900acgacaggaa atttaactaa aaccttctta caattagtag aagataaatt cccttcctct 960tccaaagctc aaaaggcatt aaatgaactg gtaggcccag atactggtcc tcaaactgaa 1020gttttaaact tattcttccg cgctcttaat ggctgttcgc ctagaatatt ctctggagct 1080gaaaaaaaac agcagctggc atcggttatc acaaatacgc tagatgcgat aaatgcggat 1140aatgaggatt atcctaaacc aggtgacttc ccacgatctt ccttctctag tacgcctcct 1200catgctccag tacctcaatc tgagattcca acgtcaccta cctcaacaca gcctccatca 1260ccc 1263<210>543<211>693<212>DNA<213>沙眼衣原体D血清变型<400>543atgatggagg tgtttatgaa ttttttagat cagttagatt taattattca aaataagcat 60atgctagaac acacatttta tgtgaaatgg tcgaaggggg agcttactaa agagcaatta 120caggcgtatg ccaaagacta ttatttacat atcaaagcct ttcctaaata tttatctgcg 180attcatagtc gttgcgatga tttagaggcg cgtaagttat tgttagataa cttgatggat 240gaagagaacg gttaccctaa tcatattgat ttgtggaagc agtttgtgtt tgctctagga 300gttactccag aagagttaga ggctcatgag cctagtgaag cagcaaaagc gaaagtagct 360actttcatgc ggtggtgtac aggagattct ttagctgcag gagtggctgc tttgtattct 420tatgagagtc aaattccacg tatcgctaga gagaaaattc gtggattgac tgagtacttt 480ggattttcca atcctgaaga ctatgcatat ttcacagaac atgaagaagc ggatgtgcgg 540catgctagag aagaaaaagc gctcattgag atgcttctca aagatgacgc tgataaagtg 600ttagaggcat cgcaagaagt aacgcaatct ttgtatggct ttttagattc ttttttggat 660ccaggaactt gttgtagttg tcatcaatct tat 693<210>544<211>729<212>DNA<213>沙眼衣原体D血清变型<400>544atgaaaataa ctccgatcaa aacacgtaaa gtatttgcac atgattcgct tcaagagatc 60ttgcaagagg ctttgccgcc tctgcaagaa cggagtgtgg tagttgtctc ttcaaagatt 120gtgagtttat gtgaaggcgc tgtcgctgat gcaagaatgt gcaaagcaga gctgataaaa 180aaagaagcgg atgcttattt gttttgtgag aaaagcggga tatatctaac gaaaaaagaa 240ggtattttga ttccttctgc agggattgat gaatcgaata cggaccagcc ttttgtttta 300tatcctaaag atattttggg atcgtgtaat cgcatcggag aatggttaag aaattatttt 360cgagtgaaag agctaggcgt aatcattaca gatagccata ctactccaat gcggcgtgga 420gtactgggta tcgggctgtg ttggtatgga ttttctccat tacacaacta tataggatcg 480ctagattgtt tcggtcgtcc cttacagatg acgcaaagta atcttgtaga tgccttagca 540gttgcggctg ttgtttgtat gggagagggg aatgagcaaa caccgttagc ggtgatagag 600caggcaccta atatggtcta ccattcacat cctacttctc gagaagagta ttgttctttg 660cgcatagatg aaacagagga cttatacgga ccttttttgc aagcggttac gtggagtcaa 720gaaaagaaa 729<210>545<211>1149<212>DNA<213>沙眼衣原体D血清变型<400>545atgcttccac atcagcagaa cagcagttct gaacgtgccc gtcatcacga atctcgctca 60catcggcatt cctcatcatc aagacatcat gttacgcgat ctcaatcaag cgcactccct 120caattgcaag agcgtcctgt gcctcatcca cttgcagaaa gagaattgat tatattccat 180tccgtacatc agcagcagaa taataatcct ctaagaatga tttgcgatac cattcgccaa 240gctcaaagag ggatatttat gcgcatttac accatatcat ctgatgacat tatccaatct 300ctaattcaga cttcgcacca tgttcctgta gaagtcaaat accattgcgg agaaagctta 360cctgtagcat gtcaaaactc gagagtcgtc ttgcgtctga ctaacggaag aaccctccaa 420cataaaaaaa ctatgttggc tgatttccaa acagtagtta caggatcagc caactacacg 480gacttgtctc tcaatcacga tgccaacgtg acggcatgta tagaaagttc agaattacat 540gacgcagtct tttctgaaag accccaactg gttcatgtcg gacctcagct gctcaattac 600attcctatcc agcgtttgat tcctaatgca gcatcaaaaa tgattttgaa tgcaattaac 660caagcaacgg acagtatttt tgtcttgatg tatatcttct taagcccaga attcttctta 720gctcttgccc aagctatgcg aagaggagtt cgagtaaaag taatcatcga caaccattcc 780aaacaagata catgcaaact actgagcaaa ttgggtatcc aacttcctat ttacgaaaga 840aaaacggaag gcgttctcca tactaagatt tgttgcatcg acaataaaac tctaatcttt 900ggctctgcta actggagcgg tgctggtatg attaaaaact ttgaagacct attcatcctt 960cgcccaatta cagagacaca gcttcaggcc tttatggacg tctggtctct tctagaaaca 1020aatagctcct atctgtcccc agagagcgtg cttacggctc ctactccttc aagtagacct 1080actcaacaag atacagattc tgatgacgaa caaccgagta ccagccagca agatatccgt 1140atgagaaaa 1149<210>546<211>579<212>DNA<213>沙眼衣原体D血清变型<400>546ttgtggtttt ttttaggctc tccgtcagcg attactaatt ttagcagggt agatgtggct 60ttaaacctaa gaataaatag gcagatacga gctcctaggg tacgtgtaat aggttccgca 120ggagagcagc taggcatatt gagtataaaa gaggccctag atttagccaa ggaagctaat 180ttagaccttg ttgaggttgc ttcaaactca gagcctcccg tgtgcaaaat catggactat 240gggaagtatc gttacgacgt aactaaaaaa gaaaaagata gtaagaaagc acagcaccaa 300gtacgtatca aagaggttaa gcttaagcct aatatcgatg ataacgactt tcttacgaaa 360gcaaagcaag ctagagcctt tattgagaaa ggaaataaag taaaggtttc ttgtatgttt 420cgggggcgag agttggctta tcccgaacac gggtataagg ttattcaaag aatgtgtcag 480ggcttagagg acataggttt tgttgagtca gagcctaaac tgaatggccg ttctttgatc 540tgtgttattg ctccgggaac actaaaaact aagaaaaaa 579<210>547<211>3159<212>DNA<213>沙眼衣原体D血清变型<400>547atgtttacaa ggatagttat ggtcgatcta caagaaaagc aatgcacaat tgttaagcgc 60aatggaatgt ttgttccttt cgatcggaac cgtatttttc aggctttaga agcagctttt 120cgagacactc gcagaattga tgatcatatg cctttgcctg aagatctgga aagttccata 180cgctcgataa cgcatcaggt agttaaagaa gttgtgcaaa agattacaga tggacaagtg 240gttactgtag agcgtatcca agatatggtt gaaagccaac tatatgtgaa tggtttgcaa 300gatgttgctc gcgattatat tgtctatcgc gatgaccgta aagcgcatcg gaaaaaatct 360tggcaaagcc tatccgttgt tcgtcgttgt gggactgttg tacactttaa tcctatgaaa 420atttccgccg ctttggaaaa agctttccga gctaccgata agactgaggg gatgactcca 480agttctgtgc gagaggaaat caatgctttg acgcaaaaca ttgtcgcgga aatagaagaa 540tgttgtcctc aacaggatag acgcattgat atcgagaaga ttcaagatat tgttgaacag 600caactaatgg ttgttgggca ttatgctgtt gcaaagaact atattcttta tcgagaagct 660cgcgctcgtg ttcgtgataa cagagaagag gacgggagta cagaaaagac tatagcagaa 720gaagctgttg aggtgctcag taaagacggt tctacctata caatgacgca ttcgcagttg 780ttggctcatt tagcgcgcgc ttgtagtcgt tttccagaaa cgacagatgc ggcgctgctt 840accgatatgg ctttcgcaaa tttctattcc ggtatcaaag agtctgaagt agtactggcc 900tgtattatgg cggctcgtgc caatattgaa aaggagcctg attatgcctt tgttgctgca 960gagctcttac ttgacgttgt atataaggaa gcgttaggga aatcgaaata tgctgaggat 1020ttagaacaag cacatcgcga tcatttcaaa cgctacatcg cagaagggga tacctatcgt 1080ctgaatgctg aactgaaaca tctttttgat ttagacgcgt tagccgatgc tatggatcta 1140tctcgagatc tacagttttc ttacatgggt attcaaaatc tgtatgatcg ttattttaat 1200caccacgaag gttgccgttt agaaactccc caaatttttt ggatgcgcgt tgctatgggg 1260ttggcattga atgagcaaga caagacttct tgggctatta ctttttataa tttgctttcg 1320acattccgat atacaccagc tacgccaacc ttgttcaatt caggtatgcg gcattctcag 1380ttaagctctt gctatctttc cactgtacaa gataatttgg tcaatatcta taaggtcatt 1440gctgataacg ctatgctatc taagtgggca ggagggatag gtaatgattg gacggcgatt 1500cgtgcaacag gggctttaat taaaggaacc aatggaagaa gtcagggagt aattcctttt 1560attaaggtga caaatgatac agcagtcgca gtgaatcaag gtggtaaacg caagggagct 1620gtatgcgtct atttagaagt ttggcacctc gactacgaag atttccttga attgagaaag 1680aatacagggg atgagcgtcg acgggctcat gatgtcaata tagctagctg gattccagat 1740cttttcttca aacgtttaca gcaaaaaggg acatggactc tattcagccc agatgatgtt 1800ccgggattac acgatgctta tggggaagaa tttgagcgtt tgtacgaaga atatgagcgg 1860aaggttgata ccggagagat tcggttattc aagaaggtag aagctgaaga tctgtggaga 1920aaaatgctca gcatgctttt tgaaacggga cacccatgga tgacttttaa agatccatcc 1980aacatccgtt cggctcaaga tcataaaggc gtggtgcgtt gttccaatct gtgtacggag 2040attttgttaa actgctcgga gacagaaact gctgtttgta atttaggatc gattaactta 2100gttcaacata tcgtagggga tgggttagat gaggaaaaac tctctgagac gatctctata 2160gcagtccgta tgttggataa cgtgattgat attaactttt atccaacaaa ggaagctaaa 2220gaggcgaact ttgctcaccg cgctattgga ttaggggtga tgggattcca agatgccttg 2280tataagctag atataagcta tgcttcgcaa gaagctgtag aatttgctga ctacagttca 2340gagttgattt cttactatgc gattcaagct tcttgtctgc tcgctaaaga acgaggcact 2400tacagctctt ataaaggatc gaaatgggat agaggtttgc tccctattga tacgattcag 2460ttgttagcga actatcgagg agaagcaaat ctccagatgg atacgtcatc aagaaaagat 2520tgggaaccta tccgtagttt ggttaaagag catggtatgc gacattgtca gcttatggct 2580atagctccga cagcgacgat ctccaacatt ataggagtaa ctcaatctat tgagccaacg 2640tacaaacatt tgtttgtgaa gtctaatttg tccggagaat tcacgattcc aaatgtgtat 2700ttaattgaga agttgaagaa attaggtatc tgggatgctg atatgttaga tgacctgaaa 2760tattttgatg ggtctttatt ggaaatcgag cgtataccag atcacttaaa acatattttc 2820ttgacagctt ttgagattga accagaatgg attatcgaat gcgcgtctcg aagacaaaaa 2880tggattgata tggggcaatc cctcaacctt tatcttgccc agccagacgg gaaaaaactg 2940tcgaatatgt atttaacggc ttggaaaaaa ggtttgaaaa ctacgtatta tctgagatct 3000tcatcagcaa cgaccgttga aaaatctttt gtagatatta ataagagagg aattcagcct 3060cgttggatga agaataagtc tgcttcggca ggaattattg ttgaaagagc gaagaaagca 3120cctgtctgtt ctttggaaga agggtgtgaa gcatgtcag 3159<210>548<211>1038<212>DNA<213>沙眼衣原体D血清变型<400>548atgcaagcag atattttaga tggaaaacag aaacgcgtta atctaaatag caagcgtcta 60gtgaactgca accaggtcga tgtcaaccaa cttgttccta ttaagtacaa atgggcttgg 120gaacattatt tgaatggctg cgcaaataac tggctcccta cagagatccc catggggaaa 180gacatcgaat tatggaagtc ggatcgtctt tctgaagatg agcggcgagt cattcttttg 240aatttaggtt ttttcagcac cgcagagagc ttggttggga ataatattgt tctagcaatt 300tttaaacatg taactaatcc ggaagcgaga caatatcttt taagacaagc ttttgaagaa 360gcggttcaca cgcacacatt tttgtatatt tgtgagtcac tcggattaga cgagaaagaa 420attttcaatg cctataacga gcgtgctgcg attaaggcca aagatgattt ccagatggaa 480atcactggca aggtattaga tcctaatttt cgcacggact ctgttgaggg tctacaggag 540tttgttaaaa acttagtagg atactacatc attatggaag ggattttctt ctatagtggg 600tttgtgatga tcctttcctt ccacagacaa aataagatga ttggtattgg agaacaatat 660caatacatct taagagatga gacaatccac ttgaactttg gtattgattt gatcaacggg 720ataaaagaag agaacccgga gatttggact ccagagttac agcaagaaat tgtcgaatta 780attaagcgag ctgtcgattt agaaattgag tatgcgcaag actgtctccc tagagggatt 840ttgggattga gagcttcgat gttcatcgat tatgtgcagc atattgcaga ccgtcgtttg 900gaaagaatcg gattaaaacc tatttatcat acgaaaaacc cattcccttg gatgagcgaa 960acaatagacc ttaataaaga gaaaaacttc tttgaaacaa gggttataga atatcaacat 1020gcagcaagct taacttgg 1038<210>549<211>978<212>DNA<213>沙眼衣原体D血清变型<400>549atgtcttttt ttcatactag aaaatataag cttatcctca gaggactctt gtgtttagca 60ggctgtttct taatgaacag ctgttcctct agtcgaggaa atcaacccgc tgatgaaagc 120atctatgtct tgtctatgaa tcgcatgatt tgtgattgcg tgtctcgcat aactggggat 180cgagtcaaga atattgttct gattgatgga gcgattgatc ctcattcata tgagatggtg 240aagggggatg aagaccgaat ggctatgagc cagctgattt tttgcaatgg tttaggttta 300gagcattcag ctagtttacg taaacattta gagggtaacc caaaagtcgt tgatttaggt 360caacgtttgc ttaacaaaaa ctgttttgat cttctgagtg aagaaggatt ccctgaccca 420catatttgga cggatatgag agtatggggt gctgctgtaa aagagatggc tgcggcatta 480attcaacaat ttcctcaata tgaagaagat tttcaaaaga atgcggatca gatcttatca 540gagatggagg aacttgatcg ttgggcagcg cgttctctct ctacgattcc tgaaaaaaat 600cgctatttag tcacaggcca caatgcgttc agttacttta ctcgtcggta tctatcctct 660gatgcggaga gagtgtctgg ggagtggaga tcgcgttgca tttctccaga agggttgtct 720cctgaggctc agattagtat ccgagatatt atgcgtgtag tggagtatat ctctgcaaac 780gatgtagaag ttgtcttttt agaggatacc ttaaatcaag atgctttgag aaagattgtt 840tcttgctcta agagcggaca aaagattcgt ctcgctaagt ctcctttata tagcgataat 900gtctgtgata actattttag cacgttccag cacaatgttc gcacaattac agaagaattg 960ggagggactg ttcttgaa 978<210>550<211>438<212>DNA<213>沙眼衣原体D血清变型<400>550atgcaaaatc aatttgaaca actccttact gaattaggga ctcaaatcaa cagccctctt 60actcctgatt ccaataatgc ctgtatagtt cgctttggat acaacaatgt tgctgtacaa 120attgaagagg atggtaattc aggattttta gttgctggag tcatgcttgg aaaacttcca 180gagaatacct ttagacaaaa aattttcaaa gctgctttgt ctatcaatgg atctccgcaa 240tctaatatta aaggcactct aggatacggt gaaatctcta accaactcta tctctgtgat 300cggcttaaca tgacctatct aaatggagaa aagctcgccc gttacttagt tcttttttcg 360cagcatgcca atatctggat gcaatctatc tcaaaaggag cacttccaga tttacatgct 420ctaggtatgt atcacctg 438<210>551<211>1581<212>DNA<213>沙眼衣原体D血清变型<400>551atgccgtcat tatcccaatc ccgacgtatc atccagcaat cttccattcg aaagatttgg 60aatcagatag atacttctcc taagcatggc gtatgcgtac cgttattttc tctctatact 120caagaaagtt gtgggatagg tgaatttctt gacctgattc ctatgatcga ttggtgtatc 180tcgtgtggtt ttcaaatcct tcaaattctt ccgattaacg atacagggtc ctgttcgagt 240ccttacaata gcatttcttc gatagcactc aatcctcttc acctttctat ctctgcgctc 300ccctataaag aagaagtgcc agctgcggaa acacgcatac gagaaatgca gcaactctct 360caacttcctc aagtacatta tgaaaaagtt cgctctatga agagagattt ttttcaagag 420tactaccgcg tgtgtaaaca gaaaaaactc actgatcatc ctgattttta tgccttctgt 480gaacaggaaa aatattggtt acatccctac gctctctttc gctctatccg agaacatttg 540gataaccttc ctattaatca ttggccaacc acctacacag atctctccca gattaccgag 600catgaacgta cttttgcgga agatatacaa tttcactctt atctacagta tttgtgcttc 660caacagatga cacaagtgcg ggagcatgcc aattgcaaaa gctgtctcat caaaggggat 720atccctattc taatcagtaa agatagctgc gatgtctggt tttataggca ttacttttcc 780tcttcagaat ctgtaggtgc tcctcctgac ctgtataatg cggaaggtca gaactggcat 840ctccccattt gtaatatgaa aactttgcaa caagataact acctctggtg gaaggagcgc 900ttacgttatg cggagaattt ttactcttta taccgtcttg atcatgtcgt cggtctcttt 960cgattttggg tatgggatga gtctggatgc ggacgctttg aacctcatga tccgaaaaac 1020tatctagctc aagggcaaga tatcttatct cacctcttga ccagttcatc tatgctacct 1080ataggagaag atctgggaac gatcccttcc gatgtgaaac gtatgctcga gtcttttgcc 1140gtatgcggca ctagaattcc tcgttgggaa cgaaactggg aggggaatgg agcctatacc 1200cctttcgatc aatacgaccc tctatccgtc acaagcctct ctactcatga ttcctctaca 1260ttagcctcat ggtggaaaga atctcctcag gaatccaaac tatttgctca gtttttagga 1320ctcccctatt cttccaccct atctcttcac aatcataccg aaatcctgaa actctctcac 1380aaaacctctt ctatttttcg catcaatctt attaatgact atctggctct gttcccggat 1440ttgatatcaa aaactcctcg ctacgaaaga atcaatctgc caggaactat ttcaaaaaat 1500aattgggtgt atcgagttaa gccttctatt gaagatttat cctctcattc taagctaaat 1560tctttacttg aggctctatt t 1581<210>552<211>1950<212>DNA<213>沙眼衣原体D血清变型<400>552atgaccatcc ctattcatga gaataaatat tccatgatct ccttcacacg cacgataggt 60tttcgtttat ggcttatctg tgtggccgct attatgttcc ccttagggat caatatcttg 120caattgaacc ttcagcaata caagaaaaca ctctcctcta tcacttccga tctgcgagaa 180aatgctttat ttaaagctca cactttacaa caaactattc ctttaaatat tgatatcctg 240gctctctttt cagaaatttt tgatctagac agaggagtcc ctgctgaacc ggatcttgct 300ctaagtaaag aaatggagaa gatctttcac tccacttata aagagatttc tctagtaaaa 360aaagaggctg atgggaactt tagagtcgtt gcttctagcc gcatcgaaca acttggtaaa 420aactataacc aagagatttt cctatcagat tctcaaccat ttctcgctac tttgcgacat 480tccggttccg attctcaggt tctggctgtc ttacaaacga atatttttga tatcagctct 540caagaagtcc ttggcgtact ctataccctt tcggatacca actatttatt aaatggatta 600cttgcagcta aagatcctct ctccgtaaaa actgcaattc tctct aaaa tggcatcatt 660cttcaagcaa cagattcctc tttagatctt gtatcgatac acaaaacggt ttctaaagag 720caattttgtg atgttttcct tcgcgatgat atctgccccc ctcatctctt actacgcccc 780cctttaaatc tcgatcctct tccttatggc gagaatttcg tttcattttg cattgggaac 840acagaaatgt ggggatatat ccactctcta cctgagatgg atttccgtat attgacttat 900gaagaaaaat ctataatttt tgcttcttta tggcgacgaa ccttactgta ctttgcttat 960ttttgttgcg tacttttagg aagcattaca gcttttttag ttgcaaaacg cctatccaag 1020cctatccgga agctggctac ggccatgatg gaaactcgtc gcaatcaaca ccatccatat 1080gaacccgatt ctctgggctt tgaaattaat catctaggag aaatctttaa ctccatggtg 1140caaagccttt tgcaacagca atctttagca gaaaaaaatt tcgagatcaa acagcatgca 1200caaaatgcat tacgactagg agaagaagct caacaatgcc tgcttcctaa ccagctgcct 1260gattccccaa ctacagaaat cgctaaagcc tatattcctg caattacggt aggaggagat 1320ttctttgata tctttgttat aggcgaaggt ccccaagcta aactctttct aatcgttgct 1380gatgcttccg ggaaaggagt caatgcgtgc gcctactcct tattcctgaa aaacatgtta 1440catacctttt tgagtgagct ctcctctatt caagaagccg ttcaacaaac agctgctctc 1500ttctatcaac agacagctga atctgggatg tttgtaacac tatgcattta ttgttatcat 1560tacgcaacac gagaactaga atactattct tgtggccaca acccagcgtg tctccgagct 1620cctaatggag atatctcttt cctgtcgcat cctggtatgg ccttaggatt tttacctgaa 1680gttcctcctc accctgctta cactctcgtt cttgaagagg agtctctttt agtgctctat 1740accgatgggg tgactgaagc aagcaataag catggagaga tgtttggaga agaacgctta 1800aaagcattag tggcttcgtt gacgaaacaa agtgccgaag aagccatcca atctatcatg 1860ttctctatta agtcttttgt gaaagattgc ccacaacatg acgatatcac tttactcgtt 1920ttgaaaatac ctaaggaacc ttccgcttat 1950<210>553<211>939<212>DNA<213>沙眼衣原体D血清变型<400>553atgctcagct acataaagag gcggctgttg tttaatttgc tttctttatg ggtagtagtg 60actctaacgt tttttattat taagacgatc cccggagatc cttttaatga tgaaaacgga 120aacatccttt cgtcagaaac tttagcacta ttaaagaatc gttacgggtt agataagcct 180ttattcaccc agtatcttat ctatttgaaa tgtctgctaa cactagattt cggggaatct 240cttatctaca aagatcgtac tgtgatcagt attattgctg ccgctcttcc atcttccgct 300attcttggac ttgaaagctt gtgtttatcc ctcttcggag gcattactct tggaattctg 360gcagctttct ataaaaaaag