ES2010561A6 - Procedimiento para preparar una composicion farmaceutica a base de un analogo de somatostatina. - Google Patents

Procedimiento para preparar una composicion farmaceutica a base de un analogo de somatostatina.

Info

Publication number
ES2010561A6
ES2010561A6 ES8802161A ES8802161A ES2010561A6 ES 2010561 A6 ES2010561 A6 ES 2010561A6 ES 8802161 A ES8802161 A ES 8802161A ES 8802161 A ES8802161 A ES 8802161A ES 2010561 A6 ES2010561 A6 ES 2010561A6
Authority
ES
Spain
Prior art keywords
breast cancer
somatostatin analogue
treating breast
analogue composition
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802161A
Other languages
English (en)
Inventor
Thomas Cavanak
Alan Haris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878716326A external-priority patent/GB8716326D0/en
Priority claimed from GB878716324A external-priority patent/GB8716324D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2010561A6 publication Critical patent/ES2010561A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA COMPOSICION FARMACEUTICA A BASE DE UN ANALOGO DE SOMATOSTATINA. COMPRENDE MEZCLAR UN ANALOGO DE SOMATOSTATINA, EN FORMA DE BASE LIBRE O DE SAL O DE UN COMPLEJO FARMACEUTICAMENTE ACEPTABLE, CON ACIDO LACTICO. LA COMPOSICION ES DE UTILIDAD EN EL TRATAMIENTO DEL CANCER DE PECHO.
ES8802161A 1987-07-10 1988-07-08 Procedimiento para preparar una composicion farmaceutica a base de un analogo de somatostatina. Expired ES2010561A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878716326A GB8716326D0 (en) 1987-07-10 1987-07-10 Organic compounds
GB878716324A GB8716324D0 (en) 1987-07-10 1987-07-10 Organic compounds

Publications (1)

Publication Number Publication Date
ES2010561A6 true ES2010561A6 (es) 1989-11-16

Family

ID=26292476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802161A Expired ES2010561A6 (es) 1987-07-10 1988-07-08 Procedimiento para preparar una composicion farmaceutica a base de un analogo de somatostatina.

Country Status (27)

Country Link
US (2) US5753618A (es)
JP (1) JP2578477B2 (es)
AU (1) AU618270B2 (es)
BE (1) BE1001079A4 (es)
CA (1) CA1328402C (es)
CH (1) CH677449A5 (es)
CS (1) CS411591A3 (es)
CY (2) CY1631A (es)
DE (2) DE3845000C2 (es)
DK (2) DK174125B1 (es)
ES (1) ES2010561A6 (es)
FI (1) FI93308C (es)
FR (1) FR2617714B1 (es)
GB (1) GB2208200B (es)
GR (1) GR1000172B (es)
HK (1) HK16492A (es)
HU (1) HU203480B (es)
IE (1) IE61908B1 (es)
IL (1) IL87044A0 (es)
LU (1) LU87268A1 (es)
MY (2) MY109309A (es)
NL (1) NL194823C (es)
NO (1) NO179359C (es)
NZ (1) NZ225340A (es)
PT (1) PT87957B (es)
SE (2) SE503191C2 (es)
SG (1) SG3692G (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2167189A1 (es) * 1999-12-17 2002-05-01 Lipotec Sa Formulacion farmaceutica estable para la administracion intravenosa o intramuscular, de principios activos peptidicos

