US20100209351A1 - Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level - Google Patents

Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level Download PDF

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US20100209351A1
US20100209351A1 US12/653,109 US65310909A US2010209351A1 US 20100209351 A1 US20100209351 A1 US 20100209351A1 US 65310909 A US65310909 A US 65310909A US 2010209351 A1 US2010209351 A1 US 2010209351A1
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beads
opioid
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sustained release
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Richard S. Sackler
Robert F. Kaiko
Paul Goldenheim
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • the present invention relates to bioavailable sustained-release pharmaceutical formulations of analgesic drugs, in particular opioid analgesics, which provide an extended duration of effect when orally administered.
  • sustained-release preparations It is the intent of all sustained-release preparations to provide a longer period of pharmacologic response after the administration of the drug than is ordinarily experienced after the administration of the rapid release dosage forms. Such longer periods of response provide for many inherent therapeutic benefits that are not achieved with corresponding short acting, immediate release preparations. This is especially true in the treatment of cancer patients or other patients in need of treatment for the alleviation of moderate to severe pain, where blood levels of an opioid analgesic medicament must be maintained at a therapeutically effective level to provide pain relief.
  • compositions providing the sustained-release of an active compound from a carrier is basically concerned with the release of the active substance into the physiologic fluid of the alimentary tract.
  • mete presence of an active substance in the gastrointestinal fluids does not, by itself, insure bioavailability.
  • the active drug substance In order to be absorbed, the active drug substance must be in solution.
  • the dissolution time required for a given proportion of an active substance from a unit dosage form is determined as the proportion of the amount of active drug substance released from a unit dosage form over a specified time base by a test method conducted under standardized conditions.
  • the physiologic fluids of the gastrointestinal tract are the media for determining dissolution time.
  • the present state of the art recognizes many satisfactory test procedures to measure dissolution time for pharmaceutical compositions, and these test procedures are described in official compendia world wide.
  • the primary principle guiding the use of opioid analgesics in the management of chronic pain is the individualization of dosages to meet the different and changing opioid requirements among and within each individual patient. Pain management authorities stress the importance of titration. Titration to the appropriate dose for a particular patient is necessitated by the wide inter-individual differences in the response of different patients to given doses of opioids. While a multitude of factors are responsible for wide inter-individual differences in the response to opioid analgesics, one important factor is rooted in the wide inter-individual variation in metabolism and pharmacokinetics.
  • opioids which are most efficiently titrated are those with relatively short elimination half-lives in the range of 3 to 5 hours (e.g., morphine, hydromorphone, oxycodone) as compared to long (12 to 72 hours) and more variable half-life analgesics (e.g., methadone, levorphanol).
  • the shorter half life drugs approach steady-state concentrations in approximately a day rather than in several days to a week or more. Only at steady-state can one expect that the balance between efficacy and side effects will persist at a given dosing schedule. Having confidence that the patient is at approximate steady-state a day or so following initiation of dosing allows for much quicker assessment of whether the dosage is appropriate for that individual.
  • sustained-release opioid analgesic preparation which provides appropriate pharmacokinetic parameters (e.g., absorption profile) and accompanying pharmacodynamic response in the patient (e.g., relief from pain) such that the same dosage form may be used to both titrate a patient receiving opioid analgesic therapy and used in chronic maintenance therapy after titration of the patient.
  • the sustained-release preparations will provide a duration of effect lasting longer than about twelve hours such that a drug that may be administered to a patient only once a day.
  • the sustained release dosage form will not only provide effective pain relief for a duration of greater than about 12 hours, but will additionally provide a pharmacokinetic and pharmacodynamic profile which will allow a patient who is to receive opioid analgesic therapy to be titrated and chronically treated with the same sustained-release dosage form.
  • oral opioid analgesic formulations that are currently available in the market must be administered every four to six hours daily; a selected few are formulated for less frequent 12 hour dosing.
  • Morphine which is considered to be the prototypic opioid analgesic, has been formulated into twice-daily controlled-release formulations (i.e., MS Contin® tablets, commercially available from Purdue Frederick Company; and Kapanol®, commercially available from F.H. Faulding and Company; and Oramorph® SR, previously referred to as Roxanol® SR, commercially available from Roxane).
  • An orally administrable opioid formulation which would provide an extended duration of analgesia without higher incidence of adverse effects would be highly desirable.
  • Such an oral sustained-release formulation of an opioid analgesic would be bioavailable and provide effective steady-state blood levels (e.g., plasma levels) of the drug when orally administered such that a duration of analgesic efficacy about 24 hours or more is obtained.
  • the present invention is related in part to the surprising discovery that in order to provide a 24 hour dosage form of an opioid analgesic, it is critical to formulate a sustained release formulation in pain with an analgesic preparation which provides an initially rapid opioid release so that the minimum effective analgesic concentration can be quickly approached in many patients who have measurable if not significant pain at the time of dosing.
  • a single dosage form according to the present invention to titrate a patient receiving opioid analgesic therapy while providing sustained-release of an opioid analgesic to once-a-day sustained release oral dosage opioid formulations which comprise an opioid analgesic and an effective amount of at least one retardant material to cause the opioid analgesic to be released at an effective rate to provide an analgesic effect after oral administration to a human patient for at least about 24 hours.
  • inventive formulations when administered in humans, provide an initially rapid rate of rise in the plasma concentration of the opioid characterized by providing an absorption half-life from 1.5 to about 8 hours.
  • inventive once-daily oral sustained release formulations provides an absorption half-life from 2 to about 4 hours.
  • the present invention is also directed to a method for titrating human patients with a sustained release oral opioid formulation.
  • the first step of this method comprises administering to a human patient on a once-a-day basis a unit dose of the inventive once-a-day oral sustained release opioid formulations described above and in the following paragraphs.
  • the method includes the further step of monitoring pharmacokinetic and pharmacodynamic parameters elicited by said formulation in said human patient and determining whether said pharmacokinetic and/or pharmacodynamic parameters are appropriate to treat said patient on a repeated basis.
  • the patient is titrated by adjusting the dose of said opioid analgesic administered to the patient by administering a unit dose of said sustained release opioid analgesic formulation containing a different amount of opioid analgesic if it is determined that said pharmacokinetic and/or said pharmacodynamic parameters are not satisfactory or maintaining the dose of said opioid analgesic in the unit dose at a previously administered amount if said pharmacokinetic and/or pharmacodynamic parameters are deemed appropriate.
  • the titration is continued by further adjusting the dose of the opioid analgesic until appropriate steady-state pharmacokinetic/pharmacodynamic parameters are achieved in the patient. Thereafter, the administration of the dose of the opioid analgesic in the oral sustained release formulation is continued on a once-a-day basis until treatment is terminated.
  • bioavailability is defined for purposes of the present invention as the extent to which the drug (e.g., opioid analgesic) is absorbed from the unit dosage forms.
  • sustained release is defined for purposes of the present invention as the release of the drug (e.g., opioid analgesic) at such a rate that blood (e.g., plasma) levels are maintained within the therapeutic range but below toxic levels over a period of time of about 24 hours or longer.
  • drug e.g., opioid analgesic
  • blood e.g., plasma
  • rapid rate of rise with regard to opioid plasma concentration is defined for purposes of the present invention as signifying that the formulation provides a T 1/2 (abs), or half-life of absorption, from 1.5 about hours to about 8 hours.
  • T 1/2 (abs) is defined for purposes of the present invention as the amount of time necessary for one-half of the absorbable dose of opioid to be transferred to plasma. This value is calculated as a “true” value (which would take into account the effect of elimination processes), rather than an “apparent” absorption half-life.
  • steady state means that a plasma level for a given drug has been achieved and which is maintained with subsequent doses of the drug at a level which is at or above the minimum effective therapeutic level and is below the minimum toxic plasma level for a given drug.
  • the minimum effective therapeutic level will be a partially determined by the amount of pain relief achieved in a given patient. It will be well understood by those skilled in the medical art that pain measurement is highly subjective and great individual variations may occur among patients.
  • maintenance therapy and “chronic therapy” are defined for purposes of the present invention as the drug therapy administered to a patient after a patient is titrated with an opioid analgesic to a steady state as defined above.
  • FIG. 1 is a graphical representation of the mean sedation vs. time curve for Example 1 (fasted);
  • FIG. 2 is a graphical representation of the mean sedation vs. time curve for Example 2 (fasted);
  • FIG. 3 is a graphical representation of the mean respiratory rate vs. time curve for Example 1 (fasted);
  • FIG. 4 is a graphical representation of the mean respiratory rate vs. time curve for Example 2 (fasted);
  • FIG. 5 is a graphical representation of the mean pupil size v. time curve for Example 1 (fasted);
  • FIG. 6 is a graphical representation of the mean pupil size vs. time curve for Example 2 (fasted);
  • FIG. 7 is a graphical representation of the means subject questionnaire vs. time curve for Example 1 (fasted);
  • FIG. 8 is a graphical representation of the means subject questionnaire vs. time curve for Example 2 (fasted);
  • FIG. 9 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 1 (fed and fasted) and Example 2 (fasted);
  • FIG. 10 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 3 (fed and fasted);
  • FIG. 11 is a graphical representation of the mean sedation vs. time curve for Example 3 (fasted).
  • FIG. 12 is a graphical representation of the mean respiratory rate vs. time curve for Example 3 (fasted).
  • FIG. 13 is a graphical representation of the mean pupil size v. time curve for Example 3 (fasted).
  • FIG. 14 is a graphical representation of the mean subject modified specific drug effect questionnaire vs. time curve for Example 2 (fasted).
  • analgesic plasma opioid e.g., morphine
  • MEAC minimum effective analgesic concentration
  • the inventive sustained release once-a-day formulations may be characterized by the fact that they are designed to provide an initially rapid rate of rise in the plasma concentration of said opioid characterized by providing an absorption half-life from about 1 to about 8 hours, when the oral sustained release formulation is administered in the fasted state (i.e., without food).
  • the absorption half-life is preferably from about 1 to about 6 hours, and more preferably from about 1 to about 3 hours.
  • the inventive formulations may be further characterized by having a surprisingly fast time to peak drug plasma concentration (i.e., t max ).
  • t max of the sustained release formulations of the present invention may be from about 2 to about 10 hours. In certain preferred embodiments, the t max provided by these formulations may be from about 4 to about 9 hours.
  • the administration of 24-hour opioid oral sustained release formulations in accordance with the present invention reveals a greater degree of intensity of certain pharmacodynamic endpoints during the earlier portions of the plasma concentration curve (e.g., 4-8 hours after oral administration), such as sedation respiratory rate, pupil size, and/or combined scores from a questionnaire of opioid effects reported by the subjects at serial times following each treatment (i.e., administration of the oral dosage form).
  • Other measures of analgesic efficacy such as sum of pain intensity difference (SPID) and total pain relief (TOTPAR) have consistently higher numerical scores via the presently claimed methods, while also generating in many cases fewer adverse events (which in general are predominantly mild or moderate somnolence, nausea and/or dizziness).
  • Opioid analgesic compounds which may be used in the present invention include alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, cyclazocine, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levallorphan, levorphanol, levophenacyl
  • the opioid analgesic may be in the form of the free base, a salt, a complex, etc.
  • the opioid analgesic is selected from the group consisting of hydromorphone, oxycodone, dihydrocodeine, codeine, dihydromorphine, morphine, buprenorphine, salts of any of the foregoing, and mixtures of any of the foregoing.
  • the sustained-release opioid oral dosage form of the present invention includes hydromorphone as the therapeutically active ingredient in an amount from about 4 to about 64 mg hydromorphone hydrochloride.
  • the opioid analgesic comprises morphine
  • the sustained release oral dosage forms of the present invention include form about 5 mg to about 800 mg morphine, by weight.
  • the dosage form may contain molar equivalent amounts of other hydromorphone or morphine salts or of the base.
  • the maximum plasma concentration is from about 2 ng/ml to about 14 ng/ml, and preferably is from about 3 ng/ml to about 8 ng/ml, based on a 30 mg dose of morphine sulfate.
  • the opioid analgesic comprises oxycodone
  • the sustained release oral dosage forms of the present invention include from about 5 mg to about 400 mg oxycodone.
  • the dosage form contains an appropriate amount of another of the opioid analgesics to provide a substantially equivalent therapeutic effect.
  • the sustained release dosage forms of the present invention generally achieve and maintain therapeutic levels substantially without significant increases in the intensity and/or degree of concurrent side effects, such as nausea, vomiting or drowsiness, which are often associated with high blood levels of opioid analgesics. There is also evidence to suggest that the use of the present dosage forms leads to a reduced risk of drug addiction. Furthermore, the sustained release dosage forms of the present invention preferably releases the opioid analgesic at a rate that is independent of pH, e.g., between pH 1.6 and 7.2. In other words, the dosage forms of the present invention avoid “dose dumping” upon oral administration.
  • the oral opioid analgesics have been formulated to provide for an increased duration of analgesic action allowing once-daily dosing.
  • these formulations at comparable daily dosages of conventional immediate release drug, are associated with a lower incidence in severity of adverse drug reactions and can also be administered at a lower daily dose than conventional oral medication while maintaining pain control.
  • the retardant material utilized in the sustained release formulations of the invention may be one which is known in the art, including but not limited to acrylic polymers, alkylcelluloses, shellac, zein, hydrogenated vegetable oil, hydrogenated castor oil, and mixtures of any of the foregoing.
  • the sustained release opioid dosage forms comprise a plurality of substrates comprising the active ingredient, which substrates are coated with a sustained release coating comprising a retardant material.
  • the coating formulations of the present invention should be capable of producing a strong, continuous film that is smooth and elegant, capable of supporting pigments and other coating additives, non-toxic, inert, and tack-free.
  • the sustained release preparations of the present invention may be used in conjunction with any multiparticulate system, such as beads, spheroids, microspheres, seeds, pellets, ion-exchange resin beads, and other multi-particulate systems in order to obtain a desired sustained release of the therapeutically active agent.
  • Beads, granules, spheroids, or pellets, etc., prepared in accordance with the present invention can be presented in a capsule or in any other suitable unit dosage form.
  • the inert pharmaceutical beads may be from about 8 mesh to about 50 mesh.
  • the beads are, e.g., nu pariel 18/20 beads.
  • the sustained release opioid dosage forms comprise a plurality of substrates comprising the active ingredient, which substrates are coated with a sustained release coating.
  • the coating formulations of the present invention should be capable of producing a strong, continuous film that is smooth and elegant, capable of supporting pigments and other coating additives, non-toxic, inert, and tack-free.
  • the substrate comprising the therapeutically active agent may be coated with a sufficient amount of hydrophobic material to obtain a weight gain level from about 2 to about 30 percent, although the overcoat may be greater depending upon the physical properties of the particular opioid analgesic compound utilized and the desired release rate, among other things.
  • the substrate comprising the therapeutically active agent may be coated with a sufficient amount of retardant material to obtain a weight gain level from about 2 to about 30 percent, although the overcoat may be greater depending upon the physical properties of the particular opioid analgesic compound utilized and the desired release rate, among other things.
  • the solvent which is used for the retardant material which is typically hydrophobic, may be any pharmaceutically acceptable solvent, including water, methanol, ethanol, methylene chloride and mixtures thereof. It is preferable however, that the coatings be based upon aqueous dispersions of the hydrophobic material.
  • the hydrophobic polymer comprising the sustained release coating is a pharmaceutically acceptable acrylic polymer, including but not limited to acrylic acid and methacrylic acid copolymers, methyl methacrylate copolymers, ethoxyethyl methacrylates, cyanoethyl methacrylate, aminoalkyl methacrylate copolymer, poly(acrylic acid), poly(methacrylic acid), methacrylic acid alkylamide copolymer, poly(methyl methacrylate), poly(methacrylic acid anhydride), methyl methacrylate, polymethacrylate, poly(methyl methacrylate) copolymer, polyacrylamide, aminoalkyl methacrylate copolymer and glycidyl methacrylate copolymers.
  • acrylic acid and methacrylic acid copolymers including but not limited to acrylic acid and methacrylic acid copolymers, methyl methacrylate copolymers, ethoxyethyl methacrylates, cyanoe
  • the acrylic polymer is comprised of one or more ammonio methacrylate copolymers.
  • Ammonio methacrylate copolymers are well known in the art, and are described in NF XVII as fully polymerized copolymers of acrylic and methacrylic acid esters with a low content of quaternary ammonium groups.
  • the acrylic coating is an acrylic resin lacquer used in the form of an aqueous dispersion, such as that which is commercially available from Rohm Pharma under the Tradename Eudragit®.
  • the acrylic coating comprises a mixture of two acrylic resin lacquers commercially available from Rohm Pharma under the Tradenames Eudragit® RL 30 D and Eudragit® RS 30 D, respectively.
  • Eudragit® RL 30 D and Eudragit® RS 30 D are copolymers of acrylic and methacrylic esters with a low content of quaternary ammonium groups, the molar ratio of ammonium groups to the remaining neutral (meth)acrylic esters being 1:20 in Eudragit® RL 30 D and 1:40 in Eudragit® RS 30 D.
  • the mean molecular weight is about 150,000.
  • the code designations RL (high permeability) and RS (low permeability) refer to the permeability properties of these agents.
  • Eudragit® RL/RS mixtures are insoluble in water and in digestive fluids. However, coatings formed from the same are swellable and permeable in aqueous solutions and digestive fluids.
  • the Eudragit® RL/RS dispersions of the present invention may be mixed together in any desired ratio in order to ultimately obtain a sustained release formulation having a desirable dissolution profile. Desirable sustained release formulations may be obtained, for instance, from a retardant coating derived from 100% Eudragit® RL, 50% Eudragit® RL and 50% Eudragit® RS, and 10% Eudragit® RL:Eudragit® 90% RS. Of course, one skilled in the art will recognize that other acrylic polymers may also be used, such as, for example, Eudragit® L.
  • the hydrophobic polymer which may be used for coating the substrates of the present invention is a hydrophobic alkyl cellulosic material such as ethylcellulose.
  • ethylcellulose a hydrophobic alkyl cellulosic material
  • cellulosic polymers including other alkyl cellulosic polymers, may be substituted for part or all of the ethylcellulose included in the hydrophobic polymer coatings of the present invention.
  • Aquacoat® One commercially available aqueous dispersion of ethylcellulose is Aquacoat® (FMC Corp., Philadelphia, Pa., U.S.A.). Aquacoat® is prepared by dissolving the ethylcellulose in a water-immiscible organic solvent and then emulsifying the same in water in the presence of a surfactant and a stabilizer. After homogenization to generate submicron droplets, the organic solvent is evaporated under vacuum to form a pseudolatex. The plasticizer is not incorporated in the pseudolatex during the manufacturing phase. Thus, prior to using the same as a coating, it is necessary to intimately mix the Aquacoat® with a suitable plasticizer prior to use.
  • aqueous dispersion of ethylcellulose is commercially available as Surelease® (Colorcon, Inc., West Point, Pa., U.S.A.). This product is prepared by incorporating plasticizer into the dispersion during the manufacturing process. A hot melt of a polymer, plasticizer (dibutyl sebacate), and stabilizer (oleic acid) is prepared as a homogeneous mixture, which is then diluted with an alkaline solution to obtain an aqueous dispersion which can be applied directly onto substrates.
  • Surelease® Colorcon, Inc., West Point, Pa., U.S.A.
  • the inclusion of an effective amount of a plasticizer in the aqueous dispersion of hydrophobic polymer will further improve the physical properties of the film.
  • a plasticizer included in a coating solution is based on the concentration of the film-former, e.g., most often from about 1 to about 50 percent by weight of the film-former. Concentration of the plasticizer, however, can only be properly determined after careful experimentation with the particular coating solution and method of application.
  • suitable plasticizers for ethylcellulose include water insoluble plasticizers such as dibutyl sebacate, diethyl phthalate, triethyl citrate, tributyl citrate, and triacetin, although it is possible that other water-insoluble plasticizers (such as acetylated monoglycerides, phthalate esters, castor oil, etc.) may be used. Triethyl citrate is especially preferred.
  • plasticizers for the acrylic polymers of the present invention include citric acid esters such as triethyl citrate NF XVI, tributyl citrate, dibutyl phthalate, and possibly 1,2-propylene glycol, polyethylene glycols, propylene glycol, diethyl phthalate, castor oil, and triacetin, although it is possible that other water-insoluble plasticizers (such as acetylated monoglycerides, phthalate esters, castor oil, etc.) may be used. Triethyl citrate is especially preferred.
  • the sustained release profile of the formulations of the invention can be altered, for example, by varying the thickness of the hydrophobic coating, changing the particular hydrophobic material used, or altering the relative amounts of, e.g., different acrylic resin lacquers, altering the manner in which the plasticizer is added (e.g., when the sustained release coating is derived from an aqueous dispersion of hydrophobic polymer), by varying the amount of plasticizer relative to hydrophobic polymer, by the inclusion of additional ingredients or excipients, by altering the method of manufacture, etc.
  • Sustained release spheroids or beads, coated with an opioid may be prepared, e.g. by dissolving the opioid analgesic in water and then spraying the solution onto a substrate, for example, nu pariel 18/20 beads, using a Wurster insert.
  • additional ingredients are also added prior to coating the beads in order to assist the opioid binding to the substrates, and/or to color the solution, etc.
  • a product which includes hydroxypropyl methylcellulose, etc. with or without colorant may be added to the solution and the solution mixed (e.g., for about 1 hour) prior to application of the same onto the beads.
  • the resultant coated substrate in this example beads, may then be optionally overcoated with a barrier agent, to separate the therapeutically active agent from the hydrophobic sustained release coating.
  • a barrier agent is one which comprises hydroxypropyl methylcellulose.
  • any film-former known in the art may be used. It is preferred that the barrier agent does not affect the dissolution rate of the final product.
  • the opioid, HPMC protected (optional) beads may then be overcoated with hydrophobic polymer, preferably with an effective amount of plasticizer.
  • the coating solutions of the present invention preferably contain, in addition to the film-former, plasticizer, and solvent system (i.e., water), a colorant to provide elegance and product distinction. Color may be added to the solution of the therapeutically active agent instead, or in addition to the aqueous dispersion of hydrophobic polymer.
  • solvent system i.e., water
  • the plasticized aqueous dispersion of hydrophobic polymer may be applied onto the substrate comprising the therapeutically active agent by spraying using any suitable spray equipment known in the art.
  • a Wurster fluidized-bed system is used in which an air jet, injected from underneath, fluidizes the core material and effects drying while the acrylic polymer coating is sprayed on.
  • a further overcoat of a film-former such as Opadry®, is optionally applied to the beads. This overcoat is provided, if at all, in order to substantially reduce agglomeration of the beads.
  • the coated beads are cured in order to obtain a stabilized release rate of the therapeutically active agent.
  • the coated substrate is preferably subjected to curing at a temperature greater than the glass transition temperature of the coating solution (i.e., ethylcellulose) and at a relative humidity from about 60% to about 100%, until the curing endpoint is reached, e.g., about 60° C. and a relative humidity from about 60% to about 100% for a time period from about 48 to about 72 hours, as described in U.S. Pat. No. 5,273,760, hereby incorporated by reference.
  • a temperature greater than the glass transition temperature of the coating solution i.e., ethylcellulose
  • a relative humidity from about 60% to about 100%
  • a stabilized product is obtained by subjecting the coated substrate to oven curing at a temperature above the Tg of the plasticized acrylic polymer for the required time period, the optimum values for temperature and time for the particular formulation being determined experimentally.
  • the stabilized product is obtained via an oven curing conducted at a temperature of about 45° C. for a time period from about 24 to about 48 hours or longer, as described in U.S. Pat. No. 5,286,493, hereby incorporated by reference.
  • the release of the therapeutically active agent from the sustained-release formulation of the present invention can be further influenced, i.e., adjusted to a desired rate, by the addition of one or more release-modifying agents, or by providing one or more passageways through the coating.
  • the ratio of hydrophobic polymer to water soluble material is determined by, among other factors, the release rate required and the solubility characteristics of the materials selected.