ctgcggccga actattttct tttcttctgt gattcagata 420tcagtacccg cctttgttat aggagccttt ttacaatatg tttttgctat aaaatattct 480tgtctaccca tagcttgctg gggaaatttc tctcacacct tattgccctc aatagcttta 540gcaattactc ctatggcatt cattactcag ctaacctgtg cctctgtttc cgccaattta 600aaaaaagatt acgtcttatt agcttacgct aaaggacttt ctccttttaa ggtgttaata 660aaacacattt tgccctacgc tttattccct gtgatttcgt actcagcttt tcttataaca 720actttaatga ctggaacctt ctctatagaa aaccttttct gcatccccgg tcttgggaaa 780tggttcattt gcagtattaa acaaagagac taccctatca ccttaggact ttctgtgttt 840tacggggcct ttttcatgct aacttcactt tgttgcgacc ttctgcaagc gtggatagat 900ccacaaattc gttattctta tgggaaagaa cgttctaaa 939<210>554<211>3711<212>DNA<213>沙眼衣原体D血清变型<400>554ttgacctgga ttccattaca ttgccactct cagtattcca tcttggatgc aacatgctca 60atcaagaagt ttgttgccaa agcagtggaa tatcaaattc ccgcgctcgc tcttaccgat 120cacgggaatt tgtttggcgc ggtcgaattt tataagacct gtaaacaaaa cgcgattaaa 180cctatcatcg ggtgtgagct atacgtcgca ccctcttctc gtttcgataa aaaaaaagaa 240cgaaaaagcc gagttgccaa ccatctcatc cttctttgta aagatgaaga agggtatcgc 300aacctttgtt tgctctcctc tcttgcttac acagaaggtt tttactatgt gcctcgcata 360gatagagatc ttttgagcca acactccaaa ggacttatct gcttatcagc ctgtttatcc 420ggatcggttg ctcaagctgc attggaatct gaagaagatt tagaaaaaga tcttttatgg 480tatcaagatc tgtttcaaga agactttttc agtgaagtac aactccacaa atcctcagaa 540gaaaaagttg ctctatttga agaaacttgg ttaaaacaaa actactatca attcattgag 600aaacaactca aagtaaatga agctgtttta gctacttcta aacgccttgg tattccttca 660gttgctacaa atgatattca ctatttgaat ccggacgatt ggctcgctca tgaaatttta 720ctcaatgttc agtctagaga gcctattcgg acagctaaac aaaatactta cattcccaat 780cctaaacgca aaacctatcc tagtagggaa ttttatttta aatcccctca agagatcgca 840gagctatttg cagcacatcc agagactatt accaatacgt gtatcgttgc cgagcgctgc 900cacctagagc ttgattttga aaccaaacac tatcctatct acgtcccaga agctttacaa 960aaaaaaggat cctacacaga agaggagcgc tacaaagcat cctcagcctt cttagaagaa 1020ctttgcgagc aaggattaac cagcaaatac acacccgagc ttctaggaca cattgcaaag 1080aaattccctg gggaagaccc tcttacgctg gttaaagaac gtctcaaatt ggaatcctct 1140attattatct ccaaagggat gtgcgattac ttgctcattg tctgggatat tattaactgg 1200gcaaaagatc atgggattcc tgttggcccc ggtcgaggct ctggagcggg ctctgtcatg 1260cttttccttc tggggattac tgaaatagaa ccgattcgct tcgacctttt cttcgaacgt 1320ttcatcaacc cggaacggat atcgtatccc gatatcgata tcgatatctg tatgattggc 1380agagagcgcg ttattaacta tgctatagaa cgtcatggta aagataatgt agcccaaatt 1440attacatttg gcaccatgaa agccaaaatg gctattaagg atgtgggtag aactttagat 1500acccccttag ctaaagtgaa cttcatcgcg aaacatattc ccgatcttaa tgctaccatt 1560acttcggcat tagaggctga tccagaatta aggcaactgt atgtagatga cgctgaagct 1620gcagaagtta ttgatatggc taaaaaacta gagggatcta tccgcaatac tggagtgcat 1680gctgcgggag tgattatctg tggagatcct ctcactaacc atatcccgat ttgtgtccct 1740aaagactcat ccatgatttc tactcagtac tcaatgaagc cagtagaaag cgttggcatg 1800cttaaagtgg attttttggg tctaaaaacc ttaaccggca ttcacatcgc cacacaggcg 1860atctataaaa aaacaggcat tctactccgg gctgccacga ttcctctaga tgaccagaat 1920actttctctc ttcttcatca aggtaaaacc atggggatct tccaaatgga atctcgtggc 1980atgcaagacc ttgctaaaaa cttacgccca gatgcgtttg aagaaattat agcgatcgga 2040gccctctatc gccctggccc tatggatatg atcccatcat ttatcaatag gaagcatggt 2100aaagagaata ttgaatacga ccatcctctc atggaaccta ttctaaaaga aacttttgga 2160attatggttt accaagaaca agtcatgcag attgccggtt cattagcaaa atactctttg 2220ggagaagggg atgttttacg ccgcgctatg gggaaaaaag accatgaaca gatggtcaag 2280gaacgagaga aattttgttc aagagccgca gcgaatggca tcgacccttc catagcaacg 2340actatcttcg ataagatgga aaagtttgct tcctatggat ttaataagtc ccatgccgca 2400gcttacggtc ttataaccta cacaacagca tatcttaaag ccaactaccc caaagaatgg 2460cttgccgccc ttctcacttg cgattatgac gatattgaga aagttgggaa gctaattcaa 2520gaagctcaca gtatgaacat tctcgttctg cctcctgata ttaatgagtc tggacaagat 2580tttgaagcca ctcagaaagg gattcgcttt tctctaggag ctgtcaaagg cgttggaatg 2640agcattgtgg atagtattgt tgaagagaga gaaaaaaacg gcccctataa aagtctgcag 2700gatttcgttc aacgcgcaga ttttaaaaaa gtcactaaga aacagcttga aaatttggtg 2760gatgcaggaa cctttgactg cttcgaacct aataaagatc ttgcgctggc aatccttaat 2820gacctttacg acacgttctc tagagaaaaa aaagaagctg ctacaggagt cctaaccttt 2880ttttcactag atagcatggc tagagatcct gttaaaatta ctgtctctcc tgaaaatgtt 2940atccaacgct ctcctaagga gttgttgaaa agagaaaaag aattacttgg agtatatttg 3000actgcccatc ctatggatgc tgttgaacac atgctccctt tcttatctgt agtcccagct 3060cgagattttg aaggactccc tcatggaacc attattcgta cagtctttct aatcgataaa 3120gtcactacta aaatttcctc tgcagagcag aaaaaatttg cacttttaca agtcagcgat 3180gaagtcgatt catatgaact tccaatctgg gccgatatgt acgccgaata ccgtgatcta 3240ttggaagaag atcgtcttat ttatgccatt ttggctatag atcgacgtag tgattccttg 3300cgtctatctt gtcggtggat gcgagactta tctaccgtta atgattcagt aattgcggaa 3360tgcgacgaag tctatgatcg actgaaaagt cagaaagtat actcttcaac gaaaaaatca 3420accggagccc agtcctcagc aatgataaag aaagtagaga ctagagagat ctctcccgta 3480accatctctt tagatttaaa taaattacgc catagccact tatttattct caaagggctg 3540atacgcaaat attctggatc tcaagcactc tctcttgtat tcacaaaaga taatcagcgg 3600ttcgcctcta tctctccaga tgcagatttt ttcgtaacag atgatatctc ttctcttctt 3660caagaaattg aagcaaccaa tatccctgct cgcgttctag ccactacagt a 3711<210>555<211>1689<212>DNA<213>沙眼衣原体D血清变型<400>555atggtttatt ttagagctca tcaacctagg catacgccta aaacatttcc tttggaagtt 60caccattcgt tctccgataa gcatcctcaa attgctaaag ctatgcggat tacggggata 120gccctcgcag ctctatctct gctcgctgta gtcgcctgcg ttattgccgt ctctgcggga 180ggagctgcca ttcctcttgc tgtcattagt ggaattgctg taatgtctgg cctcttatcc 240gctgccacca ttatctgttc tgcaaaaaag gctttggctc aacgaaaaca aaaacaacta 300gaagagtcgc ttccgttaga taatgcgacc gagcatgtga gttacctgac ctcagacacc 360tcttatttta atcaatggga atccttaggt gctctaaata agcagttgtc tcagattgac 420ttaactattc aagctcccga aaaaaaacta ttaaaagaag ttcttggttc cagatacgat 480tccattaatc actccatcga agagatctcc gatcgcttta cgaaaatgct ctctcttctt 540cgattaagag aacattttta tcgaggagaa gagcgttatg ccccctattt aagccctcct 600ctacttaaca agaatcgttt gctgacccaa atcacatcca atatgattag gatgctacca 660aaatccggtg gtgttttttc cctcaaagcc aatacactaa gtcatgccag ccgcacacta 720tatacagtat taaaagtcgc tttatcctta ggagttctcg ctggagtcgc tgctcttatc 780atctttcttc cccctagcct gccttttatc gctgttatag gagtatcttc cttagcattg 840gggatggcat ctttccttat gattcggggc attaagtatt tgctcgaaca ttctcctctg 900aatagaaagc aactagctaa agatattcaa aaaaccattg gcccagatgt cttggcctct 960atggttcatt accagcatca attactatca catctacatg aaactctatt agatgaagcc 1020atcacagcta gatggagcga gcccttcttt attgaacacg ctaatcttaa ggcaaaaatt 1080gaagatttga caaaacaata tgatatattg aacgcagcct ttaataaatc tttacaacaa 1140gatgaggcgc tccgttctca attagagaaa cgagcttact tattcccaat tcctaataac 1200gacgaaaatg ctaaaactaa agaatcgcag cttctagact cagaaaatga ttcaaattct 1260gaatttcagg agattataaa taaaggacta gaagctgcca ataaacgacg agctgacgct 1320aagtcaaaat tctatacgga agacgaaacc tctgacaaaa tattctctat atggaaaccc 1380acaaagaact tggcattaga agatttgtgg agagtgcatg aagcttgcaa tgaagagcaa 1440caagctctcc tcttagaaga ttatatgagt tataaaacct cagaatgtca agctgcactc 1500caaaaagtga gtcaagaact gaaggcggca caaaaatcat tcgcagtcct agaaaagcat 1560gctctagaca gatcttatga atccagtgta gccacgatgg atttagctag agcgaatcaa 1620gaaacacacc ggcttctgaa catcctctct gaattacaac aactagcaca atacctgtta 1680gataatcac 1689<210>556<211>5253<212>DNA<213>沙眼衣原体D血清变型<400>556atgaaatggc tgtcagctac tgcggtgttt gctgctgttc tcccctcagt ttcagggttt 60tgcttcccag aacctaaaga attaaatttc tctcgcgtag gaacttcttc ctctaccact 120tttactgaaa cagttggaga agctggggca gaatatatcg tctctggtaa cgcatctttc 180acaaaattta ccaacattcc tactaccgat acaacaactc ccacgaactc aaactcctct 240agctctaacg gagagactgc ttccgtttct gaggatagtg actctacaac aacgactcct 300gatcctaaag gtggcggcgc cttttataac gcgcactccg gagttttatc ctttatgaca 360cgatcaggaa cagaaggttc cttaactctg tctgagataa aaataactgg tgaaggcggt 420gctatcttct ctcaaggaga gctgctattt acagatctga caggtctaac catccaaaat 480aacttatccc agctatccgg aggagcgatt tttggagaat ctacaatctc cctatcaggg 540attactaaag cgactttctc ctccaactct gcagaagttc ctgctcctgt taagaaacct 600acagaaccta aagctcaaac agcaagcgaa acgtcgggtt ctagtagttc tagcggaaat 660gattcggtgt cttcccccag ttccagtaga gctgaacccg cagcagctaa tcttcaaagt 720cactttattt gtgctacagc tactcctgct gctcaaaccg atacagaaac atcaactccc 780tctcataagc caggatctgg gggagctatc tatgctaaag gcgaccttac tatcgcagac 840tctcaagagg tactattctc aataaataaa gctactaaag atggaggagc gatctttgct 900gagaaagatg tttctttcga gaatattaca tcattaaaag tacaaactaa cggtgctgaa 960gaaaagggag gagctatcta tgctaaaggt gacctctcaa ttcaatcttc taaacagagt 1020ctttttaatt ctaactacag taaacaaggt ggtggggctc tatatgttga aggagatata 1080aacttccaag atcttgaaga aattcgcatt aagtacaata aagctggaac gttcgaaaca 1140aaaaaaatca ctttaccaaa agctcaagca tctgcaggaa atgcagatgc ttgggcctct 1200tcctctcctc aatctggttc tggagcaact acagtctcca actcaggaga ctctagctct 1260ggctcagact cggatacctc agaaacagtt ccagccacag ctaaaggcgg tgggctttat 1320actgataaga atctttcgat tactaacatc acaggaatta tcgaaattgc aaataacaaa 1380gcgacagatg ttggaggtgg tgcttacgta aaaggaaccc ttacttgtga aaactctcac 1440cgtctacaat ttttgaaaaa ctcttccgat aaacaaggtg gaggaatcta cggagaagac 1500aacatcaccc tatctaattt gacagggaag actctattcc aagagaatac tgccaaagaa 1560gagggcggtg gactcttcat aaaaggtaca gataaagctc ttacaatgac aggactggat 1620agtttctgtt taattaataa cacatcagaa aaacatggtg gtggagcctt tgttaccaaa 1680gaaatctctc agacttacac ctctgatgtg gaaacaattc caggaatcac gcctgtacat 1740ggtgaaacag tcattactgg caataaatct acaggaggta atggtggagg cgtgtgtaca 1800aaacgtcttg ccttatctaa ccttcaaagc atttctatat ccgggaattc tgcagctgaa 1860aatggtggtg gagcccacac atgcccagat agcttcccaa cggcggatac tgcagaacag 1920cccgcagcag cttctgccgc gacgtctact cccgagtctg ccccagtggt ctcaactgct 1980ctaagcacac cttcatcttc taccgtctct tcattaacct tactagcagc ctcttcacaa 2040gcctctcctg caacctctaa taaggaaact caagatccta atgctgatac agacttattg 2100atcgattatg tagttgatac gactatcagc aaaaacactg ctaagaaagg cggtggaatc 2160tatgctaaaa aagccaagat gtcccgcata gaccaactga atatctctga gaactccgct 2220acagagatag gtggaggtat ctgctgtaaa gaatctttag aactagatgc cctagtctcc 2280ttatctgtaa cagagaacct tgttgggaaa gaaggtggag gcttacatgc taaaactgta 2340aatatttcta atctgaaatc aggcttctct ttctcgaaca acaaagcaaa ctcctcatcc 2400acaggagtcg caacaacagc ttcagcacct gctgcagctg ctgcttccct acaagcagcc 2460gcagcagccg taccatcatc tccagcaaca ccaacttatt caggtgtagt aggaggagct 2520atctatggag aaaaggttac attctctcaa tgtagcggga cttgtcagtt ctctgggaac 2580caagctatcg ataacaatcc ctcccaatca tcgttgaacg tacaaggagg agccatctat 2640gccaaaacct ctttgtctat tggatcttcc gatgctggaa cctcctatat tttctcgggg 2700aacagtgtct ccactgggaa atctcaaca acagggcaaa tagcgggagg agcgatctac 2760tcccctactg ttacattgaa ttgtcctgcg acattctcta acaatacagc ctctatggct 2820acaccaaaga cttcttctga agatggatcc tcaggaaatt ctattaaaga taccattgga 2880ggagccattg cagggacagc cattacccta tctggagtct ctcgattttc agggaatacg 2940gctgatttag gagctgcaat aggaactcta gctaatgcaa atacacccag tgcaactagc 3000ggatctcaaa atagcattac agaaaaaatt actttagaaa acggttcttt tatttttgaa 3060agaaaccaag ctaataaacg tggagcgatt tactctccta gcgtttccat taaagggaat 3120aatattacct tcaatcaaaa tacatccact catgatggaa gtgctatcta ctttacaaaa 3180gatgctacga ttgagtcttt aggatctgtt ctttttacag gaaataacgt tacagctaca 3240caagctagtt ctgcaacatc tggacaaaat acaaatactg ccaactatgg ggcagccatc 3300tttggagatc caggaaccac tcaatcgtct caaacagatg ccattttaac ccttcttgct 3360tcttctggaa acattacttt tagcaacaac agtttacaga ataaccaagg tgatactccc 3420gctagcaagt tttgtagtat tgcaggatac gtcaaactct ctctacaagc cgctaaaggg 3480aagactatta gctttttcga ttgtgtgcac acctctacca aaaaaatagg ttcaacacaa 3540aacgtttatg aaactttaga tattaataaa gaagagaaca gtaatccata tacaggaact 3600attgtgttct cttctgaatt acatgaaaac aaatcttaca tcccacagaa tgcaatcctt 3660cacaacggaa ctttagttct taaagagaaa acagaactcc acgtagtctc ttttgagcag 3720aaagaagggt ctaaattaat tatgaaaccc ggagctgtgt tatctaacca aaacatagct 3780aacggagctc tagttatcaa tgggttaacg attgatcttt ccagtatggg gactcctcaa 3840gcaggggaaa tcttctctcc tccagaatta cgtatcgttg ccacgacctc tagtgcatcc 3900ggaggaagcg gggtcagcag tagtatacca acaaatccta aaaggatttc tgcagcagcg 3960ccttcaggtt ctgccgcaac tactccaact atgagcgaga acaaagtttt cctaacagga 4020gaccttactt taatagatcc taatggaaac ttttaccaaa accctatgtt aggaagcgat 4080ctagatgtac cactaattaa gcttccgact aacacaagtg acgtccaagt ctatgattta 4140actttatctg gggatctttt ccctcagaaa gggtacatgg gaacctggac attagattct 4200aatccacaaa cagggaaact tcaagccaga tggacattcg atacctatcg tcgctgggta 4260tacataccta gggataatca tttttatgcg aactctatct taggctccca aaactcaatg 4320attgttgtga agcaagggct tatcaacaac atgttgaata atgcccgctt cgatgatatc 4380gcttacaata acttctgggt ttcaggagta ggaactttct tagctcaaca aggaactcct 4440ctttccgaag aattcagtta ctacagccgc ggaacttcag ttgccatcga tgccaaacct 4500agacaagatt ttatcctagg agctgcattt agtaagatgg tggggaaaac caaagccatc 4560aaaaaaatgc ataattactt ccataagggc tctgagtact cttaccaagc ttctgtctat 4620ggaggtaaat tcctgtattt cttgctcaat aagcaacatg gttgggcact tcctttccta 4680atacaaggag tcgtgtccta tggacatatt aaacatgata caacaacact ttacccttct 4740atccatgaaa gaaataaagg agattgggaa gatttaggat ggttagcgga tcttcgtatc 4800tctatggatc ttaaagaacc ttctaaagat tcttctaaac ggatcactgt ctatggggaa 4860cttgagtatt ccagcattcg ccagaaacag ttcacagaaa tcgattacga tccaagacac 4920ttcgatgatt gtgcttacag aaatctgtcg cttcctgtgg gatgcgctgt cgaaggagct 4980atcatgaact gtaatattct tatgtataat aagcttgcat tagcctacat gccttctatc 5040tacagaaata atcctgtctg taaatatcgg gtattgtctt cgaatgaagc tggtcaagtt 5100atctgcggag tgccaactag aacctctgct agagcagaat acagtactca actatatctt 5160ggtcccttct ggactctcta cggaaactat actatcgatg taggcatgta tacgctatcg 5220caaatgacta gctgcggtgc tcgcatgatc ttc 5253<210>557<211>792<212>DNA<213>沙眼衣原体D血清变型<400>557atgggaaatt ctggttttta tttgtataac actgaaaact gcgtctttgc tgataatatc 60aaagttgggc aaatgacaga gccgctcaag gaccagcaaa taatccttgg gacaaaatca 120acacctgtcg cagccaaaat gacagcttct gatggaatat ctttaacagt ctccaataat 180tcatcaacca atgcttctat tacaattggt ttggatgcgg aaaaagctta ccagcttatt 240ctagaaaagt tgggaaatca aattcttgat ggaattgctg atactattgt tgatagtaca 300gtccaagata ttttagacaa aatcacaaca gacccttctc taggtttgtt gaaagctttt 360aacaactttc caatcactaa taaaattcaa tgcaacgggt tattcactcc cagtaacatt 420gaaactttat taggaggaac tgaaatagga aaattcacag tcacacccaa aagctctggg 480agcatgttct tagtctcagc agatattatt gcatcaagaa tggaaggcgg cgttgttcta 540gctttggtac gagaaggtga ttctaagccc tgcgcgatta gttatggata ctcatcaggc 600gttcctaatt tatgtagtct aagaaccagc attactaata caggattgac accaacaacg 660tattcattac gtgtaggcgg tttagaaagc ggtgtggtat gggttaatgc cctttctaat 720ggcaatgata ttttaggaat aacaaatact tctaatgtat cttttttgga agtaatacct 780caaacaaacg ct 792<210>558<211>306<212>DNA<213>沙眼衣原体D血清变型<400>558atgcaaaata aaagaaaagt gagggacgat tttattaaaa ttgttaaaga tgtgaaaaaa 60gatttccccg aattagacct aaaaatacga gtaaacaagg aaaaagtaac tttcttaaat 120tctcccttag aactctacca taaaagtgtc tcactaattc taggactgct tcaacaaata 180gaaaactctt taggattatt cccagactct cctgttcttg aaaaattaga ggataacagt 240ttaaagctaa aaaaggcttt gattatgctt atcttgtcta gaaaagacat gttttccaag 300gctgaa 306<210>559<211>729<212>DNA<213>沙眼衣原体D血清变型<400>559gtgggatgca acttggccca atttttaggg aaaaaagtgt tacttgctga cctagacccg 60caatccaatt tatcttctgg attgggggct agtgtcagaa ataaccaaaa aggcttgcac 120gacatagtat acaaatcaaa cgatttaaaa tcaatcattt gcgaaacaaa aaaagatagt 180gtggacctaa ttcctgcatc atttttatcc gaacagttta gagaattgga tattcataga 240ggacctagta acaacttaaa gttatttctg aatgagtact gcgctccttt ttatgacatc 300tgcataatag acactccacc tagcctagga gggttaacga aagaagcttt tgttgcagga 360gacaaattaa ttgcttgttt aactccagaa cctttttcta ttctagggtt acaaaagata 420cgtgaattct taagttcggt cggaaaacct gaagaagaac acattcttgg aatagctttg 480tctttttggg atgatcgtaa ctcgactaac caaatgtata tagacattat cgagtctatt 540tacaaaaaca agcttttttc aacaaaaatt cgtcgagata tttctctcag ccgttctctt 600cttaaagaag attctgtagc taatgtctat ccaaattcta gggccgcaga agatattctg 660aagttaacgc atgaaatagc aaatattttg catatcgaat atgaacgaga ttactctcag 720aggacaacg 729<210>560<211>289<212>PRT<213>沙眼衣原体D血清变型<400>560Met Thr His Gln His Lys Lys Ile Ser Glu Glu Thr Ile Ala Cys Asp1 5 10 15Met Leu Glu Arg Tyr Thr Gly Ser Thr Val Gln Glu Phe Gln Pro Tyr