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
US5626945A (en) * 1993-09-28 1997-05-06 International Paper Company Repulpable, water repellant paperboard
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
AU3215597A (en) * 1996-08-30 1998-03-19 Biomeasure Incorporated Method of inhibiting fibrosis with a somatostatin agonist
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
ATE424414T1 (de) * 2001-06-08 2009-03-15 Sod Conseils Rech Applic Chimere somatostatin-dopamin-analoga
TWI287986B (en) * 2001-12-13 2007-10-11 Novartis Ag Use of Epothilones for the treatment of the carcinoid syndrome
US20030207811A1 (en) * 2002-05-03 2003-11-06 Schrier Bruce K. Method of treating retinopathy of prematurity using somatostatin analogs
EP1787658B1 (en) 2005-11-10 2012-03-14 CHEMI S.p.A. Sustained release formulations of somatostatin analogue inhibitors of growth hormone
CA2647986C (en) * 2006-03-31 2014-07-08 Erasmus University Medical Center Rotterdam Compositions for tumor growth control
WO2008039482A2 (en) * 2006-09-26 2008-04-03 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US9517240B2 (en) 2006-09-26 2016-12-13 The Regents Of The University Of California Methods and compositions for cancer prevention and treatment
US20090325863A1 (en) * 2008-06-13 2009-12-31 Kleinberg David L Somatostatin analogs and IGF-I inhibition for breast cancer prevention
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
WO2012074559A2 (en) * 2010-12-02 2012-06-07 New York University Treatment of non-proliferative cystic disease
CN103732239A (zh) * 2011-06-02 2014-04-16 加利福尼亚大学董事会 利用θ-防御素的炎性蛋白酶的阻断
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621770A5 (en) * 1976-02-23 1981-02-27 Sandoz Ag Process for the preparation of novel peptide compounds
EP0000053B1 (en) * 1977-06-08 1981-05-27 Merck & Co. Inc. Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4328214A (en) * 1979-07-04 1982-05-04 Ciba-Geigy Corporation Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
US4900730A (en) * 1981-01-14 1990-02-13 Toyo Jozo Co., Ltd. Preparation which promotes the absorption of peptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS57188526A (en) * 1981-05-14 1982-11-19 Takeda Chem Ind Ltd Peptide-containing pharmaceutical preparation
US4374060A (en) * 1981-07-15 1983-02-15 Merck & Co., Inc. Process for the preparation of cyclic hexapeptide
EP0083305B1 (de) * 1981-12-24 1985-07-10 Ciba-Geigy Ag Cyclische Octapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
HU198626B (en) * 1986-05-27 1989-11-28 Sandoz Ag Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
US5187150A (en) * 1987-10-14 1993-02-16 Debiopharm S.A. Polyester-based composition for the controlled release of polypeptide medicinal substances
AU2284588A (en) * 1988-09-26 1990-03-29 Sandoz Ltd. Improvements in or relating to organic compounds
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2167189A1 (es) * 1999-12-17 2002-05-01 Lipotec Sa Formulacion farmaceutica estable para la administracion intravenosa o intramuscular, de principios activos peptidicos

Also Published As

Publication number Publication date
NO179359B (no) 1996-06-17
DK174125B1 (da) 2002-07-01
HUT47865A (en) 1989-04-28
DK385488D0 (da) 1988-07-08
FR2617714A1 (fr) 1989-01-13
SE8802569L (sv) 1989-01-11
CS411591A3 (en) 1992-06-17
IE882091L (en) 1989-01-10
DK200100558A (da) 2001-04-04
FR2617714B1 (fr) 1991-09-20
US6066616A (en) 2000-05-23
SE9301290D0 (sv) 1993-04-20
IE61908B1 (en) 1994-11-30
NO179359C (no) 1996-09-25
FI93308B (fi) 1994-12-15
SE8802569D0 (sv) 1988-07-08
DK385488A (da) 1989-01-11
NZ225340A (en) 1991-05-28
GB2208200A (en) 1989-03-15
AU1889388A (en) 1989-01-12
GR1000172B (el) 1991-11-15
SG3692G (en) 1992-03-20
JPS6431728A (en) 1989-02-02
SE503191C2 (sv) 1996-04-15
LU87268A1 (fr) 1989-03-08
DE3822557A1 (de) 1989-01-19
CY1631A (en) 1992-07-10
JP2764041B2 (ja) 1998-06-11
CY1632A (en) 1992-07-10
AU618270B2 (en) 1991-12-19
CA1328402C (en) 1994-04-12
GR880100458A (en) 1989-04-12
FI883261A (fi) 1989-01-11
IL87044A0 (en) 1988-12-30
NO883054L (no) 1989-01-11
BE1001079A4 (fr) 1989-07-04
HU203480B (en) 1991-08-28
DE3822557C2 (de) 1998-07-02
DK174476B1 (da) 2003-04-14
NL194823C (nl) 2003-04-03
NO883054D0 (no) 1988-07-08
FI93308C (fi) 1995-03-27
NL194823B (nl) 2002-12-02
US5753618A (en) 1998-05-19
GB8816024D0 (en) 1988-08-10
PT87957B (pt) 1995-03-01
JP2578477B2 (ja) 1997-02-05
JPH0748272A (ja) 1995-02-21
SE9301290A0 (sv) 1993-04-20
HK16492A (en) 1992-03-06
NL8801734A (nl) 1989-02-01
PT87957A (pt) 1989-06-30
MY109309A (en) 1997-01-31
DE3845000C2 (de) 1998-11-19
MY103746A (en) 1993-09-30
CH677449A5 (es) 1991-05-31
FI883261A0 (fi) 1988-07-08
GB2208200B (en) 1991-11-27

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20080709