  • the release-modifying agents which function as pore-formers may be organic or inorganic, and include materials that can be dissolved, extracted or leached from the coating in the environment of use.
  • the pore-formers may comprise one or more hydrophilic polymers such as hydroxypropylmethylcellulose.
  • the sustained release coatings of the present invention can also include erosion-promoting agents such as starch and gums.
  • the sustained release coatings of the present invention can also include materials useful for making microporous lamina in the environment of use, such as polycarbonates comprised of linear polyesters of carbonic acid in which carbonate groups reoccur in the polymer chain.
  • the release-modifying agent may also comprise a semi-permeable polymer.
  • the release-modifying agent is selected from hydroxypropylmethylcellulose, lactose, metal stearates, and mixtures of any of the foregoing.
  • the sustained release coatings of the present invention may also include an exit means comprising at least one passageway, orifice, or the like.
  • the passageway may be formed by such methods as those disclosed in U.S. Pat. Nos. 3,845,770; 3,916,889; 4,063,064; and 4,088,864 (all of which are hereby incorporated by reference).
  • the passageway can have any shape such as round, triangular, square, elliptical, irregular, etc.
  • the present invention may utilize a multiparticulate sustained release matrix.
  • Suitable materials for inclusion in a sustained release matrix are
  • Hydrophilic polymers such as gums, cellulose ethers, acrylic resins and protein derived materials. Of these polymers, the cellulose ethers, especially hydroxyalkylcelluloses and carboxyalkylcelluloses, are preferred.
  • the oral dosage form may contain between 1% and 80% (by weight) of at least one hydrophilic or hydrophobic polymer.
  • the oral dosage form may contain up to 60% (by weight) of at least one digestible, long chain hydrocarbon.
  • the oral dosage form may contain up to 60% (by weight) of at least one polyalkylene glycol.
  • a suitable matrix may be one which comprises at least one water soluble hydroxyalkyl cellulose, at least one C 12 -C 36 , preferably C 14 -C 22 , aliphatic alcohol and, optionally, at least one polyalkylene glycol.
  • the at least one hydroxyalkyl cellulose is preferably a hydroxy (C 1 to C 6 ) alkyl cellulose, such as hydroxypropylcellulose, hydroxypropylmethylcellulose and, especially, hydroxyethyl cellulose.
  • the amount of the at least one hydroxyalkyl cellulose in the present oral dosage form will be determined, inter alia, by the precise rate of opioid release required.
  • the at least one aliphatic alcohol may be, for example, lauryl alcohol, myristyl alcohol or stearyl alcohol. In certain preferred embodiments, the at least one aliphatic alcohol is cetyl alcohol or cetostearyl alcohol.
  • the amount of the at least one aliphatic alcohol in the present oral dosage form will be determined, as above, by the precise rate of opioid release required. It will also depend on whether at least one polyalkylene glycol is present in or absent from the oral dosage form. In the absence of at least one polyalkylene glycol, the oral dosage form preferably contains between 20% and 50% (by wt) of the at least one aliphatic alcohol. When at least one polyalkylene glycol is present in the oral dosage form, then the combined weight of the at least one aliphatic alcohol and the at least one polyalkylene glycol preferably constitutes between 20% and 50% (by wt) of the total dosage.
  • the ratio of, e.g., at least one hydroxyalkyl cellulose or acrylic resin to at least one aliphatic alcohol/polyalkylene glycol determines, to a considerable extent, the release rate of the opioid from the formulation.
  • a ratio of the at least one hydroxyalkyl cellulose to at least one aliphatic alcohol/polyalkylene glycol of between 1:2 and 1:4 is preferred, with a ratio of between 1:3 and 1:4 being particularly preferred.
  • At least one polyalkylene glycol may be, for example, polypropylene glycol or, preferably, polyethylene glycol.
  • the number average molecular weight of the at least one polyalkylene glycol is preferred between 1000 and 15000 especially between 1500 and 12000.
  • Another suitable sustained release matrix would comprise an alkylcellulose (especially ethyl cellulose), a C 12 to C 36 aliphatic alcohol and, optionally, a polyalkylene glycol.
  • a sustained release matrix may also contain suitable quantities of other materials, e.g., diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art.
  • sustained release matrices may be prepared, for example, by
  • the granules are formed by wet granulating the hydroxyalkyl cellulose/opioid with water.
  • the amount of water added during the wet granulation step may be, e.g., between 1.5 and 5 times, especially between 1.75 and 3.5 times, the dry weight of the opioid.
  • a spheronizing agent together with the active ingredient can be spheronized to form spheroids.
  • Microcrystalline cellulose is preferred, although hydrous lactose impalpable is preferably utilized for morphine sulfate sustained release formulations prepared by powder-layering techniques.
  • a suitable microcrystalline cellulose is, for example, the material sold as Avicel PH 101 (Trade Mark, FMC Corporation).
  • the spheroids may also contain a binder. Suitable binders, such as low viscosity, water soluble polymers, will be well known to those skilled in the pharmaceutical art.
  • the sustained release coating will generally include a water insoluble material such as (a) a wax, either alone or in admixture with a fatty alcohol; or (b) shellac or zein.
  • the substrates of the present invention may also be prepared via a melt pellitization technique.
  • the opioid in finely divided form is combined with a binder (also in particulate form) and other optional inert ingredients, and thereafter the mixture is pelletized, e.g., by mechanically working the mixture in a high shear mixer to form the pellets (granules, spheres). Thereafter, the pellets (granules, spheres) may be sieved in order to obtain pellets of the requisite size.
  • the binder material is preferably in particulate form and has a melting point above about 40° C. Suitable binder substances include, for example, hydrogenated castor oil, hydrogenated vegetable oil, other hydrogenated fats, fatty alcohols, fatty acid esters, fatty acid glycerides, and the like.
  • an effective amount of opioid in immediate release form is included in the 24 hour sustained release unit dose opioid formulation to be administered.
  • the immediate release form of the opioid is included in an amount which is effective to shorten the time to maximum concentration of the opioid in the blood (e.g., plasma).
  • an effective amount of the opioid in immediate release form may be coated onto the substrates of the present invention.
  • the immediate release layer would be overcoated on top of the controlled release coating.
  • the immediate release layer may be coated onto the surface of substrates wherein the opioid is incorporated in a controlled release matrix.
  • the immediate release portion of the opioid dose may be incorporated into the gelatin capsule via inclusion of the sufficient amount of immediate release opioid as a powder or granulate within the capsule.
  • the gelatin capsule itself may be coated with an immediate release layer of the opioid.
  • One skilled in the art would recognize still other alternative manners of incorporating the immediate release opioid portion into the unit dose. Such alternatives are deemed to be encompassed by the appended claims. It has been discovered that by including such an effective amount of immediate release opioid in the unit dose, the experience of relatively higher levels of pain in patients is significantly reduced.
  • the dosage form may be provided by preparing a dosage form consistent with one of the above described methods or by other means known to those skilled in the pharmaceutical art.
  • the sustained release opioid formulations may also be manufactured as tablets.
  • the tablet may contain, in addition to the opioid and the retardant material, suitable quantities of other materials, e.g. diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art in amounts up to about 50% by weight of the particulate if desired.
  • suitable quantities of other materials e.g. diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art in amounts up to about 50% by weight of the particulate if desired.
  • Specific examples of pharmaceutically acceptable carriers and excipients that may be used to formulate oral dosage forms are described in the Handbook of Pharmaceutical Excipients , American Pharmaceutical Association (1986), incorporated by reference herein.
  • a plurality of blood samples are taken from the patient over the course of the dosing interval.
  • the samples thus obtained are then tested to determine the plasma level of the opioid analgesic, and any active metabolites thereof.
  • the values thus obtained may then be utilized to determine additional pharmacokinetic parameters.
  • a determination as to whether the patient has obtained an adequate pharmacodynamic response with said dosage form will be made, e.g., reference to predetermined blood levels, comparison of the results subjective pain tests given to the patient, the adverse effect profile of the drug in the patient, or the like.
  • a determination may then be made as to whether an upward or downward adjustment of the dose is necessary.
  • the administration of the sustained release unit dosage form is continued over the dosing interval of the unit dose to maintain an adequate pharmacodynamic response with the sustained release dosage form.
  • the adequate pharmacodynamic response will last between about 12 and about 24 hours, most preferably about 24 hours or greater.
  • the administration of the sustained release unit dosage form is continued over the dosing interval of the unit dose to maintain said adequate pharmacodynamic response with said sustained release dosage form.
  • a patient may be titrated with a sustained release opioid analgesic dosage form. Subsequent maintenance therapy may be provided with the same sustained release dosage form.
  • Example 1 morphine sulfate sustained-release beads with a 5% w/w sustained release coating comprising Eudragit® RS were prepared, including a 10% immediate release morphine sulfate overcoat.
  • Example 2 morphine sulfate sustained-release beads with an 8% w/w sustained-release coating comprising Eudragit® RS were prepared, including a 10% immediate release morphine sulfate overcoat.
  • Morphine sulfate beads were first manufactured using a rotor processing technique.
  • the formula of the morphine sulfate beads to which the sustained-release coating was applied is set forth in Table 1 below:
  • a sustained-release coating was then applied to the morphine sulfate beads.
  • the formula for the sustained release coating of Examples 1 and 2 is set forth in Table 2 below:
  • Example 2 Ingredient (mg) % (mg) % Morphine Base Beads 189.45 mg 86.7% 189.5 mg 83.0% Retardant Coating Eudragit RS 30D 9.5 mg 4.3% 15.2 mg 6.7% Triethyl Citrate 1.9 mg 0.9% 3.0 mg 1.3% Talc 3.8 mg 1.7% 6.1 mg 2.7% Purified Water qs — qs — Overcoat Morphine Sulfate 3.0 mg 1.4% 3.0 mg 1.3% Powder Opadry Red 10.8 mg 5.0% 11.4 mg 5.0% YS-1-1841 Purified Water qs — qs — Total 218.45 mg 100.0% 228.2 mg 100.0%
  • the sustained-release coating was manufactured as follows.
  • the Eudragit RS30D was plasticized with triethyl citrate and talc for approximately 30 minutes.
  • a load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads were coated to a weight gain of 5% and 8% for Examples 1 and 2, respectively.
  • the final protective Opadry dispersion overcoat was then applied in the Wurster Insert.
  • the beads were cured for two days in a dry oven of 45° C. The cured beads were then filled into gelatin capsules at a 30 mg strength.
  • Example 2 1 hour 11.9% 10.2% 2 hours 15.4% 11.3% 4 hours 28.1% 12.8% 8 hours 58.3% 16.4% 12 hours 79.2% 29.6% 18 hours 92.0% 58.1% 24 hours 96.6% 73.2%
  • Example 1 Ten normal, healthy male subjects were enrolled in a four-way, randomized, single-dose, crossover pharmacokinetic/pharmacodynamic study to characterize the effect of food on the pharmacokinetic/pharmacodynamic profile of Example 1 compared with the same product and with morphine CR 30 mg tablet (MS Contin®), each in the fasted state, using plasma morphine concentration and pharmacodynamic parameters. A comparison of Example 2 with morphine controlled release 30 mg tablet (MS Contin®) was also made.
  • Plasma morphine concentrations were used for calculation of pharmacokinetic parameters including: (a) absorption and elimination rates; (b) area under the curve (AUC); (c) maximum plasma concentration (C max ); (d) time to maximum plasma concentration T max ); (e) T 1/2 (elimination).
  • Pharmacodynamic effect compared with plasma concentrations of morphine was to be described from data obtained from the following pharmacodynamic parameters: mood, sedation, respiratory rate, pupillometry and an adjective questionnaire.
  • Blood samples were collected for hematology (hemoglobin, hematocrit, red blood cell count, white blood cell count with differential, platelet count) and blood chemistry analyses (calcium, inorganic phosphate, uric acid, total protein, albumin, cholesterol, alkaline phosphatase, lactate dehydrogenase (LDH), total bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), fasting blood glucose, blood urea nitrogen (BUN), serum creatinine) pre- and post- (72 hours) study (i.e., 72 hours after Phase 4 dose).
  • hemoglobin, hematocrit red blood cell count, white blood cell count with differential, platelet count
  • blood chemistry analyses calcium, inorganic phosphate, uric acid, total protein, albumin, cholesterol, alkaline phosphatase, lactate dehydrogenase (LDH),
  • a urine sample was collected for urinalysis (specific gravity, glucose, albumin, bile, pH, acetone, microscopic examination) pre- and post- (72 hours) study (i.e., 72 hours after Phase 4 dose).
  • a pre-study urinalysis for illicit drugs was performed during the screening process and immediately pre-dose for each administration of the study drug (Day 1 of Phases 1 through 4).
  • Plasma morphine concentrations were determined from blood samples which were drawn just prior to dosing (0 hour) and thereafter at 0.5, 1, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, 12, 18, 24, 36, 48 and 72 hours following each dose.
  • Blood samples each approximately 10 ml, were drawn into tubes containing ethylenediaminetetraacetic acid (EDTA) solution, an anticoagulant. Following centrifugation, the plasma was pipetted into two 5-ml polypropylene, labeled tubes and frozen at ⁇ 20° C. One set of samples was shipped to the designated analytical laboratory in sufficient dry ice to keep them frozen for 2 days, and the second set was retained frozen at the study site as a back-up.
  • EDTA ethylenediaminetetraacetic acid
  • VAS visual analog scale
  • Sedation (measured by VAS on a subject diary sheet)—10 minutes prior to blood sampling.
  • the VAS was anchored on one end as Asleep and the other end as Awake.
  • Respiratory rate (breaths per minute)—within 5 minutes of blood sampling. (Data were recorded on a subject diary sheet.)
  • Pupil size measured by pupillometry—within 5 minutes of blood sampling. Only the left eye was measured at all time periods. (Data were recorded on a subject diary sheet.)
  • FIG. 1 is a graphical representation of the mean sedation vs. time curve for Example 1 (fasted).
  • FIG. 2 is a graphical representation of the mean sedation vs. time curve for Example 2 (fasted).
  • FIG. 3 is a graphical representation of the mean respiratory rate vs. time curve for Example 1 (fasted).
  • FIG. 4 is a graphical representation of the mean respiratory rate vs. time curve for Example 2 (fasted).
  • Plasma morphine concentrations were determined by a high-performance liquid chromatographic procedure. Arithmetic mean Cmax, Tmax, AUC, half-lives calculated from individual plasma morphine concentration-versus-time, and oral bioavailability data were as set forth in Tables 4 and 5 below:
  • Table 6 provides the mean ( ⁇ S.D.) plasma morphine concentrations (ng/ml) following dosing with MS Contin® and Examples 1 and 2.
  • Table 7 provides the mean ( ⁇ S.D.) pharmacokinetic parameters following dosing with MS Contin® And Examples 1-2.
  • Example 1 In comparing Example 1 (fast) to MS Contin® (fast), there was a statistically significant difference in C max . There were no statistically significant differences between the two treatments in T max , AUC (0,72), AUC (O, oo) and T 1/2 (elim) or T 1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • Example 1 In comparing Example 1 (fed) to MS Contin® (fast), there was a statistically significant difference in C max . There were no statistically significant differences between the two treatments in T max , AUC (0,72), AUC (O, oo) and T 1/2 (elim) or T 1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • Example 1 In comparing Example 1 under fed and fasting conditions, there were no statistically significant differences in C max , T max , AUC (0,72), AUC (O, oo) and T 1/2 (elim) or T 1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • Example 1 The effect of food on the absorption of Example 1 is characterized by a greater C max and extended T max and T 1/2 (abs) values.
  • the extent of absorption (based on AUCs), however, is less than 3% different under fed and fasted conditions.
  • Example 1 under fasted or fed conditions nor Example 2 beads are equivalent to MS Contin® tablets.
  • Example 2 beads are equivalent to MS Contin® tablets.
  • both of the experimental controlled-release morphine formulations are bioequivalent to MS Contin® tablets, both provide a relatively lower C max and extended T max and apparent T 1/2 (elim) values.
  • FIG. 5 is a graphical representation of the mean pupil size v. time curve for Example 1 (fasted).
  • FIG. 6 is a graphical representation of the mean pupil size vs. time curve for Example 2 (fasted). No relationship was observed between morphine concentrations and any of the other parameters.
  • Example 1 Two subjects (20%) reported six adverse experiences while receiving MS Contin®. Three subjects (30%) reported six adverse experiences while receiving controlled-release morphine beads (Example 1; fasted). One subject in each of the following treatment groups reported a single adverse experience: Example 1 (fed) and Example 2 (fasted). No clinically significant changes in physical examination or EKG results, clinical laboratory values or vital sign measurements occurred during the study.
  • the questionnaire was a modification of the 22-item questionnaire used by Jasinski, D. R. (1977) Assessment of the Abuse Potential of Morphine-Like Drugs (Methods Used in Man). In Drug Addiction I (Martin, W. R., ed.) pp. 197-258. Springer-Verlag, New York; and Preston, K. L., Jasinski, D. R., and Testa, M. (1991) Abuse Potential and Pharmacological Comparison of Tramadol and Morphine. Drug and Alcohol Dependence 27:7-17.
  • the questionnaire consisted of 10 items to be rated by the subject and observer. The items were related to signs of opiate-agonist drugs and were as follows:
  • FIG. 7 is a graphical representation of the means subject questionnaire vs. time curve for Example 1 (fasted).
  • FIG. 8 is a graphical representation of the means subject questionnaire vs. time curve for Example 2 (fasted).
  • Plasma morphine analyses were conducted using high performance liquid chromatography (HPLC). The limit of quantification was 0.5 ng/mL. Appendix V contains the plasma morphine analytical report.
  • serial plasma morphine values collected from each subject and treatment, were corrected for the zero-hour value by subtraction of the zero-hour value from all subsequent values in that series.
  • FIG. 9 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 1 (fed and fasted) and Example 2 (fasted).
  • Example 1 attains a higher and earlier Cmax but a slightly lower extent of morphine absorption than the formulation of Example 2.
  • Visual examination of the time-action data in respect to sedation, respiratory rate, pupil size, and combined scores from a questionnaire of opioid effects reported by the subjects at serial times following each treatment reveals greater degree of intensity of each pharmacodynamic endpoint during the earlier (e.g., 4-8 hours) portion of the time-action curves.
  • the sustained-release coating comprised an acrylic polymer (i.e., Eudragit® RL).
  • a HPMC protective coat was also included between the Eudragit layer and the morphine immediate release layer to further enhance stability.
  • the formula of the sustained release coating of Example 1 is set forth in Table 9 below:
  • the sustained release and the immediate release coatings were applied as follows.
  • the Eudragit RL 30D was plasticized with triethyl citrate and talc for approximately 30 minutes.
  • a load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 5%.
  • the final protective Opadry dispersion overcoat was then applied in the Wurster Insert.
  • the beads were cured for two days in a dry oven of 45° C.
  • the cured beads were then filled into gelatin capsules at a 30 mg strength.
  • the cured beads were then filled into gelatin capsules at a strength of 30 mg.
  • Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method).
  • the capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated gastric fluid (without enzymes) after the first hour.
  • the results of dissolution testing is set forth in Table 10 below:
  • Plasma morphine concentrations were determined by a high-performance liquid chromatographic procedure. All subjects completed the study and were included in the biopharmaceutical analysis. Arithmetic mean C max , T max , AUC, half-lives calculated from individual plasma morphine concentration-versus-time, and oral bioavailability data are set forth in Tables 11 and 12 below:
  • Table 13 provides the mean ( ⁇ S.D.) plasma morphine concentrations (ng/ml) following dosing with MS Contin® and Example 3.
  • Table 14 provides the mean ( ⁇ S.D.) pharmacokinetic parameters following dosing with MS Contin® And Example 3.
  • the ratios of least-squares mean AUC for the 30 mg capsules of Example 3 given under fed and fasted conditions indicate that AUC values under fed conditions are within ⁇ 20% of those under fasted conditions.
  • the value of C max was 64% greater under fed conditions.
  • the value of T max under fed conditions was approximately 50% of that when given under fasted conditions.
  • the apparent absorption rate was approximately 35% greater under fed conditions, and the apparent elimination rate under fed conditions was approximately 35% of that under fasted conditions, indicating that absorption of morphine is slowed by the presence of food, and elimination rate is increased.
  • the ratios of least-squares mean AUC for the 30 mg capsule of Example 3 and the MS Contin® 30 mg tablet indicate that AUC (0,72) values for Example 3 are within ⁇ 20% of those for MS Contin®, and AUC (0,00) values are 44% greater for Example 3.
  • the value of C max for Example 3 was 29.5% of that for MS Contin®.
  • the value of T max under fed conditions was over five times that for Example 3.
  • the apparent absorption rate was approximately 91% greater for Example 3, and the apparent elimination rate for Example 3 was over 16 times that for MS Contin®, indicating that absorption and elimination of morphine is slower for Example 3.
  • FIG. 10 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 3 (fed and fasted).
  • FIG. 11 is a graphical representation of the mean sedation vs. time curve for Example 3 (fasted).
  • FIG. 12 is a graphical representation of the mean respiratory rate vs. time curve for Example 3 (fasted).
  • FIG. 13 is a graphical representation of the mean pupil size v. time curve for Example 3 (fasted).
  • FIG. 14 is a graphical representation of the mean subject modified specific drug effect questionnaire vs. time curve for Example 2 (fasted).
  • Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor.
  • the formulation of the high load beads is set forth in Table 15 below.
  • the sustained release coating comprised an ethylcellulose acrylic polymer (i.e., Aquacoat ECD 30).
  • a HPMC protective coat was also included after the Aquacoat layer to further enhance stability.
  • the formula of the sustained-release coating of Example 1 is set forth in Table 16 below.
  • the sustained release coating and final overcoat were applied as follows: The combination of Aquacoat ECD 30 and Methocel E5 Premium was plasticized with triethyl citrate for approximately 30 minutes. A load of morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 25%. Upon completion of the Retardant the beads were cured for 3 days in a Temperature/Humidity Chamber of 60° C./80% RH. The cured beads were then dried for 1 day in a dry oven of 60° C.
  • the cured dried beads were charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the final protective Opadry dispersion overcoat was then applied.
  • the finished sustained release beads along with the Low Load Immediate Release Morphine Sulfate beads were individually filled into the same gelatin capsules at a combined strength of 60 mg.
  • the sustained released beads comprised 90% or 54 mg of strength and the Immediate Release Beads comprised 10% or 6 mg of the capsule strength.
  • Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method).
  • the capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour.
  • the results of dissolution testing is set forth in Table 17 below.
  • Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor.
  • the formulation of the high load beads is set forth as per Table 18 in Example 5.
  • the sustained-release coating comprised an acrylic polymer (i.e., Eudragit® RS/RL).
  • a HPMC protective coating was also included after the Eudragit layer to further enhance stability.
  • the formula of the sustained-release coating of Example 5 is set forth in Table 18 below.
  • the sustained-release and the final coatings were applied as follows.
  • the Eudragit RS/RL 30D was plasticized with triethyl citrate and talc for approximately 30 minutes.
  • a load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 5%.
  • the final protective Opadry dispersion overcoat was then applied in the Wurster Insert.
  • the beads were cured for two days in a dry oven of 45° C. The cured beads were then filled into gelatin capsules at a 60 mg strength.
  • Dissolution testing was conducted on the finished products via USP Apparatus II (Paddle Method).
  • the capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour.
  • the results of dissolution testing is set forth in Table 19 below.
  • Matrix Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor.
  • the formulation of the high load matrix beads is set forth in Table 20 below.
  • the matrix component is comprised of an ethylcellulose polymer (i.e., Aquacoat ECD 30).
  • a HPMC protective coat was also included after the aquacoat layer to further enhance stability.
  • the matrix beads were made as follows.
  • the Aquacoat ECD 30 was plasticized with tributyl citrate for approximately 30 minutes. Morphine sulfate powder and lactose were blended for approximately 5 minutes in a hobart mixer.
  • a load of sugar beads was charged into the rotor insert of a Glatt equipped with a 1.2 mm spray nozzle/powder feed assembly.
  • An Accurate Powder Feeder was positioned over the spray nozzle/powder feed assembly and charged with the morphine sulfate/lactose blend.
  • the morphine sulfate/lactose blend is then layered onto the sugar beads using the plasticized hydrophobic polymer dispersion (i.e., Aquacoat ECD 30 and tributyl citrate) as the binding agent.
  • the plasticized hydrophobic polymer dispersion i.e., Aquacoat ECD 30 and tributyl citrate
  • the final protective Opadry dispersion overcoat was then applied.
  • the beads were then cured for one day in a dry oven of 60° C. The cured beads were then filled into gelatin capsules at a 60 mg strength.
  • Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method).
  • the capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour.
  • the results of dissolution testing is set forth in Table 21 below.
  • Hydromorphone beads were prepared by dissolving hydromorphone HC in water, adding Opadry Y-5-1442 and mixing for about 1 hour to obtain a 20% w/w suspension. This suspension was then sprayed onto Nu-Pareil 18/20 mesh beads using a Wurster insert.
  • the loaded hydromorphone beads were then overcoated with a 5% w/w gain of Opadry Light Pink using a Wurster insert. This overcoat was applied as a protective coating.
  • the hydromorphone beads were then coated with a 5% weight gain of a retardant coating mixture of Eudragit RS 30D and Eudragit RL 30D at a ratio of 90:10, RS to RL.
  • a retardant coating mixture of Eudragit RS 30D and Eudragit RL 30D at a ratio of 90:10, RS to RL.
  • Triethyl Citrate (a plasticizer) and Talc (anti-tacking agent) was also included in the Eudragit suspension.
  • the Wurster insert was used to apply the coating suspension.
  • the hydromorphone beads were given a final overcoat of Opadry Light Pink to a 5% weight gain using a Wurster insert. This overcoat was also applied as a protective coating.
  • the hydromorphone beads were cured in a 45° C. oven for 2 days.
  • Beads were hand filled in size #2 clear gelatin capsules at an 8 mg strength of Hydromorphone HCl.
  • Example 7 The formulation for Example 7 is set forth in Table 23 below:

Abstract

Patients are treated with 24-hour oral sustained release opioid formulations which, upon administration, provide an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. These sustained release opioid formulations include an effective amount of at least one retardant material to cause said opioid analgesic to be released at a such a rate as to provide an analgesic effect after oral administration to a human patient for at least about 24 hours, and are characterized by providing an absorption half-life from 1 to about 8 hours. A method of titrating a human patient utilizing these sustained release opioid formulations is also disclosed.

Description

    BACKGROUND OF THE INVENTION
  • The present invention relates to bioavailable sustained-release pharmaceutical formulations of analgesic drugs, in particular opioid analgesics, which provide an extended duration of effect when orally administered.
  • It is the intent of all sustained-release preparations to provide a longer period of pharmacologic response after the administration of the drug than is ordinarily experienced after the administration of the rapid release dosage forms. Such longer periods of response provide for many inherent therapeutic benefits that are not achieved with corresponding short acting, immediate release preparations. This is especially true in the treatment of cancer patients or other patients in need of treatment for the alleviation of moderate to severe pain, where blood levels of an opioid analgesic medicament must be maintained at a therapeutically effective level to provide pain relief. Unless conventional rapid acting drug therapy is carefully administered at frequent intervals to maintain effective steady state blood levels of the drug, peaks and valleys in the blood level of the active drug occur because of the rapid absorption, systemic excretion of the compound and through metabolic inactivation, thereby producing special problems in maintenance of analgesic efficacy.
  • The prior art teaching or the preparation and use of compositions providing the sustained-release of an active compound from a carrier is basically concerned with the release of the active substance into the physiologic fluid of the alimentary tract. However, it is generally recognized that the mete presence of an active substance in the gastrointestinal fluids does not, by itself, insure bioavailability.
  • In order to be absorbed, the active drug substance must be in solution. The dissolution time required for a given proportion of an active substance from a unit dosage form is determined as the proportion of the amount of active drug substance released from a unit dosage form over a specified time base by a test method conducted under standardized conditions. The physiologic fluids of the gastrointestinal tract are the media for determining dissolution time. The present state of the art recognizes many satisfactory test procedures to measure dissolution time for pharmaceutical compositions, and these test procedures are described in official compendia world wide.
  • The primary principle guiding the use of opioid analgesics in the management of chronic pain is the individualization of dosages to meet the different and changing opioid requirements among and within each individual patient. Pain management authorities stress the importance of titration. Titration to the appropriate dose for a particular patient is necessitated by the wide inter-individual differences in the response of different patients to given doses of opioids. While a multitude of factors are responsible for wide inter-individual differences in the response to opioid analgesics, one important factor is rooted in the wide inter-individual variation in metabolism and pharmacokinetics.
  • Those opioids which are most efficiently titrated are those with relatively short elimination half-lives in the range of 3 to 5 hours (e.g., morphine, hydromorphone, oxycodone) as compared to long (12 to 72 hours) and more variable half-life analgesics (e.g., methadone, levorphanol). The shorter half life drugs approach steady-state concentrations in approximately a day rather than in several days to a week or more. Only at steady-state can one expect that the balance between efficacy and side effects will persist at a given dosing schedule. Having confidence that the patient is at approximate steady-state a day or so following initiation of dosing allows for much quicker assessment of whether the dosage is appropriate for that individual.
  • Once-a-day orally administrable dosage forms have previously been developed in the art and are commercially available. Presently, however, there are no commercially available sustained-release 24-hour opioid analgesic preparations; however, experience with the 12-hour sustained release preparations have led to a general understanding in the medical community that in order to titrate a patient who is to receive opioid analgesic therapy it is necessary to use an immediate release opioid analgesic dosage form, such as a parenteral formulation, an immediate release solution or tablet, or the like. Only after a suitable steady-state level is achieved in the patient by using immediate release opioid preparations may a patient be switched to a sustained release oral opioid formulation.
  • It therefore follows that it would be very desirable for practitioners to have available a sustained-release opioid analgesic preparation which provides appropriate pharmacokinetic parameters (e.g., absorption profile) and accompanying pharmacodynamic response in the patient (e.g., relief from pain) such that the same dosage form may be used to both titrate a patient receiving opioid analgesic therapy and used in chronic maintenance therapy after titration of the patient. This would eliminate the need to first titrate a patient on an immediate release opioid dosage form before switching the patient to a sustained-release dosage form for chronic therapy as described above. Preferably the sustained-release preparations will provide a duration of effect lasting longer than about twelve hours such that a drug that may be administered to a patient only once a day. Preferably, the sustained release dosage form will not only provide effective pain relief for a duration of greater than about 12 hours, but will additionally provide a pharmacokinetic and pharmacodynamic profile which will allow a patient who is to receive opioid analgesic therapy to be titrated and chronically treated with the same sustained-release dosage form.
  • Many of the oral opioid analgesic formulations that are currently available in the market must be administered every four to six hours daily; a selected few are formulated for less frequent 12 hour dosing.
  • There is also a need to develop a drug formulation which provides an absorption profile which is suitable for both titrating a patient who is receiving opioid analgesic therapy and which also provides sustained release of an opioid analgesic sufficient to provide analgesia for at least about 12 hours duration. This would eliminate the need to first titrate a patient with immediate release dosage forms (e.g. parenteral, oral, rectal) of opioid analgesic and then switch the patient to a sustained release form of the opioid analgesic.
  • Morphine, which is considered to be the prototypic opioid analgesic, has been formulated into twice-daily controlled-release formulations (i.e., MS Contin® tablets, commercially available from Purdue Frederick Company; and Kapanol®, commercially available from F.H. Faulding and Company; and Oramorph® SR, previously referred to as Roxanol® SR, commercially available from Roxane).
  • An orally administrable opioid formulation which would provide an extended duration of analgesia without higher incidence of adverse effects would be highly desirable. Such an oral sustained-release formulation of an opioid analgesic would be bioavailable and provide effective steady-state blood levels (e.g., plasma levels) of the drug when orally administered such that a duration of analgesic efficacy about 24 hours or more is obtained.
  • OBJECTS AND SUMMARY OF THE INVENTION
  • It is accordingly an object of the present invention to provide a method for treating patients in moderate to severe pain with an orally administered pharmaceutical dosage form of an opioid analgesic that is suitable for once-a-day administration.
  • It is yet another object of the present invention to provide a method for treating patients with a once-a-day opioid analgesic formulation which provides greater analgesic efficacy than that which is obtainable with the preferred Q12H (every 12 hour) analgesic therapies.
  • It is further an object of the present invention to provide an opioid analgesic dosage form which provides sustained-release of the opioid and is also capable for use in titrating a patient receiving opioid analgesic therapy.
  • In accordance with the above objects and others, the present invention is related in part to the surprising discovery that in order to provide a 24 hour dosage form of an opioid analgesic, it is critical to formulate a sustained release formulation in pain with an analgesic preparation which provides an initially rapid opioid release so that the minimum effective analgesic concentration can be quickly approached in many patients who have measurable if not significant pain at the time of dosing. Due to the unique release profile of the dosage form of the invention, it is possible to use a single dosage form according to the present invention to titrate a patient receiving opioid analgesic therapy while providing sustained-release of an opioid analgesic to once-a-day sustained release oral dosage opioid formulations which comprise an opioid analgesic and an effective amount of at least one retardant material to cause the opioid analgesic to be released at an effective rate to provide an analgesic effect after oral administration to a human patient for at least about 24 hours.
  • The inventive formulations, when administered in humans, provide an initially rapid rate of rise in the plasma concentration of the opioid characterized by providing an absorption half-life from 1.5 to about 8 hours. In preferred embodiments, the inventive once-daily oral sustained release formulations provides an absorption half-life from 2 to about 4 hours.
  • The present invention is also directed to a method for titrating human patients with a sustained release oral opioid formulation. The first step of this method comprises administering to a human patient on a once-a-day basis a unit dose of the inventive once-a-day oral sustained release opioid formulations described above and in the following paragraphs. Thereafter, the method includes the further step of monitoring pharmacokinetic and pharmacodynamic parameters elicited by said formulation in said human patient and determining whether said pharmacokinetic and/or pharmacodynamic parameters are appropriate to treat said patient on a repeated basis. The patient is titrated by adjusting the dose of said opioid analgesic administered to the patient by administering a unit dose of said sustained release opioid analgesic formulation containing a different amount of opioid analgesic if it is determined that said pharmacokinetic and/or said pharmacodynamic parameters are not satisfactory or maintaining the dose of said opioid analgesic in the unit dose at a previously administered amount if said pharmacokinetic and/or pharmacodynamic parameters are deemed appropriate. The titration is continued by further adjusting the dose of the opioid analgesic until appropriate steady-state pharmacokinetic/pharmacodynamic parameters are achieved in the patient. Thereafter, the administration of the dose of the opioid analgesic in the oral sustained release formulation is continued on a once-a-day basis until treatment is terminated.
  • The term “bioavailability” is defined for purposes of the present invention as the extent to which the drug (e.g., opioid analgesic) is absorbed from the unit dosage forms.
  • The term “sustained release” is defined for purposes of the present invention as the release of the drug (e.g., opioid analgesic) at such a rate that blood (e.g., plasma) levels are maintained within the therapeutic range but below toxic levels over a period of time of about 24 hours or longer.
  • The phrase “rapid rate of rise” with regard to opioid plasma concentration is defined for purposes of the present invention as signifying that the formulation provides a T1/2 (abs), or half-life of absorption, from 1.5 about hours to about 8 hours.
  • The term T1/2 (abs) is defined for purposes of the present invention as the amount of time necessary for one-half of the absorbable dose of opioid to be transferred to plasma. This value is calculated as a “true” value (which would take into account the effect of elimination processes), rather than an “apparent” absorption half-life.
  • The term “steady state” means that a plasma level for a given drug has been achieved and which is maintained with subsequent doses of the drug at a level which is at or above the minimum effective therapeutic level and is below the minimum toxic plasma level for a given drug. For opioid analgesics, the minimum effective therapeutic level will be a partially determined by the amount of pain relief achieved in a given patient. It will be well understood by those skilled in the medical art that pain measurement is highly subjective and great individual variations may occur among patients.
  • The terms “maintenance therapy” and “chronic therapy” are defined for purposes of the present invention as the drug therapy administered to a patient after a patient is titrated with an opioid analgesic to a steady state as defined above.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The following drawings are illustrative of embodiments of the invention and are not meant to limit the scope of the invention as encompassed by the claims.
  • FIG. 1 is a graphical representation of the mean sedation vs. time curve for Example 1 (fasted);
  • FIG. 2 is a graphical representation of the mean sedation vs. time curve for Example 2 (fasted);
  • FIG. 3 is a graphical representation of the mean respiratory rate vs. time curve for Example 1 (fasted);
  • FIG. 4 is a graphical representation of the mean respiratory rate vs. time curve for Example 2 (fasted);
  • FIG. 5 is a graphical representation of the mean pupil size v. time curve for Example 1 (fasted);
  • FIG. 6 is a graphical representation of the mean pupil size vs. time curve for Example 2 (fasted);
  • FIG. 7 is a graphical representation of the means subject questionnaire vs. time curve for Example 1 (fasted);
  • FIG. 8 is a graphical representation of the means subject questionnaire vs. time curve for Example 2 (fasted);
  • FIG. 9 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 1 (fed and fasted) and Example 2 (fasted);
  • FIG. 10 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 3 (fed and fasted);
  • FIG. 11 is a graphical representation of the mean sedation vs. time curve for Example 3 (fasted);
  • FIG. 12 is a graphical representation of the mean respiratory rate vs. time curve for Example 3 (fasted);
  • FIG. 13 is a graphical representation of the mean pupil size v. time curve for Example 3 (fasted); and
  • FIG. 14 is a graphical representation of the mean subject modified specific drug effect questionnaire vs. time curve for Example 2 (fasted).
  • DETAILED DESCRIPTION
  • Even at steady-state dosages of opioid analgesics, most patients remain in measurable or significant pain. The state-of-the-art approach to controlled release opioid therapy is to provide formulations which exhibit zero order pharmacokinetics and have minimal peak to trough fluctuation in opioid levels with repeated dosing. This zero order release provides very slow opioid absorption, and a generally flat serum concentration curve over time. A flat serum concentration curve is generally considered to be advantageous because it would in effect mimic a steady-state level where efficacy is provided but side effects common to opioid analgesics are minimized. However, by formulating sustained release opioids in this manner, it has been discovered that the patients often experience considerable discomfort at about the time the next oral dose of the opioid is administered.
  • It has now been surprisingly discovered that quicker and greater analgesic efficacy is achieved by 24 hour oral opioid formulations which do not exhibit a substantially flat serum concentration curve, but which instead provide a more rapid initial opioid release so that the minimum effective analgesic concentration can be more quickly approached in many patients who have measurable if not significant pain at the time of dosing. Even at steady-state dosages of oral opioid analgesics, most patients have been found to remain in measurable or significant pain and would benefit greatly from treatment with the novel approach to oral opioid treatment disclosed herein. Also surprising and unexpected is the fact that while the methods of the present invention achieve quicker and greater analgesic efficacy, there is not a significantly greater incidence in side effects which would normally be expected as higher peak plasma concentrations occur.
  • Defining effective analgesic plasma opioid (e.g., morphine) levels is very complex. However, there is generally a “minimally effective analgesic concentration” (MEAC) in plasma for a particular opioid below which no analgesia is provided. While there is an indirect relationship between, e.g., plasma morphine levels and analgesia, higher plasma levels are generally associated with superior pain relief. There is a lag time or hysteresis, between the time of peak plasma opioid levels and the time of peak drug effects. This holds true for the treatment of pain with opioid analgesics in general.
  • The inventive sustained release once-a-day formulations may be characterized by the fact that they are designed to provide an initially rapid rate of rise in the plasma concentration of said opioid characterized by providing an absorption half-life from about 1 to about 8 hours, when the oral sustained release formulation is administered in the fasted state (i.e., without food). In certain embodiments, the absorption half-life is preferably from about 1 to about 6 hours, and more preferably from about 1 to about 3 hours.
  • The inventive formulations may be further characterized by having a surprisingly fast time to peak drug plasma concentration (i.e., tmax). The tmax of the sustained release formulations of the present invention may be from about 2 to about 10 hours. In certain preferred embodiments, the tmax provided by these formulations may be from about 4 to about 9 hours.
  • The administration of 24-hour opioid oral sustained release formulations in accordance with the present invention reveals a greater degree of intensity of certain pharmacodynamic endpoints during the earlier portions of the plasma concentration curve (e.g., 4-8 hours after oral administration), such as sedation respiratory rate, pupil size, and/or combined scores from a questionnaire of opioid effects reported by the subjects at serial times following each treatment (i.e., administration of the oral dosage form). Other measures of analgesic efficacy such as sum of pain intensity difference (SPID) and total pain relief (TOTPAR) have consistently higher numerical scores via the presently claimed methods, while also generating in many cases fewer adverse events (which in general are predominantly mild or moderate somnolence, nausea and/or dizziness).
  • Opioid analgesic compounds which may be used in the present invention include alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, cyclazocine, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levallorphan, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, propheptazine, promedol, properidine, propiram, propoxyphene, sufentanil, tramadol, tilidine, salts thereof, mixtures of any of the foregoing, mixed mu-agonists/antagonists, mu-antagonist combinations, and the like. The opioid analgesic may be in the form of the free base, a salt, a complex, etc. In certain preferred embodiments, the opioid analgesic is selected from the group consisting of hydromorphone, oxycodone, dihydrocodeine, codeine, dihydromorphine, morphine, buprenorphine, salts of any of the foregoing, and mixtures of any of the foregoing.
  • In one preferred embodiment the sustained-release opioid oral dosage form of the present invention includes hydromorphone as the therapeutically active ingredient in an amount from about 4 to about 64 mg hydromorphone hydrochloride. In another preferred embodiment, the opioid analgesic comprises morphine, and the sustained release oral dosage forms of the present invention include form about 5 mg to about 800 mg morphine, by weight. Alternatively, the dosage form may contain molar equivalent amounts of other hydromorphone or morphine salts or of the base. In certain preferred embodiments wherein the opioid is morphine, the maximum plasma concentration is from about 2 ng/ml to about 14 ng/ml, and preferably is from about 3 ng/ml to about 8 ng/ml, based on a 30 mg dose of morphine sulfate. In another preferred embodiment, the opioid analgesic comprises oxycodone, the sustained release oral dosage forms of the present invention include from about 5 mg to about 400 mg oxycodone. In other preferred embodiments, the dosage form contains an appropriate amount of another of the opioid analgesics to provide a substantially equivalent therapeutic effect.
  • The sustained release dosage forms of the present invention generally achieve and maintain therapeutic levels substantially without significant increases in the intensity and/or degree of concurrent side effects, such as nausea, vomiting or drowsiness, which are often associated with high blood levels of opioid analgesics. There is also evidence to suggest that the use of the present dosage forms leads to a reduced risk of drug addiction. Furthermore, the sustained release dosage forms of the present invention preferably releases the opioid analgesic at a rate that is independent of pH, e.g., between pH 1.6 and 7.2. In other words, the dosage forms of the present invention avoid “dose dumping” upon oral administration.