20 25 30Leu Leu Leu Thr Asn Phe Ala Tyr Tyr Val Asp Val Phe Ala Glu Ile

35 40 45Tyr Gln Val Pro Val Ser Arg Gly Ser Met Phe Ser Ala Ala His Ala

50 55 60Pro Gln Ile His Thr Ser Ile Ile Asp Phe Lys Leu Gly Ser Pro Gly65 70 75 80Ala Ala Leu Thr Val Asp Leu Cys Ser Phe Leu Pro Asn Ala Thr Ala

85 90 95Ala Ile Met Leu Gly Met Cys Gly Gly Leu Arg Ser His Tyr Gln Ile

100 105 110Gly Asp Tyr Phe Val Pro Val Ala Ser Ile Arg Lys Asp Gly Thr Ser

115 120 125Asp Ala Tyr Phe Pro Pro Glu Val Pro Ala Leu Ala Asn Phe Val Val

130 135 140Gln Lys Met Ile Thr Asn Ile Leu Glu Ala Lys Asn Leu Pro Tyr His145 150 155 160Ile Gly Ile Thr His Thr Thr Asn Ile Arg Phe Trp Glu Phe Asn Lys

165 170 175Glu Phe Arg Arg Lys Leu Tyr Glu Asn Lys Ala Gln Thr Val Glu Met

180 185 190Glu Cys Ala Thr Leu Phe Ala Ala Gly Tyr Arg Arg Asn Leu Pro Leu

195 200 205Gly Ala Leu Leu Leu Ile Ser Asp Leu Pro Leu Arg Lys Asp Gly Ile

210 215 220Lys Thr Lys Glu Ser Ser Ser Ala Val Leu Asn Ser His Thr Lys Glu225 230 235 240His Ile Leu Thr Gly Val Glu Val Phe Ala Ser Leu Gln Glu Lys Ser

245 250 255Gly Pro Gly Ile Lys Lys Thr Lys Gly Leu Pro His Met Glu Phe Gly

260 265 270Gln Ala Asp Asp Ser Leu Ser Glu Gln Thr Glu Val Ser Gly Gly Asp

275 280 285Phe<210>561<211>394<212>PRT<213>沙眼衣原体D血清变型<400>561Met Ser Lys Glu Thr Phe Gln Arg Asn Lys Pro His Ile Asn Ile Gly1 5 10 15Thr Ile Gly His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile

20 25 30Thr Arg Ala Leu Ser Gly Asp Gly Leu Ala Asp Phe Arg Asp Tyr Ser

35 40 45Ser Ile Asp Asn Thr Pro Glu Glu Lys Ala Arg Gly Ile Thr Ile Asn

50 55 60Ala Ser His Val Glu Tyr Glu Thr Ala Asn Arg His Tyr Ala His Val65 70 75 80Asp Cys Pro Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Ala

85 90 95Ala Gln Met Asp Gly Ala Ile Leu Val Val Ser Ala Thr Asp Gly Ala

100 105 110Met Pro Gln Thr Lys Glu His Ile Leu Leu Ala Arg Gln Val Gly Val

115 120 125Pro Tyr Ile Val Val Phe Leu Asn Lys Ile Asp Met Ile Ser Glu Glu

130 135 140Asp Ala Glu Leu Val Asp Leu Val Glu Met Glu Leu Val Glu Leu Leu145 150 155 160Glu Glu Lys Gly Tyr Lys Gly Cys Pro Ile Ile Arg Gly Ser Ala Leu

165 170 175Lys Ala Leu Glu Gly Asp Ala Ala Tyr Ile Glu Lys Val Arg Glu Leu

180 185 190Met Gln Ala Val Asp Asp Asn Ile Pro Thr Pro Glu Arg Glu Ile Asp

195 200 205Lys Pro Phe Leu Met Pro Ile Glu Asp Val Phe Ser Ile Ser Gly Arg

210 215 220Gly Thr Val Val Thr Gly Arg Ile Glu Arg Gly Ile Val Lys Val Ser225 230 235 240Asp Lys Val Gln Leu Val Gly Leu Arg Asp Thr Lys Glu Thr Ile Val

245 250 255Thr Gly Val Glu Met Phe Arg Lys Glu Leu Pro Glu Gly Arg Ala Gly

260 265 270Glu Asn Val Gly Leu Leu Leu Arg Gly Ile Gly Lys Asn Asp Val Glu

275 280 285Arg Gly Met Val Val Cys Leu Pro Asn Ser Val Lys Pro His Thr Gln

290 295 300Phe Lys Cys Ala Val Tyr Val Leu Gln Lys Glu Glu Gly Gly Arg His305 310 315 320Lys Pro Phe Phe Thr Gly Tyr Arg Pro Gln Phe Phe Phe Arg Thr Thr

325 330 335Asp Val Thr Gly Val Val Thr Leu Pro Glu Gly Ile Glu Met Val Met

340 345 350Pro Gly Asp Asn Val Glu Phe Glu Val Gln Leu Ile Ser Pro Val Ala

355 360 365Leu Glu Glu Gly Met Arg Phe Ala Ile Arg Glu Gly Gly Arg Thr Ile

370 375 380Gly Ala Gly Thr Ile Ser Lys Ile Ile Ala385 390<210>562<211>550<212>PRT<213>沙眼衣原体D血清变型<400>562Met Glu Ser Ser Arg Ile Leu Ile Thr Ser Ala Leu Pro Tyr Ala Asn1 5 10 15Gly Pro Leu His Phe Gly His Ile Thr Gly Ala Tyr Leu Pro Ala Asp

20 25 30Val Tyr Ala Arg Phe Gln Arg Leu Gln Gly Lys Glu Val Leu Tyr Ile

35 40 45Cys Gly Ser Asp Glu Tyr Gly Ile Ala Ile Thr Leu Asn Ala Glu Leu

50 55 60Ala Gly Met Gly Tyr Gln Glu Tyr Val Asp Met Tyr His Lys Leu His65 70 75 80Lys Asp Thr Phe Lys Lys Leu Gly Ile Ser Val Asp Phe Phe Ser Arg

85 90 95Thr Thr Asn Thr Tyr His Pro Ala Ile Val Gln Asp Phe Tyr Arg Asn

100 105 110Leu Gln Glu Arg Gly Leu Val Glu Asn Gln Val Thr Glu Gln Leu Tyr

115 120 125Ser Glu Glu Glu Gly Lys Phe Leu Ala Asp Arg Tyr Val Val Gly Thr

130 135 140Cys Pro Lys Cys Gly Phe Asp Arg Ala Arg Gly Asp Glu Cys Gln Gln145 150 155 160Cys Gly Ala Asp Tyr Glu Ala Arg Asp Leu Lys Glu Pro Arg Ser Lys

165 170 175Leu Thr Gly Ala Ala Leu Ser Leu Arg Asp Thr Glu His Ala Tyr Leu

180 185 190His Leu Glu Arg Met Lys Glu Asp Leu Leu Ala Phe Val Gln Gly Ile

195 200 205Tyr Leu Arg Pro His Met Arg Asn Phe Val Thr Asp Tyr Ile Glu His

210 215 220Leu Arg Pro Arg Ala Val Thr Arg Asp Leu Ser Trp Gly Ile Pro Val225 230 235 240Pro Asp Leu Glu Asn Lys Val Phe Tyr Val Trp Phe Asp Ala Pro Ile

245 250 255Gly Tyr Ile Ser Gly Thr Met Asp Trp Ala Ala Ser Ile Gly Asp Pro

260 265 270Glu Ala Trp Lys Lys Phe Trp Leu Asp Asp Thr Val Thr Tyr Ala Gln

275 280 285Phe Ile Gly Lys Asp Asn Thr Ser Phe His Ala Ala Ile Phe Pro Ala

290 295 300Met Glu Ile Gly Gln Ser Leu Pro Tyr Lys Lys Val Asp Ala Leu Val305 310 315 320Thr Ser Glu Phe Leu Leu Leu Glu Gly Phe Gln Phe Ser Lys Ser Asp

325 330 335Gly Asn Phe Ile Asp Met Asp Ala Phe Leu Glu Thr Tyr Ser Leu Asp

340 345 350Lys Leu Arg Tyr Val Leu Ala Ala Ile Ala Pro Glu Thr Ser Asp Ser

355 360 365Glu Phe Ser Phe Gln Glu Phe Lys Thr Arg Cys Asn Ser Glu Leu Val

370 375 380Gly Lys Tyr Gly Asn Phe Val Asn Arg Val Leu Ala Phe Ala Val Lys385 390 395 400Asn Gly Cys Thr Glu Leu Ser Ser Pro Gln Leu Glu Gln Lys Asp Leu

405 410 415Asp Phe Ile Ser Lys Ser Gln Lys Leu Ala Lys Asp Ala Ala Glu His

420 425 430Tyr Ala Gln Tyr Ser Leu Arg Lys Ala Cys Ser Thr Ile Met Glu Leu

435 440 445Ala Ala Leu Gly Asn Gly Tyr Phe Asn Asp Glu Ala Pro Trp Lys Leu

450 455 460Ala Lys Glu Gly Asn Trp Asn Arg Val Arg Ala Ile Leu Phe Cys Ala465 470 475 480Cys Tyr Cys Gln Lys Leu Leu Ala Leu Ile Ser Tyr Pro Ile Met Pro

485 490 495Glu Thr Ala Leu Lys Ile Leu Glu Met Ile Ala Pro His Ser Leu Asp

500 505 510Leu Gly Ser Gln Asp Pro Asp Arg Leu Gln Ser Leu Trp Thr Asp Ser

515 520 525Phe Phe Asp Tyr Ser Glu Glu Lys Phe Ser Leu Lys Glu Pro Glu Leu

530 535 540Leu Phe Thr Met Val Glu545 550<210>563<211>100<212>PRT<213>沙眼衣原体D血清变型<400>563Met Ala Arg Lys Asp Arg Leu Thr Asn Glu Arg Leu Asn Lys Leu Phe1 5 10 15Asp Ser Pro Phe Ser Leu Val Asn Tyr Val Ile Lys Gln Ala Lys Asn

20 25 30Lys Ile Ala Arg Gly Asp Val Arg Ser Ser Asn Val Ala Ile Glu Ala

35 40 45Leu Asn Phe Leu Asp Leu Tyr Gly Ile Gln Ser Glu Tyr Ala Glu Arg

50 55 60Asp Asp Arg Glu Arg His Leu Ser Ala Thr Gly Glu Arg Arg Arg Glu65 70 75 80Gln Gly Phe Gly Thr Ser Arg Arg Lys Asp Pro Ser Leu Tyr Asn Trp

85 90 95Ser Asp Val Lys

100<210>564<211>205<212>PRT<213>沙眼衣原体D血清变型<400>564Met Ser Val Lys Val Ile Ser Pro Phe Ser Gln Asp Gly Val Gln Cys1 5 10 15Phe Pro Lys Leu Phe Ile Ile Ser Ala Pro Ala Gly Ala Gly Lys Thr

20 25 30Thr Leu Thr His Met Leu Gln Arg Glu Phe Pro Asp Ala Phe Glu Lys

35 40 45Thr Val Ser Ser Thr Thr Arg Ser Ala Arg Pro Gly Glu Val His Gly

50 55 60Val Asp Tyr Leu Phe Val Ser Glu Asp Asp Phe Lys Gln Ser Leu Asp65 70 75 80Arg Glu Asp Phe Leu Glu Trp Val Phe Leu Phe Gly Thr Tyr Tyr Gly

85 90 95Thr Ser Lys Ala Glu Ile Ser Arg Val Leu Gln Lys Gly Lys His Cys

100 105 110Ile Ala Val Ile Asp Val Gln Gly Ala Leu Ala Leu Lys Lys Gln Met

115 120 125Pro Ala Val Thr Ile Phe Ile Gln Ala Pro Ser Gln Glu Glu Leu Glu

130 135 140Arg Arg Leu Asn Ala Arg Asp Ser Glu Lys Asp Phe Gln Lys Lys Glu145 150 155 160Arg Leu Glu His Ser Ala Val Glu Ile Ala Ala Ala Ser Glu Phe Asg

165 170 175Tyr Val Val Val Asn Asp Asp Leu Ile Thr Ala Tyr Gln Val Leu Arg

180 185 190Ser Ile Phe Ile Ala Glu Glu His Arg Met Ser His Gly

195 200 205<210>565<211>602<212>PRT<213>沙眼衣原体D血清变型<400>565Met Lys Pro Tyr Lys Ile Glu Asn Ile Arg Asn Phe Ser Ile Ile Ala1 5 10 15His Ile Asp His Gly Lys Ser Thr Ile Ala Asp Arg Leu Leu Glu Ser

20 25 30Thr Ser Thr Ile Glu Gln Arg Glu Met Arg Glu Gln Leu Leu Asp Ser

35 40 45Met Asp Leu Glu Arg Glu Arg Gly Ile Thr Ile Lys Ala His Pro Val

50 55 60Thr Met Thr Tyr Glu Tyr Glu Gly Glu Thr Tyr Glu Leu Asn Leu Ile65 70 75 80Asp Thr Pro Gly His Val Asp Phe Ser Tyr Glu Val Ser Arg Ser Leu

85 90 95Ala Ala Cys Glu Gly Ala Leu Leu Ile Val Asp Ala Ala Gln Gly Val

100 105 110Gln Ala Gln Ser Leu Ala Asn Val Tyr Leu Ala Leu Glu Arg Asp Leu

115 120 125Glu Ile Ile Pro Val Leu Asn Lys Ile Asp Leu Pro Ala Ala Gln Pro

130 135 140Glu Ala Ile Lys Lys Gln Ile Glu Glu Phe Ile Gly Leu Asp Thr Ser145 150 155 160Asn Thr Ile Ala Cys Ser Ala Lys Thr Gly Gln Gly Ile Pro Glu Ile

165 170 l75Leu Glu Ser Ile Ile Arg Leu Val Pro Pro Pro Lys Pro Pro Gln Glu

180 185 190Thr Glu Leu Lys Ala Leu Ile Phe Asp Ser His Tyr Asp Pro Tyr Val

195 200 205Gly Ile Met Val Tyr Val Arg Val Ile Ser Gly Glu Ile Lys Lys Gly

210 215 220Asp Arg Ile Thr Phe Met Ala Thr Lys Gly Ser Ser Phe Glu Val Leu225 230 235 240Gly Ile Gly Ala Phe Leu Pro Glu Ala Thr Leu Met Glu Gly Ser Leu

245 250 255Arg Ala Gly Gln Val Gly Tyr Phe Ile Ala Asn Leu Lys Lys Val Lys

260 265 270Asp Val Lys Ile Gly Asp Thr Val Thr Thr Val Lys His Pro Ala Lys

275 280 285Glu Pro Leu Glu Gly Phe Lys Glu Ile Lys Pro Val Val Phe Ala Gly

290 295 300Ile Tyr Pro Ile Asp Ser Ser Asp Phe Asp Thr Leu Lys Asp Ala Leu305 310 315 320Gly Arg Leu Gln Leu Asn Asp Ser Ala Leu Thr Ile Glu Gln Glu Asn

325 330 335Ser His Ser Leu Gly Phe Gly Phe Arg Cys Gly Phe Leu Gly Leu Leu

340 345 350His Leu Glu Ile Ile Phe Glu Arg Ile Ser Arg Glu Phe Asp Leu Asp

355 360 365Ile Ile Ala Thr Ala Pro Ser Val Ile Tyr Lys Val Val Leu Lys Asn

370 375 380Gly Lys Thr Leu Phe Ile Asp Asn Pro Thr Ala Tyr Pro Asp Pro Ala385 390 395 400Leu Ile Glu His Met Glu Glu Pro Trp Val His Val Asn Ile Ile Thr

405 410 415Pro Gln Glu Tyr Leu Ser Asn Ile Met Ser Leu Cys Met Asp Lys Arg

420 425 430Gly Ile Cys Leu Lys Thr Asp Met Leu Asp Gln His Arg Leu Val Leu

435 440 445Ser Tyr Glu Leu Pro Leu Asn Glu Ile Val Ser Asp Phe Asn Asp Lys

450 455 460Leu Lys Ser Val Thr Lys Gly Tyr Gly Ser Phe Asp Tyr Arg Leu Gly465 470 475 480Asp Tyr Lys Lys Gly Ala Ile Ile Lys Leu Glu Ile Leu Ile Asn Asp

485 490 495Glu Ala Val Asp Ala Phe Ser Cys Leu Val His Arg Asp Lys Ala Glu

500 505 510Ser Lys Gly Arg Ser Ile Cys Glu Lys Leu Val Asp Val Ile Pro Pro

515 520 525Gln Leu Phe Lys Ile Pro Ile Gln Ala Ala Ile Asn Lys Lys Ile Ile

530 535 540Ala Arg Glu Thr Ile Arg Ala Leu Ala Lys Asn Val Thr Ala Lys Cys545 550 555 560Tyr Gly Gly Asp Ile Thr Arg Lys Arg Lys Leu Trp Asp Lys Gln Lys

565 570 575Lys Gly Lys Lys Arg Met Lys Glu Phe Gly Lys Val Ser Ile Pro Asn

580 585 590Thr Ala Phe Val Glu Val Leu Lys Met Glu

595 600<210>566<211>324<212>PRT<213>沙眼衣原体D血清变型<400>566Met Glu Leu Leu Pro His Glu Lys Gln Val Val Glu Tyr Glu Lys Thr1 5 10 15Ile Ala Glu Phe Lys Glu Lys Asn Lys Glu Asn Ser Leu Leu Ser Ser

20 25 30Ser Glu Ile Gln Lys Leu Asp Lys Arg Leu Asp Arg Leu Lys Glu Lys

35 40 45Ile Tyr Ser Asp Leu Thr Pro Trp Glu Arg Val Gln Ile Cys Arg His

85 90 95Val Gly Gly Phe Ala Lys Ile Gln Gly Gln Arg Phe Met Leu Ile Gly

100 105 110Gln Glu Lys Gly Cys Asp Thr Lys Ser Arg Met His Arg Asn Phe Gly

115 120 125Met Leu Cys Pro Glu Gly Phe Arg Lys Ala Leu Arg Leu Ala Lys Met

130 135 140Ala Glu Lys Phe Gly Leu Pro Ile Ile Phe Leu Val Asp Thr Pro Gly145 150 155 160Ala Phe Pro Gly Leu Thr Ala Glu Glu Arg Gly Gln Gly Trp Ala Ile

165 170 175Ala Thr Asn Leu Phe Glu Leu Ala Arg Leu Ala Thr Pro Ile Ile Val

180 185 190Ile Val Ile Gly Glu Gly Cys Ser Gly Gly Ala Leu Gly Met Ala Ile

195 200 205Gly Asp Val Val Ala Met Leu Glu His Ser Tyr Tyr Ser Val Ile Ser

210 215 220Pro Glu Gly Cys Ala Ser Ile Leu Trp Lys Asp Pro Lys Lys Asn Ser225 230 235 240Asp Ala Ala Ala Met Leu Lys Met His Gly Glu Asp Leu Lys Gly Phe

245 250 255Ala Ile Val Asp Ala Val Ile Lys Glu Pro Ile Gly Gly Ala His His

260 265 270Asn Pro Ala Ala Thr Tyr Arg Ser Val Gln Glu Tyr Val Leu Gln Glu

275 280 285Trp Leu Lys Leu Lys Asp Leu Pro Val Glu Glu Leu Leu Glu Lys Arg

290 295 300Tyr Gln Lys Phe Arg Thr Ile Gly Leu Tyr Glu Thr Ser Ser Glu Ser305 310 315 320Asp Ser Glu Ala<210>567<211>646<212>PRT<213>沙眼衣原体D血清变型<400>567Met Lys Leu Leu Leu Lys Ala Ile Leu Arg His Lys Lys His Leu Val1 5 10 15Leu Phe Gly Phe Ser Leu Leu Ser Ile Leu Gly Leu Thr Ile Thr Ser

20 25 30Gln Ala Glu Ile Phe Ser Leu Gly Leu Ile Ala Lys Thr Gly Pro Asp

35 40 45Thr Phe Leu Leu Phe Gly Lys Gln Glu Gly Ala Ser Leu Val Lys Arg

50 55 60Lys Glu Leu Ser Lys Asp Gln Leu Leu Glu Gln Trp Asp Asn Ile Val65 70 75 80Gly Glu Gly Asp Thr Leu Ser Leu Pro Gln Ala Asn Ala Tyr Ile Ala

85 90 95Lys His Ser Gly Gly Ser Gln Ser Ile Thr Lys Arg Leu Ser Ala Tyr

100 105 110Leu Ser Gly Cys Phe Asp Phe Ser Arg Leu Gln Cys Leu Ala Leu Phe

115 120 125Leu Val Val Val Ala Ile Leu Lys Ser Thr Thr Leu Phe Phe Gln Arg

130 135 140Phe Leu Ala Gln Leu Ile Ala Ile Arg Val Ser Cys Ser Leu Arg Lys145 150 155 160Asp Tyr Phe Leu Ala Leu Gln Thr Leu Pro Met Thr Phe Phe His Ala

165 170 175His Asp Met Gly Asn Leu Ser Ser Arg Val Ile Ala Asp Ser Ser Met

180 185 190Ile Ala Leu Ala Ile Asn Ala Leu Met Val Asn Tyr Ile Gln Ala Pro

195 200 205Ile Thr Met Thr Leu Ala Leu Val Val Cys Leu Ser Ile Ser Trp Lys

210 215 220Phe Cys Ala Cys Val Cys Leu Ala Phe Pro Ile Phe Ile Leu Pro Ile225 230 235 240Val Ile Ile Ala Lys Lys Val Lys Ala Leu Ala Lys Arg Ile Gln Lys

245 250 255Ser Gln Asp His Ser Ala Ala Ala Leu Leu Asp Phe Leu Leu Gly Ile

260 265 270Leu Thr Val Lys Val Phe Arg Thr Glu Gln Phe Ser Phe Ser Lys Tyr

275 280 285Cys Gln Lys Asn Asp Glu Ile Ala Arg Leu Glu Glu Arg Ser Ala Ala

290 295 300Tyr Ser Leu Ile Pro Arg Pro Leu Leu His Thr Ile Ala Ser Leu Phe305 3l0 315 320Phe Ala Leu Val Ile Met Ile Gly Leu Tyr His Phe His Ile Pro Pro

325 330 335Glu Glu Leu Val Val Phe Cys Gly Leu Leu Tyr Leu Ile Tyr Asp Pro

340 345 350Ile Lys Lys Phe Ala Asp Glu Asn Ala Asn Ile Met Trp Gly Cys Ala

355 360 365Ala Ala Glu Arg Phe Tyr Glu Val Leu Asp Leu Ala Lys Gln Gln Ser

370 375 380Asn Val Ser Glu Lys Leu Asn Glu Phe Gln Gly Leu Gln His Ser Ile385 390 395 400Gln Phe Cys Asn Val Ser Phe Gly Tyr Val Glu Asp Ser Pro Val Leu

405 410 415Ser Asp Phe Asn Leu Val Leu Lys Lys Gly Glu Ala Ile Gly Ile Val

420 425 430Gly Pro Thr Gly Ser Gly Lys Ser Thr Ile Ala Lys Leu Leu Pro Arg

435 440 445Leu Tyr Glu Val Ser His Gly Glu Leu Leu Ile Asp Ser Leu Pro Ile

450 455 460Arg Ser Tyr cys Lys Asn Ser Leu Arg Lys His Ile Gly Cys Val Leu465 470 475 480Gln His Pro Phe Leu Phe Tyr Asp Thr Val Trp Asn Asn Leu Thr Cys

485 490 495Gly Arg Thr Phe Ser Glu Glu Glu Val Phe His Ala Leu Lys Gln Ala

500 505 510His Ala Tyr Glu Phe Val Ser Lys Met Pro Gln Gly Val His Ser Leu

515 520 525Leu Glu Glu Ser Ser Lys Asn Leu Ser Gly Gly Gln Gln Gln Arg Leu

530 535 540Thr Ile Ala Arg Ala Leu Leu His Asn Thr Ser Ile Leu Leu Leu Asp545 550 555 560Glu Ala Thr Ser Ala Leu Asp Ala Ile Ser Glu Asn Tyr Val Lys Glu

