ES2170136T3 - Formulaciones opioides para el tratamiento del dolor. - Google Patents
Formulaciones opioides para el tratamiento del dolor.Info
- Publication number
- ES2170136T3 ES2170136T3 ES95904755T ES95904755T ES2170136T3 ES 2170136 T3 ES2170136 T3 ES 2170136T3 ES 95904755 T ES95904755 T ES 95904755T ES 95904755 T ES95904755 T ES 95904755T ES 2170136 T3 ES2170136 T3 ES 2170136T3
- Authority
- ES
- Spain
- Prior art keywords
- dose
- opioid analgesic
- opioid
- formulation
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
LOS PACIENTES SON TRATADOS CON FORMULACIONES OPIACEAS DE LIBERACION SOSTENIDA ORAL DURANTE 24 HORAS QUE, TRAS LA ADMINISTRACION, PROPORCIONAN UNA ABSORCION DE OPIACEO INICIALMENTE RAPIDA TAL COMO LA MINIMA CONCENTRACION ANALGESICA EFECTIVA DEL OPIACEO SE REALIZA MAS RAPIDAMENTE. ESTAS FORMULACIONES OPIACEAS DE LIBERACION SOSTENIDA COMPRENDEN UNA CANTIDAD EFECTIVA DE AL MENOS UN MATERIAL RETARDANTE PARA HACER QUE DICHO ANALGESICO OPIACEO LIBERE A TAL VELOCIDAD QUE PROPORCIONE UN EFECTO ANALGESICO DESPUES DE LA ADMINISTRACION ORAL A UN PACIENTE HUMANO DURANTE AL MENOS APROXIMADAMENTE 24 HORAS, Y SE CARACTERIZAN POR PROPORCIONAR UNA ABSORCION DE DURACION MEDIA DESDE 1 A 8 HORAS APROXIMADAMENTE. TAMBIEN SE DESCRIBE UN METODO PARA TRATAR UN PACIENTE HUMANO UTILIZANDO DICHAS FORMULACIONES OPIACEAS DE LIBERACION SOSTENIDA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/156,468 US5478577A (en) | 1993-11-23 | 1993-11-23 | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US156468 | 1993-11-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2170136T3 true ES2170136T3 (es) | 2002-08-01 |
ES2170136T5 ES2170136T5 (es) | 2006-04-01 |
Family
ID=22559696
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95904755T Expired - Lifetime ES2170136T5 (es) | 1993-11-23 | 1994-11-22 | Formulaciones opioides para el tratamiento del dolor. |
ES04009845T Expired - Lifetime ES2266951T3 (es) | 1993-11-23 | 1994-11-22 | Formulaciones opioides para el tratamiento del dolor. |
ES00107670T Expired - Lifetime ES2279742T3 (es) | 1993-11-23 | 1994-11-22 | Formulaciones opioides para el tratamiento del dolor. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04009845T Expired - Lifetime ES2266951T3 (es) | 1993-11-23 | 1994-11-22 | Formulaciones opioides para el tratamiento del dolor. |
ES00107670T Expired - Lifetime ES2279742T3 (es) | 1993-11-23 | 1994-11-22 | Formulaciones opioides para el tratamiento del dolor. |
Country Status (23)
Country | Link |
---|---|
US (10) | US5478577A (es) |
EP (4) | EP1470815B1 (es) |
JP (5) | JPH09505602A (es) |
KR (1) | KR100201767B1 (es) |
CN (1) | CN1134253C (es) |
AT (3) | ATE350022T1 (es) |
AU (1) | AU693134B2 (es) |
BG (1) | BG63269B1 (es) |
CZ (1) | CZ292936B6 (es) |
DE (3) | DE69434752T2 (es) |
DK (3) | DK1470815T3 (es) |
ES (3) | ES2170136T5 (es) |
FI (1) | FI121588B (es) |
HK (1) | HK1029927A1 (es) |
HU (1) | HUT73976A (es) |
IL (1) | IL111742A (es) |
NO (1) | NO315147B1 (es) |
NZ (3) | NZ508526A (es) |
PL (1) | PL312587A1 (es) |
PT (3) | PT731694E (es) |
SK (1) | SK283544B6 (es) |
TW (1) | TW420617B (es) |
WO (1) | WO1995014460A1 (es) |
Families Citing this family (226)
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US5460972A (en) * | 1991-04-08 | 1995-10-24 | Research Foundation Of The State University Of New York | Ionized magnesium2+ concentrations in biological samples |
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
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US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
CA2147759C (en) * | 1992-10-26 | 2004-08-10 | Wolfgang Herrmann | Tilidin dihydrogen orthophosphate, method of preparing it and pharmaceutical preparations containing it |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