  • In the present invention, the oral opioid analgesics have been formulated to provide for an increased duration of analgesic action allowing once-daily dosing. Surprisingly, these formulations, at comparable daily dosages of conventional immediate release drug, are associated with a lower incidence in severity of adverse drug reactions and can also be administered at a lower daily dose than conventional oral medication while maintaining pain control.
  • The retardant material utilized in the sustained release formulations of the invention may be one which is known in the art, including but not limited to acrylic polymers, alkylcelluloses, shellac, zein, hydrogenated vegetable oil, hydrogenated castor oil, and mixtures of any of the foregoing.
  • In certain preferred embodiments of the present invention, the sustained release opioid dosage forms comprise a plurality of substrates comprising the active ingredient, which substrates are coated with a sustained release coating comprising a retardant material. The coating formulations of the present invention should be capable of producing a strong, continuous film that is smooth and elegant, capable of supporting pigments and other coating additives, non-toxic, inert, and tack-free.
  • The sustained release preparations of the present invention may be used in conjunction with any multiparticulate system, such as beads, spheroids, microspheres, seeds, pellets, ion-exchange resin beads, and other multi-particulate systems in order to obtain a desired sustained release of the therapeutically active agent. Beads, granules, spheroids, or pellets, etc., prepared in accordance with the present invention can be presented in a capsule or in any other suitable unit dosage form.
  • When the substrates of the present invention are inert pharmaceutical beads, the inert pharmaceutical beads may be from about 8 mesh to about 50 mesh. In certain preferred embodiments, the beads are, e.g., nu pariel 18/20 beads.
  • In certain preferred embodiments of the present invention, the sustained release opioid dosage forms comprise a plurality of substrates comprising the active ingredient, which substrates are coated with a sustained release coating. The coating formulations of the present invention should be capable of producing a strong, continuous film that is smooth and elegant, capable of supporting pigments and other coating additives, non-toxic, inert, and tack-free.
  • In order to obtain a sustained release of the opioid sufficient to provide an analgesic effect for the extended durations set forth in the present invention, the substrate comprising the therapeutically active agent may be coated with a sufficient amount of hydrophobic material to obtain a weight gain level from about 2 to about 30 percent, although the overcoat may be greater depending upon the physical properties of the particular opioid analgesic compound utilized and the desired release rate, among other things.
  • In order to obtain a sustained release of the opioid sufficient to provide an analgesic effect for the extended durations set forth in the present invention, the substrate comprising the therapeutically active agent may be coated with a sufficient amount of retardant material to obtain a weight gain level from about 2 to about 30 percent, although the overcoat may be greater depending upon the physical properties of the particular opioid analgesic compound utilized and the desired release rate, among other things.
  • The solvent which is used for the retardant material, which is typically hydrophobic, may be any pharmaceutically acceptable solvent, including water, methanol, ethanol, methylene chloride and mixtures thereof. It is preferable however, that the coatings be based upon aqueous dispersions of the hydrophobic material.
  • In certain preferred embodiments of the present invention, the hydrophobic polymer comprising the sustained release coating is a pharmaceutically acceptable acrylic polymer, including but not limited to acrylic acid and methacrylic acid copolymers, methyl methacrylate copolymers, ethoxyethyl methacrylates, cyanoethyl methacrylate, aminoalkyl methacrylate copolymer, poly(acrylic acid), poly(methacrylic acid), methacrylic acid alkylamide copolymer, poly(methyl methacrylate), poly(methacrylic acid anhydride), methyl methacrylate, polymethacrylate, poly(methyl methacrylate) copolymer, polyacrylamide, aminoalkyl methacrylate copolymer and glycidyl methacrylate copolymers.
  • In certain preferred embodiments, the acrylic polymer is comprised of one or more ammonio methacrylate copolymers. Ammonio methacrylate copolymers are well known in the art, and are described in NF XVII as fully polymerized copolymers of acrylic and methacrylic acid esters with a low content of quaternary ammonium groups.
  • In one preferred embodiment, the acrylic coating is an acrylic resin lacquer used in the form of an aqueous dispersion, such as that which is commercially available from Rohm Pharma under the Tradename Eudragit®. In further preferred embodiments, the acrylic coating comprises a mixture of two acrylic resin lacquers commercially available from Rohm Pharma under the Tradenames Eudragit® RL 30 D and Eudragit® RS 30 D, respectively. Eudragit® RL 30 D and Eudragit® RS 30 D are copolymers of acrylic and methacrylic esters with a low content of quaternary ammonium groups, the molar ratio of ammonium groups to the remaining neutral (meth)acrylic esters being 1:20 in Eudragit® RL 30 D and 1:40 in Eudragit® RS 30 D. The mean molecular weight is about 150,000. The code designations RL (high permeability) and RS (low permeability) refer to the permeability properties of these agents. Eudragit® RL/RS mixtures are insoluble in water and in digestive fluids. However, coatings formed from the same are swellable and permeable in aqueous solutions and digestive fluids.
  • The Eudragit® RL/RS dispersions of the present invention may be mixed together in any desired ratio in order to ultimately obtain a sustained release formulation having a desirable dissolution profile. Desirable sustained release formulations may be obtained, for instance, from a retardant coating derived from 100% Eudragit® RL, 50% Eudragit® RL and 50% Eudragit® RS, and 10% Eudragit® RL:Eudragit® 90% RS. Of course, one skilled in the art will recognize that other acrylic polymers may also be used, such as, for example, Eudragit® L.
  • In other preferred embodiments, the hydrophobic polymer which may be used for coating the substrates of the present invention is a hydrophobic alkyl cellulosic material such as ethylcellulose. Those skilled in the art will appreciate that other cellulosic polymers, including other alkyl cellulosic polymers, may be substituted for part or all of the ethylcellulose included in the hydrophobic polymer coatings of the present invention.
  • One commercially available aqueous dispersion of ethylcellulose is Aquacoat® (FMC Corp., Philadelphia, Pa., U.S.A.). Aquacoat® is prepared by dissolving the ethylcellulose in a water-immiscible organic solvent and then emulsifying the same in water in the presence of a surfactant and a stabilizer. After homogenization to generate submicron droplets, the organic solvent is evaporated under vacuum to form a pseudolatex. The plasticizer is not incorporated in the pseudolatex during the manufacturing phase. Thus, prior to using the same as a coating, it is necessary to intimately mix the Aquacoat® with a suitable plasticizer prior to use.
  • Another aqueous dispersion of ethylcellulose is commercially available as Surelease® (Colorcon, Inc., West Point, Pa., U.S.A.). This product is prepared by incorporating plasticizer into the dispersion during the manufacturing process. A hot melt of a polymer, plasticizer (dibutyl sebacate), and stabilizer (oleic acid) is prepared as a homogeneous mixture, which is then diluted with an alkaline solution to obtain an aqueous dispersion which can be applied directly onto substrates.
  • In embodiments of the present invention where the coating comprises an aqueous dispersion of a hydrophobic polymer, the inclusion of an effective amount of a plasticizer in the aqueous dispersion of hydrophobic polymer will further improve the physical properties of the film. For example, because ethylcellulose has a relatively high glass transition temperature and does not form flexible films under normal coating conditions, it is necessary to plasticize the ethylcellulose before using the same as a coating material. Generally, the amount of plasticizer included in a coating solution is based on the concentration of the film-former, e.g., most often from about 1 to about 50 percent by weight of the film-former. Concentration of the plasticizer, however, can only be properly determined after careful experimentation with the particular coating solution and method of application.
  • Examples of suitable plasticizers for ethylcellulose include water insoluble plasticizers such as dibutyl sebacate, diethyl phthalate, triethyl citrate, tributyl citrate, and triacetin, although it is possible that other water-insoluble plasticizers (such as acetylated monoglycerides, phthalate esters, castor oil, etc.) may be used. Triethyl citrate is especially preferred.
  • Examples of suitable plasticizers for the acrylic polymers of the present invention include citric acid esters such as triethyl citrate NF XVI, tributyl citrate, dibutyl phthalate, and possibly 1,2-propylene glycol, polyethylene glycols, propylene glycol, diethyl phthalate, castor oil, and triacetin, although it is possible that other water-insoluble plasticizers (such as acetylated monoglycerides, phthalate esters, castor oil, etc.) may be used. Triethyl citrate is especially preferred.
  • The sustained release profile of the formulations of the invention can be altered, for example, by varying the thickness of the hydrophobic coating, changing the particular hydrophobic material used, or altering the relative amounts of, e.g., different acrylic resin lacquers, altering the manner in which the plasticizer is added (e.g., when the sustained release coating is derived from an aqueous dispersion of hydrophobic polymer), by varying the amount of plasticizer relative to hydrophobic polymer, by the inclusion of additional ingredients or excipients, by altering the method of manufacture, etc.
  • Sustained release spheroids or beads, coated with an opioid may be prepared, e.g. by dissolving the opioid analgesic in water and then spraying the solution onto a substrate, for example, nu pariel 18/20 beads, using a Wurster insert. Optionally, additional ingredients are also added prior to coating the beads in order to assist the opioid binding to the substrates, and/or to color the solution, etc. For example, a product which includes hydroxypropyl methylcellulose, etc. with or without colorant may be added to the solution and the solution mixed (e.g., for about 1 hour) prior to application of the same onto the beads. The resultant coated substrate, in this example beads, may then be optionally overcoated with a barrier agent, to separate the therapeutically active agent from the hydrophobic sustained release coating. An example of a suitable barrier agent is one which comprises hydroxypropyl methylcellulose. However, any film-former known in the art may be used. It is preferred that the barrier agent does not affect the dissolution rate of the final product.
  • The opioid, HPMC protected (optional) beads may then be overcoated with hydrophobic polymer, preferably with an effective amount of plasticizer.
  • The coating solutions of the present invention preferably contain, in addition to the film-former, plasticizer, and solvent system (i.e., water), a colorant to provide elegance and product distinction. Color may be added to the solution of the therapeutically active agent instead, or in addition to the aqueous dispersion of hydrophobic polymer.
  • The plasticized aqueous dispersion of hydrophobic polymer may be applied onto the substrate comprising the therapeutically active agent by spraying using any suitable spray equipment known in the art. In a preferred method, a Wurster fluidized-bed system is used in which an air jet, injected from underneath, fluidizes the core material and effects drying while the acrylic polymer coating is sprayed on. A sufficient amount of the aqueous dispersion of hydrophobic polymer to obtain a predetermined sustained-release of said therapeutically active agent when said coated substrate is exposed to aqueous solutions, e.g. gastric fluid, is preferably applied, taking into account the physically characteristics of the therapeutically active agent, the manner of incorporation of the plasticizer, etc. After coating with the hydrophobic polymer, a further overcoat of a film-former, such as Opadry®, is optionally applied to the beads. This overcoat is provided, if at all, in order to substantially reduce agglomeration of the beads.
  • Next, the coated beads are cured in order to obtain a stabilized release rate of the therapeutically active agent.
  • When the coating comprises an aqueous dispersion of ethylcellulose, the coated substrate is preferably subjected to curing at a temperature greater than the glass transition temperature of the coating solution (i.e., ethylcellulose) and at a relative humidity from about 60% to about 100%, until the curing endpoint is reached, e.g., about 60° C. and a relative humidity from about 60% to about 100% for a time period from about 48 to about 72 hours, as described in U.S. Pat. No. 5,273,760, hereby incorporated by reference.
  • In preferred embodiments of the present invention directed to the acrylic coating, a stabilized product is obtained by subjecting the coated substrate to oven curing at a temperature above the Tg of the plasticized acrylic polymer for the required time period, the optimum values for temperature and time for the particular formulation being determined experimentally. In certain embodiments of the present invention, the stabilized product is obtained via an oven curing conducted at a temperature of about 45° C. for a time period from about 24 to about 48 hours or longer, as described in U.S. Pat. No. 5,286,493, hereby incorporated by reference.
  • The release of the therapeutically active agent from the sustained-release formulation of the present invention can be further influenced, i.e., adjusted to a desired rate, by the addition of one or more release-modifying agents, or by providing one or more passageways through the coating. The ratio of hydrophobic polymer to water soluble material is determined by, among other factors, the release rate required and the solubility characteristics of the materials selected.
  • The release-modifying agents which function as pore-formers may be organic or inorganic, and include materials that can be dissolved, extracted or leached from the coating in the environment of use. The pore-formers may comprise one or more hydrophilic polymers such as hydroxypropylmethylcellulose. The sustained release coatings of the present invention can also include erosion-promoting agents such as starch and gums. The sustained release coatings of the present invention can also include materials useful for making microporous lamina in the environment of use, such as polycarbonates comprised of linear polyesters of carbonic acid in which carbonate groups reoccur in the polymer chain. The release-modifying agent may also comprise a semi-permeable polymer. In certain preferred embodiments, the release-modifying agent is selected from hydroxypropylmethylcellulose, lactose, metal stearates, and mixtures of any of the foregoing. The sustained release coatings of the present invention may also include an exit means comprising at least one passageway, orifice, or the like. The passageway may be formed by such methods as those disclosed in U.S. Pat. Nos. 3,845,770; 3,916,889; 4,063,064; and 4,088,864 (all of which are hereby incorporated by reference). The passageway can have any shape such as round, triangular, square, elliptical, irregular, etc.
  • In other embodiments of the present invention, the present invention may utilize a multiparticulate sustained release matrix. Suitable materials for inclusion in a sustained release matrix are
  • (a) Hydrophilic polymers, such as gums, cellulose ethers, acrylic resins and protein derived materials. Of these polymers, the cellulose ethers, especially hydroxyalkylcelluloses and carboxyalkylcelluloses, are preferred. The oral dosage form may contain between 1% and 80% (by weight) of at least one hydrophilic or hydrophobic polymer.
  • (b) Digestible, long chain (C8C50, especially C12-C40), substituted or unsubstituted hydrocarbons, such as fatty acids, fatty alcohols, glyceryl esters of fatty acids, mineral and vegetable oils and waxes. Hydrocarbons having a melting point of between 25° and 90° C. are preferred. Of these long chain hydrocarbon materials, fatty (aliphatic) alcohols are preferred. The oral dosage form may contain up to 60% (by weight) of at least one digestible, long chain hydrocarbon.
  • (c) Polyalkylene glycols. The oral dosage form may contain up to 60% (by weight) of at least one polyalkylene glycol.
  • For example, a suitable matrix may be one which comprises at least one water soluble hydroxyalkyl cellulose, at least one C12-C36, preferably C14-C22, aliphatic alcohol and, optionally, at least one polyalkylene glycol. The at least one hydroxyalkyl cellulose is preferably a hydroxy (C1 to C6) alkyl cellulose, such as hydroxypropylcellulose, hydroxypropylmethylcellulose and, especially, hydroxyethyl cellulose. The amount of the at least one hydroxyalkyl cellulose in the present oral dosage form will be determined, inter alia, by the precise rate of opioid release required. The at least one aliphatic alcohol may be, for example, lauryl alcohol, myristyl alcohol or stearyl alcohol. In certain preferred embodiments, the at least one aliphatic alcohol is cetyl alcohol or cetostearyl alcohol. The amount of the at least one aliphatic alcohol in the present oral dosage form will be determined, as above, by the precise rate of opioid release required. It will also depend on whether at least one polyalkylene glycol is present in or absent from the oral dosage form. In the absence of at least one polyalkylene glycol, the oral dosage form preferably contains between 20% and 50% (by wt) of the at least one aliphatic alcohol. When at least one polyalkylene glycol is present in the oral dosage form, then the combined weight of the at least one aliphatic alcohol and the at least one polyalkylene glycol preferably constitutes between 20% and 50% (by wt) of the total dosage.
  • In one embodiment, the ratio of, e.g., at least one hydroxyalkyl cellulose or acrylic resin to at least one aliphatic alcohol/polyalkylene glycol determines, to a considerable extent, the release rate of the opioid from the formulation. A ratio of the at least one hydroxyalkyl cellulose to at least one aliphatic alcohol/polyalkylene glycol of between 1:2 and 1:4 is preferred, with a ratio of between 1:3 and 1:4 being particularly preferred.
  • At least one polyalkylene glycol may be, for example, polypropylene glycol or, preferably, polyethylene glycol. The number average molecular weight of the at least one polyalkylene glycol is preferred between 1000 and 15000 especially between 1500 and 12000.
  • Another suitable sustained release matrix would comprise an alkylcellulose (especially ethyl cellulose), a C12 to C36 aliphatic alcohol and, optionally, a polyalkylene glycol.
  • In addition to the above ingredients, a sustained release matrix may also contain suitable quantities of other materials, e.g., diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art.
  • These sustained release matrices may be prepared, for example, by
  • (a) forming granules comprising at least one water soluble hydroxyalkyl cellulose and opioid or an opioid salt,
  • (b) mixing the hydroxyalkyl cellulose containing granules with at least one C12-C36 aliphatic alcohol, and
  • (c) optionally, compressing and shaping the granules. Preferably, the granules are formed by wet granulating the hydroxyalkyl cellulose/opioid with water. The amount of water added during the wet granulation step may be, e.g., between 1.5 and 5 times, especially between 1.75 and 3.5 times, the dry weight of the opioid.
  • In yet other alternative embodiments, a spheronizing agent, together with the active ingredient can be spheronized to form spheroids. Microcrystalline cellulose is preferred, although hydrous lactose impalpable is preferably utilized for morphine sulfate sustained release formulations prepared by powder-layering techniques. A suitable microcrystalline cellulose is, for example, the material sold as Avicel PH 101 (Trade Mark, FMC Corporation). In such embodiments, in addition to the active ingredient and spheronizing agent, the spheroids may also contain a binder. Suitable binders, such as low viscosity, water soluble polymers, will be well known to those skilled in the pharmaceutical art. However, water soluble hydroxy lower alkyl cellulose, such as hydroxy propyl cellulose, are preferred. Additionally (or alternatively) the spheroids may contain a water insoluble polymer, especially an acrylic polymer, an acrylic copolymer, such as a methacrylic acid-ethyl acrylate copolymer, or ethyl cellulose. In such embodiments, the sustained release coating will generally include a water insoluble material such as (a) a wax, either alone or in admixture with a fatty alcohol; or (b) shellac or zein.
  • The substrates of the present invention may also be prepared via a melt pellitization technique. In such circumstance, the opioid in finely divided form is combined with a binder (also in particulate form) and other optional inert ingredients, and thereafter the mixture is pelletized, e.g., by mechanically working the mixture in a high shear mixer to form the pellets (granules, spheres). Thereafter, the pellets (granules, spheres) may be sieved in order to obtain pellets of the requisite size. The binder material is preferably in particulate form and has a melting point above about 40° C. Suitable binder substances include, for example, hydrogenated castor oil, hydrogenated vegetable oil, other hydrogenated fats, fatty alcohols, fatty acid esters, fatty acid glycerides, and the like.