565 570 575Ile Val Gly Gln Leu Lys Gly Arg Cys Thr Gln Ile Ile Ile Ala His

580 585 590Lys Leu Ser Thr Leu Glu Tyr Val Asp Arg Ile Val Tyr Leu Glu Gln

595 600 605Gly Lys Lys Ile Ala Glu Gly Thr Lys Glu Glu Leu Leu Asp Ser Cys

610 615 620Pro Ala Phe Gln Arg Met Trp Val Leu Ser Gly Ala Lys Asp Trp Glu625 630 635 640Leu Asn Ala Val Val Lys

645<210>568<211>414<212>PRT<213>沙眼衣原体D血清变型<400>568Met Phe Ser Ser Ala Ile Val Ile Leu Thr Ala Ile Phe Val Leu Cys1 5 10 15Ser Gly Phe Val Ser Leu Ser His Ile Ala Leu Phe Ser Leu Pro Ser

20 25 30Ser Leu Ile Ala His Tyr Ser His Ser Lys Asn Arg Gln Leu Arg Gln

35 40 45Ile Ala Asn Leu Met Ala Tyr Pro Asn His Leu Leu Met Thr Leu Val

50 55 60Phe Phe Asp Ile Gly Ile Asn Ile Gly Val Gln Asn Cys Ile Ala Thr65 70 75 80Leu Val Gly Asp Ser Ala Ser Leu Leu Leu Thr Val Gly Val Pro Leu

85 90 95Ala Leu Thr Leu Val Leu Gly Glu Ile Val Pro Lys Val Ile Ala Ile

100 105 110Pro Tyr Asn Ala Arg Ile Ala Lys Ile Val Thr Pro Ile Ile Phe Ala

115 120 125Ser Thr Lys Ser Phe Arg Pro Ile Phe Asp Trp Ala Ile Ser Gly Ile

130 135 140Asn Phe Ile Val Gln Lys Met Leu Ala Arg Gln Glu Ser Asp Phe Ile145 150 155 160Gln Pro Gln Glu Leu Lys Glu Val Leu Arg Ser Cys Lys Asp Phe Gly

165 170 175Val Val Asn His Glu Glu Ser Arg Leu Leu Phe Gly Tyr Leu Ser Met

180 185 190Glu Glu Gly Ser Ile Lys Glu Arg Met Thr Pro Lys Gln Glu Ile Ile

195 200 205Phe Tyr Asp Val Leu Thr Pro Ile Glu Asn Leu Tyr Lys Leu Phe Ser

210 215 220Gly Pro Lys Gln Ser Tyr Ser Lys Val Leu Val Cys Lys Gly Gly Leu225 230 235 240Gln Asn Leu Leu Gly Val Cys Ser Ala Lys Leu Leu Leu Leu Tyr Lys

245 250 255Glu Lys Leu Gln Ser Ala Glu Glu Leu Leu Pro Leu Leu Arg Lys Pro

260 265 270His Tyr Ile Pro Glu Thr Val Ser Ala Lys Thr Ala Leu Tyr His Leu

275 280 285Ala Gly Glu Asp Cys Gly Leu Gly Ile Ile Ile Asp Glu Tyr Gly Ser

290 295 300Ile Glu Gly Leu Ile Thr Gln Asn Asp Leu Phe Lys Ile Val Ser Asp305 310 315 320Gly Val Ala His Asn Arg Pro Ser Phe Lys Gln Phe Ala His Ser Asp

325 330 335Lys Asn Val Val Ile Ala Ala Gly Thr Tyr Glu Leu Ser Asp Phe Tyr

340 345 350Asp Leu Phe Gly Val Asp Leu Pro Thr Thr Ala Asn Cys Val Thr Ile

355 360 365Gly Gly Trp Leu Thr Glu Gln Leu Gly Glu Ile Pro Glu Thr Gly Thr

370 375 380Lys Phe Ala Trp Gly Gln Phe Val Phe Gln Ile Leu Asp Ala Ala Pro385 390 395 400Asn Cys Val Lys Arg Val Tyr Ile Arg Lys Thr His Gly Asn

405 410<210>569<211>404<212>PRT<213>沙眼衣原体D血清变型<400>569Met Glu Thr Asn Ser Pro Phe Phe Trp Leu Gly Val Asn Leu Leu Cys1 5 10 15Ile Phe Val Gln Gly Phe Phe Ser Met Met Glu Met Ala Cys Ile Ser

20 25 30Phe Asn Arg Val Arg Leu Gln Tyr Tyr Leu Thr Lys Ser Asn Lys Lys

35 40 45Ala Ser Tyr Ile Asn Phe Leu Val Arg Arg Pro Tyr Arg Leu Phe Gly

50 55 60Thr Val Met Leu Gly Val Asn Ile Ala Leu Gln Ile Gly Ser Glu Ser65 70 75 80Ser Arg Thr Cys Tyr Lys Leu Leu Gly Ile Ser Pro Glu Tyr Ala Pro

85 90 95Ala Thr Gln Ile Ile Leu Val Val Ile Phe Ala Glu Leu Ile Pro Leu

100 105 110Ala Ile Ser Arg Lys Ile Pro Glu Lys Ile Ala Leu Lys Gly Ala Pro

115 120 125Ile Leu Tyr Phe Ala His Tyr Leu Phe Tyr Pro Leu Ile Gln Cys Val

130 135 140Gly Gly Ile Thr Asn Met Ile Tyr Phe Ile Leu Asn Ile Lys Glu Glu145 150 155 160Thr Leu His Ser Thr Leu Ser Arg Asp Glu Leu Gln Lys Thr Leu Glu

165 170 175Thr His His Glu Glu His Asp Phe Asn Val Ile Ala Thr Asn Ile Phe

180 185 190Ser Leu Ser Ala Thr Ser Val Glu Gln Val Cys Gln Tyr Leu Asp Gln

195 200 205Ile Pro Ile Leu Ser Ala Thr Ala Ser Val Arg Asp Val Cys Gln Leu

210 215 220Val Arg Arg His Arg Leu Asp Phe Val Pro Val Tyr His Lys Val Lys225 230 235 240Lys Asn Val Val Gly Ile Ala Phe Pro Lys Asn Leu Ile Asn Arg Asn

245 250 255Pro Ser Asp Pro Val Val Pro Tyr Leu Ser Ser Pro Trp Phe Ile Thr

260 265 270Ala Lys Ser Lys Leu Ile His Ala Ile Gln Glu Phe Arg Lys Asn Ser

275 280 285Ser Asn Val Ala Ile Val Leu Asn Asn Asn Gly Glu Pro Met Gly Val

290 295 300Leu Gly Leu His Thr Val Phe Lys Thr Leu Phe Asn Thr Arg Asn Ile305 310 315 320Ala Gln Leu Lys Pro Lys Pro Thr Ser Leu Ile Glu Arg Thr Phe Ser

325 330 335Gly Asn Thr Pro Leu Ser Glu Ile Glu Asn Glu Leu Asp Ile Ile Phe

340 345 350Met Asp Asn Asp Cys Thr Thr Ile Glu Gln Leu Met Leu Lys Leu Leu

355 360 365Asp Thr Pro Pro Glu Val Gly Ala Ser Ile Ile Ile Asn Asp Leu Leu

370 375 380Leu Glu Val Lys Glu Ile Ser Leu Tyr Gly Ile Lys Thr Val Ala Ile385 390 395 400Lys Asp Thr Leu<210>570<211>539<212>PRT<213>沙眼衣原体D血清变型<400>570Met Cys Cys Val Asp Gly Ser Asn Ser Ile Gln Gln Arg Met Arg Phe1 5 10 15Cys Glu Tyr Arg Thr Ala Ala Gln Glu Ala Lys Thr Ser Leu Ser Ser

20 25 30Asp Cys Ser Leu Leu Glu Ala Arg Leu Ala Leu Arg Ala Leu Ala Lys

35 40 45His His Glu Tyr Ser Ala Trp Arg Glu Ala Phe Leu Arg Ser Gln Glu

50 55 60Arg Phe Pro Ser Leu Glu Ala Asp Arg Asp Ile His Glu Asp Leu Ala65 70 75 80Ala Ser Leu Leu Gln Lys Asn Ile Arg His Ser Ser Leu Thr Val Arg

85 90 95Val Ile Thr Ile Leu Ala Val Gly Met Ala Arg Asp Tyr Arg Leu Val

100 105 110Pro Ile Val Leu Gln Ala Leu Ser Asp Asp Ser Asp Thr Val Arg Glu

115 120 125Ile Ala Val Gln Val Ala Val Met Tyr Gly Ser Ser Cys Leu Leu Arg

130 135 140Ala Val Gly Asp Leu Ala Lys Asn Asp Ser Ser Ile Gln Val Arg Ile145 150 155 160Thr Ala Tyr Arg Ala Ala Ala Val Leu Glu Ile Gln Asp Leu Val Pro

165 170 175His Leu Arg Val Val Val Gln Asn Thr Gln Leu Asp Gly Thr Glu Arg

180 185 190Arg Glu Ala Trp Arg Ser Leu Cys Val Leu Thr Arg Pro His Ser Gly

195 200 205Val Leu Thr Gly Ile Asp Gln Ala Leu Met Thr Cys Glu Met Leu Lys

210 215 220Glu Tyr Pro Glu Lys Cys Thr Glu Glu Gln Ile Arg Thr Leu Leu Ala225 230 235 240Ala Asp His Pro Glu Val Gln Val Ala Thr Leu Gln Ile Ile Leu Arg

245 250 255Gly Gly Arg Val Phe Arg Ser Ser Ser Ile Met Glu Ser Val Gln Lys

260 265 270Leu Ala Cys Asn Ser Leu Ser Ala Arg Val Gln Met Gln Ala Ala Ala

275 280 285Ile Leu Tyr Leu Glu Gly Asp Pro Phe Gly Glu Asp Lys Leu Thr Glu

290 295 300Gly Leu Ser Ala Thr Ser Ser Ile Leu Cys Glu Ala Ala Ser Glu Ala305 310 315 320Val Cys Ser Leu Gly Ile His Gly Val His Leu Ala Gly Arg Phe Leu

325 330 335Ser Lys Val Gln Gly Met Arg Ser Arg Val Asn Leu Ala Phe Ala Leu

340 345 350Leu Val Ser Arg Glu Lys Val Glu Glu Ala Gly Asp Val Val Ala Ser

355 360 365Phe Ile His Arg Ile Glu Pro Cys Arg Ala Ile Glu Gln Phe Leu Cys

370 375 380Glu Asp Gln Lys Ile Phe Val Ala Ser Ser Pro Leu Gln Val Glu Ile385 390 395 400Met Lys Arg Asp Leu Ala Lys Lys Ile Ile Arg Leu Leu Val Ala Ala

405 410 415Gln Tyr Ser Lys Ala Lys Met Val Val Ala Gln Tyr Leu Ala Gly Gln

420 425 430Gln Val Gly Trp Ser Phe Cys Ser Glu Val Phe Trp Glu Glu Gly Asp

435 440 445Ser Glu Asp Phe Val Glu Pro Leu Gln Glu Glu Ser Phe Ala Phe Ala

450 455 460Leu Glu Lys Ala Leu Ser Phe Leu Gln Arg Glu Gly Gly Glu Ala Gly465 470 475 480Leu His Ala Val Ile Ser Leu Tyr Pro His Ser Arg Trp Gln Asp Lys

485 490 495Leu Thr Ile Leu Glu Ala Ile Ala Tyr Ser Glu Asn Arg Ile Ala Thr

500 505 510Cys Phe Leu Arg Glu Arg Cys Leu Gln Glu Ala Ala Ser Leu Gln Ser

515 520 525Ala Ala Ala Gly Ala Val Phe Ala Leu Phe Lys

530 535<210>571<211>104<212>PRT<213>沙眼衣原体D血清变型<400>571Met Gln Thr Ser Arg Ile Ser Ser Phe Phe Arg Gly Leu Val His Leu1 5 10 15Tyr Arg Trp Ala Ile Ser Pro Phe Leu Gly Ala Pro Cys Arg Phe Phe

20 25 30Pro Thr Cys Ser Glu Tyr Ala Leu Val Ala Leu Lys Lys His Pro Leu

35 40 45Arg Lys Ser Leu Phe Leu Ile Ala Lys Arg Leu Leu Lys Cys Gly Pro

50 55 60Trp Cys Ile Gly Gly Ile Asp Leu Val Pro Arg Thr Ser Val Glu Glu65 70 75 80Tyr Leu Ser Ser Pro Thr Pro Leu Ala Glu Ser Pro Asp Asp Arg Thr

85 90 95Val Pro His Thr Gln Glu Thr Ser

100<210>572<211>336<212>PRT<213>沙眼衣原体D血清变型<400>572Met Gln Leu Phe Phe Gly Arg Phe Tyr Glu Val Ala Cys Ile Val Ala1 5 10 15Ser Ile Leu Arg Glu Arg Asp Val Gly Val Phe Met Gly Ile Glu Gly

20 25 30Arg Gly Ser Gly Ala Met Gln Ser Lys Lys Thr Ile Lys Trp Leu Lys

35 40 45Gln Ala Leu Val Leu Ser Ser Ile Val Asn Ile Leu Leu Leu Leu Leu

50 55 60Ile Tyr Ser Thr Val Phe Arg Lys Asp Ile Tyr Lys Leu Arg Val Phe65 70 75 80Pro Gly Asn Leu Ile Ala Lys Ser Ser Arg Ile Gly Lys Ile Pro Glu

85 90 95Asp Ile Leu Glu Arg Leu Glu Asn Ala Ser Phe Ala Asp Leu Leu Ala

100 105 110Leu Leu Gln Glu Glu Arg Met Val Phe Gly His Pro Leu Lys Ser Trp

115 120 125Ala Leu Gly Val Ser Ile Gln Lys Tyr Phe Val Asp Ile Ala Pro Met

130 135 140Leu Thr His Pro Leu Thr Phe Ile Arg Leu Lys Ser Pro Glu Arg Thr145 150 155 160Trp Leu Leu Pro Asp Ile Asn Asp Gln Glu Phe Thr Arg Ile Cys Gln

165 170 175Tyr Leu Leu Thr Glu Arg Phe Pro Phe Ser Ser Arg Gly Phe Phe Arg

180 185 190Ile Met Val Arg Asp Cys Glu Ala Gly Met Val Asp Glu Asp Val Leu

195 200 205Tyr Arg Phe Cys His Leu Pro Glu Phe Leu Tyr Val Arg Ser Leu Leu

210 215 220Phe Gly Ala Glu Ile Glu Ala Ala Ser Val Ala Ser Leu Ala Arg Met225 230 235 240Ile Ile Gln Gly Gly Glu Asp Leu Phe Phe Ser Leu Cys Cys Leu Glu

245 250 255Asn Arg Gln Thr Ala Ile Ser Asp His Gln Arg Arg Cys Phe Leu Lys

260 265 270Ala Tyr Val Asp Arg Gln Glu Pro Leu Ala Ala Leu Leu Leu Leu Val

275 280 285His Asp Ala Asp Trp Val Leu His Glu Phe Ser Asp Ser Asp Leu Gln

290 295 300Ser Phe Ile Gln Leu Leu Pro Arg Glu Ala His Tyr Thr Lys Lys Phe305 310 315 320Leu Gly Cys Val Ala Gln Ser Cys Arg Leu Gly Ile Leu Leu Glu Gly

325 330 335<210>573<211>426<212>PRT<213>沙眼衣原体D血清变型<400>573Met Tyr Val Arg Ser Ile Phe Phe Ser Ile Ile Ala Phe Leu Thr Val1 5 10 15Gly Cys Ser Phe Ser Pro Pro Glu Ser Gly Leu Ile Ile Ala Ile His

20 25 30Asp Asp Pro Arg Ser Leu Ser Pro Glu Lys Gly Glu Asn Ala Phe His

35 40 45Phe Ser Leu Ser Lys Ala Leu Phe Ala Thr Leu Phe Arg Glu Glu Leu

50 55 60Ser Gly Leu Thr Pro Ala Leu Val Ser Ser Tyr Gln Val Ser Glu Asp65 70 75 80Gly Arg Phe Tyr Arg Phe Cys Ile Arg Lys Asp Ala Lys Trp Ser Asp

85 90 95Gly Ser Leu Leu Leu Ala Glu Asp Val Ile Ala Ala Trp Glu His Thr

100 105 110Lys Gln Ala Gly Arg Tyr Ser Leu Leu Phe Glu Lys Leu Ser Phe Arg

115 120 125Ala Ser Ser Ser Ser Glu Ile Leu Ile Glu Leu Lys Glu Pro Glu Pro

130 135 140Gln Leu Leu Ala Ile Leu Ala Ser Pro Phe Phe Ala Val Tyr Arg Pro145 150 155 160Glu Asn Pro Phe Leu Ser Ser Gly Pro Phe Met Pro Lys Thr Tyr Val

165 170 175Gln Gly Gln Thr Leu Val Leu Gln Lys Asn Pro Tyr Tyr Tyr Asp His

180 185 190Ala His Val Glu Leu His Ser Ile Asp Phe Arg Ile Ile Pro Asn Ile

195 200 205Tyr Thr Ala Leu His Leu Leu Arg Arg Gly Asp Val Asp Trp Val Gly

210 215 220Gln Pro Trp His Gln Gly Ile Pro Phe Glu Leu Arg Thr Thr Ser Ala225 230 235 240Leu Tyr Thr His Tyr Ser Val Asp Gly Thr Phe Trp Leu Ile Leu Asn

245 250 255Pro Lys Asp Pro Val Leu Ser Ser Leu Ser Asn Arg Gln Arg Leu Ile

260 265 270Ala Ala Val Gln Lys Glu Lys Leu Val Lys Gln Ala Leu Gly Thr Gln

275 280 285Tyr Arg Val Ala Glu Ser Ser Pro Ser Pro Glu Gly Ile Ile Ala His

290 295 300Gln Glu Ala Ser Thr Pro Phe Pro Gly Lys Ile Thr Leu Ile Tyr Pro305 310 315 320Asn Asn Ile Thr Arg Cys Gln Arg Leu Ala Glu Val Leu Gln Glu Gln

325 330 335Cys Arg Asp Ala Gly Ile Gln Leu Thr Leu Glu Gly Leu Glu Tyr His

340 345 350Val Phe Val Gln Lys Arg Ala Thr Gln Asp Phe Ser Val Ser Thr Ala

355 360 365Thr Ser Ile Ala Phe His Pro Leu Ala Lys Ser Lys Phe Asp Gln Thr

370 375 380Ala Leu Asp Asn Phe Thr Cys Leu Pro Leu Tyr His Ile Glu Tyr Asp385 390 395 400Tyr Ile Leu Ser Arg Pro Leu Asp Gln Ile Val His Tyr Pro Ser Gly

405 410 415Ser Val Asp Leu Thr Tyr Ala His Phe His

420 425<210>574<211>605<212>PRT<213>沙眼衣原体D血清变型<400>574Met Gln Asn Ile Leu Arg Thr Ser Ser Cys Arg Tyr Met Phe Leu Leu1 5 10 15Gly Ile Arg Ser Val Trp Asn Arg Val Ala Val Val Asn Asn Phe Arg

20 25 30Gly Ser Ser Trp Lys Ile Val Ala Ile Pro Ser Cys Ile Leu Phe Thr

35 40 45Leu Ile Phe His Leu Pro Arg Trp Leu Ile Asp Phe Gly Val Cys Thr

50 55 60Asn Leu Ala Cys Ser Leu Ser Ile Ile Phe Trp Val Phe Ser Leu Arg65 70 75 80Ser Ser Ala Ser Ala Arg Ile Phe Pro Ser Leu Leu Leu Tyr Leu Cys

85 90 95Leu Leu Arg Leu Gly Leu Asn Leu Ala Ser Thr Arg Trp Ile Leu Ser

100 105 110Ser Gly Trp Ala Ser Pro Leu Ile Phe Ala Leu Gly Asn Phe Phe Ser

115 120 125Leu Gly Ser Ile Pro Val Ala Leu Thr Val Cys Leu Leu Leu Phe Leu

130 135 140Val Asn Phe Leu Val Ile Thr Lys Gly Ala Glu Arg Ile Ala Glu Val145 150 155 160Arg Ala Arg Phe Ser Leu Glu Ala Leu Pro Gly Lys Gln Met Ser Leu

165 170 175Asp Ala Asp Ile Ala Ala Gly Arg Ile Gly Tyr Ser Arg Ala Ser Val

180 185 190Lys Lys Ser Ser Leu Leu Glu Glu Ser Asp Tyr Phe Ser Ala Met Glu

195 200 205Gly Val Phe Arg Phe Val Lys Gly Asp Ala Ile Met Ser Trp Val Leu

210 215 220Leu Gly Val Asn Ile Leu Ala Ala Leu Phe Leu Gly Arg Ala Thr His225 230 235 240Val Gly Asp Leu Trp Leu Thr Val Leu Gly Asp Ala Leu Val Ser Gln

245 250 255Ile Pro Ala Leu Leu Thr Ser Cys Ala Ala Ala Thr Leu Ile Ala Lys

260 265 270Val Gly Glu Lys Glu Ser Leu Ala Gln His Leu Leu Asp Tyr Tyr Glu

275 280 285Gln Ser Arg Gln Ser Phe Leu Phe Ile Ala Leu Ile Leu Cys Gly Met

290 295 300Ala Cys Ile Pro Gly Ala Pro Lys Ala Leu Ile Leu Gly Phe Ser Val305 310 315 320Leu Leu Phe Leu Gly Tyr Lys Asn Pro Ser Ser Gly Glu Thr Leu Leu

325 330 335Phe Gln Lys Glu Arg Val Glu Phe Val Leu Pro Asp Glu Gly Val Gly

340 345 350Asn Pro Ala Asn Leu Tyr Lys Asp Ala Arg Asn Gln Ile Tyr Gln Glu

355 360 365Leu Gly Val Val Phe Pro Glu Ala Ile Val Val Arg His Val Thr Gly

370 375 380Ser Ser Pro Arg Leu Ile Phe Ser Gly Gln Glu Val Ala Leu Arg Glu385 390 395 400Leu Ser Cys Pro Ala Ile Leu Glu Ser Ile Arg Gln Leu Ala Pro Glu

405 410 415Thr Ile Ser Glu Arg Phe Val Thr Arg Leu Val Asp Glu Phe Arg Glu

420 425 430His Ala Phe Leu Ser Ile Glu Glu Ile Leu Pro Leu Lys Ile Ser Glu

435 440 445Asn Ser Leu Ile Phe Leu Leu Arg Ala Leu Val Arg Glu Arg Val Ser

450 455 460Leu His Leu Phe Pro Lys Ile Leu Glu Ala Ile Asp Val Tyr Gly Ser465 470 475 480Gln Pro Lys Asn Ser Gln Glu Leu Val Glu Cys Val Arg Lys Tyr Leu

485 490 495Gly Lys Gln Ile Gly Leu Ser Leu Trp Asn Arg Gln Asp Val Leu Glu

500 505 510Val Ile Thr Ile Asp Ser Leu Val Glu Gln Phe Val Arg Asp Ser Gln

515 520 525Glu Lys Val Val Leu Asp Leu Asn Glu Lys Val Val Ala Gln Val Lys

530 535 540His Leu Leu Arg Val Gly Glu Gly Asn Phe Arg Ala Ile Val Thr Gly545 550 555 560Ser Glu Thr Arg Lys Glu Leu Lys Arg Ile Val Asp Pro Tyr Phe Pro

