ES2095266T3 - Derivados de benzimidazol, su produccion y uso. - Google Patents
Derivados de benzimidazol, su produccion y uso.Info
- Publication number
- ES2095266T3 ES2095266T3 ES91106330T ES91106330T ES2095266T3 ES 2095266 T3 ES2095266 T3 ES 2095266T3 ES 91106330 T ES91106330 T ES 91106330T ES 91106330 T ES91106330 T ES 91106330T ES 2095266 T3 ES2095266 T3 ES 2095266T3
- Authority
- ES
- Spain
- Prior art keywords
- benzimidazole
- anion
- substd
- opt
- tetrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
DERIVADOS DE BENZIMIDAZOLA DE LA FORMULA (I): DONDE EL ANILLO A ES UN ANILLO BENCENO QUE PUEDE OPCIONALMENTE CONTENER SUSTITUCION EN ADICION AL GRUPO R''; R ELEVADO 1 ES HIDROGENO O UN RESIDUO DE HIDROCARBONO OPCIONALMENTE SUSTITUIDO; R (AL CUADRADO) ES UN GRUPO CAPAZ DE FORMAR UN ANION O UN GRUPO CONVERTIBLE ALLI DENTRO; X ES UNA UNION DIRECTA O ESPACIADOR TENIENDO UNA LONGITUD ATOMICA DE DOS O MENOS ENTRE EL GRUPO FENILENO Y EL GRUPO FENILO; R'' ES CARBOXILO, UNO DE SUS ESTERES, UNA DE SUS AMIDAS O UN GRUPO CAPAZ DE FORMAR UN ANION O CONVERTIBLE EN UN ANION; Y ES -O-, -S(O) SUB MHIDROGENO O UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO; Y N ES UN ENTERO DE 1 O 2; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, TIENEN UNA POTENTE ACTIVIDAD ANTAGONISTA DE ANGIOTENSINA II Y ACTIVIDAD ANTIHIPERSENSITIVA, SIENDO UTIL DE ESE MODO COMO AGENTES TERAPEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CIRCULATORIO COMO ENFERMEDADES DE HIPERTENSION, ENFERMEDADES DEL CORAZON (POR EJ., HIPERCARDIA, FALLO CARDIACO, INFARTO CARDIACO ETC.), ATAQUES, APOPLEJIA CEREBRAL, NEFRITIS, ETC.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11314890 | 1990-04-27 | ||
JP14194290 | 1990-05-30 | ||
JP20866290 | 1990-08-06 | ||
JP26457990 | 1990-10-01 | ||
JP41367990 | 1990-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095266T3 true ES2095266T3 (es) | 1997-02-16 |
Family
ID=27526589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95118796T Expired - Lifetime ES2181742T3 (es) | 1990-04-27 | 1991-04-19 | Derivados de benzoimidazol, su produccion y uso como antagonistas de angiotensina ii. |
ES91106330T Expired - Lifetime ES2095266T3 (es) | 1990-04-27 | 1991-04-19 | Derivados de benzimidazol, su produccion y uso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95118796T Expired - Lifetime ES2181742T3 (es) | 1990-04-27 | 1991-04-19 | Derivados de benzoimidazol, su produccion y uso como antagonistas de angiotensina ii. |
Country Status (22)
Country | Link |
---|---|
US (4) | US5196444A (es) |
EP (2) | EP0459136B1 (es) |
JP (2) | JP2514282B2 (es) |
KR (1) | KR100200541B1 (es) |
CN (2) | CN1048486C (es) |
AT (2) | ATE227709T1 (es) |
CA (2) | CA2040955C (es) |
CY (1) | CY2150B1 (es) |
DE (3) | DE19875004I2 (es) |
DK (2) | DK0720982T3 (es) |
ES (2) | ES2181742T3 (es) |
FI (2) | FI108434B (es) |
GR (1) | GR3022172T3 (es) |
HK (1) | HK1000803A1 (es) |
HU (2) | HU213266B (es) |
IE (1) | IE911317A1 (es) |
LU (1) | LU90224I2 (es) |
LV (1) | LV10258B (es) |
NL (1) | NL970044I2 (es) |
NO (3) | NO300923B1 (es) |
NZ (1) | NZ237949A (es) |
PT (1) | PT97451B (es) |
Families Citing this family (226)
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US5223499A (en) * | 1989-05-30 | 1993-06-29 | Merck & Co., Inc. | 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists |
IE70593B1 (en) * | 1989-09-29 | 1996-12-11 | Eisai Co Ltd | Biphenylmethane derivative the use of it and pharmacological compositions containing same |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
GB9027208D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
GB9027198D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
SI9210098B (sl) * | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
TW274551B (es) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them |
GB9201789D0 (en) * | 1992-01-28 | 1992-03-11 | Fujisawa Pharmaceutical Co | Heterocyclic derivatives |