SE9301057L (sv) † | 1993-03-30 | 1994-10-01 | Pharmacia Ab | Beredning med kontrollerad frisättning |
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US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
US7740881B1 (en) * | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
EP0672416A1 (en) * | 1994-03-14 | 1995-09-20 | Euro-Celtique S.A. | Pharmaceutical composition comprising diamorphine |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US5411745A (en) * | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
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US7060293B1 (en) | 1994-05-25 | 2006-06-13 | Purdue Pharma | Powder-layered oral dosage forms |
US5914131A (en) * | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US20020006438A1 (en) * | 1998-09-25 | 2002-01-17 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
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US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
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1993
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1994
- 1994-11-22 DE DE69434752T patent/DE69434752T2/de not_active Expired - Lifetime
- 1994-11-22 NZ NZ508526A patent/NZ508526A/xx not_active IP Right Cessation
- 1994-11-22 EP EP04009845A patent/EP1470815B1/en not_active Expired - Lifetime
- 1994-11-22 WO PCT/US1994/013606 patent/WO1995014460A1/en active IP Right Grant
- 1994-11-22 AT AT00107670T patent/ATE350022T1/de not_active IP Right Cessation
- 1994-11-22 NZ NZ277917A patent/NZ277917A/en not_active IP Right Cessation
- 1994-11-22 CN CNB941927237A patent/CN1134253C/zh not_active Expired - Fee Related
- 1994-11-22 HU HU9503468A patent/HUT73976A/hu active IP Right Revival
- 1994-11-22 NZ NZ336055A patent/NZ336055A/xx not_active IP Right Cessation
- 1994-11-22 AT AT04009845T patent/ATE327739T1/de not_active IP Right Cessation
- 1994-11-22 US US08/578,688 patent/US5672360A/en not_active Expired - Lifetime
- 1994-11-22 CZ CZ19953217A patent/CZ292936B6/cs not_active IP Right Cessation
- 1994-11-22 PT PT95904755T patent/PT731694E/pt unknown
- 1994-11-22 EP EP95904755A patent/EP0731694B2/en not_active Expired - Lifetime
- 1994-11-22 PL PL94312587A patent/PL312587A1/xx unknown
- 1994-11-22 DK DK04009845T patent/DK1470815T3/da active
- 1994-11-22 AT AT95904755T patent/ATE212831T1/de not_active IP Right Cessation
- 1994-11-22 EP EP06026995A patent/EP1776950A1/en not_active Ceased
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- 1994-11-22 DK DK00107670T patent/DK1023896T3/da active
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- 1994-11-22 JP JP7515254A patent/JPH09505602A/ja active Pending
- 1994-11-22 ES ES95904755T patent/ES2170136T5/es not_active Expired - Lifetime
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- 1994-11-22 DK DK95904755T patent/DK0731694T4/da active
- 1994-11-22 DE DE69429826T patent/DE69429826T3/de not_active Expired - Lifetime
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- 1994-11-22 AU AU13313/95A patent/AU693134B2/en not_active Withdrawn - After Issue
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- 1994-12-21 TW TW083111985A patent/TW420617B/zh active
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1996
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1997
- 1997-09-26 US US08/938,898 patent/US20020058050A1/en not_active Abandoned
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2001
- 2001-02-02 HK HK01100760A patent/HK1029927A1/xx not_active IP Right Cessation
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- 2002-06-04 US US10/162,132 patent/US20030035837A1/en not_active Abandoned
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2004
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2007
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