565 570 575Asp Leu Leu Val Leu Ala His Ser Glu Leu Pro Glu Glu Ile Pro Ile

580 585 590Thr Leu Leu Gly Ala Val Ser Asp Glu Val Leu Leu Ser

595 600 605<210>575<211>173<212>PRT<213>沙眼衣原体D血清变型<400>575Met Lys Lys Phe Leu Leu Leu Ser Leu Met Ser Leu Ser Ser Leu Pro1 5 10 15Thr Phe Ala Ala Asn Ser Thr Gly Thr Ile Gly Ile Val Asn Leu Arg

20 25 30Arg Cys Leu Glu Glu Ser Ala Leu Gly Lys Lys Glu Ser Ala Glu Phe

35 40 45Glu Lys Met Lys Asn Gln Phe Ser Asn Ser Met Gly Lys Met Glu Glu

50 55 60Glu Leu Ser Ser Ile Tyr Ser Lys Leu Gln Asp Asp Asp Tyr Met Glu65 70 75 80Gly Leu Ser Glu Thr Ala Ala Ala Glu Leu Arg Lys Lys Phe Glu Asp

85 90 95Leu Ser Ala Glu Tyr Asn Thr Ala Gln Gly Gln Tyr Tyr Gln Ile Leu

100 105 110Asn Gln Ser Asn Leu Lys Arg Met Gln Lys Ile Met Glu Glu Val Lys

115 120 125Lys Ala Ser Glu Thr Val Arg Ile Gln Glu Gly Leu Ser Val Leu Leu

130 135 140Asn Glu Asp Ile Val Leu Ser Ile Asp Ser Ser Ala Asp Lys Thr Asp145 150 155 160Ala Val Ile Lys Val Leu Asp Asp Ser Phe Gln Asn Asn

165 170<210>576<211>354<212>PRT<213>沙眼衣原体D血清变型<400>576Met Ser Gln Ser Thr Tyr Ser Leu Glu Gln Leu Ala Asp Phe Leu Lys1 5 10 15Val Glu Phe Gln Gly Asn Gly Ala Thr Leu Leu Ser Gly Val Glu Glu

20 25 30Ile Glu Glu Ala Lys Thr Ala HIs Ile Thr Phe Leu Asp Asn Glu Lys

35 40 45Tyr Ala Lys His Leu Lys Ser Ser Glu Ala Gly Ala Ile Ile Ile Ser

50 55 60Arg Thr Gln Phe Gln Lys Tyr Arg Asp Leu Asn Lys Asn Phe Leu Ile65 70 75 80Thr Ser Glu Ser Pro Ser Leu Val Phe Gln Lys Cys Leu Glu Leu Phe

85 90 95Ile Thr Pro Val Asp Ser Gly Phe Pro Gly Ile His Pro Thr Ala Val

100 105 110Ile His Pro Thr Ala Ile Ile Glu Asp His Val Cys Ile Glu Pro Tyr

115 120 125Ala Val Val Cys Gln His Ala His Val Gly Ser Ala Cys His Ile Gly

130 135 140Ser Gly Ser Val Ile Gly Ala Tyr Ser Thr Val Gly Glu His Ser Tyr145 150 155 160Ile His Pro Arg Val Val Ile Arg Glu Arg Val Ser Ile Gly Lys Arg

165 170 175Val Ile Ile Gln Pro Gly Ala Val Ile Gly Ser Cys Gly Phe Gly Tyr

180 185 190Val Thr Ser Ala Phe Gly Gln His Lys His Leu Lys His Leu Gly Lys

195 200 205Val Ile Ile Glu Asp Asp Val Glu Ile Gly Ala Asn Thr Thr Ile Asp

2l0 215 220Arg Gly Arg Phe Lys His Ser Val Val Arg Glu Gly Ser Lys Ile Asp225 230 235 240Asn Leu Val Gln Ile Ala His Gln Val Glu Val Gly Gln His Ser Met

245 250 255Ile Val Ala Gln Ala Gly Ile Ala Gly Ser Thr Lys Ile Gly Asn His

260 265 270Val Ile Ile Gly Gly Gln Ala Gly Ile Thr Gly His Ile Cys Ile Ala

275 280 285Asp His Val Ile Met Met Ala Gln Thr Gly Val Thr Lys Ser Ile Thr

290 295 300Ser Pro Gly Ile Tyr Gly Gly Ala Pro Ala Arg Pro Tyr Gln Glu Ile305 310 315 320His Arg Gln Val Ala Lys Val Arg Asn Leu Pro Arg Leu Glu Glu Arg

325 330 335Ile Ala Ala Leu Glu Lys Leu Val Gln Lys Leu Glu Ala Leu Ser Glu

340 345 350Gln His<210>577<211>421<212>PRT<213>沙眼衣原体D血清变型<400>577Met Thr Ala Ser Gly Gly Ala Gly Gly Leu Gly Ser Thr Gln Thr Val1 5 10 15Asp Val Ala Arg Ala Gln Ala Ala Ala Ala Thr Gln Asp Ala Gln Glu

20 25 30Val Ile Gly Ser Gln Glu ALa Ser Glu Ala Ser Met Leu Lys Gly Cys

35 40 45Glu Asp Leu Ile Asn Pro Ala Ala Ala Thr Arg Ile Lys Lys Lys Gly

50 55 60Glu Lys Phe Glu Ser Leu Glu Ala Arg Arg Lys Pro Thr Ala Asp Lys65 70 75 80Ala Glu Lys Lys Ser Glu Ser Thr Glu Glu Lys Gly Asp Thr Pro Leu

85 90 95Glu Asp Arg Phe Thr Glu Asp Leu Ser Glu Val Ser Gly Glu Asp Phe

100 105 110Arg Gly Leu Lys Asn Ser Phe Asp Asp Asp Ser Ser Pro Asp Glu Ile

115 120 125Leu Asp Ala Leu Thr Ser Lys Phe Ser Asp Pro Thr Ile Lys Asp Leu

130 135 140Ala Leu Asp Tyr Leu Ile Gln Thr Ala Pro Ser Asp Gly Lys Leu Lys145 150 155 160Ser Thr Leu Ile Gln Ala Lys His Gln Leu Met Ser Gln Asn Pro Gln

165 170 175Ala Ile Val Gly Gly Arg Asn Val Leu Leu Ala Ser Glu Thr Phe Ala

180 185 190Ser Arg Ala Asn Thr Ser Pro Ser Ser Leu Arg Ser Leu Tyr Phe Gln

195 200 205Val Thr Ser Ser Pro Ser Asn Cys Ala Asn Leu His Gln Met Leu Ala

210 215 220Ser Tyr Leu Pro Ser Glu Lys Thr Ala Val Met Glu Phe Leu Val Asn225 230 235 240Gly Met Val Ala Asp Leu Lys Ser Glu Gly Pro Ser Ile Pro Pro Ala

245 250 255Lys Leu Gln Val Tyr Met Thr Glu Leu Ser Asn Leu Gln Ala Leu His

260 265 270Ser Val Asn Ser Phe Phe Asp Arg Asn Ile Gly Asn Leu Glu Asn Ser

275 280 285Leu Lys His Glu Gly His Ala Pro Ile Pro Ser Leu Thr Thr Gly Asn

290 295 300Leu Thr Lys Thr Phe Leu Gln Leu Val Glu Asp Lys Phe Pro Ser Ser305 310 315 320Ser Lys Ala Gln Lys Ala Leu Asn Glu Leu Val Gly Pro Asp Thr Gly

325 330 335Pro Gln Thr Glu Val Leu Asn Leu Phe Phe Arg Ala Leu Asn Gly Cys

340 345 350Ser Pro Arg Ile Phe Ser Gly Ala Glu Lys Lys Gln Gln Leu Ala Ser

355 360 365Val Ile Thr Asn Thr Leu Asp Ala Ile Asn Ala Asp Asn Glu Asp Tyr

370 375 380Pro Lys Pro Gly Asp Phe Pro Arg Ser Ser Phe Ser Ser Thr Pro Pro385 390 395 400His Ala Pro Val Pro Gln Ser Glu Ile Pro Thr Ser Pro Thr Ser Thr

405 410 415Gln Pro Pro Ser Pro

420<210>578<211>231<212>PRT<213>沙眼衣原体D血清变型<400>578Met Met Glu Val Phe Met Asn Phe Leu Asp Gln Leu Asp Leu Ile Ile1 5 10 15Gln Asn Lys His Met Leu Glu His Thr Phe Tyr Val Lys Trp Ser Lys

20 25 30Gly Glu Leu Thr Lys Glu Gln Leu Gln Ala Tyr Ala Lys Asp Tyr Tyr

35 40 45Leu His Ile Lys Ala Phe Pro Lys Tyr Leu Ser Ala Ile His Ser Arg

85 90 95Phe Ala Leu Gly Val Thr Pro Glu Glu Leu Glu Ala His Glu Pro Ser

100 105 110Glu Ala Ala Lys Ala Lys Val Ala Thr Phe Met Arg Trp Cys Thr Gly

115 120 125Asp Ser Leu Ala Ala Gly Val Ala Ala Leu Tyr Ser Tyr Glu Ser Gln

165 170 175Ala Asp Val Arg His Ala Arg Glu Glu Lys Ala Leu Ile Glu Met Leu

180 185 190Leu Lys Asp Asp Ala Asp Lys Val Leu Glu Ala Ser Gln Glu Val Thr

195 200 205Gln Ser Leu Tyr Gly Phe Leu Asp Ser Phe Leu Asp Pro Gly Thr Cys

210 215 220Cys Ser Cys His Gln Ser Tyr225 230<210>579<211>243<212>PRT<213>沙眼衣原体D血清变型<400>579Met Lys Ile Thr Pro Ile Lys Thr Arg Lys Val Phe Ala His Asp Ser1 5 10 15Leu Gln Glu Ile Leu Gln Glu Ala Leu Pro Pro Leu Gln Glu Arg Ser

20 25 30Val Val Val Val Ser Ser Lys Ile Val Ser Leu Cys Glu Gly Ala Val

35 40 45Ala Asp Ala Arg Met Cys Lys Ala Glu Leu Ile Lys Lys Glu Ala Asp

50 55 60Ala Tyr Leu Phe Cys Glu Lys Ser Gly Ile Tyr Leu Thr Lys Lys Glu65 70 75 80Gly Ile Leu Ile Pro Ser Ala Gly Ile Asp Glu Ser Asn Thr Asp Gln

85 90 95pro Phe Val Leu Tyr Pro Lys Asp Ile Leu Gly Ser Cys Asn Arg Ile

100 105 110Gly Glu Trp Leu Arg Asn Tyr Phe Arg Val Lys Glu Leu Gly Val Ile

115 120 125Ile Thr Asp Ser His Thr Thr Pro Met Arg Arg Gly Val Leu Gly Ile

130 135 140Gly Leu Cys Trp Tyr Gly Phe Ser Pro Leu His Asn Tyr Ile Gly Ser145 150 155 160Leu Asp Cys Phe Gly Arg Pro Leu Gln Met Thr Gln Ser Asn Leu Val

165 170 175Asp Ala Leu Ala Val Ala Ala Val Val Cys Met Gly Glu Gly Asn Glu

180 185 190Gln Thr Pro Leu Ala Val Ile Glu Gln Ala Pro Asn Met Val Tyr His

195 200 205Ser His Pro Thr Ser Arg Glu Glu Tyr Cys Ser Leu Arg Ile Asp Glu

210 215 220Thr Glu Asp Leu Tyr Gly Pro Phe Leu Gln Ala Val Thr Trp Ser Gln225 230 235 240Glu Lys Lys<210>580<211>383<212>PRT<213>沙眼衣原体D血清变型<400>580Met Leu Pro His Gln Gln Asn Ser Ser Ser Glu Arg Ala Arg His His1 5 10 15Glu Ser Arg Ser His Arg His Ser Ser Ser Ser Arg His His Val Thr

20 25 30Arg Ser Gln Ser Ser Ala Leu Pro Gln Leu Gln Glu Arg Pro Val Pro

35 40 45His Pro Leu Ala Glu Arg Glu Leu Ile Ile Phe His Ser Val His Gln

50 55 60Gln Gln Asn Asn Asn Pro Leu Arg Met Ile Cys Asp Thr Ile Arg Gln65 70 75 80Ala Gln Arg Gly Ile Phe Met Arg Ile Tyr Thr Ile Ser Ser Asp Asp

85 90 95Ile Ile Gln Ser Leu Ile Gln Thr Ser His His Val Pro Val Glu Val

100 105 110Lys Tyr His Cys Gly Glu Ser Leu Pro Val Ala Cys Gln Asn Ser Arg

115 120 125Val Val Leu Arg Leu Thr Asn Gly Arg Thr Leu Gln His Lys Lys Thr

130 135 140Met Leu Ala Asp Phe Gln Thr Val Val Thr Gly Ser Ala Asn Tyr Thr145 150 155 160Asp Leu Ser Leu Asn His Asp Ala Asn Val Thr Ala Cys Ile Glu Ser

165 170 175Ser Glu Leu His Asp Ala Val Phe Ser Glu Arg Pro Gln Leu Val His

180 185 190Val Gly Pro Gln Leu Leu Asn Tyr Ile Pro Ile Gln Arg Leu Ile Pro

195 200 205Asn Ala Ala Ser Lys Met Ile Leu Asn Ala Ile Asn Gln Ala Thr Asp

210 215 220Ser Ile Phe Val Leu Met Tyr Ile Phe Leu Ser Pro Glu Phe Phe Leu225 230 235 240Ala Leu Ala Gln Ala Met Arg Arg Gly Val Arg Val Lys Val Ile Ile

245 250 255Asp Asn His Ser Lys Gln Asp Thr Cys Lys Leu Leu Ser Lys Leu Gly

260 265 270Ile Gln Leu Pro Ile Tyr Glu Arg Lys Thr Glu Gly Val Leu His Thr

275 280 285Lys Ile Cys Cys Ile Asp Asn Lys Thr Leu Ile Phe Gly Ser Ala Asn

290 295 300Trp Ser Gly Ala Gly Met Ile Lys Asn Phe Glu Asp Leu Phe Ile Leu305 310 315 320Arg Pro Ile Thr Glu Thr Gln Leu Gln Ala Phe Met Asp Val Trp Ser

325 330 335Leu Leu Glu Thr Asn Ser Ser Tyr Leu Ser Pro Glu Ser Val Leu Thr

340 345 350Ala Pro Thr Pro Ser Ser Arg Pro Thr Gln Gln Asp Thr Asp Ser Asp

355 360 365Asp Glu Gln Pro Ser Thr Ser Gln Gln Asp Ile Arg Met Arg Lys

370 375 380<210>581<211>193<212>PRT<213>沙眼衣原体D血清变型<400>581Met Trp Phe Phe Leu Gly Ser Pro Ser Ala Ile Thr Asn Phe Ser Arg1 5 10 15Val Asp Val Ala Leu Asn Leu Arg Ile Asn Arg Gln Ile Arg Ala Pro

20 25 30Arg Val Arg Val Ile Gly Ser Ala Gly Glu Gln Leu Gly Ile Leu Ser

35 40 45Ile Lys Glu Ala Leu Asp Leu Ala Lys Glu Ala Asn Leu Asp Leu Val

50 55 60Glu Val Ala Ser Asn Ser Glu Pro Pro Val Cys Lys Ile Met Asp Tyr65 70 75 80Gly Lys Tyr Arg Tyr Asp Val Thr Lys Lys Glu Lys Asp Ser Lys Lys

85 90 95Ala Gln His Gln Val Arg Ile Lys Glu Val Lys Leu Lys Pro Asn Ile

100 105 110Asp Asp Asn Asp Phe Leu Thr Lys Ala Lys Gln Ala Arg Ala Phe Ile

115 120 125Glu Lys Gly Asn Lys Val Lys Val Ser Cys Met Phe Arg Gly Arg Glu

130 135 140Leu Ala Tyr Pro Glu His Gly Tyr Lys Val Ile Gln Arg Met Cys Gln145 150 155 160Gly Leu Glu Asp Ile Gly Phe Val Glu Ser Glu Pro Lys Leu Asn Gly

165 170 175Arg Ser Leu Ile Cys Val Ile Ala Pro Gly Thr Leu Lys Thr Lys Lys

180 185 190Lys<210>582<211>264<212>PRT<213>沙眼衣原体D血清变型<400>582Met Gly Asn Ser Gly Phe Tyr Leu Tyr Asn Thr Glu Asn Cys Val Phe 1 5 10 15Ala Asp Asn Ile Lys Val Gly Gln Met Thr Glu Pro Leu Lys Asp Gln

20 25 30Gln Ile Ile Leu Gly Thr Lys Ser Thr Pro Val Ala Ala Lys Met Thr

35 40 45Ala Ser Asp Gly Ile Ser Leu Thr Val Ser Asn Asn Ser Ser Thr Asn

50 55 60Ala Ser Ile Thr Ile Gly Leu Asp Ala Glu Lys Ala Tyr Gln Leu Ile65 70 75 80Leu Glu Lys Leu Gly Asn Gln Ile Leu Asp Gly Ile Ala Asp Thr Ile

85 90 95Val Asp Ser Thr Val Gln Asp Ile Leu Asp Lys Ile Thr Thr Asp Pro

100 105 110Ser Leu Gly Leu Leu Lys Ala Phe Asn Asn Phe Pro Ile Thr Asn Lys

115 120 125Ile Gln Cys Asn Gly Leu Phe Thr Pro Ser Asn Ile Glu Thr Leu Leu

165 170 175Gly Val Val Leu Ala Leu Val Arg Glu Gly Asp Ser Lys Pro Cys Ala

180 185 190Ile Ser Tyr Gly Tyr Ser Ser Gly Val Pro Asn Leu Cys Ser Leu Arg

195 200 205Thr Ser Ile Thr Asn Thr Gly Leu Thr Pro Thr Thr Tyr Ser Leu Arg

245 250 255Glu Val Ile Pro Gln Thr Asn Ala

260<210>583<211>1053<212>PRT<213>沙眼衣原体D血清变型<400>583Met Phe Thr Arg Ile Val Met Val Asp Leu Gln Glu Lys Gln Cys Thr1 5 10 15Ile Val Lys Arg Asn Gly Met Phe Val Pro Phe Asp Arg Asn Arg Ile

20 25 30Phe Gln Ala Leu Glu Ala Ala Phe Arg Asp Thr Arg Arg Ile Asp Asp

35 40 45His Met Pro Leu Pro Glu Asp Leu Glu Ser Ser Ile Arg Ser Ile Thr

50 55 60His Gln Val Val Lys Glu Val Val Gln Lys Ile Thr Asp Gly Gln Val65 70 75 80Val Thr Val Glu Arg Ile Gln Asp Met Val Glu Ser Gln Leu Tyr Val

85 90 95Asn Gly Leu Gln Asp Val Ala Arg Asp Tyr Ile Val Tyr Arg Asp Asp

100 105 110Arg Lys Ala His Arg Lys Lys Ser Trp Gln Ser Leu Ser Val Val Arg

115 120 125Arg Cys Gly Thr Val Val His Phe Asn Pro Met Lys Ile Ser Ala Ala

130 135 140Leu Glu Lys Ala Phe Arg Ala Thr Asp Lys Thr Glu Gly Met Thr Pro145 150 155 160Ser Ser Val Arg Glu Glu Ile Asn Ala Leu Thr Gln Asn Ile Val Ala

165 170 175Glu Ile Glu Glu Cys Cys Pro Gln Gln Asp Arg Arg Ile Asp Ile Glu

180 185 190Lys Ile Gln Asp Ile Val Glu Gln Gln Leu Met Val Val Gly His Tyr

195 200 205Ala Val Ala Lys Asn Tyr Ile Leu Tyr Arg Glu Ala Arg Ala Arg Val

210 215 220Arg Asp Asn Arg Glu Glu Asp Gly Ser Thr Glu Lys Thr Ile Ala Glu225 230 235 240Glu Ala Val Glu Val Leu Ser Lys Asp Gly Ser Thr Tyr Thr Met Thr

245 250 255His Ser Gln Leu Leu Ala His Leu Ala Arg Ala Cys Ser Arg Phe Pro

260 265 270Glu Thr Thr Asp Ala Ala Leu Leu Thr Asp Met Ala Phe Ala Asn Phe

275 280 285Tyr Ser Gly Ile Lys Glu Ser Glu Val Val Leu Ala Cys Ile Met Ala

290 295 300Ala Arg Ala Asn Ile Glu Lys Glu Pro Asp Tyr Ala Phe Val Ala Ala305 310 315 320Glu Leu Leu Leu Asp Val Val Tyr Lys Glu Ala Leu Gly Lys Ser Lys

325 330 335Tyr Ala Glu Asp Leu Glu Gln Ala His Arg Asp His Phe Lys Arg Tyr

340 345 350Ile Ala Glu Gly Asp Thr Tyr Arg Leu Asn Ala Glu Leu Lys His Leu

355 360 365Phe Asp Leu Asp Ala Leu Ala Asp Ala Met Asp Leu Ser Arg Asp Leu

370 375 380Gln Phe Ser Tyr Met Gly Ile Gln Asn Leu Tyr Asp Arg Tyr Phe Asn385 390 395 400His His Glu Gly Cys Arg Leu Glu Thr Pro Gln Ile Phe Trp Met Arg

405 410 415Val Ala Met Gly Leu Ala Leu Asn Glu Gln Asp Lys Thr Ser Trp Ala

420 425 430Ile Thr Phe Tyr Asn Leu Leu Ser Thr Phe Arg Tyr Thr Pro Ala Thr

435 440 445Pro Thr Leu Phe Asn Ser Gly Met Arg His Ser Gln Leu Ser Ser Cys

450 455 460Tyr Leu Ser Thr Val Gln Asp Asn Leu Val Asn Ile Tyr Lys Val Ile465 470 475 480Ala Asp Asn Ala Met Leu Ser Lys Trp Ala Gly Gly Ile Gly Asn Asp

485 490 495Trp Thr Ala Ile Arg Ala Thr Gly Ala Leu Ile Lys Gly Thr Asn Gly

500 505 510Arg Ser Gln Gly Val Ile Pro Phe Ile Lys Val Thr Asn Asp Thr Ala

515 520 525Val Ala Val Asn Gln Gly Gly Lys Arg Lys Gly Ala Val Cys Val Tyr

530 535 540Leu Glu Val Trp His Leu Asp Tyr Glu Asp Phe Leu Glu Leu Arg Lys545 550 555 560Asn Thr Gly Asp Glu Arg Arg Arg Ala His Asp Val Asn Ile Ala Ser

565 570 575Trp Ile Pro Asp Leu Phe Phe Lys Arg Leu Gln Gln Lys Gly Thr Trp

580 585 590Thr Leu Phe Ser Pro Asp Asp Val Pro Gly Leu His Asp Ala Tyr Gly

595 600 605Glu Glu Phe Glu Arg Leu Tyr Glu Glu Tyr Glu Arg Lys Val Asp Thr

610 615 620Gly Glu Ile Arg Leu Phe Lys Lys Val Glu Ala Glu Asp Leu Trp Arg625 630 635 640Lys Met Leu Ser Met Leu Phe Glu Thr Gly His Pro Trp Met Thr Phe

645 650 655Lys Asp Pro Ser Asn Ile Arg Ser Ala Gln Asp His Lys Gly Val Val

660 665 670Arg Cys Ser Asn Leu Cys Thr Glu Ile Leu Leu Asn Cys Ser Glu Thr

675 680 685Glu Thr Ala Val Cys Asn Leu Gly Ser Ile Asn Leu Val Gln His Ile

690 695 700Val Gly Asp Gly Leu Asp Glu Glu Lys Leu Ser Glu Thr Ile Ser Ile705 710 715 720Ala Val Arg Met Leu Asp Asn Val Ile Asp Ile Asn Phe Tyr Pro Thr