  • In certain preferred embodiments of the present invention, an effective amount of opioid in immediate release form is included in the 24 hour sustained release unit dose opioid formulation to be administered. The immediate release form of the opioid is included in an amount which is effective to shorten the time to maximum concentration of the opioid in the blood (e.g., plasma). In such embodiments, an effective amount of the opioid in immediate release form may be coated onto the substrates of the present invention. For example, where the extended release opioid from the formulation is due to a controlled release coating, the immediate release layer would be overcoated on top of the controlled release coating. On the other hand, the immediate release layer may be coated onto the surface of substrates wherein the opioid is incorporated in a controlled release matrix. Where a plurality of the sustained release substrates comprising an effective unit dose of the opioid (e.g., multiparticulate systems including pellets, spheres, beads and the like) are incorporated into a hard gelatin capsule, the immediate release portion of the opioid dose may be incorporated into the gelatin capsule via inclusion of the sufficient amount of immediate release opioid as a powder or granulate within the capsule. Alternatively, the gelatin capsule itself may be coated with an immediate release layer of the opioid. One skilled in the art would recognize still other alternative manners of incorporating the immediate release opioid portion into the unit dose. Such alternatives are deemed to be encompassed by the appended claims. It has been discovered that by including such an effective amount of immediate release opioid in the unit dose, the experience of relatively higher levels of pain in patients is significantly reduced.
  • The dosage form may be provided by preparing a dosage form consistent with one of the above described methods or by other means known to those skilled in the pharmaceutical art.
  • In addition to the above, the sustained release opioid formulations may also be manufactured as tablets. In such instances, the tablet may contain, in addition to the opioid and the retardant material, suitable quantities of other materials, e.g. diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art in amounts up to about 50% by weight of the particulate if desired. Specific examples of pharmaceutically acceptable carriers and excipients that may be used to formulate oral dosage forms are described in the Handbook of Pharmaceutical Excipients, American Pharmaceutical Association (1986), incorporated by reference herein. Techniques and compositions for making solid oral dosage forms are described in Pharmaceutical Dosage Forms: Tablets (Lieberman, Lachman and Schwartz, editors) Second Edition, published by Marcel Dekker, Inc., incorporated by reference herein. Techniques and compositions for making tablets (compressed and molded), capsules (hard and soft gelatin) and pills are also described in Remington's Pharmaceutical Sciences, (Arthur Osol, editor), 1553-1593 (1980), incorporated by reference herein.
  • In order to titrate a human patient with the inventive sustained release opioid formulations, a plurality of blood samples are taken from the patient over the course of the dosing interval. The samples thus obtained are then tested to determine the plasma level of the opioid analgesic, and any active metabolites thereof. The values thus obtained may then be utilized to determine additional pharmacokinetic parameters. A determination as to whether the patient has obtained an adequate pharmacodynamic response with said dosage form will be made, e.g., reference to predetermined blood levels, comparison of the results subjective pain tests given to the patient, the adverse effect profile of the drug in the patient, or the like. A determination may then be made as to whether an upward or downward adjustment of the dose is necessary.
  • The administration of the sustained release unit dosage form is continued over the dosing interval of the unit dose to maintain an adequate pharmacodynamic response with the sustained release dosage form. Preferably the adequate pharmacodynamic response will last between about 12 and about 24 hours, most preferably about 24 hours or greater.
  • The administration of the sustained release unit dosage form is continued over the dosing interval of the unit dose to maintain said adequate pharmacodynamic response with said sustained release dosage form.
  • If necessary, the above steps are repeated until a determination of adequate pharmacodynamic response is obtained with the sustained release unit dosage form.
  • According to the above method, a patient may be titrated with a sustained release opioid analgesic dosage form. Subsequent maintenance therapy may be provided with the same sustained release dosage form.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The following examples illustrate various aspects of the present invention. They are not to be construed to limit the claims in any manner whatsoever.
  • Examples 1-2
  • In Example 1, morphine sulfate sustained-release beads with a 5% w/w sustained release coating comprising Eudragit® RS were prepared, including a 10% immediate release morphine sulfate overcoat. In Example 2, morphine sulfate sustained-release beads with an 8% w/w sustained-release coating comprising Eudragit® RS were prepared, including a 10% immediate release morphine sulfate overcoat.
  • Morphine sulfate beads were first manufactured using a rotor processing technique. The formula of the morphine sulfate beads to which the sustained-release coating was applied is set forth in Table 1 below:
  • TABLE 1
    Amt/Unit
    Ingredient (mg) Percent (%)
    Morphine Sulfate Powder 30 mg 14.3%
    Lactose Hydrous Impalpable 42.5 mg 20.2%
    PVP 2.5 mg 1.2%
    Sugar Beads
    18/20 125 mg 59.4%
    Purified Water qs mg
    Opadry Red YS-1-1841 10.5 mg 4.9%
    Total 210.5 mg 100.0%
  • A sustained-release coating was then applied to the morphine sulfate beads. The formula for the sustained release coating of Examples 1 and 2 is set forth in Table 2 below:
  • TABLE 2
    Example 1 Example 2
    Ingredient (mg) % (mg) %
    Morphine Base Beads 189.45 mg  86.7%  189.5 mg  83.0% 
    Retardant Coating
    Eudragit RS 30D  9.5 mg 4.3% 15.2 mg 6.7%
    Triethyl Citrate  1.9 mg 0.9%  3.0 mg 1.3%
    Talc  3.8 mg 1.7%  6.1 mg 2.7%
    Purified Water qs qs
    Overcoat
    Morphine Sulfate  3.0 mg 1.4%  3.0 mg 1.3%
    Powder
    Opadry Red 10.8 mg 5.0% 11.4 mg 5.0%
    YS-1-1841
    Purified Water qs qs
    Total 218.45 mg  100.0%  228.2 mg  100.0% 
  • The sustained-release coating was manufactured as follows. The Eudragit RS30D was plasticized with triethyl citrate and talc for approximately 30 minutes. A load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads were coated to a weight gain of 5% and 8% for Examples 1 and 2, respectively. The final protective Opadry dispersion overcoat was then applied in the Wurster Insert. Upon completion the beads were cured for two days in a dry oven of 45° C. The cured beads were then filled into gelatin capsules at a 30 mg strength.
  • Dissolution testing was conducted on the gelatin capsules via U.S.P. Apparatus II (Paddle Method). The capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated gastric fluid (without enzymes) after the first hour. The results of the percent of morphine sulfate dissolved in relation to time for Examples 1 and 2 are set forth in Table 3 below:
  • TABLE 3
    Percent Morphine
    Sulfate Dissolved
    Time Example 1 Example 2
    1 hour 11.9% 10.2%
    2 hours 15.4% 11.3%
    4 hours 28.1% 12.8%
    8 hours 58.3% 16.4%
    12 hours 79.2% 29.6%
    18 hours 92.0% 58.1%
    24 hours 96.6% 73.2%
  • Clinical Evaluation of Examples 1-2
  • Ten normal, healthy male subjects were enrolled in a four-way, randomized, single-dose, crossover pharmacokinetic/pharmacodynamic study to characterize the effect of food on the pharmacokinetic/pharmacodynamic profile of Example 1 compared with the same product and with morphine CR 30 mg tablet (MS Contin®), each in the fasted state, using plasma morphine concentration and pharmacodynamic parameters. A comparison of Example 2 with morphine controlled release 30 mg tablet (MS Contin®) was also made. Plasma morphine concentrations were used for calculation of pharmacokinetic parameters including: (a) absorption and elimination rates; (b) area under the curve (AUC); (c) maximum plasma concentration (Cmax); (d) time to maximum plasma concentration Tmax); (e) T1/2 (elimination). Pharmacodynamic effect compared with plasma concentrations of morphine was to be described from data obtained from the following pharmacodynamic parameters: mood, sedation, respiratory rate, pupillometry and an adjective questionnaire.
  • Clinical Laboratory Evaluations
  • Blood samples were collected for hematology (hemoglobin, hematocrit, red blood cell count, white blood cell count with differential, platelet count) and blood chemistry analyses (calcium, inorganic phosphate, uric acid, total protein, albumin, cholesterol, alkaline phosphatase, lactate dehydrogenase (LDH), total bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), fasting blood glucose, blood urea nitrogen (BUN), serum creatinine) pre- and post- (72 hours) study (i.e., 72 hours after Phase 4 dose). A urine sample was collected for urinalysis (specific gravity, glucose, albumin, bile, pH, acetone, microscopic examination) pre- and post- (72 hours) study (i.e., 72 hours after Phase 4 dose). A pre-study urinalysis for illicit drugs was performed during the screening process and immediately pre-dose for each administration of the study drug (Day 1 of Phases 1 through 4).
  • Plasma morphine concentrations were determined from blood samples which were drawn just prior to dosing (0 hour) and thereafter at 0.5, 1, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, 12, 18, 24, 36, 48 and 72 hours following each dose. Blood samples, each approximately 10 ml, were drawn into tubes containing ethylenediaminetetraacetic acid (EDTA) solution, an anticoagulant. Following centrifugation, the plasma was pipetted into two 5-ml polypropylene, labeled tubes and frozen at −20° C. One set of samples was shipped to the designated analytical laboratory in sufficient dry ice to keep them frozen for 2 days, and the second set was retained frozen at the study site as a back-up.
  • Pharmacodynamic Measurements
  • Measurements of the following pharmacodynamic parameters were made just prior to blood sampling at baseline (within 30 minutes prior to dosing) and thereafter at 0.5, 1, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, 12, 18, 24, 36, 48 and 72 hours following each dose.
  • Mood (measured by a visual analog scale (VAS) on a subject diary sheet)—10 minutes prior to blood sampling. The VAS was anchored on one end as Worst Mood and the other end as Best Mood.
  • Sedation (measured by VAS on a subject diary sheet)—10 minutes prior to blood sampling. The VAS was anchored on one end as Asleep and the other end as Awake.
  • Respiratory rate (breaths per minute)—within 5 minutes of blood sampling. (Data were recorded on a subject diary sheet.)
  • Pupil size—measured by pupillometry—within 5 minutes of blood sampling. Only the left eye was measured at all time periods. (Data were recorded on a subject diary sheet.)
  • FIG. 1 is a graphical representation of the mean sedation vs. time curve for Example 1 (fasted). FIG. 2 is a graphical representation of the mean sedation vs. time curve for Example 2 (fasted). FIG. 3 is a graphical representation of the mean respiratory rate vs. time curve for Example 1 (fasted). FIG. 4 is a graphical representation of the mean respiratory rate vs. time curve for Example 2 (fasted).
  • Plasma morphine concentrations were determined by a high-performance liquid chromatographic procedure. Arithmetic mean Cmax, Tmax, AUC, half-lives calculated from individual plasma morphine concentration-versus-time, and oral bioavailability data were as set forth in Tables 4 and 5 below:
  • TABLE 4
    Pharmaco- MS
    kinetic Contin ® Ex. 2 Ex. 1
    Parameter (Fast) (Fast) (Fast) (Fed)
    Cmax (ng/ml) 13.05 3.95* 5.42* 5.87*
    Tmax (hours) 2.45 15.05* 5.85 6.90
    AUC (0.72) 101.11 136.10* 109.37 111.33
    (hr-ng/ml)
    AUC (0.00) 101.31 155.44* 117.77 114.45
    (hr-ng/ml)
    T1/2 (elim; hrs) 2.81 89.68* 19.02 10.34
    T1/2 (abs; hrs) 1.20 3.96 2.51 3.48
  • TABLE 5
    Pharmaco- F0 F0 (%) F0 (%) F0 (%)
    kinetic (%) 90% C.I. 90% C.I. 90% C.I. 90% C.I.
    Parameter (B vs. A) (C vs. A) (D vs. A) (D vs. C)
    Cmax  32.24  39.88  42.50 106.57
    (ng/ml) (15.7-48.7) (23.3-56.5) (26.0-59.0) (65.2-148.0)
    Tmax 608.27 232.33 290.48 125.03
    (hours) (435.6-780.9)  (58.8-405.8)  (117.9-463.11) (50.7-199.3)
    AUC 134.53 105.02 106.04 100.97
    (0.72) (111.1-158.0)  (81.5-128.6)  (82.6-129.5) (78.6-123.3)
    (hr-ng/ml)
    AUC 151.04 112.91 108.09  95.73
    (0.00) (112.6-189.4)  (81.8-144.0)  (77.1-139.0) (68.3-123.1)
    (hr-ng/ml)
    T1/2 (elim; hrs) 3076.7  689.41 374.01  54.25
    (2256.7-3896.7)  (24.9-1353.9) (−286.8-1034.9) (−41.6-150.1) 
    T1/2 (abs; 281.21 167.18 239.86 143.48
    hrs) (−123.1-685.5)  (−11.7-346.0)  (62.4-417.3) (37.2-249.8)
    * Statistically significant (p < .0500) when compared to MS Contin ® (based on untransformed data)
    F0 (%) = Oral bioavailability (Test least squares mean/Reference least squares mean)
    (A = MS Contin; B = Example 2 fasted; C = Example 1 Fed; and D = Example 1 fasted)
  • Table 6 provides the mean (±S.D.) plasma morphine concentrations (ng/ml) following dosing with MS Contin® and Examples 1 and 2.
  • TABLE 6
    Mean (±S.D.) Plasma Morphine
    Concentrations (ng/ml) Following Dosing With
    MS Contin ® And Each Formulation Of Morphine Beads
    Time MS Contin ® Ex. 2 Ex. 1 Ex. 1
    (hours) 30 mg (Fast) (Fast) (Fast) (Fed)
    0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
    0.50 3.04 ± 2.07 2.22 ± 1.09 1.82 ± 1.35 0.51 ± 0.79
    1.00 6.78 ± 4.19 1.89 ± 0.54 2.09 ± 1.07 1.46 ± 0.95
    2.00 11.43 ± 5.70  1.60 ± 0.69 2.33 ± 0.98 2.46 ± 0.91
    2.50 10.30 ± 6.46  1.78 ± 1.16 2.22 ± 0.88 2.51 ± 0.88
    3.00 9.40 ± 5.41 1.54 ± 0.97 2.61 ± 1.12 3.47 ± 1.77
    3.50 8.09 ± 4.48 1.34 ± 0.98 2.82 ± 1.39 3.03 ± 1.26
    4.00 7.11 ± 3.78 1.06 ± 0.49 3.60 ± 2.50 3.41 ± 1.82
    5.00 7.25 ± 4.71 1.54 ± 1.21 4.09 ± 2.24 3.80 ± 1.29
    6.00 5.27 ± 3.31 1.20 ± 0.77 4.11 ± 1.74 4.23 ± 1.68
    8.00 3.19 ± 1.99 1.58 ± 1.00 3.80 ± 1.46 4.46 ± 1.51
    10.0 1.87 ± 1.00 2.62 ± 1.05 3.57 ± 1.44 4.16 ± 1.37
    12.0 1.70 ± 0.76 3.10 ± 1.64 2.83 ± 0.64 4.33 ± 2.20
    18.0 1.23 ± 0.67 3.04 ± 1.11 2.40 ± 1.13 1.85 ± 1.12
    24.0 1.38 ± 0.96 2.54 ± 0.55 1.82 ± 1.01 1.71 ± 0.73
    36.0 0.85 ± 0.64 2.58 ± 1.04 1.35 ± 0.70 1.19 ± 0.40
    48.0 0.22 ± 0.47 1.48 ± 0.48 0.69 ± 1.08 0.73 ± 0.56
    72.0 0.05 ± 0.16 0.54 ± 0.66 0.16 ± 0.33 0.22 ± 0.46
  • Table 7 provides the mean (±S.D.) pharmacokinetic parameters following dosing with MS Contin® And Examples 1-2.
  • TABLE 7
    Mean (±S.D.) Pharmacokinetic
    Parameters Following Dosing With
    MS Contin ® And Each Formulation Of Morphine Beads
    MS Contin ®
    30 mg Ex. 2 Ex. 1 Ex. 1
    Parameter (Fast) (Fast) (Fast) (Fed)
    Cmax 13.05 ± 5.22  3.95 ± 1.55 5.42 ± 2.26 5.87 ± 2.07
    (ng/ml)
    Tmax 2.45 ± 0.86 15.05 ± 9.51  5.85 ± 1.92 6.90 ± 3.18
    (hrs)
    AUC (0.72) 101.11 ± 41.913 136.10 ± 34.58  109.37 ± 43.06  111.33 ± 36.21 
    (hr-ng/ml)
  • In comparing Example 1 (fast) to MS Contin® (fast), there was a statistically significant difference in Cmax. There were no statistically significant differences between the two treatments in Tmax, AUC (0,72), AUC (O, oo) and T1/2 (elim) or T1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • In comparing Example 1 (fed) to MS Contin® (fast), there was a statistically significant difference in Cmax. There were no statistically significant differences between the two treatments in Tmax, AUC (0,72), AUC (O, oo) and T1/2 (elim) or T1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • In comparing Example 1 under fed and fasting conditions, there were no statistically significant differences in Cmax, Tmax, AUC (0,72), AUC (O, oo) and T1/2 (elim) or T1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • The effect of food on the absorption of Example 1 is characterized by a greater Cmax and extended Tmax and T1/2 (abs) values. The extent of absorption (based on AUCs), however, is less than 3% different under fed and fasted conditions.
  • In comparing Example 2 (fast) to MS Contin® (fast), there were statistically significant differences in Cmax, Tmax, AUC (0,72), AUC (O, oo) and T1/2 (elim). There was no statistically significant difference between the two treatments in T1/2 (abs). The 90% confidence intervals for all pharmacokinetic parameters were outside the 80-120% limits.
  • Based on the 90% confidence interval analysis, neither Example 1 under fasted or fed conditions nor Example 2 beads are equivalent to MS Contin® tablets. However, while neither of the experimental controlled-release morphine formulations are bioequivalent to MS Contin® tablets, both provide a relatively lower Cmax and extended Tmax and apparent T1/2 (elim) values.
  • Linear regression of each pharmacodynamic parameter on the log-transformed concentrations for each subject and treatment resulted in 48 of 240 regressions ( 48/240; 20%) having an R2 value of 20% or higher, of which 8 ( 8/240; 3%) had a value of 50% or higher. When analyzed by treatment only, all R2 values were lower than 10%. These values indicate no significant linear relationship between the pharmacodynamic measurements and the log concentrations.
  • Examination of the mean hysteresis curves revealed a possible relationship between pupil size and morphine concentration. For MS Contin® and Example 1, pupil size tended to decrease with an increase in morphine concentration, then increase as morphine concentration decreased. FIG. 5 is a graphical representation of the mean pupil size v. time curve for Example 1 (fasted). FIG. 6 is a graphical representation of the mean pupil size vs. time curve for Example 2 (fasted). No relationship was observed between morphine concentrations and any of the other parameters.
  • Two subjects (20%) reported six adverse experiences while receiving MS Contin®. Three subjects (30%) reported six adverse experiences while receiving controlled-release morphine beads (Example 1; fasted). One subject in each of the following treatment groups reported a single adverse experience: Example 1 (fed) and Example 2 (fasted). No clinically significant changes in physical examination or EKG results, clinical laboratory values or vital sign measurements occurred during the study.
  • Modified Specific Drug Effect Questionnaire
  • The questionnaire was a modification of the 22-item questionnaire used by Jasinski, D. R. (1977) Assessment of the Abuse Potential of Morphine-Like Drugs (Methods Used in Man). In Drug Addiction I (Martin, W. R., ed.) pp. 197-258. Springer-Verlag, New York; and Preston, K. L., Jasinski, D. R., and Testa, M. (1991) Abuse Potential and Pharmacological Comparison of Tramadol and Morphine. Drug and Alcohol Dependence 27:7-17. The questionnaire consisted of 10 items to be rated by the subject and observer. The items were related to signs of opiate-agonist drugs and were as follows:
  • Subject's Questions
  • 1. Do you feel any effects of the drugs?
    2. Is your skin itchy?
    3. Are you relaxed?
    4. Are you sleepy?
    5. Are you drunk?
    6. Are you nervous?
    7. Are you full of energy?
    8. Do you need to talk?
    9. Are you sick to your stomach?
    10. Are you dizzy?
    The subject rated each of these questions by placing a vertical mark along a 100-mm VAS anchored at one end by “not at all” and at the other end by “an awful lot”.
  • Observer's Questions
  • 1. Is the subject showing any drug effect?
    2. Is the subject scratching?
    3. Is the subject relaxed?
    4. Is the subject drunk?
    5. Is the subject nervous?
    6. Is the subject talking?
    7. Is the subject vomiting?
    8. Is the subject confused?
    9. Is the subject restless?
    10. Is the subject perspiring?
  • The observer rated each of these questions by placing a vertical mark along a 100-mm VAS anchored at one end by “not at all” and at the other end by “extremely”. FIG. 7 is a graphical representation of the means subject questionnaire vs. time curve for Example 1 (fasted). FIG. 8 is a graphical representation of the means subject questionnaire vs. time curve for Example 2 (fasted).
  • Adverse Experiences
  • Adverse experiences, whether spontaneously reported or elicited upon direct questioning, were recorded and evaluated promptly by the principal investigator to determine the severity, duration and initiation of corrective measures, if warranted. Subjects were to be followed until they returned to baseline status.
  • Analytical
  • Plasma morphine analyses were conducted using high performance liquid chromatography (HPLC). The limit of quantification was 0.5 ng/mL. Appendix V contains the plasma morphine analytical report.
  • Statistical and Pharmacometric Methods
  • Parameters
  • The serial plasma morphine values, collected from each subject and treatment, were corrected for the zero-hour value by subtraction of the zero-hour value from all subsequent values in that series.
  • Any serial dataset in which the zero-hour value exceeded the minimum assay sensitivity was, as noted above, deemed inadmissible for data analysis. The following parameters were estimated for each subject and treatment, using the baseline-corrected plasma levels:
      • Cmax (ng/ml)—largest observed plasma morphine value
      • Tmax (hours)—time of occurrence of Cmax, relative to time of dosing
      • T1/2 (elim; hours)—apparent half-life of plasma morphine elimination calculated according to:

  • T1/2(elim)−0.693/Ke
      • where Ke is the terminal first-order apparent elimination rate constant calculated by PROC NLIN in SAS Release 6.07 (SAS Institute, Cary, N.C.).
      • T1/2 (abs; hrs)—apparent half-life of absorption calculated according to:

  • T1/2(abs)−0.693/Ka
  • FIG. 9 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 1 (fed and fasted) and Example 2 (fasted).
  • From the results set forth above, it can be seen that the formulation of Example 1 attains a higher and earlier Cmax but a slightly lower extent of morphine absorption than the formulation of Example 2. Visual examination of the time-action data in respect to sedation, respiratory rate, pupil size, and combined scores from a questionnaire of opioid effects reported by the subjects at serial times following each treatment reveals greater degree of intensity of each pharmacodynamic endpoint during the earlier (e.g., 4-8 hours) portion of the time-action curves.
  • Example 3
  • Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor. The formulation of the high load beads is set forth in Table 8 below:
  • TABLE 8
    High Load
    Bead Percent
    Ingredient mg/unit (%)
    Morphine Sulfate Powder 30.0 mg 63.3%
    Lactose  6.0 mg 12.7%
    Povidone C-30 1.25 mg 2.6%
    Sugar Beads 7.75 mg 16.4%
    Opadry 2.37 mg 5.0%
    Purified Water qs
    Total 47.37 mg  100.0%
  • The sustained-release coating comprised an acrylic polymer (i.e., Eudragit® RL). A HPMC protective coat was also included between the Eudragit layer and the morphine immediate release layer to further enhance stability. The formula of the sustained release coating of Example 1 is set forth in Table 9 below:
  • TABLE 9
    Amt/Unit Percent
    Ingredient (mg) (%)
    Morphine (high load) base beads 42.63 mg  78.8%
    Retardant Coating
    Eudragit RS 30D  2.1 mg 3.9%
    Eudragit RL 30D 0.05 mg 0.1%
    Triethyl Citrate 0.45 mg 0.8%
    Talc 0.85 mg 1.6%
    Overcoatings
    Opadry Blue YS-1-10542A 2.45 mg 4.5%
    Purified Water qs
    Morphine Sulfate Powder  3.0 mg 5.5%
    Opadry Blue YS-1-10542A 2.55 mg 4.8%
    Purified Water qs
    Total 54.08 mg  100.0%
  • The sustained release and the immediate release coatings were applied as follows. The Eudragit RL 30D was plasticized with triethyl citrate and talc for approximately 30 minutes. A load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 5%. The final protective Opadry dispersion overcoat was then applied in the Wurster Insert. Upon completion the beads were cured for two days in a dry oven of 45° C. The cured beads were then filled into gelatin capsules at a 30 mg strength. The cured beads were then filled into gelatin capsules at a strength of 30 mg.
  • The capsules were then subjected to dissolution testing. Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method). The capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated gastric fluid (without enzymes) after the first hour. The results of dissolution testing is set forth in Table 10 below:
  • TABLE 10
    Percent Morphine
    Time Sulfate Dissolved
     1 hour 11.7%
     2 hours 12.1%
     4 hours 22.0%
     8 hours 45.3%
    12 hours 63.7%
    18 hours 81.8%
    24 hours 92.5%
  • Clinical Evaluation of Example 3
  • Thirteen normal, healthy male subjects were enrolled in this five-way crossover, randomized, open-label study assessing the effect of food on the pharmacokinetics and pharmacodynamics of single 30-mg doses (capsules) of Example 3. The pharmacokinetic and pharmacodynamic results of the extended-release formulations in these fed and fasted subjects were also compared with those of MS Contin® 30 mg tablets in fasted subjects. Plasma morphine level was used to calculate pharmacokinetic parameters including: (a) apparent absorption and elimination rates; (b) area-under-the-curve (AUC); (c) maximum plasma concentration (Cmax); (d) time to maximum plasma concentration (Tmax); (e) T1/2 (abs), and (f) T1/2 (elim). Pharmacodynamic effects were assessed based on evaluations of mood, sedation, respiratory rate, pupillometry, and subject's adjective questionnaire.
  • Plasma morphine concentrations were determined by a high-performance liquid chromatographic procedure. All subjects completed the study and were included in the biopharmaceutical analysis. Arithmetic mean Cmax, Tmax, AUC, half-lives calculated from individual plasma morphine concentration-versus-time, and oral bioavailability data are set forth in Tables 11 and 12 below:
  • TABLE 11
    Pharmaco-
    kinetic Ex. 3 Ex. 3 MS Contin ®
    Parameter (Fed) (Fast) (Fasted)
    Cmax (ng/ml) 5.45 4.03 11.65
    Tmax (hours) 8.04 12.92 2.77
    AUC (0.72) (hr-ng/ml) 118.12 140.79 114.05
    AUC (0.00) (hr-ng/ml) 137.67 166.19 114.05
    T1/2 (elim; hrs) 21.19 54.51 1.26
    T1/2 (abs; hrs) 3.12 2.44 3.34
  • TABLET 12
    Pharmaco- F0 (%) Ex. 3 vs.
    kinetic 90% C.I. MS Contin ®
    Parameter (Ex 3: Fed vs. Fast) (Both Fasted)
    Cmax 164.36 29.54
    (ng/ml) (113.1-215.6)  (14.3-44.7)
    Tmax 53.49 514.28
    (hours) (13.3-93.7)  (306.8-721.7)
    AUC (0.72) 89.93 119.35
    (hr-ng/ml) (64.8-115.1)  (89.2-149.5)
    AUC (0.00) 86.56 143.48
    (hr-ng/ml) (62.5-110.6) (108.6-178.1)
    T1/2 (elim; hrs) 34.53 1609.0
    (7.4-61.7) (1170-2048)
    T1/2 (abs; hrs) 135.27 191.45
    (83.5-187.0)  (92.0-290.9)
    F0 (%) = Oral bioavailability (Test mean/Reference mean)
  • Table 13 provides the mean (±S.D.) plasma morphine concentrations (ng/ml) following dosing with MS Contin® and Example 3.
  • TABLE 13
    Mean Plasma Morphine Concentrations ±
    Standard Deviation Following Administration
    Time Ex. 3 Ex. 3 MS Contin ®
    (hours) 30 mg Fed 30 mg Fasted 30 mg Fasted
    0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
    0.50 0.201 ± 0.447 2.00 ± 1.48 3.42 ± 1.82
    1.00 0.331 ± 0.479  2.27 ± 0.799 6.09 ± 2.03
    2.00 1.65 ± 1.53  2.19 ± 0.936 8.82 ± 2.61
    2.50 3.06 ± 1.04  2.20 ± 0.798 9.12 ± 2.97
    3.00 3.53 ± 1.82 2.24 ± 1.05 9.91 ± 5.32
    3.50 3.06 ± 1.16 2.87 ± 1.94 8.83 ± 3.58
    4.00 3.23 ± 1.04 2.33 ± 1.13 8.12 ± 3.26
    5.00 4.01 ± 1.50  2.91 ± 0.933 7.79 ± 3.47
    6.00 4.00 ± 2.09 2.96 ± 1.24 6.07 ± 3.69
    8.00 4.03 ± 1.90 2.58 ± 1.24 4.68 ± 3.88
    10.0 3.95 ± 1.89  1.95 ± 0.965 2.61 ± 1.43
    12.0 3.20 ± 1.47  2.18 ± 0.983  1.58 ± 0.815
    18.0 2.06 ± 1.02 2.75 ± 1.53  1.46 ± 0.745
    24.0  2.10 ± 0.963  2.72 ± 0.971  1.34 ± 0.890
    36.0 1.66 ± 1.05 2.65 ± 1.18  1.08 ± 0.971
    48.0 0.872 ± 0.681  1.53 ± 0.851 0.528 ± 0.831
    72.0 0.300 ± 0.529 0.468 ± 0.650 0.00 ± 0.00
  • Table 14 provides the mean (±S.D.) pharmacokinetic parameters following dosing with MS Contin® And Example 3.
  • TABLE 14
    Mean Pharmacokinetic Parameters ± Standard
    Deviation Following Administration of Each Formulation
    Ex. 3 Ex. 3 Ms Contin ®
    Parameter
    30 mg Fed 30 mg Fasted 30 mg Fasted
    Cmax 5.45 ± 1.68 4.03 ± 1.55 11.65 ± 4.82
    (ng/ml)
    Tmax 8.04 ± 8.31 12.92 ± 14.66  2.77 ± 0.927
    (hrs)
    AUC (0.72) 118.12 ± 36.77  140.79 ± 51.23  114.05 ± 42.42
    (hr-ng/ml)
  • The ratios of least-squares mean AUC for the 30 mg capsules of Example 3 given under fed and fasted conditions indicate that AUC values under fed conditions are within ±20% of those under fasted conditions. The value of Cmax was 64% greater under fed conditions. The value of Tmax under fed conditions was approximately 50% of that when given under fasted conditions. The apparent absorption rate was approximately 35% greater under fed conditions, and the apparent elimination rate under fed conditions was approximately 35% of that under fasted conditions, indicating that absorption of morphine is slowed by the presence of food, and elimination rate is increased.
  • The ratios of least-squares mean AUC for the 30 mg capsule of Example 3 and the MS Contin® 30 mg tablet indicate that AUC (0,72) values for Example 3 are within ±20% of those for MS Contin®, and AUC (0,00) values are 44% greater for Example 3. The value of Cmax for Example 3 was 29.5% of that for MS Contin®. The value of Tmax under fed conditions was over five times that for Example 3. The apparent absorption rate was approximately 91% greater for Example 3, and the apparent elimination rate for Example 3 was over 16 times that for MS Contin®, indicating that absorption and elimination of morphine is slower for Example 3.
  • Linear regression of each pharmacodynamic parameter on the log-transformed concentrations for each subject and treatment resulted in 74 of 315 regressions (24%) having an R2 value of 20% or higher, and 12 of 315 (4%) having a value of 50% or higher. When analyzed by treatment only, there were zero R2 values higher than 10%. Of those individual R2 values above 20%, 21 occurred in the 63 regressions (33%) of Subject's Modified Specific Drug Effect Questionnaire scores on log concentration, and 7 of the 63 (11%) were above 50%. These values indicate a possible linear relationship between the log concentrations and Subject's MSDEQ scores. Examination of the mean hysteresis curves also reveals a possible relationship between morphine concentration and Subject's MSDEQ scores. For each formulation, Subject Modified Specific Drug Effect Questionnaire scores tended to increase with an increase in morphine concentration, then decrease as morphine concentration decreased. No relationships were observed between morphine concentrations and any of the other pharmacodynamic parameters.
  • FIG. 10 is a graphical representation of the mean plasma morphine concentration-time profile obtained with the Comparative Example (MS Contin 30 mg) (fasted) as compared to the capsules of Example 3 (fed and fasted). FIG. 11 is a graphical representation of the mean sedation vs. time curve for Example 3 (fasted). FIG. 12 is a graphical representation of the mean respiratory rate vs. time curve for Example 3 (fasted). FIG. 13 is a graphical representation of the mean pupil size v. time curve for Example 3 (fasted). FIG. 14 is a graphical representation of the mean subject modified specific drug effect questionnaire vs. time curve for Example 2 (fasted).
  • Example 4
  • Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor. The formulation of the high load beads is set forth in Table 15 below.
  • TABLE 15
    High Load Percent
    Ingredient Bead mg/unit (%)
    Morphine Sulfate Powder 60.0 mg 56.4%
    Lactose 12.0 mg 11.3%
    Eudragit RS30D 4.16 mg  3.9%
    Povidone C-30 8.31 mg  7.8%
    Sugar Beads 16.80 mg  15.8%
    Opadry 5.06 mg  4.8%
    Purified Water qs
    Total 106.33 mg  100%
  • These immediate release base beads were manufactured using the powder layering technique in the Glatt Rotor Processor.
  • The sustained release coating comprised an ethylcellulose acrylic polymer (i.e., Aquacoat ECD 30). A HPMC protective coat was also included after the Aquacoat layer to further enhance stability. The formula of the sustained-release coating of Example 1 is set forth in Table 16 below.
  • TABLE 16
    Ingredient Amt/Unit (mg) Percent (%)
    Morphine (high load) 106.33 mg  73.1%
    based beads
    Retardant Coating
    Aquacoat ECD
    30 23.13 mg  15.9%
    Methocel E5 Premium 3.46 mg 2.4%
    Triethyl Citrate 5.32 mg 3.6%
    Purified Water qs
    Final Overcoat
    Opadry Blue YS-1-10542A 7.28 mg 5.0%
    Purified Water qs
    Total 54.08 mg  100.0%
  • The sustained release coating and final overcoat were applied as follows: The combination of Aquacoat ECD 30 and Methocel E5 Premium was plasticized with triethyl citrate for approximately 30 minutes. A load of morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 25%. Upon completion of the Retardant the beads were cured for 3 days in a Temperature/Humidity Chamber of 60° C./80% RH. The cured beads were then dried for 1 day in a dry oven of 60° C. The cured dried beads were charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the final protective Opadry dispersion overcoat was then applied. The finished sustained release beads along with the Low Load Immediate Release Morphine Sulfate beads were individually filled into the same gelatin capsules at a combined strength of 60 mg. The sustained released beads comprised 90% or 54 mg of strength and the Immediate Release Beads comprised 10% or 6 mg of the capsule strength.
  • The capsules were then subjected to dissolution testing. Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method). The capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour. The results of dissolution testing is set forth in Table 17 below.
  • TABLE 17
    Time % Morphine Sulfate Dissolved
     1 hour 10.4%
     2 hours 11.4%
     4 hours 17.5%
     8 hours 31.8%
    12 hours 54.0%
    18 hours 88.6%
    24 hours 102.3%
  • Example 5
  • Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor. The formulation of the high load beads is set forth as per Table 18 in Example 5.
  • The sustained-release coating comprised an acrylic polymer (i.e., Eudragit® RS/RL). A HPMC protective coating was also included after the Eudragit layer to further enhance stability. The formula of the sustained-release coating of Example 5 is set forth in Table 18 below.
  • TABLE 18
    Ingredient Amt/Unit (mg) Percent (%)
    Morphine (high load) 106.33 mg  87.96% 
    based beads
    Retardant Coating
    Eudragit RS 30 D 5.05 mg 4.18%
    Eudragit RL 30 D 0.27 mg 0.22%
    Triethyl Citrate 1.06 mg 0.88%
    Talc 2.13 mg 1.76%
    13/20 Final Overcoat
    Opadry Blue YS-1-10542A 6.04 mg  5.0%
    Purified Water qs
    Total 120.88 mg  100.0% 
  • The sustained-release and the final coatings were applied as follows. The Eudragit RS/RL 30D was plasticized with triethyl citrate and talc for approximately 30 minutes. A load of the morphine sulfate beads was charged into a Wurster Insert of a Glatt equipped with a 1.2 mm spray nozzle and the beads are coated to a weight gain of 5%. The final protective Opadry dispersion overcoat was then applied in the Wurster Insert. Upon completion the beads were cured for two days in a dry oven of 45° C. The cured beads were then filled into gelatin capsules at a 60 mg strength.
  • The capsules were then subjected to dissolution testing. Dissolution testing was conducted on the finished products via USP Apparatus II (Paddle Method). The capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour. The results of dissolution testing is set forth in Table 19 below.
  • TABLE 19
    Time % Morphine Sulfate Dissolved
     1 hour 10.4%
     2 hours 11.4%
     4 hours 17.5%
     8 hours 31.8%
    12 hours 54.0%
    18 hours 88.6%
    24 hours 102.3%
  • Example 6 Matrix Beads
  • Matrix Beads with a higher loading of morphine sulfate were produced with the use of the powder layering technique in the Glatt Rotor Processor. The formulation of the high load matrix beads is set forth in Table 20 below.
  • TABLE 20
    High Load Percent
    Ingredient Bead mg/unit (%)
    Morphine Sulfate Powder 60.0 mg 46.0%
    Lactose 12.0 mg  9.2%
    Eudragit RS30D 29.10 mg  22.4%
    Povidone C-30 5.80 mg  4.5%
    Sugar Beads 16.80 mg  12.9%
    Opadry 6.50 mg  5.0%
    Purified Water qs
    Total 130.20 mg  100%
  • The matrix component is comprised of an ethylcellulose polymer (i.e., Aquacoat ECD 30). A HPMC protective coat was also included after the aquacoat layer to further enhance stability.
  • The matrix beads were made as follows. The Aquacoat ECD 30 was plasticized with tributyl citrate for approximately 30 minutes. Morphine sulfate powder and lactose were blended for approximately 5 minutes in a hobart mixer. A load of sugar beads was charged into the rotor insert of a Glatt equipped with a 1.2 mm spray nozzle/powder feed assembly. An Accurate Powder Feeder was positioned over the spray nozzle/powder feed assembly and charged with the morphine sulfate/lactose blend. The morphine sulfate/lactose blend is then layered onto the sugar beads using the plasticized hydrophobic polymer dispersion (i.e., Aquacoat ECD 30 and tributyl citrate) as the binding agent. Upon completion of the layering process the final protective Opadry dispersion overcoat was then applied. The beads were then cured for one day in a dry oven of 60° C. The cured beads were then filled into gelatin capsules at a 60 mg strength.
  • The capsules were then subjected to dissolution testing. Dissolution testing was conducted on the finished products via USP Apparatus II-(Paddle Method). The capsules were placed into 700 ml of simulated gastric fluid (without enzymes) for the first hour at 100 rpm and 37° C., and then placed into 900 ml of simulated intestinal fluid (without enzymes) after the first hour. The results of dissolution testing is set forth in Table 21 below.
  • TABLE 21
    Time % Morphine Sulfate Dissolved
     1 hour 32.4%
     2 hours 44.8%
     4 hours 59.6%
     8 hours 76.6%
    12 hours 88.0%
    18 hours 97.6%
    24 hours 102.2%
  • Clinical Evaluation of Examples 4, 5 and 6
  • Fourteen normal healthy human subjects were enrolled in a six way crossover, randomized, open label study assessing the effect of food on the pharmacokinetics and pharmacodynamics of a single dose of either example 1, 2 or 3, with or without food. Plasma samples were analyzed for morphine levels and the following pharmacokinetic results were calculated, and the results are set forth in Table 22 below.
  • TABLE 22
    Pharmacokinetic Parameter Per 60 mg Dose
    Example AUC Cmax Tmax
    Number (ng/ml · hr) (ng/ml) (hours)
    1 Fasted 120 6.1 5.5
    1 Fed 131 8.3 8.8
    2 Fasted 149 11.3 6.7
    2 Fed 159 11.5 6.4
    3 Fasted 154 14.3 1.8
    3 Fed 154 12.7 2.8
  • Example 7 Hydromorphone HCl 8 mg Once-A-Day Capsules Drug Loading
  • Hydromorphone beads were prepared by dissolving hydromorphone HC in water, adding Opadry Y-5-1442 and mixing for about 1 hour to obtain a 20% w/w suspension. This suspension was then sprayed onto Nu-Pareil 18/20 mesh beads using a Wurster insert.
  • First Overcoat
  • The loaded hydromorphone beads were then overcoated with a 5% w/w gain of Opadry Light Pink using a Wurster insert. This overcoat was applied as a protective coating.
  • Retardant Coat
  • After the first overcoat, the hydromorphone beads were then coated with a 5% weight gain of a retardant coating mixture of Eudragit RS 30D and Eudragit RL 30D at a ratio of 90:10, RS to RL. The addition of Triethyl Citrate (a plasticizer) and Talc (anti-tacking agent) was also included in the Eudragit suspension. The Wurster insert was used to apply the coating suspension.
  • Second Overcoat
  • Once the retardant coating was complete, the hydromorphone beads were given a final overcoat of Opadry Light Pink to a 5% weight gain using a Wurster insert. This overcoat was also applied as a protective coating.
  • Curing
  • After the completion of the final overcoat, the hydromorphone beads were cured in a 45° C. oven for 2 days.
  • Encapsulation
  • Beads were hand filled in size #2 clear gelatin capsules at an 8 mg strength of Hydromorphone HCl.
  • The formulation for Example 7 is set forth in Table 23 below:
  • TABLE 23
    HYDROMORPHONE HCl 8 mg ONCE A DAY CAPSULES
    Ingredient mg/Capsule
    Loading
    Hydromorphone HCl 8.00
    Opadry Light Pink (Y-5-1442) 4.00
    Purified Water1 q.s.
    18/20 Mesh Sugar Spheres 148.00
    Overcoating
    Opadry Light Pink (Y-5-1442) 8.40
    Purified Water1 q.s.
    Retardant Coating
    Eudragit RS 30D2 7.60
    Eudragit RL 30D2 0.80
    Triethyl Citrate 1.68
    Talc 3.36
    Purified Water1 q.s.
    Second Overcoating
    Opadry Light Pink (Y-5-1442) 9.60
    Purified Water1 q.s.
    Encapsulation
    Size #
    2 Clear Hard Gelatin Capsules n/a
    Total Fill Weight 191.44 mg
    1Used in processing and remains as residual moisture only.
    2Dry weight.
  • Dissolution Testing
  • The above capsules were tested using USP methodology and were found to have the following results:
  • Time Initial
     1 hour 17.2
     2 hours 48.4
     4 hours 77.4
     8 hours 93.3
    12 hours 97.2
    18 hours 98.8
    24 hours 98.8
  • A single-dose randomized, crossover bioavailability study was conducted with the above 8 mg controlled release hydromorphone HCl capsules and two immediate release 4 mg tablets) (Dilaudid®) as the reference in fed and fasted conditions. Blood samples were assayed for hydromorphone levels and the following pharmacokinetic parameters were calculated. The results are provided in Table 24 below:
  • TABLE 24
    AUC Tmax Cmax T1/2
    Group (pg/ml/hr) % IR (hr) (pg/ml) (abs)
    CR Fasted* 21059 101 4.9 1259 2.56
    CR Fed* 25833 106 4.6 1721 3.92
    IR Fasted** 20903 100 0.85 3816 0.18
    IR Fed** 24460 100 1.15 3766 0.32
    *CR = Example 7
    **IR = Dilaudid
  • The examples provided above are not meant to be exclusive. Many other variations of the present invention would be obvious to those skilled in the art, and are contemplated to be within the scope of the appended claims.