US5354759A (en) * | 1991-09-12 | 1994-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic compounds |
JP2682353B2 (ja) * | 1991-11-20 | 1997-11-26 | 武田薬品工業株式会社 | 経口用医薬組成物およびその製造法 |
TW284688B (es) * | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
DE4203872A1 (de) * | 1992-02-11 | 1993-08-12 | Thomae Gmbh Dr K | Imidazo(1,2-a)pyridine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JPH07507271A (ja) * | 1992-03-03 | 1995-08-10 | 藤沢薬品工業株式会社 | アンジオテンシン11拮抗剤としてのベンズイミダゾール誘導体 |
US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
US5266583A (en) * | 1992-09-01 | 1993-11-30 | Merck & Co., Inc. | Angitotensin II antagonist |
DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
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US5250554A (en) * | 1989-10-24 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives useful as angiotensin II inhibitors |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
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1991
- 1991-04-18 US US07/687,238 patent/US5196444A/en not_active Expired - Lifetime
- 1991-04-19 EP EP91106330A patent/EP0459136B1/en not_active Expired - Lifetime
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- 1991-04-19 DK DK95118796T patent/DK0720982T3/da active
- 1991-04-19 EP EP95118796A patent/EP0720982B1/en not_active Expired - Lifetime
- 1991-04-19 ES ES95118796T patent/ES2181742T3/es not_active Expired - Lifetime
- 1991-04-19 DE DE1998175004 patent/DE19875004I2/de active Active
- 1991-04-19 DE DE69133149T patent/DE69133149T2/de not_active Expired - Lifetime
- 1991-04-19 DE DE69123784T patent/DE69123784T2/de not_active Expired - Lifetime
- 1991-04-19 DK DK91106330.3T patent/DK0459136T3/da active
- 1991-04-19 AT AT95118796T patent/ATE227709T1/de not_active IP Right Cessation
- 1991-04-19 AT AT91106330T patent/ATE146779T1/de active
- 1991-04-19 ES ES91106330T patent/ES2095266T3/es not_active Expired - Lifetime
- 1991-04-22 FI FI911936A patent/FI108434B/fi active Protection Beyond IP Right Term
- 1991-04-22 CA CA002040955A patent/CA2040955C/en not_active Expired - Lifetime
- 1991-04-22 JP JP3189614A patent/JP2514282B2/ja not_active Expired - Lifetime
- 1991-04-22 CA CA002204290A patent/CA2204290C/en not_active Expired - Lifetime
- 1991-04-22 NO NO911586A patent/NO300923B1/no not_active IP Right Cessation
- 1991-04-23 HU HU911347A patent/HU213266B/hu unknown
- 1991-04-23 CN CN91102569A patent/CN1048486C/zh not_active Expired - Lifetime
- 1991-04-23 PT PT97451A patent/PT97451B/pt not_active IP Right Cessation
- 1991-04-23 KR KR1019910006525A patent/KR100200541B1/ko not_active IP Right Cessation
- 1991-04-26 NZ NZ237949A patent/NZ237949A/en unknown
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1992
- 1992-12-30 LV LVP-92-567A patent/LV10258B/xx unknown
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1993
- 1993-01-05 US US07/997,703 patent/US5328919A/en not_active Expired - Lifetime
- 1993-05-10 US US08/058,739 patent/US5401764A/en not_active Expired - Lifetime
- 1993-10-05 US US08/131,667 patent/US5705517A/en not_active Expired - Lifetime
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1995
- 1995-04-18 HU HU95P/P00105P patent/HU210871A9/hu unknown
- 1995-08-29 JP JP7220844A patent/JP2853611B2/ja not_active Expired - Lifetime
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1996
- 1996-05-23 CN CN96107765A patent/CN1058966C/zh not_active Expired - Lifetime
- 1996-12-30 GR GR960403557T patent/GR3022172T3/el unknown
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1997
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- 1997-12-13 HK HK97102420A patent/HK1000803A1/xx not_active IP Right Cessation
- 1997-12-19 NL NL970044C patent/NL970044I2/nl unknown
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1998
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