725 730 735Lys Glu Ala Lys Glu Ala Asn Phe Ala His Arg Ala Ile Gly Leu Gly

740 745 750Val Met Gly Phe Gln Asp Ala Leu Tyr Lys Leu Asp Ile Ser Tyr Ala

755 760 765Ser Gln Glu Ala Val Glu Phe Ala Asp Tyr Ser Ser Glu Leu Ile Ser

770 775 780Tyr Tyr Ala Ile Gln Ala Ser Cys Leu Leu Ala Lys Glu Arg Gly Thr785 790 795 800Tyr Ser Ser Tyr Lys Gly Ser Lys Trp Asp Arg Gly Leu Leu Pro Ile

805 810 815Asp Thr Ile Gln Leu Leu Ala Asn Tyr Arg Gly Glu Ala Asn Leu Gln

820 825 830Met Asp Thr Ser Ser Arg Lys Asp Trp Glu Pro Ile Arg Ser Leu Val

835 840 845Lys Glu His Gly Met Arg His Cys Gln Leu Met Ala Ile Ala Pro Thr

850 855 860Ala Thr Ile Ser Asn Ile Ile Gly Val Thr Gln Ser Ile Glu Pro Thr865 870 875 880Tyr Lys His Leu Phe Val Lys Ser Asn Leu Ser Gly Glu Phe Thr Ile

885 890 895Pro Asn Val Tyr Leu Ile Glu Lys Leu Lys Lys Leu Gly Ile Trp Asp

900 905 910Ala Asp Met Leu Asp Asp Leu Lys Tyr Phe Asp Gly Ser Leu Leu Glu

915 920 925Ile Glu Arg Ile Pro Asp His Leu Lys His Ile Phe Leu Thr Ala Phe

930 935 940Glu Ile Glu Pro Glu Trp Ile Ile Glu Cys Ala Ser Arg Arg Gln Lys945 950 955 960Trp Ile Asp Met Gly Gln Ser Leu Asn Leu Tyr Leu Ala Gln Pro Asp

965 970 975Gly Lys Lys Leu Ser Asn Met Tyr Leu Thr Ala Trp Lys Lys Gly Leu

980 985 990Lys Thr Thr Tyr Tyr Leu Arg Ser Ser Ser Ala Thr Thr Val Glu Lys

995 1000 1005Ser Phe Val Asp Ile Asn Lys Arg Gly Ile Gln Pro Arg Trp Met Lys

1010 1015 1020Asn Lys Ser Ala Ser Ala Gly Ile Ile Val Glu Arg Ala Lys Lys Ala1025 1030 1035 1040Pro Val Cys Ser Leu Glu Glu Gly Cys Glu Ala Cys Gln

1045 1050<210>584<211>346<212>PRT<213>沙眼衣原体D血清变型<400>584Met Gln Ala Asp Ile Leu Asp Gly Lys Gln Lys Arg Val Asn Leu Asn1 5 10 15Ser Lys Arg Leu Val Asn Cys Asn Gln Val Asp Val Asn Gln Leu Val

20 25 30Pro Ile Lys Tyr Lys Trp Ala Trp Glu His Tyr Leu Asn Gly Cys Ala

35 40 45Asn Asn Trp Leu Pro Thr Glu Ile Pro Met Gly Lys Asp Ile Glu Leu

50 55 60Trp Lys Ser Asp Arg Leu Ser Glu Asp Glu Arg Arg Val Ile Leu Leu65 70 75 80Asn Leu Gly Phe Phe Ser Thr Ala Glu Ser Leu Val Gly Asn Asn Ile

85 90 95Val Leu Ala Ile Phe Lys His Val Thr Asn Pro Glu Ala Arg Gln Tyr

100 105 110Leu Leu Arg Gln Ala Phe Glu Glu Ala Val His Thr His Thr Phe Leu

115 120 125Tyr Ile Cys Glu Ser Leu Gly Leu Asp Glu Lys Glu Ile Phe Asn Ala

130 135 140Tyr Asn Glu Arg Ala Ala Ile Lys Ala Lys Asp Asp Phe Gln Met Glu145 150 155 160Ile Thr Gly Lys Val Leu Asp Pro Asn Phe Arg Thr Asp Ser Val Glu

165 170 175Gly Leu Gln Glu Phe Val Lys Asn Leu Val Gly Tyr Tyr Ile Ile Met

180 185 190Glu Gly Ile Phe Phe Tyr Ser Gly Phe Val Met Ile Leu Ser Phe His

195 200 205Arg Gln Asn Lys Met Ile Gly Ile Gly Glu Gln Tyr Gln Tyr Ile Leu

2l0 215 220Arg Asp Glu Thr Ile His Leu Asn Phe Gly Ile Asp Leu Ile Asn Gly225 230 235 240Ile Lys Glu Glu Asn Pro Glu Ile Trp Thr Pro Glu Leu Gln Gln Glu

245 250 255Ile Val Glu Leu Ile Lys Arg Ala Val Asp Leu Glu Ile Glu Tyr Ala

260 265 270Gln Asp Cys Leu Pro Arg Gly Ile Leu Gly Leu Arg Ala Ser Met Phe

275 280 285Ile Asp Tyr Val Gln His Ile Ala Asp Arg Arg Leu Glu Arg Ile Gly

290 295 300Leu Lys Pro Ile Tyr His Thr Lys Asn Pro Phe Pro Trp Met Ser Glu305 310 315 320Thr Ile Asp Leu Asn Lys Glu Lys Asn Phe Phe Glu Thr Arg Val Ile

325 330 335Glu Tyr Gln His Ala Ala Ser Leu Thr Trp

340 345<210>585<211>326<212>PRT<213>沙眼衣原体D血清变型<400>585Met Ser Phe Phe His Thr Arg Lys Tyr Lys Leu Ile Leu Arg Gly Leu1 5 10 15Leu Cys Leu Ala Gly Cys Phe Leu Met Asn Ser Cys Ser Ser Ser Arg

20 25 30Gly Asn Gln Pro Ala Asp Glu Ser Ile Tyr Val Leu Ser Met Asn Arg

35 40 45Met Ile Cys Asp Cys Val Ser Arg Ile Thr Gly Asp Arg Val Lys Asn

50 55 60Ile Val Leu Ile Asp Gly Ala Ile Asp Pro His Ser Tyr Glu Met Val65 70 75 80Lys Gly Asp Glu Asp Arg Met Ala Met Ser Gln Leu Ile Phe Cys Asn

85 90 95Gly Leu Gly Leu Glu His Ser Ala Ser Leu Arg Lys His Leu Glu Gly

100 105 110Asn Pro Lys Val Val Asp Leu Gly Gln Arg Leu Leu Asn Lys Asn Cys

115 120 125Phe Asp Leu Leu Ser Glu Glu Gly Phe Pro Asp Pro His Ile Trp Thr

130 135 140Asp Met Arg Val Trp Gly Ala Ala Val Lys Glu Met Ala Ala Ala Leu145 150 155 160Ile Gln Gln Phe Pro Gln Tyr Glu Glu Asp Phe Gln Lys Asn Ala Asp

165 170 175Gln Ile Leu Ser Glu Met Glu Glu Leu Asp Arg Trp Ala Ala Arg Ser

180 185 190Leu Ser Thr Ile Pro Glu Lys Asn Arg Tyr Leu Val Thr Gly His Asn

195 200 205Ala Phe Ser Tyr Phe Thr Arg Arg Tyr Leu Ser Ser Asp Ala Glu Arg

210 215 220Val Ser Gly Glu Trp Arg Ser Arg Cys Ile Ser Pro Glu Gly Leu Ser225 230 235 240Pro Glu Ala Gln Ile Ser Ile Arg Asp Ile Met Arg Val Val Glu Tyr

245 250 255Ile Ser Ala Asn Asp Val Glu Val Val Phe Leu Glu Asp Thr Leu Asn

260 265 270Gln Asp Ala Leu Arg Lys Ile Val Ser Cys Ser Lys Ser Gly Gln Lys

275 280 285Ile Arg Leu Ala Lys Ser Pro Leu Tyr Ser Asp Asn Val Cys Asp Asn

290 295 300Tyr Phe Ser Thr Phe Gln His Asn Val Arg Thr Ile Thr Glu Glu Leu305 310 315 320Gly Gly Thr Val Leu Glu

325<210>586<211>102<212>PRT<213>沙眼衣原体D血清变型<400>586Met Gln Asn Lys Arg Lys Val Arg Asp Asp Phe Ile Lys Ile Val Lys1 5 10 15Asp Val Lys Lys Asp Phe Pro Glu Leu Asp Leu Lys Ile Arg Val Asn

20 25 30Lys Glu Lys Val Thr Phe Leu Asn Ser Pro Leu Glu Leu Tyr His Lys

35 40 45Ser Val Ser Leu Ile Leu Gly Leu Leu Gln Gln Ile Glu Asn Ser Leu

50 55 60Gly Leu Phe Pro Asp Ser Pro Val Leu Glu Lys Leu Glu Asp Asn Ser65 70 75 80Leu Lys Leu Lys Lys Ala Leu Ile Met Leu Ile Leu Ser Arg Lys Asp

85 90 95Met Phe Ser Lys Ala Glu

100<210>587<211>243<212>PRT<213>沙眼衣原体D血清变型<400>587Val Gly Cys Asn Leu Ala Gln Phe Leu Gly Lys Lys Val Leu Leu Ala1 5 10 15Asp Leu Asp Pro Gln Ser Asn Leu Ser Ser Gly Leu Gly Ala Ser Val

20 25 30Arg Asn Asn Gln Lys Gly Leu His Asp Ile Val Tyr Lys Ser Asn Asp

35 40 45Leu Lys Ser Ile Ile Cys Glu Thr Lys Lys Asp Ser Val Asp Leu Ile

50 55 60Pro Ala Ser Phe Leu Ser Glu Gln Phe Arg Glu Leu Asp Ile His Arg65 70 75 80Gly Pro Ser Asn Asn Leu Lys Leu Phe Leu Asn Glu Tyr Cys Ala Pro

85 90 95Phe Tyr Asp Ile Cys Ile Ile Asp Thr Pro Pro Ser Leu Gly Gly Leu

100 105 110Thr Lys Glu Ala Phe Val Ala Gly Asp Lys Leu Ile Ala Cys Leu Thr

115 120 125Pro Glu Pro Phe Ser Ile Leu Gly Leu Gln Lys Ile Arg Glu Phe Leu

130 135 140Ser Ser Val Gly Lys Pro Glu Glu Glu His Ile Leu Gly Ile Ala Leu145 150 155 160Ser Phe Trp Asp Asp Arg Asn Ser Thr Asn Gln Met Tyr Ile Asp Ile

165 170 175Ile Glu Ser Ile Tyr Lys Asn Lys Leu Phe Ser Thr Lys Ile Arg Arg

180 185 190Asp Ile Ser Leu Ser Arg Ser Leu Leu Lys Glu Asp Ser Val Ala Asn

195 200 205Val Tyr Pro Asn Ser Arg Ala Ala Glu Asp Ile Leu Lys Leu Thr His

210 215 220Glu Ile Ala Asn Ile Leu His Ile Glu Tyr Glu Arg Asp Tyr Ser Gln225 230 235 240Arg Thr Thr<210>588<211>527<212>PRT<213>沙眼衣原体D血清变型<400>588Met Pro Ser Leu Ser Gln Ser Arg Arg Ile Ile Gln Gln Ser Ser Ile1 5 10 15Arg Lys Ile Trp Asn Gln Ile Asp Thr Ser Pro Lys His Gly Val Cys

20 25 30Val Pro Leu Phe Ser Leu Tyr Thr Gln Glu Ser Cys Gly Ile Gly Glu

35 40 45Phe Leu Asp Leu Ile Pro Met Ile Asp Trp Cys Ile Ser Cys Gly Phe

50 55 60Gln Ile Leu Gln Ile Leu Pro Ile Asn Asp Thr Gly Ser Cys Ser Ser65 70 75 80Pro Tyr Asn Ser Ile Ser Ser Ile Ala Leu Asn Pro Leu His Leu Ser

85 90 95Ile Ser Ala Leu Pro Tyr Lys Glu Glu Val Pro Ala Ala Glu Thr Arg

100 105 110Ile Arg Glu Met Gln Gln Leu Ser Gln Leu Pro Gln Val His Tyr Glu

115 120 125Lys Val Arg Ser Met Lys Arg Asp Phe Phe Gln Glu Tyr Tyr Arg Val

130 135 140Cys Lys Gln Lys Lys Leu Thr Asp His Pro Asp Phe Tyr Ala Phe Cys145 150 155 160Glu Gln Glu Lys Tyr Trp Leu His Pro Tyr Ala Leu Phe Arg Ser Ile

165 170 175Arg Glu His Leu Asp Asn Leu Pro Ile Asn His Trp Pro Thr Thr Tyr

180 185 190Thr Asp Leu Ser Gln Ile Thr Glu His Glu Arg Thr Phe Ala Glu Asp

195 200 205Ile Gln Phe His Ser Tyr Leu Gln Tyr Leu Cys Phe Gln Gln Met Thr

210 215 220Gln Val Arg Glu His Ala Asn Cys Lys Ser Cys Leu Ile Lys Gly Asp225 230 235 240Ile Pro Ile Leu Ile Ser Lys Asp Ser Cys Asp Val Trp Phe Tyr Arg

245 250 255His Tyr Phe Ser Ser Ser Glu Ser Val Gly Ala Pro Pro Asp Leu Tyr

260 265 270Asn Ala Glu Gly Gln Asn Trp His Leu Pro Ile Cys Asn Met Lys Thr

275 280 285Leu Gln Gln Asp Asn Tyr Leu Trp Trp Lys Glu Arg Leu Arg Tyr Ala

290 295 300Glu Asn Phe Tyr Ser Leu Tyr Arg Leu Asp His Val Val Gly Leu Phe305 310 315 320Arg Phe Trp Val Trp Asp Glu Ser Gly Cys Gly Arg Phe Glu Pro His

325 330 335Asp Pro Lys Asn Tyr Leu Ala Gln Gly Gln Asp Ile Leu Ser His Leu

340 345 350Leu Thr Ser Ser Ser Met Leu Pro Ile Gly Glu Asp Leu Gly Thr Ile

355 360 365Pro Ser Asp Val Lys Arg Met Leu Glu Ser Phe Ala Val Cys Gly Thr

370 375 380Arg Ile Pro Arg Trp Glu Arg Asn Trp Glu Gly Asn Gly Ala Tyr Thr385 390 395 400Pro Phe Asp Gln Tyr Asp Pro Leu Ser Val Thr Ser Leu Ser Thr His

405 410 415Asp Ser Ser Thr Leu Ala Ser Trp Trp Lys Glu Ser Pro Gln Glu Ser

420 425 430Lys Leu Phe Ala Gln Phe Leu Gly Leu Pro Tyr Ser Ser Thr Leu Ser

435 440 445Leu His Asn His Thr Glu Ile Leu Lys Leu Ser His Lys Thr Ser Ser

450 455 460Ile Phe Arg Ile Asn Leu Ile Asn Asp Tyr Leu Ala Leu Phe Pro Asp465 470 475 480Leu Ile Ser Lys Thr Pro Arg Tyr Glu Arg Ile Asn Leu Pro Gly Thr

485 490 495Ile Ser Lys Asn Asn Trp Val Tyr Arg Val Lys Pro Ser Ile Glu Asp

500 505 510Leu Ser Ser His Ser Lys Leu Asn Ser Leu Leu Glu Ala Leu Phe

515 520 525<210>589<211>146<212>PRT<213>沙眼衣原体D血清变型<400>589Met Gln Asn Gln Phe Glu Gln Leu Leu Thr Glu Leu Gly Thr Gln Ile1 5 10 15Asn Ser Pro Leu Thr Pro Asp Ser Asn Asn Ala Cys Ile Val Arg Phe

20 25 30Gly Tyr Asn Asn Val Ala Val Gln Ile Glu Glu Asp Gly Asn Ser Gly

35 40 45Phe Leu Val Ala Gly Val Met Leu Gly Lys Leu Pro Glu Asn Thr Phe

50 55 60Arg Gln Lys Ile Phe Lys Ala Ala Leu Ser Ile Asn Gly Ser Pro Gln65 70 75 80Ser Asn Ile Lys Gly Thr Leu Gly Tyr Gly Glu Ile Ser Asn Gln Leu

85 90 95Tyr Leu Cys Asp Arg Leu Asn Met Thr Tyr Leu Asn Gly Glu Lys Leu

100 105 110Ala Arg Tyr Leu Val Leu Phe Ser Gln His Ala Asn Ile Trp Met Gln

115 120 125Ser Ile Ser Lys Gly Ala Leu Pro Asp Leu His Ala Leu Gly Met Tyr

130 135 140His Leu145<210>590<211>650<212>PRT<213>沙眼衣原体D血清变型<400>590Met Thr Ile Pro Ile His Glu Asn Lys Tyr Ser Met Ile Ser Phe Thr1 5 10 15Arg Thr Ile Gly Phe Arg Leu Trp Leu Ile Cys Val Ala Ala Ile Met

20 25 30Phe Pro Leu Gly Ile Asn Ile Leu Gln Leu Asn Leu Gln Gln Tyr Lys

35 40 45Lys Thr Leu Ser Ser Ile Thr Ser Asp Leu Arg Glu Asn Ala Leu Phe

50 55 60Lys Ala His Thr Leu Gln Gln Thr Ile Pro Leu Asn Ile Asp Ile Leu65 70 75 80Ala Leu Phe Ser Glu Ile Phe Asp Leu Asp Arg Gly Val Pro Ala Glu

85 90 95Pro Asp Leu Ala Leu Ser Lys Glu Met Glu Lys Ile Phe His Ser Thr

100 105 110Tyr Lys Glu Ile Ser Leu Val Lys Lys Glu Ala Asp Gly Asn Phe Arg

115 120 125Val Val Ala Ser Ser Arg Ile Glu Gln Leu Gly Lys Asn Tyr Asn Gln

130 135 140Glu Ile Phe Leu Ser Asp Ser Gln Pro Phe Leu Ala Thr Leu Arg His145 150 155 160Ser Gly Ser Asp Ser Gln Val Leu Ala Val Leu Gln Thr Asn Ile Phe

165 170 175Asp Ile Ser Ser Gln Glu Val Leu Gly Val Leu Tyr Thr Leu Ser Asp

180 185 190Thr Asn Tyr Leu Leu Asn Gly Leu Leu Ala Ala Lys Asp Pro Leu Ser

195 200 205Val Lys Thr Ala Ile Leu Ser Lys Asn Gly Ile Ile Leu Gln Ala Thr

210 215 220Asp Ser Ser Leu Asp Leu Val Ser Ile His Lys Thr Val Ser Lys Glu225 230 235 240Gln Phe Cys Asp Val Phe Leu Arg Asp Asp Ile Cys Pro Pro His Leu

245 250 255Leu Leu Arg Pro Pro Leu Asn Leu Asp Pro Leu Pro Tyr Gly Glu Asn

260 265 270Phe Val Ser Phe Cys Ile Gly Asn Thr Glu Met Trp Gly Tyr Ile His

275 280 285Ser Leu Pro Glu Met Asp Phe Arg Ile Leu Thr Tyr Glu Glu Lys Ser

290 295 300Ile Ile Phe Ala Ser Leu Trp Arg Arg Thr Leu Leu Tyr Phe Ala Tyr305 310 315 320Phe Cys Cys Val Leu Leu Gly Ser Ile Thr Ala Phe Leu Val Ala Lys

325 330 335Arg Leu Ser Lys Pro Ile Arg Lys Leu Ala Thr Ala Met Met Glu Thr

340 345 350Arg Arg Asn Gln His His Pro Tyr Glu Pro Asp Ser Leu Gly Phe Glu

355 360 365Ile Asn His Leu Gly Glu Ile Phe Asn Ser Met Val Gln Ser Leu Leu

370 375 380Gln Gln Gln Ser Leu Ala Glu Lys Asn Phe Glu Ile Lys Gln His Ala385 390 395 400Gln Asn Ala Leu Arg Leu Gly Glu Glu Ala Gln Gln Cys Leu Leu Pro

405 410 415Asn Gln Leu Pro Asp Ser Pro Thr Thr Glu Ile Ala Lys Ala Tyr Ile

420 425 430Pro Ala Ile Thr Val Gly Gly Asp Phe Phe Asp Ile Phe Val Ile Gly

435 440 445Glu Gly Pro Gln Ala Lys Leu Phe Leu Ile Val Ala Asp Ala Ser Gly

450 455 460Lys Gly Val Asn Ala Cys Ala Tyr Ser Leu Phe Leu Lys Asn Met Leu465 470 475 480His Thr Phe Leu Ser Glu Leu Ser Ser Ile Gln Glu Ala Val Gln Gln

485 490 495Thr Ala Ala Leu Phe Tyr Gln Gln Thr Ala Glu Ser Gly Met Phe Val

500 505 510Thr Leu Cys Ile Tyr Cys Tyr His Tyr Ala Thr Arg Glu Leu Glu Tyr

515 520 525Tyr Ser Cys Gly His Asn Pro Ala Cys Leu Arg Ala Pro Asn Gly Asp

530 535 540Ile Ser Phe Leu Ser His Pro Gly Met Ala Leu Gly Phe Leu Pro Glu545 550 555 560Val Pro Pro His Pro Ala Tyr Thr Leu Val Leu Glu Glu Glu Ser Leu

565 570 575Leu Val Leu Tyr Thr Asp Gly Val Thr Glu Ala Ser Asn Lys His Gly

580 585 590Glu Met Phe Gly Glu Glu Arg Leu Lys Ala Leu Val Ala Ser Leu Thr

595 600 605Lys Gln Ser Ala Glu Glu Ala Ile Gln Ser Ile Met Phe Ser Ile Lys

610 615 620Ser Phe Val Lys Asp Cys Pro Gln His Asp Asp Ile Thr Leu Leu Val625 630 635 640Leu Lys Ile Pro Lys Glu Pro Ser Ala Tyr

645 650<210>591<211>313<212>PRT<213>沙眼衣原体D血清变型<400>591Met Leu Ser Tyr Ile Lys Arg Arg Leu Leu Phe Asn Leu Leu Ser Leu1 5 10 15Trp Val Val Val Thr Leu Thr Phe Phe Ile Ile Lys Thr Ile Pro Gly

20 25 30Asp Pro Phe Asn Asp Glu Asn Gly Asn Ile Leu Ser Ser Glu Thr Leu

35 40 45Ala Leu Leu Lys Asn Arg Tyr Gly Leu Asp Lys Pro Leu Phe Thr Gln

50 55 60Tyr Leu Ile Tyr Leu Lys Cys Leu Leu Thr Leu Asp Phe Gly Glu Ser65 70 75 80Leu Ile Tyr Lys Asp Arg Thr Val Ile Ser Ile Ile Ala Ala Ala Leu

85 90 95Pro Ser Ser Ala Ile Leu Gly Leu Glu Ser Leu Cys Leu Ser Leu Phe

100 105 1l0Gly Gly Ile Thr Leu Gly Ile Leu Ala Ala Phe Tyr Lys Lys Ser Cys

115 120 125Gly Arg Thr Ile Phe Phe Ser Ser Val Ile Gln Ile Ser Val Pro Ala

130 135 140Phe Val Ile Gly Ala Phe Leu Gln Tyr Val Phe Ala Ile Lys Tyr Ser145 150 155 160Cys Leu Pro Ile Ala Cys Trp Gly Asn Phe Ser His Thr Leu Leu Pro