Claims (15)

1-7. (canceled)
8. The formulation of claim 27, wherein the amount of hydromorphone consists of from about 2 mg to about 64 mg.
9-11. (canceled)
12. The sustained release formulation of claim 27, wherein said retardant material is selected from the group consisting of an acrylic polymer, an alkylcellulose, shellac, zein, hydrogenated vegetable oil, hydrogenated castor oil, and mixtures of any of the foregoing.
13-26. (canceled)
27. An oral sustained release opioid formulation comprising a plurality of substrates comprising hydromorphone or a salt thereof,
wherein the surfaces of the plurality of substrates are coated with a sustained release coating comprising:
a plasticizer,
an anti-tacking material, and
an effective amount of at least one retardant material,
wherein the retardant material of the sustained release coating produces a weight gain level from about 2 to about 30 percent; and
wherein said formulation provides a maximum plasma concentration (Tmax) of hydromorphone in about 2 to about 10 hours and a maximum plasma concentration (Cmax) which is more than twice the plasma level of hydromorphone at about 24 hours after administration of the formulation to a human patient.
28. The formulation of claim 27, wherein the plurality of substrates comprises a multiparticulate system that is selected from the group consisting of: beads, spheroids, microspheres, seeds, pellets, and ion-exchange resin beads.
29. The formulation of claim 28, wherein the plurality of substrates is beads.
30. The formulation of claim 29, wherein the beads are inert pharmaceutical beads.
31. The formulation of claim 30, wherein the inert pharmaceutical beads may be from about 8 mesh to about 50 mesh.
32. The formulation of claim 27, wherein said formulation provides effective treatment of pain for about 24 hours or more administration to a human patient.
33. The formulation of claim 12, wherein the retardant material is an acrylic polymer.
34. The formulation of claim 33, wherein the acrylic polymer is an acrylic resin lacquer in the form of an aqueous dispersion.
35. The formulation of claim 12, wherein the retardant material is an alkylcellulose.
36. The formulation of claim 35, wherein the alkylcellulose is ethylcellulose.
US12/653,109 1993-11-23 2009-12-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level Abandoned US20100209351A1 (en)

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US08/578,688 US5672360A (en) 1993-11-23 1994-11-22 Method of treating pain by administering 24 hour oral opioid formulations
PCT/US1994/013606 WO1995014460A1 (en) 1993-11-23 1994-11-22 Opioid formulations for treating pain
US08/938,898 US20020058050A1 (en) 1993-11-23 1997-09-26 Treating pain by administering 24 hours opioid formulations exhibiting rapid rise of drug level
US10/162,132 US20030035837A1 (en) 1993-11-23 2002-06-04 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/501,661 US20060269604A1 (en) 1993-11-23 2006-08-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
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US08/156,468 Expired - Lifetime US5478577A (en) 1991-12-24 1993-11-23 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US08/578,688 Expired - Lifetime US5672360A (en) 1993-11-23 1994-11-22 Method of treating pain by administering 24 hour oral opioid formulations
US08/938,898 Abandoned US20020058050A1 (en) 1993-11-23 1997-09-26 Treating pain by administering 24 hours opioid formulations exhibiting rapid rise of drug level
US10/162,132 Abandoned US20030035837A1 (en) 1993-11-23 2002-06-04 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/501,661 Abandoned US20060269604A1 (en) 1993-11-23 2006-08-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,316 Abandoned US20080031963A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,393 Abandoned US20070237833A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,349 Abandoned US20070237832A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US12/653,116 Abandoned US20100209514A1 (en) 1993-11-23 2009-12-08 Method of treating pain by administering 24 hour oral oploid formulations exhibiting rapid rate of initial rise of plasma drug level
US12/653,109 Abandoned US20100209351A1 (en) 1993-11-23 2009-12-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level

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US08/156,468 Expired - Lifetime US5478577A (en) 1991-12-24 1993-11-23 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US08/578,688 Expired - Lifetime US5672360A (en) 1993-11-23 1994-11-22 Method of treating pain by administering 24 hour oral opioid formulations
US08/938,898 Abandoned US20020058050A1 (en) 1993-11-23 1997-09-26 Treating pain by administering 24 hours opioid formulations exhibiting rapid rise of drug level
US10/162,132 Abandoned US20030035837A1 (en) 1993-11-23 2002-06-04 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/501,661 Abandoned US20060269604A1 (en) 1993-11-23 2006-08-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,316 Abandoned US20080031963A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,393 Abandoned US20070237833A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US11/760,349 Abandoned US20070237832A1 (en) 1993-11-23 2007-06-08 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US12/653,116 Abandoned US20100209514A1 (en) 1993-11-23 2009-12-08 Method of treating pain by administering 24 hour oral oploid formulations exhibiting rapid rate of initial rise of plasma drug level

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9861629B1 (en) 2015-10-07 2018-01-09 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition

Families Citing this family (223)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460972A (en) * 1991-04-08 1995-10-24 Research Foundation Of The State University Of New York Ionized magnesium2+ concentrations in biological samples
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
PL174197B1 (en) * 1992-10-26 1998-06-30 Goedecke Ag Thylidine dihydroorthophosphate, method of obtaining same and pharmaceutical preparation containing that compound
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
SE9301057L (en) 1993-03-30 1994-10-01 Pharmacia Ab Controlled release preparation
IL119660A (en) * 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en) * 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
EP0672416A1 (en) * 1994-03-14 1995-09-20 Euro-Celtique S.A. Pharmaceutical composition comprising diamorphine
US6077533A (en) * 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
US7060293B1 (en) 1994-05-25 2006-06-13 Purdue Pharma Powder-layered oral dosage forms
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5914131A (en) * 1994-07-07 1999-06-22 Alza Corporation Hydromorphone therapy
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US20020006438A1 (en) * 1998-09-25 2002-01-17 Benjamin Oshlack Sustained release hydromorphone formulations exhibiting bimodal characteristics
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
CA2223768A1 (en) * 1995-06-09 1996-12-27 R.P. Scherer Corporation Suspension and soft gelatin capsules containing particulate matter
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
NZ324988A (en) * 1995-12-07 1999-08-30 Lilly Co Eli Composition for treating pain comprising a selected muscarinic compound and an analgesic or nsaid
US6245351B1 (en) 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
PL188919B1 (en) * 1996-03-08 2005-05-31 Nycomed Danmark As Multiple-unit pharmaceutic composition of modifiable release
GB9614902D0 (en) * 1996-07-16 1996-09-04 Rhodes John Sustained release composition
DE19630035A1 (en) * 1996-07-25 1998-01-29 Asta Medica Ag Tramadol multiple unit formulations
BE1010803A3 (en) * 1996-12-16 1999-02-02 Therabel Research Sa Tablets pharmaceutical sustained release tramadol a basic and their preparation.
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6962997B1 (en) 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
PT1009387E (en) * 1997-07-02 2006-08-31 Euro Celtique Sa STABILIZED CONTROLLED FREQUENCY FORMULATIONS OF TRAMADOL
AU9062998A (en) * 1997-09-11 1999-03-29 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (nsaids)
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
TW477702B (en) 1997-10-23 2002-03-01 Dev Center Biotechnology Controlled release tacrine dosage form
ATE323491T1 (en) 1997-12-22 2006-05-15 Euro Celtique Sa PERORALLY ADMINISTERED MEDICINAL FORM CONTAINING A COMBINATION OF AN OPIOID AGONIST AND NALTREXONE
EP0928610A1 (en) * 1998-01-08 1999-07-14 Development Center For Biotechnology Controlled release tacrine dosage form
FR2774910B1 (en) * 1998-02-16 2001-09-07 Ethypharm Lab Prod Ethiques MORPHINE SULFATE MICROGRANULES, METHOD OF MANUFACTURE AND PHARMACEUTICAL PREPARATIONS
ATE265846T1 (en) * 1998-02-25 2004-05-15 Abbott Lab SUSTAINED RELEASE FORMULATIONS CONTAINING BUTORPHANOL
US8524277B2 (en) * 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
ES2221370T3 (en) * 1998-04-03 2004-12-16 Egalet A/S COMPOSITION OF CONTROLLED RELEASE.
CO5070568A1 (en) 1998-05-22 2001-08-28 Eurand Internatrional Spa LAYER AND APPLIANCE APPLICATION PROCESS FOR EFFECT
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
US8545880B2 (en) * 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
US6765010B2 (en) * 1999-05-06 2004-07-20 Pain Therapeutics, Inc. Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects
FR2794646B1 (en) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques MORPHINE SULFATE MICROGRANULES, METHOD OF PREPARATION AND COMPOSITION CONTAINING THEM
CN100387228C (en) * 1999-08-27 2008-05-14 布鲁克伍德药品公司 Injectable buprenorphine microparticle compositions and their use
NZ517559A (en) * 1999-08-31 2004-08-27 Gruenenthal Chemie Sustained release pharmaceutical composition containing tramadol saccharinate
US6339105B1 (en) * 1999-10-12 2002-01-15 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
US10179130B2 (en) * 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
HU230828B1 (en) 1999-10-29 2018-08-28 Euro Celtique Sa Controlled release hydrocodone formulations
EP2517710B1 (en) 2000-02-08 2015-03-25 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
EP2283829A1 (en) 2000-10-30 2011-02-16 Euro-Celtique S.A. Controlled release hydrocodone formulations
US6749867B2 (en) 2000-11-29 2004-06-15 Joseph R. Robinson Delivery system for omeprazole and its salts
US7858118B2 (en) * 2001-04-11 2010-12-28 Galephar Pharmaceutical Research, Inc. Extended release composition containing Tramadol
UA81224C2 (en) * 2001-05-02 2007-12-25 Euro Celtic S A Dosage form of oxycodone and use thereof
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1525851A (en) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ Abuse-resistant controlled-release opioid dosage form
US20030064122A1 (en) * 2001-05-23 2003-04-03 Endo Pharmaceuticals, Inc. Abuse resistant pharmaceutical composition containing capsaicin
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
EP2311460A1 (en) * 2001-07-06 2011-04-20 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
ES2292775T3 (en) * 2001-07-06 2008-03-16 Penwest Pharmaceuticals Co. FORMULATIONS OF PROLONGED RELEASE OF OXIMORPHONE.
ATE419039T1 (en) 2001-07-18 2009-01-15 Euro Celtique Sa PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
RS12104A (en) 2001-08-06 2007-04-10 Euroceltique S.A., Opioid agonist formulations with releasable and sequestered antagonist
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
EP1429728A1 (en) * 2001-08-29 2004-06-23 SRL Technologies, Inc. Sustained release preparations
EP1429744A1 (en) * 2001-09-21 2004-06-23 Egalet A/S Morphine polymer release system
EP1429739A1 (en) * 2001-09-21 2004-06-23 Egalet A/S Polymer release system
US7854230B2 (en) * 2001-10-22 2010-12-21 O.R. Solutions, Inc. Heated medical instrument stand with surgical drape and method of detecting fluid and leaks in the stand tray
PE20030527A1 (en) 2001-10-24 2003-07-26 Gruenenthal Chemie DELAYED-RELEASE PHARMACEUTICAL FORMULATION CONTAINING 3- (3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME AND ORAL TABLETS CONTAINING IT
HUP0401978A3 (en) * 2001-11-07 2008-07-28 Synthon Bv Tamsulosin tablets
US8128957B1 (en) * 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
LT2425821T (en) 2002-04-05 2017-07-25 Euro-Celtique S.A. Pharmaceutical preparation containing oxycodone and naloxone
WO2003092648A1 (en) * 2002-04-29 2003-11-13 Alza Corporation Methods and dosage forms for controlled delivery of oxycodone
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
CN1671358A (en) * 2002-05-31 2005-09-21 阿尔扎公司 Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
ES2665999T3 (en) 2002-05-31 2018-04-30 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of buprenorphine
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK1551372T3 (en) * 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
AU2003272601B2 (en) * 2002-09-20 2009-05-07 Alpharma Pharmaceuticals, Llc Sustained-release opioid formulations and methods of use
US8623412B2 (en) * 2002-09-23 2014-01-07 Elan Pharma International Limited Abuse-resistant pharmaceutical compositions
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20040110781A1 (en) * 2002-12-05 2004-06-10 Harmon Troy M. Pharmaceutical compositions containing indistinguishable drug components
EP2959893A1 (en) * 2002-12-13 2015-12-30 DURECT Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
DE10300325A1 (en) 2003-01-09 2004-07-22 Hexal Ag Granules with oily substance, manufacturing process and tablet
US7648981B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
EP1905435A3 (en) * 2003-03-11 2008-05-14 Euro-Celtique S.A. Titration dosing regimen for controlled release tramadol
US7413749B2 (en) * 2003-03-11 2008-08-19 Purdue Pharma L.P. Titration dosing regimen for controlled release tramadol
EP2186510B1 (en) * 2003-03-26 2013-07-10 Egalet Ltd. Matrix compositions for controlled delivery of drug substances
DE602004031096D1 (en) 2003-03-26 2011-03-03 Egalet As MORPHINE SYSTEM WITH CONTROLLED RELEASE
WO2004089375A1 (en) 2003-03-31 2004-10-21 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of dopamine agonist
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
WO2004093819A2 (en) 2003-04-21 2004-11-04 Euro-Celtique, S.A. Tamper resistant dosage form comprising co-extruded, adverse agent particles and process of making same
JP5670609B2 (en) * 2003-09-26 2015-02-18 アルザ・コーポレーシヨン OROS push-stick for controlled delivery of active ingredients
CA2540059C (en) * 2003-09-26 2013-08-06 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
JP5563731B2 (en) * 2003-09-26 2014-07-30 アルザ・コーポレーシヨン Controlled release formulation of opioid and non-opioid analgesics
CA2540308C (en) 2003-09-26 2013-08-06 Alza Corporation Drug coating providing high drug loading and methods for providing the same
CA2541371C (en) * 2003-10-03 2014-12-16 Atul M. Mehta Extended release formulations of opioids and method of use thereof
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
ES2321012T3 (en) 2004-03-30 2009-06-01 Euro-Celtique S.A. DOSAGE FORM RESISTANT TO INDEBITED HANDLING, INCLUDING AN ADSORBENT AND AN ADVERSE AGENT.
EP1584335A3 (en) * 2004-04-05 2006-02-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising a carbinol composition and an opioid
US20050226929A1 (en) * 2004-04-12 2005-10-13 Jianbo Xie Controlled release opioid analgesic formulation
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
KR20070044805A (en) * 2004-04-15 2007-04-30 키아스마, 인코포레이티드 Compositions capable of facilitating penetration across a biological barrier
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
CA2916869A1 (en) 2004-06-12 2005-12-29 Jane C. Hirsh Abuse-deterrent drug formulations
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
WO2006013431A1 (en) * 2004-07-29 2006-02-09 Pfizer Limited Stable controlled-release pharmaceutical formulation of eletriptan
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
CA2578540A1 (en) * 2004-09-01 2006-03-16 Euro-Celtique S.A. Opioid dosage forms having dose proportional steady state cave and auc and less than dose proportional single dose cmax
SI2415484T1 (en) 2004-09-17 2014-10-30 Durect Corporation Sustained local anesthetic composition containing SAIB
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20060127421A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment using D-threo methylphenidate
TWI432196B (en) * 2005-01-18 2014-04-01 Euro Celtique Sa Method of treating visceral pain
EP2319499A1 (en) * 2005-01-28 2011-05-11 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
CN101188999B (en) * 2005-06-03 2012-07-18 尹格莱特股份有限公司 A pharmaceutical delivery system for delivering active component dispersed in dispersion medium
JP2009501785A (en) 2005-07-20 2009-01-22 パナセア バイオテック リミテッド Novel controlled release pharmaceutical formulation cyclooxygenase enzyme inhibitor
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
NZ592836A (en) 2005-07-27 2013-01-25 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
JP2009506059A (en) 2005-08-24 2009-02-12 ペンウエスト ファーマシューティカルズ カンパニー Nalbuphine sustained release formulation
US8394812B2 (en) 2005-08-24 2013-03-12 Penwest Pharmaceuticals Co. Sustained release formulations of nalbuphine
BRPI0615860B8 (en) 2005-09-09 2021-05-25 Labopharm Barbados Ltd solid monolithic extended release pharmaceutical composition
US20070160960A1 (en) * 2005-10-21 2007-07-12 Laser Shot, Inc. System and method for calculating a projectile impact coordinates
US8022054B2 (en) 2005-11-28 2011-09-20 Marinus Pharmaceuticals Liquid ganaxolone formulations and methods for the making and use thereof
FR2894143B1 (en) * 2005-12-01 2008-05-02 Pierre Fabre Medicament Sa PROLONGED RELEASE COMPOSITION OF THE ACTIVE INGREDIENTS, PROCESS FOR PREPARING THE SAME AND USE THEREOF
EP1810678A1 (en) * 2006-01-19 2007-07-25 Holger Lars Hermann Use of morphine and naloxone for drug substitution
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
US8784886B2 (en) 2006-03-09 2014-07-22 GlaxoSmithKline, LLC Coating capsules with active pharmaceutical ingredients
EP2081550B2 (en) 2006-03-09 2021-05-26 Reliant Pharmaceuticals, Inc. Coating capsules with active pharmaceutical ingredients
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
PL2719378T3 (en) 2006-06-19 2017-02-28 Alpharma Pharmaceuticals Llc Pharmaceutical compositions
ATE462416T1 (en) * 2006-08-04 2010-04-15 Ethypharm Sa MULTI-LAYER OROUGH DISSOLVING TABLET
SA07280459B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
US9744137B2 (en) 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
CA2665841C (en) 2006-10-09 2016-04-05 Charleston Laboratories, Inc. Pharmaceutical compositions
EP2484347A1 (en) 2006-11-03 2012-08-08 Durect Corporation Transdermal delivery systems comprising bupivacaine
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
ES2312308T3 (en) 2006-11-17 2013-03-26 Supernus Pharmaceuticals, Inc. Topiramate sustained release formulations
JP2010510988A (en) * 2006-11-28 2010-04-08 マリナス ファーマシューティカルズ Nanoparticle formulation, method for producing the same and use thereof
ES2422655T3 (en) * 2006-12-04 2013-09-12 Supernus Pharmaceuticals Inc Enhanced immediate release formulations of topiramate
US8202542B1 (en) 2007-05-31 2012-06-19 Tris Pharma Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
US20080318993A1 (en) * 2007-06-21 2008-12-25 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment
US20080318994A1 (en) * 2007-06-21 2008-12-25 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment
JP5965583B2 (en) * 2007-08-13 2016-08-10 インスピリオン デリバリー テクノロジーズ エルエルシー Abuse resistant pharmaceutical composition, method of use and preparation
JP5453280B2 (en) * 2007-10-16 2014-03-26 ラボファーム インコーポレイテッド Bilayer composition for sustained release of acetaminophen and tramadol
EP2067471B1 (en) 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
BRPI0821732A2 (en) 2007-12-17 2015-06-16 Labopharm Inc Controlled release formulations, solid dosage form, and use of controlled release formulation
CA2905541C (en) 2008-01-09 2020-02-11 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
EP2262484B1 (en) 2008-03-11 2013-01-23 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
CN102176900B (en) 2008-09-17 2017-09-26 克艾思马有限公司 Pharmaceutical composition and related medication
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102316857A (en) 2008-12-16 2012-01-11 莱博法姆公司 Prevent the controlled release formulation misapplied
US8362029B2 (en) 2008-12-31 2013-01-29 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
HUE042105T2 (en) 2009-03-10 2019-06-28 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
EP2445487A2 (en) 2009-06-24 2012-05-02 Egalet Ltd. Controlled release formulations
EP3311667A1 (en) 2009-07-08 2018-04-25 Charleston Laboratories, Inc. Pharmaceutical compositions
PL399450A1 (en) * 2009-08-31 2013-01-21 Depomed, Inc Remaining in the stomach pharmaceutical compositions for the immediate and prolonged release of acetaminophen
AU2009352681B2 (en) 2009-09-17 2014-11-20 Upsher-Smith Laboratories, Llc A sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti -inflammatory drug
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
EP2568977A1 (en) 2010-05-11 2013-03-20 Cima Labs Inc. Alcohol-resistant metoprolol-containing extended- release oral dosage forms
JP5819680B2 (en) * 2010-09-03 2015-11-24 帝人ファーマ株式会社 Small sustained release formulation of ambroxol hydrochloride
EP2826467B1 (en) 2010-12-22 2017-08-02 Purdue Pharma L.P. Encased tamper resistant controlled release dosage forms
AU2011346758C1 (en) 2010-12-23 2015-09-03 Purdue Pharma L.P. Tamper resistant solid oral dosage forms
US8658631B1 (en) 2011-05-17 2014-02-25 Mallinckrodt Llc Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
ES2716570T3 (en) 2012-04-17 2019-06-13 Purdue Pharma Lp Systems and methods for treating or preventing an adverse pharmacodynamic response induced by opioids
CN104684548A (en) 2012-07-06 2015-06-03 埃格勒特有限责任公司 Abuse deterrent pharmaceutical compositions for controlled release
US9730885B2 (en) 2012-07-12 2017-08-15 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
US10322120B2 (en) 2012-07-31 2019-06-18 Persion Pharmaceuticals Llc Treating pain in patients with hepatic impairment
EP2953618B1 (en) 2013-02-05 2020-11-11 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CN105120659A (en) 2013-03-15 2015-12-02 度瑞公司 Compositions with a rheological modifier to reduce dissolution variability
EP2799009A1 (en) * 2013-04-29 2014-11-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-invasive method for prediction of opioid-analgesia and opioid-blood-concentrations
ES2718211T3 (en) 2013-05-24 2019-06-28 Rhodes Tech Opioid ketal compounds and uses thereof
KR20180037074A (en) 2013-07-23 2018-04-10 유로-셀티큐 에스.에이. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
US9849124B2 (en) 2014-10-17 2017-12-26 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
CA2936748C (en) 2014-10-31 2017-08-08 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
AU2016215350B2 (en) 2015-02-03 2021-11-25 Amryt Endo, Inc. Method of treating diseases
US9145420B1 (en) 2015-03-27 2015-09-29 Johnson Matthey Public Limited Company Crystalline forms of morphine sulfate
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
DE102016014603A1 (en) 2016-06-30 2018-01-04 Thomas Herkenroth Synthetic ayahuasca
MX2019001669A (en) 2016-08-11 2019-09-27 Ovid Therapeutics Inc Methods and compositions for treatment of epileptic disorders.
CN106266068A (en) * 2016-09-18 2017-01-04 遵义师范学院 A kind of rapid release delays control release type to sitting leaf pellet capsule and preparation method thereof
JP7284764B2 (en) 2018-02-23 2023-05-31 ロデス テクノロジーズ Novel opioid compounds and uses thereof
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
WO2020118142A1 (en) 2018-12-07 2020-06-11 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of pospartum depression
EP4009982A4 (en) 2019-08-05 2023-08-09 Marinus Pharmaceuticals, Inc. Ganaxolone for use in treatment of status epilepticus
KR20220140711A (en) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Citations (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) * 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3393197A (en) * 1966-01-19 1968-07-16 Endo Lab Nu-substituted-14-hydroxydihydronormorphines
US3684584A (en) * 1971-03-15 1972-08-15 Driver Co Wilbur B Thermocouple extension wire
US3870790A (en) * 1970-01-22 1975-03-11 Forest Laboratories Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose
US4088864A (en) * 1974-11-18 1978-05-09 Alza Corporation Process for forming outlet passageways in pills using a laser
US4162753A (en) * 1978-07-13 1979-07-31 Brown William R Necktie hanger
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
US4385078A (en) * 1978-09-04 1983-05-24 Shin-Etsu Chemical Co., Ltd. Method for providing enteric coating on solid dosage forms and aqueous compositions therefor
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4466646A (en) * 1983-02-25 1984-08-21 General Motors Corporation Energy absorbing bumper assembly for vehicles
US4520172A (en) * 1982-03-11 1985-05-28 Rohm Gmbh Method for coating medicaments
US4548990A (en) * 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
US4600645A (en) * 1985-01-31 1986-07-15 Warner-Lambert Company Process for treating dosage forms
US4728513A (en) * 1985-07-31 1988-03-01 Zyma Sa Granular delayed-release form of pharmaceutically active substances
US4797410A (en) * 1985-05-13 1989-01-10 Miles Inc. Suppression of withdrawal symptoms in opioid-induced tolerance or dependence
US4800084A (en) * 1984-02-01 1989-01-24 Horst Zerbe Pharmaceutical product in the form of a pellet with continuous, delayed medicament substance emission
US4806337A (en) * 1984-07-23 1989-02-21 Zetachron, Inc. Erodible matrix for sustained release bioactive composition
US4828836A (en) * 1986-06-05 1989-05-09 Euroceltique S.A. Controlled release pharmaceutical composition
US4834985A (en) * 1986-06-05 1989-05-30 Euroceltique S.A. Controlled release pharmaceutical composition
US4834984A (en) * 1986-06-10 1989-05-30 Euroceltique S.A. Controlled release dihydrocodeine composition
US4844907A (en) * 1985-08-28 1989-07-04 Euroceltique, S.A. Pharmaceutical composition comprising analgesic and anti-inflammatory agent
US4844909A (en) * 1986-10-31 1989-07-04 Euroceltique, S.A. Controlled release hydromorphone composition
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4894234A (en) * 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for antiarrhythmics
US4935246A (en) * 1987-07-01 1990-06-19 Hoechst Aktiengesellschaft Process for the coating of granules
US4940587A (en) * 1985-06-11 1990-07-10 Euroceltique, S.A. Oral pharmaceutical composition through mucosa
US4983730A (en) * 1988-09-02 1991-01-08 Hoechst Celanese Corporation Water soluble cellulose acetate composition having improved processability and tensile properties
US4994276A (en) * 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5023089A (en) * 1988-07-18 1991-06-11 Shionogi & Co., Ltd. Sustained-release preparations and the process thereof
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5030400A (en) * 1989-07-03 1991-07-09 A/S Niro Atomizer Process and an apparatus for agglomeration of a powdery material
US5047248A (en) * 1986-03-07 1991-09-10 Eurand Italia S.P.A. Formulation for preparing sustained release drugs for oral administration
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5126145A (en) * 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5128143A (en) * 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US5132142A (en) * 1991-03-19 1992-07-21 Glatt Gmbh Apparatus and method for producing pellets by layering power onto particles
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5135757A (en) * 1988-09-19 1992-08-04 Edward Mendell Co., Inc. Compressible sustained release solid dosage forms
US5178868A (en) * 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
US5196203A (en) * 1989-01-06 1993-03-23 F. H. Faulding & Co. Limited Theophylline dosage form
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5226331A (en) * 1991-10-03 1993-07-13 General Electric Company Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5292461A (en) * 1990-08-24 1994-03-08 Juch Rolf Dieter Process for the production of pellets
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
US5330766A (en) * 1989-01-06 1994-07-19 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5358269A (en) * 1993-08-30 1994-10-25 Jakeman Walter L Trailer hitch
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5415871A (en) * 1986-01-18 1995-05-16 The Boots Company Plc Therapeutic agents
US5431922A (en) * 1991-03-05 1995-07-11 Bristol-Myers Squibb Company Method for administration of buspirone
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5456923A (en) * 1991-04-16 1995-10-10 Nippon Shinyaku Company, Limited Method of manufacturing solid dispersion
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
US5502058A (en) * 1993-03-05 1996-03-26 Virginia Commonwealth University Method for the treatment of pain
US5508042A (en) * 1991-11-27 1996-04-16 Euro-Celtigue, S.A. Controlled release oxycodone compositions
US5520931A (en) * 1992-07-29 1996-05-28 Gacell Laboratories Ab Controlled release morphine preparation
US5601842A (en) * 1993-09-03 1997-02-11 Gruenenthal Gmbh Sustained release drug formulation containing a tramadol salt
US5614218A (en) * 1993-03-30 1997-03-25 Pharmacia & Upjohn Aktiebolag Controlled release preparation
US5629011A (en) * 1992-02-05 1997-05-13 Danbiosyst Uk Limited Composition for nasal administration
US5639476A (en) * 1992-01-27 1997-06-17 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5662933A (en) * 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
US5672360A (en) * 1993-11-23 1997-09-30 Purdue Pharma, L.P. Method of treating pain by administering 24 hour oral opioid formulations
US5709883A (en) * 1995-09-29 1998-01-20 L.A.M. Pharmaceuticals, Llc Long acting narcotic analgesics and antagonists
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US5914131A (en) * 1994-07-07 1999-06-22 Alza Corporation Hydromorphone therapy
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US5958452A (en) * 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US6085954A (en) * 1998-07-15 2000-07-11 Graber Products, Inc. Pivoting extensible rear hitch attachment for equipment carrier
US6103261A (en) * 1993-07-01 2000-08-15 Purdue Pharma Lp Opioid formulations having extended controlled release
US6221393B1 (en) * 1995-01-27 2001-04-24 Rhodia Chimie Pharmaceutical compositions in the form of sustained-release tablets based on high molecular weight polysaccharide granules
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6294195B1 (en) * 1991-12-24 2001-09-25 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US6340475B2 (en) * 1997-06-06 2002-01-22 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US6413494B1 (en) * 1998-07-23 2002-07-02 Samyang Corporation Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides
US6432438B1 (en) * 1997-10-29 2002-08-13 Atul J. Shukla Biodegradable vehicle and filler
US20030091635A1 (en) * 2001-09-26 2003-05-15 Baichwal Anand R. Opioid formulations having reduced potential for abuse
US20030130297A1 (en) * 2001-07-06 2003-07-10 Endo Pharmaceuticals, Inc. Oral administration of 6-hydroxy-oxymorphone for use as an analgesic
US20030129230A1 (en) * 2001-07-06 2003-07-10 Penwest Pharmaceuticals Company Sustained release formulations of oxymorphone
US6736434B2 (en) * 2000-03-22 2004-05-18 Meridian Automotive Systems, Inc. Vehicle and bumper assembly therefor having an integral fascia and energy absorber, and method for making the same