165 170 175Ser Ile Ala Leu Ala Ile Thr Pro Met Ala Phe Ile Thr Gln Leu Thr

180 185 190Cys Ala Ser Val Ser Ala Asn Leu Lys Lys Asp Tyr Val Leu Leu Ala

195 200 205Tyr Ala Lys Gly Leu Ser Pro Phe Lys Val Leu Ile Lys His Ile Leu

210 215 220Pro Tyr Ala Leu Phe Pro Val Ile Ser Tyr Ser Ala Phe Leu Ile Thr225 230 235 240Thr Leu Met Thr Gly Thr Phe Ser Ile Glu Asn Leu Phe Cys Ile Pro

245 250 255Gly Leu Gly Lys Trp Phe Ile Cys Ser Ile Lys Gln Arg Asp Tyr Pro

260 265 270Ile Thr Leu Gly Leu Ser Val Phe Tyr Gly Ala Phe Phe Met Leu Thr

275 280 285Ser Leu Cys Cys Asp Leu Leu Gln Ala Trp Ile Asp Pro Gln Ile Arg

290 295 300Tyr Ser Tyr Gly Lys Glu Arg Ser Lys305 310<210>592<211>1237<212>PRT<213>沙眼衣原体D血清变型<400>592Met Thr Trp Ile Pro Leu His Cys His Ser Gln Tyr Ser Ile Leu Asp1 5 10 15Ala Thr Cys Ser Ile Lys Lys Phe Val Ala Lys Ala Val Glu Tyr Gln

20 25 30Ile Pro Ala Leu Ala Leu Thr Asp His Gly Asn Leu Phe Gly Ala Val

35 40 45Glu Phe Tyr Lys Thr Cys Lys Gln Asn Ala Ile Lys Pro Ile Ile Gly

50 55 60Cys Glu Leu Tyr Val Ala Pro Ser Ser Arg Phe Asp Lys Lys Lys Glu65 70 75 80Arg Lys Ser Arg Val Ala Asn His Leu Ile Leu Leu Cys Lys Asp Glu

85 90 95Glu Gly Tyr Arg Asn Leu Cys Leu Leu Ser Ser Leu Ala Tyr Thr Glu

100 105 110Gly Phe Tyr Tyr Val Pro Arg Ile Asp Arg Asp Leu Leu Ser Gln His

115 120 125Ser Lys Gly Leu Ile Cys Leu Ser Ala Cys Leu Ser Gly Ser Val Ala

130 135 140Gln Ala Ala Leu Glu Ser Glu Glu Asp Leu Glu Lys Asp Leu Leu Trp145 150 155 160Tyr Gln Asp Leu Phe Gln Glu Asp Phe Phe Ser Glu Val Gln Leu His

165 170 175Lys Ser Ser Glu Glu Lys Val Ala Lau Phe Glu Glu Thr Trp Leu Lys

180 185 190Gln Asn Tyr Tyr Gln Phe Ile Glu Lys Gln Leu Lys Val Asn Glu Ala

195 200 205Val Leu Ala Thr Ser Lys Arg Leu Gly Ile Pro Ser Val Ala Thr Asn

210 215 220Asp Ile His Tyr Leu Asn Pro Asp Asp Trp Leu Ala His Glu Ile Leu225 230 235 240Leu Asn Val Gln Ser Arg Glu Pro Ile Arg Thr Ala Lys Gln Asn Thr

245 250 255Tyr Ile Pro Asn Pro Lys Arg Lys Thr Tyr Pro Ser Arg Glu Phe Tyr

260 265 270Phe Lys Ser Pro Gln Glu Ile Ala Glu Leu Phe Ala Ala His Pro Glu

275 280 285Thr Ile Thr Asn Thr Cys Ile Val Ala Glu Arg Cys His Leu Glu Leu

290 295 300Asp Phe Glu Thr Lys His Tyr Pro Ile Tyr Val Pro Glu Ala Leu Gln305 310 315 320Lys Lys Gly Ser Tyr Thr Glu Glu Glu Arg Tyr Lys Ala Ser Ser Ala

325 330 335Phe Leu Glu Glu Leu Cys Glu Gln Gly Leu Thr Ser Lys Tyr Thr Pro

340 345 350Glu Leu Leu Gly His Ile Ala Lys Lys Phe Pro Gly Glu Asp Pro Leu

355 360 365Thr Leu Val Lys Glu Arg Leu Lys Leu Glu Ser Ser Ile Ile Ile Ser

370 375 380Lys Gly Met Cys Asp Tyr Leu Leu Ile Val Trp Asp Ile Ile Asn Trp385 390 395 400Ala Lys Asp His Gly Ile Pro Val Gly Pro Gly Arg Gly Ser Gly Ala

405 410 415Gly Ser Val Met Leu Phe Leu Leu Gly Ile Thr Glu Ile Glu Pro Ile

420 425 430Arg Phe Asp Leu Phe Phe Glu Arg Phe Ile Asn Pro Glu Arg Ile Ser

435 440 445Tyr Pro Asp Ile Asp Ile Asp Ile Cys Met Ile Gly Arg Glu Arg Val

450 455 460Ile Asn Tyr Ala Ile Glu Arg His Gly Lys Asp Asn Val Ala Gln Ile465 470 475 480Ile Thr Phe Gly Thr Met Lys Ala Lys Met Ala Ile Lys Asp Val Gly

485 490 495Arg Thr Leu Asp Thr Pro Leu Ala Lys Val Asn Phe Ile Ala Lys His

500 505 510Ile Pro Asp Leu Asn Ala Thr Ile Thr Ser Ala Leu Glu Ala Asp Pro

515 520 525Glu Leu Arg Gln Leu Tyr Val Asp Asp Ala Glu Ala Ala Glu Val Ile

530 535 540Asp Met Ala Lys Lys Leu Glu Gly Ser Ile Arg Asn Thr Gly Val His545 550 555 560Ala Ala Gly Val Ile Ile Cys Gly Asp Pro Leu Thr Asn His Ile Pro

565 570 575Ile Cys Val Pro Lys Asp Ser Ser Met Ile Ser Thr Gln Tyr Ser Met

580 585 590Lys Pro Val Glu Ser Val Gly Met Leu Lys Val Asp Phe Leu Gly Leu

595 600 605Lys Thr Leu Thr Gly Ile His Ile Ala Thr Gln Ala Ile Tyr Lys Lys

610 615 620Thr Gly Ile Leu Leu Arg Ala Ala Thr Ile Pro Leu Asp Asp Gln Asn625 630 635 640Thr Phe Ser Leu Leu His Gln Gly Lys Thr Met Gly Ile Phe Gln Met

645 650 655Glu Ser Arg Gly Met Gln Asp Leu Ala Lys Asn Leu Arg Pro Asp Ala

660 665 670Phe Glu Glu Ile Ile Ala Ile Gly Ala Leu Tyr Arg Pro Gly Pro Met

675 680 685Asp Met Ile Pro Ser Phe Ile Asn Arg Lys His Gly Lys Glu Asn Ile

690 695 700Glu Tyr Asp His Pro Leu Met Glu Pro Ile Leu Lys Glu Thr Phe Gly705 710 715 720Ile Met Val Tyr Gln Glu Gln Val Met Gln Ile Ala Gly Ser Leu Ala

725 730 735Lys Tyr Ser Leu Gly Glu Gly Asp Val Leu Arg Arg Ala Met Gly Lys

740 745 750Lys Asp His Glu Gln Met Val Lys Glu Arg Glu Lys Phe Cys Ser Arg

755 760 765Ala Ala Ala Asn Gly Ile Asp Pro Ser Ile Ala Thr Thr Ile Phe Asp

770 775 780Lys Met Glu Lys Phe Ala Ser Tyr Gly Phe Asn Lys Ser His Ala Ala785 790 795 800Ala Tyr Gly Leu Ile Thr Tyr Thr Thr Ala Tyr Leu Lys Ala Asn Tyr

805 810 815Pro Lys Glu Trp Leu Ala Ala Leu Leu Thr Cys Asp Tyr Asp Asp Ile

820 825 830Glu Lys Val Gly Lys Leu Ile Gln Glu Ala His Ser Met Asn Ile Leu

835 840 845Val Leu Pro Pro Asp Ile Asn Glu Ser Gly Gln Asp Phe Glu Ala Thr

850 855 860Gln Lys Gly Ile Arg Phe Ser Leu Gly Ala Val Lys Gly Val Gly Met865 870 875 880Ser Ile Val Asp Ser Ile Val Glu Glu Arg Glu Lys Asn Gly Pro Tyr

885 890 895Lys Ser Leu Gln Asp Phe Val Gln Arg Ala Asp Phe Lys Lys Val Thr

900 905 910Lys Lys Gln Leu Glu Asn Leu Val Asp Ala Gly Thr Phe Asp Cys Phe

915 920 925Glu Pro Asn Lys Asp Leu Ala Leu Ala Ile Leu Asn Asp Leu Tyr Asp

930 935 940Thr Phe Ser Arg Glu Lys Lys Glu Ala Ala Thr Gly Val Leu Thr Phe945 950 955 960Phe Ser Leu Asp Ser Met Ala Arg Asp Pro Val Lys Ile Thr Val Ser

965 970 975Pro Glu Asn Val Ile Gln Arg Ser Pro Lys Glu Leu Leu Lys Arg Glu

980 985 990Lys Glu Leu Leu Gly Val Tyr Leu Thr Ala His Pro Met Asp Ala Val

995 1000 1005Glu His Met Leu Pro Phe Leu Ser Val Val Pro Ala Arg Asp Phe Glu

1010 1015 1020Gly Leu Pro His Gly Thr Ile Ile Arg Thr Val Phe Leu Ile Asp Lys1025 1030 1035 1040Val Thr Thr Lys Ile Ser Ser Ala Glu Gln Lys Lys Phe Ala Leu Leu

1045 1050 1055Gln Val Ser Asp Glu Val Asp Ser Tyr Glu Leu Pro Ile Trp Ala Asp

1060 1065 1070Met Tyr Ala Glu Tyr Arg Asp Leu Leu Glu Glu Asp Arg Leu Ile Tyr

1075 1080 1085Ala Ile Leu Ala Ile Asp Arg Arg Ser Asp Ser Leu Arg Leu Ser Cys

1090 1095 1100Arg Trp Met Arg Asp Leu Ser Thr Val Asn Asp Ser Val Ile Ala Glu1105 1110 1115 1120Cys Asp Glu Val Tyr Asp Arg Leu Lys Ser Gln Lys Val Tyr Ser Ser

1125 1130 1135Thr Lys Lys Ser Thr Gly Ala Gln Ser Ser Ala Met Ile Lys Lys Val

1140 1145 1150Glu Thr Arg Glu Ile Ser Pro Val Thr Ile Ser Leu Asp Leu Asn Lys

1155 1160 1165Leu Arg His Ser His Leu Phe Ile Leu Lys Gly Leu Ile Arg Lys Tyr

1170 1175 1180Ser Gly Ser Gln Ala Leu Ser Leu Val Phe Thr Lys Asp Asn Gln Arg1185 1190 1195 1200Phe Ala Ser Ile Ser Pro Asp Ala Asp Phe Phe Val Thr Asp Asp Ile

1205 1210 1215Ser Ser Leu Leu Gln Glu Ile Glu Ala Thr Asn Ile Pro Ala Arg Val

1220 1225 1230Leu Ala Thr Thr Val

1235<210>593<211>563<212>PRT<213>沙眼衣原体D血清变型<400>593Met Val Tyr Phe Arg Ala His Gln Pro Arg His Thr Pro Lys Thr Phe1 5 10 15Pro Leu Glu Val His His Ser Phe Ser Asp Lys His Pro Gln Ile Ala

20 25 30Lys Ala Met Arg Ile Thr Gly Ile Ala Leu Ala Ala Leu Ser Leu Leu

35 40 45Ala Val Val Ala Cys Val Ile Ala Val Ser Ala Gly Gly Ala Ala Ile

50 55 60Pro Leu Ala Val Ile Ser Gly Ile Ala Val Met Ser Gly Leu Leu Ser65 70 75 80Ala Ala Thr Ile Ile Cys Ser Ala Lys Lys Ala Leu Ala Gln Arg Lys

85 90 95Gln Lys Gln Leu Glu Glu Ser Leu Pro Leu Asp Asn Ala Thr Glu His

100 105 110Val Ser Tyr Leu Thr Ser Asp Thr Ser Tyr Phe Asn Gln Trp Glu Ser

115 120 125Leu Gly Ala Leu Asn Lys Gln Leu Ser Gln Ile Asp Leu Thr Ile Gln

130 135 140Ala Pro Glu Lys Lys Leu Leu Lys Glu Val Leu Gly Ser Arg Tyr Asp145 150 155 160Ser Ile Asn His Ser Ile Glu Glu Ile Ser Asp Arg Phe Thr Lys Met

165 170 175Leu Ser Leu Leu Arg Leu Arg Glu His Phe Tyr Arg Gly Glu Glu Arg

180 185 190Tyr Ala Pro Tyr Leu Ser Pro Pro Leu Leu Asn Lys Asn Arg Leu Leu

195 200 205Thr Gln Ile Thr Ser Asn Met Ile Arg Met Leu Pro Lys Ser Gly Gly

210 215 220Val Phe Ser Leu Lys Ala Asn Thr Leu Ser His Ala Ser Arg Thr Leu225 230 235 240Tyr Thr Val Leu Lys Val Ala Leu Ser Leu Gly Val Leu Ala Gly Val

245 250 255Ala Ala Leu Ile Ile Phe Leu Pro Pro Ser Leu Pro Phe Ile Ala Val

260 265 270Ile Gly Val Ser Ser Leu Ala Leu Gly Met Ala Ser Phe Leu Met Ile

275 280 285Arg Gly Ile Lys Tyr Leu Leu Glu His Ser Pro Leu Asn Arg Lys Gln

290 295 300Leu Ala Lys Asp Ile Gln Lys Thr Ile Gly Pro Asp Val Leu Ala Ser305 310 315 320Met Val His Tyr Gln His Gln Leu Leu Ser His Leu His Glu Thr Leu

325 330 335Leu Asp Glu Ala Ile Thr Ala Arg Trp Ser Glu Pro Phe Phe Ile Glu

340 345 350His Ala Asn Leu Lys Ala Lys Ile Glu Asp Leu Thr Lys Gln Tyr Asp

355 360 365Ile Leu Asn Ala Ala Phe Asn Lys Ser Leu Gln Gln Asp Glu Ala Leu

370 375 380Arg Ser Gln Leu Glu Lys Arg Ala Tyr Leu Phe Pro Ile Pro Asn Asn385 390 395 400Asp Glu Asn Ala Lys Thr Lys Glu Ser Gln Leu Leu Asp Ser Glu Asn

405 410 415Asp Ser Asn Ser Glu Phe Gln Glu Ile Ile Asn Lys Gly Leu Glu Ala

420 425 430Ala Asn Lys Arg Arg Ala Asp Ala Lys Ser Lys Phe Tyr Thr Glu Asp

435 440 445Glu Thr Ser Asp Lys Ile Phe Ser Ile Trp Lys Pro Thr Lys Asn Leu

450 455 460Ala Leu Glu Asp Leu Trp Arg Val His Glu Ala Cys Asn Glu Glu Gln465 470 475 480Gln Ala Leu Leu Leu Glu Asp Tyr Met Ser Tyr Lys Thr Ser Glu Cys

485 490 495Gln Ala Ala Leu Gln Lys Val Ser Gln Glu Leu Lys Ala Ala Gln Lys

500 505 5l0Ser Phe Ala Val Leu Glu Lys His Ala Leu Asp Arg Ser Tyr Glu Ser

515 520 525Ser Val Ala Thr Met Asp Leu Ala Arg Ala Asn Gln Glu Thr His Arg

530 535 540Leu Leu Asn Ile Leu Ser Glu Leu Gln Gln Leu Ala Gln Tyr Leu Leu545 550 555 560Asp Asn His<210>594<211>1751<212>PRT<213>沙眼衣原体D血清变型<400>594Met Lys Trp Leu Ser Ala Thr Ala Val Phe Ala Ala Val Leu Pro Ser1 5 10 15Val Ser Gly Phe Cys Phe Pro Glu Pro Lys Glu Leu Asn Phe Ser Arg

20 25 30Val Gly Thr Ser Ser Ser Thr Thr Phe Thr Glu Thr Val Gly Glu Ala

35 40 45Gly Ala Glu Tyr Ile Val Ser Gly Asn Ala Ser Phe Thr Lys Phe Thr

85 90 95Thr Thr Thr Pro Asp Pro Lys Gly Gly Gly Ala Phe Tyr Asn Ala His

100 105 110Ser Gly Val Leu Ser Phe Met Thr Arg Ser Gly Thr Glu Gly Ser Leu

115 120 125Thr Leu Ser Glu Ile Lys Ile Thr Gly Glu Gly Gly Ala Ile Phe Ser

165 170 175Ser Leu Ser Gly Ile Thr Lys Ala Thr Phe Ser Ser Asn Ser Ala Glu

180 185 190Val Pro Ala Pro Val Lys Lys Pro Thr Glu Pro Lys Ala Gln Thr Ala

195 200 205Ser Glu Thr Ser Gly Ser Ser Ser Ser Ser Gly Asn Asp Ser Val Ser

245 250 255Thr Ser Thr Pro Ser His Lys Pro Gly Ser Gly Gly Ala Ile Tyr Ala

260 265 270Lys Gly Asp Leu Thr Ile Ala Asp Ser Gln Glu Val Leu Phe Ser Ile

275 280 285Asn Lys Ala Thr Lys Asp Gly Gly Ala Ile Phe Ala Glu Lys Asp Val

325 330 335Ser Lys Gln Ser Leu Phe Asn Ser Asn Tyr Ser Lys Gln Gly Gly Gly

340 345 350Ala Leu Tyr Val Glu Gly Asp Ile Asn Phe Gln Asp Leu Glu Glu Ile

355 360 365Arg Ile Lys Tyr Asn Lys Ala Gly Thr Phe Glu Thr Lys Lys Ile Thr

405 410 415Asp Ser Ser Ser Gly Ser Asp Ser Asp Thr Ser Glu Thr Val Pro Ala

420 425 430Thr Ala Lys Gly Gly Gly Leu Tyr Thr Asp Lys Asn Leu Ser Ile Thr

435 440 445Asn Ile Thr Gly Ile Ile Glu Ile Ala Asn Asn Lys Ala Thr Asp Val

485 490 495Tyr Gly Glu Asp Asn Ile Thr Leu Ser Asn Leu Thr Gly Lys Thr Leu

500 505 510Phe Gln Glu Asn Thr Ala Lys Glu Glu Gly Gly Gly Leu Phe Ile Lys

515 520 525Gly Thr Asp Lys Ala Leu Thr Met Thr Gly Leu Asp Ser Phe Cys Leu

565 570 575Thr Pro Val His Gly Glu Thr Val Ile Thr Gly Asn Lys Ser Thr Gly

580 585 590Gly Asn Gly Gly Gly Val Cys Thr Lys Arg Leu Ala Leu Ser Asn Leu

595 600 605Gln Ser Ile Ser Ile Ser Gly Asn Ser Ala Ala Glu Asn Gly Gly Gly

645 650 655Val Ser Thr Ala Leu Ser Thr Pro Ser Ser Ser Thr Val Ser Ser Leu

660 665 670Thr Leu Leu Ala Ala Ser Ser Gln Ala Ser Pro Ala Thr Ser Asn Lys

675 680 685Glu Thr Gln Asp Pro Asn Ala Asp Thr Asp Leu Leu Ile Asp Tyr Val

725 730 735Glu Asn Ser Ala Thr Glu Ile Gly Gly Gly Ile Cys Cys Lys Glu Ser

740 745 750Leu Glu Leu Asp Ala Leu Val Ser Leu Ser Val Thr Glu Asn Leu Val

755 760 765Gly Lys Glu Gly Gly Gly Leu His AIa Lys Thr Val Asn Ile Ser Asn

805 810 815Leu Gln Ala Ala Ala Ala Ala Val Pro Ser Ser Pro Ala Thr Pro Thr

820 825 830Tyr Ser Gly Val Val Gly Gly Ala Ile Tyr Gly Glu Lys Val Thr Phe

835 840 845Ser Gln Cys Ser Gly Thr Cys Gln Phe Ser Gly Asn Gln Ala Ile Asp

885 890 895Ile Phe Ser Gly Asn Ser Val Ser Thr Gly Lys Ser Gln Thr Thr Gly

900 905 910Gln Ile Ala Gly Gly Ala Ile Tyr Ser Pro Thr Val Thr Leu Asn Cys

915 920 925Pro Ala Thr Phe Ser Asn Asn Thr Ala Ser Met Ala Thr Pro Lys Thr

965 970 975Ser Gly Asn Thr Ala Asp Leu Gly Ala Ala Ile Gly Thr Leu Ala Asn

980 985 990Ala Asn Thr Pro Ser Ala Thr Ser Gly Ser Gln Asn Ser Ile Thr Glu

995 1000 1005Lys Ile Thr Leu Glu Asn Gly Ser Phe Ile Phe Glu Arg Asn Gln Ala

1045 1050 1055Tyr Phe Thr Lys Asp Ala Thr Ile Glu Ser Leu Gly Ser Val Leu Phe

1060 1065 1070Thr Gly Asn Asn Val Thr Ala Thr Gln Ala Ser Ser Ala Thr Ser Gly

1075 1080 1085Gln Asn Thr Asn Thr Ala Asn Tyr Gly Ala Ala Ile Phe Gly Asp Pro

1125 1130 1135Gly Asp Thr Pro Ala Ser Lys Phe Cys Ser Ile Ala Gly Tyr Val Lys

1140 1145 1150Leu Ser Leu Gln Ala Ala Lys Gly Lys Thr Ile Ser Phe Phe Asp Cys

1155 1160 1165Val His Thr Ser Thr Lys Lys Ile Gly Ser Thr Gln Asn Val Tyr Glu

1205 1210 1215Asn Ala Ile Leu His Asn Gly Thr Leu Val Leu Lys Glu Lys Thr Glu

1220 1225 1230Leu His Val Val Ser Phe Glu Gln Lys Glu Gly Ser Lys Leu Ile Met

1235 1240 1245Lys Pro Gly Ala Val Leu Ser Asn Gln Asn Ile Ala Asn Gly Ala Leu

1285 1290 1295Ser Ser Ala Ser Gly Gly Ser Gly Val Ser Ser Ser Ile Pro Thr Asn

1300 1305 1310Pro Lys Arg Ile Ser Ala Ala Ala Pro Ser Gly Ser Ala Ala Thr Thr

1315 1320 1325Pro Thr Met Ser Glu Asn Lys Val Phe Leu Thr Gly Asp Leu Thr Leu

1365 1370 1375Val Tyr Asp Leu Thr Leu Ser Gly Asp Leu Phe Pro Gln Lys Gly Tyr

1380 1385 1390Met Gly Thr Trp Thr Leu Asp Ser Asn Pro Gln Thr Gly Lys Leu Gln

1395 1400 1405Ala Arg Trp Thr Phe Asp Thr Tyr Arg Arg Trp Val Tyr Ile Pro Arg

1410 1415 1420Asp Asn His Phe Tyr Ala Asn Ser Ile Leu Gly Ser Gln Asn Ser Met1425 1430 1435 1440Ile Val Val Lys Gln Gly Leu Ile Asn Asn Met Leu Asn Asn Ala Arg