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634584A (en) * 1969-02-13 1972-01-11 American Home Prod Sustained action dosage form
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3916889A (en) * 1973-09-28 1975-11-04 Sandoz Ag Patient ventilator apparatus
US4034758A (en) * 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4063064A (en) * 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
DE3024416C2 (en) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Process for the production of medicaments with sustained release of active substances
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4557925A (en) * 1982-07-08 1985-12-10 Ab Ferrosan Membrane-coated sustained-release tablets and method
ZA836627B (en) * 1982-10-08 1984-05-30 Verex Lab Constant release rate solid oral dosage formulation of pharmaceutical compounds having a high degree of water solubility
EP0147780A3 (en) * 1984-01-03 1987-03-11 Merck & Co. Inc. Drug delivery device
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
NL8500724A (en) * 1985-03-13 1986-10-01 Univ Groningen DEVICES FOR REGULAR RELEASE OF ACTIVE SUBSTANCES AND METHOD OF MANUFACTURE THEREOF
GB2186485B (en) * 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
US4756911A (en) * 1986-04-16 1988-07-12 E. R. Squibb & Sons, Inc. Controlled release formulation
US4970075A (en) * 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
JP2643222B2 (en) 1988-02-03 1997-08-20 エーザイ株式会社 Multi-layer granules
CA2002492A1 (en) * 1988-11-11 1990-05-11 Sandra T. A. Malkowska Pharmaceutical ion exchange resin composition
CA2007181C (en) * 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5326572A (en) * 1989-03-23 1994-07-05 Fmc Corporation Freeze-dried polymer dispersions and the use thereof in preparing sustained-release pharmaceutical compositions
EP0415693A1 (en) * 1989-08-28 1991-03-06 Arizona Technology Development Corporation Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence
US5169645A (en) * 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
US5198203A (en) * 1990-01-25 1993-03-30 Mobil Oil Corp. Synthetic mesoporous crystalline material
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
SE9003296L (en) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab PROCEDURE SHOULD FORMULATE MEDICINAL PRODUCTS
EP0534628B1 (en) * 1991-09-06 1996-11-20 Mcneilab, Inc. Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use
DK0566709T5 (en) * 1991-09-06 2009-05-18 Ortho Mcneil Janssen Pharm Composition containing a tramadol material and acetaminophen and use thereof
US5223541A (en) * 1991-09-13 1993-06-29 Mcneilab, Inc. Tramadol n-oxide material, enantiomers and compositions thereof, and their use
GB9121204D0 (en) * 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5407686A (en) * 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5273760A (en) * 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5472712A (en) * 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5681585A (en) * 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5167964A (en) * 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
SE9200858L (en) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Method for producing delayed release pellets
CA2147283C (en) * 1992-10-16 2007-01-16 Kouichi Nakamichi Method of manufacturing wax matrices
EP0621032B1 (en) * 1993-04-23 2000-08-09 Novartis AG Controlled release drug delivery device
IL119660A (en) * 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
DE4315525B4 (en) 1993-05-10 2010-04-15 Euro-Celtique S.A. Pharmaceutical composition
IL109944A (en) * 1993-07-01 1998-12-06 Euro Celtique Sa Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
EP1442745A1 (en) * 1993-10-07 2004-08-04 Euro-Celtique Orally administrable opioid formulations having extended duration of effect
KR100354702B1 (en) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 Manufacturing method and sustained release composition of pharmaceutical composition
US5529787A (en) * 1994-07-07 1996-06-25 Alza Corporation Hydromorphone therapy

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738303A (en) * 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3393197A (en) * 1966-01-19 1968-07-16 Endo Lab Nu-substituted-14-hydroxydihydronormorphines
US3870790A (en) * 1970-01-22 1975-03-11 Forest Laboratories Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose
US3684584A (en) * 1971-03-15 1972-08-15 Driver Co Wilbur B Thermocouple extension wire
US4088864A (en) * 1974-11-18 1978-05-09 Alza Corporation Process for forming outlet passageways in pills using a laser
US4162753A (en) * 1978-07-13 1979-07-31 Brown William R Necktie hanger
US4385078A (en) * 1978-09-04 1983-05-24 Shin-Etsu Chemical Co., Ltd. Method for providing enteric coating on solid dosage forms and aqueous compositions therefor
US4464378A (en) * 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
US4520172A (en) * 1982-03-11 1985-05-28 Rohm Gmbh Method for coating medicaments
US4389393B1 (en) * 1982-03-26 1985-10-22
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4466646A (en) * 1983-02-25 1984-08-21 General Motors Corporation Energy absorbing bumper assembly for vehicles
US4548990A (en) * 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4800084A (en) * 1984-02-01 1989-01-24 Horst Zerbe Pharmaceutical product in the form of a pellet with continuous, delayed medicament substance emission
US4806337A (en) * 1984-07-23 1989-02-21 Zetachron, Inc. Erodible matrix for sustained release bioactive composition
US4894234A (en) * 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for antiarrhythmics
US4600645A (en) * 1985-01-31 1986-07-15 Warner-Lambert Company Process for treating dosage forms
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
US4797410A (en) * 1985-05-13 1989-01-10 Miles Inc. Suppression of withdrawal symptoms in opioid-induced tolerance or dependence
US4940587A (en) * 1985-06-11 1990-07-10 Euroceltique, S.A. Oral pharmaceutical composition through mucosa
US4728513A (en) * 1985-07-31 1988-03-01 Zyma Sa Granular delayed-release form of pharmaceutically active substances
US4844907A (en) * 1985-08-28 1989-07-04 Euroceltique, S.A. Pharmaceutical composition comprising analgesic and anti-inflammatory agent
US5415871A (en) * 1986-01-18 1995-05-16 The Boots Company Plc Therapeutic agents
US5047248A (en) * 1986-03-07 1991-09-10 Eurand Italia S.P.A. Formulation for preparing sustained release drugs for oral administration
US4828836A (en) * 1986-06-05 1989-05-09 Euroceltique S.A. Controlled release pharmaceutical composition
US4834985A (en) * 1986-06-05 1989-05-30 Euroceltique S.A. Controlled release pharmaceutical composition
US4834984A (en) * 1986-06-10 1989-05-30 Euroceltique S.A. Controlled release dihydrocodeine composition
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4990341A (en) * 1986-10-31 1991-02-05 Euroceltique, S.A. Controlled release hydromorphone composition
US4844909A (en) * 1986-10-31 1989-07-04 Euroceltique, S.A. Controlled release hydromorphone composition
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4935246A (en) * 1987-07-01 1990-06-19 Hoechst Aktiengesellschaft Process for the coating of granules
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5023089A (en) * 1988-07-18 1991-06-11 Shionogi & Co., Ltd. Sustained-release preparations and the process thereof
US4983730A (en) * 1988-09-02 1991-01-08 Hoechst Celanese Corporation Water soluble cellulose acetate composition having improved processability and tensile properties
US5128143A (en) * 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US4994276A (en) * 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
US5135757A (en) * 1988-09-19 1992-08-04 Edward Mendell Co., Inc. Compressible sustained release solid dosage forms
US5178868A (en) * 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
US5378474A (en) * 1989-01-06 1995-01-03 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5330766A (en) * 1989-01-06 1994-07-19 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5196203A (en) * 1989-01-06 1993-03-23 F. H. Faulding & Co. Limited Theophylline dosage form
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5126145A (en) * 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5122384A (en) * 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5030400A (en) * 1989-07-03 1991-07-09 A/S Niro Atomizer Process and an apparatus for agglomeration of a powdery material
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5292461A (en) * 1990-08-24 1994-03-08 Juch Rolf Dieter Process for the production of pellets
US5431922A (en) * 1991-03-05 1995-07-11 Bristol-Myers Squibb Company Method for administration of buspirone
US5132142A (en) * 1991-03-19 1992-07-21 Glatt Gmbh Apparatus and method for producing pellets by layering power onto particles
US5456923A (en) * 1991-04-16 1995-10-10 Nippon Shinyaku Company, Limited Method of manufacturing solid dispersion
US5226331A (en) * 1991-10-03 1993-07-13 General Electric Company Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream
US5549912A (en) * 1991-11-27 1996-08-27 Euro-Celtique, S.A. Controlled release oxycodone compositions
US5508042A (en) * 1991-11-27 1996-04-16 Euro-Celtigue, S.A. Controlled release oxycodone compositions
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US6294195B1 (en) * 1991-12-24 2001-09-25 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US20020081333A1 (en) * 1991-12-24 2002-06-27 Benjamin Oshlack Orally administrable opioid formulations having extended duration of effect
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5639476A (en) * 1992-01-27 1997-06-17 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5629011A (en) * 1992-02-05 1997-05-13 Danbiosyst Uk Limited Composition for nasal administration
US5520931A (en) * 1992-07-29 1996-05-28 Gacell Laboratories Ab Controlled release morphine preparation
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
US5502058A (en) * 1993-03-05 1996-03-26 Virginia Commonwealth University Method for the treatment of pain
US5614218A (en) * 1993-03-30 1997-03-25 Pharmacia & Upjohn Aktiebolag Controlled release preparation
US6103261A (en) * 1993-07-01 2000-08-15 Purdue Pharma Lp Opioid formulations having extended controlled release
US5358269A (en) * 1993-08-30 1994-10-25 Jakeman Walter L Trailer hitch
US5601842A (en) * 1993-09-03 1997-02-11 Gruenenthal Gmbh Sustained release drug formulation containing a tramadol salt
US5512297A (en) * 1993-09-09 1996-04-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5554387A (en) * 1993-09-09 1996-09-10 Edward Mendell Co., Ltd. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5662933A (en) * 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
US5672360A (en) * 1993-11-23 1997-09-30 Purdue Pharma, L.P. Method of treating pain by administering 24 hour oral opioid formulations
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
US5914131A (en) * 1994-07-07 1999-06-22 Alza Corporation Hydromorphone therapy
US6261599B1 (en) * 1994-11-04 2001-07-17 Euro-Celtique, S.A. Melt-extruded orally administrable opioid formulations
US5958452A (en) * 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6221393B1 (en) * 1995-01-27 2001-04-24 Rhodia Chimie Pharmaceutical compositions in the form of sustained-release tablets based on high molecular weight polysaccharide granules
US5709883A (en) * 1995-09-29 1998-01-20 L.A.M. Pharmaceuticals, Llc Long acting narcotic analgesics and antagonists
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US6340475B2 (en) * 1997-06-06 2002-01-22 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US6432438B1 (en) * 1997-10-29 2002-08-13 Atul J. Shukla Biodegradable vehicle and filler
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6085954A (en) * 1998-07-15 2000-07-11 Graber Products, Inc. Pivoting extensible rear hitch attachment for equipment carrier
US6413494B1 (en) * 1998-07-23 2002-07-02 Samyang Corporation Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides
US6736434B2 (en) * 2000-03-22 2004-05-18 Meridian Automotive Systems, Inc. Vehicle and bumper assembly therefor having an integral fascia and energy absorber, and method for making the same
US20030130297A1 (en) * 2001-07-06 2003-07-10 Endo Pharmaceuticals, Inc. Oral administration of 6-hydroxy-oxymorphone for use as an analgesic
US20030129230A1 (en) * 2001-07-06 2003-07-10 Penwest Pharmaceuticals Company Sustained release formulations of oxymorphone
US20030129234A1 (en) * 2001-07-06 2003-07-10 Penwest Pharmaceuticals Company Methods of making sustained release formulations of oxymorphone
US20030157167A1 (en) * 2001-07-06 2003-08-21 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
US20030091635A1 (en) * 2001-09-26 2003-05-15 Baichwal Anand R. Opioid formulations having reduced potential for abuse

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9861629B1 (en) 2015-10-07 2018-01-09 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US9943513B1 (en) 2015-10-07 2018-04-17 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US10478429B2 (en) 2015-10-07 2019-11-19 Patheon Softgels, Inc. Abuse deterrent dosage forms
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions

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