1445 1450 1455Phe Asp Asp Ile Ala Tyr Asn Asn Phe Trp Val Ser Gly Val Gly Thr

1460 l465 1470Phe Leu Ala Gln Gln Gly Thr Pro Leu Ser Glu Glu Phe Ser Tyr Tyr

1475 1480 1485Ser Arg Gly Thr Ser Val Ala Ile Asp Ala Lys Pro Arg Gln Asp Phe

1525 1530 1535Ala Ser Val Tyr Gly Gly Lys Phe Leu Tyr Phe Leu Leu Asn Lys Gln

1540 1545 1550His Gly Trp Ala Leu Pro Phe Leu Ile Gln Gly Val Val Ser Tyr Gly

1555 1560 1565His Ile Lys His Asp Thr Thr Thr Leu Tyr Pro Ser Ile His Glu Arg

1605 1610 1615Val Tyr Gly Glu Leu Glu Tyr Ser Ser Ile Arg Gln Lys Gln Phe Thr

1620 1625 1630Glu Ile Asp Tyr Asp Pro Arg His Phe Asp Asp Cys Ala Tyr Arg Asn

1635 1640 1645Leu Ser Leu Pro Val Gly Cys Ala Val Glu Gly Ala Ile Met Asn Cys

1685 1690 1695Ala Gly Gln Val Ile Cys Gly Val Pro Thr Arg Thr Ser Ala Arg Ala

1700 1705 1710Glu Tyr Ser Thr Gln Leu Tyr Leu Gly Pro Phe Trp Thr Leu Tyr Gly

1715 1720 1725Asn Tyr Thr Ile Asp Val Gly Met Tyr Thr Leu Ser Gln Met Thr Ser

1730 1735 1740Cys Gly Ala Arg Met Ile Phe1745 1750<210>595<211>900<212>DNA<213>肺炎衣原体<400>595atgctaaaga ttgatctaac aggaaaggta gcatttgttg cgggcattgg tgatgaccaa 60ggatatggct ggggtattgc taaacttctt gcagaagcag gagctacgat tattgtagga 120acatgggtac cgatttacaa aattttctct cagtcttggg aattaggaaa attcaatgaa 180tctagaaaat tatcgaatgg cactctctta gagattgcta agatctatcc catggacgca 240agttttgata gccctgaaga tgttcctgaa gatattgctg aaaataaacg ttacaagggc 300attacgggat tcacgatatc agaagtcgca gaacaggtaa aaaaagattt tggtcatatt 360gacattcttg tccactcgct ggcaaatagt cctgaaattt ctaagtctct attagaaaca 420tcaagaaaag gttacttagc ggctctcagt gcctctagtt attcttttgt tagccttctc 480tctcactttg gaagtatcat gaaccgtggt ggatcgacaa tatcgctcac ctatttggct 540tctatgcgcg ctgttcctgg atacggaggg ggcatgagtt cggcaaaagc agctttggaa 600agtgacacca aaactcttgc ttgggaagcg ggacgccgtt ggggcatacg tgtcaatacc 660atctctgcag gacctttagc aagccgagct ggaaaagcaa ttggttttat tgaaagaatg 720gtagactatt accaagagtg ggcgcctatt cccgaggcta tgaatgccga gcaggtgggt 780gccgttgcag ctttcttagc atcacctcta gcttcagcaa ttactggtga gaccttatac 840gtagatcacg gagccaatgt gatgggaatt ggtcctgaga tgttccctaa agactcataa 900<210>596<211>1743<212>DNA<213>肺炎衣原体<400>596atgccaaaac aagctgaata tacttgggga tctaaaaaaa ttctggacaa tatagaatgc 60ctcacagaag acgttgccga atttaaagat ttgctttata cggcacacag aattacttcg 120agcgaagaag aatctgataa cgaaatacag cctggcgcca tcctaaaagg taccgtagtt 180gatattaata aagactttgt cgtagttgat gttggtctga agtctgaggg agtgatccct 240atgtcagagt tcatagactc ttcagaaggt ttagtgcttg gagctgaagt agaagtctat 300ctcgaccaag ccgaagacga agagggcaaa gttgtccttt ctagagaaaa agccacacga 360caacgtcaat gggaatacat cttagctcat tgtgaagaag gttctattgt taaaggtcaa 420attacacgta aagtcaaagg cggccttatt gtagatattg gaatggaagc cttcctacct 480ggatcacaaa ttgacaacaa gaaaatcaaa aatttagatg attatgtcgg aaaagtttgt 540gaattcaaaa ttttaaaaat taacgttgaa cgtcgcaata ttgttgtctc aagaagagaa 600ctcttagaag ctgagagaat ctctaagaaa gccgaactta ttgaacaaat ttctatcgga 660gaataccgca aaggagttgt taaaaacatt actgactttg gtgtattctt agatctcgat 720ggtattgacg gtcttctcca cattaccgat atgacctgga agcgcatacg acatccttcc 780gaaatggtcg aattgaatca agagttggaa gtaattattt taagcgtaga taaagaaaaa 840ggacgagttg ctctaggtct caaacaaaaa gagcataatc cttgggaaga tattgagaag 900aaataccctc ctggaaaacg agttcttggt aaaattgtga agcttctccc ctacggagct 960ttcattgaaa ttgaagaggg cattgaaggt ctaattcaca tttctgaaat gtcttgggtg 1020aaaaatattg tagatcctag tgaagtcgta aataaaggcg atgaagttga agccattgtt 1080ctatctattc agaaggacga aggaaaaatt tctctaggat taaagcaaac agaacgtaat 1140ccttgggaca atatcgaaga aaaatatcct ataggtctcc atgtcaatgc tgaaatcaag 1200aacttaacca attacggtgc tttcgttgaa ttagaaccag gaattgaggg tctgattcat 1260atttctgaca tgagttggat taaaaaagtc tctcaccctt cagaactatt caaaaaagga 1320aattctgtag aggctgttat tttatcagta gacaaagaaa gtaaaaaaat tactttagga 1380gttaagcaat taagttctaa tccttggaat gaaattgaag ctatgttccc tgctggcaca 1440gtaatttcag gagttgtgac taaaatcact gcatttggag cctttgttga gctacaaaac 1500gggattgaag gattgattca cgtttcagaa ctttctgaca agccctttgc aaaaattgaa 1560gatattatct ccattggaga aaatgtttct gcaaaagtaa ttaagctaga tccagatcat 1620aaaaaagttt ctctttctgt aaaagaatac ttagctgaca atgcttatga tcaagactct 1680aggactgaat tagatttcaa ggattctcaa ggccctaaag agagaaagaa aaaaggaaaa 1740tag 1743<210>597<211>299<212>PRT<213>肺炎衣原体<400>597Met Leu Lys Ile Asp Leu Thr Gly Lys Val Ala Phe Val Ala Gly Ile

5 10 15Gly Asp Asp Gln Gly Tyr Gly Trp Gly Ile Ala Lys Leu Leu Ala Glu

20 25 30Ala Gly Ala Thr Ile Ile Val Gly Thr Trp Val Pro Ile Tyr Lys Ile

35 40 45Phe Ser Gln Ser Trp Glu Leu Gly Lys Phe Asn Glu Ser Arg Lys Leu

50 55 60Ser Asn Gly Thr Leu Leu Glu Ile Ala Lys Ile Tyr Pro Met Asp Ala65 70 75 80Ser Phe Asp Ser Pro Glu Asp Val Pro Glu Asp Ile Ala Glu Asn Lys

85 90 95Arg Tyr Lys Gly Ile Thr Gly Phe Thr Ile Ser Glu Val Ala Glu Gln

100 105 110Val Lys Lys Asp Phe Gly His Ile Asp Ile Leu Val His Ser Leu Ala

115 120 125Asn Ser Pro Glu Ile Ser Lys Ser Leu Leu Glu Thr Ser Arg Lys Gly

130 135 140Tyr Leu Ala Ala Leu Ser Ala Ser Ser Tyr Ser Phe Val Ser Leu Leu145 150 155 160Ser His Phe Gly Ser Ile Met Asn Arg Gly Gly Ser Thr Ile Ser Leu

165 170 175Thr Tyr Leu Ala Ser Met Arg Ala Val Pro Gly Tyr Gly Gly Gly Met

180 185 190Ser Ser Ala Lys Ala Ala Leu Glu Ser Asp Thr Lys Thr Leu Ala Trp

195 200 205Glu Ala Gly Arg Arg Trp Gly Ile Arg Val Asn Thr Ile Ser Ala Gly

210 215 220Pro Leu Ala Ser Arg Ala Gly Lys Ala Ile Gly Phe Ile Glu Arg Met225 230 235 240Val Asp Tyr Tyr Gln Glu Trp Ala Pro Ile Pro Glu Ala Met Asn Ala

245 250 255Glu Gln Val Gly Ala Val Ala Ala Phe Leu Ala Ser Pro Leu Ala Ser

260 265 270Ala Ile Thr Gly Glu Thr Leu Tyr Val Asp His Gly Ala Asn Val Met

275 280 285Gly Ile Gly Pro Glu Met Phe Pro Lys Asp Ser

290 295<210>598<211>580<212>PRT<213>肺炎衣原体<400>598Met Pro Lys Gln Ala Glu Tyr Thr Trp Gly Ser Lys Lys Ile Leu Asp

5 10 15Asn Ile Glu Cys Leu Thr Glu Asp Val Ala Glu Phe Lys Asp Leu Leu

20 25 30Tyr Thr Ala His Arg Ile Thr Ser Ser Glu Glu Glu Ser Asp Asn Glu

35 40 45Ile Gln Pro Gly Ala Ile Leu Lys Gly Thr Val Val Asp Ile Asn Lys

50 55 60Asp Phe Val Val Val Asp Val Gly Leu Lys Ser Glu Gly Val Ile Pro65 70 75 80Met Ser Glu Phe Ile Asp Ser Ser Glu Gly Leu Val Leu Gly Ala Glu

85 90 95Val Glu Val Tyr Leu Asp Gln Ala Glu Asp Glu Glu Gly Lys Val Val

100 105 110Leu Ser Arg Glu Lys Ala Thr Arg Gln Arg Gln Trp Glu Tyr Ile Leu

115 120 125Ala His Cys Glu Glu Gly Ser Ile Val Lys Gly Gln Ile Thr Arg Lys

165 170 175Gly Lys Val Cys Glu Phe Lys Ile Leu Lys Ile Asn Val Glu Arg Arg

180 185 190Asn Ile Val Val Ser Arg Arg Glu Leu Leu Glu Ala Glu Arg Ile Ser

195 200 205Lys Lys Ala Glu Leu Ile Glu Gln Ile Ser Ile Gly Glu Tyr Arg Lys

210 215 220Gly Val Val Lys Asn Ile Thr Asp Phe Gly Val Phe Leu Asp Leu Asp225 230 235 240Gly Ile Asp Gly Leu Leu His Ile Thr Asp Met Thr Trp Lys Arg Ile

245 250 255Arg His Pro Ser Glu Met Val Glu Leu Asn Gln Glu Leu Glu Val Ile

260 265 270Ile Leu Ser Val Asp Lys Glu Lys Gly Arg Val Ala Leu Gly Leu Lys

275 280 285Gln Lys Glu His Asn Pro Trp Glu Asp Ile Glu Lys Lys Tyr Pro pro

290 295 300Gly Lys Arg Val Leu Gly Lys Ile Val Lys Leu Leu Pro Tyr Gly Ala305 310 315 320Phe Ile Glu Ile Glu Glu Gly Ile Glu Gly Leu Ile His Ile Ser Glu

325 330 335Met Ser Trp Val Lys Asn Ile Val Asp Pro Ser G1u Val Val Asn Lys

34O 345 350Gly Asp G1u Val Glu Ala Ile Val Leu Ser Ile Gln Lys Asp Glu Gly

355 360 365Lys Ile Ser Leu Gly Leu Lys Gln Thr Glu Arg Asn Pro Trp Asp Asn

37O 375 380Ile Glu Glu Lys Tyr Pro Ile Gly Lau His Val Asn Ala Glu Ile Lys385 390 395 400Asn Lau Thr Asn Tyr Gly Ala Phe Val Glu Leu Glu Pro G1y Ile Glu

405 410 415Gly Leu Ile His Ile Ser Asp Met Ser Trp Ile Lys Lys Val Ser His

420 425 430Pro Ser Glu Leu Phe Lys Lys Gly Asn Ser Val Glu Ala Val Ile Leu

435 44O 445Ser Val Asp Lys Glu Ser Lys Lys Ile Thr Leu Gly Val Lys Gln Leu

450 455 460Ser Ser Asn Pro Trp Asn Glu Ile Glu Ala Met Phe Pro Ala Gly Thr465 470 475 480Val Ile Ser Gly Val Val Thr Lys Ile Thr Ala Phe Gly Ala Phe Val

485 49D 495Glu Leu Gln Asn Gly Ile Glu Gly Leu Ile His Val Ser Glu Leu Ser

500 505 510Asp Lys Pro Phe Ala Lys Ile Glu Asp Ile Ile Ser Ile Gly Glu Asn

515 520 525Val Ser Ala Lys Val Ile Lys Leu Asp Pro Asp His Lys Lys Val Ser

530 535 540Leu Ser Val Lys Glu Tyr Leu A1a Asp Asn Ala Tyr Asp Gln Asp Ser545 550 555 560Arg Thr Glu Leu Asp Phe Lys Asp Ser Gln Gly Pro Lys Glu Arg Lys

565 570 575Lys Lys Gly Lys

580<210>599<211>358<212>PRT<213>沙眼衣原体血清变型D<400>599Met Arg Lys Thr Val Ile Val Ala Met Ser Gly Gly Val Asp Ser Ser

5 10 15Val Val Ala Tyr Leu Leu Lys Lys Gln Gly Glu Tyr Asn Val Val Gly

20 25 30Leu Phe Met Lys Asn Trp Gly Glu Gln Asp Glu Asn Gly Glu Cys Thr

35 40 45Ala Thr Lys Asp Phe Arg Asp Val Glu Arg Ile Ala Glu Gln Leu Ser

50 55 60Ile Pro Tyr Tyr Thr Val Ser Phe Ser Lys Glu Tyr Lys Glu Arg Val65 70 75 80Phe Ser Arg Phe Leu Arg Glu Tyr Ala Asn Gly Tyr Thr Pro Asn Pro

85 90 95Asp Val Leu Cys Asn Arg Glu Ile Lys Phe Asp Leu Leu Gln Lys Lys

100 105 110Val Arg Glu Leu Lys Gly Asp Phe Leu Ala Thr Gly His Tyr Cys Arg

115 120 125Gly Gly Ala Asp Gly Thr Gly Leu Ser Arg Gly Ile Asp Pro Asn Lys

130 135 140Asp Gln Ser Tyr Phe Leu Cys Gly Thr Pro Lys Asp Ala Leu Ser Asn145 150 155 160Val Leu Phe Pro Leu Gly Gly Met Tyr Lys Thr Glu Val Arg Arg Ile

165 170 175Ala Gln Glu Ala Gly Leu Ala Thr Ala Thr Lys Lys Asp Ser Thr Gly

180 185 190Ile Cys Phe Ile Gly Lys Arg Pro Phe Lys Ser Phe Leu Glu Gln Phe

195 200 205Val Ala Asp Ser Pro Gly Asp Ile Ile Asp Phe Asp Thr Gln Gln Val

210 215 220Val Gly Arg His Glu Gly Ala His Tyr Tyr Thr Ile Gly Gln Arg Arg225 230 235 240Gly Leu Asi Ile Gly Gly Met Glu Lys Pro Cys Tyr Val Leu Ser Lys

245 250 255Asn Met Glu Lys Asn Ile Val Tyr Ile Val Arg Gly Glu Asp His Pro

260 265 270Leu Leu Tyr Arg Gln Glu Leu Leu Ala Lys Glu Leu Asn Trp Phe Val

275 280 285Pro Leu Gln Glu Pro Met Ile Cys Ser Ala Lys Val Arg Tyr Arg Ser

290 295 300Pro Asp Glu Lys Cys Ser Val Tyr Pro Leu Glu Asp Gly Thr Val Lys305 310 315 320Val Ile Phe Asp Val Pro Val Lys Ala Val Thr Pro Gly Gln Thr Val

325 330 335Ala Phe Tyr Gln Gly Asp Ile Cys Leu Gly Gly Gly Val Ile Glu Val

340 345 350Pro Met Ile His Gln Leu

355

Claims

1.用于引起免疫应答的组合物，包含衣原体Cap1蛋白或其免疫原性片段和免疫刺激剂。

2.权利要求1的组合物，其中免疫原性片断至少包含基本上由Cap1蛋白质第139-147位氨基酸组成的CTL表位。

3.权利要求1的组合物，其中Cap1蛋白质包含SEQ ID NO：121所示氨基酸序列或与SEQ ID NO：121所示序列有至少约90％一致性的序列。

4.权利要求1的组合物，其中Cap1蛋白或其免疫原性片断包含SEQ ID NO：121、123、125、127、129、131、133、135、137和139中任一个所示的序列。

5.权利要求1的组合物，其中免疫原性片断包含Cap1蛋白的第107-176位氨基酸。

6.权利要求5的组合物，其中免疫原性片断包含具有SEQ ID NO：121、123、125、127、129、131、133、135、137和139中任一个所示氨基酸序列的Cap1蛋白的第107-176位氨基酸。

7.权利要求1的组合物，其中免疫原性片断与感染衣原体的动物的CD8+T细胞有免疫反应性。

8.在动物中刺激衣原体特异性T细胞应答的方法，包括给动物施用有效量的权利要求1的组合物。

9.在动物中抑制衣原体感染发展的方法，包括给动物施用有效量的权利要求1的组合物。

10.用于引起免疫应答的组合物，包含编码衣原体Cap1蛋白或其免疫原性片断的分离的多核苷酸和免疫刺激剂。

11.权利要求10的组合物，其中免疫原性片断至少包含基本上由Cap1蛋白质第139-147位氨基酸组成的CTL表位。

12.权利要求10的组合物，其中Cap1蛋白质包含SEQ ID NO：121所示氨基酸序列或与SEQ ID NO：121所示序列具有至少约90％一致性的序列。

13.权利要求10的组合物，其中Cap1蛋白或其免疫原性片断包含SEQ ID NO：121、123、125、127、129、131、133、135、137和139中任一个所示的序列。

14.权利要求10的组合物，其中免疫原性片断包含Cap1蛋白的第107-176位氨基酸。

15.权利要求14的组合物，其中免疫原性片断包含具有SEQ ID NO：121、123、125、127、129、131、133、135、137和139中任一个所示氨基酸序列的Cap1蛋白的第107-176位氨基酸。

16.权利要求10的组合物，其中免疫原性片断与感染衣原体的动物的CD8+T细胞有免疫反应性。

17.权利要求10的组合物，其中分离的多核苷酸可操作地连接在病毒递送载体内。

18.权利要求17的组合物，其中病毒递送载体是痘苗病毒递送载体。

19.在动物中刺激衣原体特异性T细胞应答的方法，包括给所述动物施用有效量的权利要求10的组合物。

20.在动物中抑制衣原体感染发展的方法，包括给动物施用有效量的权利要求10的组合物。

21.在动物中抑制衣原体感染发展的方法，包括给所述动物施用有效量的权利要求18的组合物。

22.分离的多核苷酸，其包含选自下组的序列：

(a)SEQ ID NO：358-361所示序列；

(b)SEQ ID NO：358-361所示序列的互补序列；

(c)由SEQ ID NO：358-361所示序列中的至少20个连续残基组成的序列；

(d)在高严紧条件下与SEQ ID NO：358-361所示序列杂交的序列；

(e)与SEQ ID NO：358-361所示序列有至少95％一致性的序列；

(f)与SEQ ID NO：358-361所示序列有至少99％一致性的序列；和

(g)SEQ ID NO：358-361所示序列的简并变体。

23.分离的多肽，其包含选自下组的氨基酸序列：

(a)权利要求22的多核苷酸编码的序列；

(b)与权利要求22的多核苷酸所编码的序列有至少95％一致性的序列；和

(c)与权利要求22的多核苷酸所编码的序列有至少99％一致性的序列。

24.分离的多肽，其至少包含选自下组的多肽序列的免疫原性片断：

(a)SEQ ID NO：362-365所示多肽序列；

(b)与SEQ ID NO：362-365所示序列有至少95％一致性的多肽序列；和

(c)与SEQ ID NO：362-365所示序列有至少99％一致性的多肽序列。

25.包含与表达控制序列可操作地连接的权利要求22的多核苷酸的表达载体。

26.用权利要求25的表达载体转化或转染的宿主细胞。

27.特异地与权利要求23和24之任一项的多肽结合的分离的抗体，或其抗原结合片断。

28.检测患者体内是否存在衣原体的方法，包括步骤：

(a)从患者获得生物学样品；

(b)使该生物学样品与可以结合权利要求23和24之任一项的多肽的结合剂接触；

(c)检测样品中与该结合剂结合的多肽的量；

(d)将此多肽量与预先确定的截断值进行比较，由此确定出患者体内是否存在衣原体。

29.包含至少一种根据权利要求23或权利要求24的多肽的融合蛋白。

30.在高严紧条件下与SEQ ID NO：358-361所示序列杂交的寡核苷酸。

31.刺激和/或扩增衣原体蛋白质特异性T细胞的方法，包括在足以允许刺激和/或扩增T细胞的条件和时间下，使T细胞与选自下组的至少一个成分接触：

(a)权利要求23或权利要求24的多肽；

(b)权利要求22的多核苷酸；和

(c)表达权利要求22的多核苷酸的抗原呈递细胞。

32.分离的T细胞群，其包含根据权利要求31的方法制备的T细胞。

33.组合物，其包含选自生理可接受载体和免疫刺激剂的第一成分和选自下组的第二成分：

(a)权利要求23或权利要求24的多肽；

(b)权利要求22的多核苷酸；

(c)权利要求27的抗体；

(d)权利要求29的融合蛋白；

(e)权利要求32的T细胞群；和

(f)表达权利要求23或权利要求24的多肽的抗原呈递细胞。

34.刺激患者的免疫应答的方法，包括给患者施用选自下组的组合物：

(a)权利要求33的组合物；

(b)SEQ ID NO：407-430、525-559和582-598之任一个的多核苷酸序列；和

(c)SEQ ID NO：431-454和560-581之任一个的多肽序列。

35.给患者治疗衣原体感染的方法，包括给患者施用选自下组的组合物：

(a)权利要求33的组合物；

(c)SEQ ID NO：431-454和560-581之任一个的多肽序列。

36.确定患者体内是否存在衣原体的方法，包括步骤：

(a)从患者获得生物学样品；

(b)使该生物学样品与权利要求30的寡核苷酸接触；

(c)检测样品中与该寡核苷酸杂交的的多核苷酸的量；

(d)将与该寡核苷酸杂交的多核苷酸的量与预先确定的截断值进行比较，由此确定出患者体内是否存在癌症。

37.包含至少一个权利要求30的寡核苷酸的诊断试剂盒。

38.包含至少一个权利要求27的抗体和检测试剂的诊断试剂盒，其中检测试剂包含报道基团。

39.给患者治疗衣原体的方法，包括步骤：

(a)用选自下组的至少一个成分孵育分离自患者的CD4+和/或CD8+T细胞：

(i)权利要求23和24之任一项的多肽；

(ii)SEQ ID NO：431-454和560-581之任一个的多肽序列；

(iii)权利要求22的多核苷酸；

(iv)SEQ ID NO：407-430、525-559和582-598之任一个的多核苷酸序列；

(v)表达权利要求23和24之任一项的多肽序列的抗原呈递细胞；

(vi)表达SEQ ID NO：431-454和560-581之任一个的多肽序列的抗原呈递细胞，以便T细胞增殖；和

(b)给所述患者施用有效量的增殖T细胞。